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9. Versorgung von Patienten mit kardialer Amyloidose: Konsensuspapier der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V. (DGK), AG 40 Onkologische Kardiologie, und der Deutschen Gesellschaft für Hämatologie und medizinische Onkologie e. V. (DGHO), der Deutschen Gesellschaft für Neurologie e. V. (DGN) und der Deutschen Gesellschaft für Nephrologie e. V. (DGfN)

Author

Pfister, Roman, Hagenacker, Tim, Heemann, Uwe, Hegenbart, Ute, Heidecker, Bettina, Kruck, Sebastian, Knebel, Fabian, Lehmann, Lorenz, Morbach, Caroline, Rischpler, Christoph, Schulze, P. Christian, Yilmaz, Ali, and Perings, Christian

Published
2024
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12. Innate immune memory after brain injury drives inflammatory cardiac dysfunction

Author

Simats, Alba, Zhang, Sijia, Messerer, Denise, Chong, Faye, Beşkardeş, Sude, Chivukula, Aparna Sharma, Cao, Jiayu, Besson-Girard, Simon, Montellano, Felipe A., Morbach, Caroline, Carofiglio, Olga, Ricci, Alessio, Roth, Stefan, Llovera, Gemma, Singh, Rashween, Chen, Yiming, Filser, Severin, Plesnila, Nikolaus, Braun, Christian, Spitzer, Hannah, Gokce, Ozgun, Dichgans, Martin, Heuschmann, Peter U., Hatakeyama, Kinta, Beltrán, Eduardo, Clauss, Sebastian, Bonev, Boyan, Schulz, Christian, and Liesz, Arthur

Published
2024
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14. Predictors of non-recovery from fatigue and cognitive deficits after COVID-19: a prospective, longitudinal, population-based study

Author

Hartung, Tim J., Bahmer, Thomas, Chaplinskaya-Sobol, Irina, Deckert, Jürgen, Endres, Matthias, Franzpötter, Katrin, Geritz, Johanna, Haeusler, Karl G., Hein, Grit, Heuschmann, Peter U., Hopff, Sina M., Horn, Anna, Keil, Thomas, Krawczak, Michael, Krist, Lilian, Lieb, Wolfgang, Maetzler, Corina, Montellano, Felipe A., Morbach, Caroline, Neumann, Christian, Nürnberger, Carolin, Russ, Anne-Kathrin, Schmidbauer, Lena, Schmidt, Sein, Schreiber, Stefan, Steigerwald, Flo, Störk, Stefan, Zoller, Thomas, Maetzler, Walter, and Finke, Carsten

Published
2024
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15. Deep phenotyping as a contribution to personalized depression therapy: the GEParD and DaCFail protocols

Author

Lichter, Katharina, Klüpfel, Catherina, Stonawski, Saskia, Hommers, Leif, Blickle, Manuel, Burschka, Carolin, Das, Felix, Heißler, Marlene, Hellmuth, Anna, Helmel, Jaqueline, Kranemann, Leonie, Lechner, Karin, Lehrieder, Dominik, Sauter, Amelie, Schiele, Miriam A., Vijayakumar, Vithusha, von Broen, Michael, Weiß, Carolin, Morbach, Caroline, Störk, Stefan, Gelbrich, Götz, Heuschmann, Peter U., Higuchi, Takahiro, Buck, Andreas, Homola, György A., Pham, Mirko, Menke, Andreas, Domschke, Katharina, Kittel-Schneider, Sarah, and Deckert, Jürgen

Published
2023
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20. Fatigue and cognitive impairment after COVID-19: A prospective multicentre study

Author

Hartung, Tim J., Neumann, Christian, Bahmer, Thomas, Chaplinskaya-Sobol, Irina, Endres, Matthias, Geritz, Johanna, Haeusler, Karl Georg, Heuschmann, Peter U., Hildesheim, Hanna, Hinz, Andreas, Hopff, Sina, Horn, Anna, Krawczak, Michael, Krist, Lilian, Kudelka, Jennifer, Lieb, Wolfgang, Maetzler, Corina, Mehnert-Theuerkauf, Anja, Montellano, Felipe A., Morbach, Caroline, Schmidt, Sein, Schreiber, Stefan, Steigerwald, Flo, Störk, Stefan, Maetzler, Walter, and Finke, Carsten

Published
2022
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22. Severity, predictors and clinical correlates of Post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study

Author

Bahmer, Thomas, Borzikowsky, Christoph, Lieb, Wolfgang, Horn, Anna, Krist, Lilian, Fricke, Julia, Scheibenbogen, Carmen, Rabe, Klaus F., Maetzler, Walter, Maetzler, Corina, Laudien, Martin, Frank, Derk, Ballhausen, Sabrina, Hermes, Anne, Miljukov, Olga, Haeusler, Karl Georg, Mokhtari, Nour Eddine El, Witzenrath, Martin, Vehreschild, Jörg Janne, Krefting, Dagmar, Pape, Daniel, Montellano, Felipe A., Kohls, Mirjam, Morbach, Caroline, Störk, Stefan, Reese, Jens-Peter, Keil, Thomas, Heuschmann, Peter, Krawczak, Michael, and Schreiber, Stefan

Published
2022
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23. Sex-related differences in self-efficacy in patients with heart failure: a pooled cross-sectional study of the German Competence Network Heart Failure.

Author

Kerwagen, Fabian, Sahiti, Floran, Albert, Judith, Bauser, Maximilian, Morbach, Caroline, Güder, Gülmisal, Frantz, Stefan, Strömberg, Anna, Kerber, Sebastian, Gebhard, Brigitte, Friederich, Hans-Christoph, Müller-Tasch, Thomas, Peters-Klimm, Frank, Angermann, Christiane E, and Störk, Stefan

Abstract

Aims To assess the level of self-efficacy in patients with heart failure (HF), identify differences between important subgroups including sex, and identify the determinants of high self-efficacy. Methods and results This was a pooled cross-sectional analysis of 2030 patients from 4 prospective studies conducted within the German Competence Network Heart Failure. We used the self-efficacy subscale and the overall summary score (OSS) of the Kansas City Cardiomyopathy Questionnaire (KCCQ-23) to assess self-efficacy and health-related quality of life. The cut-off of 75 score points was used for the dichotomization into high (≥75) vs. low (<75) self-efficacy. Depressive symptoms were measured by the Patient Health Questionnaire (PHQ-9). A total of 1615 patients with HF provided complete self-efficacy scores: mean age 66.6 ± 12.3 years and 431 (27%) women. The mean self-efficacy score was 67.5 ± 24.9, with 907 patients (56.2%) showing high self-efficacy and 708 patients (43.8%) showing low self-efficacy. Men had higher self-efficacy scores than women (68.7 ± 24.5 vs. 64.2 ± 26.0; P = 0.001). Multivariable logistic regression identified the KCCQ-OSS [odds ratio (OR) per five-point increase 1.08, 95% confidence interval (CI) 1.04–1.12], female sex (OR 0.72, 95% CI 0.56–0.94), depressive symptoms (OR per three-point increase in PHQ-9 0.90, 95% CI 0.83–0.98), and acute HF (OR 0.46, 95% CI 0.34–0.62) as important predictors of high self-efficacy. Conclusion In patients with HF, women seemed to exhibit lower self-efficacy than men. Health-related quality of life and psychological well-being were dominant determinants of self-efficacy. Future studies should investigate the role of self-efficacy as a therapeutic target for tailored and sex-specific nursing interventions. [ABSTRACT FROM AUTHOR]

Published
2025
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29. Expert opinion paper on cardiac imaging after ischemic stroke

Author

Schnabel, Renate B., Camen, Stephan, Knebel, Fabian, Hagendorff, Andreas, Bavendiek, Udo, Böhm, Michael, Doehner, Wolfram, Endres, Matthias, Gröschel, Klaus, Goette, Andreas, Huttner, Hagen B., Jensen, Christoph, Kirchhof, Paulus, Korosoglou, Grigorios, Laufs, Ulrich, Liman, Jan, Morbach, Caroline, Nabavi, Darius Günther, Neumann-Haefelin, Tobias, Pfeilschifter, Waltraud, Poli, Sven, Rizos, Timolaos, Rolf, Andreas, Röther, Joachim, Schäbitz, Wolf Rüdiger, Steiner, Thorsten, Thomalla, Götz, Wachter, Rolf, and Haeusler, Karl Georg

Published
2021
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30. Cardiovascular status in endogenous cortisol excess: the prospective CV-CORT-EX study.

Author

Morbach, Caroline, Detomas, Mario, Sahiti, Floran, Hoffmann, Kristina, Kroiss, Matthias, Gelbrich, Götz, Frantz, Stefan, Hahner, Stefanie, Heuschmann, Peter Ulrich, Fassnacht, Martin, Störk, Stefan, and Deutschbein, Timo

Subjects
*CUSHING'S syndrome, *METABOLIC syndrome, *HYDROCORTISONE, *GLUCOCORTICOIDS, *ECHOCARDIOGRAPHY
Abstract

Objective Cushing's syndrome (CS) results in increased cardiovascular (CV) morbidity and mortality. Subtype-specific differences and possible reversibility after biochemical cure are not well investigated. Design Prospective cohort study evaluating the CV status in different forms of endogenous cortisol excess. Methods Patients with overt CS (n = 40, 47 ± 13 years, 75% women; 18 pituitary, 13 adrenal, and 9 ectopic), biochemically cured CS (n = 56, 53 ± 12 years, 79% women; 30 pituitary, 21 adrenal, and 5 ectopic), and adrenal incidentalomas with mild autonomous cortisol secretion (MACS) (n = 18, 62 ± 11 years, 56% women) underwent comprehensive biochemical, metabolic, and CV assessment. Results were compared with a representative sample of the general population of Würzburg (n = 4965, 55 ± 12 years, 52% women). Results Overt CS was associated with left ventricular (LV) remodeling along with hypertrophy and impaired longitudinal systolic/diastolic function at echocardiography. In 20 CS patients followed for a median of 8 (quartiles: 6, 11) months after biochemical remission, hypertension, and hyperglycemia were better controlled, while cardiac alterations only partially improved. Patients with previous CS (median time of biochemical remission: 95 [36, 201] months) had worse diastolic function than the general population (LV relaxation velocity e′ 0.08 [0.07, 0.10] ms−1 vs 0.10 [0.08, 0.12] ms−1, P <.001). In MACS, cardiac remodeling was even more pronounced than in individuals with metabolic syndrome. Conclusions In patients with overt CS, cured CS, and MACS, we found a sizable and significant deviation from the general population mean regarding cardiac structure and function. Even mild cortisol excess is associated with glucocorticoid-induced cardiac alterations, which appear to persist despite long-term biochemical remission. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Biomarkers to improve functional outcome prediction after ischemic stroke: Results from the SICFAIL, STRAWINSKI, and PREDICT studies.

Author

Montellano, Felipe A, Rücker, Viktoria, Ungethüm, Kathrin, Penalba, Anna, Hotter, Benjamin, Giralt, Marina, Wiedmann, Silke, Mackenrodt, Daniel, Morbach, Caroline, Frantz, Stefan, Störk, Stefan, Whiteley, William N, Kleinschnitz, Christoph, Meisel, Andreas, Montaner, Joan, Haeusler, Karl Georg, and Heuschmann, Peter U

Published
2024
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32. Long‐term cognitive and brain morphologic changes in chronic heart failure: Results of the Cognition.Matters‐HF study.

Author

Traub, Jan, Homola, György, Morbach, Caroline, Sell, Roxanne, Göpfert, Dennis, Frantz, Stefan, Pham, Mirko, Stoll, Guido, Störk, Stefan, and Frey, Anna

Subjects
MAGNETIC resonance imaging, CEREBRAL atrophy, COGNITIVE testing, TREATMENT effectiveness, CARDIAC imaging
Abstract

Aims: Cognitive impairment (CI) is a common, yet frequently unrecognized co‐morbidity in chronic heart failure (HF). We quantified trajectories of cognitive performance, brain volume, and related clinical outcome over a time course of 6 years. Methods and results: The Cognition.Matters‐HF cohort study recruited patients with stable HF of any aetiology and severity. Beyond cardiological assessment, the workup included cognitive testing and brain magnetic resonance imaging (MRI). Of 148 recruited patients, 70% exhibited CI at baseline. During the median follow‐up time of 69 months (quartiles: 68, 70), indicators of HF severity remained essentially unaltered. CI was also stable, with the exception of intensity of attention, where age‐adjusted t‐scores decreased from 42 (38, 46) to 38 (34, 44; P < 0.001). Complete sets of four serial brain MRI scans were available in 47 patients (32% of total sample). Total brain volume shrank by 0.4% per year, from 1103 (1060, 1143) cm3 to 1078 (1027, 1117) cm3, which was within limits observed in non‐diseased ageing individuals. During follow‐up, 29 study participants (20%) died, and 26 (18%) were at least once hospitalized due to worsening HF. The presence of CI was not associated with overall (P = 0.290) or hospitalization‐free (P = 0.450) survival. Conclusions: In patients with stable HF patients receiving guideline‐directed pharmacologic treatment and regular medical care, the presence of CI did not affect overall and hospitalization‐free 6‐year survival. The loss of brain parenchyma observed in patients with stable HF did not exceed that of normal ageing. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Sex-related differences in self-efficacy in patients with heart failure: a pooled cross-sectional study of the German Competence Network Heart Failure

Author

Kerwagen, Fabian, Sahiti, Floran, Albert, Judith, Bauser, Maximilian, Morbach, Caroline, Gueder, Guelmisal, Frantz, Stefan, Strömberg, Anna, Kerber, Sebastian, Gebhard, Brigitte, Friederich, Hans-Christoph, Mueller-Tasch, Thomas, Peters-Klimm, Frank, Angermann, Christiane E., Stoerk, Stefan, Kerwagen, Fabian, Sahiti, Floran, Albert, Judith, Bauser, Maximilian, Morbach, Caroline, Gueder, Guelmisal, Frantz, Stefan, Strömberg, Anna, Kerber, Sebastian, Gebhard, Brigitte, Friederich, Hans-Christoph, Mueller-Tasch, Thomas, Peters-Klimm, Frank, Angermann, Christiane E., and Stoerk, Stefan

Abstract

Aims To assess the level of self-efficacy in patients with heart failure (HF), identify differences between important subgroups including sex, and identify the determinants of high self-efficacy. Methods and results This was a pooled cross-sectional analysis of 2030 patients from 4 prospective studies conducted within the German Competence Network Heart Failure. We used the self-efficacy subscale and the overall summary score (OSS) of the Kansas City Cardiomyopathy Questionnaire (KCCQ-23) to assess self-efficacy and health-related quality of life. The cut-off of 75 score points was used for the dichotomization into high (>= 75) vs. low (<75) self-efficacy. Depressive symptoms were measured by the Patient Health Questionnaire (PHQ-9). A total of 1615 patients with HF provided complete self-efficacy scores: mean age 66.6 +/- 12.3 years and 431 (27%) women. The mean self-efficacy score was 67.5 +/- 24.9, with 907 patients (56.2%) showing high self-efficacy and 708 patients (43.8%) showing low self-efficacy. Men had higher self-efficacy scores than women (68.7 +/- 24.5 vs. 64.2 +/- 26.0; P = 0.001). Multivariable logistic regression identified the KCCQ-OSS [odds ratio (OR) per five-point increase 1.08, 95% confidence interval (CI) 1.04-1.12], female sex (OR 0.72, 95% CI 0.56-0.94), depressive symptoms (OR per three-point increase in PHQ-9 0.90, 95% CI 0.83-0.98), and acute HF (OR 0.46, 95% CI 0.34-0.62) as important predictors of high self-efficacy. Conclusion In patients with HF, women seemed to exhibit lower self-efficacy than men. Health-related quality of life and psychological well-being were dominant determinants of self-efficacy. Future studies should investigate the role of self-efficacy as a therapeutic target for tailored and sex-specific nursing interventions., Funding Agencies|Federal Ministry of Education and Research (BMBF), Berlin, Germany [01GL0304]; Competence Network Heart Failure, Wurzburg, Germany (BMBF) [01GI0205/01GI1202A]; Comprehensive Heart Failure Center Wurzburg, Wurzburg, Germany (BMBF grant) [01EO1004/01EO1504]; German Research Foundation (DFG) [413657723]; Federal Ministry of Education and Research (BMBF) [16SV8877]; Interdisciplinary Center for Clinical Research (IZKF) Wurzburg (Advanced Clinician Scientist Programme Adv CSP 3); DFG [453989101]

Published
2024
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36. Cardio-Hepatic Interaction in Cardiac Amyloidosis

Author

Ihne-Schubert, Sandra Michaela, primary, Goetze, Oliver, additional, Gerstendörfer, Felix, additional, Sahiti, Floran, additional, Schade, Ina, additional, Papagianni, Aikaterini, additional, Morbach, Caroline, additional, Frantz, Stefan, additional, Einsele, Hermann, additional, Knop, Stefan, additional, Sommer, Claudia, additional, Müllhaupt, Beat, additional, Schubert, Torben, additional, Störk, Stefan, additional, and Geier, Andreas, additional

Published
2024
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45. Versorgung von Patienten mit kardialer Amyloidose

Author

Pfister, Roman, primary, Hagenacker, Tim, additional, Heemann, Uwe, additional, Hegenbart, Ute, additional, Heidecker, Bettina, additional, Kruck, Sebastian, additional, Knebel, Fabian, additional, Lehmann, Lorenz, additional, Morbach, Caroline, additional, Rischpler, Christoph, additional, Schulze, P. Christian, additional, Yilmaz, Ali, additional, and Perings, Christian, additional

Published
2023
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46. Population data–based federated machine learning improves automated echocardiographic quantification of cardiac structure and function: the Automatisierte Vermessung der Echokardiographie project

Author

Morbach, Caroline, primary, Gelbrich, Götz, additional, Schreckenberg, Marcus, additional, Hedemann, Maike, additional, Pelin, Dora, additional, Scholz, Nina, additional, Miljukov, Olga, additional, Wagner, Achim, additional, Theisen, Fabian, additional, Hitschrich, Niklas, additional, Wiebel, Hendrik, additional, Stapf, Daniel, additional, Karch, Oliver, additional, Frantz, Stefan, additional, Heuschmann, Peter U, additional, and Störk, Stefan, additional

Published
2023
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47. Activated rate-response is associated with increased mortality risk in cardiac device carriers with acute heart failure.

Author

Huttelmaier, Moritz T., Münsterer, Sascha, Morbach, Caroline, Sahiti, Floran, Scholz, Nina, Albert, Judith, Gabel, Alexander, Angermann, Christiane, Ertl, Georg, Frantz, Stefan, Störk, Stefan, and Fischer, Thomas H.

Subjects
HEART failure, VENTRICULAR ejection fraction, HOSPITAL mortality, MORTALITY, ARTIFICIAL implants, HEART assist devices, HEART beat
Abstract

Aims: This study investigated whether an activated R-mode in patients carrying a cardiac implantable electronic device (CIED) is associated with worse prognosis during and after an episode of acutely decompensated heart failure (AHF). Methods: Six hundred and twenty-three patients participating in an ongoing prospective cohort study that phenotypes and follows patients admitted for AHF were studied. We compared CIED carriers with activated R-mode stimulation (CIED-R) to CIED carriers not in R-mode (CIED-0) and patients without CIEDs (no-CIED). The independent impact of R-mode activation on 12-month all-cause death was examined using uni- and multivariable Cox proportional hazards regression taking into account potential confounders, and hazard ratios (HR) with their 95% confidence intervals (CI) were reported. Results: Mean heart rate on admission was lower in CIED-R (n = 37, 16% women) vs. CIED-0 (n = 64, 23% women) or no-CIED (n = 511, 43% women): 70 bpm vs. 80 bpm or 82 bpm; both p<0.001. In-hospital mortality was similar across groups, but age- and sex-adjusted all-cause 12-month mortality risk was differentially affected by R-mode activation; CIED-R vs. CIED-0: HR 2.44, 95%CI 1.25–4.74; CIED-R vs. no-CIED: HR 2.61, 95%CI 1.59–4.29. These effects persisted after multivariable adjustment for potential confounders. Within CIED-R, mortality risk was similar in patients with pacemakers vs. ICDs and in subgroups with left ventricular ejection fraction (LVEF) <50% vs. ≥50%. Conclusion: In patients admitted with AHF, R-mode stimulation was associated with a significantly increased 12-month mortality risk. Our findings shed new light on "admission heart rate" as a potentially treatable target in AHF. Our data are compatible with the concept that chronotropic incompetence contributes to an adverse outcome in these patients and may not be adequately treated through accelerometer-based R-mode stimulation. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Prevalence of anti‐beta‐1 antibody 6 months after hospitalization for acute heart failure predicts adverse outcome

Author

Morbach, Caroline, primary, Beyersdorf, Niklas, additional, Moser, Nicola, additional, Pelin, Dora, additional, Afshar, Boshra, additional, Ramos, Gustavo, additional, Kerkau, Thomas, additional, Kaiser, Elisa, additional, Lamers, Janna, additional, Pätkau, Jannika, additional, Sahiti, Floran, additional, Albert, Judith, additional, Güder, Gülmisal, additional, Ertl, Georg, additional, Angermann, Christiane E., additional, Frantz, Stefan, additional, Hofmann, Ulrich, additional, Jahns, Roland, additional, Jahns, Valerie, additional, and Störk, Stefan, additional

Published
2023
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