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21 results on '"Mordmüller, B.G."'

1. Immune responses associated with protection induced by chemoattenuated PfSPZ vaccine in malaria-naive Europeans

Author

Mouwenda, Yoanne D., Jochems, S.P., Unen, V. van, Ongwe, Madeleine Eunice Betouke, Steenhuijsen Piters, Wouter A.A. de, Stam, K.A., Mordmüller, B.G., Yazdanbakhsh, Maria, Mouwenda, Yoanne D., Jochems, S.P., Unen, V. van, Ongwe, Madeleine Eunice Betouke, Steenhuijsen Piters, Wouter A.A. de, Stam, K.A., Mordmüller, B.G., and Yazdanbakhsh, Maria

Abstract

Contains fulltext : 306986.pdf (Publisher’s version ) (Open Access)

Published
2024

2. Eosinophils, basophils and myeloid-derived suppressor cells in chronic Loa loa infection and its treatment in an endemic setting

Author

Burger, Gerrit, Adamou, Rafiou, Kreuzmair, Ruth, Ndoumba, Wilfrid Ndzebe, Mbassi, Dorothea Ekoka, Mouima, Anne Marie Nkoma, Mordmüller, B.G., Zoleko-Manego, Rella, McCall, M.B.B., Burger, Gerrit, Adamou, Rafiou, Kreuzmair, Ruth, Ndoumba, Wilfrid Ndzebe, Mbassi, Dorothea Ekoka, Mouima, Anne Marie Nkoma, Mordmüller, B.G., Zoleko-Manego, Rella, and McCall, M.B.B.

Abstract

Contains fulltext : 306772pub.pdf (Publisher’s version ) (Open Access) Contains fulltext : 306772pre.pdf (Author’s version preprint ) (Open Access)

Published
2024

3. Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection

Author

Macia, Didac, Campo, Joseph J., Moncunill, Gemma, Jairoce, Chenjerai, Nhabomba, Augusto J., Mpina, Maximilian, Mordmüller, B.G., Petrone, Paula, Dobano, Carlota, Macia, Didac, Campo, Joseph J., Moncunill, Gemma, Jairoce, Chenjerai, Nhabomba, Augusto J., Mpina, Maximilian, Mordmüller, B.G., Petrone, Paula, and Dobano, Carlota

Abstract

Item does not contain fulltext

Published
2022

5. Cellular and antibody response in GMZ2-vaccinated Gabonese volunteers in a controlled human malaria infection trial

Author

Nouatin, Odilon, Ibanez, Javier, Fendel, Rolf, Ngoa, Ulysse Ateba, Lorenz, Freia-Raphaella, Dejon-Agobe, Jean Claude, Adegnika, Ayola Akim, Mordmüller, B.G., Nouatin, Odilon, Ibanez, Javier, Fendel, Rolf, Ngoa, Ulysse Ateba, Lorenz, Freia-Raphaella, Dejon-Agobe, Jean Claude, Adegnika, Ayola Akim, and Mordmüller, B.G.

Abstract

Item does not contain fulltext

Published
2022

6. A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection

Author

Mordmüller, B.G., Sulyok, Zita, Sulyok, Mihaly, Molnar, Zsofia, Lalremruata, Albert, Calle, C.L., Gmeiner, M.S., Hoffman, Stephen L., Kremsner, P.G., Mordmüller, B.G., Sulyok, Zita, Sulyok, Mihaly, Molnar, Zsofia, Lalremruata, Albert, Calle, C.L., Gmeiner, M.S., Hoffman, Stephen L., and Kremsner, P.G.

Abstract

Contains fulltext : 253290.pdf (Publisher’s version ) (Open Access)

Published
2022

7. Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy

Author

Natasha, K.C., Preston Church, L.W., Riyahi, Pouria, Chakravarty, Sumana, Seder, R.A., Epstein, Judith E., Mordmüller, B.G., Richie, T.L., Hoffman, Stephen L., Natasha, K.C., Preston Church, L.W., Riyahi, Pouria, Chakravarty, Sumana, Seder, R.A., Epstein, Judith E., Mordmüller, B.G., Richie, T.L., and Hoffman, Stephen L.

Abstract

Contains fulltext : 285292.pdf (Publisher’s version ) (Open Access)

Published
2022

8. Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa

Author

Silva, Joana C., Dwivedi, Ankit, Moser, Kara A., Sissoko, Mahamadou S., Epstein, Judith E., Healy, Sara A., Mordmüller, B.G., Richie, T.L., Hoffman, Stephen L., Silva, Joana C., Dwivedi, Ankit, Moser, Kara A., Sissoko, Mahamadou S., Epstein, Judith E., Healy, Sara A., Mordmüller, B.G., Richie, T.L., and Hoffman, Stephen L.

Abstract

Contains fulltext : 251124.pdf (Publisher’s version ) (Open Access)

Published
2022

10. Immunosuppression in Malaria: Do Plasmodium falciparum Parasites Hijack the Host?

Author

Calle, C.L., Mordmüller, B.G., and Singh, A.

Subjects
parasitic diseases, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Abstract

Contains fulltext : 244014.pdf (Publisher’s version ) (Open Access) Malaria reflects not only a state of immune activation, but also a state of general immune defect or immunosuppression, of complex etiology that can last longer than the actual episode. Inhabitants of malaria-endemic regions with lifelong exposure to the parasite show an exhausted or immune regulatory profile compared to non- or minimally exposed subjects. Several studies and experiments to identify and characterize the cause of this malaria-related immunosuppression have shown that malaria suppresses humoral and cellular responses to both homologous (Plasmodium) and heterologous antigens (e.g., vaccines). However, neither the underlying mechanisms nor the relative involvement of different types of immune cells in immunosuppression during malaria is well understood. Moreover, the implication of the parasite during the different stages of the modulation of immunity has not been addressed in detail. There is growing evidence of a role of immune regulators and cellular components in malaria that may lead to immunosuppression that needs further research. In this review, we summarize the current evidence on how malaria parasites may directly and indirectly induce immunosuppression and investigate the potential role of specific cell types, effector molecules and other immunoregulatory factors.

Published
2021

11. A call to caution when hydroxychloroquine is given to elderly patients with COVID-19

Author

Gabor, Julian J., Kreidenweiss, Andrea, Weber, Stefan, Salama, Moaaz, Sulyok, Mihaly, Sulyok, Zita, Mordmüller, B.G., Krishna, Sanjeev, and Kremsner, P.G.

Subjects
All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Abstract

Contains fulltext : 238376.pdf (Publisher’s version ) (Open Access)

Published
2021

12. Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial

Author

Sulyok, Zita, Fendel, Rolf, Eder, Bianca, Lorenz, Freia-Raphaella, Natasha, K.C., Karnahl, Matthias, Mordmüller, B.G., and Kremsner, P.G.

Subjects
All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Abstract

Contains fulltext : 238421.pdf (Publisher’s version ) (Open Access)

Published
2021

13. Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity

Author

Jong, S.E. de, Unen, V. van, Manurung, M.D., Stam, K.A., Goeman, J.J., Jochems, S.P., Höllt, T., Pezzotti, N., Mouwenda, Y.D., Ongwe, M.E. Betouke, Lorenz, Freia-Raphaella, Kruize, Y.C., Azimi, S., König, M.H., Vilanova, A., Eisemann, E., Lelieveldt, B.P., Roestenberg, M., Sim, B.K., Reinders, M.J.T., Fendel, R., Hoffman, S.L., Kremsner, P.G., Koning, F., Mordmüller, B.G., Lell, B., Yazdanbakhsh, M., Jong, S.E. de, Unen, V. van, Manurung, M.D., Stam, K.A., Goeman, J.J., Jochems, S.P., Höllt, T., Pezzotti, N., Mouwenda, Y.D., Ongwe, M.E. Betouke, Lorenz, Freia-Raphaella, Kruize, Y.C., Azimi, S., König, M.H., Vilanova, A., Eisemann, E., Lelieveldt, B.P., Roestenberg, M., Sim, B.K., Reinders, M.J.T., Fendel, R., Hoffman, S.L., Kremsner, P.G., Koning, F., Mordmüller, B.G., Lell, B., and Yazdanbakhsh, M.

Abstract

Item does not contain fulltext, Controlled human infections provide opportunities to study the interaction between the immune system and malaria parasites, which is essential for vaccine development. Here, we compared immune signatures of malaria-naive Europeans and of Africans with lifelong malaria exposure using mass cytometry, RNA sequencing and data integration, before and 5 and 11 days after venous inoculation with Plasmodium falciparum sporozoites. We observed differences in immune cell populations, antigen-specific responses and gene expression profiles between Europeans and Africans and among Africans with differing degrees of immunity. Before inoculation, an activated/differentiated state of both innate and adaptive cells, including elevated CD161(+)CD4(+) T cells and interferon-γ production, predicted Africans capable of controlling parasitemia. After inoculation, the rapidity of the transcriptional response and clusters of CD4(+) T cells, plasmacytoid dendritic cells and innate T cells were among the features distinguishing Africans capable of controlling parasitemia from susceptible individuals. These findings can guide the development of a vaccine effective in malaria-endemic regions.

Published
2021

14. Molecular surveillance and genetic divergence of rotavirus A antigenic epitopes in Gabonese children with acute gastroenteritis

Author

Manouana, G.P., Niendorf, S., Tomazatos, Alexandru, Ngwese, Mirabeau Mbong, Maloum, Moustapha Nzamba, Moure, Paul Alvyn Nguema, Mordmüller, B.G., Velavan, T.P., Adegnika, Ayola Akim, Manouana, G.P., Niendorf, S., Tomazatos, Alexandru, Ngwese, Mirabeau Mbong, Maloum, Moustapha Nzamba, Moure, Paul Alvyn Nguema, Mordmüller, B.G., Velavan, T.P., and Adegnika, Ayola Akim

Abstract

Contains fulltext : 241440.pdf (Publisher’s version ) (Open Access)

Published
2021

15. Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Author

Larsen, Mads Delbo, Lopez-Perez, Mary, Dickson, Emmanuel Kakra, Ampomah, Paulina, Tuikue Ndam, Nicaise, Nouta, Jan, Mordmüller, B.G., Hviid, Lars, Vidarsson, Gestur, Larsen, Mads Delbo, Lopez-Perez, Mary, Dickson, Emmanuel Kakra, Ampomah, Paulina, Tuikue Ndam, Nicaise, Nouta, Jan, Mordmüller, B.G., Hviid, Lars, and Vidarsson, Gestur

Abstract

Contains fulltext : 238867.pdf (Publisher’s version ) (Open Access)

Published
2021

16. Genetic Diversity of Enteric Viruses in Children under Five Years Old in Gabon

Author

Manouana, G.P., Nguema-Moure, P.A., Mbong Ngwese, M., Bock, C.T., Kremsner, P.G., Borrmann, S., Eibach, D., Mordmüller, B.G., Velavan, T.P., Niendorf, S., Adegnika, A.A., Manouana, G.P., Nguema-Moure, P.A., Mbong Ngwese, M., Bock, C.T., Kremsner, P.G., Borrmann, S., Eibach, D., Mordmüller, B.G., Velavan, T.P., Niendorf, S., and Adegnika, A.A.

Abstract

Contains fulltext : 238419.pdf (Publisher’s version ) (Open Access), Enteric viruses are the leading cause of diarrhea in children globally. Identifying viral agents and understanding their genetic diversity could help to develop effective preventive measures. This study aimed to determine the detection rate and genetic diversity of four enteric viruses in Gabonese children aged below five years. Stool samples from children <5 years with (n = 177) and without (n = 67) diarrhea were collected from April 2018 to November 2019. Norovirus, astrovirus, sapovirus, and aichivirus A were identified using PCR techniques followed by sequencing and phylogenetic analyses. At least one viral agent was identified in 23.2% and 14.9% of the symptomatic and asymptomatic participants, respectively. Norovirus (14.7%) and astrovirus (7.3%) were the most prevalent in children with diarrhea, whereas in the healthy group norovirus (9%) followed by the first reported aichivirus A in Gabon (6%) were predominant. The predominant norovirus genogroup was GII, consisting mostly of genotype GII.P31-GII.4 Sydney. Phylogenetic analysis of the 3CD region of the aichivirus A genome revealed the presence of two genotypes (A and C) in the study cohort. Astrovirus and sapovirus showed a high diversity, with five different astrovirus genotypes and four sapovirus genotypes, respectively. Our findings give new insights into the circulation and genetic diversity of enteric viruses in Gabonese children.

Published
2021

17. Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2

Author

Nouatin, Odilon, Mengue, Juliana Boex, Dejon-Agobe, Jean Claude, Fendel, Rolf, Ibanez, Javier, Ngoa, Ulysse Ateba, Mordmüller, B.G., Adegnika, Ayola Akim, Nouatin, Odilon, Mengue, Juliana Boex, Dejon-Agobe, Jean Claude, Fendel, Rolf, Ibanez, Javier, Ngoa, Ulysse Ateba, Mordmüller, B.G., and Adegnika, Ayola Akim

Abstract

Contains fulltext : 238416.pdf (Publisher’s version ) (Open Access)

Published
2021

18. Prevalence of Pathogens in Young Children Presenting to Hospital with Diarrhea from Lambaréné, Gabon

Author

Manouana, G.P., Byrne, N., Ngwese, M. Mbong, Moure, A. Nguema, Hofmann, P., Matsougou, G. Bingoulou, Mougeni, F. Lotola, Dansou, E. Nnoh, Agbanrin, M.D., Gouleu, C.S.M., Ategbo, S., Zinsou, J.F., Adegbite, B.R., Edoa, J.R., Kremsner, P.G., Mordmüller, B.G., Eibach, D., McCall, M.B.B., Abraham, A., Borrmann, S., Adegnika, A.A., Manouana, G.P., Byrne, N., Ngwese, M. Mbong, Moure, A. Nguema, Hofmann, P., Matsougou, G. Bingoulou, Mougeni, F. Lotola, Dansou, E. Nnoh, Agbanrin, M.D., Gouleu, C.S.M., Ategbo, S., Zinsou, J.F., Adegbite, B.R., Edoa, J.R., Kremsner, P.G., Mordmüller, B.G., Eibach, D., McCall, M.B.B., Abraham, A., Borrmann, S., and Adegnika, A.A.

Abstract

Contains fulltext : 238273.pdf (Publisher’s version ) (Closed access), Diarrheal disease is the second most frequent cause of mortality in children younger than 5 years worldwide, causing more than half a million deaths each year. Our knowledge of the epidemiology of potentially pathogenic agents found in children suffering from diarrhea in sub-Saharan African countries is still patchy, and thereby hinders implementation of effective preventative interventions. The lack of cheap, easy-to-use diagnostic tools leads to mostly symptomatic and empirical case management. An observational study with a total of 241 participants was conducted from February 2017 to August 2018 among children younger than 5 years with diarrhea in Lambaréné, Gabon. Clinical and demographic data were recorded, and a stool sample was collected. The samples were examined using a commercial rapid immunoassay to detect Rotavirus/adenovirus, conventional bacterial culture for Salmonella spp., and multiplex real-time PCR for Cryptosporidium spp., Giardia lamblia, Cyclospora cayetanensis, enterotoxigenic Escherichia coli (ETEC), and enteroinvasive Escherichia coli (EIEC)/Shigella. At least one infectious agent was present in 121 of 241 (50%) samples. The most frequently isolated pathogens were EIEC/Shigella and ETEC (54/179; 30.2% and 44/179; 24.6%, respectively), followed by G. lamblia (33/241; 13.7%), Cryptosporidium spp. (31/241; 12.9%), and Rotavirus (23/241; 9.5%). Coinfection with multiple pathogens was observed in 33% (40/121) of the positive cases with EIEC/Shigella, ETEC, and Cryptosporidium spp. most frequently identified. Our results provide new insight into the possible causes of diarrheal disease in the Moyen-Ogooué region of Gabon and motivate further research on possible modes of infection and targeted preventive measures.

Published
2021

19. Associations Between Helminth Infections, Plasmodium falciparum Parasite Carriage and Antibody Responses to Sexual and Asexual Stage Malarial Antigens

Author

Ateba-Ngoa, U., Jones, S, Zinsou, J.F., Honkpehedji, J., Adegnika, A.A., Agobe, J.C., Massinga-Loembe, M., Mordmüller, B.G., Bousema, T., Yazdanbakhsh, M., Ateba-Ngoa, U., Jones, S, Zinsou, J.F., Honkpehedji, J., Adegnika, A.A., Agobe, J.C., Massinga-Loembe, M., Mordmüller, B.G., Bousema, T., and Yazdanbakhsh, M.

Abstract

Contains fulltext : 171915.pdf (publisher's version ) (Open Access), Infections with helminths and Plasmodium spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering Plasmodium falciparum gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on P. falciparum gametocyte carriage and on humoral immune responses to sexual stage antigens in Gabon. Schistosoma haematobium and filarial infections as well as P. falciparum asexual forms and gametocyte carriage were determined. The antibody responses measured were to sexual (Pfs230, Pfs48/45) and asexual P. falciparum antigens (AMA1, MSP1, and GLURP). A total of 287 subjects were included. The prevalence of microscopically detectable P. falciparum asexual parasites was higher in S. haematobium-infected subjects in comparison to their uninfected counterparts (47% versus 26%, P = 0.003), but this was not different when filarial infections were considered. Plasmodium falciparum gametocyte carriage was similar between Schistosoma- or filaria-infected and uninfected subjects. We observed a significant decrease of Pfs48/45 immunoglobulin G titer in S. haematobium-infected subjects (P = 0.037), whereas no difference was seen for Pfs230 antibody titer, nor for antibodies to AMA1, MSP1, or GLURP. Our findings suggest an effect of S. haematobium on antibody responses to some P. falciparum gametocyte antigens that may have consequences for transmission-blocking immunity.

Published
2016

20. Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines.

Author

Richie, T.L., Billingsley, P.F., Sim, B.K., James, E.R., Chakravarty, S., Epstein, J.E., Lyke, K.E., Mordmüller, B.G., Alonso, P., Duffy, P.E., Doumbo, O.K., Sauerwein, R.W., Tanner, M., Abdulla, S., Kremsner, P.G., Seder, R.A., Hoffman, S.L., Richie, T.L., Billingsley, P.F., Sim, B.K., James, E.R., Chakravarty, S., Epstein, J.E., Lyke, K.E., Mordmüller, B.G., Alonso, P., Duffy, P.E., Doumbo, O.K., Sauerwein, R.W., Tanner, M., Abdulla, S., Kremsner, P.G., Seder, R.A., and Hoffman, S.L.

Abstract

Contains fulltext : 152619.pdf (publisher's version ) (Open Access)

Published
2015

21. Causes of fever in Gabon: Epidemiology and interventions

Author

Fernandes, J.F., Grobusch, M.P., Kremsner, P.G., Mordmüller, B.G., and Faculteit der Geneeskunde

Subjects
parasitic diseases
Abstract

Fever is a key sign or symptom exhibited during infectious diseases. This research project aimed to assess the causes of fever and to contribute to the development of medicines for two locally important infectious diseases: malaria and ebola virus disease. Despite the diversity of pathogens encountered, malaria is still by far the first cause of feverish illnesses leading to hospitalizations in Gabon. Integrating the burden of malaria, it was imperative to remain devoted to optimising its curative treatment. we performed a meta-analysis on the clinical development of a potential antimalarial drug, fosmidomycin, which was found safe well-tolerated, despite some hematologic adverse events that need to be monitored. Beyond the curative aspect, we studied preventive measures by vaccines by reading through the chronological history of The RTS, S vaccine clinical development by doing a systematic review covering all phases 1, 2, and 3. Efficacy phase 2 trials showed improved immune responses and protection whilst the Phase 3 trial allowed to see that RTS, S/AS01 induced a higher vaccine efficacy when administered to children aged 5–17 months. Also in the field of vaccines for the prevention of serious febrile infections; during the largest outbreak ever which occurred in West Africa, our work at CERMEL served to evaluate, in phase 1 randomized trial, the safety and immunogenicity of rVSV-ZEBOV-GP ebola in adults and children (first pediatric cohort) in Lambaréné. Our results and other findings show that this vaccine is safe and immunogenic at the dose of 2x107 PFU in adults.

Published
2021

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