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Spike proteins, 1200 amino acids, are divided into two nearly equal parts, S1 and S2. We review here phase transition theory, implemented quantitatively by thermodynamic scaling. The theory explains the evolution of Coronavirus extremely high contagiousness caused by a few mutations from CoV2003 to CoV2019 identified among hundreds in S1. The theory previously predicted the unprecedented success of spike-based vaccines. Here we analyze impressive successes by McClellan et al., 2020, in stabilizing their original S2P vaccine to Hexapro. Hexapro has expanded the two proline mutations of S2P, 2017, to six combined proline mutations in S2. Their four new mutations are the result of surveying 100 possibilities in their detailed structure-based context Our analysis, based on only sparse publicly available data, suggests new proline mutations could improve the Hexapro combination to Octapro or beyond., Comment: 8 pages

The major challenge we face today in the energy sector is to meet the growing demand for electricity with less impact on the environment. South America is an important player in the renewable energy resource. Brazil accelerated the growth of photovoltaic installed capacity in 2018. From April of 2017 to April of 2018, the capacity increased $1351.5\%$. It is expected to reach the value of $2.4\ GW$ until the end of the year. The new Chilean regulation request that 20\% of the total electricity production in 2025 must come from renewable energy sources. The aim of this paper is to establish time series behavior changes between El Ni\~no Southern Oscillation and the solar radiation resource in South America. The results can be used to validate forecasts of energy production for new solar plants. The method used to verify the behavior of the time series was the Detrended Fluctuation Analysis. Solar radiation data were collected in twenty-five cities distributed inside the Brazilian solar belt, plus six cities in Chile, covering the continent from east to west, in a region with high potential of solar photovoltaic generation. The results shows the impact of El Ni\~no Southern Oscillation on the climatic behavior of the evaluated data. It is a factor that may lead to the wrong forecast of the long term potential solar power generation for the region.

Characterization of the non-Arrhenius behavior of glass-forming liquids is a broad avenue for research toward the understanding of the formation mechanisms of noncrystalline materials. In this context, this paper explores the main properties of the viscosity of glass-forming systems, considering super-Arrhenius diffusive processes. We establish the viscous activation energy as a function of the temperature, measure the degree of fragility of the system, and characterize the fragile-to-strong transition through the standard Angell's plot. Our results show that the non-Arrhenius behavior observed in fragile liquids can be understood through the non-Markovian dynamics that characterize the diffusive processes of these systems. Moreover, the fragile-to-strong transition corresponds to a change in the spatio-temporal range of correlations during the glass transition process.

The characterization of the formation mechanisms of amorphous solids is a large avenue for research, since understanding its non-Arrhenius behavior is challenging to overcome. In this context, we present one path toward modeling the diffusive processes in supercooled liquids near glass transition through a class of non-homogeneous continuity equations, providing a consistent theoretical basis for the physical interpretation of its non-Arrhenius behavior. More precisely, we obtain the generalized drag and diffusion coefficients that allow us to model a wide range of non-Arrhenius processes. This provides a reliable measurement of the degree of fragility of the system and an estimation of the fragile-to-strong transition in glass-forming liquids, as well as a generalized Stokes-Einstein equation, leading to a better understanding of the classical and quantum effects on the dynamics of non-additive stochastic systems.