63 results on '"Morgane Evin"'
Search Results
2. Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population
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Fedoua El Louali, Floriane Soler, Virginie Fouilloux, Morgane Evin, and Caroline Ovaert
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Medicine ,Science - Abstract
Abstract Ventricular septal defects (VSD) are the most common congenital heart diseases in children. Among them, perimembranous VSD (pm-VSD) have a higher risk of complications, including aortic valve prolapse and aortic regurgitation (AR). The aim of our study was to assess echocardiographic criteria associated with AR during follow-up of pm-VSD. Forty children with restrictive pm-VSD, followed-up in our unit and who underwent a workable echocardiographic evaluation between 2015 and 2019 were included and retrospectively analyzed. The propensity score was used to match 15 patients with AR to 15 patients without AR. Median age was 2.2 year [1.4–5.7]. Median weight was 14 kg [9.9–20.3]. Aortic annulus z-score, Valsalva sinus z-score, sinotubular junction z-score, valve prolapse and commissure commitment were significantly different between the two groups (p = 0.047, p = 0.001, p = 0.010, p = 0.007, p
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- 2023
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3. Personality trait prediction by machine learning using physiological data and driving behavior
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Morgane Evin, Antonio Hidalgo-Munoz, Adolphe James Béquet, Fabien Moreau, Helène Tattegrain, Catherine Berthelon, Alexandra Fort, and Christophe Jallais
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Driver physiological data ,Personality traits ,Machine learning ,Anxiety ,Electrodermal activity ,Cybernetics ,Q300-390 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
This article explores the influence of personality on physiological data while driving in reaction to near crashes and risky situations using Machine Learning (ML). The objective is to improve the driving assistance systems in considering drivers’ characteristics. Methods:: Physiological and behavioral data were recorded in sixty-three healthy volunteers during risky urban situations and analyzed using 5 ML algorithms to discriminate the driver’s personality according to Big Five Inventory and STAI trait. Seven step process was performed including data pre-processing, Electrodermal Activity (EDA) time windows selection (one by one backward and forward approach comparison with a pseudo-wrapped), personality traits assessment, input algorithms parameters optimization, algorithm comparison and personality trait cluster prediction. ROC Area Under the Curve (AUC) was used to describe improvement. Results/discussion:: The pseudo-wrapped/all possibilities method comparison resulted in 8.3% on average for all personality traits and all algorithms (% of ROC AUC of backward and forward approach). The ROC AUC for the detection of the personality ranged between 0.968 to 0.974 with better detection of Openness, Agreeability and Neuroticism. Use of association between Neuroticism, Extraversion and Conscientiousness previously defined in the literature slightly improve personality detection (maximum ROC AUC of 0.961 to 0.993 for cluster). Results are discussed in terms of contribution to driving aids. Conclusion:: This study is one of the first to use machine learning techniques to detect personality traits using behavioral and physiological measures in a driving context. Additionally, it questions input parameters optimization approach, time windows selection, as well as clustering and association of personality trait for detection improvement.
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- 2022
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4. MRI Assessment of the Bi-Leaflet Mechanical Heart Valve: Investigating the EOA Using the Acoustic Source Term Method
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Morgane Evin, David Joannic, Aurélien Monnet, David F. Fletcher, Stuart M. Grieve, Jean-François Fontaine, and Alain Lalande
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bi-leaflet mechanical valve ,effective orifice area ,magnetic resonance imaging ,acoustic source term ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Background: This work aims at defining the Effective Orifice Area (EOA) derived from the acoustic source term (AST) method from 4D Phase-Contrast MRI data to provide a reference for the assessment of MRI valvular prostheses as part of a comprehensive cardiac exam. Methods: Three different Bileaflet Mechanical Heart Valves (BMHV) and a dysfunctional BMHV were tested in-vitro using 4D Phase-Contrast MRI and a numerical design of the experimental study was performed, including the influence of internal diameter, stroke volume, and heart rate. The EOA AST was computed based on the MRI 4D Phase-Contrast acquisition. Results: EOAAST values vary by 15 mm from the BMHV center and should be computed between 8 to 10 mm after the metallic “blurring” artefact (ranging from 18.9 to 23.4 mm from the BMHV). EOAAST values were found to be lower compared with numerical results in the appropriate plane. Detection of the BMHV dysfunction by continuity equation computed from 4D flow acquisition is limited based on EOAAST computations, while EOAc and velocities after the valves could more directly highlight a blocked leaflet. Conclusion: This multi-disciplinary study demonstrates the suitability of the EOA AST method to assess BMHV function using MRI. Translation to the clinic is feasible using an optimized 2D Phase-Contrast flow stack or a 4D Phase-Contrast minimal volume based on the recommendations provided.
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- 2022
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5. Investigating heartbeat-related in-plane motion and stress levels induced at the aortic root
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Wei Wei, Morgane Evin, Stanislas Rapacchi, Frank Kober, Monique Bernard, Alexis Jacquier, Cyril J. F. Kahn, and Michel Behr
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Aortic root motion ,Magnetic resonance imagining ,Aortic stress ,Finite element ,Fluid–structure interaction ,Medical technology ,R855-855.5 - Abstract
Abstract Background The axial motion of aortic root (AR) due to ventricular traction was previously suggested to contribute to ascending aorta (AA) dissection by increasing its longitudinal stress, but AR in-plane motion effects on stresses have never been studied. The objective is to investigate the contribution of AR in-plane motion to AA stress levels. Methods The AR in-plane motion was assessed on magnetic resonance imagining data from 25 healthy volunteers as the movement of the AA section centroid. The measured movement was prescribed to the proximal AA end of an aortic finite element model to investigate its influences on aortic stresses. The finite element model was developed from a patient-specific geometry using LS-DYNA solver and validated against the aortic distensibility. Fluid–structure interaction (FSI) approach was also used to simulate blood hydrodynamic effects on aortic dilation and stresses. Results The AR in-plane motion was 5.5 ± 1.7 mm with the components of 3.1 ± 1.5 mm along the direction of proximal descending aorta (PDA) to AA centroid and 3.0 ± 1.3 mm perpendicularly under the PDA reference system. The AR axial motion elevated the longitudinal stress of proximal AA by 40% while the corresponding increase due to in-plane motion was always below 5%. The stresses at proximal AA resulted approximately 7% less in FSI simulation with blood flow. Conclusions The AR in-plane motion was comparable with the magnitude of axial motion. Neither axial nor in-plane motion could directly lead to AA dissection. It is necessary to consider the heterogeneous pressures related to blood hydrodynamics when studying aortic wall stress levels.
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- 2019
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6. Experimental assessment of cervical ranges of motion and compensatory strategies
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Céline Niewiadomski, Rohan-Jean Bianco, Sanae Afquir, Morgane Evin, and Pierre-Jean Arnoux
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Rotation ,Cervical motion ,Compensatory motion ,Motion pattern ,Motion strategy ,Experimental ,Chiropractic ,RZ201-275 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Literature is still limited regarding reports of non-invasive assessment of the cervical range of motion in normal subjects. Investigations into compensatory motions, defined as the contribution of an additional direction to the required motion, are also limited. The objectives of this work were to develop and assess a reliable method for measuring the cervical range of motion in order to investigate motion and compensatory strategies. Methods and data collection Ninety-seven no neck-related pain subjects (no severe cervical pathology, 57 women, age: 28.3 ± 7.5y. old, BMI: 22.5 ± 3.2 kg/m2) underwent a non-invasive cervical range of motion assessment protocol. In-vivo head’s motion relative to the thorax was assessed through the measurement of the main angular amplitudes in the 3 directions (flexion/extension, axial rotations and lateral inclinations) and associated compensatory motions using an opto-electronic acquisition system. Results The principal motion reproducibility resulted in intra-class correlation coefficients ranging from 0.81 to 0.86. The following maximum ranges of motion were found: 127.4 ± 15.1° of flexion/extension, 89.3 ± 12° of lateral inclinations and 146.4 ± 13° of axial rotations after 6 outlier exclusions. Compensatory motions highly depend on the associated principal motion: for flexion/extension: (3.5 ± 7.6;-2.1 ± 7.8°), for rotation: (25.7 ± 17.9°;0.4 ± 4.7)°, for inclination: (22.9 ± 34.7°;-0.04 ± 8.7°). Age, BMI and weight significantly correlated with flexions (p
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- 2019
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7. Effect of experimental, morphological and mechanical factors on the murine spinal cord subjected to transverse contusion: A finite element study.
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Marion Fournely, Yvan Petit, Eric Wagnac, Morgane Evin, and Pierre-Jean Arnoux
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Medicine ,Science - Abstract
Finite element models combined with animal experimental models of spinal cord injury provides the opportunity for investigating the effects of the injury mechanism on the neural tissue deformation and the resulting tissue damage. Thus, we developed a finite element model of the mouse cervical spinal cord in order to investigate the effect of morphological, experimental and mechanical factors on the spinal cord mechanical behavior subjected to transverse contusion. The overall mechanical behavior of the model was validated with experimental data of unilateral cervical contusion in mice. The effects of the spinal cord material properties, diameter and curvature, and of the impactor position and inclination on the strain distribution were investigated in 8 spinal cord anatomical regions of interest for 98 configurations of the model. Pareto analysis revealed that the material properties had a significant effect (p
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- 2020
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8. Differentiation and quantification of fibrosis, fat and fatty fibrosis in human left atrial myocardium using ex vivo MRI.
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Khaoula Bouazizi, Amer Rahhal, Slawomir Kusmia, Morgane Evin, Carine Defrance, Philippe Cluzel, Myriam Berthet, Fabrice Atassi, Pascal Leprince, Guillaume Lebreton, Nadjia Kachenoura, Stéphane N Hatem, and Alban Redheuil
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Medicine ,Science - Abstract
BACKGROUND:Atrial fibrillation is associated with an atrial cardiomyopathy composed mainly of fibrosis and adipose tissue accumulation. We hypothesized that MRI, when used in an optimal ex vivo setting allowing high spatial resolution without motion artifacts, can help characterizing the complex 3D left atrial (LA) wall composition in human myocardial samples, as compared to histology. METHODS:This prospective case-control study was approved by the institutional review board. 3D MRI acquisitions including saturation-recovery T1 mapping and DIXON imaging was performed at 4.0 T on 9 human LA samples collected from patients who underwent cardiac surgery. Histological quantification of fibrosis and fat was obtained. MRI T1 maps were clustered based on a Gaussian Mixture Model allowing quantification of total, interstitial and fatty fibrosis components. Fat maps were computed from DIXON images and fat fractions were calculated. MRI measurements were performed on the same location as the histological analysis (plane) and on the entire sample volume (3D). RESULTS:High correlations and levels of agreement were observed between MRI and histology for total (r = 0.93), interstitial (r = 0.93) and fatty fibrosis (r = 0.98) and fat (r = 0.96). Native T1 correlated with the amount of fibrosis from MRI and histology. The 3D MRI total, interstitial and fatty fibrosis ranges were between 6% and 23%, 4% and 17.3%; and 1.4% and 19.7% respectively. CONCLUSION:High Field ex vivo MRI was able to quantify different LA myocardial components with high agreement in 2D with histology and moreover to provide 3D quantification of such components whereas in vivo application remains a challenge.
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- 2018
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9. Assessment of the tolerance angle for pedicle screw insertion.
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Lugdivine Leblond, Yves Godio-Raboutet, Yann Glard, Raphael La Greca, Thomas Clement, and Morgane Evin
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- 2024
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10. Detection of functional state after alcohol consumption by classification and machine learning technics.
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Morgane Evin, Joffrey Taillard, Hugo Loeches De la Fuente, Edith Galy, and Catherine Berthelon
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- 2018
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11. Scan-rescan reproducibility of ventricular and atrial MRI feature tracking strain.
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Jérôme Lamy, Gilles Soulat, Morgane Evin, Adrian Huber, Alain De Cesare, Alain Giron, Benoit Diebold, Alban Redheuil, élie Mousseaux, and Nadjia Kachenoura
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- 2018
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12. Left atrium MRI 4D-flow in atrial fibrillation: association with LA function.
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Morgane Evin, Fraser M. Callaghan, Carine Defrance, Stuart M. Grieve, Alain De Cesare, Philippe Cluzel, Alban Redheuil, and Nadjia Kachenoura
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- 2015
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13. Inter-study Repeatability of Left Ventricular Strain Measurement Using Feature Tracking on MRI Cine Images.
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Jérôme Lamy, Gilles Soulat, Alban Redheuil, Morgane Evin, élie Mousseaux, and Nadjia Kachenoura
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- 2015
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14. Biomechanical evaluation of Back injuries during typical snowboarding backward falls
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Wei Wei, Morgane Evin, Nicolas Bailly, Pierre‐Jean Arnoux, Laboratoire de Biomécanique Appliquée (LBA UMR T24), and Aix Marseille Université (AMU)-Université Gustave Eiffel
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[SPI]Engineering Sciences [physics] ,multi-body ,multi- body ,back protection ,finite element ,snowboarding ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,biomechanics - Abstract
International audience; To prevent spinal and back injuries in snowboarding, back protector devices (BPDs) have been increasingly used. The biomechanical knowledge for the BPD design and evaluation remains to be explored in snowboarding accident conditions. This study aims to evaluate back-to-snow impact conditions and the associated back injury mechanisms in typical snowboarding backward falls. A previously validated snowboarder multi-body model was first used to evaluate the impact zones on the back and the corresponding impact velocities in a total of 324 snowboarding backward falls. The biomechanical responses during back-to-snow impacts were then evaluated by applying the back-to-snow impact velocity to a full human body finite element model to fall on the snow ground of three levels of stiffness (soft, hard, and icy snow). The mean values of back-to-snow normal and tangential impact velocities were 2.4 m/s and 7.3 m/s with maximum values up to 4.8 m/s and 18.5 m/s. The lower spine had the highest normal impact velocity during snowboarding backward falls. The thoracic spine was found more likely to exceed the limits of flexion-extension range of motions than the lumbar spine during back-to-snow impacts, indicating a higher injury risk. On the hard and icy snow, rib cage and vertebral fractures were predicted at the costal cartilage and the posterior elements of the vertebrae. Despite the possible back injuries, the back-to-snow impact force was always lower than the force thresholds of the current BPD testing standard. The current work provides additional biomechanical knowledge for the future design of back protections for snowboarders.
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- 2023
15. The Differential Meaning of LV and LA Strains in Aortic Valve Stenosis: A Feature Tracking MRI Study.
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Jérôme Lamy, Gilles Soulat, Morgane Evin, Khaoula Bouazizi-Verdier, Alain Giron, Alban Redheuil, élie Mousseaux, and Nadjia Kachenoura
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- 2017
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16. Pixel-wise absolute pressures in the aortic arch from 3D MRI velocity data and carotid artery applanation tonometry.
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Ioannis Bargiotas, Alban Redheuil, Morgane Evin, Alain De Cesare, Emilie Bollache, Gilles Soulat, élie Mousseaux, and Nadjia Kachenoura
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- 2014
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17. Traction mechanical characterization of porcine mitral valve annulus
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W. Silva-Verissimo, F. El Louali, Y. Godio-Raboutet, Lugdivine Leblond, Joevin Sourdon, S. Rapacchi, and Morgane Evin
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Rehabilitation ,Biomedical Engineering ,Biophysics ,Orthopedics and Sports Medicine - Abstract
The Mitral Annulus (MA) is an anisotropic, fibrous, flexible and dynamical structure. While MA dynamics are well documented, its passive mechanical properties remain poorly investigated to complete the design of adequate prostheses. Mechanical properties in traction on four sections of the MA (aortic, left, posterior and right segments) were assessed using a traction test system with a 30 N load cell and pulling jaws for sample fixation. Samples were submitted to a 1.5 N pre-load, 10 pre-conditioning cycles. Three strain rates were tested (5 %/min, 7 %/min and 13 %/min), the first two up to 10 % strain and the last until rupture. High-resolution diffusion-MRI provided microstructural mapping of fractional anisotropy and mean diffusion within muscle and collagen fibres. Ten MA from porcine hearts were excised resulting in 40 tested samples, out of which 28 were frozen prior to testing. Freezing samples significantly increased Young Moduli for all strain rates. No significant differences were found between Young Moduli at different strain rates (fresh samples 2.4 ± 1.1 MPa, 3.8 ± 2.2 MPa and 3.1 ± 1.8 MPa for increasing strain rates in fresh samples), while significant differences were found when comparing aortic with posterior and posterior with lateral (p 0.012). Aortic segments deformed the most (24.1 ± 9.4 %) while lateral segments endured the highest stress (0.3 MPa), corresponding to higher collagen fraction (0.46) and fractional anisotropy. Passive machinal properties differed between aortic and lateral segments of the MA. The process of freezing samples altered their mechanical properties. Underlying microstructural differences could be linked to changes in strain response.
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- 2022
18. Influence of the scale reduction in designing sockets for trans-tibial amputees
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Tang Liu, Fuhao Mo, Nawfal Dakhil, Maxime Llari, Laurent Thefenne, Michel Behr, Morgane Evin, Tristan Tarrade, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, College of Mechanical and Vehicle Engineering, Hunan University, Service de Médecine Physique et Réadaptation, Hôpital Laveran, and The Second Xiangya Hospital, Central South University
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Male ,030506 rehabilitation ,medicine.medical_specialty ,medicine.medical_treatment ,0206 medical engineering ,Artificial Limbs ,02 engineering and technology ,Prosthesis Design ,Prosthesis ,BIOMECANIQUE ,03 medical and health sciences ,Physical medicine and rehabilitation ,Amputees ,Lower limb amputation ,medicine ,Humans ,GENOU ,Reduction (orthopedic surgery) ,PROTHESE ,Tibia ,business.industry ,Mechanical Engineering ,Amputation Stumps ,General Medicine ,Trans tibial ,TRANSTIBIAL AMPUTEE ,SENSIBILITE ,equipment and supplies ,020601 biomedical engineering ,ARTIFICIAL PROSTHETIC LOWER LIMBS ,body regions ,FINITE ELEMENT MODEL ,CHIRURGIE ,Quality of Life ,MEMBRE INFERIEUR ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,0305 other medical science ,business ,Residual limb - Abstract
The development of artificial prosthetic lower limbs aims to improve patient’s mobility while avoiding secondary problems resulting from the use of the prostheses themselves. The residual limb is a pressure-sensitive area where skin injuries and pain are more likely to develop. Requirements for adequate prosthetic limbs have now become urgent to improve amputee’s quality of life. This study aims to understand how socket design parameters related to geometry can influence pressure distribution in the residual limb. A finite element model was developed to simulate the mechanical loading applied on the residual limb of a below-knee amputee while walking. A sensitivity analysis to socket initial geometry, scaling the socket downward in the horizontal plane, was performed. Recordings include stress levels on the skin and in the residual limb deep soft tissues. Peak stress was reduced by up to 51% with a limited reduction of the socket size. More important scale reduction of the residual limb would lead to possible negative effects, such as stress concentrations in sensitive areas. This result confirms the interest of the prosthetist to develop a well-fitting socket, possibly a little smaller than the residual limb itself, in order to avoid residual limb mobility in the socket that could cause friction and stress concentrations. Non-homogeneous geometrical reductions of the socket should be further investigated.
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- 2020
19. Is skin pressure a relevant factor for socket assessment in patients with lower limb amputation?
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Maxime Llari, Laurent Thefenne, Michel Behr, Fuhao Mo, Morgane Evin, Nawfal Dakhil, Tang Liu, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Laboratoire d'Imagerie Biomédicale (LIB), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,0206 medical engineering ,Biomedical Engineering ,Biophysics ,Pain ,Artificial Limbs ,Health Informatics ,Bioengineering ,02 engineering and technology ,Prosthesis ,Amputation, Surgical ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Physical medicine and rehabilitation ,Amputation, Traumatic ,Quality of life ,Lower limb amputation ,Surveys and Questionnaires ,Pressure ,medicine ,Quantitative assessment ,Humans ,In patient ,ComputingMilieux_MISCELLANEOUS ,Skin ,Leg ,Pain score ,Rehabilitation ,business.industry ,Amputation Stumps ,[SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph] ,020601 biomedical engineering ,Phantom Limb ,business ,030217 neurology & neurosurgery ,Information Systems - Abstract
Background Prosthetic rehabilitation improves the overall quality of life of patients, despite discomfort and medical complications. No quantitative assessment of prosthesis-patient interaction is used in routine protocols and prosthesis quality still results from the manufacturer's know-how. Objective Our objective is to investigate whether pressure can be a relevant factor for assessing socket adequacy. Methods A total of 8 transtibial amputee volunteers took part in this experimental study. The protocol included static standing and 2 minutes walking tests while the stump-to-socket interface pressures were measured. Questionnaires on comfort and pain were also conducted. Results During static standing test, maximum pressures were recorded in the proximal region of the leg, with a peak value reaching 121.1 ± 31.6 kPa. During dynamic tests, maximum pressures of 254.1 ± 61.2 kPa were recorded during the loading phase of the step. A significant correlation was found between the pain score and static maximum recorded pressure (r= 0.81). Conclusions The protocol proposed and evaluated in this study is a repeatable, easy-to-set quantified analysis of the patient to socket interaction while standing and walking. This approach is likely to improve feedback for prosthesis manufacturers and consequently the overall design of prostheses.
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- 2019
20. Experimental Bi-axial tensile tests of spinal meningeal tissues and constitutive models comparison
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Yannick Tillier, Pierre-Jean Arnoux, Yves Godio-Raboutet, Éric Wagnac, Patrice Sudres, Morgane Evin, Pascal Weber, Yvan Petit, Centre de Mise en Forme des Matériaux (CEMEF), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Mines Paris - PSL (École nationale supérieure des mines de Paris), Laboratoire de Biomécanique Appliquée (LBA UMR T24), and Aix Marseille Université (AMU)-Université Gustave Eiffel
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Materials science ,Swine ,0206 medical engineering ,Population ,Constitutive equation ,Biomedical Engineering ,Context (language use) ,02 engineering and technology ,Biochemistry ,[SPI.MAT]Engineering Sciences [physics]/Materials ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Elastic Modulus ,Tensile Strength ,medicine ,Animals ,Composite material ,education ,[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials ,Molecular Biology ,Elastic modulus ,ComputingMilieux_MISCELLANEOUS ,education.field_of_study ,Pia mater ,Linear elasticity ,Isotropy ,Biaxial tensile test ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,General Medicine ,020601 biomedical engineering ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,Biomechanical Phenomena ,medicine.anatomical_structure ,Anisotropy ,Pia Mater ,Stress, Mechanical ,Arachnoid ,030217 neurology & neurosurgery ,Biotechnology - Abstract
Introduction This study aims at identifying mechanical characteristics under bi-axial loading conditions of extracted swine pia mater (PM) and dura and arachnoid complex (DAC). Methods 59 porcine spinal samples have been tested on a bi-axial experimental device with a pre-load of 0.01 N and a displacement rate of 0.05 mm.s−1. Post-processing analysis included an elastic modulus, as well as constitutive model identification for Ogden model, reduced Gasser Ogden Holzapfel (GOH) model, anisotropic GOH model, transverse isotropic and anisotropic Gasser models as well as a Mooney-Rivlin model including fiber strengthening for PM. Additionally, micro-structure of the tissue was investigated using a bi-photon microscopy. Results Linear elastic moduli of 108±40 MPa were found for DAC longitudinal direction, 53±32 MPa for DAC circumferential direction, with a significant difference between directions (p Statement of Significance This study is the first to present biaxial tensile test of pia mater as well as constitutive model comparisons for dura and arachnoid complex tissue based on such tests. Collagen structures observed by semi-quantitative analysis of two photon microscopy confirmed the use of anisotropic Gasser model for pia mater and existence of fenestration. While clear identification of fibre population was not possible in DAC, results from anisotropic Gasser model depicted better fitting on experimental data as per this protocol. Bi-axial mechanical testing allows quasi-static characterization under conditions closr to the physiological context and the results presented could be used for further simulations of physiology. Indeed, the inclusion of meningeal tissue in finite element models will allow more accurate and reliable numerical simulations.
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- 2021
21. Correction: Acquired Spinal Conditions in Evolutionary Perspective: Updating a Classic Hypothesis
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Mark Collard, Kimberly A. Plomp, Keith M. Dobney, Morgane Evin, Ella Been, Kanna Gnanalingham, Paulo Ferreira, Milena Simic, and William Sellers
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History and Philosophy of Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
22. Tensile mechanical properties of the cervical, thoracic and lumbar porcine spinal meninges
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Anthony Melot, Lucien Diotalevi, Nicolas Bailly, Éric Wagnac, Pierre-Jean Arnoux, Patrice Sudres, Yvan Petit, Morgane Evin, Laboratoire de Biomécanique Appliquée (LBA UMR T24), and Aix Marseille Université (AMU)-Université Gustave Eiffel
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Cord ,Swine ,Biomedical Engineering ,02 engineering and technology ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Meninges ,Elastic Modulus ,medicine ,Animals ,Spinal canal ,Spinal Meninges ,ComputingMilieux_MISCELLANEOUS ,Pia mater ,business.industry ,Biomechanics ,030206 dentistry ,Anatomy ,[SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph] ,021001 nanoscience & nanotechnology ,Spinal cord ,medicine.anatomical_structure ,Spinal Cord ,Mechanics of Materials ,Pia Mater ,Dura Mater ,Stress, Mechanical ,0210 nano-technology ,business - Abstract
Background The spinal meninges play a mechanical protective role for the spinal cord. Better knowledge of the mechanical behavior of these tissues wrapping the cord is required to accurately model the stress and strain fields of the spinal cord during physiological or traumatic motions. Then, the mechanical properties of meninges along the spinal canal are not well documented. The aim of this study was to quantify the elastic meningeal mechanical properties along the porcine spinal cord in both the longitudinal direction and in the circumferential directions for the dura-arachnoid maters complex (DAC) and solely in the longitudinal direction for the pia mater. This analysis was completed in providing a range of isotropic hyperelastic coefficients to take into account the toe region. Methods Six complete spines (C0 – L5) were harvested from pigs (2–3 months) weighing 43±13 kg. The mechanical tests were performed within 12 h post mortem. A preload of 0.5 N was applied to the pia mater and of 2 N to the DAC samples, followed by 30 preconditioning cycles. Specimens were then loaded to failure at the same strain rate 0.2 mm/s (approximately 0.02/s, traction velocity/length of the sample) up to 12 mm of displacement. Results The following mean values were proposed for the elastic moduli of the spinal meninges. Longitudinal DAC elastic moduli: 22.4 MPa in cervical, 38.1 MPa in thoracic and 36.6 MPa in lumbar spinal levels; circumferential DAC elastic moduli: 20.6 MPa in cervical, 21.2 MPa in thoracic and 12.2 MPa in lumbar spinal levels; and longitudinal pia mater elastic moduli: 18.4 MPa in cervical, 17.2 MPa in thoracic and 19.6 MPa in lumbar spinal levels. Discussion The variety of mechanical properties of the spinal meninges suggests that it cannot be regarded as a homogenous structure along the whole length of the spinal cord.
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- 2021
23. Biomechanical comparison of spinal cord compression types occurring in Degenerative Cervical Myelopathy
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Pierre-Hugues Roche, Virginie Callot, Morgane Evin, Guillaume Baucher, Pierre-Jean Arnoux, Simon Lévy, Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), iLab-Spine - Laboratoire international en imagerie et biomécanique du Rachis, Hôpital Nord [CHU - APHM], International Laboratory on Spine Imaging and Biomechanics (iLab-Spine), Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), ANR-11-INBS-0006,FLI,France Life Imaging(2011), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM] (CEMEREM), and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE)
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Male ,Cord ,Herniated disk ,[SDV]Life Sciences [q-bio] ,Biophysics ,Spinal cord compression ,Spinal Cord Diseases ,White matter ,03 medical and health sciences ,Myelopathy ,Ligamentum flavum hypertrophy ,[SPI]Engineering Sciences [physics] ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Spinal canal ,Finite element modeling ,Degenerative cervical myelopathy ,Mechanical Phenomena ,Spinal cord ,business.industry ,030229 sport sciences ,Anatomy ,medicine.disease ,Compression (physics) ,Magnetic Resonance Imaging ,Biomechanical Phenomena ,medicine.anatomical_structure ,Cervical Vertebrae ,Female ,business ,030217 neurology & neurosurgery - Abstract
International audience; BackgroundDegenerative Cervical Myelopathy results from spine degenerations narrowing the spinal canal and inducing cord compressions. Prognosis is challenging. This study aimed at simulating typical spinal cord compressions observed in patients with a realistic model to better understand pathogenesis for later prediction of patients' evolution.MethodsA 30% reduction in cord cross-sectional area at C5-C6 was defined as myelopathy threshold based on Degenerative Cervical Myelopathy features from literature and MRI measurements in 20 patients. Four main compression types were extracted from MRIs and simulated with a comprehensive three-dimensional finite element spine model. Median diffuse, median focal and lateral types were modelled as disk herniation while circumferential type additionally involved ligamentum flavum hypertrophy. All stresses were quantified along inferior-superior axis, compression development and across atlas-defined spinal cord regions.FindingsAnterior gray and white matter globally received the highest stress while lateral pathways were the least affected. Median diffuse compression induced the highest stresses. Circumferential type focused stresses in posterior gray matter. Along inferior-superior axis, those two types showed a peak of constraints at compression site while median focal and lateral types showed lower values but extending further.InterpretationMedian diffuse type would be the most detrimental based on stress amplitude. Anterior regions would be the most at risk, except for circumferential type where posterior regions would be equally affected. In addition to applying constraints, ischemia could be a significant component explaining the early demyelination reported in lateral pathways. Moving towards patient-specific simulations, biomechanical models could become strong predictors for degenerative changes.
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- 2020
24. Cervical Canal Morphology: Effects of Neck Flexion in Normal Condition: New Elements for Biomechanical Simulations and Surgical Management
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Morgane Evin, Pierre-Jean Arnoux, Virginie Callot, Patrice Sudres, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, International Laboratory on Spine Imaging and Biomechanics (iLab-Spine), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Exploration Métabolique par Résonance Magnétique [Marseille] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)
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Adult ,Male ,Supine position ,ARTICULATION HUMAINE ,Population ,SPINAL CORD (SC) ,Posture ,FLEXION ,CERVICAL SUBARACHNOID SPACE (CSS) ,03 medical and health sciences ,Neutral neck position ,BIOMECANIQUE ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Denticulate ligaments ,MOELLE EPINIERE ,Range of Motion, Articular ,education ,Cervical canal ,030222 orthopedics ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,COU ,3D reconstruction ,VERTEBRE CERVICALE ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,Cervical Cord ,Magnetic resonance imaging ,Middle Aged ,Spinal cord ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Spinal Cord ,COLONNE VERTEBRALE ,CHIRURGIE ,Cervical Vertebrae ,MORPHOLOGY ,Female ,Neurology (clinical) ,Nuclear medicine ,business ,Spinal Canal ,030217 neurology & neurosurgery ,Neck ,MOUVEMENT - Abstract
STUDY DESIGN Continuous measurements and computation of absolute metrics of cervical subarachnoid space (CSS) and spinal cord (SC) geometries proposed are based on in vivo magnetic resonance imaging and 3D reconstruction. OBJECTIVE The aim of the study is to offer a new methodology to continuously characterize and to quantify the detailed morphology of the CSS and the cervical SC in 3D for healthy subjects in both neutral supine and flexion. SUMMARY OF BACKGROUND DATA To the best of our knowledge, no study provides a morphological quantification by absolute indices based on the 3D reconstruction of SC and CSS thanks to in vivo magnetic resonance imaging. Moreover, no study provides a continuous description of the geometries. METHODS Absolute indices of SC (cross-sectional area, compression ratio, position in the canal, length) and of CSS (cross-sectional area, occupational ratio, lengths) were computed by measures from 3D semi-automatic reconstructions of high resolution in vivo magnetic resonance images (3D T2-SPACE sequence) on healthy subjects (N = 11) for two postures: supine neutral and flexion neck positions. The variability induced by the semi-automatic reconstruction and by the landmarks positioning were investigated by preliminary sensitivity analyses. Inter and intra-variability were also quantified on a randomly chosen part of our population (N = 5). RESULTS The length and cross-sectional area of SC are significantly different (P
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- 2020
25. Isometric osteopathic manipulation influences on cervical ranges of motion and correlation with osteopathic palpatory diagnosis: A randomized trial
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Morgane Evin, Céline Niewiadomski, Pierre-Jean Arnoux, Rohan-Jean Bianco, Cadic, Ifsttar, Collège d'Ostéopathie de Provence, Aix en Provence, France, Laboratoire de Biomécanique Appliquée (LBA UMR T24), and Aix Marseille Université (AMU)-Université Gustave Eiffel
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Complementary and Manual Therapy ,Adult ,Male ,medicine.medical_specialty ,ARTICULATION HUMAINE ,Isometric exercise ,Placebo ,law.invention ,Correlation ,MEDECINE ,03 medical and health sciences ,Young Adult ,BIOMECANIQUE ,0302 clinical medicine ,Randomized controlled trial ,law ,Isometric Contraction ,[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,Medicine ,Humans ,030212 general & internal medicine ,RANGE OF MOTION ,Range of Motion, Articular ,Advanced and Specialized Nursing ,PLACEBO ,business.industry ,COU ,VERTEBRE CERVICALE ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,MUSCULOSKELETAL MANIPULATIONS ,Manipulation, Osteopathic ,3. Good health ,Biomechanical Phenomena ,Osteopathic manipulation ,Complementary and alternative medicine ,Palpatory diagnosis ,Osteopathy ,THERAPEUTICS ,COLONNE VERTEBRALE ,Physical therapy ,Cervical Vertebrae ,ROTATION ,Female ,business ,Range of motion ,030217 neurology & neurosurgery ,SPINE ,MOUVEMENT - Abstract
Introduction Isometric manipulation is a current practice in osteopathy and treatment benefits have been reported in the literature. Such benefits could be assessed using experimental non-invasive cervical mobility measurements. The main objective was to quantitatively measure the effects of isometric manipulation on principal and compensatory cervical motions. Methods 101 healthy volunteers were included in this study. 51 healthy volunteers selected randomly underwent the experimental protocol before and after isometric treatment and were compared to 50 healthy volunteers who underwent a placebo treatment. Osteopathic diagnosis was performed on each healthy volunteer before and after the treatment. The experimental protocol included measurements by a motion capture system focusing on principal range of motion and compensatory motions. Results In both the isometric and the placebo sample, respectively including 51 (age: 29.2 ± 8.1, BMI: 22.2 ± 3.5) and 50 healthy volunteers (age: 27.4 ± 6.8, BMI: 22.9 ± 2.8), a pre-treatment diagnosis revealed a light cervical dysfunction in all subjects, mainly in levels C3 and C4. Altered ranges of motion thresholds (C3/C4 alterations) were identified: 113.2° for flexion, 130.0° for rotation and 90.2° for lateral flexion. After manipulations, the volunteers who underwent the isometric treatment presented a slight increase in amplitude for lateral flexion (p \textless 0.04), which was not found in the volunteers who underwent the placebo treatment. Compensatory motions showed differences pre and post isometric treatment without reaching significant values. Conclusion Principal ranges of motion were found significantly higher after osteopathic treatment when compared to the placebo treatment. Osteopathic palpatory diagnosis showed significant correlation with range of motions before treatment.
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- 2020
26. Investigating heartbeat-related in-plane motion and stress levels induced at the aortic root
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Frank Kober, Wei Wei, Monique Bernard, Stanislas Rapacchi, Michel Behr, Morgane Evin, Alexis Jacquier, Cyril J.F. Kahn, Institute for Advanced Study [Tsinghua], Tsinghua University [Beijing] (THU), Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Rapacchi, Stanislas, Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
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Adult ,Male ,lcsh:Medical technology ,Heartbeat ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,medicine.medical_treatment ,Aortic root ,Movement ,0206 medical engineering ,Finite Element Analysis ,Biomedical Engineering ,02 engineering and technology ,Biomaterials ,Finite element ,medicine.artery ,Fluid–structure interaction ,Ascending aorta ,Fluid-structure interaction ,medicine ,Image Processing, Computer-Assisted ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Aorta ,Physics ,[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] ,Radiological and Ultrasound Technology ,Aortic root motion ,Magnetic resonance imagining ,Research ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,Heart ,General Medicine ,Blood flow ,Aortic stress ,Traction (orthopedics) ,020601 biomedical engineering ,Magnetic Resonance Imaging ,Finite element method ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,surgical procedures, operative ,lcsh:R855-855.5 ,Descending aorta ,cardiovascular system ,[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] ,Female ,Stress, Mechanical ,Biomedical engineering - Abstract
Background The axial motion of aortic root (AR) due to ventricular traction was previously suggested to contribute to ascending aorta (AA) dissection by increasing its longitudinal stress, but AR in-plane motion effects on stresses have never been studied. The objective is to investigate the contribution of AR in-plane motion to AA stress levels. Methods The AR in-plane motion was assessed on magnetic resonance imagining data from 25 healthy volunteers as the movement of the AA section centroid. The measured movement was prescribed to the proximal AA end of an aortic finite element model to investigate its influences on aortic stresses. The finite element model was developed from a patient-specific geometry using LS-DYNA solver and validated against the aortic distensibility. Fluid–structure interaction (FSI) approach was also used to simulate blood hydrodynamic effects on aortic dilation and stresses. Results The AR in-plane motion was 5.5 ± 1.7 mm with the components of 3.1 ± 1.5 mm along the direction of proximal descending aorta (PDA) to AA centroid and 3.0 ± 1.3 mm perpendicularly under the PDA reference system. The AR axial motion elevated the longitudinal stress of proximal AA by 40% while the corresponding increase due to in-plane motion was always below 5%. The stresses at proximal AA resulted approximately 7% less in FSI simulation with blood flow. Conclusions The AR in-plane motion was comparable with the magnitude of axial motion. Neither axial nor in-plane motion could directly lead to AA dissection. It is necessary to consider the heterogeneous pressures related to blood hydrodynamics when studying aortic wall stress levels. Electronic supplementary material The online version of this article (10.1186/s12938-019-0632-7) contains supplementary material, which is available to authorized users.
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- 2019
27. A modelisation of quantification of head and neck risks associated with tackles in rugby union
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Lionel Thollon, Maxime Llari, Wei Wei, A. Forodighasemabadi, L. Cogoluenhes, Morgane Evin, Laboratoire de Biomécanique Appliquée (LBA UMR T24), and Aix Marseille Université (AMU)-Université Gustave Eiffel
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medicine.medical_specialty ,Multi body ,MULTI-BODY ,ARTICULATION HUMAINE ,education ,0206 medical engineering ,Biomedical Engineering ,Bioengineering ,02 engineering and technology ,RUGBY ,GRAVITE DES BLESSURES ,SPORT ,ANATOMIE ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,TETE ,medicine ,CERVEAU ,BLESSURE ,Head and neck ,TACKLES INJURY RISK ,business.industry ,COU ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,030229 sport sciences ,General Medicine ,020601 biomedical engineering ,Computer Science Applications ,Human-Computer Interaction ,business - Abstract
44th Congress of the Société de Biomécanique, Poitiers, FRANCE, 28-/10/2019 - 30/10/2019; Recent news in Rugby Union highlight the necessity to prevent concussions and injuries during training and matches. The number of concussions has indeed been reported to increase in the last decades (Finch et al. 2013). This is mostly due to the anatomy of professional rugby players (muscular development, higher body mass index- BMI).While the rugby union rules have been changing to promote safer practice in scrum, the players get highly injured during tackles (Fuller et al. 2010). Multiple influences on injury risks, such as the impact conditions or the player's morphology, have not been fully studied. In tackling, both the tackler (T) and the ball carrier (BC), their morphology and initial position need to be studied to fully describe the tackle impacts. Experimentally, on field data can be acquired with sensors and epidemiological studies have been carried to correlate the type of injury with the impact conditions (Kuster et al. 2012)
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- 2019
28. Influence of the aortic morphological changes in aging on aortic flow
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Michel Behr, Mohammed Amine Bouqentar, Patrice Sudres, Wei Wei, Morgane Evin, Mourad Boufi, Laboratoire de Biomécanique Appliquée (LBA UMR T24), and Aix Marseille Université (AMU)-Université Gustave Eiffel
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Biomedical Engineering ,DYNAMIQUE DES FLUIDES ,Bioengineering ,Dissection (medical) ,030204 cardiovascular system & hematology ,AORTE ,COEUR ,030218 nuclear medicine & medical imaging ,AORTA ,BLOOD AORTIC FLOW ,AGING ,03 medical and health sciences ,Global population ,0302 clinical medicine ,Aneurysm ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,medicine.artery ,Ascending aorta ,medicine ,Shear stress ,CARDIOVASCULAR DISEASES (CVD) ,Body surface area ,Aorta ,PRESSION ARTERIELLE ,business.industry ,SANG ,General Medicine ,Aortic flow ,Anatomy ,medicine.disease ,COMPUTATIONAL FLUID DYNAMICS (CFD) ,3. Good health ,Computer Science Applications ,VIEILLISSEMENT ,Human-Computer Interaction ,ARTERE ,CHIRURGIE ,cardiovascular system ,business - Abstract
44th Congress of the Société de Biomécanique, Poitiers, FRANCE, 28-/10/2019 - 30/10/2019; With aging of the global population, the number of aortic flow related cardiovascular diseases (CVD) as aneurysm, dissection and atherosclerosis are increasing (Craiem et al. 2017). In such pathologies the part of the flow in the physio-pathological mechanism has still to be described and proven. In aneurysm, wall shear stress changes have been shown to be related to occurrence of burst (Vorp 2007). Additionally, wall shear stress has also been proven to be correlated with the changes in aortic tissue in ascending aorta (van Ooij et al. 2015; Lantz et al. 2011). In dissection, a study has revealed that the increase in WSS was related to alterations of the aortic morphology (Chi et al. 2017). The morphology of aorta as well as material properties of the wall changes with gender, age and body Surface Area (Biaggi et al. 2009). However the current aortic flow simulations rarely take into account the changes in the morphology (van Ooij et al. 2016). Additionally in vascular and thoracic surgery, description of the aortic morphology through a centreline has enable to describe a normal morphology according with the patient data. Aortic shapes description has also involved architectural concept as Gothic arch (Ou et al. 2006).
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- 2019
29. Sacroiliac joint morphologic changes from infancy to adulthood
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Roxanne Dubé-Cyr, Pierre-Jean Arnoux, Jean-Marc Vital, Pierre Coudert, Jean-Luc Jouve, Olivier Gille, Morgane Evin, Kathia Chaumoitre, Michel Panuel, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Service d'Orthopédie Traumatologie, Spine Unit 1, CHU de Bordeaux, Hôpital Pellegrin, Bordeaux, France, École Polytechnique de Montréal, Montréal, Canada, Service de Chirurgie Orthopédique et Traumatologique Pédiatrique, Hôpital de la Timone, CHU de Marseille, Marseille, France, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Cadic, Ifsttar, INRA - Mathématiques et Informatique Appliquées (Unité MIAJ), Institut National de la Recherche Agronomique (INRA), Bordeaux University Hospital, University Hospital, Service d'Orthopédie Pédiatrique, Université de la Méditerranée - Aix-Marseille 2, Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), UMR 6578 : Anthropologie Bio-Culturelle (UAABC), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Biomédicale (LIB), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), ISOARDI, Audrey, Laboratoire de Biomécanique Appliquée, and Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux, IFSTTAR-Aix Marseille Université, AMU
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Male ,ARTICULATION HUMAINE ,Computed tomography ,[SPI.MECA.MEFL] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,PELVIC INCIDENCE ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,0302 clinical medicine ,[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,CROISSANCE ,Orthopedics and Sports Medicine ,SACRO-ILIAC JOINT ,Child ,ComputingMilieux_MISCELLANEOUS ,Sacroiliac joint ,Orthodontics ,030222 orthopedics ,medicine.diagnostic_test ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,Middle Aged ,medicine.anatomical_structure ,[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system ,Child, Preschool ,GROWTH ,Female ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Patient database ,Adult ,Adolescent ,Context (language use) ,ANATOMIE ,03 medical and health sciences ,BIOMECANIQUE ,Sex Factors ,medicine ,Humans ,[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,business.industry ,Infant ,Pelvic incidence ,Sacroiliac Joint ,Sacrum ,Orientation analysis ,COLONNE VERTEBRALE ,MORPHOLOGY ,Surgery ,Neurology (clinical) ,Tomography, X-Ray Computed ,business ,030217 neurology & neurosurgery ,SPINE - Abstract
Report of sacroiliac morphology changes during growth is limited in the literature and the interest of such morphology and its consequence for surgery is increasing.Aims of this work are (1) to anatomically define the sacroiliac joint (SIJ), and (2) to assess the influence of growth on the sacroiliac morphology and the pelvic parameters.Forty-nine young subjects from 6 months to 18 years old (y/o) and 20 adults aged from 18 to 50 y/o were selected from our institutional patient database.They underwent a computed tomography (CT) examination on a 128-MDCT (GE Healthcare Optima CT660). Transverse CT image datasets were reconstructed, anonymized, and segmented with ITK-SNAP. Landmarks and surfaces were selected and a SIJ orientation analysis was performed using costumed Python scripts.The subjects were divided into four groups: infants (1.9±1 y/o), children (6.9±1.7 y/o), adolescents (13.7±1.8 y/o), and adults (27.3±5.6 y/o). Differences between SIJ orientation were found significant between young subject groups for synovial sacrum SIJ orientation (p.001) and iliac total SIJ orientation (p=.036). Both orientations of younger subjects were found significantly different from the adult group (p.035). SIJ synovial sacrum and iliac total orientations correlated significantly with age (p.03). All orientations correlated with pelvic incidence (p.04) except for synovial sacrum SIJ orientation (p=.2). No gender or symmetrical differences were found significant in any group.Morphologic definition of the SIJ confirmed the independency of the gender during growth. Such results will be beneficial for the analysis and management of vertebral pathology.
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- 2019
30. Stress effects of the cerebrospinal pulsatile flow on the spinal cord by a 3D fluid-structure modeling
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Pierre-Jean Arnoux, Patrice Sudres, Morgane Evin, Laboratoire de Biomécanique Appliquée (LBA UMR T24), and Aix Marseille Université (AMU)-Université Gustave Eiffel
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Stress effects ,0206 medical engineering ,Biomedical Engineering ,Pulsatile flow ,CEREBROSPINAL FLOW ,Bioengineering ,02 engineering and technology ,BIOMECANIQUE ,03 medical and health sciences ,0302 clinical medicine ,CERVEAU ,Medicine ,MOELLE EPINIERE ,business.industry ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,030229 sport sciences ,General Medicine ,SYSTEME NERVEUX ,Spinal cord ,MODELISATION ,020601 biomedical engineering ,Computer Science Applications ,FLUID-STRUCTURE INTERACTION ,Human-Computer Interaction ,medicine.anatomical_structure ,PHYSIOLOGIE ,COLONNE VERTEBRALE ,VON MISES STRESS ,business ,SPINAL CORD ,Biomedical engineering - Abstract
44th Congress of the Société de Biomécanique, Poitiers, FRANCE, 28-/10/2019 - 30/10/2019; The mechanical phenomena which occur in the subarachnoid space have been studied either from a structural point of view particularly focusing on the spinal cord (SC) or from a fluid point of view focusing on the cerebrospinal fluid (CSF) flow. Fluid-structure interaction (FSI) approaches provide new perspectives to numerically describe the physiological phenomenon. It has been showed that the CSF acts in a passively way on the central nervous system as shock absorber in compressive spinal cord injuries (Fradet et al. 2016). However, we are not aware of any study that provide stress values induced by the active physiological role of the pulsatile CSF flow profile on the spinal cord in 3D. The purpose of this study is to quantify the maximum Von Mises stress generated in the spinal cord induced by an healthy pulsatile flow profile of the CSF.
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- 2019
31. Non-invasive thoracic and lumbar spine range of motion by motion acquisition system
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Morgane Evin, Pierre-Jean Arnoux, A. Melot, J. Mignot, and Virginie Callot
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musculoskeletal diseases ,Thorax ,business.industry ,0206 medical engineering ,Non invasive ,Biomedical Engineering ,Bioengineering ,030229 sport sciences ,02 engineering and technology ,General Medicine ,Anatomy ,musculoskeletal system ,020601 biomedical engineering ,Trunk ,Motion (physics) ,Computer Science Applications ,Human-Computer Interaction ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Gait (human) ,Medicine ,Lumbar spine ,Range of motion ,business - Abstract
Trunk range of motion (ROM) could be divided into two anatomical parts: the movements of the thorax and the lumbar spine. The trunk mobility is largely described with gait, but few studies are inte...
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- 2019
32. Assessing the Global Range of Motion of the Helmeted Head Through Rotational and Translational Measurements
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Brieg Lecoublet, D. Boisclair, Yvan Petit, Éric Wagnac, Morgane Evin, Carl-Eric Aubin, Pierre-Jean Arnoux, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Ecole de Technologie Supérieure [Montréal] (ETS), CHU Sainte Justine [Montréal], Laboratoire d'Imagerie Biomédicale (LIB), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
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Computer science ,business.industry ,Mechanical Engineering ,Work (physics) ,[PHYS.MECA.GEME]Physics [physics]/Mechanics [physics]/Mechanical engineering [physics.class-ph] ,020101 civil engineering ,Transportation ,02 engineering and technology ,Motion capture ,Industrial and Manufacturing Engineering ,0201 civil engineering ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Head (vessel) ,Head movements ,Computer vision ,Artificial intelligence ,business ,Range of motion ,ComputingMilieux_MISCELLANEOUS - Abstract
This work aimed to describe the helmeted head mobility as a combination of rotations and translations during functional head movements. A motion capture system was used to follow six optoelectronic...
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- 2019
33. Experimental assessment of cervical ranges of motion and compensatory strategies
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Morgane Evin, Pierre-Jean Arnoux, Rohan-Jean Bianco, Céline Niewiadomski, Sanae Afquir, iLab-Spine - Laboratoire international en imagerie et biomécanique du Rachis, Laboratoire de Biomécanique Appliquée (LBA UMR T24), and Aix Marseille Université (AMU)-Université Gustave Eiffel
- Subjects
Male ,lcsh:Diseases of the musculoskeletal system ,MOTION ANALYSIS ,ARTICULATION HUMAINE ,Kinematics ,Motion (physics) ,Correlation ,MEDECINE ,0302 clinical medicine ,TETE ,030212 general & internal medicine ,Range of Motion, Articular ,CERVICAL RANGE OF MOTION ,Cervical pathology ,Manipulation, Chiropractic ,VERTEBRE CERVICALE ,Middle Aged ,Healthy Volunteers ,Biomechanical Phenomena ,Cervical Vertebrae ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Female ,Rotation (mathematics) ,Cervical range of motion ,Adult ,medicine.medical_specialty ,Rotation ,Non-invasive motion measurements ,Physical Therapy, Sports Therapy and Rehabilitation ,03 medical and health sciences ,Cervical motion ,Experimental ,Physical medicine and rehabilitation ,medicine ,Humans ,Motion strategy ,business.industry ,COU ,Compensatory motion ,Research ,Work (physics) ,Reproducibility of Results ,lcsh:Chiropractic ,Motion pattern ,Complementary and alternative medicine ,lcsh:RZ201-275 ,Chiropractics ,lcsh:RC925-935 ,business ,030217 neurology & neurosurgery ,Neck ,MOUVEMENT - Abstract
Background Literature is still limited regarding reports of non-invasive assessment of the cervical range of motion in normal subjects. Investigations into compensatory motions, defined as the contribution of an additional direction to the required motion, are also limited. The objectives of this work were to develop and assess a reliable method for measuring the cervical range of motion in order to investigate motion and compensatory strategies. Methods and data collection Ninety-seven no neck-related pain subjects (no severe cervical pathology, 57 women, age: 28.3 ± 7.5y. old, BMI: 22.5 ± 3.2 kg/m2) underwent a non-invasive cervical range of motion assessment protocol. In-vivo head’s motion relative to the thorax was assessed through the measurement of the main angular amplitudes in the 3 directions (flexion/extension, axial rotations and lateral inclinations) and associated compensatory motions using an opto-electronic acquisition system. Results The principal motion reproducibility resulted in intra-class correlation coefficients ranging from 0.81 to 0.86. The following maximum ranges of motion were found: 127.4 ± 15.1° of flexion/extension, 89.3 ± 12° of lateral inclinations and 146.4 ± 13° of axial rotations after 6 outlier exclusions. Compensatory motions highly depend on the associated principal motion: for flexion/extension: (3.5 ± 7.6;-2.1 ± 7.8°), for rotation: (25.7 ± 17.9°;0.4 ± 4.7)°, for inclination: (22.9 ± 34.7°;-0.04 ± 8.7°). Age, BMI and weight significantly correlated with flexions (p
- Published
- 2019
34. Spinal injury analysis for typical snowboarding backward falls
- Author
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Maxime Llari, Nicolas Bailly, Pierre-Jean Arnoux, Morgane Evin, Wei Wei, Jean-Dominique Laporte, School of Computer and Electronic Information [Guangxi University], Guangxi University [Nanning], Laboratoire d'Imagerie Biomédicale (LIB), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J), Laboratoire de Biomécanique Appliquée (LBA UMR T24), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Université Gustave Eiffel
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Thoracic spine ,Posture ,Skill level ,Physical Therapy, Sports Therapy and Rehabilitation ,Manikins ,Thoracic Vertebrae ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Skiing ,medicine ,Injury risk ,Humans ,Orthopedics and Sports Medicine ,Range of Motion, Articular ,Spinal injury ,ComputingMilieux_MISCELLANEOUS ,Lumbar Vertebrae ,business.industry ,Lumbosacral Region ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,030229 sport sciences ,Anthropometry ,[SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph] ,musculoskeletal system ,Biomechanical Phenomena ,13. Climate action ,Spinal compression ,Spinal Injuries ,Athletic Injuries ,Lumbar spine ,Accidental Falls ,Range of motion ,business ,human activities ,030217 neurology & neurosurgery - Abstract
Spinal injury (SPI) often causes death and disability in snow-sport accidents. SPIs often result from spinal compression and flexion, but the injury risks due to over flexion have not been studied. Back protectors are used to prevent SPIs but the testing standards do not evaluate the flexion-extension resistance. To investigate SPI risks and to better define back-protector specifications, this study quantified the flexion-extension range of motions (ROMs) of the thoracic-lumbar spine during typical snowboarding backward falls. A human facet-multibody model, which was calibrated against spinal flexion-extension responses and validated against vehicle-pedestrian impact and snowboarding backward fall, was used to reproduce typical snowboarding backward falls considering various initial conditions (initial velocity, slope steepness, body posture, angle of approach, anthropometry, and snow stiffness). The SPI risks were quantified by normalizing the numerical spinal flexion-extension ROMs against the corresponding ROM thresholds from literature. A high risk of SPI was found in most of the 324 accident scenarios. The thoracic segment T6-T7 had the highest injury risk and incidence. The thoracic spine was found more vulnerable than the lumbar spine. Larger anthropometries and higher initial velocities tended to increase SPI risks while bigger angles of approach helped to reduce the risks. SPIs can result from excessive spinal flexion-extension during snowboarding backward falls. Additional evaluation of back protector's flexion-extension resistance should be included in current testing standards. An ideal back protector should consider the vulnerable spinal segments, the snowboarder's skill level and anthropometry.
- Published
- 2018
35. Detection of functional state after alcohol consumption by classification and machine learning technics
- Author
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Hugo Loeches De La Fuente, Catherine Berthelon, Morgane Evin, Edith Galy, Joffrey Taillard, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Laboratoire Mécanismes d'Accidents (IFSTTAR/TS2/LMA), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Laboratoire d'Anthropologie et de Psychologie Cliniques, Cognitives et Sociales (LAPCOS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), RP1-J13165, ALCOLAC, and Université Nice Sophia Antipolis (1965 - 2019) (UNS)
- Subjects
Computer science ,TAUX D'ALCOOLEMIE ,INTELLIGENCE ARTIFICIELLE ,Cardiac activity ,PHYSIOLOGICAL DATA ,Machine learning ,computer.software_genre ,Cross-validation ,BLOOD ALCOHOL CONCENTRATION ,03 medical and health sciences ,0302 clinical medicine ,0502 economics and business ,Blood alcohol ,CONDUITE DU VEHICULE ,030212 general & internal medicine ,050210 logistics & transportation ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,FUNCTIONAL STATES ,business.industry ,05 social sciences ,Lateral positioning ,ATTENTION ,NOUVEAU CONDUCTEUR ,COMPORTEMENT DU CONDUCTEUR ,State (functional analysis) ,PERFORMANCE ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,Random forest ,Alertness ,PHYSIOLOGIE ,SIMULATEUR DE CONDUITE ,DRIVER ,Artificial intelligence ,MACHINE LEARNING ,business ,Alcohol consumption ,computer - Abstract
BIBM 2018, IEEE International Conference on Bioinformatics and Biomedicine, Madrid, ESPAGNE, 03-/12/2018 - 06/12/2018; Machine learning (ML) technics have been recently used to detect emotion and predict crash severity. This research work aims at assessing different classifications and machine learning technics in predicting the alcohol consumption and associated functional states. 28 young drivers were tested for a 45 min drive with a blood alcohol concentration (BAC) of 0.0, 0.2 and 0.5g/m. Subjective functional states were analysed using Thayer's scale and NASA-TLX. The physiological parameters (electroencephalogram, electrodermal and cardiac activity) and driver simulators parameters (speed, lateral positioning and wheel steering) were acquired during the three alcohol sessions. Data were analysed on 10s temporal windows without superposition nor gap. Two analyses using classification and ML technics were used: to determine both capacity of the algorithms to detect alcohol consumption (BAC level) and functional states (effort, performance and alertness) from NASA and Thayer's scales. Different algorithms were trained using 10 folds cross validation technics using Weka (University of Waikato, NZ). Using both vehicle and physiological data was beneficial for BAC prediction and ROC area of the top three algorithms were found between 0.62 and 0.72 with higher results for Random Forest (RF) algorithms. In functional states prediction, results were similar for all effort, performance and alertness predictions with ROC area reaching 0.75 for RF. Once algorithm setting optimized, performances for BAC prediction reached 0.73 while were, lower than for functional states prediction with ROC area of 0.91 when pairing data. Such results could help in the strategy for detecting alcohol consumption in drivers.
- Published
- 2018
36. Are the Current Doppler Echocardiography Criteria Able to Discriminate Mitral Bileaflet Mechanical Heart Valve Malfunction? An In Vitro Study
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Philippe Pibarot, Lyes Kadem, Morgane Evin, Carine Guivier-Curien, and Régis Rieu
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,0206 medical engineering ,Biomedical Engineering ,Mean pressure ,Medicine (miscellaneous) ,Bioengineering ,02 engineering and technology ,030204 cardiovascular system & hematology ,Doppler echocardiography ,Prosthesis ,Mechanical heart-valve ,Biomaterials ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Internal medicine ,medicine ,In vitro study ,Pressure gradient ,medicine.diagnostic_test ,business.industry ,General Medicine ,Stroke volume ,020601 biomedical engineering ,cardiovascular system ,symbols ,Cardiology ,business ,Doppler effect - Abstract
Malfunction of bileaflet mechanical heart valves in the mitral position could either be due to patient-prosthesis mismatch (PPM) or leaflet obstruction. The aim of this article is to investigate the validity of current echocardiographic criteria used for diagnosis of mitral prosthesis malfunction, namely maximum velocity, mean transvalvular pressure gradient, effective orifice area, and Doppler velocity index. In vitro testing was performed on a double activation left heart duplicator. Both PPM and leaflet obstruction were investigated on a St. Jude Medical Master. PPM was studied by varying the St. Jude prosthesis size (21, 25, and 29 mm) and stroke volume (70 and 90 mL). Prosthesis leaflet obstruction was studied by partially or totally blocking the movement of one valve leaflet. Mitral flow conditions were altered in terms of E/A ratios (0.5, 1.0, and 1.5) to simulate physiologic panel of diastolic function. Maximum velocity, effective orifice area, and Doppler velocity index are shown to be insufficient to distinguish normal from malfunctioning St. Jude prostheses. Doppler velocity index and effective orifice area were 1.3 ± 0.49 and 1.83 ± 0.43 cm(2) for testing conditions with no malfunction below the 2.2 and 2 cm(2) thresholds (1.19 cm(2) for severe PPM and 1.23 cm(2) for fully blocked leaflet). The mean pressure gradient reached 5 mm Hg thresholds for several conditions of severe PPM only (6.9 mm Hg and mean maximum velocity value: 183.4 cm/s) whereas such value was never attained in the case of leaflet obstruction. In the case of leaflet obstruction, the maximum velocity averaged over the nine pulsed-wave Doppler locations increased by 38% for partial leaflet obstruction and 75% for a fully blocked leaflet when compared with normal conditions. Current echocardiographic criteria might be suboptimal for the detection of bileaflet mechanical heart valve malfunction. Further developments and investigations are required in order to further improve current guidelines.
- Published
- 2016
37. Scan-rescan reproducibility of ventricular and atrial MRI feature tracking strain
- Author
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Adrian Thomas Huber, Benoit Diebold, Morgane Evin, Nadjia Kachenoura, Gilles Soulat, Alban Redheuil, Elie Mousseaux, Alain Giron, Jerome Lamy, Alain De Cesare, Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de radiologie cardio-vasculaire [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Service de radiologie cardiovasculaire et interventionnelle [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], and Service d'imagerie cardiovasculaire et de radiologie interventionnelle [CHU Pitié-Salpêtrière]
- Subjects
Male ,Heart Ventricles ,Heart chamber ,Left atrium ,Magnetic Resonance Imaging, Cine ,MAGNETIC RESONANCE IMAGING ,Health Informatics ,030204 cardiovascular system & hematology ,COEUR ,030218 nuclear medicine & medical imaging ,MEDECINE ,03 medical and health sciences ,0302 clinical medicine ,EVALUATION ,DEFORMATION ,REPRODUCIBILITY ,medicine ,Image Processing, Computer-Assisted ,Humans ,Heart Atria ,CINETIQUE ,Aged ,Reproducibility ,medicine.diagnostic_test ,Strain (chemistry) ,REPRODUCTIBILITE ,business.industry ,HEART CHAMBERS ,Reproducibility of Results ,Magnetic resonance imaging ,Middle Aged ,FEATURE TRACKING ,Computer Science Applications ,MYOCARDIAL STRAIN ,medicine.anatomical_structure ,Fractional area change ,Radial motion ,Feature tracking ,Female ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,ETUDE CLINIQUE ,Nuclear medicine ,business ,Algorithms ,IMAGERIE A RESONNANCE MAGNETIQUE - Abstract
Background A feature tracking (FT) was designed to simultaneously extract myocardial strains in main cardiac chambers from cine MRI images. Its inter-observer and scan-rescan reproducibility was assessed and sample sizes required to detect predefined longitudinal changes in strain values were provided. Method FT was applied on left (LV) and right (RV) ventricles as well as left atrium (LA) of 21 individuals (66 ± 10 years) who underwent 2 MRIs 2 weeks apart. Global peaks for radial, circumferential, longitudinal strains, radial motion fraction (Mr), fractional area change (FAC) and tricuspid annular plane excursion (TAPSE) were estimated. Inter-operator and inter-exam reproducibility were evaluated using coefficients of variations (CV) and intra-class correlation coefficients (ICC). Results Reproducibility of all measurements were good to excellent for inter-operator (LV:CV 0.91; RV:CV 0.86; LA:CV 0.85) and inter-study (LV:CV 0.65; RV:CV 0.71; LA:CV 0.83) evaluations. Reasonable sample sizes are required to detect a longitudinal difference of 10–15% in strain values (LV:5 to 33 individuals, RV:14 to 62 individuals, LA:4 to 65 individuals). Conclusions FT-based functional evaluation of main heart chamber deformation from cine MRI is repeatable and thus suitable for follow-up. Strain measurements may help for the joint clinical evaluation of LV, RV or LA implication in various cardiomyopathies.
- Published
- 2018
38. Cardiac MR Strain: A Noninvasive Biomarker of Fibrofatty Remodeling of the Left Atrial Myocardium
- Author
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Myriam Berthet, Adrian Thomas Huber, Nadjia Kachenoura, Philippe Cluzel, Stéphane N. Hatem, Karine Clément, Alban Redheuil, Amer Rahhal, Guillaume Lebreton, Fabrice Atassi, Richard Isnard, Pascal Leprince, Morgane Evin, Jerome Lamy, Carine Defrance, Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Laboratoire d'Imagerie Biomédicale (LIB), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Cadic, Ifsttar, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], and Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Aix Marseille Université (AMU)
- Subjects
HEART ATRIA ,Volume overload ,TISSU ,MAGNETIC RESONANCE IMAGING ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,MEDECINE ,0302 clinical medicine ,CINE ,FIBROSIS ,Prospective cohort study ,HOMME ,Aged, 80 and over ,CORPS HUMAIN ,medicine.diagnostic_test ,Atrial fibrillation ,HUMANS ,3. Good health ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,FEMALE ,ADIPOSE TISSUE ,Cardiology ,Biomarker (medicine) ,AGED ,IMAGERIE A RESONNANCE MAGNETIQUE ,medicine.medical_specialty ,MITRAL VALVE INSUFFICIENCY ,Magnetic Resonance Imaging, Cine ,80 AND OVER ,ATRIAL REMODELING ,COEUR ,03 medical and health sciences ,ADULT ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,ADULTE ,Mitral regurgitation ,Receiver operating characteristic ,CASE-CONTROL STUDIES ,MALE ,business.industry ,Case-control study ,Magnetic resonance imaging ,PROSPECTIVE STUDIES ,medicine.disease ,MIDDLE AGED ,PHYSIOLOGIE ,FEMME ,CHIRURGIE ,business ,ETUDE - Abstract
Purpose To determine whether left atrial (LA) strain quantification with cardiac magnetic resonance (MR) imaging feature tracking is associated with the severity of LA fibrofatty myocardial remodeling at histologic analysis. Materials and Methods This prospective case-control study was approved by the institutional review board. LA strain was evaluated with cardiac MR feature tracking between January 2014 and March 2015 in 13 consecutive patients (mean age, 61 years ± 19; nine male) with mitral regurgitation in the 24 hours before mitral valve surgery and 13 age- and sex-matched healthy control subjects. LA strain parameters were compared first between control subjects and patients and then according to atrial fibrillation and mitral regurgitation status. Associations between LA strain and histology of preoperative biopsies were reported by using receiver operating characteristic curve analysis and Spearman correlation. Results Peak longitudinal atrial strain (PLAS) was significantly lower in patients with mitral regurgitation than in healthy control subjects (P < .001). Increased LA remodeling was significantly related to altered LA strain, and the strongest association was found between PLAS and the degree of fibrofatty myocardial replacement at histologic analysis (r = -0.75, P = .017). LA end-diastolic volume was increased in patients with mitral regurgitation when compared with that in healthy volunteers (P < .001) because of volume overload; however, volume did not correlate with the histologic degree of LA fibrofatty replacement (r = -0.35, P = .330). Conclusion LA strain, especially PLAS, correlates strongly with the degree of fibrofatty replacement at histologic analysis. Such functional imaging biomarker in combination with LA volumetry could help to guide clinical decisions, since myocardial structural remodeling is a known morphologic substrate of LA dysfunction leading to atrial fibrillation with adverse outcome. © RSNA, 2017 Online supplemental material is available for this article.
- Published
- 2018
39. Assessment of left atrial function by MRI myocardial feature tracking
- Author
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Philippe Cluzel, Jerome Lamy, Slawek Kusmia, Carine Defrance, Nadjia Kachenoura, Stéphane N. Hatem, Elie Mousseaux, Gilles Soulat, Morgane Evin, Charles Roux, David Rosenbaum, Karine Clément, and Alban Redheuil
- Subjects
Reproducibility ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Myocardial feature ,Magnetic resonance imaging ,030204 cardiovascular system & hematology ,medicine.disease ,Imaging phantom ,030218 nuclear medicine & medical imaging ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Aortic valve area ,Left atrial ,Aortic valve stenosis ,medicine ,Feature tracking ,Radiology, Nuclear Medicine and imaging ,Nuclear medicine ,business - Abstract
Background Left atrium (LA) volumes and function are predictors of cardiovascular events. Because LA function cannot be assessed from cardiovascular magnetic resonance imaging (MRI) using the well-established left ventricular tagging techniques, we hypothesized that adequate feature tracking (FT) applied to conventional cine MRI data could characterize LA function accurately. Methods We studied 10 young (28 ± 7 years) and 10 elderly (64 ± 6 years) healthy subjects, as well as 20 patients with moderate to severe aortic valve stenosis (AVS; 73 ± 15 years, effective aortic valve area: 0.67 ± 0.36 cm2). MRI cine two-, three-, and four-chamber views were analyzed using a newly proposed FT method based on spatial correlation and endocardial detection resulting in: regional and global longitudinal strain and strain rate, radial motion fraction and relative velocity for the three LA motion phases including reservoir, conduit, and LA contraction. Results FT reliability was indicated by a good overlap between tracking results and manual LA endocardial borders, the low error for comparison against theoretical strains introduced in a synthetic phantom and the good inter-observer reproducibility (coefficient of variation
- Published
- 2015
40. The Differential Meaning of LV and LA Strains in Aortic Valve Stenosis: A Feature Tracking MRI Study
- Author
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Gilles Soulat, Elie Mousseaux, Jerome Lamy, Khaoula Bouazizi-Verdier, Alain Giron, Alban Redheuil, Morgane Evin, Nadjia Kachenoura, Laboratoire d'Imagerie Biomédicale [Paris] (LIB), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
medicine.medical_specialty ,Contraction (grammar) ,Ejection fraction ,Strain (chemistry) ,Longitudinal strain ,business.industry ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,[SPI]Engineering Sciences [physics] ,0302 clinical medicine ,Internal medicine ,Aortic valve stenosis ,cardiovascular system ,medicine ,Cardiology ,Feature tracking ,business ,Radial stress - Abstract
Feature tracking (FT) is an emerging approach for the evaluation of both left atrium (LA) and left ventricular (LV) myocardial strain from cine MRI. We aimed to: 1) perform a simultaneous evaluation of LA and LV strain in patients with aortic valve stenosis (A VS) and 2) evaluate associations of LA strain measurements with LV remodeling (LVmass/LVend-diastolic volume) and strain. We studied 55 patients (34 AVS:71±11 years, 21 controls :66±9 years) with preserved LV ejection fraction (LVEF). FT was applied to cine MRI to extract LV longitudinal, circumferential and radial strain as well as LA longitudinal strain and radial motion fraction for the reservoir, conduit and LA contraction phases. All LV strains decreased significantly in AVS. Similarly, all LA indices showed a decreasing trend in AVS patients as compared to controls. While reservoir and conduit phases LA strains were significantly associated with LV remodeling and strain (r>0.42), lower correlations were found for comparisons with LA contraction phase strains (r
- Published
- 2017
41. Finite element model of a below-knee amputation: a feasibility study
- Author
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D Campion, Maxime Llari, Laurent Thefenne, Morgane Evin, Fuhao Mo, Nawfal Dakhil, Michel Behr, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Hunan University [Changsha] (HNU), Hôpital d'Instruction des Armées Laveran, and Service de Santé des Armées
- Subjects
030506 rehabilitation ,MALADIE ,SOCKET PRESSURES ,Biomedical Engineering ,Bioengineering ,MEDECINE ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,DIABETE ,Below knee amputation ,GENOU ,OPTIMIZATION ,ANALYSE NUMERIQUE ,Orthodontics ,PROTHESE ,CORPS HUMAIN ,Lower limb prosthesis ,LOWER LIMB PROSTHESIS ,business.industry ,OPTIMISATION ,General Medicine ,Trans tibial amputation ,Finite element method ,3. Good health ,Computer Science Applications ,Human-Computer Interaction ,SIMULATION NUMERIQUE ,FINITE ELEMENT MODEL ,METHODE DES ELEMENTS FINIS ,CHIRURGIE ,MEMBRE INFERIEUR ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,0305 other medical science ,business ,030217 neurology & neurosurgery ,TRANS-TIBIAL AMPUTATION ,TRAUMATISME - Abstract
In 2005, the number of lower limb amputees was 1.6 million in the USA and is projected to reach 3.6 in 2050. Among causes for amputations, dysvascular diseases, trauma and diabetes are the main one and dysvascular conditions are increasing because of an ageing population [1]. The manufacturing of lower limb prosthesis is currently mainly artisanal while the use of computer assistance is still limited. As a consequence, the quality of the prosthesis will greatly depend on the prosthetist know-how. However, this is not the only factor influencing prosthesis quality, and the type of the prosthesis, its design, or the materials for both liner and socket should also be taken into account. Although prosthesis quality assessment is subjective, quantitative measurements such as pressures or temperatures in the liner and patient feedback through questionnaires can be assessed. Mechanical interactions between a stump and the prosthesis were accurately predicted using finite element method (FEM) [2,3]. Existing models mainly aim to develop a realistic model with no or limited validation. Complete optimization of the prosthesis using numerical analysis has, to the best of our knowledge, not been fully performed. Thus, the main objective of this project is to define a new FEM method to fully optimize prosthesis shape in order to improve the subject's comfort. The definition of this method will first need a validation of the FEM by comparing experiments and simulations results together with measuring the method reproducibility.
- Published
- 2017
42. Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis
- Author
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Rachel T. McGrath, Rebecca Kozor, Nadjia Kachenoura, Kathryn M. Broadhouse, Fraser M. Callaghan, Samantha L. Hocking, Sarah J. Glastras, Gemma A. Figtree, Morgane Evin, Jerome Lamy, Stuart M. Grieve, Greg Fulcher, Alban Redheuil, Laboratoire d'Imagerie Biomédicale (LIB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Royal North Shore Hospital (RNSH), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), and BMC, BMC
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Male ,Obesity and type 2 ,Endocrinology, Diabetes and Metabolism ,[SDV]Life Sciences [q-bio] ,Adipose tissue ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Diastole ,Risk Factors ,Original Investigation ,Adiposity ,medicine.diagnostic_test ,Middle Aged ,3. Good health ,[SDV] Life Sciences [q-bio] ,Adipose Tissue ,Cardiology ,Cardiac dysfunction ,Diastolic dysfunction ,Atrial Function, Left ,Female ,Cardiology and Cardiovascular Medicine ,Pericardium ,Algorithms ,Adult ,medicine.medical_specialty ,Heart Diseases ,Magnetic Resonance Imaging, Cine ,Fat distribution ,03 medical and health sciences ,Predictive Value of Tests ,Internal medicine ,Diabetes mellitus ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Obesity ,Angiology ,business.industry ,Case-control study ,Magnetic resonance studies ,Magnetic resonance imaging ,medicine.disease ,Early Diagnosis ,Diabetes Mellitus, Type 2 ,Case-Control Studies ,business - Abstract
Background Diastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability of magnetic resonance imaging (MRI) derived left atrial (LA) strain to detect early diastolic dysfunction in individuals with obesity and type 2 diabetes, and to explore the association between cardiac adipose tissue and LA function. Methods Twenty patients with obesity and T2D (55 ± 8 years) and nineteen healthy controls (48 ± 13 years) were imaged using cine steady state free precession and 2-point Dixon cardiovascular magnetic resonance. LA function was quantified using a feature tracking technique with definition of phasic longitudinal strain and strain rates, as well as radial motion fraction and radial velocities. Results Systolic left ventricular size and function were similar between the obesity and type 2 diabetes and control groups by MRI. All patients except four had normal diastolic assessment by echocardiography. In contrast, measures of LA function using magnetic resonance feature tracking were uniformly altered in the obesity and type 2 diabetes group only. Although there was no significant difference in intra-myocardial fat fraction, Dixon 3D epicardial fat volume(EFV) was significantly elevated in the obesity and type 2 diabetes versus control group (135 ± 31 vs. 90 ± 30 mL/m2, p Conclusions LA MRI-strain may be a sensitive tool for the detection of early diastolic dysfunction in individuals with obesity and type 2 diabetes and correlated with BMI and epicardial fat supporting a possible association between adiposity and LA strain. Trials Registration Australian New Zealand Clinical Trials Registry No. ACTRN12613001069741
- Published
- 2016
43. Effect of oversizing and elliptical shape of aortic annulus on transcatheter valve hemodynamics: An in vitro study
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Régis Rieu, Frederic Collart, Morgane Evin, Erwan Salaun, Anne-Sophie Zenses, Gilbert Habib, Philippe Pibarot, CHU Pontchaillou [Rennes], Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de cardiologie de Québec, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Aortic Valve Insufficiency ,Mean pressure ,Hemodynamics ,030204 cardiovascular system & hematology ,Performance index ,Transcatheter Aortic Valve Replacement ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,In vitro study ,Humans ,030212 general & internal medicine ,Cardiac skeleton ,Heart valve ,business.industry ,Effective orifice area ,Stroke volume ,Echocardiography, Doppler ,medicine.anatomical_structure ,Heart Valve Prosthesis ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
International audience; Background: Transcatheter aortic valve implantation (TAVI) is often performed in patients with non-circular aortic annulus and in oversizing (OS) conditions. The impact of elliptical annulus shape and the consequences of oversizing/underdeployment on the hemodynamic performance are still debated. Objective: This in-vitro study aims to assess and compare the valve hemodynamic performances of the Edwards SAPIEN transcatheter heart valve (THV) in the different current conditions of use: important oversizing in small circular annuli and in elliptical annuli, moderate oversizing in circular and in elliptical annuli of various degrees of eccentricity. Methods: A pulsed cardiovascular simulator was used. Edwards SAPIEN 23 and 26 (mm) were implanted in different circular and elliptical annuli of various sizes and eccentricity. Transvalvular mean pressure gradients (TPGm), effective orifice area (EOA) after implantation of Edwards SAPIEN THV were measured by Dopplere-chocardiography and the performance index (PI - 100 x EOA / Annulus Area) was calculated. Para and transvalvular regurgitation was assessed by color-Doppler and leakage volume was quantified by flowmeter measurement. Results: For a given aortic annulus area, EOAs after implantation of Edwards SAPIEN THV were generally larger and TPGms lower with elliptical annuli compared to circular annuli. The PI was higher (p = 0.047) for elliptical (48 +/- 3%) than for circular annuli (43 +/- 5%). Paravalvular regurgitation occurred only in the case of the SAPIEN 26 implanted in the elliptical annulus with highest eccentricity. Conclusion: The results of this in-vitro study suggest that the EOAs of Edwards SAPIEN are better in elliptical than in circular annuli. No transvalvular regurgitation occurred and only one paravalvular regurgitation was observed after implantation of SAPIEN 26 in the highly eccentric annulus. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2016
44. Mitral valve-in-valve hemodynamic performance: An in vitro study
- Author
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Josep Rodés-Cabau, Morgane Evin, Carine Guivier-Curien, Philippe Pibarot, Régis Rieu, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval [Québec] (ULaval), Institut de cardiologie de Québec, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Pulmonary and Respiratory Medicine ,Models, Anatomic ,medicine.medical_specialty ,Cardiac Catheterization ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Hemodynamics ,Regurgitation (circulation) ,030204 cardiovascular system & hematology ,Prosthesis Design ,03 medical and health sciences ,0302 clinical medicine ,Mitral valve stenosis ,Internal medicine ,Mitral valve ,Materials Testing ,medicine ,Humans ,Mitral Valve Stenosis ,Cardiac catheterization ,Bioprosthesis ,Heart Valve Prosthesis Implantation ,business.industry ,Effective orifice area ,Models, Cardiovascular ,Mitral Valve Insufficiency ,medicine.disease ,Surgery ,Prosthesis Failure ,Stenosis ,medicine.anatomical_structure ,030228 respiratory system ,Heart Valve Prosthesis ,Regurgitant fraction ,Cardiology ,Mitral Valve ,Cardiology and Cardiovascular Medicine ,business - Abstract
International audience; Objectives: The valve-in-valve (VinV) procedure may be used in high-risk patients with failed mitral surgical bioprostheses. The objective of this in vitro study was to assess the hemodynamic function of different VinV configurations. Methods: A double activation duplicator was used to test 11 valve configurations (surgical bioprostheses alone) and 15 VinV configurations (Sapien [Edwards Lifesciences, Irvine, Calif] implanted within the surgical bioprosthesis) under 8 different hemodynamic conditions. The internal orifice diameter (IOD) of the surgical bioprosthesis was measured with a Smartscope (OGP Multi Sensor Measuring Instruments, Singapore). Results: The VinV procedure was associated with significant deterioration in antegrade hemodynamic parameters compared with valve configuration (effective orifice area, 1.51 +/- 0.21 cm 2 vs 1.65 +/- 0.37 cm 2; P 20%, and IOD > 23 mm was associatedwith higher risk of paravalvular regurgitation when oversizing was 20%. Significant paravalvular regurgitation is rare and occurs with larger IODs and lower percentage of oversizing (8%).
- Published
- 2016
45. Are the Current Doppler Echocardiography Criteria Able to Discriminate Mitral Bileaflet Mechanical Heart Valve Malfunction? An In Vitro Study
- Author
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Morgane, Evin, Carine, Guivier-Curien, Philippe, Pibarot, Lyes, Kadem, and Régis, Rieu
- Subjects
Heart Valve Prosthesis ,Hemodynamics ,Humans ,Mitral Valve ,Prosthesis Design ,Echocardiography, Doppler ,Prosthesis Failure - Abstract
Malfunction of bileaflet mechanical heart valves in the mitral position could either be due to patient-prosthesis mismatch (PPM) or leaflet obstruction. The aim of this article is to investigate the validity of current echocardiographic criteria used for diagnosis of mitral prosthesis malfunction, namely maximum velocity, mean transvalvular pressure gradient, effective orifice area, and Doppler velocity index. In vitro testing was performed on a double activation left heart duplicator. Both PPM and leaflet obstruction were investigated on a St. Jude Medical Master. PPM was studied by varying the St. Jude prosthesis size (21, 25, and 29 mm) and stroke volume (70 and 90 mL). Prosthesis leaflet obstruction was studied by partially or totally blocking the movement of one valve leaflet. Mitral flow conditions were altered in terms of E/A ratios (0.5, 1.0, and 1.5) to simulate physiologic panel of diastolic function. Maximum velocity, effective orifice area, and Doppler velocity index are shown to be insufficient to distinguish normal from malfunctioning St. Jude prostheses. Doppler velocity index and effective orifice area were 1.3 ± 0.49 and 1.83 ± 0.43 cm(2) for testing conditions with no malfunction below the 2.2 and 2 cm(2) thresholds (1.19 cm(2) for severe PPM and 1.23 cm(2) for fully blocked leaflet). The mean pressure gradient reached 5 mm Hg thresholds for several conditions of severe PPM only (6.9 mm Hg and mean maximum velocity value: 183.4 cm/s) whereas such value was never attained in the case of leaflet obstruction. In the case of leaflet obstruction, the maximum velocity averaged over the nine pulsed-wave Doppler locations increased by 38% for partial leaflet obstruction and 75% for a fully blocked leaflet when compared with normal conditions. Current echocardiographic criteria might be suboptimal for the detection of bileaflet mechanical heart valve malfunction. Further developments and investigations are required in order to further improve current guidelines.
- Published
- 2016
46. Left atrial aging: a cardiac magnetic resonance feature-tracking study
- Author
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Nadjia Kachenoura, Stéphane N. Hatem, Alban Redheuil, Golmehr Ashrafpoor, Jerome Lamy, Gilles Soulat, Charles Roux, Carine Defrance, Elie Mousseaux, Alain Giron, Ludivine Perdrix, Benoit Diebold, Morgane Evin, Laboratoire d'Imagerie Biomédicale (LIB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Radiologie Vasculaire [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Institut de cardiologie [CHU Pitié-Salpêtrière], Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de Cardiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), HAL-UPMC, Gestionnaire, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Génétique, pharmacologie et physiopathologie des maladies cardiovasculaires [Paris], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire d'Imagerie Biomédicale ( LIB ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition ( ICAN ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Paris-Centre de Recherche Cardiovasculaire, Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
Male ,Time Factors ,Longitudinal strain ,Physiology ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Normal aging ,030204 cardiovascular system & hematology ,Doppler echocardiography ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Left atrial ,magnetic resonance imaging ,feature tracking ,ComputingMilieux_MISCELLANEOUS ,[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging ,medicine.diagnostic_test ,Age Factors ,Middle Aged ,[ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Echocardiography, Doppler ,Healthy Volunteers ,Biomechanical Phenomena ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Cardiology ,cardiovascular system ,Atrial Function, Left ,Female ,left atrial function ,Cardiology and Cardiovascular Medicine ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Adult ,medicine.medical_specialty ,Magnetic Resonance Imaging, Cine ,Young Adult ,03 medical and health sciences ,Sex Factors ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Heart Atria ,business.industry ,aging ,Magnetic resonance imaging ,Strain rate ,Myocardial Contraction ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,Feature tracking ,Stress, Mechanical ,Cardiac magnetic resonance ,business - Abstract
Importance of left atrial (LA) phasic function evaluation is increasingly recognized for its incremental value in terms of prognosis and risk stratification. LA phasic deformation in the pathway of normal aging has been characterized using echocardiographic speckle tracking. However, no data are available regarding age-related variations using feature-racking (FT) techniques from standard cine magnetic resonance imaging (MRI). We studied 94 healthy adults (41 ± 14 yr, 47 women), who underwent MRI and Doppler echocardiography on the same day for left ventricular (LV) diastolic function evaluation. From cine MRI, longitudinal strain and strain rate, radial motion fraction, and radial relative velocity, respectively, corresponding to the reservoir, conduit, and LA contraction phases, were measured using dedicated FT software. Longitudinal strain and radial motion fraction decreased gradually and significantly with aging for both reservoir ( r > 0.31, P < 0.003) and conduit ( r > 0.54, P < 0.001) phases, whereas they remained unchanged during the LA contraction phase. Subsequently, the LA contraction-to-reservoir ratio increased significantly with age ( r > 0.44, P < 0.001). Longitudinal strain rate and radial relative velocity significantly decreased with age (reservoir: r = 0.39, P < 0.001, conduit: r > 0.54, P < 0.001), and these associations tended to be stronger in women than in men. Finally, associations of LA functional indexes with age were stronger in individuals with lower transmitral early-to-atrial maximal velocity ratio and mitral annulus maximal longitudinal velocity, as well as higher transmitral early maximal-to-mitral annulus maximal longitudinal velocity ratio, highlighting the LV-LA interplay. Age-related changes in LA phasic function indexes were quantified by cine MRI images using a FT technique and were significantly related to age and LV diastolic function.
- Published
- 2016
47. CMR left atrial characterization in Cushing's syndrome: a feature tracking study
- Author
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Alban Redheuil, P. Cluzel, Peter Kamenicky, Zainab Raissuni, Jerome Lamy, Elie Mousseaux, Nadjia Kachenoura, Roux Charles, Morgane Evin, Laboratoire d'Imagerie Biomédicale (LIB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
medicine.medical_specialty ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Left atrium ,Bioinformatics ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Left atrial ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,ComputingMilieux_MISCELLANEOUS ,Angiology ,Medicine(all) ,Radical treatment ,Lv function ,S syndrome ,Radiological and Ultrasound Technology ,business.industry ,medicine.anatomical_structure ,Poster Presentation ,cardiovascular system ,Cardiology ,Feature tracking ,Cardiology and Cardiovascular Medicine ,business ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing - Abstract
Background The aim of this study was to automatically assess global and regional left atrium (LA) strain in Cushing’s syndrome (CD). Modifications of LA and LV function in patients have been highlighted followed by the restoration of myocardial function after radical treatment and cortisol normalization. Our hypothesis was that a feature-tracking method could improve the understanding of the mechanisms of LA alteration concerning its reservoir, conduit, and atrial contraction phases.
- Published
- 2015
48. Functional left atrial CMR parameters are early predictors of left atrial alterations in hypertension and strongly associated with lv remodeling
- Author
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P. Cluzel, Zainab Raissuni, Morgane Evin, Alban Redheuil, Elie Mousseaux, and Nadjia Kachenoura
- Subjects
Medicine(all) ,medicine.medical_specialty ,Functional evaluation ,Contraction (grammar) ,Radiological and Ultrasound Technology ,business.industry ,Left atrial ,Internal medicine ,Poster Presentation ,cardiovascular system ,Cardiology ,Medicine ,Feature tracking ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Heart failure with preserved ejection fraction ,Angiology - Abstract
Background Left atrial (LA) structural and functional changes are determinant steps on the pathway toward heart failure with preserved ejection fraction in hypertensive (HT) patients. Most LA studies are based on LA volumes evaluation in CMR and echocardiography or on echocardiographic speckle tracking estimation. Since LA functional evaluation by CMR is now emerging we aimed at 1) evaluating LA function by CMR in controls and hypertensive patients (moderate and severe HT) using feature tracking technique on conventional cine data; 2) evaluating the relationship between the components of LA function (reservoir, conduit, atrial contraction) and left ventricular (LV) remodeling.
- Published
- 2015
49. Mitral bileaflet mechanical heart valves dysfunction and patient/prosthesis mismatch:in vitroinvestigation of differential diagnosis
- Author
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Morgane Evin, Anne-Sophie Zenses, Régis Rieu, Carine Guivier-Curien, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), PROTOMED, and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Biomedical Engineering ,Hemodynamics ,Bioengineering ,030204 cardiovascular system & hematology ,Doppler echocardiography ,01 natural sciences ,Prosthesis ,010305 fluids & plasmas ,Diagnosis, Differential ,Mechanical heart ,valve dysfunction ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Prosthesis Fitting ,Internal medicine ,0103 physical sciences ,medicine ,Humans ,[PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] ,Cardiac Output ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,ComputingMilieux_MISCELLANEOUS ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Models, Cardiovascular ,mitral bileaflet mechanical heart valve ,Mitral Valve Insufficiency ,[PHYS.MECA]Physics [physics]/Mechanics [physics] ,General Medicine ,3. Good health ,Computer Science Applications ,Equipment Failure Analysis ,Human-Computer Interaction ,Heart Valve Prosthesis ,patient prosthesis mismatch ,Cardiology ,Mitral Valve ,localised pressure gradient ,Differential diagnosis ,business ,Blood Flow Velocity ,Body orifice - Abstract
For bileaflet mechanical heart valves, the orifice available for the flow to go through is divided into three, which influences haemodynamic characteristics obtained by Doppler echocardiography [ef...
- Published
- 2013
50. EFFECT OF VALVE OVERSIZING ON LEAFLET BENDING STRESS IN THE COREVALVE: AN IN VITRO STUDY
- Author
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Lionel Thollon, Viktória Stanová, Régis Rieu, Philippe Pibarot, Anne-Sophie Zenses, Morgane Evin, Lyes Kadem, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Department of Mechanical and Industrial Engineering, Concordia University [Montreal], Institut de cardiologie de Québec, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
medicine.medical_specialty ,Leaflet (botany) ,business.industry ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,medicine.disease ,[SPI]Engineering Sciences [physics] ,03 medical and health sciences ,Stenosis ,0302 clinical medicine ,Valve replacement ,Internal medicine ,medicine ,Cardiology ,In vitro study ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,Intermediate risk ,business - Abstract
Background: Transcatheter valve replacement has emerged as a viable alternative in high and intermediate risk patients with severe aortic stenosis. However, the durability of transcatheter valves remains currently largely unknown. Moderate valve oversizing (OS)(5–20% in area) is recommended to
- Published
- 2017
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