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The article delves into Augustin Filon's perspective on John Morley's studies of French Enlightenment figures, emphasizing Morley's impact on modern liberalism. Topics include Morley's views on Voltaire's impact, his interpretation of Rousseau's life, and his analysis of De Maistre's influence on political and religious thought.

This article argues that an analysis of the historical and architectural significance of India House, the London headquarters of the East India Company, can yield new insights into histories of office design and employee management. Utilising company documents, including floor plans, letters, diaries, committee minutes, and a handful of published accounts, it juxtaposes the distinct careers of two employees: the essayist and poet Charles Lamb, who toiled in the Accountant's Office, and the philosopher John Stuart Mill, who worked in the Office of the Examiner of Indian Correspondence. In so doing, it shows how India House between 1800 and 1857 occupied a crucial transitional stage in the history of office design; relates the spatial configurations of these two offices to different governing rationalities of the workplace; and offers a visual semblance of areas of the East India Company's headquarters that were vital to its operations but have gone largely undocumented. [ABSTRACT FROM AUTHOR]

The article looks at the unpublished poem "Ode to Contemplation" by John Wilson Croker, author, literary critic and first secretary of the Admirality in the early 19th century Britain. Topics discussed include the reputation of Crocker as a literary critic in light of his review of the poem "Endymion" by John Keats and works by Mary Shelley and Alfred Tennyson, overview of Croker's poem "The Battles of Talavera," and the absence of punctuation in the "Ode to Contemplation."

A literary criticism of the book "Zami: A New Spelling of My Name" by U.S. poet Audre Lorde is presented. This criticism focuses on the book's representation of the theory of the Oedipus complex created by psychologist Sigmund Freud, particularly girls' intense attachment to their mother in the preoedipal stage. The groundwork for feminist theorizations of the preoedipal state laid by Freud is discussed, as well psychoanalytic accounts of identity formation in the opposite-sex desire on women.

The article discusses the issues on the date, location and circumstance of composition of the poem "Worldly Place" by Matthew Arnold. Also cited are the sonnet's focus on the Roman emperor and Stoic philosopher Marcus Aurelius, the speculations by William Harbutt Dawson and Kenneth Allott on the poem's date and location, as well as Arnold's book "Culture and Anarchy."

The author suggests that Gabriele Rossetti's political associations and his studies of medieval literature has provided another shaping dimension for one of Christina Rossetti's most well-known poems "Winter: My Secret." He notes that the poem is concerned with a speaker who is concealing some bit of knowledge from the reader. The author characterizes the father-daughter relationship between Gabriele and Christina. He argues that the poem betrays a textual ambivalence.

The article offers information related to literary interrelations and work of author Christina Rossetti and modern poet George Herbert. It is noted that Rossetti composed imitations of Herbert's poem "Virtue" and in his book "The Face of the Deep" he makes a direct reference to Herbert's poem "Misery." It is noted that Rossetti derives her understanding of wit by criticizing poetic conventions and comparison of her poetry with Herbert is focused on her devotional works.

The incomplete sonnet titled "Sunset in the San Gabriel Valley" by George Ellery Hale is presented. First Line: Coming in splendor down his path of gold; Last Line: With evening glories far-off peaks of snow.

Building on recent work in book history which shows that analyses of the original periodical context of much nineteenth-century writing can generate variant readings of “official” publications in bound volumes, this essay asks what the transposition of Mary Russell Mitford's understudied character sketches from magazine to various book forms tells us about the modulation of narrative voice in different print venues. In the first section, the author examines these sketches—instead of Mitford's more widely studied pieces on rural scenery—synchronically with surrounding copy in theLady's Magazinein order to show how, in the periodical context, different inflections in Mitford's narrative voice can be discerned from those later marketed in various bound volumes published in the late nineteenth and the twentieth centuries. In the second section, the author provides a genealogy of the popular construction of Mitford as maternal and beneficent, highlighting the role that paratextual framing played in this process. Broadening the paradigmatic “communications circuit”—as Robert Darnton calls the interrelations of a range of actors in book production (from the author to the publisher, printer and distributor)—to include periodicals, the author traces the history of manufacturing “Mary Russell Mitford” as a cultural commodity. [ABSTRACT FROM PUBLISHER]

B Introduction: b Genetic etiologies of pediatric disease represent an increasing proportion of pediatric intensive care unit (PICU) admissions due to more accessible diagnostic and therapeutic techniques. The central hypothesis is that if a PICU patient has ever had WES performed, then they will carry a higher disease burden on admission than other PICU patients. Comparing all admissions for each patient, those with WES performed demonstrated a higher median PRISM III score of 7 (IQR 3, 12) relative to the general PICU population median of 3 (IQR 0, 8) (p < 0.001). [Extracted from the article]

What determines how authoritarian regimes use internationally attained revenues such as natural resource rents to stay in power? The answer, this article argues, lies partly in the nature of the socioeconomic cleavages in the country. The article presents a comparison of Kenya and Mexico, two countries that experienced similar rises and falls in internationally derived nontax revenue in the context of similar political regimes. The countries differed, however, in their socioeconomic cleavages: In Mexico, cleavages were along sectoral or class lines, whereas in Kenya they were along ethnic lines. The author demonstrates how these differences led governments in the countries to use nontax revenues in different ways, with important consequences in particular for social spending. Despite the recent turn in the resource curse literature emphasizing domestic contextual factors, socioeconomic cleavages have been relatively ignored. The findings here begin to fill that gap, with important implications for several literatures. [ABSTRACT FROM PUBLISHER]

The article provides a discussion of the gestural and rhetorical modes of male suffering as suffering while recognizing them as calculated strategies at the same time, as figured by novelists Emily Brontë and George Eliot. It is inferred that they were able to acknowledge the violence that men inflict on women emotionally, and its cause which is outside men's individual control. It is also mentioned that the conclusion of Eliot's novel "The Mill on the Floss" suggests that modern conjugality is based on psychic pain.

Inhibition of central nervous system axon growth is reportedly mediated in part by calcium-dependent phosphorylation of axonal epidermal growth factor receptor, with local administration of the epidermal growth factor receptor kinase inhibitors AG1478 and PD168393 to an optic nerve lesion site promoting adult retinal ganglion cell axon regeneration. Here, we show that epidermal growth factor receptor was neither constitutively expressed, nor activated in optic nerve axons in our non-regenerating and regenerating optic nerve injury models, a finding that is inconsistent with phosphorylated epidermal growth factor receptor-dependent intra-axonal signalling of central nervous system myelin-related axon growth inhibitory ligands. However, epidermal growth factor receptor was localized and activated within most glia in the retina and optic nerve post-injury, and thus an indirect glial-dependent mechanism for stimulated retinal ganglion cell axon growth by epidermal growth factor receptor inhibitors seemed plausible. Using primary retinal cultures with added central nervous system myelin extracts, we confirmed previous reports that AG1478/PD168393 blocks epidermal growth factor receptor activation and promotes disinhibited neurite outgrowth. Paradoxically, neurites did not grow in central nervous system myelin extract-containing cultures after short interfering ribonucleic acid-mediated knockdown of epidermal growth factor receptor. However, addition of AG1478 restored neurite outgrowth to short interfering ribonucleic acid-treated cultures, implying that epidermal growth factor receptor does not mediate AG1478-dependent effects. TrkA-/B-/C-Fc fusion proteins and the kinase blocker K252a abrogated the neuritogenic activity in these cultures, correlating with the presence of the neurotrophins brain derived neurotrophic factor, nerve growth factor and neurotrophin-3 in the supernatant and increased intracellular cyclic adenosine monophosphate activity. Neurotrophins released by AG1478 stimulated disinhibited retinal ganglion cell axon growth in central nervous system myelin-treated cultures by the induction of regulated intramembraneous proteolysis of p75NTR and Rho inactivation. Retinal astrocytes/Müller cells and retinal ganglion cells were the source of neurotrophins, with neurite outgrowth halved in the presence of glial inhibitors. We attribute AG1478-stimulated neuritogenesis to the induced release of neurotrophins together with raised cyclic adenosine monophosphate levels in treated cultures, leading to axon growth and disinhibition by neurotrophin-induced regulated intramembraneous proteolysis of p75NTR. These off-target effects of epidermal growth factor receptor kinase inhibition suggest a novel therapeutic approach for designing treatments to promote central nervous system axon regeneration. [ABSTRACT FROM PUBLISHER]

This essay focuses on the various interpretations of the Alps, a large and scenic mountain system in Europe, in terms of embodiment and modernity by authors including Maurice Merleau-Ponty, John Ruskin and Leslie Stephen. According to Merleau-Ponty, the ability of the body to travel mountainous terrain shapes human freedom. Ruskin believed that sublimity is achievable when one contemplate mountains from afar. Stephen conceived that sublimity is experienced by making physical contact.

This article presents the idea of aesthetic redemption of ordinary experience as evident in the works of cultural critic John Ruskin, writer Marcel Proust, and philosopher Walter Benjamin. The quest for happiness and correspondences with the past is discussed as an objective of all three men. Concepts such as modernity, aesthetic redemption of the present, myth, and remembrance are discussed in the essay.

The deliberative-development approach to policy-making has gained popularity in both academic and policy circles. However, insufficient attention has been paid to the requirements necessary for deliberation to have beneficial effects on policy, some of which are detailed in this article, in particular the need for equality among deliberators. The article examines Bolivia's 2000 National Dialogue and demonstrates the effects of inequality — not between elites and non-elites, but between groups within civil society — on the legitimacy of the outcome. Its findings have important implications for the design of deliberative-development institutions. [ABSTRACT FROM AUTHOR]

Background: In Canada and the United States, the relevance and utility of training objectives as perceived by practising surgeons is rarely examined. We sought to determine if urology residency training objectives reflect the broad realities of urologic practice. Methods: A survey, based on the Royal College of Physicians and Surgeons of Canada training objectives for urology, was designed and validated. All 418 full-time practising members of the Canadian Urological Association were surveyed. Results: The overall response rate was 63%. Many specialized clinical areas of urology that receive little emphasis in the training objectives were rated as useful by the majority: laparoscopic surgery (92%), percutaneous renal access (86%), transrectal ultrasonography (84%), pediatric urology (81%), extracorporeal shockwave lithotripsy (70%), urethral reconstruction (66%) and adrenal surgery (62%). Microsurgery and transplantation were perceived as less useful (54% and 22% respectively). Virtually all nonsurgical training objectives were regarded as useful components of training; however, in the opinion of the majority of respondents residency did not prepare them for many of these: the challenges of office and hospital administration (91% and 89% not prepared [NP]), building a referral base (67% NP), time management (60% NP) and providing care under financial constraints (60% NP). Conclusion: The study results support the current training objectives and indicate areas requiring increased emphasis. [ABSTRACT FROM AUTHOR]

Presents a study that demonstrated elevated expression of the chromosome 11p15.5 insulin-like growth factor 2 gene in congenital fibrosarcoma and cellular mesoblastic nephroma tumors. Importance of an intact insulin-like growth factor (IGF1) 2 gene signaling axis of in vitro ETV6-NTRK3 mediated transformation; Components of IGFRI substrate; Association of insulin-receptor substrate-1 with Grb2.

San Antonio Water System (SAWS) developed its Aquifer Storage Recovery (ASR) program in the Carrizo aquifer to provide potable water supply reliability for San Antonio during droughts while protecting natural ecosystems and threatened and endangered species at Comal Springs and San Marcos Springs and augmenting downstream flows in the San Antonio River and estuarine ecosystems. It enables SAWS to completely optimize use of its Edwards Aquifer Withdrawal Permit with no wasted water, leveling out seasonal demand stresses on the Edwards aquifer. The SAWS Carrizo ASR wellfield recovery hydraulic capacity was designed to provide 64 million gallons per day (MGD) (0.24 Mm3/D). However, as built, the briefly tested recovery capacity, in practice, is approximately 80 MGD (Kirk Nixon and Kevin Morrison, verbal communication, 2022). Almost 200,000 acre feet (AF) (247 Mm3) of drinking water have been stored to date. The water recovered from storage requires only re‐disinfection prior to transmission and distribution to customers. During the period 2011 to 2014, a drought of near record intensity required SAWS to recover a total volume exceeding 50,000 AF (61.7 Mm3) over the 4‐year period. The ASR wellfield area and H2Oaks treatment facility serve as a central location for integration of two other long‐term water supply strategies including desalination of brackish groundwater from the underlying Wilcox aquifer and groundwater production from the local Carrizo aquifer. Several lessons have been learned during 18 years of ASR operation, as addressed in this article. Article impact statement: Lessons learned from 18 years' operating experience at a large ASR wellfield for San Antonio Water System (SAWS), Texas. [ABSTRACT FROM AUTHOR]

The author discusses the application of the English poet Matthew Arnold to become a librarian at the Bodleian Library in Oxford, England. He mentions Arnold's letter to his brother regarding the application, his decision not to apply for the job, and establishes a time frame for the events.

Identifies the core competencies in the study of urology. Identification of the roles that specialist physicians should fulfill to meet the needs of society; Skills that each doctor must have; Issue on the adequacy of postgraduate urological training to meet the requirements of the job.