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1. Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient

Author

Anne E. Mohan, Aaron S. Cote, Eric Khong, Keith A. Mattern, Michael Whittington, Kevin M. Maloney, Eric B. Sirota, Yee Swan Ang, Michael DiBenedetto, Anthony Diaz-Santana, Richard Desmond, Ivan H. Lee, Beata Tao, Muhammad Sofian Bin Asi Sihombing, Christopher Pridgen, Glenn Spencer, Hsieh Yao D. Chang, Kevin M. Sirk, Hong Ren, Si-Wei Zhang, Wenjun Liu, Embarek Alwedi, and Cuixian Yang

Subjects
Active ingredient, Phase map, 010405 organic chemistry, business.industry, Chemistry, Scientific method, Organic Chemistry, Physical and Theoretical Chemistry, 010402 general chemistry, Process engineering, business, 01 natural sciences, 0104 chemical sciences
Abstract

The final chemical transformation and isolation in the synthesis of an active pharmaceutical ingredient (API), referred to as the Pure Step, is often chemically simple but scientifically, operation...

Published
2021
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