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In this article, a novel synthetic route was described for the total synthesis of Sporiolide B from inexpensive and commercially available starting materials by a concise fourteen-step sequence in 6.50% overall yield. This convergent synthesis utilizes Grignard reaction, Asymmetric dihydroxylation, Yamaguchi macrolactonization and ring closing metathesis as the key steps. [ABSTRACT FROM AUTHOR]

A number of 1,3,4-oxadiazole incorporated oxazolo[4,5-b]pyridine derivatives has been synthesized, characterized and tested for anticancer activity against four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205), and ovarian cancer (A2780) using etoposide as a standard drug. All products demonstrate good anticancer activity, several compounds can be considered as promising anticancer agents. [ABSTRACT FROM AUTHOR]