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Gangliosides are complex glycosphingolipids which contain ceramide and various oligosaccharides usually bearing sialic acids. An interesting feature of gangliosides is that their quantitative and qualitative composition changes during oncogenesis. This process is specific and depends on the histological type of a tumor and its functional status even within one neoplasm. On the other hand, latest advances in understanding structural and functional organization of glycosphingolipids, and primarily insights into lipid raft formation, showed that gangliosides may take part in the regulation of the activity of kinases mediating the modulation of signaling pathways involved in the malignant potential of cells. This article describes basic concepts of gangliosides and their biological role in signaling pathways involved in tumor development. We focused on experimental studies revealing both inhibitory and activating effects on important protein receptors responsible for cell proliferation, differentiation and death.

Infantile fibrosarcoma (IFS) is a rare malignant soft tissue tumor characterized by local invasion, a low rate of distant metastasis (1–13%), and manifestation during the first years of life. Overall survival rates range from 89 to 94%, event-free survival rates – from 81 to 84%. Classic IFS is characterized by t(12;15)(p13;q25) translocation resulting in the formation of the ETV6-NTRK3 fusion transcript. However, over the past few years, there have been numerous reports of IFS-like tumors with non-canonical genetic aberrations (BRAF, NTRK1, MET genes) whose prognosis is less predictable. Here we report a rare case of congenital IFS with involvement of subcutaneous fat, indolent course and a non-canonical TPM3-NTRK1 fusion transcript identified in the soft tissue and intradermal tumor components with different histological features. The patient’s parents gave their consent to the use of their child’s data, including photographs, for research purposes and in publications. The literature review explores modern algorithms for the diagnosis and treatment of IFS in children, including the use of new therapies, such as tropomyosin receptor kinase inhibitors, as well as algorithms for detecting NTRK1, NTRK2, NTRK3 gene rearrangements in solid neoplasms in general, and soft tissue tumors in particular.

This article explores both popular and newly invented tools for extracting data from sites and converting them into a form suitable for analysis. The paper compares the Python libraries, the key criterion of the compared tools is their performance. The results will be grouped by sites, tools used and number of iterations, and then presented in graphical form. The scientific novelty of the research lies in the field of application of data extraction tools: we will receive and transform semistructured data from the websites of bookmakers and betting exchanges. The article also describes new tools that are currently not in great demand in the field of parsing and web scraping. As a result of the study, quantitative metrics were obtained for all the tools used and the libraries that were most suitable for the rapid extraction and processing of information in large quantities were selected.

The technology of obtaining coatings consisting of alumina nanoparticles and their agglomerates is presented. The transport properties of coatings and the change of these properties with time are investigated. The dependence of the height of capillary ascent on the quantity of deposited nanofluid on substrates has been established. An estimate of the change in the height of liquid rise and of the permeability of a coating with the change in the size of particles has been made. Deterioration of the transport properties of porous coatings consisting of alumina nanoparticles with time is investigated, and the possibility of restoring these properties is shown.

An Erratum to this paper has been published: https://doi.org/10.3103/S1068371223330015

Langmuir-Blodgett films were obtained on the basis of octadecylamine monolayers containing nanoparticles of various metals hexacyanoferrates. Nanoparticles were prepared using sodium hexametaphosphate as a stabilizer, their average sizes were determined by laser diffraction method. The effect of a stabilizer on the size and shape of hexacyanoferrates particles was shown by scanning electron microscopy, and the morphology of octadecylamine monolayers containing the obtained nanoparticles was studied.

Langmuir-Blodgett films modified by an electrochemically active compound, such as cobalt hexacyanoferrate, are of interest to create water-insoluble film electrodes with a high concentration of active centers and a low response time. The possibility of introducing cobalt hexacyanoferrate nanoparticles stabilized by sodium hexametaphosphate in octadecylamine monolayers with subsequent transfer them to a solid substrate by the Langmuir-Blodgett method is shown. Cobalt hexacyanoferrate nanoparticles were obtained by gradual mixing of an equimolar reagents mixture with the addition of sodium hexametaphosphate as a stabilizer. The size of nanoparticles were determined by the laser diffraction method, the size of their main number was about 12 nm. The hydrosol of the nanoparticles stability was studied photometrically in the pH range 2–4. The π-A octadecylamine monolayers isotherms on a subphase containing cobalt hexacyanoferrate nanoparticles were studied at the same pH values. According to the obtained data, optimal conditions for the monolayers transfer to a solid substrate by the Langmuir-Blodgett method were chosen. The morphology of the resulting films was studied on the surface of solid substrates. The electrochemical properties of electrodes based on Langmuir-Blodgett films in various solutions of electrolytes were studied by using the cyclic voltammetry and potentiometry.

In this article the possibility of obtaining Langmuir-Blodgett films on the basis of octadecylamine monolayers containing nanoparticles of hexacyanoferrates of various metals was shown. A comparison was made between different methods for obtaining these particles. Nanoparticles were produced using sodium hexametaphosphate as a stabilizer, their average size were determined by laser diffraction. The isotherms of compression were studied for monolayers on a subphase containing nanoparticles. Optimal conditions for the transfer of monolayers to a solid substrate were chosen according to the data obtained and their morphology was studied by scanning electron microscopy. The cyclic voltammetry method also confirmed the successful transfer of a monolayer to a solid substrate and showed the manifestation of the electrochemical properties of the obtained substrates.

Batch-type spectroscopic and continuous potentiometric titration of K4Mo2Cl8 with potassium dichromate in 1 M hydrochloric acid was carried out. Intermediate forms of molybdenum compounds in the oxidation process were determined. It was shown that the oxidation is accompanied by a rearrangement of the complex structure with the formation of trinuclear oxo- and hydroxohalide anions of molybdenum into trinuclear oxo- and hydroxohalide molybdenum anions. The standard reduction potential of the pair $$\rm{E}^o_{298}(Mo^{VI}/Mo^{IV}_3=1.003+0.032\;V$$ was determined.

Boiling curves of distilled water and isopropanol in 12.5x3x0.2 mm microchannel with rigid inlet and outlet lines are obtained. Critical heat flux is calculated for isopropanol by using the previously obtained correlation for water.

In this work, coatings of nanoparticles of aluminum oxide are investigated. Photos were obtained using an electron and optical microscope. A method is proposed for the formation of a coating of nanoparticles with and without agglomerates. The transport properties of nanoparticles of aluminum oxide, silicon carbide, titanium oxide and diamond have been investigated. The effect of agglomerates of nanoparticles on the rise of liquid has been determined.

(Jury. R. General. Protection. Nar. Health. 1897, April, No. 4, p. 276).

Heat transfer crisis was investigated during water boiling in a microchannel without coating and with coating of aluminum oxide nanoparticles. Experiments were performed on an advanced setup with a horizontally located microchannel with dimensions of 12.5x3x0.2 mm. Calculation of the critical heat flux in the microchannel without coating and with a coating from nanoparticles, carried out by formulas for heat transfer crisis in a horizontal pipe with microporous coating and one-sided heating. For the microchannel coated with nanoparticles the critical heat flux was calculated for the conditions of no influence of liquid subcooling and initial section. The satisfactory agreement between the experimental and calculated data was obtained. dependences of the critical heat flux from the coating thickness and characteristic size of particles were also shown. However, the data array is limited and needs to be expanded what will improve the equations for critical heat flux in a microchannel with nanoparticles coating.

In the work, porous coatings of alumina nanoparticles are investigated. The coatings were formed by various methods. The dependence of the lift height of the nanofluid on its volume was established. The properties of the coating are compared with and without microtrenches.

Film and drop condensation are important processes in technics. This article includes the features of macroscale heat transfer intensifiers under film condensation, microscale and nanoscale heat transfer intensifiers under drop condensation. It is noted that condensation heat transfer may be influenced by the wall material. The mechanism underlying this influence is the nonuniform distribution of the wall temperature in the case of a low heat conduction coefficient. Based on the research results, a dependence of the wetting angle from the combined coating consisting of 7 alumina oxide and water repellent is obtained.

Compression isotherms and chemical compositions of stearic acid (HSt) monolayers applied onto an aqueous subphase containing cadmium ions have been studied in a wide pH range. The data obtained have been used to calculate the dependences of surface elasticity E 2.5, change ΔA 2.5 in the surface area per molecule at a constant two-dimensional pressure in the monolayer of 2.5 mN/m, and change Δ|ζ| in the absolute value of the ζ potential of particles formed from the material of a monolayer collapsed on the surfaces of aqueous solutions with the same compositions on the pH of the subphase. The obtained data are in good agreement with each other and unambiguously attest to the dependences of the surface (E 2.5, ΔA 2.5) and electrosurface (Δ|ζ|) characteristics of the monolayers on their chemical composition. This leads us to make the reasonable suggestion that two alternative reactions may occur between cadmium ions and the HSt monolayer with the formation of two salts, CdSt2 and Cd(OH)St.

Octadecylamine (ODA)-based Langmuir-Blodgett films modified with metal hexacyanoferrates are promising ion-exchange systems. The analysis of compression isotherms has led to the conclusion that iron and copper hexacyanoferrates are embedded into ODA monolayers. Optimal conditions have been determined for transferring these hybrid films onto a solid substrate by the Langmuir-Blodgett method. The optimal time required for the formation of iron and copper hexacyanoferrates in the monolayer has been established with the use of spectrophotometric measurements. The transfer of ODA monolayers modified with iron and copper hexacyanoferrates onto a conducting substrate has been confirmed by atomic force microscopy. The EMF values of galvanic cells developed based on the ODA/Fe4[Fe(CN)6]3-KCl and ODA/Cu3[Fe(CN)6]2-NH4Cl systems have been shown to be close to the theoretical ones.

The thermal resistance of the composite thermal stabilizer and methods for its reduction are investigated. The thermal resistance of thermal stabilizer decreases due to the heat exchange intensification in evaporator by a layer of aluminum oxide nanoparticles. A method of producing aluminum oxide nanoparticles has been developed. The liquid capillary rise height is measured in the layer of nanoparticles. Estimate of the properties stability is obtained in the coating from aluminum oxide nanoparticles. The thermal resistance dependences are obtained on the transferred heat flux for models of thermal stabilizers from steel and aluminum

It was created the collection of the associative nitrogen-fixing bacteria from genera Aquaspirilium, Azospirillum, Rhodospirillum, Arthrobacter, Flavobacterium, Bacillus, isolated from rhizoplane of grain and fodder cereals, new fodder crops from families of Apiaceae, Brassicaceae, Asteraceae.

The First International Congress of Iranianists was held in Tehran in August and September 1966. On August 31, during a reception held by the Shah of Iran for the congress delegates in the Saadabad Palace, the Shah invited me to familiarize myself with the reforms being carried out in the country. This was the occasion for my trip to Iran, which lasted from December 20, 1967, until January 25, 1968.

(Doctor. 1897, No. 47 and 50, pp. 1419 and 1445).On the clinical side, this case was already described earlier (Rutkovsky. A rare case of uterine cancer.