64 results on '"N. Szabla"'
Search Results
2. Educational program in onco-urology for young urologists: What are their needs?
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Maxime Vallée, F. Bardet, N. Szabla, K. Kaulanjan, I. Dominique, T. Grevez, Clément Michiels, Lucas Freton, F. Lannes, E. Fortier, X. Matillon, Bastien Gondran-Tellier, Ugo Pinar, Zineddine Khene, M. Felber, Benjamin Pradere, E. Seizilles de Mazancourt, Groupe de Recherche Clinique Onco-Urologie Prédictive [CHU Tenon] (GRC 5), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pontchaillou [Rennes], Centre d'Urologie Prado Louvain [Marseille], Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe Hospitalier Diaconesses Croix Saint-Simon, Service de Biochimie Endocrinienne et Oncologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Urologie [CHU Pitié-Salpêtrière], Département Pathologie et Onco-biologie [CHU Montpellier], Pôle Biologie-Pathologie [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Service d'Urologie [CHU de Dijon], CHU Pointe-à-Pitre/Abymes [Guadeloupe], Hospices Civils de Lyon (HCL), Medizinische Universität Wien = Medical University of Vienna, and Gestionnaire, HAL Sorbonne Université 5
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Medical education ,medicine.medical_specialty ,Urologists ,Urology ,030232 urology & nephrology ,Formation médicale ,Computer-assisted web interviewing ,E-learning ,[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,Digital media ,Likert scale ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Surgical skills ,Humans ,Medicine ,Social media ,Internet ,Internes ,business.industry ,Residents ,Podcast ,4. Education ,Internship and Residency ,Evidence-based medicine ,[SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,3. Good health ,Onco-urologie ,Surgical education ,business ,Educational program - Abstract
PurposeThe emergence of new communication media such as digital contents are progressively replacing more traditional medias in the field of educational programs. Our purpose was to assess urologist in training aspirations regarding urological education.MethodsMembers of a national urologist in training association were sent an anonymous online questionnaire regarding their medical formation in the field of urology. Responders interest for urological sub-specialty or education support (new tools and traditional support) were evaluated through a 5-point Likert scale.ResultsOverall, 109 young urologists (26%) responded to the survey. Most of the respondents worked during their training in an academic hospital (n = 89, 82%). The three favorite tools for training chosen by the responders were: videos, workshop or masterclass, and podcasts (responders very interested were respectively n = 64 (58.7%), n = 50 (45.9%), and n = 49 (45%)). E-mail newsletters were reported as the less useful educational tool by participants (n = 38, 34.9%). Participants were very interested in improving their surgical skills and their radiological knowledge. Responders who were the most attracted by PCa were much more looking to improve their systemic treatment and radiological knowledges.ConclusionsUrologic-oncology was a priority regarding education for urologists in training. A majority of participants expressed a lack in their surgical education, revealing a reduced OR access and underlining utilization of new tools such as simulation. New digital contents such as social media or podcast achieved high interest for the participants, instead of more traditional media. There is a need that educational content evolve and uses new digital media., ButDans la formation médicale, les nouveaux médias de communication tels que les contenus numériques se développent très rapidement et tendent à remplacer les médias plus traditionnels. Notre objectif était d’évaluer les aspirations des urologues en matière de formation en onco-urologie.MatérielLes membres de l’Associations française des urologues en formation ont répondu à un questionnaire en ligne anonyme concernant leur formation en onco-urologie. L’intérêt des participants pour les différents moyens de formation ainsi que pour les spécialités d’organes ont été évalués avec une échelle de Likert à 5-points.RésultatsAu total, 109 urologues en formation ont répondu à l’enquête (26 %). La plupart ont effectué leur formation exclusivement dans un hôpital universitaire (n = 89, 82 %). Les trois outils de formation préférés des participants étaient : les supports vidéo, les ateliers ou masterclass, et les podcast (étaient très intéressés respectivement n = 64 (59 %), n = 50 (46 %) et n = 49 (45 %)). Les newsletters ont été considérées comme l’outil éducatif le moins utile (n = 39, 35 %). Les participants étaient très intéressés par l’amélioration de leurs compétences chirurgicales et de leurs connaissances radiologiques. Les participants qui s’intéressaient le plus au cancer de la prostate cherchaient à consolider leurs connaissances sur les traitements systémiques ainsi qu’en radiologie.ConclusionL’onco-urologie est une priorité pour les urologues en formation. Les nouveaux contenus numériques tels que les réseaux sociaux ou les podcasts ont suscité un grand intérêt chez les participants, supplantant les médias plus traditionnels. Il est nécessaire que le contenu éducatif évolue et se repose sur les nouveaux médias numériques.
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- 2021
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3. Residents and patients benefit from surgical simulation on a live porcine model, could we consider it as ethical?
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Zineddine Khene, Fungai Dengu, I. Dominique, Thomas Prudhomme, J.-Y. Deschamps, K. Kaulanjan, F. Lannes, Maxime Vallée, Julien Branchereau, F. Bardet, Ugo Pinar, E. Fortier, T. Grevez, N. Szabla, X. Matillon, Clément Michiels, E. de Mazancourt, Lucas Freton, Bastien Gondran-Tellier, M. Felber, and Benjamin Pradere
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medicine.medical_specialty ,Swine ,Urologists ,Urology ,media_common.quotation_subject ,education ,030232 urology & nephrology ,Live animal ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Animals ,Humans ,Computer Simulation ,media_common ,business.industry ,Internship and Residency ,Evidence-based medicine ,Emergency situations ,Surgical training ,Feeling ,Physical therapy ,Laparoscopy ,Clinical Competence ,Surgical simulation ,business ,Inclusion (education) - Abstract
Summary Introduction The objective was to evaluate, by self-questionnaire, the feeling of participants in surgical training sessions on a live porcine model. Methods A computerized questionnaire (GoogleForm ©) was sent to the members of the French Association of Urologists-in-Training (AFUF) (fellows and residents). Only questionnaires from Urologists-in-training who had participated in surgical training sessions were included. The sessions consisted of performing surgeries such as laparoscopic nephrectomies or laparoscopic cystectomies. Results Overall, 198 met the inclusion criteria. A total of 36.4% (72/198) of the participants were fellows and 63.6% (126/198) were residents. According to the participants, the main interest of sessions was to be able to train for emergency situations. A total of 79.8% (158/198) of the participants wanted surgical simulation to become compulsory. To their opinion, the main advantage of surgical simulation on a live porcine model was: technical progress in 87.4% (173/198) of cases. A total of 13.1% (26/198) of the participants found it was unethical to perform the first technical procedures on live animal models. A total of 65.7% (130/198) of the participants considered that there is currently no system of substitution. Conclusion For the participants, surgical training on a live porcine model allows technical progress while training for serious emergency situations. Surgeons and patients could benefit from this risk-free mock surgical scenario. Level of evidence 3.
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- 2021
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4. Recommandations françaises du Comité de transplantation de l’association française d’urologie (CTAFU) : Carcinome à cellules rénales du transplant rénal
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Arnaud Doerfler, N. Szabla, T. Culty, Marc-Olivier Timsit, T. Bessede, Gregory Verhoest, A. Mejean, G. Defortescu, Thomas Prudhomme, Karim Bensalah, Pierre Bigot, and Xavier Tillou
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medicine.medical_specialty ,education.field_of_study ,business.industry ,Urology ,medicine.medical_treatment ,Population ,030232 urology & nephrology ,Renal function ,urologic and male genital diseases ,medicine.disease ,Asymptomatic ,Nephrectomy ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Tumor stage ,Medicine ,Stage (cooking) ,medicine.symptom ,business ,education ,Clear cell - Abstract
OBJECTIVE To propose recommendations for the management of renal cell carcinomas (RCC) of the renal transplant. METHOD Following a systematic approach, a review of the literature (Medline) was conducted by the CTAFU to evaluate prevalence, diagnosis and management of RCC arousing in the renal transplant. References were assessed according to a predefined process to propose recommendations with levels of evidence. RESULTS Renal cell carcinomas of the renal transplant affect approximately 0.2% of recipients. Mostly asymptomatic, these tumors are mainly diagnosed on a routine imaging of the renal transplant. Predominant pathology is clear cell carcinomas but papillary carcinomas are more frequent than in general population (up to 40-50%). RCC of the renal transplant is often localized, of low stage and low grade. According to tumor characteristics and renal function, preferred treatment is radical (transplantectomy) or nephron sparing through partial nephrectomy (open or minimally invasive approach) or thermoablation after percutaneous biopsy. Although no robust data support a switch of immunosuppressive regimen, some authors suggest to favor the use of mTOR inhibitors. CTAFU does not recommend a mandatory waiting time after transplantectomy for RCC in candidates for a subsequent renal tranplantation when tumor stage
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- 2021
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5. Observation vs. early drainage for grade IV blunt renal trauma: a multicenter study
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Ines Dominique, P. Patard, Axelle Boehm, K. Guleryuz, Q. Langouet, R. Betari, X. Rod, Christian Pfister, Anthony Giwerc, P. Panayatopoulos, L. Sabourin, Jonathan Olivier, Thomas Caes, N. Brichart, Charles Dariane, Lucas Freton, Gaelle Fiard, S. Bergerat, Benoit Peyronnet, Benjamin Pradere, Cedric Lebacle, J. Rizk, A. Chebbi, Alexandre Gryn, Marina Ruggiero, M. Hutin, François-Xavier Nouhaud, N. Szabla, C. Millet, X. Matillon, and François-Xavier Madec
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Adult ,Male ,Nephrology ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Kidney ,Wounds, Nonpenetrating ,Young Adult ,03 medical and health sciences ,Injury Severity Score ,0302 clinical medicine ,Blunt ,Early Medical Intervention ,Internal medicine ,medicine ,Clinical endpoint ,Humans ,Watchful Waiting ,Retrospective Studies ,Upper urinary tract ,business.industry ,Stent ,Middle Aged ,Nephrectomy ,Surgery ,030220 oncology & carcinogenesis ,Cohort ,Drainage ,Female ,business - Abstract
The aim of this study was to compare observation and early drainage by ureteral stenting in patients with blunt renal trauma and urinary extravasation.A retrospective national multicenter study was performed including all patients admitted for renal trauma at 17 hospitals between 2005 and 2015. Patients presenting with a urinary extravasation on initial imaging were considered for inclusion. Patients were divided in two groups according to the initial approach: observation vs. early drainage by ureteral stent (within 48 h after admission). The primary endpoint was the persistence of urinary extravasation on follow-up imaging.Out of 1799 patients with renal trauma, 238 were included in the analysis (57 in the early drainage and 181 in the observation group). In the early drainage group, 29 patients had persistent urinary extravasation vs. 77 in the observation group (50.9% vs. 42.5%; p value = 0.27). The rates of secondary upper urinary tract drainage did not differ significantly between the early drainage group (26.4%) and the observation group (16%) (p = 0.14). There were no statistically significant differences between the two groups in terms of secondary nephrectomy (0% vs. 2.8%; p = 0.34), and death from trauma (0% vs. 1.8%; p = 0.99). In multivariate analysis, early drainage remained not statistically associated with persistence of urinary extravasation on follow-up imaging (OR = 1.35; p = 0.36) CONCLUSION: In this multicenter cohort, observation was not different from early drainage in terms of persistent urinary extravasation after grade IV blunt renal trauma. Further randomized controlled prospective trials are needed to confirm these findings.
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- 2020
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6. Traumatismes du rein
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T. Caes, S. Bergerat, X. Matillon, A. Chebbi, Traumafuf, François-Xavier Nouhaud, R. Betari, K. Guleryuz, L. Sabourin, M. Hutin, Gaelle Fiard, M. Ruggiero, P. Panayatopoulos, J. Rizk, Cedric Lebacle, Charles Dariane, Lucas Freton, Ines Dominique, François-Xavier Madec, C. Millet, N. Szabla, Alexandre Gryn, N. Brichart, J. Olivier, Benoit Peyronnet, Benjamin Pradere, P. Patard, and X. Rod
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Urology ,030232 urology & nephrology ,medicine ,business - Abstract
Resume Introduction Les traumatismes renaux sont frequents, retrouves dans 10 % de l’ensemble des traumatismes abdominaux. Ils sont majoritairement fermes, en rapport avec un choc direct ou une deceleration brutale. Materiel et methodes Nous avons une realise une synthese de la prise en charge des traumatismes du rein a destination des infirmieres et infirmiers. Resultats Les signes cliniques les plus frequents sont l’hematurie et la lombalgie. Le meilleur examen diagnostique est l’uroscanner. La classification la plus utilisee est celle de l’American Association for the Surgery of Trauma (AAST) qui classe les traumatismes renaux en 5 grades de gravite croissante sur la base des images scannographiques. Le traitement est conservateur dans l’immense majorite des cas et s’est largement simplifie ces dernieres annees, etant essentiellement base sur une surveillance clinique. Les traitements radio-interventionnels et endoscopiques sont reserves a des cas tres selectionnes et le recours a l’exploration chirurgicale est exceptionnel. Conclusion Le pronostic s’est egalement considerablement ameliore et les traumatismes renaux aboutissent desormais tres rarement au deces ou a la perte du rein.
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- 2019
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7. [Late complications after blunt renal trauma: A French multicenter study]
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G, Brenot, I, Dominique, B, Peyronnet, P H, Savoie, P, Chiron, and N, Szabla
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Hypertension ,Humans ,Hemorrhage ,Kidney ,Wounds, Nonpenetrating ,Retrospective Studies - Abstract
Among genitourinary traumas, blunt trauma to the kidney are the most frequent: their initial management has been well studied but their development at a distance is poorly documented. The objective of this study was to assess the late complications of blunt renal trauma, and to investigate their predictive factors for occurrence.A retrospective observational study of the TraumAFUF project was conducted, including, between 2005 and 2018, all blunt renal trauma treated in 18 French hospitals and followed for more than 3 months. The characteristics of the initial trauma, as well as any complications occurring after three months, were identified. The patients were divided into two groups: onset of a late complication (LC) or uncomplicated (UC). The groups were compared in univariate and multivariate analyses to identify the risk factors for the occurrence of these complications.Among the 454 patients included, 50 presented with LC (11%), as symptomatic morphologically altered kidney (2.9%), secondarily impaired biological renal function (2.9%), or secondary arterial hypertension (2.4%). The risk factors identified were, during initial medical care, a high-grade renal trauma≥IV (OR=2.4, P=0.025), active bleeding (OR=2.6, P=0.007), the need for transfusion (OR=2.3, P=0.001), or interventional (R=1.7, P=0.09) or endoscopic treatment (OR=2.0, P=0.035).In this study, late complications occurred in 11% of cases after blunt renal trauma. The risk factors identified make it possible to draw up a patient profile who would benefit from prolonged follow-up to detect these complications.
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- 2021
8. Factors Predictive of Selective Angioembolization Failure for Moderate- to High-grade Renal Trauma: A French Multi-institutional Study
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C. Millet, Thomas Caes, A. Chebbi, Charles Dariane, Lucas Freton, Ines Dominique, N. Szabla, J. Rizk, Marina Ruggiero, Benoit Peyronnet, François-Xavier Madec, Benjamin Pradere, François-Xavier Nouhaud, Bastien Gondran-Tellier, R. Betari, P. Patard, Gaelle Fiard, M. Hutin, X. Rod, Jonathan Olivier, X. Matillon, Cedric Lebacle, Paul Panayotopoulos, S. Bergerat, Michael Baboudjian, and L. Sabourin
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medicine.medical_specialty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Logistic regression ,Kidney ,Wounds, Nonpenetrating ,Nephrectomy ,03 medical and health sciences ,0302 clinical medicine ,parasitic diseases ,Medicine ,Humans ,In patient ,Embolization ,Patient summary ,Hematuria ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Odds ratio ,Confidence interval ,Surgery ,030220 oncology & carcinogenesis ,Angiography ,business - Abstract
Background Angiography with selective angioembolization (SAE) is safe and effective in addressing bleeding in patients with renal trauma. However, there are no validated criteria to predict SAE efficacy. Objective To evaluate factors predictive of SAE failure after moderate- to high-grade renal trauma. Design, setting, and participants TRAUMAFUF was a retrospective multi-institutional study including all patients who underwent upfront SAE for renal trauma in 17 French hospitals between 2005 and 2015. Outcome measurements and statistical analysis The primary outcome was SAE efficacy, defined as the absence of repeat SAE, salvage nephrectomy, and/or death for each patient. Results and limitations Out of 1770 consecutive patients with renal trauma, 170 (9.6%) with moderate- to high-grade renal trauma underwent SAE. Overall upfront SAE was successful in 131 patients (77%) and failed in 39 patients: six patients died after the embolization, ten underwent repeat SAE, 22 underwent open nephrectomy, and one underwent open surgical exploration. In multivariate logistic regression analysis, gross hematuria (odds ratio [OR] 3.16, 95% confidence interval [CI] 1.29–8.49; p = 0.015), hemodynamic instability (OR 3.29, 95% CI 1.37–8.22; p = 0.009), grade V trauma (OR 2.86, 95% CI 1.06–7.72; p = 0.036), and urinary extravasation (OR 3.49, 95% CI 1.42–8.83; p = 0.007) were predictors of SAE failure. The success rate was 64.7% (22/34) for patients with grade V trauma and 59.6% (31/52) for those with hemodynamic instability. The study was limited by its retrospective design and the lack of a control group managed with either surgery or surveillance. Conclusions We found that gross hematuria, hemodynamic instability, grade V trauma, and urinary extravasation were significant predictors of SAE failure. However, success rates in these subgroups remained relatively high, suggesting that SAE might be appropriate for those patients as well. Patient summary Selective angioembolization (SAE) is a useful alternative to nephrectomy to address bleeding in patients with renal trauma. Currently, there are no validated criteria to predict SAE efficacy. We found that gross hematuria, hemodynamic instability, grade V trauma, and urinary extravasation were significant predictors of SAE failure.
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- 2020
9. COVID19 pandemic impacts on anxiety of French urologist in training: Outcomes from a national survey
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X. Matillon, F. Lannes, Guillaume Ploussard, E. Seizilles de Mazancourt, K. Kaulanjan, Morgan Rouprêt, T. Grevez, E. Fortier, Ugo Pinar, F. Bardet, Ines Dominique, Vincent Misraï, Zine-Eddine Khene, Maher Abdessater, Maxime Vallée, N. Szabla, Lucas Freton, Clément Michiels, Bastien Gondran-Tellier, M. Felber, Benjamin Pradere, and J. Boustany
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Adult ,Male ,medicine.medical_specialty ,Urologists ,Urology ,education ,Pneumonia, Viral ,030232 urology & nephrology ,Burnout ,Anxiety ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Pandemic ,Medical Staff, Hospital ,Medicine ,Humans ,Pandemics ,Past medical history ,business.industry ,COVID-19 ,Internship and Residency ,Front line ,Evidence-based medicine ,Family medicine ,Female ,France ,medicine.symptom ,business ,Coronavirus Infections ,Psychosocial - Abstract
Summary Introduction The COVID-19 outbreak in France is disturbing our health system. Urologists in training who are already known to have burnout, are in the front line to face this disease. The aim of our study was to assess the psychological impact of COVID-19 pandemic on young French urologists in training. Material and methods A self-administered anonymous questionnaire evaluating the pandemic added stress, and its negative impact on work and training quality, was e-mailed to the members of the French Association of Urologists in Training (AFUF). The association includes all French junior and senior residents. The survey lasted 3 days. Multivariable analyses using logistic regression was performed to identify the predictive factors. Results Two hundred and seventy-five (55.5%) of the 495 AFUF members responded to the questionnaire. More than 90% of responders felt more stressed by the pandemic. Fellows and senior residents were more likely to feel that the crisis had an important impact on their work quality (OR = 1.76, IC95 = [1.01–3.13]), even more when COVID 19 patients were present in their department (OR = 2.31, IC95 = [1.20–4.65]). Past medical history of respiratory disease (OR = 2.57, IC95 = [1.31–5.98]) and taking in charge COVID19 patients (OR = 1.85, IC95 = [0.98–3.59]) were additional risk factors. Conclusion COVID19 pandemic has a negative impact on young French urologists in training and on their work and training quality. Managing their psychosocial well-being during this time is as important as managing their physical health. Level of evidence 3.
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- 2020
10. COVID-19 outbreak situation and its psychological impact among surgeons in training in France
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Xavier Matillon, Ines Dominique, M. Felber, T. Grevez, Lucas Freton, Benjamin Pradere, E. Fortier, Zine-Eddine Khene, F. Lannes, N. Szabla, Maxime Vallée, Vincent Misrai, Bastien Gondran-Tellier, Clément Michiels, Emilien Seizilles de Mazancourt, Ugo Pinar, Guillaume Ploussard, Morgan Rouprêt, K. Kaulanjan, F. Bardet, and Maher Abdessater
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Adult ,Male ,Surgeons ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,SARS-CoV-2 ,Urology ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Outbreak ,COVID-19 ,Correction ,Education, Medical, Graduate ,Family medicine ,General Surgery ,Pandemic ,medicine ,Humans ,Female ,France ,business ,Pandemics ,Stress, Psychological - Published
- 2020
11. [Renal cell carcinoma of the kidney transplant: The French guidelines from CTAFU]
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X, Tillou, A, Doerfler, N, Szabla, G, Verhoest, G, Defortescu, T, Bessede, T, Prudhomme, T, Culty, P, Bigot, K, Bensalah, A, Méjean, and M-O, Timsit
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Postoperative Complications ,Humans ,Carcinoma, Renal Cell ,Kidney Transplantation ,Kidney Neoplasms - Abstract
To propose recommendations for the management of renal cell carcinomas (RCC) of the renal transplant.Following a systematic approach, a review of the literature (Medline) was conducted by the CTAFU to evaluate prevalence, diagnosis and management of RCC arousing in the renal transplant. References were assessed according to a predefined process to propose recommendations with levels of evidence.Renal cell carcinomas of the renal transplant affect approximately 0.2% of recipients. Mostly asymptomatic, these tumors are mainly diagnosed on a routine imaging of the renal transplant. Predominant pathology is clear cell carcinomas but papillary carcinomas are more frequent than in general population (up to 40-50%). RCC of the renal transplant is often localized, of low stage and low grade. According to tumor characteristics and renal function, preferred treatment is radical (transplantectomy) or nephron sparing through partial nephrectomy (open or minimally invasive approach) or thermoablation after percutaneous biopsy. Although no robust data support a switch of immunosuppressive regimen, some authors suggest to favor the use of mTOR inhibitors. CTAFU does not recommend a mandatory waiting time after transplantectomy for RCC in candidates for a subsequent renal tranplantation when tumor stageT3 and low ISUP grade.These French recommendations should contribute to improving the oncological and functional prognosis of renal transplant recipients by improving the management of RCC of the renal transplant.
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- 2020
12. Impact of hospital volume on the outcomes of renal trauma management
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P. Baloche, N. Szabla, L. Freton, M. Hutin, M. Ruggiero, I. Dominique, C. Millet, S. Bergerat, P. Panayotopoulos, R. Betari, X. Matillon, A. Chebbi, T. Caes, P-M. Patard, N. Brichart, C. Dariane, M. Baboudjian, B. Gondran-Tellier, C. Lebacle, F-X. Madec, F-X. Nouhaud, X. Rod, G. Fiard, B. Pradere, and B. Peyronnet
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Urology - Published
- 2022
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13. Early mobilization is safe after renal trauma: A multicenter study
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S. Bergerat, Thomas Caes, Jonathan Olivier, R. Betari, B. Pradere, Ines Dominique, Charles Dariane, Lucas Freton, F-X.R. Madec, Alexandre Gryn, K. Guleryuz, M. Hutin, B. Peyronnet, P. Panayatopoulos, C. Millet, G. Fiard, N. Szabla, A. Bohem, A. Chebbi, L. Sabourin, X. Rod, Thomas Prudhomme, F.X. Nouhaud, Cedric Lebacle, N. Brichart, P.M. Patard, J. Rizk, and Marina Ruggiero
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Multicenter study ,business.industry ,030220 oncology & carcinogenesis ,Urology ,Emergency medicine ,030232 urology & nephrology ,medicine ,Early mobilization ,business - Published
- 2018
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14. Pyelo-colic fistula: CT-scan
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N. Szabla, A. Alves, and Xavier Tillou
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medicine.medical_specialty ,Pyelonephritis ,medicine.diagnostic_test ,Urinary Fistula ,business.industry ,medicine.medical_treatment ,Fistula ,Computed tomography ,General Medicine ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Transplant Recipients ,Nephrectomy ,Colonic Diseases ,Intestinal Fistula ,medicine ,Humans ,Kidney Diseases ,Radiology ,Tomography, X-Ray Computed ,business ,Colectomy - Published
- 2019
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15. Y a-t-il un effet centre dans la prise en charge des traumatismes du rein ?
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I. Dominique, P. Baloche, R. Betari, P.M. Patard, A. Chebbi, C. Millet, P. Panayotopoulos, N. Brichart, B. Peyronnet, M. Hutin, Cedric Lebacle, Bastien Gondran-Tellier, S. Bergerat, N. Szabla, M. Ruggiero, B. Pradere, Charles Dariane, Lucas Freton, T. Caes, and X. Matillon
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Published
- 2021
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16. Étude multicentrique française de la mortalité à trente jours après un traumatisme rénal
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A. Chebbi, Jonathan Olivier, P. Panayatopoulos, M. Ruggiero, B. Pradere, Lucas Freton, P.M. Patard, R. Betari, B. Peyronnet, I. Dominique, M. Hutin, Bastien Gondran-Tellier, T. Caes, X. Matillon, C. Millet, N. Szabla, Michael Baboudjian, Cedric Lebacle, G. Fiard, and S. Bergerat
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Bien que l’incidence et les mecanismes des traumatismes renaux soient bien connus, la mortalite due aux lesions renales et les facteurs de risque a l’origine de ces deces restent peu documentes. L’objectif etait de rapporter la mortalite a 30 jours (30DM) apres un traumatisme renal et identifier les facteurs de risque associes au deces. Methodes Le projet TRAUMAFUF etait une etude retrospective multi-institutionnelle francaise incluant tous les patients consecutifs ayant ete admis pour un traumatisme renal dans 17 hopitaux entre 2005 et 2015. La population incluse comprenait des patients de tous âges ayant eu un traumatisme renal au cours de la periode d’etude, sans criteres d’exclusion. Le critere de jugement principal etait la survenue d’un deces dans les 30 jours suivant le traumatisme. Un modele de regression logistique multivariee a ete utilise pour identifier les facteurs predictifs de 30DM. Resultats Au total, 1799 patients ont ete admis pour un traumatisme renal pendant la periode d’etude. Cinquante-neuf deces dans les 30 jours suivant le traumatisme renal sont survenus (30 DM = 3,27 %). Le traumatisme renal etait directement implique dans 5 deces (8,5 % de tous les deces, 0,3 % de tous les traumatismes renaux). En analyse multivariee, un âge > 40 ans (OR : 2,18 ; IC95 % : 1,20–3,99 ; p = 0,01), l’instabilite hemodynamique (OR : 4,67 ; IC95 % : 2,49–9 ; p Conclusion Notre etude multicentrique rapporte que la 30DM de 3,27 % apres un traumatisme renal etait essentiellement associee aux lesions concomitantes. Un âge > 40 ans, une instabilite hemodynamique, une anemie, un traumatisme renal bilateral, une extravasation vasculaire et des lesions viscerales et osseuses concomitantes etaient des facteurs predictifs de deces. Ces resultats peuvent aider les cliniciens a identifier les patients a haut risque.
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- 2021
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17. TORSAFUF : exploration testiculaire pour suspicion de torsion du cordon spermatique : résultats périopératoires d’une cohorte nationale Française de 2940 patients
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I. Duquesne, E. Seizilles de Mazancourt, Maxime Vallée, F. Bardet, K. Kaulanjan, M. Felber, N. Ali Benali, B. Pradere, Lucas Freton, X. Matillon, N. Szabla, A. Mauger De Varennes, F. Lannes, T. Grevez, Zineddine Khene, C. Plassais, Ugo Pinar, E. Fortier, I. Dominique, and Clément Michiels
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs La torsion du cordon spermatique est une urgence chirurgicale fonctionnelle, touchant principalement les adolescents mais aussi les jeunes adultes. L’objectif de cette etude etait de presenter les donnees epidemiologiques des explorations chirurgicales pour suspicion de torsion du cordon spermatique. Methodes Les caracteristiques demographiques, cliniques, paracliniques, peroperatoires et postoperatoires ont ete recueillies de maniere retrospective dans 14 centres hospitalo-universitaires francais chez 2986 patients âges de 12 ans et plus, ayant eu une exploration chirurgicale entre 2005 et 2009 (cohorte TORSAFUF). Quarante-six pour cent patients ont ete exclus de l’etude par manque de donnees concernant leur statut peroperatoire. Deux groupes ont ete definis selon le statut peroperatoire de torsion du cordon spermatique. Resultats Au total, 2940 patients ont eu une exploration chirurgicale, 1802 (61,29 %) presentaient une torsion du cordon spermatique, 1138 (38,70 %) presentaient un autre diagnostic dont 802 (70,47 %) ont eu une exploration chirurgicale blanche ( Fig. 1 A). Les caracteristiques demographiques et perioperatoires de notre population sont presentees dans les Tableau 1 , Tableau 2 . Le type de geste chirurgical realise selon le statut « tordu/non tordu » est represente en Fig. 1 B. Une complication postoperatoire dans les 90 jours etait presente chez 198 patients (10,98 %) de la population « tordu », dont la plus frequente etait le retard de cicatrisation (43,43 %), et chez 111 patients (9,75 %) dans la population n’ayant pas de torsion du cordon spermatique, avec 37 orchites (33,33 %). Conclusion La torsion du cordon spermatique, dont la presentation clinique est souvent decrite comme classique, n’est pourtant confirmee que dans environ 60 % des cas, entrainant pres de 40 % de gestes chirurgicaux inutiles. Notre etude souligne l’importance de trouver des elements diagnostiques cliniques et paracliniques complementaires qui pourraient permettre de limiter les interventions chirurgicales inutiles.
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- 2020
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18. [Renal Trauma]
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L, Freton, B, Pradere, G, Fiard, A, Chebbi, T, Caes, M, Hutin, J, Olivier, M, Ruggiero, I, Dominique, C, Millet, S, Bergerat, P, Panayatopoulos, R, Betari, P-M, Patard, N, Szabla, N, Brichart, L, Sabourin, K, Guleryuz, C, Dariane, C, Lebacle, J, Rizk, A, Gryn, F-X, Madec, X, Rod, F-X, Nouhaud, X, Matillon, and B, Peyronnet
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Humans ,Abdominal Injuries ,Kidney - Abstract
Renal traumas are common, observed in 10% of patients with abdominal trauma. Most renal traumas are blunt, resulting from a direct hit or from an abrupt deceleration.We realized a synthesis of renal trauma management for nurses.Clinical presentation often encompasses gross hematuria and lumbar pain. The best diagnostic tool is computed tomography (CT) urogram. Based on CT urogram images, renal traumas are classified according to the American Association for the Surgery of Trauma (AAST) classification in five grades of increasing severity. The management is conservative in the vast majority of cases and has been largely simplified over the past few years, being now mostly based on observation. Radiological interventional and endoscopic procedures are used only in very selected cases and surgical exploration has become extremely rare.The prognosis has also considerably improved and renal trauma rarely result in death or loss of the kidney nowadays.
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- 2019
19. Simulation chirurgicale sur modèle vivant porcin : enquête auprès des urologues français en formation
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J.-Y. Deschamps, Julien Branchereau, Zineddine Khene, T. Grevez, N. Szabla, I. Dominique, Clément Michiels, F. Lannes, Bastien Gondran-Tellier, Ugo Pinar, Thomas Prudhomme, E. Seizilles de Mazancourt, E. Fortier, F. Bardet, B. Pradere, X. Matillon, K. Kaulanjan, Maxime Vallée, and M. Felber
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs L’apprentissage des interventions chirurgicales sur un modele animal vivant est souvent considere comme necessaire pour les chirurgiens en formation afin de ne pas effectuer les premiers gestes techniques chez les patients humains. L’objectif de cette etude etait d’evaluer l’interet de la simulation chirurgicale sur modele vivant porcin, pour les participants aux sessions de formation chirurgicale. Methodes Un questionnaire informatise (GoogleForm ©) a ete envoye aux membres de l’Association francaise des urologues en formation (AFUF) (internes et CCA/assistants). Seuls les questionnaires des urologues en formation ayant participe a des seances de simulation chirurgicale sur modele vivant porcin ont ete inclus. Ces sessions consistaient a realiser des interventions chirurgicales telles que des nephrectomies ou des cystectomies par laparoscopie. Chaque session commencait par une reunion definissant les objectifs et se terminait par un debriefing. Resultats Cent quatre-vingt-dix-huit questionnaires repondaient aux criteres d’inclusion. Parmi les participants, 36,4 % (72/198) etaient des CCA/assistants et 63,6 % (126/198) des internes. Selon les participants, l’interet principal des sessions etait de pouvoir s’entrainer a des situations d’urgence. Parmi les participants, 79,8 % (158/198) souhaitaient que la simulation chirurgicale devienne obligatoire. Selon eux, les avantages de la simulation chirurgicale sur un modele vivant de porc etaient les suivants : progres technique dans 87,4 % (173/198) des cas et meilleure anticipation du deroulement d’une procedure chirurgicale dans 72,7 % (144/198) des cas. Parmi les participants, 13,1 % (26/198) ont estime qu’il etait contraire a l’ethique d’effectuer les premieres procedures techniques sur des modeles d’animaux vivants. Parmi les participants, 65,7 % (130/198) ont estime qu’il n’existe pas actuellement de systeme de substitution. Conclusion Pour les participants, la formation chirurgicale sur un modele vivant de porc permet de progresser techniquement tout en s’entrainant a des situations d’urgence graves. Les chirurgiens et les patients pourraient beneficier de ce scenario chirurgical simule sans risque.
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- 2020
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20. Exploration chirurgicale d’une douleur testiculaire aiguë suspecte de torsion du cordon spermatique chez l’adulte : étude d’une population de 468 cas
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E. Seizilles de Mazancourt, Clément Michiels, M. Chabenes, F. Lannes, B. Pradere, M. Hulin, V. Dang, C. Plassais, N. Szabla, Ugo Pinar, A. Manuguerra, V. Gaillard, K. Kaulanjan, I. Dominique, C. Gaillard, F. Bardet, Maxime Vallée, Zineddine Khene, A. Mauger De Varennes, and X. Matillon
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs La douleur testiculaire aigue (DTA) est un motif frequent de consultation aux urgences. Bien connue des pediatres de par l’urgence chirurgicale que represente la torsion du cordon spermatique (TCS), elle ne doit pas etre negligee chez l’adulte. L’objectif de cette etude etait d’analyser les caracteristiques demographiques et perioperatoires des DTA explorees au bloc operatoire chez les patients adultes de plus de 30 ans. Methodes Il s’agit d’une une etude multicentrique retrospective nationale (TorsAFUF) qui a inclus tous les patients adultes de plus de 30 ans pris en charge pour une DTA suspecte de TCS dans 14 centres hospitaliers. Les caracteristiques demographiques, les donnees peroperatoires et postoperatoires ont ete recueillies. Une regression logistique a ete realisee pour rechercher les facteurs associes a une TCS dans cette population particuliere. Resultats L’etude a inclut 486 patients ( Tableau 1 ). L’âge median etait de 36 ans (32–41) La douleur testiculaire brutale a ete le signe fonctionnel le plus frequent (81,84 %). Une echographie preoperatoire a ete realisee chez 39 % des patients, ayant permis le diagnostic de TCS dans un quart des cas. Le delai entre l’arrivee des patients aux urgences et l’exploration scrotale etait de 8 h. L’exploration chirurgicale a identifie une TCS chez 46,1 % des patients. Une orchidectomie a ete realisee chez 1 patient sur 10. Les suites operatoires ont ete simples dans 87 % des cas. En analyse multivariee, seule la position ascensionnee du testicule semblait apparaitre comme un facteur predictif de TCS dans cette population (OR = 2,81, p = 0,01) ( Tableau 2 ). Conclusion Ces donnees soulignent la prevalence significative de la TCS chez les patients adultes de plus de 30 ans et la position ascensionnee du testicule a l’examen physique semble etre le signe clinique le plus predictif dans cette population.
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- 2020
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21. Correction to: COVID-19 outbreak situation and its psychological impact among surgeons in training in France
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Clément Michiels, Guillaume Ploussard, Morgan Rouprêt, Xavier Matillon, F. Bardet, Maher Abdessater, T. Grevez, Bastien Gondran-Tellier, N. Szabla, K. Kaulanjan, M. Felber, Maxime Vallée, Emilien Seizilles de Mazancourt, Ines Dominique, Benjamin Pradere, Zine Eddine Khene, Lucas Freton, E. Fortier, F. Lannes, Vincent Misrai, and Ugo Pinar
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Urology ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Data_MISCELLANEOUS ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,030232 urology & nephrology ,MEDLINE ,Outbreak ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Family medicine ,Correct name ,Medicine ,business - Abstract
In the original publication of the article, the first and last name of the first author were interchanged. The correct name of the author should be as given below.
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- 2020
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22. PD02-11 EARLY DISCHARGE IN PATIENTS WITH LOW GRADE RENAL TRAUMA: ON THE WAY TO OUTPATIENT MANAGEMENT? RESULTS OF THE TRAUMAFUF MULTICENTRE STUDY
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Xavier Rod, Ines Dominique, S. Bergerat, P. Patard, Gaelle Fiard, François-Xavier Nouhaud, Alexandre Gryn, M. Hutin, Jerome Rizk, K. Guleryuz, Xavier Matillon, L. Sabourin, P. Panayatopoulos, François-Xavier Madec, Charles Dariane, Cedric Lebacle, Marina Ruggiero, C. Millet, N. Szabla, Thomas Caes, Benoit Peyronnet, Benjamin Pradere, Axelle Bohem, A. Chebbi, Lucas Freton, Nicolas Brichart, Jonathan Olivier, Lucie-Marie Scailteux, Q. Langouet, and R. Betari
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medicine.medical_specialty ,business.industry ,Urology ,Emergency medicine ,Medicine ,In patient ,business ,Outpatient management ,Early discharge - Published
- 2018
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23. PD02-10 WHICH IS THE PLACE FOR IMMEDIATE RADIO-EMBOLIZATION IN THE MANAGEMENT OF HEMODYNAMICALLY INSTABLE PATIENTS WITH KIDNEY TRAUMA ? RESULTS OF THE MULTICENTRIC NATIONAL FRENCH STUDY TRAUMAFUF
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Marina Ruggiero, N. Szabla, François-Xavier Madec, François-Xavier Nouhaud, Xavier Rod, Ines Dominique, Paul Panayotopoulos, Gaelle Fiard, C. Millet, Thomas Prudhomme, Axelle Boehm, Charles Dariane, Alexandre Gryn, Nicolas Brichart, Jerome Rizk, R. Betari, Benoit Peyronnet, Benjamin Pradere, P. Patard, Cedric Lebacle, S. Bergerat, M. Hutin, L. Sabourin, A. Chebbi, Lucas Freton, Jonathan Olivier, Thomas Caes, and K. Guleryuz
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Kidney ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Urology ,medicine.medical_treatment ,medicine ,Embolization ,business ,Surgery - Published
- 2018
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24. Risk factors for death after renal trauma: Results of the French multicenter study TRAUMAFUF
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Ines Dominique, J. Rizk, G. Fiard, Alexandre Gryn, X. Matillon, C. Millet, N. Szabla, Paul Panayotopoulos, Marina Ruggiero, A. Boehm, F.X. Nouhaud, S. Bergerat, A. Chebbi, P-M. Patard, K. Guleryuz, R. Betari, X. Rod, Cedric Lebacle, B. Peyronnet, F-X.R. Madec, Thomas Caes, L. Sabourin, M. Hutin, Jonathan Olivier, B. Pradere, Charles Dariane, Lucas Freton, and N. Brichart
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medicine.medical_specialty ,Multicenter study ,business.industry ,Urology ,Emergency medicine ,medicine ,business - Published
- 2019
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25. PD63-04 ROLE OF REPEAT IMAGING IN RENAL TRAUMA MANAGEMENT : RESULTS OF A FRENCH MULTICENTRIC STUDY (TRAUMAFUF)
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Gaelle Fiard, Jonathan Olivier, L. Sabourin, P. Patard, M. Hutin, Q. Langouet, Jerome Rizk, R. Betari, Marine Ruggiero, Charles Dariane, Xavier Rod, Ines Dominique, Nicolas Brichart, N. Szabla, Xavier Matillon, François-Xavier Nouhaud, Cedric Lebacle, François-Xavier Madec, Benoit Peyronnet, Benjamin Pradere, P. Panayatopoulos, C. Millet, S. Bergerat, Lucas Freton, K. Guleryuz, Thomas Caes, and A. Chebbi
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03 medical and health sciences ,medicine.medical_specialty ,Pediatrics ,0302 clinical medicine ,Trauma management ,business.industry ,Urology ,Emergency medicine ,030232 urology & nephrology ,medicine ,business - Published
- 2017
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26. PD63-08 EARLY MOBILIZATION IS SAFE AFTER RENAL TRAUMA : A MULTICENTER STUDY
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Gaelle Fiard, Jonathan Olivier, K. Guleryuz, N. Szabla, Lucas Freton, Q. Langouet, Marina Ruggiero, R. Betari, L. Sabourin, Xavier Rod, Benoit Peyronnet, Ines Dominique, Benjamin Pradere, Jerome Rizk, A. Chebbi, Axelle Bohem, Nicolas Brichart, François-Xavier Nouhaud, Thomas Caes, François-Xavier Madec, Xavier Matillon, M. Hutin, Cedric Lebacle, C. Millet, Alexandre Gryn, P. Patard, Paul Panayotopoulos, Charles Dariane, and S. Bergerat
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medicine.medical_specialty ,Multicenter study ,business.industry ,Urology ,Medicine ,Early mobilization ,business ,Intensive care medicine - Published
- 2017
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27. Role of repeat imaging in renal trauma management: Results of a French multicentric study (TRAUMAFUF)
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R. Betari, J. Olivier, B. Pradere, M. Ruggiero, I. Dominique, L. Freton, C. Millet, S. Bergerat, P. Panayatopoulos, T. Caes, A. Chebbi, P.M. Patard, N. Szabla, C. Dariane, C. Lebacle, J. Rizk, X. Rod, G. Fiard, and B. Peyronnet
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Urology - Published
- 2018
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28. Risk factors for failure of conservative management in blunt renal trauma: Results of a French national multicenter study (TRAUMAFUF)
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N. Szabla, J. Rizk, Q. Langouet, Thomas Caes, Alexandre Gryn, R. Betari, K. Guleryuz, Marina Ruggiero, P.M. Patard, O. Olivier, C. Millet, A. Bohem, S. Bergerat, A. Chebbi, Ines Dominique, François-Xavier Madec, F.X. Nouhaud, B. Pradere, P. Panayatopoulos, G. Fiard, Charles Dariane, Lucas Freton, L. Sabourin, B. Peyronnet, X. Matillon, Cedric Lebacle, X. Rod, M. Hutin, and N. Brichart
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medicine.medical_specialty ,Blunt ,Multicenter study ,Conservative management ,business.industry ,Urology ,General surgery ,Medicine ,business - Published
- 2018
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29. Quelle est la place de la radio-embolisation en urgence dans la prise en charge de patients traumatisés rénaux en instabilité hémodynamique ? Résultats de l’étude multicentrique nationale TRAUMAFUF
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M. Ruggiero, Ines Dominique, B. Peyronnet, Lucas Freton, Q. Langouet, S. Bergerat, Jonathan Olivier, A. Chebbi, R. Betari, P. Patard, P. Panayotopoulos, N. Szabla, T. Caes, X. Matillon, and N. Brichart
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs La plupart des societes savantes recommandent une laparotomie en urgence chez les patients traumatises renaux arrives en instabilite hemodynamique (chirurgie « damage control »). Au cours des 10 dernieres annees, la radio-embolisation s’est largement developpee. Toutefois sa place chez les traumatises renaux en instabilite hemodynamique n’a jamais ete evaluee. L’objectif de cette etude etait d’evaluer la place pratique de l’embolisation dans la prise en charge de ces patients. Methodes Nous avons conduit l’etude multicentrique retrospective nationale TRAUMAFUF incluant les patients pris en charge pour un traumatisme renal dans 15 centres hospitaliers entre 2005 et 2015. L’instabilite hemodynamique etait definie par une pression arterielle systolique Resultats Parmi une cohorte de 1287 patients, 240 patients (18,6 %) etaient arrives en instabilite hemodynamique. Neuf patients n’avaient pas eu de scanner a l’entree. Trente-huit patients ont ete embolises, dont 2 n’avaient pas eu de scanner d’evaluation initiale. Six patients (15,8 %) avaient un traumatisme de grade 3, 27 (71,1 %) de grade 4 (21 vasculaires et 6 urinaires) et 5 (13,2 %) de grade 5. Vingt-quatre patients avaient des lesions viscerales et 23 des lesions osseuses associees. Dix patients (26,3 %) avaient eu un traitement complementaire : 2 chirurgies (5,3 %), 3 embolisations de faux anevrysmes (7,9 %) et 5 traitements endo-urologiques (13,2 %). Six patients (15,8 %) etaient hospitalises moins d’une semaine et 30 (78,9 %) moins d’un mois. Cinq patients (13,2 %) ont necessite une rehospitalisation. Un patient (2,6 %) a ete suivi a long terme pour une insuffisance renale chronique et 4 patients (10,5 %) etaient decedes. Conclusion Dans cette etude multicentrique, l’embolisation en radiologie interventionnelle precoce des patients arrives en instabilite hemodynamique semblait etre une option therapeutique efficace et bien toleree : complications et duree d’hospitalisation etaient limitees. Au vu de ces donnees, la radio-embolisation pourrait avoir une place chez les patients en instabilite hemodynamique en raison d’un traumatisme renal.
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- 2017
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30. Comparaison des caractéristiques et de la prise en charge des traumatismes rénaux entre la population adulte et pédiatrique
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J. Rizk, F.X. Nouhaud, P. Patard, M. Hutin, A. Chebbi, K. Guleryuz, L. Sabourin, T. Caes, Alexandre Gryn, N. Brichart, X. Rod, O. Abbo, Benjamin Pradere, X. Matillon, François-Xavier Madec, Q. Langouet, Charles Dariane, Lucas Freton, M. Ruggiero, G. Fiard, Cedric Lebacle, C. Millet, S. Bergerat, B. Peyronnet, Jonathan Olivier, P. Panayatopoulos, Ines Dominique, N. Szabla, and R. Betari
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Les traumatismes renaux representent les traumatismes genito-urinaires les plus frequents. A l’âge pediatrique, les lesions sont classiquement decrites comme differentes en raison, notamment des lesions associees et du mecanisme lesionnel. Neanmoins, il n’existe aucune donnee dans la litterature comparant ces traumatismes et leur prise en charge en fonction de l’âge. L’objectif de cette etude etait de comparer les caracteristiques des traumatismes renaux chez l’adulte et l’enfant. Methodes Une etude multicentrique retrospective nationale (TRAUMAFUF) a ete conduite, incluant tous les patients pris en charge pour traumatisme du rein dans 15 centres hospitaliers entre 2005 et 2015. Les traumatismes iatrogenes etaient exclus de l’etude. Parmi les 1797 patients, 156 etaient âges ans et 1641 âges > 15 ans permettant de constituer nos 2 groupes. Les groupes etaient compares et analyses par les tests t de Student et Chi 2 . Resultats Une hypotension arterielle initiale etait constatee chez 6,4 % vs 14,0 % ( p = 0,006) respectivement chez l’enfant et l’adulte. Le taux de traumatismes renaux de haut grade (AAST 3, 4 et 5) et de derivation urinaire par sonde ureterale etaient similaires (53,9 vs 59,6 % ; p = 0,18) et (7,1 % vs 5,1 % ; p = 0,34), respectivement chez l’enfant et l’adulte. Aucune difference n’etait observee sur la prise en charge urologique initiale : surveillance (89,7 % vs 84,5 % ; p = 0,07), radio-embolisation (9,7 % vs 5,7 % ; p = 0,11) et chirurgical (3,8 % vs 5,1 % ; p = 0,56). Le taux de lesions viscerales associees etait similaire (44,9 % vs 47,3 % ; p = 0,62) mais les lesions osseuses augmentaient chez l’adulte (21,2 % vs 44,9 % ; p = 0,0001). Le premier lever etait plus precoce chez l’adulte (7,0 vs 6,3 jours ; p = 0,028). Aucune difference n’etait observee sur la duree d’hospitalisation (11,9 vs 15,1 jours ; p = 0,08), le nombre de deces (1,9 % vs 3,4 % ; p = 0,48) et les complications a long terme (6,8 % vs 4,1 % ; p = 0,21) respectivement chez l’enfant et l’adulte. Conclusion Bien que les adultes presentent d’avantage de polytraumatismes et d’instabilite hemodynamique au diagnostic, la population pediatrique presente le meme profil de traumatisme renal mais un premier lever plus tardif, ce qui n’entraine aucune difference sur la prise en charge urologique, ni sur la morbi-mortalite post-traumatique.
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- 2017
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31. Long-term complications after renal traumas: Results of a national multicentric study
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A. Chebbi, P. Panayatopoulos, F.X. Nouhaud, Thomas Caes, P. Patard, Alexandre Gryn, X. Rod, J. Rizk, B. Pradere, Q. Langouet, François-Xavier Madec, Charles Dariane, B. Peyronnet, R. Betari, Lucas Freton, Marina Ruggiero, C. Millet, Cedric Lebacle, Jonathan Olivier, N. Brichart, G. Fiard, A. Bohem, K. Guleryuz, Ines Dominique, S. Bergerat, L. Sabourin, X. Matillon, M. Hutin, and N. Szabla
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Long term complications ,Pediatrics ,medicine.medical_specialty ,business.industry ,Urology ,Medicine ,business - Published
- 2017
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32. Facteurs de associés au décès après traumatismes du rein : résultats de l’étude multicentrique nationale traumAFUf
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A. Bohem, N. Brichart, N. Szabla, Ines Dominique, Benoit Peyronnet, Cedric Lebacle, P. Panayatopoulos, Benjamin Pradere, T. Caes, A. Chebbi, J. Olivier, X. Matillon, R. Betari, S. Bergerat, Charles Dariane, Lucas Freton, Q. Langouet, Gaelle Fiard, François-Xavier Nouhaud, J. Rizk, M. Hutin, François-Xavier Madec, C. Millet, M. Ruggiero, L. Sabourin, Alexandre Gryn, P. Patard, X. Rod, and K. Guleryuz
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,Medicine ,business - Abstract
Objectifs Le traumatisme du rein est le traumatisme genito-urinaire le plus frequent. Les facteurs predictifs de deces apres traumatisme renal sont peu connus. La classification americaine AAST par exemple n’a pas ete reconnue comme un facteur de risque de deces dans certaines etudes. L’objectif de cette etude etait d’evaluer les facteurs associes au deces apres traumatisme du rein. Methodes Une etude multicentrique retrospective nationale (traumAFUf) a ete conduite, incluant tous les patients pris en charge pour traumatisme du rein dans 15 centres hospitaliers entre 2005 et 2015. Les parametres cliniques, d’imagerie et de prise en charge ont ete recueillis. Pour les variables quantitatives [âge, hemoglobine, tension arterielle systolique a l’arrivee (tas)] des seuils ont ete determines par analyse des courbes roc. Les facteurs associes au deces ont ete identifies par test d’independance du Chi2, puis regression logistique multivariee. Resultats Parmi une cohorte de 1799 patients ayant un traumatisme renal, 1425 avaient les donnees necessaires, 59 (4,8 %) sont decedes en lien avec le traumatisme. Les facteurs independamment associes au risque de deces apres analyse uni- et multivariee etaient une tas Tableau 1 ). Conclusion Dans cette etude multicentrique, le risque de deces apres un traumatisme renal est de moins de 5 %. Une tension arterielle initiale
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- 2018
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33. Une étude nationale des traitements conservateurs des tumeurs du greffon rénal : vers les thérapies ablatives
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L. Salomon, Y. Neuzillet, Henri Bensadoun, Stéphane Larré, M.O. Timsit, F. Gaudez, J.-M. Boutin, Nicolas Terrier, Antoine Valeri, S. Bouillet, S. Benbouzid, T. Culty, X. Matillon, N. Szabla, Xavier Tillou, F. Sallusto, Rodolphe Thuret, E. Lechevallier, J. Blanchereau, and Gregory Verhoest
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,Medicine ,business - Abstract
Objectifs Decrire les resultats des traitements ablatifs (ta) des carcinomes a cellules renales (ccr) diagnostiques sur des transplants renaux fonctionnels compares a ceux de la nephrectomie partielle (np). Methodes Etude retrospective de toutes les tumeurs des transplants renaux de 32 centres de transplantation francais entre janvier 1988 et decembre 2017. Resultats Parmi 116 ccr de novo, 62 ont eu un traitement conservateur, 48 np et 14 ta. Ces patients ont ete compares aux 54 patients traites par transplantectomie. L’âge median des transplants au diagnostic etait de 43,5 ans. Les tumeurs traitees par transplantectomie presentaient plus souvent des symptomes (douleur, fievre, hematurie) (p = 0,019). Apres np, l’histologie a montre 27 (47,5 %) carcinomes papillaires, 19 (32,2 %) carcinomes a cellules claires. La taille mediane des tumeurs traitee par np etait de 24 mm sans difference par rapport au groupe ta. Neuf patients traites par np presentaient des complications postoperatoires (21 %), dont 4 Clavien IIIb. Aucun patient traite par ta n’a eu de complications. La survie specifique etait de 100 % a 37 mois pour les 2 groupes. Conclusion La np s’est averee efficace dans le traitement de petites tumeurs de reins transplantes avec de bons resultats fonctionnels et oncologiques a long terme, y compris en evitant le retour a la dialyse. Les traitements ablatifs semblent etre une therapie alternative prometteuse avec de bons resultats chez des patients selectionnes.
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- 2018
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34. Predictive factors of emergency nephrectomy after renal trauma: A multicenter study
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Marina Ruggiero, B. Pradere, Charles Dariane, Lucas Freton, N. Szabla, Ines Dominique, N. Brichart, C. Millet, Thomas Caes, P. Patard, X. Matillon, A. Chebbi, F.X. Nouhaud, S. Bergerat, Alexandre Gryn, Paul Panayotopoulos, R. Betari, Jonathan Olivier, F-X.R. Madec, K. Guleryuz, B. Peyronnet, G. Fiard, J. Rizk, Cedric Lebacle, and L. Sabourin
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medicine.medical_specialty ,Multicenter study ,business.industry ,Urology ,medicine.medical_treatment ,medicine ,business ,Nephrectomy ,Surgery - Published
- 2018
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35. Management of renal trauma between adult and pediatric population
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J. Rizk, B. Peyronnet, Ines Dominique, R. Betari, C. Millet, A. Chebbi, X. Rod, B. Pradere, Marina Ruggiero, Charles Dariane, K. Guleryuz, Lucas Freton, A. Bohem, P.M. Patard, Thomas Caes, F-X.R. Madec, Alexandre Gryn, Cedric Lebacle, F.X. Nouhaud, S. Bergerat, G. Fiard, O. Abbo, P. Panayatopoulos, L. Sabourin, N. Szabla, and M. Hutin
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Pediatrics ,medicine.medical_specialty ,business.industry ,Urology ,Medicine ,business ,Pediatric population - Published
- 2018
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36. Early discharge in patients with low grade renal trauma: Results of the TRAUMAFUF multicentre study
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P. Patard, Ines Dominique, Thomas Caes, P. Panayatopoulos, J. Rizk, X. Rod, Q. Langouet, R. Betari, S. Bergerat, B. Peyronnet, N. Brichart, A. Chebbi, L.M. Scailteux, Cedric Lebacle, F.X. Nouhaud, X. Matillon, A. Bohem, L. Sabourin, G. Fiard, K. Guleryuz, Alexandre Gryn, Jonathan Olivier, B. Pradere, N. Szabla, Charles Dariane, Lucas Freton, François-Xavier Madec, C. Millet, Marina Ruggiero, and M. Hutin
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Pediatrics ,medicine.medical_specialty ,business.industry ,Urology ,Medicine ,In patient ,business ,Early discharge - Published
- 2018
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37. Incidence et facteur prédictifs des pseudo-anévrysmes au cours des traumatismes du rein : résultats de l’étude multicentrique nationale Traumafuf
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F.X. Nouhaud, Cedric Lebacle, G. Fiard, J. Rizk, Jonathan Olivier, M. Ruggiero, T. Caes, N. Szabla, Alexandre Gryn, K. Guleryuz, C. Millet, Karim Bensalah, R. Betari, X. Matillon, L. Sabourin, N. Brichart, François-Xavier Madec, Benjamin Pradere, S. Bergerat, B. Peyronnet, P. Patard, Ines Dominique, A. Boehm, Q. Langouet, A. Chebbi, P. Panayotopoulos, Charles Dariane, and Lucas Freton
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Le traumatisme du rein est retrouve dans pres de 10 % des traumatismes abdominaux. Les complications renales graves telles que les pseudo-anevrysmes sont redoutees mais leurs incidences sont peu connues et il n’existe, a ce jour, aucun moyen de predire leur apparition. L’objectif de cette etude etait d’evaluer l’incidence des pseudo-anevrysmes (PA) et de rechercher les facteurs de risques d’apparition de cette complication. Methodes Une etude multicentrique retrospective nationale (Traumafuf) a ete conduite, incluant tous les patients pris en charge pour traumatisme du rein dans 15 centres hospitaliers entre 2005 et 2015. Les traumatismes iatrogenes etaient exclus. Les patients presentant un PA ont ete compares aux patients sans PA. Le test du Chi 2 (ou le test de Fisher) a ete utilise pour comparer les variables qualitatives, le test t- de Student pour les variables quantitatives. Une analyse multivariee par regression logistique a ete realisee pour rechercher les facteurs predictifs d’apparition de pseudo-anevrysmes. Resultats Parmi une cohorte de 1293 patients ayant un traumatisme renal, 2,8 % ( n = 31) ce sont compliques d’un pseudo-anevrysme. L’âge moyen etait de 33 ans, 77,4 % avaient un traumatisme renal ≥ 3. La plupart de ces patients presentaient une hematurie macroscopique a leur arrivee (74 %), 36 % de ces patients avaient un saignement actif lors du TDM diagnostique et 30 % presentaient une fuite urinaire concomitante. Comparativement aux patients sans PA, ils presentaient plus souvent un saignement actif initialement ( p = 0,01) et necessitaient des traitements plus precoces ( p p = 0,04) et le sexe masculin (OR = 7 ; IC 95 % [1,5–125,9] ; p = 0,009). Conclusion Bien que le pseudo-anevrysme renal soit l’une des complications les plus dangereuses dans les suites d’un traumatisme renal, elle n’est pas frequente. Un grade eleve de traumatisme renal est un facteur predictif important d’apparition de cette complication et doit necessiter un controle TDM precoce et au moindre doute.
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- 2016
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38. Traumatismes du rein de bas grade : vers une prise en charge en ambulatoire ? Résultats de l’étude multicentrique nationale Traumafuf
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A. Chebbi, J. Rizk, T. Caes, G. Fiard, X. Matillon, Cedric Lebacle, Alexandre Gryn, M. Ruggiero, Jonathan Olivier, C. Millet, B. Peyronnet, L. Sabourin, Charles Dariane, Lucas Freton, François-Xavier Madec, S. Bergerat, Karim Bensalah, R. Betari, P. Panayatopoulos, K. Guleryuz, P. Patard, Q. Langouet, N. Szabla, Ines Dominique, F.X. Nouhaud, N. Brichart, and Benjamin Pradere
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Le traumatisme du rein est le traumatisme genito-urinaire le plus frequent. Les societes savantes recommandent une hospitalisation systematique en cas de traumatisme du rein, y compris en cas de traitement conservateur pour surveillance. Pourtant, il n’existe aucune donnee dans la litterature confirmant cette recommandation. L’objectif de cette etude etait d’evaluer la prise en charge en ambulatoire des traumatismes du rein de bas grade. Methodes Une etude multicentrique retrospective nationale (Traumafuf) a inclus tous les patients pris en charge pour traumatisme du rein dans 15 centres hospitaliers entre 2005 et 2015. Etaient exclus les traumatismes iatrogenes et les traumatismes de haut grade (grades 4 et 5 de l’AAST) et les patients ayant des lesions viscerales/osseuses associees. Les patients ont ete divises en 2 groupes : hospitalisation ≤ 24 heures (ambulatoire) et hospitalisation > 24 heures (hospitalisation). Le choix de prise en charge etait pris au cas par cas. Les facteurs predictifs de rehospitalisation, et de traitement chirurgical et/ou radio-interventionnel secondaire ont ete recherches par analyse multivariee. Resultats Parmi 1293 patients ayant un traumatisme renal, 811 patients avaient un traumatisme de bas grade (62,7 %). Trois cent soixante et un n’avaient pas de lesions viscerales/osseuses associees (27,9 %) et ont ete inclus dans l’analyse : 41 dans le groupe ambulatoire et 320 dans le groupe hospitalisation ( Tableau 1 ). L’ambulatoire n’etait pas associe a un risque augmente de nephrectomie (0 % vs 1,9 % ; p = 0,99) ni de rehospitalisation (0 % vs 4,4 % ; p = 0,61), de traitement secondaire (0 % vs 10,3 %, p = 0,23) ou de complications a long terme (4,8 % vs 4,9 % ; p = 0,98). Seul 22 patients dont le traitement initial etait conservateur ont necessite un traitement chirurgical et/ou radio-interventionnel secondaire (6,1 %). Six patients ont necessite une nephrectomie (dont 2 nephrectomies partielles). Conclusion Cette etude multicentrique demontre la faisabilite de la prise en charge en ambulatoire des traumatismes du rein de bas grade. D’autres etudes sont necessaires pour confirmer ces resultats et preciser les eventuels criteres de selection des patients eligibles a cette prise en charge.
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- 2016
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39. Facteurs de risque d’échec du traitement conservateur des traumatismes du rein : une étude multicentrique (TRAUMAFUF)
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J. Rizk, Charles Dariane, Lucas Freton, B. Peyronnet, T. Caes, Cedric Lebacle, Alexandre Gryn, X. Matillon, P. Patard, Jonathan Olivier, A. Bohem, M. Ruggiero, François-Xavier Madec, Q. Langouet, N. Szabla, S. Bergerat, X. Rod, Ines Dominique, C. Millet, F.X. Nouhaud, G. Fiard, K. Guleryuz, M. Hutin, R. Betari, A. Chebbi, L. Sabourin, N. Brichart, Benjamin Pradere, and P. Panayatopoulos
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Le traumatisme du rein est le traumatisme genito-urinaire le plus frequent, retrouve dans 10 % des traumatismes abdominaux. Les recommandations actuelles preconisent un traitement conservateur base sur une surveillance clinique et paraclinique, cependant, il existe peu de donnees bibliographiques sur les facteurs de risque d’echec du traitement conservateur. L’objectif de cette etude etait d’evaluer les facteurs de risque d’echec du traitement conservateur des fractures du rein. Methodes Une etude multicentrique retrospective nationale (TRAUMAFUF) a ete conduite, incluant tous les patients pris en charge pour traumatisme du rein dans 15 centres hospitaliers entre 2005 et 2015. Les traumatismes iatrogenes etaient exclus ainsi que les patients ayant eu un traitement non conservateur (traitement chirurgical ou radio interventionnel). L’echec du traitement conservateur etait defini par le besoin d’une prise en charge chirurgicale ou radio-interventionnelle pendant la surveillance. Des analyses multivariees ont ete realisees afin d’identifier les facteurs de risque d’echec du traitement conservateur. Resultats Sur 1799 patients avec un traumatisme renal, 1486 ont eu un traitement conservateur (82,6 %). L’echec du traitement conservateur a ete constate chez 175 patients (11,8 %). En analyse univariee, le grade AAST de la fracture du rein (p Conclusion Dans cette etude multicentrique, les seuls facteurs de risque identifies d’echec du traitement conservateur des traumatismes du rein etaient le grade AAST de la fracture du rein et la presence d’une hematurie macroscopique au moment de l’admission. Une surveillance rapprochee est donc preconisee chez ces patients pris en charge par traitement conservateur.
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- 2017
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40. Faut-il maintenir les patients en décubitus dorsal après un traumatisme du rein ? Résultats de l’étude multicentrique nationale Traumafuf
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C. Millet, Ines Dominique, Jonathan Olivier, A. Chebbi, François-Xavier Madec, S. Bergerat, P. Panayatopoulos, Karim Bensalah, N. Szabla, L. Sabourin, A. Bohem, R. Betari, Q. Langouet, Charles Dariane, Lucas Freton, Alexandre Gryn, F.X. Nouhaud, G. Fiard, M. Ruggiero, B. Peyronnet, Cedric Lebacle, N. Brichart, K. Guleryuz, Benjamin Pradere, P. Patard, T. Caes, X. Matillon, and J. Rizk
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Le traumatisme du rein est le traumatisme genito-urinaire le plus frequent, retrouve dans 10 % des cas de traumatisme abdominal. Les societes savantes recommandent le maintien en decubitus dorsal apres un traumatisme du rein. Pourtant, il n’existe aucune donnee dans la litterature en faveur de cette recommandation. L’objectif de cette etude etait d’evaluer l’impact du decubitus dorsal sur le devenir des traumatismes du rein. Methodes Une etude multicentrique retrospective nationale (Traumafuf) a ete conduite, incluant tous les patients pris en charge pour traumatisme du rein dans 15 centres hospitaliers entre 2005 et 2015. Les traumatismes iatrogenes etaient exclus de l’etude. Pour la presente analyse, les patients pour qui le jour du premier lever n’etait pas retrouve dans le dossier etaient egalement exclus. Les patients ont ete divises en 2 groupes : lever au cours des premieres 24 heures (lever precoce : LP) et premier lever > 24 heures (lever tardif : LT). Les groupes ont ete compares et des analyses multivariees ont ete realisees. Resultats Parmi une cohorte de 1284 patients, la donnee sur le jour du premier lever etait disponible pour 619 patients : 107 dans le groupe LP et 512 dans le groupe LT. Les taux de transfusion et de traitement chirurgical apres le premier lever etaient similaires dans les groupes LP et LT ( p = 0,99 et p = 0,60). En revanche la reprise du transit etait plus precoce dans le groupe LP (3,8 vs 5,9 jours ; p p p p Conclusion Dans cette etude multicentrique, le lever precoce apres traumatisme renal n’augmentait pas le risque de transfusion ni de traitement chirurgical ou radio-interventionnel secondaires et etait associe a une acceleration de la reprise du transit et a une duree d’hospitalisation plus courte.
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- 2016
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41. Complications rénales à long terme des traumatismes rénaux : résultats de l’étude multicentrique nationale Traumafuf
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J. Rizk, F.X. Nouhaud, Fabien Saint, Q. Langouet, K. Guleryuz, B. Peyronnet, François-Xavier Madec, R. Betari, Charles Dariane, Lucas Freton, Cedric Lebacle, N. Szabla, S. Bergerat, Jonathan Olivier, A. Chebbi, C. Millet, A. Ruffion, P. Panayotopoulos, M. Ruggiero, Ines Dominique, L. Sabourin, G. Fiard, P. Patard, T. Caes, X. Matillon, N. Brichart, and Benjamin Pradere
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Le traumatisme du rein est le traumatisme genito-urinaire le plus frequent, retrouve dans 10 % des cas de traumatisme abdominal. Les donnees de la litterature sur les complications renales de ces traumatismes renaux a long terme sont rares. L’objectif de cette etude etait d’evaluer les complications renales a long terme apres traumatisme du rein et d’en identifier les facteurs predictifs. Methodes Une etude multicentrique retrospective nationale (Traumafuf) a ete conduite, incluant tous les patients pris en charge pour traumatisme du rein dans 15 centres hospitaliers entre 2005 et 2015. Les traumatismes iatrogenes etaient exclus de l’etude. Pour l’analyse, les patients n’ayant pas de complications renales a long terme ainsi que les patients perdus de vue apres leur traumatisme etaient exclus de l’etude. Etait consideree comme complication a long terme toute complication attribuable au traumatisme du rein et survenant plus de 3 mois apres le traumatisme. Resultats Parmi une cohorte de 1287 patients, les donnees des complications a long terme etaient retrouvees pour 729 patients. Parmi les 729 patients analyses, 37 patients (5,1 %) ont presente une complication a long terme de leur traumatisme renal. Le delai moyen de diagnostic des complications a long terme etait de 16,23 mois. Les principales complications a long terme retrouvees et leur frequence sont presentees dans le Tableau 1 . Concernant les traitements de ces complications, 4 nephrectomies ont ete realisees, 3 embolisations pour faux-anevrysme arteriel renal, un stent ureteral et une dilatation ureterale pour stenose ureterale. Trois patients etaient sous traitement anti-HTA au long cours. Conclusion Les complications a long terme des traumatismes renaux sont rares mais doivent etre recherchees en raison de leur gravite. Les complications a long terme sont probablement sous-estimees en raison des nombreux patients perdus de vue. Une consultation de suivi urologique apres traumatisme renal devrait etre organisee systematiquement a court terme mais aussi a distance pour depister les complications tardives.
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- 2016
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42. Rôle de l’imagerie de réévaluation dans la prise en charge des traumatismes du rein : résultats de l’étude multicentrique nationale Traumafuf
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Fabien Saint, Q. Langouet, F.X. Nouhaud, T. Caes, M. Ruggiero, K. Guleryuz, P. Patard, Cedric Lebacle, X. Matillon, C. Millet, J. Rizk, Ines Dominique, François-Xavier Madec, S. Bergerat, G. Fiard, R. Betari, L. Sabourin, A. Chebbi, P. Panayatopoulos, Charles Dariane, Lucas Freton, B. Peyronnet, N. Szabla, Jonathan Olivier, N. Brichart, and Benjamin Pradere
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Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,business - Abstract
Objectifs Le traumatisme du rein est le plus frequent des traumatismes genito-urinaires. Certaines societes savantes recommandent une imagerie de reevaluation systematique 3 a 7 jours apres le traumatisme initial. Toutefois les donnees de la litterature a ce sujet sont contradictoires. L’objectif de cette etude etait d’evaluer l’impact d’une imagerie de reevaluation apres traumatisme du rein. Methodes Une etude multicentrique retrospective nationale (Traumafuf) a ete conduite, incluant tous les patients pris en charge pour traumatisme du rein dans 15 centres hospitaliers entre 2005 et 2015. Les patients etaient divises en 3 groupes : pas d’imagerie de controle (Padim), imagerie de controle systematique (patient asymptomatique, Imsyst), imagerie de controle pour symptomes (Imsympt). Les groupes etaient compares et des analyses multivariees realisees pour rechercher les facteurs predictifs de traitement secondaire, de modification de la prise en charge therapeutique et de rehospitalisation. Resultats Parmi 927 patients ayant un traumatisme renal, 758 ont eu une imagerie de reevaluation (81,8 %) : 583 a titre systematique (76,9 %) et 175 devant des symptomes (23,1 %). Le delai median de realisation de l’imagerie etait de 5 jours chez les patients symptomatiques vs 7 jours chez les asymptomatiques. Une anomalie etait diagnostiquee plus frequemment dans le groupe Imsympt vs le groupe Imsyst (57,1 % vs 24,1 % ; p p = 0,81). Conclusion Dans cette etude, l’imagerie de controle systematique dans les 10 premiers jours suivant un traumatisme du rein ne modifiait la prise en charge therapeutique que chez 5,1 % des patients asymptomatiques. L’imagerie de controle pourrait ainsi etre limitee aux patients symptomatiques, presentant un saignement actif ou une extravasation urinaire sur le scanner initial et aux patients a risque de pseudo-anevrysme.
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- 2016
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43. Evolution and development of Drosophila melanogaster under different thermal conditions affected cell sizes and sensitivity to paralyzing hypoxia.
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Szabla N, Maria Labecka A, Antoł A, Sobczyk Ł, Angilletta MJ, and Czarnoleski M
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- Animals, Wings, Animal growth & development, Temperature, Malpighian Tubules, Male, Female, Hypoxia, Drosophila melanogaster growth & development, Drosophila melanogaster physiology, Biological Evolution, Cell Size
- Abstract
Environmental gradients cause evolutionary and developmental changes in the cellular composition of organisms, but the physiological consequences of these effects are not well understood. Here, we studied experimental populations of Drosophila melanogaster that had evolved in one of three selective regimes: constant 16 °C, constant 25 °C, or intergenerational shifts between 16 °C and 25 °C. Genotypes from each population were reared at three developmental temperatures (16 °C, 20.5 °C, and 25 °C). As adults, we measured thorax length and cell sizes in the Malpighian tubules and wing epithelia of flies from each combination of evolutionary and developmental temperatures. We also exposed flies from these treatments to a short period of nearly complete oxygen deprivation to measure hypoxia tolerance. For genotypes from any selective regime, development at a higher temperature resulted in smaller flies with smaller cells, regardless of the tissue. At every developmental temperature, genotypes from the warm selective regime had smaller bodies and smaller wing cells but had larger tubule cells than did genotypes from the cold selective regime. Genotypes from the fluctuating selective regime were similar in size to those from the cold selective regime, but their cells of either tissue were the smallest among the three regimes. Evolutionary and developmental treatments interactively affected a fly's sensitivity to short-term paralyzing hypoxia. Genotypes from the cold selective regime were less sensitive to hypoxia after developing at a higher temperature. Genotypes from the other selective regimes were more sensitive to hypoxia after developing at a higher temperature. Our results show that thermal conditions can trigger evolutionary and developmental shifts in cell size, coupled with changes in body size and hypoxia tolerance. These patterns suggest links between the cellular composition of the body, levels of hypoxia within cells, and the energetic cost of tissue maintenance. However, the patterns can be only partially explained by existing theories about the role of cell size in tissue oxygenation and metabolic performance., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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44. Updated National Study of Functional Graft Renal Cell Carcinomas: Are They a Different Entity?
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Szabla N, Matillon X, Calves J, Branchereau J, Champy C, Neuzillet Y, Bessede T, Bouhié S, Boutin JM, Caillet K, Cognard N, Culty T, De Fortescu G, Drouin S, Bentellis I, Hubert J, Boissier R, Sallusto F, Sénéchal C, Terrier N, Thuret R, Verhoest G, Waeckel T, and Tillou X
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- Humans, Middle Aged, Retrospective Studies, Kidney pathology, Carcinoma, Renal Cell epidemiology, Carcinoma, Renal Cell surgery, Carcinoma, Renal Cell diagnosis, Kidney Neoplasms epidemiology, Kidney Neoplasms surgery, Kidney Neoplasms diagnosis, Kidney Transplantation adverse effects
- Abstract
Objective: To analyze de novo graft carcinoma characteristics from our updated national multicentric retrospective cohort., Methods: Thirty-two transplant centers have retrospectively completed the database. This database concerns all kidney graft tumors including urothelial, and others type but excludes renal lymphomas over 31 years., Results: One hundred and fifty twokidney graft carcinomas were diagnosed in functional grafts. Among them 130 tumors were Renal Cell Carcinomas. The calculated incidence was 0.18%. Median age of the allograft at diagnosis was 45.4 years old. The median time between transplantation and diagnosis was 147.1 months. 60 tumors were papillary carcinomas and 64 were clear cell carcinomas. Median tumor size was 25 mm. 18, 64, 21 and 1 tumors were respectively Fuhrman grade 1, 2, 3 and 4. Nephron sparing surgery (NSS) was performed on 68 (52.3%) recipients. Ablative therapy was performed in 23 cases (17.7%). Specific survival rate was 96.8%., Conclusion: This study confirmed that renal graft carcinomas are a different entity: with a younger age of diagnosis; a lower stage at diagnosis; a higher incidence of papillary subtypes., (Copyright © 2022 Elsevier Inc. All rights reserved.)
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- 2023
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45. Who Is at Risk of Death after Renal Trauma? An Analysis of Thirty-Day Mortality after 1,799 Cases of Renal Trauma.
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Baboudjian M, Lebacle C, Gondran-Tellier B, Hutin M, Olivier J, Ruggiero M, Panayotopoulos P, Dominique I, Millet C, Bergerat S, Freton L, Betari R, Matillon X, Chebbi A, Caes T, Patard PM, Szabla N, Sabourin L, Dariane C, Rizk J, Madec FX, Nouhaud FX, Rod X, Fiard G, Pradere B, and Peyronnet B
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- Humans, Adult, Retrospective Studies, Risk Factors, Arteries, Kidney, Wounds, Nonpenetrating
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Introduction: The aim of the study was to report the 30-day mortality (30DM) after renal trauma and identify the risk factors associated with death., Methods: The TRAUMAFUF project was a retrospective multi-institutional study including all patients with renal trauma admitted to 17 French hospitals between 2005 and 2015. The included population focused on patients of all age groups who underwent renal trauma during the study period. The primary outcome was death within 30 days following trauma. The multivariate logistic regression model with a stepwise backward elimination was used to identify predictive factors of 30DM., Results: Data on 1,799 renal trauma were recorded over the 10-year period. There were 59 deaths within 30 days of renal trauma, conferring a 30DM rate of 3.27%. Renal trauma was directly involved in 5 deaths (8.5% of all deaths, 0.3% of all renal trauma). Multivariate stepwise logistic regression analysis revealed that age >40 years (odds ratio [OR] 2.18; 95% confidence interval [CI]: 1.20-3.99; p = 0.01), hemodynamic instability (OR 4.67; 95% CI: 2.49-9; p < 0.001), anemia (OR 3.89; 95% CI: 1.94-8.37; p < 0.001), bilateral renal trauma (OR 6.77; 95% CI: 2.83-15.61; p < 0.001), arterial contrast extravasation (OR 2.09; 95% CI: 1.09-3.96; p = 0.02), and concomitant visceral and bone injuries (OR 6.57; 95% CI: 2.41-23.14; p < 0.001) were independent predictors of 30DM., Conclusion: Our large multi-institutional study supports that the 30DM of 3.27% after renal trauma is due to the high degree of associated injuries and was rarely a consequence of renal trauma alone. Age >40 years, hemodynamic instability, anemia, bilateral renal trauma, arterial contrast extravasation, and concomitant visceral and bone lesions were predictors of death. These results can help clinicians to identify high-risk patients., (© 2022 S. Karger AG, Basel.)
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- 2023
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46. Impact of Hospital Volume on the Outcomes of Renal Trauma Management.
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Baloche P, Szabla N, Freton L, Hutin M, Ruggiero M, Dominique I, Millet C, Bergerat S, Panayotopoulos P, Betari R, Matillon X, Chebbi A, Caes T, Patard PM, Brichart N, Sabourin L, Dariane C, Baboudjian M, Gondran-Tellier B, Lebacle C, Madec FX, Nouhaud FX, Rod X, Fiard G, Pradere B, and Peyronnet B
- Abstract
Background: Some health care systems have set up referral trauma centers to centralize expertise to improve trauma management. There is scant and controversial evidence regarding the impact of provider's volume on the outcomes of trauma management., Objective: To evaluate the impact of hospital volume on the outcomes of renal trauma management in a European health care system., Design Setting and Participants: A retrospective multicenter study, including all patients admitted for renal trauma in 17 French hospitals between 2005 and 2015, was conducted., Intervention: Nephrectomy, angioembolization, or nonoperative management., Outcome Measurements and Statistical Analysis: Four quartiles according to the caseload per year: low volume (eight or fewer per year), moderate volume (nine to 13 per year), high volume (14-25/yr), and very high volume (≥26/yr). The primary endpoint was failure of nonoperative management defined as any interventional radiology or surgical procedure needed within the first 30 d after admission., Results and Limitations: Of 1771 patients with renal trauma, 1704 were included. Nonoperative management was more prevalent in the very-high- and low-volume centers ( p = 0.02). In a univariate analysis, very high hospital volume was associated with a lower risk of nonoperative management failure than low (odds ratio [OR] = 0.54; p = 0.05) and moderate (OR = 0.48; p = 0.02) hospital volume. There were fewer nephrectomies in the high- and very-high-volume groups ( p = 0.003). In a multivariate analysis, very high volume remained associated with a lower risk of nonoperative management failure than low (OR = 0.48; p = 0.04) and moderate (OR = 0.42; p = 0.01) volume. Study limitations include all the shortcomings inherent to its retrospective multicenter design., Conclusions: In this multicenter study, management of renal trauma varied according to hospital volume. There were lower rates of nephrectomy and failure of nonoperative management in very-high-volume centers. These results raise the question of centralizing the management of renal trauma, which is currently not the case in our health care system., Patient Summary: In this study, management of renal trauma varied according to hospital volume. Very-high-volume centers had lower rates of nephrectomy and failure of nonoperative management., (© 2022 The Author(s).)
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- 2022
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47. Bumetanide lowers acute hydrocephalus in a rat model of subarachnoid hemorrhage.
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Metayer T, Orset C, Ali C, Furon J, Szabla N, Emery E, Vivien D, and Gaberel T
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- Animals, Bumetanide pharmacology, Bumetanide therapeutic use, Choroid Plexus, Rats, Rats, Wistar, Hydrocephalus drug therapy, Hydrocephalus etiology, Subarachnoid Hemorrhage complications, Subarachnoid Hemorrhage diagnostic imaging, Subarachnoid Hemorrhage drug therapy
- Abstract
Background: Subarachnoid hemorrhage (SAH) can lead to acute hydrocephalus (AH). AH pathophysiology is classically attributed to an obstruction of the arachnoid granulations by blood. Recent findings in rodents suggest that after intraventricular hemorrhage, AH is related to cerebrospinal fluid (CSF) hypersecretion by the choroid plexus (CP), as it can be reduced by intracerebroventricular (ICV) injection of bumetanide., Objective: Here, we investigated if and how CSF hypersecretion and/or CSF outflow disorders contribute to post-SAH hydrocephalus., Methods: Ninety-four Wistar rats were used. SAH was induced by the endovascular perforation technique. The presence of AH was confirmed by magnetic resonance imaging (MRI), and rats with AH were randomly assigned to 4 groups: control group, superior sagittal sinus (SSS) thrombosis to block CSF reabsorption, ICV injection of saline, and ICV injection of bumetanide to decrease CSF secretion. Clinical outcome was evaluated with a neuroscore. A second MRI was performed 24 h later to evaluate the ventricular volume., Results: Fifty percent of rats that survived SAH induction had AH. Their ventricular volume correlated well to the functional outcome after 24 h (r = 0.803). In rats with AH, 24 h later, ventricular volume remained equally increased in the absence of any further procedure. Similarly, ICV injection of saline or SSS thrombosis had no impact on the ventricular volume. However, ICV injection of bumetanide reduced AH by 35.9% (p = 0.002)., Conclusion: In rodents, post-SAH hydrocephalus is may be due to hypersecretion of CSF by the CP, as it is limited by ICV injection of bumetanide. However, we cannot exclude other mechanisms involved in post-SAH acute hydrocephalus., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
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- 2022
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48. Factors Predictive of Selective Angioembolization Failure for Moderate- to High-grade Renal Trauma: A French Multi-institutional Study.
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Baboudjian M, Gondran-Tellier B, Panayotopoulos P, Hutin M, Olivier J, Ruggiero M, Dominique I, Millet C, Bergerat S, Freton L, Betari R, Matillon X, Chebbi A, Caes T, Patard PM, Szabla N, Sabourin L, Dariane C, Lebacle C, Rizk J, Madec FX, Nouhaud FX, Rod X, Fiard G, Pradere B, and Peyronnet B
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- Humans, Kidney surgery, Nephrectomy methods, Retrospective Studies, Hematuria epidemiology, Hematuria etiology, Hematuria surgery, Wounds, Nonpenetrating
- Abstract
Background: Angiography with selective angioembolization (SAE) is safe and effective in addressing bleeding in patients with renal trauma. However, there are no validated criteria to predict SAE efficacy., Objective: To evaluate factors predictive of SAE failure after moderate- to high-grade renal trauma., Design, Setting, and Participants: TRAUMAFUF was a retrospective multi-institutional study including all patients who underwent upfront SAE for renal trauma in 17 French hospitals between 2005 and 2015., Outcome Measurements and Statistical Analysis: The primary outcome was SAE efficacy, defined as the absence of repeat SAE, salvage nephrectomy, and/or death for each patient., Results and Limitations: Out of 1770 consecutive patients with renal trauma, 170 (9.6%) with moderate- to high-grade renal trauma underwent SAE. Overall upfront SAE was successful in 131 patients (77%) and failed in 39 patients: six patients died after the embolization, ten underwent repeat SAE, 22 underwent open nephrectomy, and one underwent open surgical exploration. In multivariate logistic regression analysis, gross hematuria (odds ratio [OR] 3.16, 95% confidence interval [CI] 1.29-8.49; p=0.015), hemodynamic instability (OR 3.29, 95% CI 1.37-8.22; p=0.009), grade V trauma (OR 2.86, 95% CI 1.06-7.72; p=0.036), and urinary extravasation (OR 3.49, 95% CI 1.42-8.83; p=0.007) were predictors of SAE failure. The success rate was 64.7% (22/34) for patients with grade V trauma and 59.6% (31/52) for those with hemodynamic instability. The study was limited by its retrospective design and the lack of a control group managed with either surgery or surveillance., Conclusions: We found that gross hematuria, hemodynamic instability, grade V trauma, and urinary extravasation were significant predictors of SAE failure. However, success rates in these subgroups remained relatively high, suggesting that SAE might be appropriate for those patients as well., Patient Summary: Selective angioembolization (SAE) is a useful alternative to nephrectomy to address bleeding in patients with renal trauma. Currently, there are no validated criteria to predict SAE efficacy. We found that gross hematuria, hemodynamic instability, grade V trauma, and urinary extravasation were significant predictors of SAE failure., (Copyright © 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
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- 2022
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49. Educational program in onco-urology for young urologists: What are their needs?
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Pinar U, Freton L, Gondran-Tellier B, Vallée M, Dominique I, Felber M, Khene ZE, Fortier E, Lannes F, Michiels C, Grevez T, Szabla N, Bardet F, Kaulanjan K, Seizilles de Mazancourt E, Matillon X, and Pradere B
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- Humans, Internet, Surveys and Questionnaires, Urologists, Internship and Residency, Urology education
- Abstract
Purpose: The emergence of new communication media such as digital contents are progressively replacing more traditional medias in the field of educational programs. Our purpose was to assess urologist in training aspirations regarding urological education., Methods: Members of a national urologist in training association were sent an anonymous online questionnaire regarding their medical formation in the field of urology. Responders interest for urological sub-specialty or education support (new tools and traditional support) were evaluated through a 5-point Likert scale., Results: Overall, 109 young urologists (26%) responded to the survey. Most of the respondents worked during their training in an academic hospital (n=89, 82%). The three favorite tools for training chosen by the responders were: videos, workshop or masterclass, and podcasts (responders very interested were respectively n=64 (58.7%), n=50 (45.9%), and n=49 (45%)). E-mail newsletters were reported as the less useful educational tool by participants (n=38, 34.9%). Participants were very interested in improving their surgical skills and their radiological knowledge. Responders who were the most attracted by PCa were much more looking to improve their systemic treatment and radiological knowledges., Conclusions: Urologic-oncology was a priority regarding education for urologists in training. A majority of participants expressed a lack in their surgical education, revealing a reduced OR access and underlining utilization of new tools such as simulation. New digital contents such as social media or podcast achieved high interest for the participants, instead of more traditional media. There is a need that educational content evolve and uses new digital media., Level of Evidence: 3., (Copyright © 2021 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
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- 2021
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50. Residents and patients benefit from surgical simulation on a live porcine model, could we consider it as ethical?
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Prudhomme T, Matillon X, Dengu F, de Mazancourt E, Pinar U, Gondran-Tellier B, Freton L, Vallée M, Dominique I, Felber M, Khene ZE, Fortier E, Lannes F, Michiels C, Grevez T, Szabla N, Bardet F, Kaulanjan K, Pradère B, Deschamps JY, and Branchereau J
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- Animals, Clinical Competence, Computer Simulation, Humans, Swine, Urologists, Internship and Residency, Laparoscopy
- Abstract
Introduction: The objective was to evaluate, by self-questionnaire, the feeling of participants in surgical training sessions on a live porcine model., Methods: A computerized questionnaire (GoogleForm ©) was sent to the members of the French Association of Urologists-in-Training (AFUF) (fellows and residents). Only questionnaires from Urologists-in-training who had participated in surgical training sessions were included. The sessions consisted of performing surgeries such as laparoscopic nephrectomies or laparoscopic cystectomies., Results: Overall, 198 met the inclusion criteria. A total of 36.4% (72/198) of the participants were fellows and 63.6% (126/198) were residents. According to the participants, the main interest of sessions was to be able to train for emergency situations. A total of 79.8% (158/198) of the participants wanted surgical simulation to become compulsory. To their opinion, the main advantage of surgical simulation on a live porcine model was: technical progress in 87.4% (173/198) of cases. A total of 13.1% (26/198) of the participants found it was unethical to perform the first technical procedures on live animal models. A total of 65.7% (130/198) of the participants considered that there is currently no system of substitution., Conclusion: For the participants, surgical training on a live porcine model allows technical progress while training for serious emergency situations. Surgeons and patients could benefit from this risk-free mock surgical scenario., Level of Evidence: 3., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)
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- 2021
- Full Text
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