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1. Procedural efficacy and safety of standardized, ablation index guided fixed 50 W high‐power short‐duration pulmonary vein isolation and substrate modification using the CLOSE protocol

Author

Alexander Francke, Nadja S Taha, Frank Scharfe, Carsten Wunderlich, Steffen Schoen, and Marian Christoph

Subjects
medicine.medical_specialty, Esophageal temperature, medicine.diagnostic_test, business.industry, Esophagogastroduodenoscopy, medicine.medical_treatment, Anterior wall, Ablation, Pulmonary vein, Surgery, Treatment Outcome, Pulmonary Veins, Recurrence, Physiology (medical), Atrial Fibrillation, Catheter Ablation, medicine, Humans, Cardiology and Cardiovascular Medicine, Complication, business, Short duration, Substrate modification
Abstract

INTRODUCTION Ablation index (AI)-guided ablation according to the CLOSE protocol is very effective in terms of chronic pulmonary vein isolation (PVI). However, the optimal radiofrequency (RF) power remains controversial. Here, we thought to investigate the efficiency and safety of an AI-guided fixed circumferential 50 W high-power short-duration (HPSD) PVI using the CLOSE protocol. METHODS AND RESULTS In a single-center trial, 40 patients underwent randomized PVI using AI-guided ablation without esophageal temperature monitoring. In 20 patients a CLOSE protocol guided fixed 50 W HPSD was followed irrespective of the anatomical localization. Twenty subjects were treated according to the CLOSE protocol with standard power settings (20 W posterior and 40 W roof and anterior wall). In addition, 80 consecutive patients were treated according to the HPSD protocol to gather additional safety data. All patients underwent postprocedural esophagogastroduodenoscopy to reveal esophageal lesions (EDELs). The mean total procedural time was 80.3 ± 22.5 in HPSD compared to control 109.1 ± 27.4 min (p

Published
2021

2. Procedural efficacy and safety of standardized, Ablation Index guided fixed 50W high power short duration pulmonary vein isolation and substrate modification using the CLOSE protocol

Author

Steffen Schoen, Marian Christoph, Alexander Francke, Nadja S Taha, Frank Scharfe, and Carsten Wunderlich

Subjects
Temperature monitoring, business.industry, medicine.medical_treatment, medicine, Anterior wall, Nuclear medicine, business, Ablation, Atrial wall, Complication, Short duration, Substrate modification, Pulmonary vein
Abstract

Introduction: Ablation Index guided ablation according to the CLOSE protocol is very effective in terms of chronic pulmonary vein isolation (PVI). However, the optimal RF power remains controversial. Here, we thought to investigate the efficiency and safety of an AI guided fixed circumferential 50W high power short duration (HPSD) PVI using the CLOSE protocol Methods and results: In a single-centre prospective “proof of concept” trial 40 patients underwent randomized PVI using AI guided RF ablation without oesophageal temperature monitoring. In 20 patient fixed 50W HPSD was used irrespective to the anatomical localization. 20 subjects were ablated with standard power settings (20W posterior and 40W roof and anterior wall). Additionally, 80 consecutive patients were treated according to the HPSD protocol to gather additional safety data. All patients underwent post-procedural oesophago-gastro-duodenoscopy to reveal oesophageal lesions (EDEL). The mean total procedural time was 80.3±22.5 minutes in HPSD compared to control 109.1±27.4 (p

Published
2021

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