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17. Characterization of a Ligilactobacillus salivarius Strain Isolated from a Cheese Seal Which Was Last Used in 1936.

Author

Alba, Claudio, Arroyo, Rebeca, Fernández, Leónides, Narbad, Arjan, and Rodríguez, Juan M.

Subjects
LACTIC acid bacteria, DAIRY microbiology, CHEESEMAKING, BACILLUS licheniformis, CHEESE, PEPTIDES, BACTERIAL cells, CASEINS
Abstract

Cheesemaking played a pivotal role in the life of the Pyrenean villages where cheese was a most prized commodity and the subject of much local competition. In one of them (Sasa de Sobrepuerto), Mrs. Sebastiana Palacio decided in 1877 to label all the cheeses made in her household with a seal to differentiate them from those made by other local producers. The cheese seal was last used in 1936 and, since then, it has been kept under excellent storage conditions. Since well-preserved cheese seals are rare, and bacterial cells may survive desiccation for long periods, the objective of this work was to isolate and characterize any lactic acid bacteria that survived in the seal. Analysis of the milky crust material revealed the presence of sheep caseins. Culture-based analysis led to the isolation of a strain of Bacillus licheniformis and a strain of Ligilactobacillus salivarius (L. salivarius SP36). The latter was characterized in vitro for safety and dairy-related functional properties. Its genome encodes several genes involved in protein, peptide, and amino acid catabolism, and flavor. Overall, the phenotypic and genetic features of this strain support a high potential for being used as adjunct culture in cheesemaking. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination

Author

Erickson, Andrea K, Jesudhasan, Palmy R, Mayer, Melinda J, Narbad, Arjan, Winter, Sebastian E, and Pfeiffer, Julie K

Subjects
Microbiology, Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Vaccine Related, Digestive Diseases, Prevention, Biodefense, Infectious Diseases, Genetics, Emerging Infectious Diseases, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Animals, Bacteria, Cell Line, Tumor, Coinfection, Enterovirus Infections, HeLa Cells, Humans, Male, Mice, Mice, Inbred C57BL, Poliovirus, Recombination, Genetic, Hela Cells, bacteria, co-infection, enteric virus, evolution, fitness, microbiota, poliovirus, recombination, Immunology, Biochemistry and cell biology, Medical microbiology
Abstract

RNA viruses exist in genetically diverse populations due to high levels of mutations, many of which reduce viral fitness. Interestingly, intestinal bacteria can promote infection of several mammalian enteric RNA viruses, but the mechanisms and consequences are unclear. We screened a panel of 41 bacterial strains as a platform to determine how different bacteria impact infection of poliovirus, a model enteric virus. Most bacterial strains, including those extracted from cecal contents of mice, bound poliovirus, with each bacterium binding multiple virions. Certain bacterial strains increased viral co-infection of mammalian cells even at a low virus-to-host cell ratio. Bacteria-mediated viral co-infection correlated with bacterial adherence to cells. Importantly, bacterial strains that induced viral co-infection facilitated genetic recombination between two different viruses, thereby removing deleterious mutations and restoring viral fitness. Thus, bacteria-virus interactions may increase viral fitness through viral recombination at initial sites of infection, potentially limiting abortive infections.

Published
2018

33. A natural mutation in Pisum sativum L. (pea) alters starch assembly and improves glucose homeostasis in humans

Author

Petropoulou, Katerina, Salt, Louise J., Edwards, Cathrina H., Warren, Frederick J., Garcia-Perez, Isabel, Chambers, Edward S., Alshaalan, Rasha, Khatib, Mai, Perez-Moral, Natalia, Cross, Kathryn L., Kellingray, Lee, Stanley, Rachael, Koev, Todor, Khimyak, Yaroslav Z., Narbad, Arjan, Penney, Nicholas, Serrano-Contreras, Jose Ivan, Charalambides, Maria N., Miguens Blanco, Jesus, Castro Seoane, Rocio, McDonald, Julie A. K., Marchesi, Julian R., Holmes, Elaine, Godsland, Ian F., Morrison, Douglas J., Preston, Tom, Domoney, Claire, Wilde, Peter J., and Frost, Gary S.

Published
2020
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43. Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

Author

D’Amato, Alfonsina, Di Cesare Mannelli, Lorenzo, Lucarini, Elena, Man, Angela L., Le Gall, Gwenaelle, Branca, Jacopo J. V., Ghelardini, Carla, Amedei, Amedeo, Bertelli, Eugenio, Regoli, Mari, Pacini, Alessandra, Luciani, Giulia, Gallina, Pasquale, Altera, Annalisa, Narbad, Arjan, Gulisano, Massimo, Hoyles, Lesley, Vauzour, David, and Nicoletti, Claudio

Published
2020
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