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722 results on '"National Key R'

1. Efavirenz 400mg in Treatment-naïve Chinese HIV-infected Patients

Author: National Key Technologies R&D Program for the 13th Five-year Plan, National Key Technologies R&D Program for the 12th Five-year Plan, CAMS Initiative for Innovative Medicine, and LI Taisheng, Director in department of Infectious Diseases
Published: 2020

2. Chinese Expert Consensus Statement on Clinical Evaluation System of Medical Endoscopy

Author: Chinese Medical Doctors Association of Thoracic Surgeons, Thoracic Surgery Branch of Zhejiang Medical Association, Chinese Thoracic Surgery Lung Cancer Union, and The National Key R&D Program of China
Subjects: medical endoscopy, evaluation index, expert consensus, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Nowadays, there is a rising development and popularity of medical endoscopes. The international brand dominates the endoscope market. The market size of domestic brands is also growing rapidly. The electronic technologies of hard or soft endoscopes are developing rapidly and gradually approaching to the advanced level in worldwide. However, at present, there is a lack of relevant standards for national standards and industry regulations for evaluating medical endoscopes, and also lacking of quantitative and clear understanding of the gap between domestic and foreign products. It is urgently necessary to give a comprehensive and accurate evaluation to the medical endoscopes. In this context, the expert group has established a scientific, systematic, and applicable standardized medical endoscopy clinical evaluation system to standardize various endoscopic evaluation indicators.
Published: 2020
Full Text: View/download PDF

3. Editorial: Community Series-extremophiles: Microbial Genomics and Taxogenomics, volume II

Author: Universidad de Sevilla. Departamento de Microbiología y Parasitología, National Key R&D Program of China, Macau University of Science and Technology, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Antunes, André, Ruiz de la Haba, Rafael, Jebbar, Mohamed, Hedlund, Brian P., Universidad de Sevilla. Departamento de Microbiología y Parasitología, National Key R&D Program of China, Macau University of Science and Technology, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, Antunes, André, Ruiz de la Haba, Rafael, Jebbar, Mohamed, and Hedlund, Brian P.
Published: 2024

4. Boosting Low-Temperature CO2 Hydrogenation over Ni-based Catalysts by Tuning Strong Metal-Support Interactions.

Author: Universidad de Sevilla. Departamento de Química Inorgánica, National Natural Science Foundation of China (NSFC), Natural Science Foundation of Liaoning Province, Natural Science Foundation of Shanxi Province for Distinguished Young Scholar, Natural Science Foundation of Jiangxi Province for Distinguished Young Scholars, Thousand Talents Plan of Jiangxi Province, Natural Science Foundation of Chongqing, European Commission through the BIOALL project, National Key R&D Program of China, Ye, Runping, Ma, Lixuan, Hong, Xiaoling, Ramírez Reina, Tomás, Luo, Wenhao, Kang, Liqun, Liu, Jian, Universidad de Sevilla. Departamento de Química Inorgánica, National Natural Science Foundation of China (NSFC), Natural Science Foundation of Liaoning Province, Natural Science Foundation of Shanxi Province for Distinguished Young Scholar, Natural Science Foundation of Jiangxi Province for Distinguished Young Scholars, Thousand Talents Plan of Jiangxi Province, Natural Science Foundation of Chongqing, European Commission through the BIOALL project, National Key R&D Program of China, Ye, Runping, Ma, Lixuan, Hong, Xiaoling, Ramírez Reina, Tomás, Luo, Wenhao, Kang, Liqun, and Liu, Jian
Abstract: Rational design of low-cost and efficient transition-metal catalysts for low-temperature CO2 activation is significant and poses great challenges. Herein, a strategy via regulating the local electron density of active sites is developed to boost CO2 methanation that normally requires >350 °C for commercial Ni catalysts. An optimal Ni/ZrO2 catalyst affords an excellent low-temperature performance hitherto, with a CO2 conversion of 84.0 %, CH4 selectivity of 98.6 % even at 230 °C and GHSV of 12,000 mL g−1 h−1 for 106 h, reflecting one of the best CO2 methanation performance to date on Ni-based catalysts. Combined a series of in situ spectroscopic characterization studies reveal that re-constructing monoclinic-ZrO2 supported Ni species with abundant oxygen vacancies can facilitate CO2 activation, owing to the enhanced local electron density of Ni induced by the strong metal-support interactions. These findings might be of great aid for construction of robust catalysts with an enhanced performance for CO2 emission abatement and beyond.
Published: 2023

5. Breakup of the proton halo nucleus 8B near barrier energies

Author: Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, National Key R&D Program of China, National Natural Science Foundation of China, Continuous Basic Scientific Research, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, Korea government (MSIT), Yang, Lin, Lin, C. J., Yamaguchi, H., Moro Muñoz, Antonio Matías, Ma, N. R., Wang, D. X., Cook, K. J., Mazzocco, M., Zhong, F. P., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, National Key R&D Program of China, National Natural Science Foundation of China, Continuous Basic Scientific Research, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, Korea government (MSIT), Yang, Lin, Lin, C. J., Yamaguchi, H., Moro Muñoz, Antonio Matías, Ma, N. R., Wang, D. X., Cook, K. J., Mazzocco, M., and Zhong, F. P.
Abstract: The dynamics of a nuclear open quantum system could be revealed in the correlations between the breakup fragments of halo nuclei. The breakup mechanism of a proton halo nuclear system is of particular interest as the Coulomb polarization may play an important role, which, however, remains an open question. Here we use a highly efficient silicon detector array and measure the correlations between the breakup fragments of 8B incident on 120Sn at near-barrier energies. The energy and angular correlations can be explained by a fully quantum mechanical method based on the state-of-the-art continuum discretized coupled channel calculations. The results indicate that, compared to the neutron halo nucleus 6He, 8B presents distinctive reaction dynamics: the dominance of the elastic breakup. This breakup occurs mainly via the short-lived continuum states, almost exhausts the 7Be yield, indicating the effect of Coulomb polarization on the proton halo state. The correlation information reveals that the prompt breakup mechanism dominates, occurring predominantly on the outgoing trajectory. We also show that, as a large environment, the continuum of 8B breakup may not significantly influence elastic scattering and complete fusion.
Published: 2022

6. A High-Gain Observer-Based Adaptive Super-Twisting Algorithm for DC-Link Voltage Control of NPC Converters

Author: Universidad de Sevilla. Departamento de Ingeniería Electrónica, National Key R&D Program of China, National Natural Science Foundation of China, Self-Planned Task of State Key Laboratory of Robotics and System (HIT), Ministerio de Economía y Competitividad (MINECO). España, Junta de Andalucía, Fondo de Investigación Nacional de Qatar, Shen, Xiaoning, Liu, Jianxing, Márquez Alcaide, Abraham, Luo, Wensheng, León Galván, José Ignacio, Vázquez Pérez, Sergio, García Franquelo, Leopoldo, Universidad de Sevilla. Departamento de Ingeniería Electrónica, National Key R&D Program of China, National Natural Science Foundation of China, Self-Planned Task of State Key Laboratory of Robotics and System (HIT), Ministerio de Economía y Competitividad (MINECO). España, Junta de Andalucía, Fondo de Investigación Nacional de Qatar, Shen, Xiaoning, Liu, Jianxing, Márquez Alcaide, Abraham, Luo, Wensheng, León Galván, José Ignacio, Vázquez Pérez, Sergio, and García Franquelo, Leopoldo
Abstract: Acting as an interface between the grid and many energy systems, the active front-end (AFE) has been widely used in a large variety of industrial applications. In this paper, in order to ensure the fast dynamic performance and good disturbance rejection ability of the AFE, a high-gain observer (HGO) plus adaptive super-twisting algorithm (STA) for the three-level neutral-point-clamped (NPC) converter is proposed. Comparing with the conventional PI control strategy, the proposed controller implements the adaptive STA in the voltage regulator to provide a faster transient response. The gains of the adaptive STA keep varying according to the rules being reduced in steady state but increasing in transient conditions. Therefore, the chattering phenomenon is mitigated and the dynamic response is guaranteed. Additionally, to undermine the impact of external disturbances on the dc-link voltage, a high-efficiency HGO is designed in the voltage regulation loop to reject it. Experimental results based on a three-level NPC prototype are given and compared with the conventional PI method to validate the fast dynamic performance and high disturbance rejection ability of the proposed approach.
Published: 2020

7. Synthesis of stable W/O microemulsions of a hybrid grafted copolymer using a new inorganic cationic backbone within a unique “polyhedral cell”.

Author: Zheng QiFoundation: National Key Technology R&D Program (2006BAC19B04). and Peishi Qi
Subjects: *GRAFT copolymers, *EMULSIONS, *POLYHEDRA, *POLYMERIZATION, *TUNGSTEN, *ACRYLAMIDE, *X-ray diffraction
Abstract: A novel graft copolymerization on an inorganic cationic backbone processing within polyhedral cell(s) (PHC) is discussed. This procedure can produce stabilized W/O (water in oil) PHC microemulsions of hybrid grafted acrylic type copolymers. Three water-soluble monomers acrylamide, sodium acrylate and dimethyldiallylammonium chloride were examined and all were proved to be successful. MgAl-LDH3 (MgAl-layered double hydroxide with Mg/Al = 3), an electropositive colloid, was first applied as an inorganic backbone for hybrid graft polymerization in this study. MgAl-LDH3 not only acted as a cationic functional backbone, but also stabilized the PHC system due to the electropositive repulsion force. The polymerization occurring within the PHC system could reduce the oil phase percentage of the emulsion, which potentially increases the stability of the final product. The polymerization was initiated by the backbone/ceric sulfate redox system and a variety of hybrid graft copolymers with MgAl-LDH3 as the backbone chain was synthesized. The influence of [monomer] and [MgAl-LDH3][Ce4+] were examined based on the obtained reaction kinetic data. The percentages of PHC under different Fdwere determined by microscopy and the backbone structure was characterized by X-ray diffraction (XRD). [ABSTRACT FROM AUTHOR]
Published: 2009
Full Text: View/download PDF

8. A self-supported high-entropy metallic glass with a nanosponge architecture for efficient hydrogen evolution under alkaline and acidic conditions

Author: National Key R&D Program of China Major Program of national Natural Science Foundation of China Hong Kong Innovation and Technology Commission Hong Kong Branch of National Precious Metals Material Engineering Research Centre Australian Research Council UNSW Faculty Funded Postdoctoral Research Fellowship, Jia, Zhe, Nomoto, Keita, Wang, Qing, Kong, Charlie, Sun, Ligang, Zhang, Lai-Chang, Liang, Shun-Xing, Lu, Jian, Kruzic, Jamie J., National Key R&D Program of China Major Program of national Natural Science Foundation of China Hong Kong Innovation and Technology Commission Hong Kong Branch of National Precious Metals Material Engineering Research Centre Australian Research Council UNSW Faculty Funded Postdoctoral Research Fellowship, Jia, Zhe, Nomoto, Keita, Wang, Qing, Kong, Charlie, Sun, Ligang, Zhang, Lai-Chang, Liang, Shun-Xing, Lu, Jian, and Kruzic, Jamie J.
Abstract: Jia, Z., Nomoto, K., Wang, Q., Kong, C., Sun, L., Zhang, L. C., . . . Kruzic, J. J. (2021). A self-supported high-entropy metallic glass with a nanosponge architecture for efficient hydrogen evolution under alkaline and acidic conditions. Advanced Functional Materials, 31(38), article 2101586. https://doi.org/10.1002/adfm.202101586

9. Modeling biohydrogen production using different data driven approaches

Author: Provincial Key Laboratory Programme Ningbo Commonweal fund University of Nottingham UNNC FoSE New Researchers Grant Qianjiang Talent Scheme National Key R&D Program of China, Wang, Yixiao, Tang, Mingzhu, Ling, Jiangang, Wang, Yunshan, Liu, Yiyang, Jin, Huan, He, Jun, Sun, Yong, Provincial Key Laboratory Programme Ningbo Commonweal fund University of Nottingham UNNC FoSE New Researchers Grant Qianjiang Talent Scheme National Key R&D Program of China, Wang, Yixiao, Tang, Mingzhu, Ling, Jiangang, Wang, Yunshan, Liu, Yiyang, Jin, Huan, He, Jun, and Sun, Yong
Abstract: Wang, Y., Tang, M., Ling, J., Wang, Y., Liu, Y., Jin, H., . . . Sun, Y. (2021). Modeling biohydrogen production using different data driven approaches. International Journal of Hydrogen Energy, 46(58), 29822-29833. https://doi.org/10.1016/j.ijhydene.2021.06.122

10. Optimization of dark fermentation for biohydrogen production using a hybrid artificial neural network (ANN) and response surface methodology (RSM) approach

Author: National Key R&D Program of China The Faculty Inspiration Grant of University of Nottingham Qianjiang Talent Scheme-Grant, Wang, Yunshan, Yang, Gang, Sage, Valérie, Xu, Jian, Sun, Guangzhi, He, Jun, Sun, Yong, National Key R&D Program of China The Faculty Inspiration Grant of University of Nottingham Qianjiang Talent Scheme-Grant, Wang, Yunshan, Yang, Gang, Sage, Valérie, Xu, Jian, Sun, Guangzhi, He, Jun, and Sun, Yong
Abstract: Wang, Y., Yang, G., Sage, V., Xu, J., Sun, G., He, J., & Sun, Y. (2021). Optimization of dark fermentation for biohydrogen production using a hybrid artificial neural network (ANN) and response surface methodology (RSM) approach. Environmental Progress & Sustainable Energy, 40(1), article e13485. https://doi.org/10.1002/ep.13485

11. Prevention of dementia using mobile phone applications (PRODEMOS): Protocol for an international randomised controlled trial

Author: European Union's Horizon 2020 Research and Innovation Programme National Key R&D Programme of China, Eggink, Esmé, Hafdi, Melanie, Hoevenaar-Blom, Marieke P., Song, Manshu, Andrieu, Sandrine, Barnes, Linda E., Birck, Cindy, Brooks, Rachael L., Coley, Nicola, Ford, Elizabeth, Georges, Jean, van der Groep, Abraham, Van Gool, Willem A., Handels, Ron, Hou, Haifeng, Li, Dong, Liu, Hongmei, Lyu, Jihui, van Marwijk, Harm, van der Meijden, Mark, Niu, Yixuan, Sadhwani, Shanu, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Ye, Xiaoyan, Yu, Yueyi, Zeng, Qiang, Wang, Wei, Brayne, Carol, Moll van Charante, Eric P., Richard, Edo, European Union's Horizon 2020 Research and Innovation Programme National Key R&D Programme of China, Eggink, Esmé, Hafdi, Melanie, Hoevenaar-Blom, Marieke P., Song, Manshu, Andrieu, Sandrine, Barnes, Linda E., Birck, Cindy, Brooks, Rachael L., Coley, Nicola, Ford, Elizabeth, Georges, Jean, van der Groep, Abraham, Van Gool, Willem A., Handels, Ron, Hou, Haifeng, Li, Dong, Liu, Hongmei, Lyu, Jihui, van Marwijk, Harm, van der Meijden, Mark, Niu, Yixuan, Sadhwani, Shanu, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Ye, Xiaoyan, Yu, Yueyi, Zeng, Qiang, Wang, Wei, Brayne, Carol, Moll van Charante, Eric P., and Richard, Edo
Abstract: Eggink, E., Hafdi, M., Hoevenaar-Blom, M. P., Song, M., Andrieu, S., Barnes, L. E., … Richard, E. (2021). Prevention of dementia using mobile phone applications (PRODEMOS): Protocol for an international randomised controlled trial. BMJ Open, 11(6), article e049762. https://doi.org/10.1136/bmjopen-2021-049762

12. Variation of IgG N-linked glycosylation profile in diabetic retinopathy

Author: Natural Science Fund of China National Key R&D Program of China, Wu, Zhiyuan, Pan, Huiying, Liu, Di, Zhou, Di, Tao, Lixin, Zhang, Jie, Wang, Xiaonan, Li, Xia, Wang, Youxin, Wang, Wei, Guo, Xiuhua, Natural Science Fund of China National Key R&D Program of China, Wu, Zhiyuan, Pan, Huiying, Liu, Di, Zhou, Di, Tao, Lixin, Zhang, Jie, Wang, Xiaonan, Li, Xia, Wang, Youxin, Wang, Wei, and Guo, Xiuhua
Abstract: This is an author's accepted manuscript of: Wu, Z., Pan, H., Liu, D., Zhou, D., Li, H., Tao, L., ... Guo, X. (2021). Variation of IgG N-linked glycosylation profile in diabetic retinopathy. Journal of Diabetes, 13(8), 672-680. https://doi.org/10.1111/1753-0407.13160

13. Application of biochar derived from pyrolysis of waste fiberboard on tetracycline adsorption in aqueous solution

Author: National Natural Science Foundation of China National Key R&D Program of China Scientific Research on Nanjing Forestry University, Xu, Deliang, Gao, Yaxuan, Lin, Zixiang, Gao, Wenran, Zhang, Hong, Karnowo, Karnowo, Hu, Xun, Sun, Hongqi, Syed-Hassan, Syed S. A., Zhang, Shu, National Natural Science Foundation of China National Key R&D Program of China Scientific Research on Nanjing Forestry University, Xu, Deliang, Gao, Yaxuan, Lin, Zixiang, Gao, Wenran, Zhang, Hong, Karnowo, Karnowo, Hu, Xun, Sun, Hongqi, Syed-Hassan, Syed S. A., and Zhang, Shu
Abstract: Xu, D., Gao, Y., Lin, Z., Gao, W., Zhang, H., Karnowo, K., ... Zhang, S. (2020). Application of biochar derived from pyrolysis of waste fiberboard on tetracycline adsorption in aqueous solution. Frontiers in Chemistry, 7, article 943. https://doi.org/10.3389/fchem.2019.00943

14. Preparation of biochar catalyst from black liquor by spray drying and fluidized bed carbonation for biodiesel synthesis

Author: National Key R&D Program of China Faculty Inspiration Grant UNNC Qianjiang Talent Scheme Ningbo Innovation Team Project Ningbo Commonweal Key Project, Wang, Yunshan, Yang, Gang, He, Jun, Sun, Guangzhi, Sun, Zhi, Sun, Yong, National Key R&D Program of China Faculty Inspiration Grant UNNC Qianjiang Talent Scheme Ningbo Innovation Team Project Ningbo Commonweal Key Project, Wang, Yunshan, Yang, Gang, He, Jun, Sun, Guangzhi, Sun, Zhi, and Sun, Yong
Abstract: Wang, Y., Yang, G., He, J., Sun, G., Sun, Z., & Sun, Y. (2020). Preparation of biochar catalyst from black liquor by spray drying and fluidized bed carbonation for biodiesel synthesis. Process Safety and Environmental Protection, 141, 333-343. https://doi.org/10.1016/j.psep.2020.04.050

15. Association of dementia with immunoglobulin G N-glycans in a Chinese Han population

Author: National Key R&D Program of China European Commission Horizon 2020 National Natural Science Foundation of China China-Australian Collaborative Grant, Zhang, Xiaoyu, Yuan, Hui, Lyu, Jihui, Meng, Xiaoni, Tian, Qiuyue, Li, Yuejin, Zhang, Jie, Xu, Xizhu, Su, Jing, Hou, Haifeng, Li, Dong, Sun, Baoliang, Wang, Wei, Wang, Youxin, National Key R&D Program of China European Commission Horizon 2020 National Natural Science Foundation of China China-Australian Collaborative Grant, Zhang, Xiaoyu, Yuan, Hui, Lyu, Jihui, Meng, Xiaoni, Tian, Qiuyue, Li, Yuejin, Zhang, Jie, Xu, Xizhu, Su, Jing, Hou, Haifeng, Li, Dong, Sun, Baoliang, Wang, Wei, and Wang, Youxin
Abstract: Zhang, X., Yuan, H., Lyu, J., Meng, X., Tian, Q., Li, Y., ... Wang, Y. (2021). Association of dementia with immunoglobulin GN-glycans in a Chinese Han population. NPJ Aging and Mechanisms of Disease, 7, article 3. https://doi.org/10.1038/s41514-021-00055-w

16. Mobile fog computing security: A user-oriented smart attack defense strategy based on DQL

Author: The China National Key R&D Program National Natural Science Foundation of China Beijing Municipal Natural Science Foundation Scientific Research Common Program of Beijing Municipal Educations Commission Defense Industrial Technology Development Program, Tu, Shanshan, Waqas, Muhammad, Meng, Yuan, Rehman, Sadaqat Ur, Ahmad, Iftekhar, Koubaa, Anis, Halim, Zahid, Hanif, Muhammad, Chang, Chin-Chen, Shi, Chengjie, The China National Key R&D Program National Natural Science Foundation of China Beijing Municipal Natural Science Foundation Scientific Research Common Program of Beijing Municipal Educations Commission Defense Industrial Technology Development Program, Tu, Shanshan, Waqas, Muhammad, Meng, Yuan, Rehman, Sadaqat Ur, Ahmad, Iftekhar, Koubaa, Anis, Halim, Zahid, Hanif, Muhammad, Chang, Chin-Chen, and Shi, Chengjie
Abstract: Tu, S., Waqas, M., Meng, Y., Rehman, S. U., Ahmad, I., Koubaa, A., ... & Shi, C. (2020). Mobile fog computing security: A user-oriented smart attack defense strategy based on DQL. Computer Communications, 160, 790-798. https://doi.org/10.1016/j.comcom.2020.06.019

17. Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis

Author: The study was supported by grants from the National Key R&D Program of China (2017YFE0118800)—European Commission Horizon 2020 (779238-PRODEMOS), the National Natural Science Foundation of China (81872682 and 81773527), and the China-Australian Collaborative Grant (NSFC 81561128020-NHMRC APP1112767)., Zhang, Xiaoyu, Tian, Qiuyue, Liu, Di, Geng, Tao, Xu, Xizhu, Ge, Siqi, Zheng, Deqiang, Wu, Lijuan, Song, Manshu, Hou, Haifeng, Wang, Wei, Wang, Youxin, The study was supported by grants from the National Key R&D Program of China (2017YFE0118800)—European Commission Horizon 2020 (779238-PRODEMOS), the National Natural Science Foundation of China (81872682 and 81773527), and the China-Australian Collaborative Grant (NSFC 81561128020-NHMRC APP1112767)., Zhang, Xiaoyu, Tian, Qiuyue, Liu, Di, Geng, Tao, Xu, Xizhu, Ge, Siqi, Zheng, Deqiang, Wu, Lijuan, Song, Manshu, Hou, Haifeng, Wang, Wei, and Wang, Youxin
Abstract: Zhang, X., Tian, Q., Liu, D., Geng, T., Xu, X., Ge, S., ... & Wang, W. (2020). Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis. Translational Psychiatry, 10(1), 1-8. https://doi.org/10.1038/s41398-020-0822-x

18. Multi-hole simultaneous drilling of aluminium alloy: A preliminary study and evaluation against one-shot drilling process

Author: China’s National Key R&D Program (No. 2018YFB0803600), National Natural Science Foundation of China (No. 61801008), Beijing Natural Science Foundation National (No. L172049), Scientific Research Common Program of Beijing Municipal Commission of Education (No. KM201910005025) sponsored this research in part., Aamir, Muhammad, Tu, Shanshan, Giasin, Khaled, Tolouei-Rad, Majid, China’s National Key R&D Program (No. 2018YFB0803600), National Natural Science Foundation of China (No. 61801008), Beijing Natural Science Foundation National (No. L172049), Scientific Research Common Program of Beijing Municipal Commission of Education (No. KM201910005025) sponsored this research in part., Aamir, Muhammad, Tu, Shanshan, Giasin, Khaled, and Tolouei-Rad, Majid
Abstract: Aamir, M., Tu, S., Giasin, K., & Tolouei-Rad, M. (2020). Multi-hole simultaneous drilling of aluminium alloy: A preliminary study and evaluation against one-shot drilling process. Journal of Materials Research and Technology, 9(3). pp 3994-4006. https://doi.org/10.1016/j.jmrt.2020.02.026

19. Hyperuricemia is associated with immunoglobulin G N-glycosylation: A community-based study of glycan biomarkers

Author: National Health and Medical Research Council (NHMRC). National Natural Science Foundation of China. National Key R&D Program of China. European Commission Horizon 2020. Science and Technology Development Project in Taian., Hou, Haifeng, Xu, Xizhu, Sun, Fengjing, Zhang, Xiaoyu, Dong, Hualei, Wang, Liang, Ge, Siqi, An, Kang, Sun, Qi, Li, Yuejin, Cao, Weijie, Song, Manshu, Hu, Shuangjie, Xing, Weijia, Wang, Wei, Li, Dong, Wang, Youxin, National Health and Medical Research Council (NHMRC). National Natural Science Foundation of China. National Key R&D Program of China. European Commission Horizon 2020. Science and Technology Development Project in Taian., Hou, Haifeng, Xu, Xizhu, Sun, Fengjing, Zhang, Xiaoyu, Dong, Hualei, Wang, Liang, Ge, Siqi, An, Kang, Sun, Qi, Li, Yuejin, Cao, Weijie, Song, Manshu, Hu, Shuangjie, Xing, Weijia, Wang, Wei, Li, Dong, and Wang, Youxin
Abstract: Hou, H., Xu, X., Sun, F., Zhang, X., Dong, H., Wang, L., ... Wang, Y. (2019). Hyperuricemia is associated with immunoglobulin G N-glycosylation: A community-based study of glycan biomarkers. Omics: A Journal of Integrative Biology, 23(12), 660-667. Available here

20. Evolution of grain boundary and texture in TC11 titanium alloy under electroshock treatment

Author: National Key R & D Program of China (No. 2020YFA0714900), National Natural Science Foundation of China (Grant No. 51975441, No. 51901165), Application Foundation Frontier Project of Wuhan, Hubei, China (No. 2020010601012171), “Chu Tian Scholar” project of Hubei Province, China (CTXZ2017-05), Overseas Expertise Introduction Project for Discipline Innovation, China (B17034) Innovative Research Team Development Program of Ministry of Education, China (IRT_17R83), Fundamental Research Funds for the Center Universities (WUT: 2021III026JC, 2020IVB022), State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology., Liu, Chang, Yin, Fei, Xie, Lechun, Qian, Dongsheng, Song, Yanli, Wu, Wenlin, Wang, Liqiang, Zhang, Lai Chang, Hua, Lin, National Key R & D Program of China (No. 2020YFA0714900), National Natural Science Foundation of China (Grant No. 51975441, No. 51901165), Application Foundation Frontier Project of Wuhan, Hubei, China (No. 2020010601012171), “Chu Tian Scholar” project of Hubei Province, China (CTXZ2017-05), Overseas Expertise Introduction Project for Discipline Innovation, China (B17034) Innovative Research Team Development Program of Ministry of Education, China (IRT_17R83), Fundamental Research Funds for the Center Universities (WUT: 2021III026JC, 2020IVB022), State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology., Liu, Chang, Yin, Fei, Xie, Lechun, Qian, Dongsheng, Song, Yanli, Wu, Wenlin, Wang, Liqiang, Zhang, Lai Chang, and Hua, Lin
Abstract: Liu, C., Yin, F., Xie, L., Qian, D., Song, Y., Wu, W., ... & Hua, L. (2022). Evolution of grain boundary and texture in TC11 titanium alloy under electroshock treatment. Journal of Alloys and Compounds, 904, 163969. https://doi.org/10.1016/j.jallcom.2022.163969

21. Evolution of grain boundary and texture in TC11 titanium alloy under electroshock treatment

Author: National Key R & D Program of China (No. 2020YFA0714900), National Natural Science Foundation of China (Grant No. 51975441, No. 51901165), Application Foundation Frontier Project of Wuhan, Hubei, China (No. 2020010601012171), “Chu Tian Scholar” project of Hubei Province, China (CTXZ2017-05), Overseas Expertise Introduction Project for Discipline Innovation, China (B17034) Innovative Research Team Development Program of Ministry of Education, China (IRT_17R83), Fundamental Research Funds for the Center Universities (WUT: 2021III026JC, 2020IVB022), State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology., Liu, Chang, Yin, Fei, Xie, Lechun, Qian, Dongsheng, Song, Yanli, Wu, Wenlin, Wang, Liqiang, Zhang, Lai Chang, Hua, Lin, National Key R & D Program of China (No. 2020YFA0714900), National Natural Science Foundation of China (Grant No. 51975441, No. 51901165), Application Foundation Frontier Project of Wuhan, Hubei, China (No. 2020010601012171), “Chu Tian Scholar” project of Hubei Province, China (CTXZ2017-05), Overseas Expertise Introduction Project for Discipline Innovation, China (B17034) Innovative Research Team Development Program of Ministry of Education, China (IRT_17R83), Fundamental Research Funds for the Center Universities (WUT: 2021III026JC, 2020IVB022), State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology., Liu, Chang, Yin, Fei, Xie, Lechun, Qian, Dongsheng, Song, Yanli, Wu, Wenlin, Wang, Liqiang, Zhang, Lai Chang, and Hua, Lin
Abstract: Liu, C., Yin, F., Xie, L., Qian, D., Song, Y., Wu, W., ... & Hua, L. (2022). Evolution of grain boundary and texture in TC11 titanium alloy under electroshock treatment. Journal of Alloys and Compounds, 904, 163969. https://doi.org/10.1016/j.jallcom.2022.163969

22. Design and development of a mobile health (mHealth) platform for dementia prevention in the prevention of dementia by mobile phone applications (PRODEMOS) project

Author: European Union's Horizon 2020 Research and Innovation Programme National Key R&D Programme of China, Hafdi, Melanie, Eggink, Esmé, Hoevenaar-Blom, Marieke P., Witvliet, M. Patrick, Andrieu, Sandrine, Barnes, Linda, Brayne, Carol, Brooks, Rachael, Coley, Nicola, Georges, Jean, van der Groep, Abraham, van Marwijk, Harm, van der Meijden, Mark, Song, Libin, Song, Manshu, Wang, Youxin, Wang, Wenzhi, Wang, Wei, Wimo, Anders, Ye, Xiaoyan, Moll van Charante, Eric P., Richard, Edo, PRODEMOS consortium, European Union's Horizon 2020 Research and Innovation Programme National Key R&D Programme of China, Hafdi, Melanie, Eggink, Esmé, Hoevenaar-Blom, Marieke P., Witvliet, M. Patrick, Andrieu, Sandrine, Barnes, Linda, Brayne, Carol, Brooks, Rachael, Coley, Nicola, Georges, Jean, van der Groep, Abraham, van Marwijk, Harm, van der Meijden, Mark, Song, Libin, Song, Manshu, Wang, Youxin, Wang, Wenzhi, Wang, Wei, Wimo, Anders, Ye, Xiaoyan, Moll van Charante, Eric P., Richard, Edo, and PRODEMOS consortium
Abstract: Hafdi, M., Eggink, E., Hoevenaar-Blom, M. P., Witvliet, M. P., Andrieu, S., Barnes, L., . . . Richard, E. (2021). Design and development of a mobile health (mHealth) platform for dementia prevention in the prevention of dementia by mobile phone applications (PRODEMOS) project. Frontiers in Neurology, 12, article 733878. https://doi.org/10.3389/fneur.2021.733878

23. Photo-thermo catalytic dry reforming of methane over Ni-Ir/SiO2 catalyst

Author: National Natural Science Foundation of China National Key R&D Program Major Project of Natural Science Foundation of Colleges and Universities of Jiangsu Provincial Department of Education, Zhou, Ruiming, Sun, Jiaming, Zhang, Jinqiang, Wang, Liang, Liu, Peng, Zhu, Yuezhao, Sun, Hongqi, Jiang, Yichen, Chen, Haijun, National Natural Science Foundation of China National Key R&D Program Major Project of Natural Science Foundation of Colleges and Universities of Jiangsu Provincial Department of Education, Zhou, Ruiming, Sun, Jiaming, Zhang, Jinqiang, Wang, Liang, Liu, Peng, Zhu, Yuezhao, Sun, Hongqi, Jiang, Yichen, and Chen, Haijun
Abstract: Zhou, R., Sun, J., Zhang, J., Wang, L., Liu, P., Zhu, Y., . . . Chen, H. (2021). Photo-thermo catalytic dry reforming of methane over Ni-Ir/SiO2 catalyst. Scientia Sinica Chimica, 51(11), 1539-1548. https://doi.org/10.1360/SSC-2021-0008

24. Impact Assessment of Asphalt Concrete in Geogrid-Reinforced-Pile-Supported Embankment During High-Speed Train Traffic

Author: Ishola Valere Loic Chango, Goubi Cyriaque Assogba, Muhan Yan, Ling Xianzhang, Josue Girece Mitobaba, National Key R&D Program of China, State Key Program of the National Natural Science Foundation of China, National Major Scientific Instruments Development Project of China, and Technology Research and Development Plan Program of Heilongjiang Province
Subjects: Building and Construction, 3D-railway finite element model, asphalt concrete, dynamic response, finite element model (FEM), railway system, train moving load, Civil and Structural Engineering
Abstract: Railroad structural behaviour is a significant factor for safety and comfort during high-speed train operation. Intending to improve railway performance, increase its bearing capacity, and reduce vibrations induced by train passage, asphalt concrete has become a material to be integrated into railway construction. Despite several studies evaluating asphalt concrete effect on the railway mechanical behaviour, its impact assessment remains poorly understood. This study investigates the impact of asphalt concrete material in the geogrid-reinforced-pile-supported embankment structure subjected to high-speed train moving. A 3D nonlinear finite element model was developed to simulate Harbin (Dalian (China) instrumented railroad test section accurately. The high-speed train moving load was modelled as a transitory dynamic load via a user-defined subroutine 3D load in which the track irregularity is incorporated. The established model was effectively validated by the vibration acceleration and stress measured in the field test section. The asphalt concrete viscoelasticity behaviour was incorporated into the 3D geogrid-reinforced-pile-supported embankment finite element model through the Prony series to characterise its mechanical response better. The impact of asphalt concrete material in maintaining a low and constant structural vibration, regardless of train weight level, moving speed variations, and weather conditions were investigated, analysed and discussed.
Published: 2022
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25. A Distracted Driving Discrimination Method Based on the Facial Feature Triangle and Bayesian Network

Author: Feng, Tianliu, Wei, Lingxiang, E, Wenjuan, Zhao, Pengfei, Li, Zhe, Ji, Yuchuan, and National Natural Science Foundation of China under Grant [number 51908388], the National Key R&D Program of China under Grant [number 2018YFB1600500], and Beijing Postdoctoral Research Foundation [number 2021-zz-111]
Subjects: Bayesian network, distracted driving behaviour, facial feature triangle, feature point recognition, head posture, traffic safety
Abstract: Distracted driving is one of the main causes of road crashes. Therefore, effective distinguishing of distracted driving behaviour and its category is the key to reducing the incidence of road crashes. To identify distracted driving behaviour accurately and effectively, this paper uses the head posture as a relevant variable and realizes the classification of distracted driving behaviour based on the relevant literature and investigation. Adistracted driving discrimination algorithm based on the facial feature triangle is proposed. In the proposed algorithm, the Bayesian network is employed to judge driving behaviour categories. The proposed algorithm is verified by experiments using data from 20 volunteers. The experimental results show that the discrimination accuracy of the proposed algorithm is as high as 90%, which indicates that the head posture parameters used in this study are closely related to the distracted driving state. The results show that the proposed algorithm achieves high accuracy in the discrimination and classification of distracted driving behaviour and can effectively reduce the accident rate caused by distracted driving. Moreover, it can provide a basis for the research of distracted driving behaviour and is conducive to the formulation of the corresponding laws and regulations.
Published: 2023

26. Nutrient-dependent regulation of β-cell proinsulin content

Author: Xiaoxi Xu, Anoop Arunagiri, Maroof Alam, Leena Haataja, Charles R. Evans, Ivy Zhao, Roberto Castro-Gutierrez, Holger A. Russ, Caroline Demangel, Ling Qi, Billy Tsai, Ming Liu, Peter Arvan, University of Michigan [Ann Arbor], University of Michigan System, Tianjin Medical University, University of Florida [Gainesville] (UF), Immunobiologie et Thérapie - Immunobiology and Therapy, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Michigan [Dearborn], This work was supported primarily by NIH R01 DK111174 (to LQ, BT, and PA) and DK48280 (to PA). The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding was also from the National Natural Science Foundation of China (82000796), the PUMC Youth Fund supported by the Fundamental Research Funds for the Central Universities (3332020080), the Tianjin Municipal Science and Technology Commission (18JCQNJC82100), and the China Scholarship Council (201806940006) to XX, as well as the National Natural Science Foundation of China 81620108004 and 81830025, and the National Key R&D Program 2019YFA0802502 to M.L. The H.R. lab has been supported by NIH/NIDDK grants NIDDK RRID:SCR014393, and UC24 DK104162, R01DK12044, R01DK132387, and the JDRF. C.D. acknowledges core support from Institut Pasteur and INSERM (U1224).
Subjects: amino acids, endoplasmic reticulum, preproinsulin, [SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology, Cell Biology, phospho-eIF2α, biosynthesis, Molecular Biology, Biochemistry
Abstract: International audience; Insulin is made from proinsulin, but the extent to which fasting/feeding controls the homeostatically-regulated proinsulin pool in pancreatic β-cells remains largely unknown. Here, we first examined β-cell lines (INS1E and Min6, which proliferate slowly and are routinely fed fresh medium every 2-3 days) and found that the proinsulin pool size responds to each feeding within 1-2 hours; affected both by the quantity of fresh nutrients and the frequency with which they are provided. We observed no effect of nutrient feeding on the overall rate of proinsulin turnover as quantified from cycloheximide-chase experiments. We show that nutrient feeding is primarily linked to rapid de-phosphorylation of translation initiation factor eIF2α, presaging increased proinsulin levels (and thereafter, insulin levels), followed by its re-phosphorylation during the ensuing hours that correspond to a fall in proinsulin levels. The decline of proinsulin levels is blunted by the integrated stress response inhibitor, ISRIB, or by inhibition of eIF2α re-phosphorylation with a GCN2 (not PERK) kinase inhibitor. In addition, we demonstrate that amino acids contribute importantly to the proinsulin pool; mass spectrometry shows that β-cells avidly consume extracellular glutamine, serine, and cysteine. Finally, we show that in both rodent and human pancreatic islets, fresh nutrient availability dynamically increases preproinsulin, which can be quantified without pulse-labeling. Thus, the proinsulin available for insulin biosynthesis is rhythmically controlled by fasting/feeding cycles.
Published: 2023
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27. Interfacial engineering of ferromagnetism in wafer-scale van der Waals Fe4GeTe2 far above room temperature

Author: Hangtian Wang, Haichang Lu, Zongxia Guo, Ang Li, Peichen Wu, Jing Li, Weiran Xie, Zhimei Sun, Peng Li, Héloïse Damas, Anna Maria Friedel, Sylvie Migot, Jaafar Ghanbaja, Luc Moreau, Yannick Fagot-Revurat, Sébastien Petit-Watelot, Thomas Hauet, John Robertson, Stéphane Mangin, Weisheng Zhao, Tianxiao Nie, Wang, Hangtian [0000-0003-2844-8635], Lu, Haichang [0000-0002-5831-2061], Li, Peng [0000-0001-8491-0199], Friedel, Anna Maria [0000-0002-7523-0375], Petit-Watelot, Sébastien [0000-0002-0697-8929], Hauet, Thomas [0000-0001-5637-0690], Mangin, Stéphane [0000-0001-6046-0437], Zhao, Weisheng [0000-0001-8088-0404], Nie, Tianxiao [0000-0001-9067-9931], Apollo - University of Cambridge Repository, Beihang University (BUAA), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), University of Cambridge [UK] (CAM), Auburn University (AU), Technische Universität Kaiserslautern (TU Kaiserslautern), W.Z., T.N., and H.L. acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 62274009, 61774013, and 12204027), the National Key R&D Program of China (Grant No. 2018YFB0407602), the International Collaboration Project (Grant No. B16001), and the National Key Technology Program of China (Grant No. 2017ZX01032101). This work was also supported by FEDER-FSE Lorraine et Massif des Vosges 2014–2020, a European Union Program (to T.H.). H.T. Wang thanks the support from the Academic Excellence Founda- tion of BUAA for PhD Students., and European Project
Subjects: Multidisciplinary, General Physics and Astronomy, General Chemistry, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], 51 Physical Sciences, General Biochemistry, Genetics and Molecular Biology, 5108 Quantum Physics
Abstract: Despite recent advances in exfoliated vdW ferromagnets, the widespread application of 2D magnetism requires a Curie temperature (Tc) above room temperature as well as a stable and controllable magnetic anisotropy. Here we demonstrate a large-scale iron-based vdW material Fe4GeTe2 with the Tc reaching ~530 K. We confirmed the high-temperature ferromagnetism by multiple characterizations. Theoretical calculations suggested that the interface-induced right shift of the localized states for unpaired Fe d electrons is the reason for the enhanced Tc, which was confirmed by ultraviolet photoelectron spectroscopy. Moreover, by precisely tailoring Fe concentration we achieved arbitrary control of magnetic anisotropy between out-of-plane and in-plane without inducing any phase disorders. Our finding sheds light on the high potential of Fe4GeTe2 in spintronics, which may open opportunities for room-temperature application of all-vdW spintronic devices.
Published: 2023
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28. Supramolecular heptanuclear Ln–Cu complexes involving nitronyl nitroxide biradicals: structure and magnetic behavior

Author: Lu Xi, Chao-Yi Jin, Hong-Wei Song, Xiao-Tong Wang, Li-Cun Li, Jean-Pascal Sutter, Key Laboratory of Advanced Energy Materials Chemistry, Nankai University, Nankai University (NKU), Laboratoire de chimie de coordination (LCC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), National Key R&D Program of China (2018YFA0306002), and National Natural Science Foundation of China (No. 21773122)
Subjects: Inorganic Chemistry, [CHIM.COOR]Chemical Sciences/Coordination chemistry
Abstract: International audience; Four novel heptanuclear Ln–Cu complexes with the formula [Ln2Cu(hfac)8(NITPhTzbis)2][LnCu(hfac)5(NITPhTzbis)]2 (LnCu = YCu 1, TbCu 2, DyCu 3 and HoCu 4; hfac = hexafluoroacetylacetonate) were successfully constructed by employing the triazole functionalized nitronyl nitroxide biradical ligand NITPh-Tzbis (NITPh-Tzbis = 5-(1,2,4-triazolyl)-1,3-bis(1′-oxyl-3′-oxido-4′,4′,5′,5′-tetramethyl-4,5-hydro-1H-imidazol-2-yl)benzene). These hetero-tri-spin complexes are composed of two biradical-bridged dinuclear [(LnCu(hfac)5(NITPhTzbis)] units and one trinuclear [Ln2Cu(hfac)8(NITPhTzbis)2] unit which form a heptanuclear supramolecular structure through π–π interactions. Magnetic susceptibility investigations indicate that ferromagnetic exchange interactions dominate at low temperature for this supramolecular system which can be attributed to the Ln–nitroxide exchange and intramolecular NIT⋯NIT coupling mediated by the m-phenylene moiety. The DyCu derivative was found to exhibit a slow magnetic relaxation behavior.
Published: 2022
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29. Enhancing the Magnetization Blocking Energy of Biradical‐Metal System by Merging Discrete Complexes into One‐Dimensional Chains

Author: Junfang Xie, Jing Han, Xiaohui Huang, Chaoyi Jin, Licun Li, Jean‐Pascal Sutter, Key Laboratory of Advanced Energy Materials Chemistry, Nankai University, Nankai University (NKU), Laboratoire de chimie de coordination (LCC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), National Key R&D Program of China (Grant Number: 2018YFA0306002), and National Natural Science Foundation of China (Grant Number: No. 21773122)
Subjects: 2p–3d-4f, Single-chain magnets, Organic Chemistry, Magnetic properties, Nitronyl nitroxide biradical, [CHIM.COOR]Chemical Sciences/Coordination chemistry, General Chemistry, Structural transformation, Catalysis
Abstract: International audience; The reaction of nitronyl nitroxide biradical NITPhMeImbis [5-(2-methylimidazole)-1,3-bis(1-oxyl-3’-oxido-4’,4’,5’,5’-tetramethyl-4,5-hydro-1H-imidazol-2-yl)-benzene] with Ln(hfac)3 ⋅ 2H2O and Cu(hfac)2 (hfac=hexafluoroacetylacetonate), led to two series of 2p–3d-4f complexes, namely, nona-spin clusters, [Ln2Cu3(hfac)12(NITPhMeImbis)2] (Ln=Gd 1, Dy 2), or one-dimensional chains [LnCu2(hfac)7(NITPhMeImbis)] (Ln=Y 3, Dy 4, Tb 5) depending on the temperature of the reaction. All five complexes contain a biradical-Ln unit in which the biradical chelates the LnIII ion by the means of one aminoxyl (i. e. NO) group of each NIT unit. For the discrete complexes, a Cu(hfac)2 links two biradical-Ln units via one of the remaining NO groups, while for the chain compounds, the two remaining NO groups of the biradical-Ln moiety are each coordinated to a Cu(hfac)2 unit to form a 1D coordination polymer. Moreover, a terminal Cu(hfac)2 unit is coordinated to the imidazole-N atom of the NITPhMeImbis ligand. Spin dynamics investigations evidenced the onset of slow relaxation of the magnetization for 2, whereas 4 and 5 exhibit a typical single-chain magnet behavior. This highlights the vital role of the 1D spin correlation in the blocking of the magnetization. These results illustrate that from the same basic building blocks, magnetic relaxation can be carefully modulated by structural adjustments.
Published: 2023
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30. Facile Assembly of Hybrid Micro-Supercapacitors for a Sunlight-Powered Energy Storage System

Author: Min Li, Chen Jia, Danyu Zhang, Yunyun Luo, Lu Wang, Ping Yang, Guoxi Luo, Libo Zhao, Rabah Boukherroub, Zhuangde Jiang, Xi'an Jiaotong University (Xjtu), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), This work was supported by the National Key Research & Development (R&D) Program of China (Grant 2021YFB2012000), the National Natural Science Foundation of China (Grants 52175548 and 51890884), and the Fundamental Research Funds for the Central Universities (Grant xpt012020004). RB thanks the ANR for financial support of the project LEAP-RE 'SIREVIVAL'., and ANR-22-LERE-0003,SIREVIVAL,Dispositifs à base de Si pour les énergies renouvelables : Recyclage et renaissance des modules photovoltaïques(2022)
Subjects: [SPI]Engineering Sciences [physics], drop-coating, carbon nanotubes, micro-supercapacitors, energy storage system, electrodeposition, General Materials Science
Abstract: International audience; Herein, hybrid micro-supercapacitors (MSCs), consisting of positive CoNi layer double hydroxides (LDHs) decorated on carbon nanotubes (CoNi LDHs@CNTs) and negative CNT electrodes, were assembled by facile drop-coated and electrodeposition methods. The as-fabricated MSCs were optimized in view of electrochemical performance, and the CoNi LDHs-2@CNTs//CNT MSC exhibited a favorable performance and was thus chosen to be the candidate for MSC device package. The packaged CoNi LDHs-2@CNTs//CNT MSC demonstrated a large areal capacitance of 11.0 mF·cm–2 at a current density of 0.08 mA·cm–2, a good rate performance (56% areal capacitance retained at a higher current density of 0.4 mA·cm–2), and a favorable cycling stability and reversibility (92% of the original areal capacitance was retained after 5000 cycles). Furthermore, the MSC device recorded an energy density of 1.5 μWh·cm–2 at a power density of 42.5 μW·cm–2 and was successfully applied for the storage of energy supplied by solar cells to operate a red light-emitting diode. All these findings demonstrated the promising practical energy storage application of the as-fabricated hybrid MSC devices in the construction of sunlight-powered energy storage systems.
Published: 2022
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31. Interactive Simulation of Scattering Effects in Participating Media Using a Neural Network Model

Author: Nicolas Holzschuch, Beibei Wang, Xiangxu Meng, Lu Wang, Liangsheng Ge, Shandong University, Nanjing University of Science and Technology (NJUST), Transformation Intégrée de la Matière Renouvelable (TIMR), Université de Technologie de Compiègne (UTC), Models and Algorithms for Visualization and Rendering (MAVERICK), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jean Kuntzmann (LJK), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), 61872223, National Natural Science Foundation of China, and 2017YFB0203000, National Key R and D Program of China
Subjects: Multiple Scattering, Artificial neural network, Computer science, business.industry, Scattering, Neural Network, 020207 software engineering, 02 engineering and technology, Computer Graphics and Computer-Aided Design, [INFO.INFO-GR]Computer Science [cs]/Graphics [cs.GR], Rendering (computer graphics), Computational science, Participating Media, Interactive simulation, Signal Processing, 0202 electrical engineering, electronic engineering, information engineering, Computer Vision and Pattern Recognition, Photonics, business, Real-time, Software, ComputingMethodologies_COMPUTERGRAPHICS
Abstract: International audience; Rendering participating media is important to the creation of photorealistic images. Participating media has a translucent aspect that comes from light being scattered inside the material. For materials with a small mean-free-path (mfp), multiple scattering effects dominate. Simulating these effects is computationally intensive, as it requires tracking a large number of scattering events inside the material. Existing approaches precompute multiple scattering events inside the material and store the results in a table. During rendering time, this table is used to compute the scattering effects. While these methods are faster than explicit scattering computation, they incur higher storage costs. In this paper, we present a new representation for double and multiple scattering effects that uses a neural network model. The scattering response from all homogeneous participating media is encoded into a neural network in a preprocessing step. At run time, the neural network is then used to predict the double and multiple scattering effects. We demonstrate the effects combined with Virtual Ray Lights (VRL), although our approach can be integrated with other rendering algorithms. Our algorithm is implemented on GPU. Double and multiple scattering effects for the entire participating media space are encoded using only 23.6 KB of memory. Our method achieves 50 ms per frame in typical scenes and provides results almost identical to the reference.
Published: 2021
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32. An efficient cobalt-nickel phosphate positive electrode for high-performance hybrid microsupercapacitors

Author: Li, Min, Jia, Chen, Zhang, Danyu, Luo, Yunyun, Ma, Yintao, Luo, Guoxi, Zhao, Libo, Wang, Lu, Li, Zhikang, Lin, Qijing, Yang, Ping, Zhu, Nan, Boukherroub, Rabah, Jiang, Zhuangde, Xi'an Jiaotong University (Xjtu), Hunan University [Changsha] (HNU), Beijing Wuzi University, National University of Singapore (NUS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Acknowledgements This work is supported by the Shaanxi 2023 Natural Science Basic Research Plan (grant number 2023-JC-QN-0489), the National Key Research & Development (R&D) Program of China (grant number 2022YFB3205400), the National Natural Science Foundation of China (grant numbers 52175548, U1909221), and the Chongqing Natural Science Basic Research Project (cstc2021jcyj-msxmX0801). R. B. thanks the ANR for financial support of the project 'SIREVIVAL' of the LEAP-RE programme that received funding from the European Union's Horizon 2020 Research and Innovation Program under Grant Agreement 963530., and ANR-22-LERE-0003,SIREVIVAL,Dispositifs à base de Si pour les énergies renouvelables : Recyclage et renaissance des modules photovoltaïques(2022)
Subjects: [PHYS]Physics [physics], [SPI]Engineering Sciences [physics], Cobalt nickel phosphate, Microsupercapacitor, Renewable Energy, Sustainability and the Environment, Energy storage system, Carbon nanotubes, Energy Engineering and Power Technology, Electrical and Electronic Engineering, Flexible
Abstract: International audience; Flexible energy storage devices play significant role in wearable and portable electronics. Herein, a cobalt-nickel phosphate (CoNiP2O7) composite was synthesized on conductive carbon nanotubes (CNTs) substrate by facile one-step electrochemical deposition method, forming a binder-free CoNiP2O7@CNTs positive electrode for microsupercapacitors (MSCs). Combined with a CNTs substrate on the opposite side of interdigitated electrodes, a CoNiP2O7@CNTs//CNTs hybrid MSC device was assembled. It displayed good electrochemical performance with a largest areal capacitance of 20.9 mF·cm−2 at 0.08 mA·cm−2 and an energy density of 2.9 μWh·cm−2. To construct a self-powered solar cell energy storage system, the proposed MSC device was utilized for energy storage and further provided power for red light-emitting diode (LED), forming natural energy collection-conversion-storage-utilization system. The results of this study offer a simple design route for flexible energy storage devices.
Published: 2023
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33. Diagnosis after Zooming in: A Multi-label Classification Model by Imitating Doctor Reading Habits to Diagnose Brain Diseases

Author: Ruiqian Wang, Guanghui Fu, Jianqiang Li, Yan Pei, Beijing University of Technology, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Computer Science Division, University of Aizu, Aizuwakamatsu, Japan, University of Aizu [Japan] (UoA), and This study is supported by the National Key R&D Program of China with project no. 2020YFB2104402. Guanghui Fu is supported by the Chinese Government Scholarship provided by China Scholarship Council (CSC).
Subjects: Human-AI interaction, Attention mechanism, Medical image classification, Interpretability, General Medicine, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: International audience; Purpose: Computed tomography (CT) has the advantages of being low cost and noninvasive and is a primary diagnostic method for brain diseases. However, it is a challenge for junior radiologists to diagnose CT images accurately and comprehensively. It is necessary to build a system that can help doctors diagnose and provide an explanation of the predictions. Despite the success of deep learning algorithms in the field of medical image analysis, the task of brain disease classification still faces challenges: Researchers lack attention to complex manual labeling requirements and the incompleteness of prediction explanations. More importantly, most studies only measure the performance of the algorithm, but do not measure the effectiveness of the algorithm in the actual diagnosis of doctors. Methods: In this paper, we propose a model called DrCT2 that can detect brain diseases without using image-level labels and provide a more comprehensive explanation at both the slice and sequence levels. This model achieves reliable performance by imitating human expert reading habits: targeted scaling of primary images from the full slice scans and observation of suspicious lesions for diagnosis. We evaluated our model on two open-access data sets: CQ500 and the RSNA Intracranial Hemorrhage Detection Challenge. In addition, we defined three tasks to comprehensively evaluate model interpretability by measuring whether the algorithm can select key images with lesions. To verify the algorithm from the perspective of practical application, three junior radiologists were invited to participate in the experiments, comparing the effects before and after human-computer cooperation in different aspects. Results: The method achieved F1-scores of 0.9370 on CQ500 and 0.8700 on the RSNA data set. The results show that our model has good interpretability under the premise of good performance. Human radiologist evaluation experiments have proven that our model can effectively improve the accuracy of the diagnosis and improve efficiency. Conclusions: We proposed a model that can simultaneously detect multiple brain diseases.The report generated by the model can assist doctors in avoiding missed diagnoses, and it has good clinical application value.
Published: 2022
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34. An unsupervised domain adaptation brain CT segmentation method across image modalities and diseases

Author: Daqiang Dong, Guanghui Fu, Jianqiang Li, Yan Pei, Yueda Chen, Beijing University of Technology, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Computer Science Division, University of Aizu, Aizuwakamatsu, Japan, University of Aizu [Japan] (UoA), Tianjin Huanhu Hospital [Tianjin], and The study is supported by the National Key R&D Pro-gram of China with project no. 2020YFB2104402 and Bei-jing Chaoyang Collaborative Innovation project with no. CYXC2010. Guanghui Fu is supported by the Chinese Gov-ernment Scholarship provided by China Scholarship Council (CSC).
Subjects: Intraparenchymal hemorrhage, Domain adaptation, Artificial Intelligence, General Engineering, Deep learning, Image synthesis, Semantic segmentation, Computer Science Applications, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience; Computed tomography (CT) is the primary diagnostic tool for brain diseases. To determine the appropriate treatment plan, it is necessary to ascertain the patient's bleeding volume. Automatic segmentation algorithms for hemorrhagic lesions can significantly improve efficiency and avoid treatment delays. However, for deep supervised learning algorithms, a large amount of labeled training data is usually required, making them difficult to apply clinically. In this study, we propose an unsupervised domain adaptation method that is an unsupervised domain adaptation segmentation model that can be trained across modalities and diseases. We call it AMD-DAS for brain CT hemorrhage segmentation tasks. This circumvents the heavy data labeling task by converting the source domain data (MRI with glioma) to our task's required data (CT with Intraparenchymal hemorrhage (IPH)). Our model implements a two-stage domain adaptation process to achieve this objective. In the first stage, we train a pseudo-CT image synthesis network using the CycleGAN architecture through a matching mechanism and domain adaptation approach. In the second stage, we use the model trained in the first stage to synthesize the pseudo-CT images. We use the pseudo-CT with source domain labels and real CT images to train a domain-adaptation segmentation model. Our method exhibits a better performance than the basic one-stage domain adaptation segmentation method (+11.55 Dice score) and achieves an 86.93 Dice score in the IPH unsupervised segmentation task. Our model can be trained without using a ground-truth label, therefore increasing its application potential. Our implementation is publicly available at https://github.com/GuanghuiFU/AMD-DAS-Brain-CT-Segmentation.
Published: 2022
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35. Proteomics Evidence of a Systemic Response to Desiccation in the Resurrection Plant Haberlea rhodopensis

Author: Petko Mladenov, Diana Zasheva, Sébastien Planchon, Céline C. Leclercq, Denis Falconet, Lucas Moyet, Sabine Brugière, Daniela Moyankova, Magdalena Tchorbadjieva, Myriam Ferro, Norbert Rolland, Jenny Renaut, Dimitar Djilianov, Xin Deng, Institute of Botany [Beijing] (IB-CAS), Chinese Academy of Sciences [Beijing] (CAS), Physiologie cellulaire et végétale (LPCV), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Agrobioinstitute, Agricultural Academy Bulgaria, Bulgarian Academy of Sciences (BAS), Luxembourg Institute of Science and Technology (LIST), LIPID, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Dynamique du protéome et biogenèse du chloroplaste (ChloroGenesis), Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Medical University of Sofia [Bulgarie], The Fonds National de la Recherche, Luxembourg (Project SMARTWALL C15/SR/10240550), CAS PRESIDENT’S INTERNATIONAL FELLOWSHIP INITIATIVE GRANT (2021PB0101), National Key R&D program of China (2021YFE0102600), Bulgarian Science Fund (KP06-H-41-IP-Kitai), ANR-10-INBS-0008,ProFI,Infrastructure Française de Protéomique(2010), ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017), Martin-Laffon, Jacqueline, Infrastructure Française de Protéomique - - ProFI2010 - ANR-10-INBS-0008 - INBS - VALID, and CBH-EUR-GS - - CBH-EUR-GS2017 - ANR-17-EURE-0003 - EURE - VALID
Subjects: dehydrin, Organic Chemistry, drought stress, systems biology, General Medicine, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, Catalysis, Computer Science Applications, subcellular fractionation, [SDV.BV.BOT] Life Sciences [q-bio]/Vegetal Biology/Botanics, Inorganic Chemistry, resurrection plant, proteomics, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy
Abstract: International audience; Global warming and drought stress are expected to have a negative impact on agricultural productivity. Desiccation-tolerant species, which are able to tolerate the almost complete desiccation of their vegetative tissues, are appropriate models to study extreme drought tolerance and identify novel approaches to improve the resistance of crops to drought stress. In the present study, to better understand what makes resurrection plants extremely tolerant to drought, we performed transmission electron microscopy and integrative large-scale proteomics, including organellar and phosphorylation proteomics, and combined these investigations with previously published transcriptomic and metabolomics data from the resurrection plant Haberlea rhodopensis. The results revealed new evidence about organelle and cell preservation, posttranscriptional and posttranslational regulation, photosynthesis, primary metabolism, autophagy, and cell death in response to desiccation in H. rhodopensis. Different protective intrinsically disordered proteins, such as late embryogenesis abundant (LEA) proteins, thaumatin-like proteins (TLPs), and heat shock proteins (HSPs), were detected. We also found a constitutively abundant dehydrin in H. rhodopensis whose phosphorylation levels increased under stress in the chloroplast fraction. This integrative multi-omics analysis revealed a systemic response to desiccation in H. rhodopensis and certain targets for further genomic and evolutionary studies on DT mechanisms and genetic engineering towards the improvement of drought tolerance in crops.
Published: 2022
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36. Modeling canopy photosynthesis and light interception partitioning among shoots in bi-axis and single-axis apple trees (Malus domestica Borkh.)

Author: Mingyu Han, Sayed Hussain, Evelyne Costes, Xiaolong Ma, Weiwei Yang, Dong Zhang, Doudou Ma, Jidong Shi, Northwest A and F University, Shihezi University, Shaanxi Huasheng (Group) Corp. Fruit Co., Abdul Wali Khan University, Architecture et Fonctionnement des Espèces Fruitières [AGAP] (AFEF), Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), National Natural Science Foundation of China (NSFC) (31860527), Shaanxi province Key Research and Development Program (2017ZDXM-NY-511019, 2016KTZDNY01-04), China Apple Research System CARS-27, National Key R&D Program Projects 2018YFD1000200, and China Scholarship Council
Subjects: 0106 biological sciences, 0301 basic medicine, Canopy, Malus, Physiology, Vegetative reproduction, Plant Science, 01 natural sciences, Training system, 03 medical and health sciences, Vegetative shoot, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Fruiting shoot, STAR, Ecology, biology, Forestry, 15. Life on land, biology.organism_classification, 3D digitizing, Horticulture, 030104 developmental biology, Mutual shading, Shoot, Allometry, Shading, Interception, Orchard, Virtual orchard, 010606 plant biology & botany
Abstract: International audience; Key message Bi-axis training increased vegetative shoot light interception and modeled photosynthetic rate, and reduced fruiting shoot mutual shading and vegetative growth by optimizing canopy structure compared to single-axis in young apple trees. Improving light interception and distribution within canopy are constant objectives of training through manipulating tree architecture. A bi-axis training system with two primary scaffolds has been proposed to improve flowering and dry matter production in apple trees. In this study, 'Fuji' apple trees trained using a bi-axis or single-axis training system were compared. Twelve three-dimensional (3D) virtual apple trees were reconstructed by combining 3D digitizing and allometric relationships for three shoot types (vegetative long shoot, VL; fruiting shoot, FS; vegetative short shoot, VS), to evaluate canopy structure impacts on light interception. Light interception efficiency was evaluated by silhouette to total area ratio (STAR). The potential canopy photosynthetic rate was evaluated by the eco-physiological RATP model. The leaf area of VL in bi-axis trained trees was approximately 40% lower than that in single-axis trees. Lower leaf area and more uniform spatial distribution were noted in VL in bi-axis than in single-axis trees. This led to more even spatial light distribution and more shoots having higher STAR in bi-axis than in single-axis trees, regardless of the whole tree or shoot type. In the virtual orchard, bi-axis trees had a 25% and 10% STAR increase in VS and VL, respectively, but a similar STAR for FS compared to single-axis trees. Mutual shading between neighboring trees in the virtual orchard made of bi-axis trees was significantly lower than that with single-axis trees for FS. The modeled canopy net photosynthetic rate was 26% higher in bi-axis than in single-axis trees. With the increase in tree age, the projected leaf area increased, but the porosity of the canopy decreased, and mutual shading increased for the whole canopy and all shoot types, irrespective of training systems. These results indicated that manipulating scaffolds in apple trees can regulate canopy structure, light interception, and vegetative growth during the early developmental stages.
Published: 2021
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37. A metal-radical hetero-tri-spin SCM with methyl–pyrazole–nitronyl nitroxide bridges

Author: Kang Wang, Xiaohui Huang, Junfang Xie, Jing Han, Licun Li, Jean-Pascal Sutter, Key Laboratory of Advanced Energy Materials Chemistry, Nankai University, Nankai University (NKU), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), National Key R&D Program of China (2018YFA0306002), National Natural Science Foundation of China (No. 21773122), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: chemistry.chemical_classification, Nitroxide mediated radical polymerization, Materials science, 010405 organic chemistry, Band gap, Demagnetizing field, Crystal structure, Polymer, Pyrazole, 010402 general chemistry, 01 natural sciences, 3. Good health, 0104 chemical sciences, Ion, Inorganic Chemistry, chemistry.chemical_compound, Crystallography, chemistry, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Linker
Abstract: International audience; The preparation, crystal structures, and magnetic properties of a family of hetero-tri-spin 1-D coordination polymers with the formula [Ln(hfac)3Cu(hfac)2(4-NIT-MePyz)2] (Ln = Gd, 1, Tb, 2, Dy, 3; hfac = hexafluoroacetylacetonate; 4-NIT-MePyz = 2-{4-(1-methyl)-pyrazolyl}-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide) are reported. In these complexes, the 4-NIT-MePyz radical acts as a linker to bridge the CuII and LnIII ions through its pyrazole and aminoxyl groups to form a chain structure. Magnetic properties typical of spin-chains are observed for Dy and Tb derivatives but single-chain magnet (SCM) behavior was evidenced only for the Tb compound which is characterized by an energy gap for demagnetization Δτ/kB of 31 K.
Published: 2021
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38. MaXB3 Modulates MaNAC2, MaACS1, and MaACO1 Stability to Repress Ethylene Biosynthesis during Banana Fruit Ripening

Author: Mondher Bouzayen, Zhengguo Li, Julien Pirrello, Wei Wei, Wei Deng, Wei Shan, Jian-fei Kuang, Wang-jin Lu, Zhong-Qi Fan, Jian-ye Chen, South China Agricultural University (SCAU), Chinese Academy of Agricultural Sciences (CAAS), Chongqing University [Chongqing], Génomique et Biotechnologie des Fruits (GBF), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and National Key R&D Program of China (grant no. 2016YFD0400100), the National Natural Science Foundation of China (grant nos. 31830071, 31701652, and 31372111), the National Natural Science Foundation of Guangdong Province (grant no. 2017A030310353) and the China Agriculture Research System (grant no. CARS–31–11).
Subjects: 0106 biological sciences, Regulation of gene expression, Ethylene, biology, Physiology, food and beverages, Ripening, Plant Science, 01 natural sciences, Cell biology, Ubiquitin ligase, chemistry.chemical_compound, chemistry, Ubiquitin, Biosynthesis, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Genetics, biology.protein, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Post-translational regulation, Climacteric, 010606 plant biology & botany
Abstract: Ethylene plays a critical regulatory role in climacteric fruit ripening, and its biosynthesis is fine-tuned at the transcriptional and posttranslational levels. Nevertheless, the mechanistic link between transcriptional and posttranslational regulation of ethylene biosynthesis during fruit ripening is largely unknown. This study uncovers a coordinated transcriptional and posttranslational mechanism of controlling ethylene biosynthesis during banana (Musa acuminata) fruit ripening. NAC (NAM, ATAF, and CUC) proteins MaNAC1 and MaNAC2 repress the expression of MaERF11, a protein previously known to negatively regulate ethylene biosynthesis genes MaACS1 and MaACO1. A RING E3 ligase MaXB3 interacts with MaNAC2 to promote its ubiquitination and degradation, leading to the inhibition of MaNAC2-mediated transcriptional repression. In addition, MaXB3 also targets MaACS1 and MaACO1 for proteasome degradation. Further evidence supporting the role of MaXB3 is provided by its transient and ectopic overexpression in banana fruit and tomato (Solanum lycopersicum), respectively, which delays fruit ripening via repressing ethylene biosynthesis and thus ethylene response. Strikingly, MaNAC1 and MaNAC2 directly repress MaXB3 expression, suggesting a feedback regulatory mechanism that maintains a balance of MaNAC2, MaACS1, and MaACO1 levels. Collectively, our findings establish a multilayered regulatory cascade involving MaXB3, MaNACs, MaERF11, and MaACS1/MaACO1 that controls ethylene biosynthesis during climacteric ripening.
Published: 2020
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39. Macroscopic softening in granular materials from a mesoscale perspective

Author: Stéphane Bonelli, Antoine Wautier, François Nicot, Félix Darve, Jiaying Liu, State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University [China], Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Aix Marseille Université (AMU), Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Grenoble Alpes (UGA), Laboratoire sols, solides, structures - risques [Grenoble] (3SR), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and National Key R&D Program of China (No. 2018YFC1508500), China Scholarship Council (Joint PhD program, No. 201606270088) and China Postdoctoral Science Foundation (No. 2018M642910)
Subjects: Dilatant, softening, Materials science, granular materials, Mesoscale meteorology, strain localization, 02 engineering and technology, Granular material, rotation, [SPI]Engineering Sciences [physics], 0203 mechanical engineering, force chains, General Materials Science, Force chain, Softening, Mesoscopic physics, Applied Mathematics, Mechanical Engineering, DEM, mesomechanics, Mechanics, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 020303 mechanical engineering & transports, Mechanics of Materials, Modeling and Simulation, Hardening (metallurgy), 0210 nano-technology, Shear band
Abstract: Stress-oftening is one of the significant features experienced by cohesive-frictional granular materials subjected to deviatoric loading. This paper focuses on mesoscopic evolutions of the dense granular assembly during a typical drained biaxial test conducted by DEM, and proposes mesoscopically-based framework to interpret both hardening and softening mechanisms. In this context, force chains play a fundamental role as they form the strong contact phase in granular materials. Their geometrical and mechanical characteristics, as well as the surrounding structures, are defined and analyzed in terms of force chain bending evolution, local dilatancy, rotation and non-coaxiality between the principal stress and the geometrical orientation of force chains. By distinguishing two zones inside and outside shear band, force chain rotations are shown to be of opposite sign, which may contribute to the observed macroscopic softening as one of the origin of the structural softening.
Published: 2020
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40. Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins

Author: Souheyla Benfrid, Kyu‐Ho Park, Mariano Dellarole, James E Voss, Carole Tamietti, Gérard Pehau‐Arnaudet, Bertrand Raynal, Sébastien Brûlé, Patrick England, Xiaokang Zhang, Anastassia Mikhailova, Milena Hasan, Marie‐Noëlle Ungeheuer, Stéphane Petres, Scott B Biering, Eva Harris, Anavaj Sakuntabhai, Philippe Buchy, Veasna Duong, Philippe Dussart, Fasséli Coulibaly, François Bontems, Félix A Rey, Marie Flamand, Virologie Structurale - Structural Virology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes, Sorbonne Paris Cité, Plateforme BioImagerie Ultrastructurale – Ultrastructural BioImaging Platform (UTechS UBI), Institut Pasteur [Paris] (IP), Biophysique Moléculaire (plateforme) - Molecular Biophysics (platform), HIV, Inflammation et persistance - HIV, Inflammation and Persistence, Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB), Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Plateforme technologique Production et purification de protéines recombinantes – Production and Purification of Recombinant Proteins Technological Platform (PPR), University of California [Berkeley] (UC Berkeley), University of California (UC), Génétique du Développement humain - Human developmental genetics, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Monash University [Clayton], Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), This study benefited from the financial support of the Institut Pasteur ACIP-27-16 (P.D., V.D., M.F.), the Institut Pasteur Dengue Task Force (to MF), the Institut Pasteur INNOV-44-19 (M.F), the National Natural Science Foundation of China 31600606 (X.Z.), the National Key R&D Program of China 2016YFA0501100 (X.Z.), Guangdong Provincial Key Laboratory of Brain Connectome and Behavior 2017B030301017 (X.Z.), CAS Key Laboratory of Brain Connectome and Manipulation 2019DP173024 (X.Z.), the NIAID/NIH R01 AI24493 (E.H.) and R21 AI146464 (E.H.), ANR Equipex CACSICE ANR-11-EQPX-0008 (G.P.-A.)., The authors gratefully acknowledge the staff of the Kampong Cham Referral Hospital, the patients and parents who participated in the study, and the Arbovirus Team in the Virology Unit at the Institut Pasteur du Cambodge who contributed to this study. We acknowledge the participation of the ICAReB facility in setting up the recruitment of donors and the acquisition of blood samples, in particular Gloria Morizot, Bianca Liliana Perlaza, Sophie Chaouche, Linda Sangari, Céline Chapel, Philippe Esterre and Hélène Laude. We are most grateful to Christine Girard-Blanc and Evelyne Dufour for their contribution in producing and purifying the recombinant DENV NS1 protein, to Béatrice Poirier-Beaudouin and Cartini Mardi for their help in setting up the cytokine quantification assay, to Arvind Sharma for providing purified anti-E MAbs, to Mathilde Ban for preparing Fab-bound NS1-HDL complexes and to Xavier Montagutelli and Etienne Simon-Lorière for testing an in vivo protection assay. We thank M. Nilges and the Equipex CACSICE for providing the Falcon II direct detector and David Veesler for his help in acquiring the first electron microscopy images of the bovine NS1-HDL complex. Finally, we thank Sébastien Quesney, Alexandre Pachot and Karine Kaiser for their support. The synopsis figure was created with BioRender.com., and ANR-11-EQPX-0008,CACSICE,Centre d'analyse de systèmes complexes dans les environnements complexes(2011)
Subjects: Arbovirus, lipoprotein particle, viruses, accessory protein, virus diseases, Dengue Virus, Viral Nonstructural Proteins, biochemical phenomena, metabolism, and nutrition, Biochemistry, virulence factor, Dengue, molecular pathogenesis, Phagocytosis, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Genetics, Humans, [SDV.IMM]Life Sciences [q-bio]/Immunology, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, Molecular Biology, hemorrhagic fever
Abstract: International audience; The dengue virus nonstructural protein 1 (NS1) is a secreted virulence factor that modulates complement, activates immune cells and alters endothelial barriers. The molecular basis of these events remains incompletely understood. Here we describe a functional high affinity complex formed between NS1 and human high-density lipoproteins (HDL). Collapse of the soluble NS1 hexamer upon binding to the lipoprotein particle leads to the anchoring of amphipathic NS1 dimeric subunits into the HDL outer layer. The stable complex can be visualized by electron microscopy as a spherical HDL with rod-shaped NS1 dimers protruding from the surface. We further show that the assembly of NS1-HDL complexes triggers the production of pro-inflammatory cytokines in human primary macrophages while NS1 or HDL alone do not. Finally, we detect NS1 in complex with HDL and low-density lipoprotein (LDL) particles in the plasma of hospitalized dengue patients and observe NS1-apolipoprotein E-positive complexes accumulating overtime. The functional reprogramming of endogenous lipoprotein particles by NS1 as a means to exacerbate systemic inflammation during viral infection provides a new paradigm in dengue pathogenesis.
Published: 2022
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41. PDAT regulates PE as transient carbon sink alternative to triacylglycerol in Nannochloropsis

Author: Juan Yang, Jin Liu, Yufang Pan, Eric Maréchal, Alberto Amato, Meijing Liu, Yangmin Gong, Yantao Li, Hanhua Hu, Key Laboratory of Algal Biology, College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Peking University [Beijing], LIPID, Physiologie cellulaire et végétale (LPCV), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Oil Crops Research Institute, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture-Chinese Academy of Agricultural Sciences (CAAS), Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science and University of Maryland Baltimore County, The National Natural Science Foundation of China (41976119 and 91751117), Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDPB18), A CEA-Chinese Academy of Sciences bilateral program, The National Key R&D Program of China (2018YFA0902500), ANR-10-LABX-0049,GRAL,Grenoble Alliance for Integrated Structural Cell Biology(2010), and ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017)
Subjects: Carbon Sequestration, Physiology, Phosphatidylethanolamines, Saccharomyces cerevisiae, Plant Science, Carbon Dioxide, Plants, Microalgae, Genetics, lipids (amino acids, peptides, and proteins), [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Diacylglycerol O-Acyltransferase, Acyltransferases, Triglycerides, Research Articles
Abstract: Triacylglycerols (TAGs) are the main storage lipids in photosynthetic organisms under stress. In the oleaginous alga Nannochloropsis oceanica, while multiple acyl CoA:diacylglycerol (DAG) acyltransferases (NoDGATs) are involved in TAG production, the role of the unique phospholipid:DAG acyltransferase (NoPDAT) remains unknown. Here, we performed a functional complementation assay in TAG-deficient yeast (Saccharomyces cerevisiae) and an in vitro assay to probe the acyltransferase activity of NoPDAT. Subcellular localization, overexpression, and knockdown (KD) experiments were also conducted to elucidate the role of NoPDAT in N. oceanica. NoPDAT, residing at the outermost plastid membrane, does not phylogenetically fall into the clades of algae or plants and uses phosphatidylethanolamine (PE) and phosphatidylglycerol with 16:0, 16:1, and 18:1 at position sn-2 as acyl-donors in vivo. NoPDAT KD, not triggering any compensatory mechanism via DGATs, led to an ∼30% decrease of TAG content, accompanied by a vast accumulation of PEs rich in 16:0, 16:1, and 18:1 fatty acids (referred to as “LU-PE”) that was positively associated with CO2 availability. We conclude that the NoPDAT pathway is parallel to and independent of the NoDGAT pathway for oil production. LU-PE can serve as an alternative carbon sink for photosynthetically assimilated carbon in N. oceanica when PDAT-mediated TAG biosynthesis is compromised or under stress in the presence of high CO2 levels.
Published: 2022
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42. Parasitoid ecology along geographic gradients: lessons for climate change studies

Author: Jego, Lena, Li, Ruining, Roudine, Sacha, Ma, Chun-Sen, Le Lann, Cécile, Ma, Gang, van Baaren, Joan, Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Chinese Academy of Agricultural Sciences (CAAS), Hebei University, and This work was supported by the CNRS (Centre National de Recherche Scientifique), project IRP GRADIENTS, by the University of Rennes 1, by the French Embassy in China, by the Brittany Region (Grant ARED 1241 for Sacha Roudine and grant ARED 2355 for Lena Jego) and by the National Key R & D Project (2022YFD1400400), CAAS Projects (ZDRW202108) and the NSFC Project (31620103914).
Subjects: [SDV.BA]Life Sciences [q-bio]/Animal biology, Insect Science, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Ecology, Evolution, Behavior and Systematics
Abstract: International audience; One method to study the impact of climate change on host-parasitoid relationships is to compare populations along geographical gradients in latitude, altitude or longitude. Indeed, temperatures, which vary along geographic gradients directly shape the life traits of parasitoids and indirectly shift their populations through trophic interactions with hosts and plants. We explored the pros and cons of using these comparisons along gradients. We highlighted that the longitudinal gradients, although understudied, are well correlated to winter warming and summer heat waves and we draw attention to the impact of the increase in extreme events, which will probably be the determining parameters of the effect of climate change on host-parasitoid relationships.
Published: 2023
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43. Dual-gated single-molecule field-effect transistors beyond Moore’s law

Author: Linan Meng, Na Xin, Chen Hu, Hassan Al Sabea, Miao Zhang, Hongyu Jiang, Yiru Ji, Chuancheng Jia, Zhuang Yan, Qinghua Zhang, Lin Gu, Xiaoyan He, Pramila Selvanathan, Lucie Norel, Stéphane Rigaut, Hong Guo, Sheng Meng, Xuefeng Guo, Peking University [Beijing], Chinese Academy of Sciences [Beijing] (CAS), McGill University = Université McGill [Montréal, Canada], Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Nankai University (NKU), We acknowledge primary financial support from the National Key R&D Program of China (2017YFA0204901, 2021YFA1200101, 2016YFA0300902, and 2019YFA0308500), the National Natural Science Foundation of China (22150013, 21727806, 21933001, 51991344, 91850120, and 11934003), the Natural Science Foundation of Beijing (Z181100004418003 and 2222009), 'Strategic Priority Research Program (B)' of Chinese Academy of Sciences (Grant No. XDB330301), the University of Rennes 1, the CNRS and the Agence Nationale de la Recherche (RuOxLux-ANR-12-BS07-0010-01), the Natural Sciences and Engineering Research Council (NSERC) of Canada, and the Fonds de recherche du Quebec-Nature et technologies (FRQNT) of the Province of Quebec (H.G.), Frontiers Science Center for New Organic Matter at Nankai University (63181206) and the Tencent Foundation through the XPLORER PRIZE. The authors also thank the High-Performance Computing Centre of McGill University, CalcuQuebec, and Compute Canada for computation facilities., and ANR-12-BS07-0010,RuOxLux,Modulation redox de la luminescence à l'aide de complexes organométalliques du ruthénium associés à une unité luminescente(2012)
Subjects: Multidisciplinary, [CHIM]Chemical Sciences, General Physics and Astronomy, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Abstract: As conventional silicon-based transistors are fast approaching the physical limit, it is essential to seek alternative candidates, which should be compatible with or even replace microelectronics in the future. Here, we report a robust solid-state single-molecule field-effect transistor architecture using graphene source/drain electrodes and a metal back-gate electrode. The transistor is constructed by a single dinuclear ruthenium-diarylethene (Ru-DAE) complex, acting as the conducting channel, connecting covalently with nanogapped graphene electrodes, providing field-effect behaviors with a maximum on/off ratio exceeding three orders of magnitude. Use of ultrathin high-k metal oxides as the dielectric layers is key in successfully achieving such a high performance. Additionally, Ru-DAE preserves its intrinsic photoisomerisation property, which enables a reversible photoswitching function. Both experimental and theoretical results demonstrate these distinct dual-gated behaviors consistently at the single-molecule level, which helps to develop the different technology for creation of practical ultraminiaturised functional electrical circuits beyond Moore’s law.
Published: 2022
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44. Recombination time mismatch and spin dependent photocurrent at a ferromagnetic-metal/semiconductor tunnel junction

Author: Viatcheslav I. Safarov, Igor V. Rozhansky, Ziqi Zhou, Bo Xu, Zhongming Wei, Zhan-Guo Wang, Yuan Lu, Henri Jaffrès, Henri-Jean Drouhin, Laboratoire des Solides Irradiés (LSI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), LSI - Physique et Chimie des nano-objets (PCN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), A.F. Ioffe Physical-Technical Institute, Russian Academy of Sciences [Moscow] (RAS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), University of Chinese Academy of Sciences [Beijing] (UCAS), Key Laboratory of Semiconductor Materials Science (LSMS), Institute of semiconductors [Chinese Academy of Sciences - Beijing] (IOS), Chinese Academy of Sciences [Beijing] (CAS)-Chinese Academy of Sciences [Beijing] (CAS), Unité mixte de physique CNRS/Thales (UMPhy CNRS/THALES), THALES [France]-Centre National de la Recherche Scientifique (CNRS), Russian Science Foundation project no. 17-12-01182 (spin relaxation model), National Key R&D Program of China (2018YFB2200104)., ANR-10-LABX-0035,Nano-Saclay,Paris-Saclay multidisciplinary Nano-Lab(2010), ANR-19-CE24-0005,SIZMO2D,Injection/detection de spin à champ magnétique nul dans des dispositifs SpinOptroniques à base de Semiconducteurs 2D(2019), ANR-18-CE24-0017,FEOrgSpin,Contrôle ferroélectrique de la spinterface organique/ferromagnétique(2018), and ANR-11-IS10-0001,SISTER,Contrôle electrique de l'injection de spin dans les spin-LEDs par effet de spin-transfert sans champ magnétique(2011)
Subjects: [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], General Physics and Astronomy
Abstract: International audience; We report on carrier dynamics in a spin photodiode based on a ferromagnetic-metal–GaAs tunnel junction. We show that the helicity-dependent current is determined not only by the electron spin polarization and spin asymmetry of the tunneling but in great part by a dynamical factor resulting from the competition between tunneling and recombination in the semiconductor, as well as by a specific quantity: the charge polarization of the photocurrent. The two latter factors can be efficiently controlled through an electrical bias. Under longitudinal magnetic field, we observe a strong increase of the signal arising from inverted Hanle effect, which is a fingerprint of its spin origin. Our approach represents a radical shift in the physical description of this family of emerging spin devices.
Published: 2022
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45. [Review] Intelligent on-demand design of phononic metamaterials

Author: Jin, Yabin, He, Liangshu, Wen, Zhihui, Mortazavi, Bohayra, Guo, Hongwei, Torrent, Daniel, Djafari-Rouhani, Bahram, Rabczuk, Timon, Zhuang, Xiaoying, Li, Yan, Tongji University, School of Aerospace Engineering and Applied Mechanics, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Department of Biotechnology and Bioengineering, School of Chemical Engineering and Key Laboratory of Fujian Province for Biochemical Technology, Huaqiao University (HQU), Universitat Jaume I, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Physique - IEMN (PHYSIQUE - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Bauhaus-Universität Weimar, Tongii University (Department of Geotechnical Engineering), Institute of Vegetables and Flowers (IVF), Chinese Academy of Agricultural Sciences (CAAS), This work is supported by the National Key R&D Program of China (Grant Nos. 2020YFA0211402), the National Natural Science Foundation of China (11902223), the program for professor of special appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, the High-Level Foreign Expert Program, the Fundamental Research Funds for the Central Universities. D.T. acknowledges financial support through the 'Ramon y Cajal' fellowship, under Grant No. RYC-2016-21188, from the Ministry of Science, Innovation, and Universities, through Project No. RTI2018-093921-AC42 and from the Universitat Jaume I through Project No. UJI-A2018-08., test, and IEMN, Collection
Subjects: [SPI]Engineering Sciences [physics], machine learning, metamaterials, [SPI] Engineering Sciences [physics], hierarchical structure, inverse design, 2D materials, phononic crystals
Abstract: International audience; With the growing interest in the field of artificial materials, more advanced and sophisticated functionalities are required from phononic crystals and acoustic metamaterials. This implies a high computational effort and cost, and still the efficiency of the designs may be not sufficient. With the help of third-wave artificial intelligence technologies, the design schemes of these materials are undergoing a new revolution. As an important branch of artificial intelligence, machine learning paves the way to new technological innovations by stimulating the exploration of structural design. Machine learning provides a powerful means of achieving an efficient and accurate design process by exploring nonlinear physical patterns in high-dimensional space, based on data sets of candidate structures. Many advanced machine learning algorithms, such as deep neural networks, unsupervised manifold clustering, reinforcement learning and so forth, have been widely and deeply investigated for structural design. In this review, we summarize the recent works on the combination of phononic metamaterials and machine learning. We provide an overview of machine learning on structural design. Then discuss machine learning driven on-demand design of phononic metamaterials for acoustic and elastic waves functions, topological phases and atomic-scale phonon properties. Finally, we summarize the current state of the art and provide a prospective of the future development directions.
Published: 2022
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46. Breakup of the proton halo nucleus 8B near barrier energies

Author: Yang, Lin, Lin, C. J., Yamaguchi, H., Moro Muñoz, Antonio Matías, Ma, N. R., Wang, D. X., Cook, K. J., Mazzocco, M., Zhong, F. P., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, National Key R&D Program of China, National Natural Science Foundation of China, Continuous Basic Scientific Research, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía, and Korea government (MSIT)
Abstract: The dynamics of a nuclear open quantum system could be revealed in the correlations between the breakup fragments of halo nuclei. The breakup mechanism of a proton halo nuclear system is of particular interest as the Coulomb polarization may play an important role, which, however, remains an open question. Here we use a highly efficient silicon detector array and measure the correlations between the breakup fragments of 8B incident on 120Sn at near-barrier energies. The energy and angular correlations can be explained by a fully quantum mechanical method based on the state-of-the-art continuum discretized coupled channel calculations. The results indicate that, compared to the neutron halo nucleus 6He, 8B presents distinctive reaction dynamics: the dominance of the elastic breakup. This breakup occurs mainly via the short-lived continuum states, almost exhausts the 7Be yield, indicating the effect of Coulomb polarization on the proton halo state. The correlation information reveals that the prompt breakup mechanism dominates, occurring predominantly on the outgoing trajectory. We also show that, as a large environment, the continuum of 8B breakup may not significantly influence elastic scattering and complete fusion. National Key R&D Program of China 2018YFA0404404 National Natural Science Foundation of China U2167204, 12175314, 12235020, U18672122 Continuous Basic Scientific Research WDJC-2019-13 Leading Innovation Project LC192209000701, LC202309000201 Basic Scientific Research Program JCKY2020201C002 Ministerio de Ciencia e Innovación PID2020-114687GB-I00 Junta de Andalucía P20_01247 Korea government (MSIT) 2013M7A1A1075764, 2018R1A5A1025563
Published: 2022

47. Direct Femtosecond Laser Inscription of High-Order Bragg Gratings in Fluoroaluminate Glass Fiber

Author: Lin She, Niannian Xu, Pengfei Wang, Jiquan Zhang, Mo Liu, Nian Lv, Ruoning Wang, Zhenrui Li, Shijie Jia, Shunbin Wang, Gerald Farrell, Weimin Sun, National Natural Science Foundation of China, and National Key R&D Program of China
Subjects: femtosecond laser, Fiber Bragg gratings, Electrical and Electronic Engineering, Electrical and Computer Engineering, Atomic and Molecular Physics, and Optics, fluoroaluminate glass fiber
Abstract: This letter reports the fabrication of fiber Bragg gratings (FBGs) within in-house fabricated fluoroaluminate (AlF3) glass fibers using femtosecond (fs) laser inscription at 800 nm. The grating strength of the FBGs was investigated for different pulse energies and different orders, and a 3rd-order FBG with Bragg wavelength at 1557 nm was found to have the highest reflectivity of 99.5%. In addition, the reflectivity of the mid-IR grating peaks for different orders was also studied, and a 2nd-order FBG with a reflectivity of 98.8% was obtained at 2864 nm. Finally, the temperature characteristics of a mid-IR FBG were studied between 30 °C and 150 °C, showing a linear wavelength dependence and an excellent stability for the refractive index modulation. Such highly reflectivity FBGs in AlF3 fiber have significant potential for applications in the development of compact all-fiber mid-IR fiber lasers.
Published: 2022

48. Constructing a fine dispersion and chemical interface based on an electrostatic self-assembly and aqueous phase compound in GO/SiO2/SBR composites to achieve high-wear resistance in eco-friendly green tires

Author: Rui Zhang, Jiaye Li, Stephen Jerrams, Shui Hu, Li Liu, Shipeng Wen, Liqun Zhang, and This work was supported by the National Key R&D Program of China, China (2017YFE0126800) and the National Natural Science Foundation of China, China (51790504).
Subjects: Materials Science and Engineering, General Chemical Engineering, Polymer and Organic Materials, Environmental Chemistry, Rubber, General Chemistry, Interface, Dispersion, Abrasion resistance, Chemical Engineering, Industrial and Manufacturing Engineering, Graphene oxide
Abstract: The hazard to the ecosystem caused by rubber microparticles generated from tire abrasion has been a constant concern. Therefore, to protect this ecosystem, the development of a tire tread with high abrasion resistance is especially significant. Herein, γ-aminopropyltriethoxysilane (APTES) was used to modify graphene oxide (GO) and silica (SiO2) to obtain GO and SiO2 with positive charges (NG and NS). Furthermore, NG and NS were electrostatically self-assembled by using maleic anhydride (MAH) hydrolysis, thereby obtaining composite particles (NG-NS) with “bridged structures”. Also, the NG-NS/styrene butadiene rubber (SBR) compounds possessing fine dispersion of NG-NS were prepared by the aqueous compounding method. During the crosslinking process, the vinyl groups in NG-NS reacted with the vinyl groups of the SBR molecule chains, thus forming strong chemical interfacial interactions between the NG-NS and rubber macromolecules. Compared with an SiO2/SBR composite, the 300 % modulus, tensile strength, abrasion resistance of the NG-NS/SBR composite were improved by 125 %, 122 %, 83.3 %, respectively. Compared with a GO/SiO2/SBR composite, heat build-up in the NG-NS/ SBR was decreased by 8.2 ◦C.
Published: 2023
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49. Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum

Author: Xinyu Yu, Changhong Wang, Yuemeng Zhao, Jianxia Tang, Meng Zhu, Lucien Platon, Richard Culleton, Guoding Zhu, Didier Ménard, Qingfeng Zhang, Jun Cao, Soochow University, Jiangsu Institute of Parasitic Diseases, Nanjing University (NJU), Tongji University, Génétique du paludisme et résistance - Malaria Genetics and Resistance, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), ED 515 - Complexité du vivant, Sorbonne Université (SU), Ehime University [Matsuyama, Japon], Dynamique des interactions hôte pathogène (DIHP), Université de Strasbourg (UNISTRA), CHU Strasbourg, and This work was supported by National Key R&D Program of China (No. 2020YFC1200105 and 2018YFA0507300), National Natural Science Foundation of China (No. 82230077, 81971967, 82102424, 81971959, and 82172302), Natural Science Foundation of Jiangsu Province (No. BK20210061), the China Postdoctoral Science Foundation (2020M671397), the Shanghai Blue Cross Brain Hospital Co. Ltd., and Shanghai Tongji University Education Development Foundation.
Subjects: Multidisciplinary, [SDV]Life Sciences [q-bio]
Abstract: International audience; The emergence and spread of artemisinin-tolerant malaria parasites threatens malaria control programmes worldwide. Mutations in the propeller domain of the Kelch13 protein confer Plasmodium falciparum artemisinin resistance (ART-R). ART-R is linked to the reduced susceptibility of temporary growth-arrested ring-stage parasites, but the metabolic mechanisms remain elusive. We generated two PfKelch13 mutant lines via CRISPR-Cas9 gene editing which displayed a reduced susceptibility accompanied by an extended ring stage. The metabolome of ART-induced ring-stage growth arrest parasites carrying PfKelch13 mutations showed significant alterations in the tricarboxylic acid (TCA) cycle, glycolysis, and amino acids metabolism, pointing to altered energy and porphyrin metabolism with metabolic plasticity. The critical role of these pathways was further confirmed by altering metabolic flow or through chemical inhibition. Our findings uncover that the growth arrestment associated with ART-R is potentially attributed to the adaptative metabolic plasticity, indicating that the defined metabolic remodeling turns out to be the trigger for ART-R.
Published: 2023
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50. Investigation of two neural mass models for DCM-based effective connectivity inference in temporal epilepsy

Author: Wentao Xiang, Ahmad Karfoul, Chunfeng Yang, Huazhong Shu, Régine Le Bouquin Jeannès, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nanjing Medical University, Centre de Recherche en Information Biomédicale sino-français (CRIBS), Université de Rennes (UR)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Image Science and Technology [Nanjing] (LIST), Southeast University [Jiangsu]-School of Computer Science and Engineering, This work has been supported by Natural Science Foundation of China under Grant (62001240, 31400842, 61876037), the National Key Research and Development Program of China (2017YFB1303200), the National Key R&D Program of China (2017YFC0107900), the CRIBs, the Leading-edge Technology and Basic Research Program of Jiangsu Province (BK20192004) and the China Scholarship Council., Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Epilepsy, Models, Neurological, Brain, Health Informatics, Electroencephalography, Models, Theoretical, Computer Science Applications, Spectral dynamic causal modelling, Power spectral density, Seizures, Gamma Rhythm, Humans, Neural mass model, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Nerve Net, Effective connectivity, Software
Abstract: International audience; BACKGROUND AND OBJECTIVE: Recently, spectral Dynamic Causal Modelling (DCM) has been used increasingly to infer effective connectivity from epileptic intracranial electroencephalographic (iEEG) signals. In this context, the Physiology-Based Model (PBM), a neural mass model, is used as a generative model. However, previous studies have highlighted out the inability of PBM to properly describe iEEG signals with specific power spectral densities (PSDs). More precisely, PSDs that have multiple peaks around β and γ rhythms (i.e. spectral characteristics at seizure onset) are concerned. METHODS: To cope with this limitation, an alternative neural mass model, called the complete PBM (cPBM), is investigated. The spectral DCM and two recent variants are used to evaluate the relevance of cPBM over PBM. RESULTS: The study is conducted on both simulated signals and real epileptic iEEG recordings. Our results confirm that, compared to PBM, cPBM shows (i) more ability to model the desired PSDs and (ii) lower numerical complexity whatever the method. CONCLUSIONS: Thanks to its intrinsic and extrinsic connectivity parameters as well as the input coming into the fast inhibitory subpopulation, the cPBM provides a more expressive model of PSDs, leading to a better understanding of epileptic patterns and DCM-based effective connectivity inference.
Published: 2021
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