1. Managing noradrenaline after traumatic brain injury.
- Author
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Hussain, Rashad and Nedergaard, Maiken
- Subjects
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BRAIN injuries , *EPILEPSY , *NORADRENALINE , *SPASTICITY , *ALZHEIMER'S disease - Abstract
Traumatic brain injury (TBI) is a significant global health issue, causing death and disability in young adults. One of the complications of TBI is cerebral edema, which can lead to increased mortality and disability. Noradrenaline (NA) has been commonly used to treat TBI patients, but its role in cerebral edema was not well understood. A recent study using a mouse model found that blocking adrenergic receptors reduced cerebral edema and improved neurological function. The study also highlighted the importance of lymphatic drainage in TBI and suggested that noradrenergic inhibition could enhance glymphatic/lymphatic function. While more research is needed, these findings provide mechanistic insights into the benefits of pan-adrenergic blockage in TBI. [Extracted from the article]
- Published
- 2024
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