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562 results on '"O'Driscoll K"'

15. 1292P A review of in-hospital end-of-life care (EOLC) for oncology patients during the COVID-19 pandemic

Author

Carroll, H.K., primary, Broderick, A., additional, McCarthy, O., additional, Kennedy, M., additional, Bambury, R., additional, Power, D.G., additional, Collins, D.C., additional, Connolly, R.M., additional, Noonan, S.A., additional, Collins, D., additional, Cunningham, E., additional, O'Driscoll, K., additional, Nuzum, D., additional, Twomey, K., additional, O'Riordan, A., additional, O'Sullivan, F., additional, Roe, C., additional, O'Leary, M.J., additional, Lowney, A.C., additional, and O'Reilly, S., additional

Published
2022
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19. Ten years of a publicly funded homebirth service in Victoria: Maternal and neonatal outcomes

Author

Sweet, L, Wynter, K, O'Driscoll, K, Blums, T, Nenke, A, Sommeling, M, Kolar, R, Teale, G, Sweet, L, Wynter, K, O'Driscoll, K, Blums, T, Nenke, A, Sommeling, M, Kolar, R, and Teale, G

Abstract

BACKGROUND: Rates of homebirth in Australia remain low, at less than 0.3% of all births. AIMS: To report maternal and neonatal outcomes of ten years of a publicly funded homebirth service, 2009-2019. METHOD: Retrospective analysis of clinical outcome data including neonatal outcomes of women who requested a homebirth at a large metropolitan health service in Victoria, Australia. The primary outcomes included: maternal outcomes (mortality, transfer to hospital, place and mode of birth, perineal status, type of third stage of labour, postpartum haemorrhage), and neonatal outcomes (mortality, Apgar score at five minutes, birthweight, breastfeeding initiation, significant morbidity, transfer to hospital). RESULTS: Referrals for 827 women were reviewed; 633 remained eligible at 36 weeks gestation, and 473 (57%) birthed at home. Compared to women who did not, women who had a homebirth were significantly more likely to be multiparous, have a normal vaginal birth and an intact perineum, less likely to require suturing and less likely to have blood loss of more than 500 mL. Compared to infants not born at home, infants born at home were significantly less likely to require resuscitation, more likely to be of normal birthweight and exclusively receive breastmilk on discharge. There were no maternal deaths and one neonatal death of a baby born at home before the arrival of a midwife. CONCLUSIONS: The outcomes for women accepted into the publicly funded homebirth program suggest appropriate triaging and case selection. A publicly funded homebirth program, with appropriate governance and clinical guidelines, appears to be a safe option for women experiencing low-risk pregnancies.

Published
2022

29. Spatial localization and properties of pacemaker potentials in the canine rectoanal region

Author

Mutafova-Yambolieva, V.N., O'Driscoll, K., Farrelly, A., Ward, S.M., and Keef, K.D.

Subjects
Rectum -- Physiological aspects, Smooth muscle -- Physiological aspects, Gastrointestinal system -- Motility, Biological sciences
Abstract

The present study investigated the spatial organization of electrical activity in the canine rectoanal region and its relationship to motility patterns. Contraction and resting membrane potential ([E.sub.m]) were measured from strips of circular muscle isolated 0.5-8 cm from the anal verge. Rapid frequency [25 cycles/min (cpm)] [E.sub.m] oscillations (MPOs, 12 mV amplitude) were present across the thickness of the internal anal sphincter (IAS; 0.5 cm) and [E.sub.m] was constant (-52 mV). Between the IAS and the proximal rectum an 18 mV gradient in [E.sub.m] developed across the muscle thickness with the submucosal edge at -70 mV and MPOs were replaced with slow waves (20 mV amplitude, 6 cpm). Slow waves were of greatest amplitude at the submucosal edge. Nifedipine (1 [micro]M) abolished MPOs but not slow waves. Contractile frequency changes were commensurate with the changes in pacemaker frequency. Our results suggest that changing motility patterns in the rectoanal region are associated with differences in the characteristics of pacemaker potentials as well as differences in the sites from which these potentials emanate. interstitial cells of Cajal; smooth muscle; membrane potential; internal anal sphincter; rectum

Published
2003

32. Electrical activity induced by nitric oxide in canine colonic circular muscle

Author

Keef, K.D., Anderson, U., O'Driscoll, K., Ward, S.M., and Sanders, K.M.

Subjects
Physiology -- Research, Dogs -- Physiological aspects, Colon (Anatomy) -- Physiological aspects, Nitric oxide -- Physiological aspects, Smooth muscle -- Physiological aspects, Nervous system -- Physiological aspects, Biological sciences
Abstract

Electrical activity induced by nitric oxide in canine colonic circular muscle. Am J Physiol Gastrointest Liver Physiol 282: G123-G129, 2002; 10.1152/ ajpgi.00217.2001.--Nitric oxide generates slow electrical oscillations (SEOs) in cells near the myenteric edge of the circular muscle layer, which resemble slow waves generated by interstitial cells of Cajal (ICCs) at the submucosal edge of this muscle. The properties of SEOs were studied to determine whether these events are similar to slow waves. Rapid frequency membrane potential oscillations (MPOs; 16 [+ or -] 1 cycles/min and 9.6 [+ or -] 0.2 mV) were recorded from control muscles near the myenteric edge. Sodium nitroprusside (0.3 [micro]M) reduced MPOs and initiated SEOs (1.3 [+ or -] 0.3 cycles/min and 13.4 [+ or -] 1.4 mV amplitude). SEOs were abolished by the guanylate cyclase inhibitor 1H-[1,2,4]-oxadiazolo-[4,3-a]-quinoxaline-1-one (10 [micro]M). MPOs were abolished by nifedipine (1 [micro]M), whereas SEO frequency increased and the amount of depolarization decreased. BAY K 8644 (1 [micro]M) prolonged SEOs and reduced their frequency. SEOs were abolished by [Ni.sup.2+] (0.5 mM), low [Ca.sup.2+] solution (0.1 mM [Ca.sup.2+]), cyclopiazonic acid (10 [micro]M), and the mitochondrial uncouplers antimycin (10 [micro]M) and carbonyl cyanide p-trifluoromethoxyphenylhydrazone (1 [micro]M). Oligomycin (10 [micro]M) was without effect. These effects are similar to those described for colonic slow waves. Our results suggest that nitric oxide-induced SEOs are similar in mechanism to slow waves, an activity not previously thought to be generated by myenteric pacemakers. smooth muscle; interstitial cells of Cajal; slow wave; colonic motility; enteric nervous system

Published
2002

36. Irish neurological association: Proceedings of 28th annual meeting, beaumont hospital, Dublin, 15th-16th may, 1992

Author

Sakas, D. E., O’Connor, G., Singh, J., Dias, L., Eljamel, M. S., Mathew, B., Clements, B., Irvine, A., Gray, W. J., Byrnes, D. P., Bailey, I. C., Pathirana, N., Refsum, S., Bell, K. E., McKinstry, C. S., Callaghan, N., Crowley, M., Goggin, T., MacDermott, N., O’Driscoll, K. J., Neary, D., Pearson, N. A., Snowden, J. S., Brown, S., Vaughan, M., McMackin D., Phillips J., Burke T., Murphy S., Staunton H., Cristea, R. L., Hourihane, M., Farrell, M. A., Morrison, P. J., Nevin, N. C., Collins, A. D., Gibson, M., Behan, W. M. H., Simpson, K. S., Cavanagh, H. M., Gow, J. W., Gillespie, J. S., Behan, P. O., Sklar, R. M., Brown, R. H., Gillian, A. M., O’Mahony, D., Breen, K. C., Hutchinson, J., Burke, T., Hutchinson, M., Droogan, A. G., Crockard, A. D., Hawkins, S. A., McNeill, T. A., Gutowski, N. J., Chirico, S., Pinkham, J. M., Smith, C., Akanu, D., Kaur, H., Strange, R. C., Halliwell, B., Murphy, R. P., Rogers, L., Weick, J., Estes, M., Elrington, G. M., Morris, C. S., Reffin, J. P., Tregear, S. J., Ripley, L. J., Rees, J. E., Irvine, A. D., O’Brien, D. P., Dias, P. S., Herity, N., Hawkins, S., McMenamin, J. B., Mirakhur, M., Allen, I. V., Bresnihan, B., Fitzsimmons, M., Sawhney, B., Patterson, V., Bailey, I. C., Byrnes, D., Watt, M., Lee, Kui-Chung, Redmond, J. M. T., McKenna, M. J., Feingold, M., Ahmad, B. K., Watt, M., Cunningham, R. T., Winder, J., Lawson, J. A., Johnston, C. F., Buchanan, K. D., Dean, G., Elian, M., Gray, W. P., Ryder, D. Q., Buckley, T. F., Breathnach, K., Ooi, A., Farrell, M., Doherty, C., Hayes, F. J., Redmond, J. J. T., McKenna, M. M., Redmond, J. M. T., Farrell, M., Watt, M., Gibson, J. M., Patterson, V. H., Redmond, J. M. T., McKenna, M. J., Feingold, M., Ahmad, B. K., Moran, M., Burke, M., King, M. D., Moran, M., Burke, M., Hardiman, O., Reid, V., Dowd, J. O., Murphy, R., Rashad, E., Toland, J., Phillips, J. P., Staunton, H., Shu-Ming, Peng, Coughlin, A., Phillips, J. P., McCoy, D. M., Qureshi, A., Black, M. A., Grace, P. A., Bouchier-Hayes, D., and Dwyer, R.

Published
1993
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37. Royal Academy Of Medicine In Ireland Section Of Ophthalmology: Proceedings of meeting held 19th & 20th April 1991 in Galway

Author

Fenton, M., O’Connor, M., Khan, W. A., Condon, P. I., Coffey, M., Curtin, D. McAuliffe, Horgan, T., Sharkey, J. A., O’Brien, C., Grierson, I., McAllister, J., Beigi, B., O’Driscoll, K., Hone, R., Firth, R., Eustace, P., Brady, K., Mooney, D., Walsh, J., Early, O., Best, R., McQuaid, M., Gardiner, T., Chakravarthy, U., Archer, D. B., Dwyer, M. Hickey, Duvall-Young, J., Brown, M., Lacy, C., Power, W. J., Collum, L. M. T., Fenton, J., Kelly, S. P., McLeod, D., O’Donnell, N. P., Batterbury, M., and O’Donoghue, E. P.

Published
1992
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38. Protein kinase C isozymes epsilon and alpha in murine erythroleukemia cells

Author

Powell, C. T., Leng, L., Dong, L., Busquets, X., O'Driscoll, K., Marks, P. A., and Rifkind, R. A.

Subjects
Protein kinases -- Research, Isoenzymes -- Research, Erythrocytes -- Analysis, Erythrocyte disorders -- Research, Science and technology
Abstract

Murine erythroleukemia cells contained the protein kinase C (PKC) epsilon and alpha isoenzymes but no PKC beta isoenzymes. Hydroxylapatite column chromatography separated the different Ca2+-dependent isoenzymes and showed major and minor peaks of PKC activity. Immunoblot analysis using antibodies specific for PKCalpha and PCKepsilon revealed that the the minor peak contained PKCepsilon and not PKCbeta as previously identified while the major peak was noted to be predominated by PKCalpha.

Published
1992

44. Monte Carlo Calculation of Sequence Distributions in Polymers

Author

Motoc, I., O’Driscoll, K. F., Berthier, Gaston, editor, Dewar, Michael J. S., editor, Fischer, Hanns, editor, Fukui, Kenichi, editor, Hall, George G., editor, Hartmann, Hermann, editor, Jaffé, Hans H., editor, Jortner, Joshua, editor, Kutzelnigg, Werner, editor, Ruedenberg, Klaus, editor, Scrocco, Eolo, editor, Bruns, Wolfgang, Motoc, Ioan, and O’Driscoll, Kenneth F.

Published
1981
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47. Stimulation of HIV-specific T cell clonotypes using allogeneic HLA

Author

Almeida, C., van Miert, P., O'Driscoll, K., Zoet, Y.M., Chopra, A., Watson, M., de Santis, D., Witt, C., John, M., Claas, F.H.J., D'Orsogna, L.J., Almeida, C., van Miert, P., O'Driscoll, K., Zoet, Y.M., Chopra, A., Watson, M., de Santis, D., Witt, C., John, M., Claas, F.H.J., and D'Orsogna, L.J.

Abstract

We hypothesized that HIV-specific CD8 T cell clonotypes can be stimulated by allogeneic HLA molecules. Multiple HIV-specific CD8 T cell clones were derived from 12 individuals with chronic HIV infection, specific for 13 different HIV Gag antigens and restricted to 7 different HLA molecules. The generated T cell clones were assayed for alloreactivity against a panel of single HLA class I expressing cell lines (SALs). HIV-specific T cells recognising at least one allogeneic HLA molecule could be identified from 7 of 12 patients tested. Allorecognition was associated with IFNγ cytokine production, CD137 upregulation and cytotoxicity, suggesting high avidity allo-stimulation. Allo-HLA recognition by HIV-specific T cells was specific to the HIV target peptide/HLA restriction and TCR TRBV usage of the T cells. HIV-specific T cells do crossreact against allogeneic HLA molecules in an epitope and TRBV specific manner. Therefore allo-HLA stimulation could be exploited to induce or augment HIV-specific T cell responses.

Published
2017

48. Climate variability drives anchovies and sardines into North Sea and Baltic Sea

Author

Alheit J, Pohlmann T, Casini M, Greve W, Hinrichs R, Mathis M, O'Driscoll K, Vorberg R, Wagner C, Alheit J, Pohlmann T, Casini M, Greve W, Hinrichs R, Mathis M, O'Driscoll K, Vorberg R, and Wagner C

Subjects
Range expansion, climate, pelagic fish
Abstract

European anchovy (Engraulis encrasicolus) and sardine (Sardina pilchardus) are southern, warm water species that prefer temperatures warmer than those found in boreal waters. After about 40 years of absence, they were again observed in the 1990s in increasing quantities in the North Sea and the Baltic Sea. Whereas global warming probably played a role in these northward migrations, the North Atlantic Oscillation (NAO), the Atlantic Multidecadal Oscillation (AMO) and the contraction of the subpolar gyre were important influences. Sardine re-invaded the North Sea around 1990, probably mainly as a response to warmer temperatures associated with the strengthening of the NAO in the late 1980s. However, increasing numbers of anchovy eggs, larvae, juveniles and adults have been recorded only since the mid-1990s, when, particularly, summer temperatures started to increase. This is probably a result of the complex dynamics of ocean–atmosphere coupling involving changes in North Atlantic current structures, such as the contraction of the subpolar gyre, and dynamics of AMO. Apparently, climate variability drives anchovies and sardines into the North and Baltic Seas. Here, we elucidate the climatic background of the return of anchovies and sardines to the northern European shelf seas and the changes in the North Sea fish community in the mid-1990s in response to climate variability.

Published
2012

49. Liquid paraffin: a reappraisal of its role in the treatment of constipation

Author

Sharif, F, Crushell, E, O'Driscoll, K, and Bourke, B

Subjects
Mineral oils -- Health aspects, Constipation -- Care and treatment, Family and marriage, Health, Care and treatment, Health aspects
Abstract

Liquid paraffin or mineral oil is a transparent, colourless, odourless, or almost odourless, oily liquid composed of saturated hydrocarbons obtained from petroleum. [1] Petroleum was used as a medicine at [...]

Published
2001

50. Significance of white matter abnormalities in patients with closed head injury

Author

Sobhan Vinjamuri and O'Driscoll K

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Glasgow Outcome Scale, Context (language use), Central nervous system disease, White matter, Disability Evaluation, Neuroimaging, Head Injuries, Closed, Activities of Daily Living, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Tomography, Emission-Computed, Single-Photon, medicine.diagnostic_test, business.industry, Brain, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Treatment Outcome, medicine.anatomical_structure, Cerebral blood flow, Cerebrovascular Circulation, Closed head injury, Female, Radiology, business, Nuclear medicine, Perfusion
Abstract

Neuroimaging in patients with closed head injury (CHI) may frequently reveal abnormalities of white matter. Because white matter abnormalities may be seen in patients aged over 40 years even without CHI, the significance of these abnormalities in patients with CHI is questionable and needs to be assessed in the context of relevance to clinical outcome. The aims of this study were to determine the relative incidence of white matter abnormalities in a group of patients with CHI, and to assess the impact (if any) of these abnormalities on clinical outcome. Sixty-three patients with CHI underwent neuroimaging with magnetic resonance imaging (MRI) and regional cerebral blood flow (rCBF) single photon emission tomography (SPET) approximately 6 months after trauma. Seven patients had white matter abnormalities on MRI scanning. There are no rCBF SPET criteria for defining abnormal perfusion to the white matter. The SPET scans ranged from normal (one patient) and abnormal perfusion to frontal, temporal or parietal lobes in these patients (n = 6). Patients were assessed for outcome after undergoing appropriate rehabilitation programmes with indices of reintegration into the community, activities of daily living, disability, and their cognitive ability to perform tasks. This assessment was conducted 2 years after initial trauma. Of these seven patients with abnormal MRI of the white matter, one performed poorly and six had moderate to good clinical outcome. When individual lobar perfusion is considered, abnormal perfusion to the frontal or temporal lobes was significantly associated with poorer outcome (P < 0.005). In conclusion, white matter abnormalities detected by MRI are frequently associated with cortical perfusion defects identified by SPET (6/7 or 86%). However, when these white matter abnormalities were accompanied by perfusion defects in the frontal and temporal lobes, these were statistically significant in predicting poorer outcome.

Published
2000
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