Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:56:57Z No. of bitstreams: 1 S0102-311X2005000200025.pdf: 71731 bytes, checksum: e86bfed7005fe046271e98d27538de86 (MD5) Made available in DSpace on 2013-08-22T18:56:57Z (GMT). No. of bitstreams: 1 S0102-311X2005000200025.pdf: 71731 bytes, checksum: e86bfed7005fe046271e98d27538de86 (MD5) Previous issue date: 2005-04-01 Made available in DSpace on 2013-09-30T18:23:36Z (GMT). No. of bitstreams: 2 S0102-311X2005000200025.pdf: 71731 bytes, checksum: e86bfed7005fe046271e98d27538de86 (MD5) S0102-311X2005000200025.pdf.txt: 35567 bytes, checksum: c2036656b348785ede1cd0c60409e940 (MD5) Previous issue date: 2005-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:38:05Z No. of bitstreams: 2 S0102-311X2005000200025.pdf: 71731 bytes, checksum: e86bfed7005fe046271e98d27538de86 (MD5) S0102-311X2005000200025.pdf.txt: 35567 bytes, checksum: c2036656b348785ede1cd0c60409e940 (MD5) Made available in DSpace on 2014-05-20T13:38:05Z (GMT). No. of bitstreams: 2 S0102-311X2005000200025.pdf: 71731 bytes, checksum: e86bfed7005fe046271e98d27538de86 (MD5) S0102-311X2005000200025.pdf.txt: 35567 bytes, checksum: c2036656b348785ede1cd0c60409e940 (MD5) Previous issue date: 2005-04-01 Este estudo avalia os fatores maternos e fetais envolvidos na transmissão vertical do HIV-1 em 47 pares de mãe e filho. As variáveis comportamentais, demográficas e obstétricas foram obtidas mediante entrevista; os dados referentes ao parto e ao recém-nascido, dos prontuários das maternidades. Durante o terceiro trimestre de gestação foi realizada a contagem da carga viral materna e dos linfócitos T CD4+. A média de idade foi de 25 anos e 23,4% das gestantes eram primigestas, e o fator comportamental mais prevalente foi não usar preservativos. Dentre as gestantes, 48,9% tinham células CD4+ superior a 500 células/mm³ e 93,6% se enquadravam na categoria clínica A; 95,7% submeteram-se à profilaxia com zidovudina durante a gestação ou no parto, a qual foi ministrada a todos os recém-nascidos; 50,0% delas foram submetidas à cesárea eletiva. Apesar de expostas a vários fatores de risco e protetores, nenhuma criança tornou-se infectada. A transmissão vertical resulta de um desequilíbrio entre os fatores, com predomínio dos de risco sobre os protetores. This study aimed to evaluate maternal and fetal factors related to vertical transmission of HIV-1. Participants included 47 mother-child pairs. Behavioral, demographic, and obstetric data were obtained through interviews. Data related to delivery and newborns were collected from registries in the maternity hospitals. During the third trimester of pregnancy, CD4+ T lymphocytes and maternal viral load were measured. Mean age of the mothers was 25 years and 23.4% of the pregnant women were primigravidae. The most prevalent behavioral factor was lack of condom use. 48.9% of the women presented a CD4+ count greater than 500 cells/ mm³, and 93.6% belonged to clinical category A. 95.7% of the women received zidovudine prophylaxis during pregnancy or childbirth, and the medication was also administered to all the neonates. 50.0% of patients were submitted to elective cesareans. Despite several risk and protective factors, none of the children was infected. Vertical transmission is an outcome of an imbalance among factors, with a predominance of risk over protective factors. Universidade de Marília Departamento de Pediatria Universidade Estadual Paulista Departamento de Pediatria Faculdade de Medicina de Botucatu Universidade Estadual Paulista Departamento de Pediatria Faculdade de Medicina de Botucatu