Search

Your search keyword '"Oddsson A"' showing total 1,663 results
Start Over Author "Oddsson A"
1,663 results on '"Oddsson A"'

1. Gene-based burden tests of rare germline variants identify six cancer susceptibility genes

Author

Ivarsdottir, Erna V., Gudmundsson, Julius, Tragante, Vinicius, Sveinbjornsson, Gardar, Kristmundsdottir, Snaedis, Stacey, Simon N., Halldorsson, Gisli H., Magnusson, Magnus I., Oddsson, Asmundur, Walters, G. Bragi, Sigurdsson, Asgeir, Saevarsdottir, Saedis, Beyter, Doruk, Thorleifsson, Gudmar, Halldorsson, Bjarni V., Melsted, Pall, Stefansson, Hreinn, Jonsdottir, Ingileif, Sørensen, Erik, Pedersen, Ole B., Erikstrup, Christian, Bøgsted, Martin, Pøhl, Mette, Røder, Andreas, Stroomberg, Hein Vincent, Gögenur, Ismail, Hillingsø, Jens, Bojesen, Stig E., Lassen, Ulrik, Høgdall, Estrid, Ullum, Henrik, Brunak, Søren, Ostrowski, Sisse R., Sonderby, Ida Elken, Frei, Oleksandr, Djurovic, Srdjan, Havdahl, Alexandra, Moller, Pal, Dominguez-Valentin, Mev, Haavik, Jan, Andreassen, Ole A., Hovig, Eivind, Agnarsson, Bjarni A., Hilmarsson, Rafn, Johannsson, Oskar Th., Valdimarsson, Trausti, Jonsson, Steinn, Moller, Pall H., Olafsson, Jon H., Sigurgeirsson, Bardur, Jonasson, Jon G., Tryggvason, Geir, Holm, Hilma, Sulem, Patrick, Rafnar, Thorunn, Gudbjartsson, Daniel F., and Stefansson, Kari

Published
2024
Full Text
View/download PDF

2. Genetic links between ovarian ageing, cancer risk and de novo mutation rates

Author

Stankovic, Stasa, Shekari, Saleh, Huang, Qin Qin, Gardner, Eugene J., Ivarsdottir, Erna V., Owens, Nick D. L., Mavaddat, Nasim, Azad, Ajuna, Hawkes, Gareth, Kentistou, Katherine A., Beaumont, Robin N., Day, Felix R., Zhao, Yajie, Jonsson, Hakon, Rafnar, Thorunn, Tragante, Vinicius, Sveinbjornsson, Gardar, Oddsson, Asmundur, Styrkarsdottir, Unnur, Gudmundsson, Julius, Stacey, Simon N., Gudbjartsson, Daniel F., Kennedy, Kitale, Wood, Andrew R., Weedon, Michael N., Ong, Ken K., Wright, Caroline F., Hoffmann, Eva R., Sulem, Patrick, Hurles, Matthew E., Ruth, Katherine S., Martin, Hilary C., Stefansson, Kari, Perry, John R. B., and Murray, Anna

Published
2024
Full Text
View/download PDF

3. Homozygosity for a stop-gain variant in CCDC201 causes primary ovarian insufficiency

Author

Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Oskarsson, Gudjon R., Styrkarsdottir, Unnur, Moore, Kristjan H. S., Isberg, Salvor, Halldorsson, Gisli H., Sveinbjornsson, Gardar, Westergaard, David, Nielsen, Henriette Svarre, Fridriksdottir, Run, Jensson, Brynjar O., Arnadottir, Gudny A., Jonsson, Hakon, Sturluson, Arni, Snaebjarnarson, Audunn S., Andreassen, Ole A., Walters, G. Bragi, Nyegaard, Mette, Erikstrup, Christian, Steingrimsdottir, Thora, Lie, Rolv T., Melsted, Pall, Jonsdottir, Ingileif, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Saemundsdottir, Jona, Magnusson, Olafur Th., Banasik, Karina, Sorensen, Erik, Masson, Gisli, Pedersen, Ole Birger, Tryggvadottir, Laufey, Haavik, Jan, Ostrowski, Sisse Rye, Stefansson, Hreinn, Holm, Hilma, Rafnar, Thorunn, Gudbjartsson, Daniel F., Sulem, Patrick, and Stefansson, Kari

Published
2024
Full Text
View/download PDF

4. The correlation between CpG methylation and gene expression is driven by sequence variants

Author

Stefansson, Olafur Andri, Sigurpalsdottir, Brynja Dogg, Rognvaldsson, Solvi, Halldorsson, Gisli Hreinn, Juliusson, Kristinn, Sveinbjornsson, Gardar, Gunnarsson, Bjarni, Beyter, Doruk, Jonsson, Hakon, Gudjonsson, Sigurjon Axel, Olafsdottir, Thorunn Asta, Saevarsdottir, Saedis, Magnusson, Magnus Karl, Lund, Sigrun Helga, Tragante, Vinicius, Oddsson, Asmundur, Hardarson, Marteinn Thor, Eggertsson, Hannes Petur, Gudmundsson, Reynir L., Sverrisson, Sverrir, Frigge, Michael L., Zink, Florian, Holm, Hilma, Stefansson, Hreinn, Rafnar, Thorunn, Jonsdottir, Ingileif, Sulem, Patrick, Helgason, Agnar, Gudbjartsson, Daniel F., Halldorsson, Bjarni V., Thorsteinsdottir, Unnur, and Stefansson, Kari

Published
2024
Full Text
View/download PDF

5. Brief communication: Small-scale geohazards cause significant and highly variable impacts on emotions

Author

E. Ilyinskaya, V. Snæbjarnarson, H. K. Carlsen, and B. Oddsson

Subjects
Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract

The impact of geohazards on the mental health of local populations is well recognised but understudied. We used natural language processing (NLP) of Twitter (now known as X) posts (n=10 341) to analyse the sentiments expressed in relation to a pre-eruptive seismic unrest and a subsequent volcanic eruption in Iceland in 2019–2021. We show that although these geohazards were of a small size and caused negligible material damage, they were associated with a measurable change in expressed emotions in the local population. The seismic unrest was associated with predominantly negative sentiments (positive-to-negative sentiment ratio of 1:1.3), but the eruption was associated with predominantly positive sentiments (positive-to-negative sentiment ratio of 1.4:1). We demonstrate a cost-effective tool for gauging public discourse that could be used in risk management.

Published
2024
Full Text
View/download PDF

6. Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease

Author

Saevarsdottir, Saedis, Bjarnadottir, Kristbjörg, Markusson, Thorsteinn, Berglund, Jonas, Olafsdottir, Thorunn A., Halldorsson, Gisli H., Rutsdottir, Gudrun, Gunnarsdottir, Kristbjorg, Arnthorsson, Asgeir Orn, Lund, Sigrun H., Stefansdottir, Lilja, Gudmundsson, Julius, Johannesson, Ari J., Sturluson, Arni, Oddsson, Asmundur, Halldorsson, Bjarni, Ludviksson, Björn R., Ferkingstad, Egil, Ivarsdottir, Erna V., Sveinbjornsson, Gardar, Grondal, Gerdur, Masson, Gisli, Eldjarn, Grimur Hjorleifsson, Thorisson, Gudmundur A., Kristjansdottir, Katla, Knowlton, Kirk U., Moore, Kristjan H. S., Gudjonsson, Sigurjon A., Rognvaldsson, Solvi, Knight, Stacey, Nadauld, Lincoln D., Holm, Hilma, Magnusson, Olafur T., Sulem, Patrick, Gudbjartsson, Daniel F., Rafnar, Thorunn, Thorleifsson, Gudmar, Melsted, Pall, Norddahl, Gudmundur L., Jonsdottir, Ingileif, and Stefansson, Kari

Published
2024
Full Text
View/download PDF

7. Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination

Author

Steinthorsdottir, Valgerdur, Halldorsson, Bjarni V., Jonsson, Hakon, Palsson, Gunnar, Oddsson, Asmundur, Westergaard, David, Arnadottir, Gudny A., Stefansdottir, Lilja, Banasik, Karina, Esplin, M. Sean, Hansen, Thomas Folkmann, Brunak, Søren, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Erikstrup, Christian, Thorleifsson, Gudmar, Nadauld, Lincoln D., Haraldsson, Asgeir, Steingrimsdottir, Thora, Tryggvadottir, Laufey, Jonsdottir, Ingileif, Gudbjartsson, Daniel F., Hoffmann, Eva R., Sulem, Patrick, Holm, Hilma, Nielsen, Henriette Svarre, and Stefansson, Kari

Published
2024
Full Text
View/download PDF

8. Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease

Author

Saedis Saevarsdottir, Kristbjörg Bjarnadottir, Thorsteinn Markusson, Jonas Berglund, Thorunn A. Olafsdottir, Gisli H. Halldorsson, Gudrun Rutsdottir, Kristbjorg Gunnarsdottir, Asgeir Orn Arnthorsson, Sigrun H. Lund, Lilja Stefansdottir, Julius Gudmundsson, Ari J. Johannesson, Arni Sturluson, Asmundur Oddsson, Bjarni Halldorsson, Björn R. Ludviksson, Egil Ferkingstad, Erna V. Ivarsdottir, Gardar Sveinbjornsson, Gerdur Grondal, Gisli Masson, Grimur Hjorleifsson Eldjarn, Gudmundur A. Thorisson, Katla Kristjansdottir, Kirk U. Knowlton, Kristjan H. S. Moore, Sigurjon A. Gudjonsson, Solvi Rognvaldsson, Stacey Knight, Lincoln D. Nadauld, Hilma Holm, Olafur T. Magnusson, Patrick Sulem, Daniel F. Gudbjartsson, Thorunn Rafnar, Gudmar Thorleifsson, Pall Melsted, Gudmundur L. Norddahl, Ingileif Jonsdottir, and Kari Stefansson

Subjects
Science
Abstract

Abstract Autoimmune thyroid disease (AITD) is a common autoimmune disease. In a GWAS meta-analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are associated with AITD. Of these variants, 115 are previously unreported. Multiomics analysis yields 235 candidate genes outside the MHC-region and the findings highlight the importance of genes involved in T-cell regulation. A rare 5’-UTR variant (rs781745126-T, MAF = 0.13% in Iceland) in LAG3 has the largest effect (OR = 3.42, P = 2.2 × 10−16) and generates a novel start codon for an open reading frame upstream of the canonical protein translation initiation site. rs781745126-T reduces mRNA and surface expression of the inhibitory immune checkpoint LAG-3 co-receptor on activated lymphocyte subsets and halves LAG-3 levels in plasma among heterozygotes. All three homozygous carriers of rs781745126-T have AITD, of whom one also has two other T-cell mediated diseases, that is vitiligo and type 1 diabetes. rs781745126-T associates nominally with vitiligo (OR = 5.1, P = 6.5 × 10−3) but not with type 1 diabetes. Thus, the effect of rs781745126-T is akin to drugs that inhibit LAG-3, which unleash immune responses and can have thyroid dysfunction and vitiligo as adverse events. This illustrates how a multiomics approach can reveal potential drug targets and safety concerns.

Published
2024
Full Text
View/download PDF

9. Paraconsistent and Paracomplete Zermelo-Fraenkel Set Theory

Author

Khomskii, Yurii and Oddsson, Hrafn Valtýr

Subjects
Mathematics - Logic, 03E70, 03B53, 03B60
Abstract

We present a novel treatment of set theory in a four-valued paraconsistent and paracomplete logic, i.e., a logic in which propositions can be both true and false, and neither true nor false. Our approach is a significant departure from previous research in paraconsistent set theory, which has almost exclusively been motivated by a desire to avoid Russell's paradox and fulfil naive comprehension. Instead, we prioritise setting up a system with a clear ontology of non-classical sets, which can be used to reason informally about incomplete and inconsistent phenomena, and is sufficiently similar to ZFC to enable the development of interesting mathematics. We propose an axiomatic system BZFC, obtained by analysing the ZFC-axioms and translating them to a four-valued setting in a careful manner, avoiding many of the obstacles encountered by other attempted formalizations. We introduce the anti-classicality axiom postulating the existence of non-classical sets, and prove a surprising results stating that the existence of a single non-classical set is sufficient to produce any other type of non-classical set. Our theory is naturally bi-interpretable with ZFC, and provides a philosophically satisfying view in which non-classical sets can be seen as a natural extension of classical ones, in a similar way to the non-well-founded sets of Peter Aczel. Finally, we provide an interesting application concerning Tarski semantics, showing that the classical definition of the satisfaction relation yields a logic precisely reflecting the non-classicality in the meta-theory.

Published
2022

10. Author Correction: Large-scale plasma proteomics comparisons through genetics and disease associations

Author

Eldjarn, Grimur Hjorleifsson, Ferkingstad, Egil, Lund, Sigrun H., Helgason, Hannes, Magnusson, Olafur Th., Gunnarsdottir, Kristbjorg, Olafsdottir, Thorunn A., Halldorsson, Bjarni V., Olason, Pall I., Zink, Florian, Gudjonsson, Sigurjon A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Gisli H., Magnusson, Magnus K., Saevarsdottir, Saedis, Eiriksdottir, Thjodbjorg, Masson, Gisli, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Thorleifsson, Gudmar, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari

Published
2024
Full Text
View/download PDF

12. Design and Mechanical Characterization of a Variable Stiffness ESR Foot Prosthesis

Author

Johnnidel Tabucol, Marco Leopaldi, Tommaso Maria Brugo, Magnus Oddsson, and Andrea Zucchelli

Subjects
Prosthetics, rehabilitation, variable stiffness foot prosthesis, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

In this article, MyFlex- $\epsilon $ , an ESR foot prosthesis equipped with a light and manually adjustable mechanism that allows for varying its stiffness in the sagittal plane, and a systematic approach to calculate its rotation-stiffness curves are presented. Through a design of experiment conducted numerically using a two-dimensional (2D) finite element (FE) model, calibrated experimentally, a geometric parameter whose variation alters the sagittal plane stiffness of a prosthesis originally designed with invariable stiffness, MyFlex- $\delta $ , was determined. After building the mechanism and integrating it into MyFlex- $\delta $ to obtain MyFlex- $\epsilon $ , the displacement-force curves of the latter through tests equivalent to the static tests specified in ISO 10328 were determined. Based on the experimental results, the 2D FE model of MyFlex- $\epsilon $ was built and calibrated to determine its rotation-stiffness curves in the sagittal plane. Comparing the rotation-stiffness curves obtained with the most compliant setting to the stiffest setting, stiffness variations of 119%, 122%, 138%, and 162% at plantarflexion angles of −5° and −2.5°, and dorsiflexion angles of 7.5° and 15°, respectively, were found.

Published
2024
Full Text
View/download PDF

13. Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura

Author

Bjornsdottir, Gyda, Chalmer, Mona A., Stefansdottir, Lilja, Skuladottir, Astros Th., Einarsson, Gudmundur, Andresdottir, Margret, Beyter, Doruk, Ferkingstad, Egil, Gretarsdottir, Solveig, Halldorsson, Bjarni V., Halldorsson, Gisli H., Helgadottir, Anna, Helgason, Hannes, Hjorleifsson Eldjarn, Grimur, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Jonsdottir, Ingileif, Knowlton, Kirk U., Nadauld, Lincoln D., Lund, Sigrun H., Magnusson, Olafur Th., Melsted, Pall, Moore, Kristjan H. S., Oddsson, Asmundur, Olason, Pall I., Sigurdsson, Asgeir, Stefansson, Olafur A., Saemundsdottir, Jona, Sveinbjornsson, Gardar, Tragante, Vinicius, Unnsteinsdottir, Unnur, Walters, G. Bragi, Zink, Florian, Rødevand, Linn, Andreassen, Ole A., Igland, Jannicke, Lie, Rolv T., Haavik, Jan, Banasik, Karina, Brunak, Søren, Didriksen, Maria, T. Bruun, Mie, Erikstrup, Christian, Kogelman, Lisette J. A., Nielsen, Kaspar R., Sørensen, Erik, Pedersen, Ole B., Ullum, Henrik, Masson, Gisli, Thorsteinsdottir, Unnur, Olesen, Jes, Ludvigsson, Petur, Thorarensen, Olafur, Bjornsdottir, Anna, Sigurdardottir, Gudrun R., Sveinsson, Olafur A., Ostrowski, Sisse R., Holm, Hilma, Gudbjartsson, Daniel F., Thorleifsson, Gudmar, Sulem, Patrick, Stefansson, Hreinn, Thorgeirsson, Thorgeir E., Hansen, Thomas F., and Stefansson, Kari

Published
2023
Full Text
View/download PDF

14. An atlas of genetic determinants of forearm fracture

Author

Nethander, Maria, Movérare-Skrtic, Sofia, Kämpe, Anders, Coward, Eivind, Reimann, Ene, Grahnemo, Louise, Borbély, Éva, Helyes, Zsuzsanna, Funck-Brentano, Thomas, Cohen-Solal, Martine, Tuukkanen, Juha, Koskela, Antti, Wu, Jianyao, Li, Lei, Lu, Tianyuan, Gabrielsen, Maiken E., Mägi, Reedik, Hoff, Mari, Lerner, Ulf H., Henning, Petra, Ullum, Henrik, Erikstrup, Christian, Brunak, Søren, Langhammer, Arnulf, Tuomi, Tiinamaija, Oddsson, Asmundur, Stefansson, Kari, Pettersson-Kymmer, Ulrika, Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Styrkarsdottir, Unnur, Mäkitie, Outi, Hveem, Kristian, Richards, J. Brent, and Ohlsson, Claes

Published
2023
Full Text
View/download PDF

15. Large-scale plasma proteomics comparisons through genetics and disease associations

Author

Eldjarn, Grimur Hjorleifsson, Ferkingstad, Egil, Lund, Sigrun H., Helgason, Hannes, Magnusson, Olafur Th., Gunnarsdottir, Kristbjorg, Olafsdottir, Thorunn A., Halldorsson, Bjarni V., Olason, Pall I., Zink, Florian, Gudjonsson, Sigurjon A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Gisli H., Magnusson, Magnus K., Saevarsdottir, Saedis, Eiriksdottir, Thjodbjorg, Masson, Gisli, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Thorleifsson, Gudmar, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari

Published
2023
Full Text
View/download PDF

16. Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria

Author

Kristjansson, Ragnar P., Oskarsson, Gudjon R., Skuladottir, Astros, Oddsson, Asmundur, Rognvaldsson, Solvi, Sveinbjornsson, Gardar, Lund, Sigrun H., Jensson, Brynjar O., Styrmisdottir, Edda L., Halldorsson, Gisli H., Ferkingstad, Egil, Eldjarn, Grimur Hjorleifsson, Beyter, Doruk, Kristmundsdottir, Snædis, Juliusson, Kristinn, Fridriksdottir, Run, Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Snorradottir, Margret H., Tragante, Vinicius, Stefansdottir, Lilja, Ivarsdottir, Erna V., Bjornsdottir, Gyda, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Ludviksson, Bjorn R., Onundarson, Pall T., Saevarsdottir, Saedis, Melsted, Pall, Norddahl, Gudmundur L., Bjornsdottir, Unnur S., Olafsdottir, Thorunn, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Sulem, Patrick, and Stefansson, Kari

Published
2023
Full Text
View/download PDF

17. Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality

Author

Oddsson, Asmundur, Sulem, Patrick, Sveinbjornsson, Gardar, Arnadottir, Gudny A., Steinthorsdottir, Valgerdur, Halldorsson, Gisli H., Atlason, Bjarni A., Oskarsson, Gudjon R., Helgason, Hannes, Nielsen, Henriette Svarre, Westergaard, David, Karjalainen, Juha M., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Jensson, Brynjar O., Tragante, Vinicius, Ferkingstad, Egil, Jonsson, Hakon, Gudjonsson, Sigurjon A., Beyter, Doruk, Moore, Kristjan H. S., Thordardottir, Helga B., Kristmundsdottir, Snaedis, Stefansson, Olafur A., Rantapää-Dahlqvist, Solbritt, Sonderby, Ida Elken, Didriksen, Maria, Stridh, Pernilla, Haavik, Jan, Tryggvadottir, Laufey, Frei, Oleksandr, Walters, G. Bragi, Kockum, Ingrid, Hjalgrim, Henrik, Olafsdottir, Thorunn A., Selbaek, Geir, Nyegaard, Mette, Erikstrup, Christian, Brodersen, Thorsten, Saevarsdottir, Saedis, Olsson, Tomas, Nielsen, Kaspar Rene, Haraldsson, Asgeir, Bruun, Mie Topholm, Hansen, Thomas Folkmann, Steingrimsdottir, Thora, Jacobsen, Rikke Louise, Lie, Rolv T., Djurovic, Srdjan, Alfredsson, Lars, Lopez de Lapuente Portilla, Aitzkoa, Brunak, Soren, Melsted, Pall, Halldorsson, Bjarni V., Saemundsdottir, Jona, Magnusson, Olafur Th., Padyukov, Leonid, Banasik, Karina, Rafnar, Thorunn, Askling, Johan, Klareskog, Lars, Pedersen, Ole Birger, Masson, Gisli, Havdahl, Alexandra, Nilsson, Bjorn, Andreassen, Ole A., Daly, Mark, Ostrowski, Sisse Rye, Jonsdottir, Ingileif, Stefansson, Hreinn, Holm, Hilma, Helgason, Agnar, Thorsteinsdottir, Unnur, Stefansson, Kari, and Gudbjartsson, Daniel F.

Published
2023
Full Text
View/download PDF

18. Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality

Author

Oddsson, Asmundur, Sulem, Patrick, Sveinbjornsson, Gardar, Arnadottir, Gudny A., Steinthorsdottir, Valgerdur, Halldorsson, Gisli H., Atlason, Bjarni A., Oskarsson, Gudjon R., Helgason, Hannes, Nielsen, Henriette Svarre, Westergaard, David, Karjalainen, Juha M., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Jensson, Brynjar O., Tragante, Vinicius, Ferkingstad, Egil, Jonsson, Hakon, Gudjonsson, Sigurjon A., Beyter, Doruk, Moore, Kristjan H. S., Thordardottir, Helga B., Kristmundsdottir, Snaedis, Stefansson, Olafur A., Rantapää-Dahlqvist, Solbritt, Sonderby, Ida Elken, Didriksen, Maria, Stridh, Pernilla, Haavik, Jan, Tryggvadottir, Laufey, Frei, Oleksandr, Walters, G. Bragi, Kockum, Ingrid, Hjalgrim, Henrik, Olafsdottir, Thorunn A., Selbaek, Geir, Nyegaard, Mette, Erikstrup, Christian, Brodersen, Thorsten, Saevarsdottir, Saedis, Olsson, Tomas, Nielsen, Kaspar Rene, Haraldsson, Asgeir, Bruun, Mie Topholm, Hansen, Thomas Folkmann, Steingrimsdottir, Thora, Jacobsen, Rikke Louise, Lie, Rolv T., Djurovic, Srdjan, Alfredsson, Lars, Lopez de Lapuente Portilla, Aitzkoa, Brunak, Soren, Melsted, Pall, Halldorsson, Bjarni V., Saemundsdottir, Jona, Magnusson, Olafur Th., Padyukov, Leonid, Banasik, Karina, Rafnar, Thorunn, Askling, Johan, Klareskog, Lars, Pedersen, Ole Birger, Masson, Gisli, Havdahl, Alexandra, Nilsson, Bjorn, Andreassen, Ole A., Daly, Mark, Ostrowski, Sisse Rye, Jonsdottir, Ingileif, Stefansson, Hreinn, Holm, Hilma, Helgason, Agnar, Thorsteinsdottir, Unnur, Stefansson, Kari, and Gudbjartsson, Daniel F.

Published
2023
Full Text
View/download PDF

19. A Pilot Study to Evaluate the Relationships between Supine Proprioception Assessments and Upright Functional Mobility

Author

Rachel F. Bellisle, Brian T. Peters, Lars Oddsson, Scott J. Wood, and Timothy R. Macaulay

Subjects
proprioception, postural control, bedrest, assessment, balance, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Long-duration bedrest impairs upright postural and locomotor control, prompting the need for assessment tools to predict the effects of deconditioning on post-bedrest outcome measures. We developed a tilt board mounted vertically with a horizontal air-bearing sled as a potential supine assessment tool for a future bedrest study. The purpose of this pilot study was to examine the association between supine proprioceptive assessments on the tilt board and upright functional mobility. Seventeen healthy participants completed variations of a supine tilt board task and an upright functional mobility task (FMT), which is an established obstacle avoidance course. During the supine tasks, participants lay on the air-bearing sled with axial loading toward the tilt board. Participants tilted the board to capture virtual targets on an overhead monitor during 30 s trials. The tasks included two dynamic tasks (i.e., double-leg stance matching mediolateral tilt targets over ±3° or ±9° ranges) and two static tasks (i.e., single-leg stance maintaining a central target position). The performances during the dynamic tasks were significantly correlated with the FMT time to completion. The dominant-leg static task performance showed a moderate trend with the FMT time to completion. The results indicate that supine proprioceptive assessments may be associated with upright ambulation performance, and thus, support the proposed application in bedrest studies.

Published
2024
Full Text
View/download PDF

20. The eruption in Fagradalsfjall (2021, Iceland): how the operational monitoring and the volcanic hazard assessment contributed to its safe access

Author

Barsotti, S., Parks, M. M., Pfeffer, M. A., Óladóttir, B. A., Barnie, T., Titos, M. M., Jónsdóttir, K., Pedersen, G. B. M., Hjartardóttir, Á. R., Stefansdóttir, G., Johannsson, T., Arason, Þ., Gudmundsson, M. T., Oddsson, B., Þrastarson, R. H., Ófeigsson, B. G., Vogfjörd, K., Geirsson, H., Hjörvar, T., von Löwis, S., Petersen, G. N., and Sigurðsson, E. M.

Published
2023
Full Text
View/download PDF

21. Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria

Author

Ragnar P. Kristjansson, Gudjon R. Oskarsson, Astros Skuladottir, Asmundur Oddsson, Solvi Rognvaldsson, Gardar Sveinbjornsson, Sigrun H. Lund, Brynjar O. Jensson, Edda L. Styrmisdottir, Gisli H. Halldorsson, Egil Ferkingstad, Grimur Hjorleifsson Eldjarn, Doruk Beyter, Snædis Kristmundsdottir, Kristinn Juliusson, Run Fridriksdottir, Gudny A. Arnadottir, Hildigunnur Katrinardottir, Margret H. Snorradottir, Vinicius Tragante, Lilja Stefansdottir, Erna V. Ivarsdottir, Gyda Bjornsdottir, Bjarni V. Halldorsson, Gudmar Thorleifsson, Bjorn R. Ludviksson, Pall T. Onundarson, Saedis Saevarsdottir, Pall Melsted, Gudmundur L. Norddahl, Unnur S. Bjornsdottir, Thorunn Olafsdottir, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Patrick Sulem, and Kari Stefansson

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Urticaria is a skin disorder characterized by outbreaks of raised pruritic wheals. In order to identify sequence variants associated with urticaria, we performed a meta-analysis of genome-wide association studies for urticaria with a total of 40,694 cases and 1,230,001 controls from Iceland, the UK, Finland, and Japan. We also performed transcriptome- and proteome-wide analyses in Iceland and the UK. We found nine sequence variants at nine loci associating with urticaria. The variants are at genes participating in type 2 immune responses and/or mast cell biology (CBLB, FCER1A, GCSAML, STAT6, TPSD1, ZFPM1), the innate immunity (C4), and NF-κB signaling. The most significant association was observed for the splice-donor variant rs56043070[A] (hg38: chr1:247556467) in GCSAML (MAF = 6.6%, OR = 1.24 (95%CI: 1.20–1.28), P-value = 3.6 × 10-44). We assessed the effects of the variants on transcripts, and levels of proteins relevant to urticaria pathophysiology. Our results emphasize the role of type 2 immune response and mast cell activation in the pathogenesis of urticaria. Our findings may point to an IgE-independent urticaria pathway that could help address unmet clinical need.

Published
2023
Full Text
View/download PDF

22. Volcanic plume height monitoring using calibrated web cameras at the Icelandic Meteorological Office: system overview and first application during the 2021 Fagradalsfjall eruption

Author

Talfan Barnie, Tryggvi Hjörvar, Manuel Titos, Eysteinn M. Sigurðsson, Sighvatur K. Pálsson, Bergur Bergsson, Þorgils Ingvarsson, Melissa Anne Pfeffer, Sara Barsotti, Þórður Arason, Vilhjálmur S. Þorvaldsson, Sibylle von Löwis of Menar, and Björn Oddsson

Subjects
Volcano, Eruption, Webcam, Calibration, Plume height, Environmental protection, TD169-171.8, Disasters and engineering, TA495
Abstract

Abstract The Icelandic Meteorological Office maintains a national network of webcams designed and built in house for environmental monitoring. During the 2021 Fagradalsfjall eruption these cameras, along with a temporary near-field network of commercial cameras installed by the Department of Civil Protection and Emergency Management, were used to estimate the height of the $$SO_2$$ S O 2 plume and lava fountain. Here we present the webcam designs, the techniques used to calibrate them, and the messaging system and web interface that allow near real time measurements to be made from the images. With this system we were able to make estimates of heights with an accuracy on the order of tens to a few hundreds of meters with a lag typically of five to ten minutes at up to ten minute intervals when weather conditions were favorable. The plume heights were then used to constrain the performance of the $$SO_2$$ S O 2 dispersion model used for air quality forecasts while fountain heights were used to delineate danger zones where visitors at the eruption site were in danger of being hit by ballistic clasts.

Published
2023
Full Text
View/download PDF

23. Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality

Author

Asmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Henriette Svarre Nielsen, David Westergaard, Juha M. Karjalainen, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O. Jensson, Vinicius Tragante, Egil Ferkingstad, Hakon Jonsson, Sigurjon A. Gudjonsson, Doruk Beyter, Kristjan H. S. Moore, Helga B. Thordardottir, Snaedis Kristmundsdottir, Olafur A. Stefansson, Solbritt Rantapää-Dahlqvist, Ida Elken Sonderby, Maria Didriksen, Pernilla Stridh, Jan Haavik, Laufey Tryggvadottir, Oleksandr Frei, G. Bragi Walters, Ingrid Kockum, Henrik Hjalgrim, Thorunn A. Olafsdottir, Geir Selbaek, Mette Nyegaard, Christian Erikstrup, Thorsten Brodersen, Saedis Saevarsdottir, Tomas Olsson, Kaspar Rene Nielsen, Asgeir Haraldsson, Mie Topholm Bruun, Thomas Folkmann Hansen, DBDS Genomic Consortium, Thora Steingrimsdottir, Rikke Louise Jacobsen, Rolv T. Lie, Srdjan Djurovic, Lars Alfredsson, Aitzkoa Lopez de Lapuente Portilla, Soren Brunak, Pall Melsted, Bjarni V. Halldorsson, Jona Saemundsdottir, Olafur Th. Magnusson, Leonid Padyukov, Karina Banasik, Thorunn Rafnar, Johan Askling, Lars Klareskog, Ole Birger Pedersen, Gisli Masson, Alexandra Havdahl, Bjorn Nilsson, Ole A. Andreassen, Mark Daly, Sisse Rye Ostrowski, Ingileif Jonsdottir, Hreinn Stefansson, Hilma Holm, Agnar Helgason, Unnur Thorsteinsdottir, Kari Stefansson, and Daniel F. Gudbjartsson

Subjects
Science
Abstract

Abstract Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygosity among 1.52 million individuals from six European populations. In this study, we identified 25 genes harboring protein-altering sequence variants with a strong deficit of homozygosity (10% or less of predicted homozygotes). Sequence variants in 12 of the genes cause Mendelian disease under a recessive mode of inheritance, two under a dominant mode, but variants in the remaining 11 have not been reported to cause disease. Sequence variants with a strong deficit of homozygosity are over-represented among genes essential for growth of human cell lines and genes orthologous to mouse genes known to affect viability. The function of these genes gives insight into the genetics of intrauterine lethality. We also identified 1077 genes with homozygous predicted loss-of-function genotypes not previously described, bringing the total set of genes completely knocked out in humans to 4785.

Published
2023
Full Text
View/download PDF

24. User Engagement, Acceptability, and Clinical Markers in a Digital Health Program for Nonalcoholic Fatty Liver Disease: Prospective, Single-Arm Feasibility Study

Author

Sigridur Björnsdottir, Hildigunnur Ulfsdottir, Elias Freyr Gudmundsson, Kolbrun Sveinsdottir, Ari Pall Isberg, Bartosz Dobies, Gudlaug Erla Akerlie Magnusdottir, Thrudur Gunnarsdottir, Tekla Karlsdottir, Gudlaug Bjornsdottir, Sigurdur Sigurdsson, Saemundur Oddsson, and Vilmundur Gudnason

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundNonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world. Common comorbidities are central obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome. Cardiovascular disease is the most common cause of death among people with NAFLD, and lifestyle changes can improve health outcomes. ObjectiveThis study aims to explore the acceptability of a digital health program in terms of engagement, retention, and user satisfaction in addition to exploring changes in clinical outcomes, such as weight, cardiometabolic risk factors, and health-related quality of life. MethodsWe conducted a prospective, open-label, single-arm, 12-week study including 38 individuals with either a BMI >30, metabolic syndrome, or type 2 diabetes mellitus and NAFLD screened by FibroScan. An NAFLD-specific digital health program focused on disease education, lowering carbohydrates in the diet, food logging, increasing activity level, reducing stress, and healthy lifestyle coaching was offered to participants. The coach provided weekly feedback on food logs and other in-app activities and opportunities for participants to ask questions. The coaching was active throughout the 12-week intervention period. The primary outcome was feasibility and acceptability of the 12-week program, assessed through patient engagement, retention, and satisfaction with the program. Secondary outcomes included changes in weight, liver fat, body composition, and other cardiometabolic clinical parameters at baseline and 12 weeks. ResultsIn total, 38 individuals were included in the study (median age 59.5, IQR 46.3-68.8 years; n=23, 61% female). Overall, 34 (89%) participants completed the program and 29 (76%) were active during the 12-week program period. The median satisfaction score was 6.3 (IQR 5.8-6.7) of 7. Mean weight loss was 3.5 (SD 3.7) kg (P

Published
2024
Full Text
View/download PDF

25. Geology and geodiversity of the Folafótur peninsula (Westfjords, Iceland)

Author

Alessandro Ellero, Björn Oddsson, and Giuseppe Ottria

Subjects
Geological mapping, geomorphology, geodiversity, Westfjords, Iceland, Maps, G3180-9980
Abstract

ABSTRACTGeological and geomorphological field surveys and mapping have been carried out in the Folafótur peninsula (Westfjords, Iceland), a remote territory characterized by spectacular landscapes resulting from the interaction of volcanic, tectonic, and glacial processes. The Geological and Geomorphological Map of the Folafótur Peninsula (1:10,000 scale) is the first detailed map showing the relationships between geology and landscapes in the Westfjords of Iceland. The map also highlights the main geodiversity and cultural sites, which together make up the overall value of the geoheritage of the study area, illustrating Earth’s geodynamics and geomorphological processes related to climate changes and their connections with human history. Our research contributes to the understanding of the geodiversity of the Folafótur peninsula, providing for the first time a description of geological and geomorphological characteristics of this area, crucial for the assessment of its geoheritage.

Published
2023
Full Text
View/download PDF

26. Assessing the Relationships Between Sensorimotor Biomarkers and Post-Landing Functional Task Performance

Author

S J Wood, Y E De Dios, T R Macaulay, B T Peters, N E Beltran, V Koppelmans, T K Clark, R D Seidler, L Oddsson, C A Theriot, and J J Bloomberg

Subjects
Aerospace Medicine
Abstract

Spaceflight drives adaptive changes in healthy individuals appropriate for sensorimotor function in a microgravity environment. These changes are maladaptive for return to earth's gravity. The inter-individual variability of sensorimotor decrements is striking, although poorly understood. The goal of this study is to identify a set of behavioral, neuroimaging and genetic measures that can be used to predict early post-flight performance on a set of sensorimotor tasks. Astronauts are recruited who previously participated in sensorimotor field tests and/or posturography soon after long-duration spaceflight. Behavioral tests include assessments of sensory dependency and adaptability. Visual dependency involves treadmill walking while viewing a moving virtual visual scene. Vestibular perceptual thresholds are measured while seated during lateral translations. Proprioception dependency is measured during one-legged stance on a horizontal air-bearing surface. Ground assessment of adaptability is performed(1) during treadmill walking with a virtual linear hallway and a moving walking surface, and (2) during multiple trials of navigating an obstacle course while wearing reversing prisms(adaptive Functional Mobility Test, aFMT). The neuroimaging tests will characterize individual differences in regional brain volumes (using Structural MRI) and white matter microstructure(using Diffusion Tensor Imaging) to serve as potential predictors of adaptive capacity. The genetic tests will utilize saliva samples to examine variations in four genes chosen because of their ability to differentiate sensorimotor adaptation ability in a normative population, including Catechol-O-methyltransferase (COMT), Dopamine Receptor D2 (DRD2), Brain-derived neurotrophic factor (BDNF) and the α2-adrenergic receptor. Twenty-seven ISS crewmembers have been tested to date, including 6 from this past year. This cohort includes 10first-time fliers, 6F, and mission durations lasting 178.6 ± 30.5 days, mean ± std. We are utilizing a combination of three post-flight functional task outcomes: tandem walk, recovery from fall and dynamic posturography. There is considerable variability among the post-flight performance outcomes for the 27participants to date. Based on a partial sample using an ordinal scale survey, 70% indicated their ability to perform functional tasks were more impacted postflight relative to inflight with 50% indicating they needed to restrict movements for a longer period postflight relative to inflight. While there is a strong association within tests obtained at different R+0 timepoints, by R+24 hr performance on one post-flight test does not necessarily correlate with performance on other post-flight tests. There are apparent relationships between individual measures and specific post-flight outcome measures, e.g., the cumulative time to complete the aFMT is significantly correlated to pre-to-post-flight changes in tandem walk (rho= 0.64, p = 0.001). Preliminary statistical analysis indicates combining biomarkers will increase predictive power and this will be explored with future analyses. Our preliminary findings underscore the importance of a comprehensive post-flight test battery including different types of tasks with varying sensory feedback. We expect that understanding the relationships between these sensorimotor biomarkers and post-flight functional task performance will improve both our understanding of the individual variability and our strategy to optimize sensorimotor countermeasures

Published
2024

29. Improving outpatient care for heart failure through digital innovation: a feasibility study

Author

David O. Arnar, Saemundur J. Oddsson, Thrudur Gunnarsdottir, Gudbjorg Jona Gudlaugsdottir, Elias Freyr Gudmundsson, Audur Ketilsdóttir, Hulda Halldorsdottir, Thordis Jona Hrafnkelsdottir, Hallur Hallsson, Maria L. Amundadottir, and Tryggvi Thorgeirsson

Subjects
Clinical outcome, Digital solution, Feasibility study, Heart failure, Lifestyle-change, Remote monitoring, Medicine (General), R5-920
Abstract

Abstract Background Heart failure (HF) affects over 26 million people worldwide. Multidisciplinary management strategies that include symptom monitoring and patient self-care support reduce HF hospitalization and mortality rates. Ideally, HF follow-up and self-care support includes lifestyle-change recommendations and remote monitoring of weight and HF symptoms. Providing these via a digital solution may be ideal for improving HF disease outcomes and reducing the burden on providers and healthcare systems. This study’s main objective was to assess the feasibility of a digital solution including remote monitoring, lifestyle-change, and self-care support for HF outpatients in Iceland. Methods Twenty HF patients (mean age 57.5 years, 80% males) participated in an 8-week study. They were provided with a digital solution (SK-141), including lifestyle-change and disease self-care support, a remote symptom monitoring system, and a secure messaging platform between healthcare providers and patients. This feasibility study aimed to assess patient acceptability of this new intervention, retention rate, and to evaluate trends in clinical outcomes. To assess the acceptability of SK-141, participants completed a questionnaire about their experience after the 8-week study. Participants performed daily assigned activities (missions), including self-reporting symptoms. Clinical outcomes were assessed with the Hospital Anxiety and Depression Scale and the Kansas City Cardiomyopathy Questionnaire at the study's beginning and end with an online survey. Results Of the 24 patients invited, 20 were elected to participate. The retention rate of participants throughout the 8-week period was high (80%). At the end of the 8 weeks, thirteen participants completed a questionnaire about their experience and acceptability of the SK-141. They rated their experience positively including on questions whether they would recommend the solution to others (6.8 on a scale of 1–7), whether the solution had improved their life and well-being (5.7 on a scale of 1–7), and whether it was user friendly (5.5 on a scale of 1–7). Many of the clinical parameters studied exhibited a promising trend towards improvement over the 8-week period. Conclusion The digital solution, SK-141, was very acceptable to patients and also showed promising clinical results in this small feasibility study. These results encourage us to conduct a longer, more extensive, adequately powered, randomized-controlled study to assess whether this digital solution can improve the quality of life and clinical outcomes among HF patients.

Published
2022
Full Text
View/download PDF

30. Screening for Rare Coding Variants That Associate With the QTc Interval in Iceland

Author

Gardar Sveinbjornsson, Bara D. Benediktsdottir, Gunnlaugur Sigfusson, Kristjan Norland, Olafur B. Davidsson, Rosa B. Thorolfsdottir, Vinicius Tragante, Gudny A. Arnadottir, Brynjar O. Jensson, Hildigunnur Katrinardottir, Run Fridriksdottir, Hallbera Gudmundsdottir, Hildur M. Aegisdottir, Brynjar Fridriksson, Gudmundur Thorgeirsson, Vidar Magnusson, Asmundur Oddsson, Patrick Sulem, Daniel F. Gudbjartsson, Hilma Holm, David O. Arnar, and Kari Stefansson

Subjects
genetic epidemiology, genetics, long‐QT syndrome, precision medicine, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Long‐QT syndrome (LQTS) is a cardiac repolarization abnormality that can lead to sudden cardiac death. The most common causes are rare coding variants in the genes KCNQ1, KCNH2, and SCN5A. The data on LQTS epidemiology are limited, and information on expressivity and penetrance of pathogenic variants is sparse. Methods and Results We screened for rare coding variants associated with the corrected QT (QTc) interval in Iceland. We explored the frequency of the identified variants, their penetrance, and their association with severe events. Twelve variants were associated with the QTc interval. Five in KCNQ1, 3 in KCNH2, 2 in cardiomyopathy genes MYBPC3 and PKP2, and 2 in genes where coding variants have not been associated with the QTc interval, ISOC1 and MYOM2. The combined carrier frequency of the 8 variants in the previously known LQTS genes was 530 per 100 000 individuals (1:190). p.Tyr315Cys and p.Leu273Phe in KCNQ1 were associated with having a mean QTc interval longer than 500 ms (P=4.2×10−7; odds ratio [OR], 38.6; P=8.4×10−10, OR, 26.5; respectively), and p.Leu273Phe was associated with sudden cardiac death (P=0.0034; OR, 2.99). p.Val215Met in KCNQ1 was carried by 1 in 280 Icelanders, had a smaller effect on the QTc interval (P=1.8×10−44; effect, 22.8 ms), and did not associate with severe clinical events. Conclusions The carrier frequency of associating variants in LQTS genes was higher than previous estimates of the prevalence of LQTS. The variants have variable effects on the QTc interval, and carriers of p.Tyr315Cys and p.Leu273Phe have a more severe disease than carriers of p.Val215Met. These data could lead to improved identification, risk stratification, and a more precise clinical approach to those with QTc prolongation.

Published
2023
Full Text
View/download PDF

31. Engagement, Retention, and Acceptability in a Digital Health Program for Atopic Dermatitis: Prospective Interventional Study

Author

Sigrídur Lára Gudmundsdóttir, Tommaso Ballarini, María L Ámundadóttir, Judit Mészáros, Jenna Huld Eysteinsdottir, Ragna H Thorleifsdottir, Sigrídur K Hrafnkelsdóttir, Halla Helgadottir, Saemundur Oddsson, and Jonathan I Silverberg

Subjects
Medicine
Abstract

BackgroundPatients with atopic dermatitis can experience chronic eczema with pruritus, skin pain, sleep problems, anxiety, and other problems that reduce their quality of life (QoL). Current treatments aim to improve these symptoms and reduce inflammation, but poor treatment adherence and disease understanding are key concerns in the long-term management of atopic dermatitis. Digital therapeutics can help with these and support patients toward a healthier lifestyle to improve their overall QoL. ObjectiveThe aim of the study is to test the feasibility of a digital health program tailored for atopic dermatitis through program engagement, retention, and acceptability. MethodsAdults with atopic dermatitis were recruited in Iceland for a 6-week digital health program delivered through a smartphone app. Key components of the digital program were disease and trigger education; medication reminders; patient-reported outcomes (PROs) on energy levels, stress levels, and quality of sleep (referred to as QoL PROs); atopic dermatitis symptom PROs; guided meditation; and healthy lifestyle coaching. The primary outcome was program feasibility, as assessed by in-app retention and engagement. User satisfaction was assessed by the mHealth (ie, mobile health) App Usability Questionnaire (MAUQ). ResultsA total of 21 patients were recruited (17 female, mean age 31 years), 20 (95%) completed the program. On average, users were active in the app 6.5 days per week and completed 8.2 missions per day. The education content, medication reminders, and PROs had high user engagement and retention; all users who were exposed to the QoL PROs (n=17) interacted with these, and 20/21 (95%) users were continuously engaged with the education missions, medication missions, and symptom PROs. Continued engagement with the step counter and mind missions among exposed users was lower (17/21 and 13/20 participants, respectively). Medication reminder and education task completion remained high over time (at least 18/20, 90%), but weekly interactions declined. All assigned users completed atopic dermatitis symptom PROs on weeks 1-5 and only one did not do so on week 6; the reported number and total severity of atopic dermatitis symptoms reduced during the program. Regarding the QoL PROs, 16/17 (94%) and 14/17 (82%) users interacted with these at least 3 times in the first and last week of the program, respectively, and all reported improvements over time. User satisfaction was high with a total score of 6.2/7. ConclusionsWe found high overall engagement and retention in a targeted digital health program among patients with atopic dermatitis, as well as high compliance with missions relating to medication reminders, patient education, and PROs. Symptom number and severity were reduced, and QoL PROs improved over time. We conclude that a digital health program is feasible and may provide added benefits for patients with atopic dermatitis, including the tracking and improvement of atopic dermatitis symptoms.

Published
2023
Full Text
View/download PDF

33. The sequences of 150,119 genomes in the UK Biobank

Author

Halldorsson, Bjarni V., Eggertsson, Hannes P., Moore, Kristjan H. S., Hauswedell, Hannes, Eiriksson, Ogmundur, Ulfarsson, Magnus O., Palsson, Gunnar, Hardarson, Marteinn T., Oddsson, Asmundur, Jensson, Brynjar O., Kristmundsdottir, Snaedis, Sigurpalsdottir, Brynja D., Stefansson, Olafur A., Beyter, Doruk, Holley, Guillaume, Tragante, Vinicius, Gylfason, Arnaldur, Olason, Pall I., Zink, Florian, Asgeirsdottir, Margret, Sverrisson, Sverrir T., Sigurdsson, Brynjar, Gudjonsson, Sigurjon A., Sigurdsson, Gunnar T., Halldorsson, Gisli H., Sveinbjornsson, Gardar, Norland, Kristjan, Styrkarsdottir, Unnur, Magnusdottir, Droplaug N., Snorradottir, Steinunn, Kristinsson, Kari, Sobech, Emilia, Jonsson, Helgi, Geirsson, Arni J., Olafsson, Isleifur, Jonsson, Palmi, Pedersen, Ole Birger, Erikstrup, Christian, Brunak, Søren, Ostrowski, Sisse Rye, Thorleifsson, Gudmar, Jonsson, Frosti, Melsted, Pall, Jonsdottir, Ingileif, Rafnar, Thorunn, Holm, Hilma, Stefansson, Hreinn, Saemundsdottir, Jona, Gudbjartsson, Daniel F., Magnusson, Olafur T., Masson, Gisli, Thorsteinsdottir, Unnur, Helgason, Agnar, Jonsson, Hakon, Sulem, Patrick, and Stefansson, Kari

Published
2022
Full Text
View/download PDF

34. CNES-ESA satellite contribution to the operational monitoring of volcanic activity: The 2021 Icelandic eruption of Mt. Fagradalsfjall

Author

Mathieu Gouhier, Virginie Pinel, Joaquín M. C. Belart, Marcello De Michele, Catherine Proy, Claire Tinel, Etienne Berthier, Yannick Guéhenneux, Magnus Tumi Gudmundsson, Birgir V. Óskarsson, Shan Gremion, Daniel Raucoules, Sébastien Valade, Francesco Massimetti, and Bjorn Oddsson

Subjects
Volcanology, Remote sensing, Pléiades images, Infrared monitoring, Lava, Environmental protection, TD169-171.8, Disasters and engineering, TA495
Abstract

Abstract Within the framework of the CIEST2 (Cellule d'Intervention d'Expertise Scientifique et Technique new generation) and thanks to the support of CNES, the French space agency, the first phase of the Fagradalsfjall eruption was exceptionally well covered by high resolution optical satellite data, through daily acquisitions of Pléiades images in stereo mode. In this study, we show how Pléiades data provided real-time information useful for the operational monitoring of the ongoing eruption. An estimation of the volume of lava emitted as well as the corresponding effusion rate could be derived and delivered to the civil protection less than 6 h after the data acquisition. This information is complementary to and consistent with estimates obtained through the HOTVOLC service using SEVIRI (Spinning Enhanced Visible and Infrared Imager) sensor on-board Meteosat Second Generation (MGS) geostationary satellites, operated by the European Space Agency (ESA), characterized by a lower spatial resolution and a higher temporal one. In addition to the information provided on the lava emission, Pléiades data also helped characterize the intensity of the eruption by providing insight into the elevation and the velocity of the volcanic plume. The survey of this effusive eruption, well anticipated by a series of precursors, is a proof of concept of the efficiency of optical/thermal satellite data for volcanic crisis real-time monitoring.

Published
2022
Full Text
View/download PDF

35. Genetic architecture of band neutrophil fraction in Iceland

Author

Gudjon R. Oskarsson, Magnus K. Magnusson, Asmundur Oddsson, Brynjar O. Jensson, Run Fridriksdottir, Gudny A. Arnadottir, Hildigunnur Katrinardottir, Solvi Rognvaldsson, Gisli H. Halldorsson, Gardar Sveinbjornsson, Erna V. Ivarsdottir, Lilja Stefansdottir, Egil Ferkingstad, Kristjan Norland, Vinicius Tragante, Jona Saemundsdottir, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Svanhvit Sigurjonsdottir, Karen O. Petursdottir, Olafur B. Davidsson, Thorunn Rafnar, Hilma Holm, Isleifur Olafsson, Pall T. Onundarson, Brynjar Vidarsson, Olof Sigurdardottir, Gisli Masson, Daniel F. Gudbjartsson, Ingileif Jonsdottir, Gudmundur L. Norddahl, Unnur Thorsteinsdottir, Patrick Sulem, and Kari Stefansson

Subjects
Biology (General), QH301-705.5
Abstract

A GWAS in Iceland reveals that variants in inner nuclear membrane proteins are associated with nuclear morphology of granulocytes and band neutrophil fraction.

Published
2022
Full Text
View/download PDF

37. A New Digital Health Program for Patients With Inflammatory Bowel Disease: Preliminary Program Evaluation

Author

Saemundur Jon Oddsson, Thrudur Gunnarsdottir, Lilja Gudrun Johannsdottir, Maria Lovisa Amundadottir, Arna Frimannsdottir, Pauliina Molander, Anna Karoliina Ylanne, Anna Sigridur Islind, Maria Oskarsdottir, and Tryggvi Thorgeirsson

Subjects
Medicine
Abstract

BackgroundInflammatory bowel disease (IBD) causes chronic inflammation of the gastrointestinal tract. IBD is characterized by an unpredictable disease course that varies greatly between individuals and alternates between the periods of relapse and remission. A low energy level (fatigue) is a common symptom, whereas stress and reduced sleep quality may be the triggering factors. Therapeutic guidelines call for effective disease assessment, early intervention, and personalized care using a treat-to-target approach, which may be difficult to achieve through typical time- and resource-constrained standard care. Providing patients with a digital health program that incorporates helpful self-management features and patient support to complement standard care may be optimal for improving the disease course. ObjectiveThis study aimed to perform a preliminary program evaluation, analyzing engagement and preliminary effectiveness and the effect on participants’ energy levels (fatigue), stress, and sleep quality, of a newly developed 16-week digital health program (SK-311 and SK-321) for patients with IBD. MethodsAdults with IBD were recruited to participate in a real-world, live, digital health program via Finnish IBD patient association websites and social media. No inclusion or exclusion criteria were applied for this study. Baseline characteristics were entered by the participants upon sign-up. Platform engagement was measured by tracking the participants’ event logs. The outcome measures of stress, energy levels (fatigue), and quality of sleep were reported by participants through the platform. ResultsOf the 444 adults who registered for the digital health program, 205 (46.2%) were included in the intention-to-treat sample. The intention-to-treat participants logged events on average 41 times per week (5.9 times per day) during the weeks in which they were active on the digital platform. More women than men participated in the intervention (126/205, 88.7%). The mean age of the participants was 40.3 (SD 11.5) years, and their mean BMI was 27.9 (SD 6.0) kg/m2. In total, 80 people provided the required outcome measures during weeks 12 to 16 (completers). Treatment completion was strongly predicted by the number of active days in week 1. Analysis of the completers (80/205, 39%) showed significant improvements for stress (t79=4.57; P

Published
2023
Full Text
View/download PDF

38. Novel methods to characterise spatial distribution and enantiomeric composition of usnic acids in four Icelandic lichens

Author

Xu, Maonian, Oppong-Danquah, Ernest, Wang, Xiaoyu, Oddsson, Sebastian, Abdelrahman, Asmaa, Pedersen, Simon Vilms, Szomek, Maria, Gylfason, Aron Elvar, Snorradottir, Bergthora Sigridur, Christensen, Eva Arnspang, Tasdemir, Deniz, Jameson, Cynthia J., Murad, Sohail, Andresson, Olafur Sigmar, Magnusson, Kristinn Petur, de Boer, Hugo J., Thorsteinsdottir, Margret, Omarsdottir, Sesselja, Heidmarsson, Starri, and Olafsdottir, Elin Soffia

Published
2022
Full Text
View/download PDF

39. Genetic architecture of band neutrophil fraction in Iceland

Author

Oskarsson, Gudjon R., Magnusson, Magnus K., Oddsson, Asmundur, Jensson, Brynjar O., Fridriksdottir, Run, Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Rognvaldsson, Solvi, Halldorsson, Gisli H., Sveinbjornsson, Gardar, Ivarsdottir, Erna V., Stefansdottir, Lilja, Ferkingstad, Egil, Norland, Kristjan, Tragante, Vinicius, Saemundsdottir, Jona, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Sigurjonsdottir, Svanhvit, Petursdottir, Karen O., Davidsson, Olafur B., Rafnar, Thorunn, Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T., Vidarsson, Brynjar, Sigurdardottir, Olof, Masson, Gisli, Gudbjartsson, Daniel F., Jonsdottir, Ingileif, Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari

Published
2022
Full Text
View/download PDF

40. A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

Author

Skuladottir, Astros Th., Bjornsdottir, Gyda, Ferkingstad, Egil, Einarsson, Gudmundur, Stefansdottir, Lilja, Nawaz, Muhammad Sulaman, Oddsson, Asmundur, Olafsdottir, Thorunn A., Saevarsdottir, Saedis, Walters, G. Bragi, Magnusson, Sigurdur H., Bjornsdottir, Anna, Sveinsson, Olafur A., Vikingsson, Arnor, Hansen, Thomas Folkmann, Jacobsen, Rikke Louise, Erikstrup, Christian, Schwinn, Michael, Brunak, Søren, Banasik, Karina, Ostrowski, Sisse Rye, Troelsen, Anders, Henkel, Cecilie, Pedersen, Ole Birger, Jonsdottir, Ingileif, Gudbjartsson, Daniel F., Sulem, Patrick, Thorgeirsson, Thorgeir E., Stefansson, Hreinn, and Stefansson, Kari

Published
2022
Full Text
View/download PDF

43. Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene

Author

Arnadottir, Gudny A., Oddsson, Asmundur, Jensson, Brynjar O., Gisladottir, Svanborg, Simon, Mariella T., Arnthorsson, Asgeir O., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Ivarsdottir, Erna V., Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Barrick, Rebekah, Saemundsdottir, Jona, le Roux, Louise, Oskarsson, Gudjon R., Asmundsson, Jurate, Steffensen, Thora, Gudmundsson, Kjartan R., Ludvigsson, Petur, Jonsson, Jon J., Masson, Gisli, Jonsdottir, Ingileif, Holm, Hilma, Jonasson, Jon G., Magnusson, Olafur Th., Thorarensen, Olafur, Abdenur, Jose, Norddahl, Gudmundur L., Gudbjartsson, Daniel F., Bjornsson, Hans T., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari

Published
2022
Full Text
View/download PDF

44. Author Correction: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Author

Bjornsdottir, Gyda, Stefansdottir, Lilja, Thorleifsson, Gudmar, Sulem, Patrick, Norland, Kristjan, Ferkingstad, Egil, Oddsson, Asmundur, Zink, Florian, Lund, Sigrun H., Nawaz, Muhammad S., Bragi Walters, G., Skuladottir, Astros Th., Gudjonsson, Sigurjon A., Einarsson, Gudmundur, Halldorsson, Gisli H., Bjarnadottir, Valgerdur, Sveinbjornsson, Gardar, Helgadottir, Anna, Styrkarsdottir, Unnur, Gudmundsson, Larus J., Pedersen, Ole B., Hansen, Thomas Folkmann, Werge, Thomas, Banasik, Karina, Troelsen, Anders, Skou, Soren T., Thørner, Lise Wegner, Erikstrup, Christian, Nielsen, Kaspar Rene, Mikkelsen, Susan, Jonsdottir, Ingileif, Bjornsson, Aron, Olafsson, Ingvar H., Ulfarsson, Elfar, Blondal, Josep, Vikingsson, Arnor, Brunak, Soren, Ostrowski, Sisse R., Ullum, Henrik, Thorsteinsdottir, Unnur, Stefansson, Hreinn, Gudbjartsson, Daniel F., Thorgeirsson, Thorgeir E., and Stefansson, Kari

Published
2022
Full Text
View/download PDF

45. Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Author

Bjornsdottir, Gyda, Stefansdottir, Lilja, Thorleifsson, Gudmar, Sulem, Patrick, Norland, Kristjan, Ferkingstad, Egil, Oddsson, Asmundur, Zink, Florian, Lund, Sigrun H., Nawaz, Muhammad S., Bragi Walters, G., Skuladottir, Astros Th., Gudjonsson, Sigurjon A., Einarsson, Gudmundur, Halldorsson, Gisli H., Bjarnadottir, Valgerdur, Sveinbjornsson, Gardar, Helgadottir, Anna, Styrkarsdottir, Unnur, Gudmundsson, Larus J., Pedersen, Ole B., Hansen, Thomas Folkmann, Werge, Thomas, Banasik, Karina, Troelsen, Anders, Skou, Soren T., Thørner, Lise Wegner, Erikstrup, Christian, Nielsen, Kaspar Rene, Mikkelsen, Susan, Jonsdottir, Ingileif, Bjornsson, Aron, Olafsson, Ingvar H., Ulfarsson, Elfar, Blondal, Josep, Vikingsson, Arnor, Brunak, Soren, Ostrowski, Sisse R., Ullum, Henrik, Thorsteinsdottir, Unnur, Stefansson, Hreinn, Gudbjartsson, Daniel F., Thorgeirsson, Thorgeir E., and Stefansson, Kari

Published
2022
Full Text
View/download PDF

46. A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

Author

Astros Th. Skuladottir, Gyda Bjornsdottir, Egil Ferkingstad, Gudmundur Einarsson, Lilja Stefansdottir, Muhammad Sulaman Nawaz, Asmundur Oddsson, Thorunn A. Olafsdottir, Saedis Saevarsdottir, G. Bragi Walters, Sigurdur H. Magnusson, Anna Bjornsdottir, Olafur A. Sveinsson, Arnor Vikingsson, Thomas Folkmann Hansen, Rikke Louise Jacobsen, Christian Erikstrup, Michael Schwinn, Søren Brunak, Karina Banasik, Sisse Rye Ostrowski, Anders Troelsen, Cecilie Henkel, Ole Birger Pedersen, DBDS Genetic Consortium, Ingileif Jonsdottir, Daniel F. Gudbjartsson, Patrick Sulem, Thorgeir E. Thorgeirsson, Hreinn Stefansson, and Kari Stefansson

Subjects
Science
Abstract

The underlying genetics of carpal tunnel syndrome is not well understood. Here, the authors perform a GWAS meta-analysis for carpal tunnel syndrome finding variants at 50 loci with connections to the extracellular matrix discovered through various functional analyses.

Published
2022
Full Text
View/download PDF

47. Genome-Wide Association Study of Accessory Atrioventricular Pathways.

Author

Aegisdottir, Hildur M., Andreasen, Laura, Thorolfsdottir, Rosa B., Sveinbjornsson, Gardar, Jonsdottir, Andrea B., Stefansdottir, Lilja, Thorleifsson, Gudmar, Sigurdsson, Asgeir, Halldorsson, Gisli H., Barc, Julien, Simonet, Floriane, Tragante, Vinicius, Oddsson, Asmundur, Ferkingstad, Egil, Svendsen, Jesper Hastrup, Ghouse, Jonas, Ahlberg, Gustav, Paludan-Müller, Christian, Hadji-Turdeghal, Katra, and Bustamante, Mariana

Published
2024
Full Text
View/download PDF

48. Brief communication: Small-scale geohazards cause significant and highly variable impacts on emotions.

Author

Ilyinskaya, Evgenia, Snæbjarnarson, Vésteinn, Carlsen, Hanne Krage, and Oddsson, Björn

Subjects
NATURAL language processing, VOLCANIC eruptions, MENTAL health, EMOTIONS, POPULATION health
Abstract

The impact of geohazards on the mental health of local populations is well recognised but understudied. We used natural language processing (NLP) of Twitter (now known as X) posts (n=10341) to analyse the sentiments expressed in relation to a pre-eruptive seismic unrest and a subsequent volcanic eruption in Iceland in 2019–2021. We show that although these geohazards were of a small size and caused negligible material damage, they were associated with a measurable change in expressed emotions in the local population. The seismic unrest was associated with predominantly negative sentiments (positive-to-negative sentiment ratio of 1:1.3), but the eruption was associated with predominantly positive sentiments (positive-to-negative sentiment ratio of 1.4:1). We demonstrate a cost-effective tool for gauging public discourse that could be used in risk management. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene

Author

Gudny A. Arnadottir, Asmundur Oddsson, Brynjar O. Jensson, Svanborg Gisladottir, Mariella T. Simon, Asgeir O. Arnthorsson, Hildigunnur Katrinardottir, Run Fridriksdottir, Erna V. Ivarsdottir, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Rebekah Barrick, Jona Saemundsdottir, Louise le Roux, Gudjon R. Oskarsson, Jurate Asmundsson, Thora Steffensen, Kjartan R. Gudmundsson, Petur Ludvigsson, Jon J. Jonsson, Gisli Masson, Ingileif Jonsdottir, Hilma Holm, Jon G. Jonasson, Olafur Th. Magnusson, Olafur Thorarensen, Jose Abdenur, Gudmundur L. Norddahl, Daniel F. Gudbjartsson, Hans T. Bjornsson, Unnur Thorsteinsdottir, Patrick Sulem, and Kari Stefansson

Subjects
Science
Abstract

While the consequences of homozygous loss of function variants have been studied, the effect of missense variants is less understood. Here, the authors identify pathogenic genotypes through an observed deficit of homozygous carriers of missense variants in a population, elucidating previously unexplained recessive disease and miscarriage.

Published
2022
Full Text
View/download PDF

50. Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Author

Gyda Bjornsdottir, Lilja Stefansdottir, Gudmar Thorleifsson, Patrick Sulem, Kristjan Norland, Egil Ferkingstad, Asmundur Oddsson, Florian Zink, Sigrun H. Lund, Muhammad S. Nawaz, G. Bragi Walters, Astros Th. Skuladottir, Sigurjon A. Gudjonsson, Gudmundur Einarsson, Gisli H. Halldorsson, Valgerdur Bjarnadottir, Gardar Sveinbjornsson, Anna Helgadottir, Unnur Styrkarsdottir, Larus J. Gudmundsson, Ole B. Pedersen, Thomas Folkmann Hansen, Thomas Werge, Karina Banasik, Anders Troelsen, Soren T. Skou, Lise Wegner Thørner, Christian Erikstrup, Kaspar Rene Nielsen, Susan Mikkelsen, DBDS Genetic Consortium, GO Consortium, Ingileif Jonsdottir, Aron Bjornsson, Ingvar H. Olafsson, Elfar Ulfarsson, Josep Blondal, Arnor Vikingsson, Soren Brunak, Sisse R. Ostrowski, Henrik Ullum, Unnur Thorsteinsdottir, Hreinn Stefansson, Daniel F. Gudbjartsson, Thorgeir E. Thorgeirsson, and Kari Stefansson

Subjects
Science
Abstract

Little is known about the biology of back pain, a leading cause of disability. Here the authors report 30 new back pain loci, implicating genes involved in cartilage/bone biology, as well as neurological and inflammatory processes.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results