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Your search keyword '"Oka, Hirohito"' showing total 8 results
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8 results on '"Oka, Hirohito"'

2. Dynamics and energetics of the base flipping conformation studied with base pair-mimic nucleosides

Author

Nakano, Shu-ichi, Oka, Hirohito, Uotani, Yuuki, Uenishi, Kazuya, Fujii, Masayuki, and Sugimoto, Naoki

Subjects
Adenosine -- Chemical properties, DNA repair -- Analysis, Naphthalene -- Chemical properties, Naphthalene -- Structure, Nucleosides -- Chemical properties, Biological sciences, Chemistry
Abstract

Base flipping induced by the base pair analogues of deoxyadenosine and deoxycytidine derivatives tethering a phenyl or naphthyl group was explored to study the dynamics and energetics of unusual conformation observed during DNA repair and DNA and RNA modification processes. The results for the base flipping which occurred in competition with base pair formation could be applied to study the base flipping conformation under the equilibrium with base pairing.

Published
2009

6. Conformation and the sodium ion condensation on DNA and RNA structures in the presence of a neutral cosolute as a mimic of the intracellular media

Author

Nakano, Shu-ichi, primary, Wu, Lei, additional, Oka, Hirohito, additional, Karimata, Hisae Tateishi, additional, Kirihata, Toshimasa, additional, Sato, Yuichi, additional, Fujii, Satoshi, additional, Sakai, Hiroshi, additional, Kuwahara, Masayuki, additional, Sawai, Hiroaki, additional, and Sugimoto, Naoki, additional

Published
2008
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8. Functionalization of DNA by the base pair-mimic nucleosides

Author

Oka, Hirohito, Nakano, Shu-ichi, Uotani, Yuuki, Uenishi, Kazuya, Fujii, Masayuki, and Sugimoto, Naoki

Abstract

We developed the base pair-mimic nucleosides tethering the phenyl group and the naphtyl group, synthesized from deoxyadenosine (Aphe and Anaph) and deoxycytidine (Cphe and Cnaph). Structure and the thermal stability of the DNA duplexes containing the deoxyadenosine derivatives or the deoxycytidine ones in the middle of a DNA strand were obtained by the CD spectra and the UV melting curves. The ΔGo37 values among DNA duplexes containing Aphe-A, Aphe-G, Aphe-C and Aphe-T pair differed only by 1.9 kcal mol−1. The DNA duplexes containing Cphe also showed the ΔGo37 values differed by 1.0 kcal mol-1 despite opposite base nucleotide, except the duplex containing the Cphe-G pair. Interestingly, the duplex consisting of the DNA containing the base pair-mimic nucleosides and the complementary RNA strand caused the site-selective RNA hydrolysis except the Cphe-G pair. This data suggests that the Cphe has an ability of forming the base pair with guanosine.

Published
2007
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