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6. ACERVO PUNK

Author

Oliveira, Antônio Carlos de, primary and Pires, João Augusto Neves, primary

Published
2021
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9. Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- and age-related behavioral and immune/neurotrophic alterations in mice : relevance to autism spectrum disorders

Author

Custódio, Charllyany Sabino, Mello, Bruna Stefânia Ferreira, Chaves Filho, Adriano José Maia, Lima, Camila Nayane de Carvalho, Cordeiro, Rafaela Carneiro, Miyajima, Fábio Miyajima, Vasconcelos, Silvânia Maria Mendes, Barichello, Tatiana, Quevedo, João, Oliveira, Antônio Carlos de, Lucena, David Freitas de, Réus, Gislaine Z., and Macedo, Danielle S.

Subjects
Autismo, Caracteres Sexuais, Sex Differences
Abstract

Early-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic factor—BDNF) alterations were determined in the prefrontal cortex (PFC), hippocampus (HC), and hypothalamus (HT). Since the incidence and clinical manifestations of neurodevelopmental disorders present significant sex-related differences, we sought to distinctly evaluate male and female mice. While on PN35, LPS-challenged male mice presented depressive, anxiety-like, repetitive behavior, and working memory deficits; on PN70, only depressive- and anxiety-like behaviors were observed. Conversely, females presented

Published
2017

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