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555 results on '"Otero, Miguel"'

1. New methods of neutrino and anti-neutrino detection from 0.115 to 105 MeV

Author

Solomey, Nickolas, Christl, Mark, Doty, Brian, Folkerts, Jonathan, Hartsock, Brooks, Kuznetsco, Evgen, McTaggart, Robert, Meyer, Holger, Nolan, Tyler, Pawloski, Greg, Reichart, Daniel, Rodriguez-Otero, Miguel, Smith, Dan, and Solomey, Lisa

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

We have developed a neutrino detector with threshold energies from ~0.115 to 105 MeV in a clean detection mode almost completely void of accidental backgrounds. It was initially developed for the NASA $\nu$SOL project to put a solar neutrino detector very close to the Sun with 1,000 to 10,000 times higher solar neutrino flux than on Earth. Similar interactions have been found for anti-neutrinos, which were initially intended for Beta decay neutrinos from reactors, geological sources, or for nuclear security applications. These techniques work at the 1 to 100 MeV region for neutrinos from the ORNL Spallation Neutron Source or low energy accelerator neutrino and anti-neutrino production targets less than $\sim$100 MeV. The identification process is clean, with a double pulse detection signature within a time window between the first interaction producing the conversion electron or positron and the secondary gamma emission 100 ns to ~1 $\mu$s, which removes most accidental backgrounds. These new modes for neutrino and anti-neutrino detection of low energy neutrinos and anti-neutrinos could allow improvements to neutrino interaction measurements from an accelerator beam on a target., Comment: Contribution to the 25th International Workshop on Neutrinos from Accelerators

Published
2024

2. Gamma Ray Detection Efficiency of GAGG Crystal Scintillator Using Three Tagged Gamma Ray Techniques

Author

Doty, Brian, Solomey, Nickolas, Folkerts, Jonathan, Hartsock, Brooks, Meyer, Holger, Christl, Mark, Rodriguez-Otero, Miguel, and Kuznetsov, Evgeny

Subjects
Physics - Instrumentation and Detectors
Abstract

A CubeSat with a prototype scintillating detector with a sensitive volume of GAGG crystal is being developed with a possible launch date of 2025. Its purpose is to characterize the background signals that mimic the neutrino interaction that the nuSOL team is looking for. An important part of the characterization of the backgrounds and the expected real signal is understanding the gamma ray detection efficiency of the prototype detector. To this end we have used and developed three techniques to do an absolute measurement of gamma ray efficiency. The first is using EC sources that emit an X-ray before prompt emission of a de-excitation gamma ray, specifically Zn-65 and Mn-54. The second is using a beta + decay source wherein a positron annihilates on an atomic shell electron producing two back-to-back 511 keV gammas followed promptly by a de-excitation gamma, specifically Na-22. The third is using a gamma cascade of two near-simultaneous de-excitation gammas from the same nucleus, specifically from Co-60 decay., Comment: 27 pages. 29 Figures. This is soon to be a Nuclear Instruments and Methods Article

Published
2024

3. Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue

Author

Bell, Richard D., Brendel, Matthew, Konnaris, Maxwell A., Xiang, Justin, Otero, Miguel, Fontana, Mark A., Bai, Zilong, Krenitsky, Daria M., Meednu, Nida, Rangel-Moreno, Javier, Scheel-Toellner, Dagmar, Carr, Hayley, Nayar, Saba, McMurray, Jack, DiCarlo, Edward, Anolik, Jennifer H., Donlin, Laura T., Orange, Dana E., Kenney, H. Mark, Schwarz, Edward M., Filer, Andrew, Ivashkiv, Lionel B., and Wang, Fei

Published
2024
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6. Clinical and biobehavioral phenotypic assessments and data harmonization for the RE-JOIN research consortium: Recommendations for common data element selection

Author

Cruz-Almeida, Yenisel, Mehta, Bella, Haelterman, Nele A., Johnson, Alisa J., Heiting, Chloe, Ernberg, Malin, Orange, Dana, Lotz, Martin, Boccanfuso, Jacqueline, Smith, Shad B., Pela, Marlena, Boline, Jyl, Otero, Miguel, Allen, Kyle, Perez, Daniel, Donnelly, Christopher, Almarza, Alejandro, Olmer, Merissa, Balkhi, Henah, Wagenaar, Joost, and Martone, Maryann

Published
2024
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14. The human nucleoporin Tpr protects cells from RNA-mediated replication stress

Author

Kosar, Martin, Giannattasio, Michele, Piccini, Daniele, Maya-Mendoza, Apolinar, García-Benítez, Francisco, Bartkova, Jirina, Barroso, Sonia I., Gaillard, Hélène, Martini, Emanuele, Restuccia, Umberto, Ramirez-Otero, Miguel Angel, Garre, Massimiliano, Verga, Eleonora, Andújar-Sánchez, Miguel, Maynard, Scott, Hodny, Zdenek, Costanzo, Vincenzo, Kumar, Amit, Bachi, Angela, Aguilera, Andrés, Bartek, Jiri, and Foiani, Marco

Published
2021
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18. Incidence of patella baja and pseudopatella baja in aseptic revision total knee arthroplasty.

Author

Flevas, Dimitrios A., Brenneis, Marco, Bauer, Thomas, Bogner, Eric, Bostrom, Mathias, Cross, Michael, Figgie, Mark, Haas, Steven, Ivashkiv, Lionel, Jerabek, Seth, Jules-Elysee, Kethy, Kirksey, Meghan, Koff, Matthew, Konnaris, Maxwell, Lessard, Samantha, Mayman, David, McLawhorn, Alexander, Mukherjee, Piali, Oliver, David, and Otero, Miguel

Subjects
TOTAL knee replacement, PATELLA, PATELLA dislocation, REOPERATION, MEDICAL personnel, RANGE of motion of joints, KNEE pain
Abstract

Introduction: There are two variants regarding the low location of the patella in relation to the tibio-femoral joint line: patella baja (PB) and pseudo-patella baja (PPB). The purpose of this study is to investigate the incidence of PB and PPB in a cohort of patients that underwent revision total knee arthroplasty (rTKA) for aseptic reasons and describe any differences in each group's ROM. Methods: This retrospective study included 114 patients that underwent aseptic revision TKA surgery between 2017 and 2022. Patients were revised either for stiffness (Group 1) or aseptic loosening/instability (Group 2). The Insall-Salvati ratio (ISR) and Blackburne-Peel ratio (BPR) were used to evaluate the patellar position. ISR < 0.8 defined PB, while cases with ISR ≥ 0.8 and BPI < 0.54 were defined as PPB. ROM was measured and a subanalysis was conducted to investigate the progression of the values of ISR and BPR. Results: 55 patients comprised Group 1, and 59 patients comprised Group 2. Overall, 13 cases (11.4%) had PB before rTKA and 24 (21%) had PB after rTKA. Cases with PPB were 13 (11.4%) before and 34 (29.9%) after rTKA. Group 1 patients presented with more PB before and after rTKA (12.8% vs 10.2% and 27.3% vs 15.2% respectively). However, after rTKA Group 1 patients presented with less PPB (20%) compared to Group 2 (39%) (p = 0.02). In Group 1, patients with PPB after rTKA had less ROM compared to those without PPB [83.2 (± 21.9) vs 102.1 (± 19.9) (p = 0.025)]. The subanalysis (69 patients) showed a statistically significant decrease in ISR before and after rTKA (p = 0.041), and from the native knee to post-rTKA (p = 0.001). There was a statistically significant decrease in BPR before and after rTKA (p = 0.001) and from the native knee to both pre- and post-rTKA (p < 001). Conclusion: After undergoing rTKA, the incidences of both patella baja (PB) and pseudo-patella baja (PPB) increased. Stiffness in the knee was associated with a higher incidence of PB, while non-stiffness cases showed a significantly higher incidence of PPB. Patients with stiff knees and PPB after rTKA experienced a significant reduction in range of motion (ROM). Additionally, the study revealed a noteworthy decrease in ISR and BPR with each subsequent surgery. This information is crucial for healthcare providers, as it sheds light on potential risks and outcomes of rTKA, allowing for improved patient management and surgical decision-making. Level of evidence: III. [ABSTRACT FROM AUTHOR]

Published
2024
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23. ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes

Author

Hall, Katherine C, Hill, Daniel, Otero, Miguel, Plumb, Darren A, Froemel, Dara, Dragomir, Cecilia L, Maretzky, Thorsten, Boskey, Adele, Crawford, Howard C, Selleri, Licia, Goldring, Mary B, and Blobel, Carl P

Subjects
Biochemistry and Cell Biology, Biological Sciences, 2.1 Biological and endogenous factors, Aetiology, ADAM Proteins, ADAM17 Protein, Animals, Apoptosis, Bone and Bones, Calcification, Physiologic, Cartilage, Cell Differentiation, Cell Proliferation, Cells, Cultured, Chondrocytes, ErbB Receptors, Gene Deletion, Growth Plate, Heparin-binding EGF-like Growth Factor, Hypertrophy, Intercellular Signaling Peptides and Proteins, Male, Mice, Osteoclasts, Osteogenesis, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Endochondral ossification is a highly regulated process that relies on properly orchestrated cell-cell interactions in the developing growth plate. This study is focused on understanding the role of a crucial regulator of cell-cell interactions, the membrane-anchored metalloproteinase ADAM17, in endochondral ossification. ADAM17 releases growth factors, cytokines, and other membrane proteins from cells and is essential for epidermal growth factor receptor (EGFR) signaling and for processing tumor necrosis factor alpha. Here, we report that mice lacking ADAM17 in chondrocytes (A17ΔCh) have a significantly expanded zone of hypertrophic chondrocytes in the growth plate and retarded growth of long bones. This abnormality is caused by an accumulation of the most terminally differentiated type of chondrocytes that produces a calcified matrix. Inactivation of ADAM17 in osteoclasts or endothelial cells does not affect the zone of hypertrophic chondrocytes, suggesting that the main role of ADAM17 in the growth plate is in chondrocytes. This notion is further supported by in vitro experiments showing enhanced hypertrophic differentiation of primary chondrocytes lacking Adam17. The enlarged zone of hypertrophic chondrocytes in A17ΔCh mice resembles that described in mice with mutant EGFR signaling or lack of its ligand transforming growth factor α (TGFα), suggesting that ADAM17 regulates terminal differentiation of chondrocytes during endochondral ossification by activating the TGFα/EGFR signaling axis.

Published
2013

24. Patient-Associated Predictors of 15- and 30-Day Readmission After Hospitalization for Acute Heart Failure

Author

Delgado, Juan F., Ferrero Gregori, Andreu, Fernández, Laura Morán, Claret, Ramón Bascompte, Sepúlveda, Andrés Grau, Fernández-Avilés, Francisco, González-Juanatey, José R., García, Rafael Vázquez, Otero, Miguel Rivera, Segovia Cubero, Javier, Pascual Figal, Domingo, Crespo-Leiro, Maria G., Alvarez-García, Jesús, Cinca, Juan, and Ynsaurriaga, Fernando Arribas

Published
2019
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28. Desarrollo de una escala diagnóstica para histoplamosis en una cohorte de pacientes con VIH

Author

Hoyos Pulgarín, Julián Andrés, Atehortua Otero, Miguel Ángel, Hoyos Pulgarín, Julián Andrés, and Atehortua Otero, Miguel Ángel

Abstract

La histoplasmosis diseminada constituye la forma más severa de presentación de la histoplasmosis. Ésta es más frecuente en pacientes con deterioro de la función inmune, siendo la infección por VIH un factor de riesgo reconocido para su desarrollo. En este grupo de pacientes el diagnóstico es un reto dado lo inespecífico del cuadro clínico y hallazgos paraclínicos, retrasando así el inicio de la terapia apropiada y disminuyendo la posibilidad de sobrevida de estos pacientes. La intención de este estudio fue desarrollar una escala predictiva diagnóstica para histoplasmosis diseminada en pacientes con VIH atendidos en dos instituciones de tercer nivel de la ciudad de Pereira., Disseminated Histoplasmosis (DH) is more common in patients with impaired immune function, with HIV infection being a recognized risk factor for its development. In this patient group, diagnosis poses a challenge due to the nonspecific clinical picture. We aimed to develop a diagnostic predictive scale for DH in HIV patients.

Published
2023

29. Modelling metastasis in zebrafish unveils regulatory interactions of cancer-associated fibroblasts with circulating tumour cells

Author

Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física, Hurtado, Pablo, Martínez Pena, Inés, Yepes-Rodríguez, Sabrina, Bascoy-Otero, Miguel, Abuín, Carmen, Fernández-Santiago, Cristóbal, Sánchez Piñón, Laura, López López, Rafael, Piñeiro, Roberto, Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física, Hurtado, Pablo, Martínez Pena, Inés, Yepes-Rodríguez, Sabrina, Bascoy-Otero, Miguel, Abuín, Carmen, Fernández-Santiago, Cristóbal, Sánchez Piñón, Laura, López López, Rafael, and Piñeiro, Roberto

Abstract

The dynamic intercommunication between tumour cells and cells from the microenvironment, such as cancer-associated fibroblast (CAFs), is a key factor driving breast cancer (BC) metastasis. Clusters of circulating tumour cells (CTCs), known to bare a higher efficiency at establishing metastases, are found in the blood of BC patients, often accompanied by CAFs in heterotypic CTC-clusters. Previously we have shown the utility of CTC-clusters models and the zebrafish embryo as a model of metastasis to understand the biology of breast cancer CTC clusters. In this work, we use the zebrafish embryo to study the interactions between CTCs in homotypic clusters and CTC-CAFs in heterotypic CTC-clusters to identify potential pro-metastatic traits derived from CTC-CAF communication. We found that upon dissemination CAFs seem to exert a pro-survival and pro proliferative effect on the CTCs, but only when CTCs and CAFs remain joined as cell clusters. Our data indicate that the clustering of CTC and CAF allows the establishment of physical interactions that when maintained over time favour the selection of CTCs with a higher capacity to survive and proliferate upon dissemination. Importantly, this effect seems to be dependent on the survival of disseminated CAFs and was not observed in the presence of normal fibroblasts. Moreover, we show that CAFs can exert regulatory effects on the CTCs without being involved in promoting tumour cell invasion. Lastly, we show that the physical communication between BC cells and CAFs leads to the production of soluble factors involved in BC cell survival and proliferation. These findings suggest the existence of a CAF-regulatory effect on CTC survival and proliferation sustained by cell-to-cell contacts and highlight the need to understand the molecular mechanisms that mediate the interaction between the CTCs and CAFs in clusters enhancing the metastatic capacity of CTCs.

Published
2023

36. Adaptive immune responses in patients requiring revision after total knee arthroplasty

Author

Jenkins, Daniel, primary, Phalke, Swati, additional, Bell, Richard, additional, Lessard, Samantha, additional, Gupta, Sanjay, additional, Youssef, Mark, additional, Tam, Kathleen, additional, Nocon, Allina, additional, Rivera‐Correa, Juan, additional, Wright, Timothy, additional, Sculco, Thomas, additional, Otero, Miguel, additional, Pernis, Alessandra B., additional, and Sculco, Peter, additional

Published
2022
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40. Contributors

Author

Abramson, Steven, primary, An, KaiNan, additional, Andrade, Felipe, additional, Ardoin, Stacy P., additional, Barton, Anne, additional, Baughman, Robert P., additional, Beaton, Dorcas E., additional, Beere, Helen M., additional, Beltran, Javier, additional, Bending, David, additional, Bennett, Robert M., additional, Bermas, Bonnie L., additional, Bertsias, George, additional, Bhardwaj, Nina, additional, Bijlsma, Johannes W.J., additional, Bockenstedt, Linda K., additional, Boers, Maarten, additional, Boilard, Eric, additional, Boin, Francesco, additional, Boumpas, Dimitrios T., additional, Boyle, David L., additional, Bradley, Sean, additional, Brown, Matthew, additional, Buch, Maya, additional, Buckley, Christopher D., additional, Budd, Ralph C., additional, Burg, Nathalie, additional, Burns, Christopher M., additional, Cannella, Amy C., additional, Carter, John D., additional, Chakravarty, Eliza F., additional, Chakravarty, Soumya D., additional, Chang, Christopher, additional, Cheng, Joseph S., additional, Chiodo, Christopher P., additional, Chung, Sharon, additional, Cleland, Leslie G., additional, Cohen, Stanley, additional, Colbert, Robert A., additional, Cook, Paul P., additional, Craft, Joseph E., additional, Crofford, Leslie J., additional, Cronstein, Bruce N., additional, Crow, Mary K., additional, Crowson, Cynthia S., additional, Culley, Kirsty L., additional, Cunnane, Gaye, additional, Dall'Era, Maria, additional, Darrah, Erika, additional, Davis, John M., additional, Bari, Cosimo De, additional, Dell'Accio, Francesco, additional, Diamond, Betty, additional, Di Cesare, Paul E., additional, Dixit, Rajiv, additional, Drenth, Joost P.H., additional, Dustin, Michael L., additional, El-Gabalawy, Hani S., additional, Elmamoun, Musaab, additional, Erickson, Alan R., additional, Erkan, Doruk, additional, Eyre, Stephen, additional, Fanouriakis, Antonis, additional, Felson, David T., additional, Field, Max, additional, Filer, Andrew, additional, Firestein, Gary S., additional, Fishman, Felicity G., additional, FitzGerald, Oliver, additional, Flaherty, John P., additional, Fors, César E., additional, Fortner, Karen A., additional, Gabriel, Sherine E., additional, Gasque, Philippe, additional, Gershwin, M. Eric, additional, Gladue, Heather S., additional, Goldring, Mary B., additional, Goldring, Steven R., additional, Golightly, Yvonne M., additional, Goodman, Stuart, additional, Gordon, Siamon, additional, Grassi, Walter, additional, Green, Douglas R., additional, Greenspan, Adam, additional, Gregersen, Peter, additional, Grimaldi, Christine, additional, Guilherme, Luiza, additional, Hajj-Ali, Rula A., additional, Haudenschild, Dominik R., additional, Hellmann, David B., additional, Holmdahl, Rikard, additional, Hsu, Joyce J., additional, Huddleston, James I., additional, Hudson, Alan P., additional, Huizinga, Thomas W.J., additional, Hunder, Gene G., additional, Iversen, Maura D., additional, Jacobs, Johannes W.G., additional, Jen, Ho, additional, Jordan, Joanne M., additional, Jorizzo, Joseph L., additional, Kalil, Jorge, additional, Kaufman, Kenton, additional, Kaufman, William S., additional, Kavanaugh, Arthur, additional, Keenan, Robert T., additional, Kenna, Tony, additional, Kerr, Darcy A., additional, Koch, Alisa E., additional, Kono, Dwight H., additional, Korsten, Peter, additional, Krakow, Deborah, additional, Krasnokutsky, Svetlana, additional, Lafeber, Floris P.J.G., additional, Lambert, Robert G.W., additional, Lane, Nancy E., additional, Langford, Carol A., additional, Laskin, Daniel M., additional, Layh-Schmitt, Gerlinde, additional, Lee, Lela A., additional, Lee, Tzielan C., additional, Lockshin, Michael D., additional, Lozada, Carlos J., additional, Lundberg, Ingrid E., additional, Luqmani, Raashid, additional, Luyten, Frank P., additional, Mader, Reuven, additional, Maksymowych, Walter, additional, Markenson, Joseph A., additional, Martin, Scott David, additional, Matteson, Eric L., additional, McGregor, Laura, additional, McInnes, Iain B., additional, McNamara, Elizabeth K., additional, Mikuls, Ted R., additional, Miller, Mark S., additional, Ming, Pedro Azevedo, additional, Moder, Kevin G., additional, Monach, Paul A., additional, Moulton, Vaishali R., additional, Nagaraju, Kanneboyina, additional, Nelson, Amanda E., additional, Nigrovic, Peter A., additional, Nistala, Kiran, additional, O'Dell, James R., additional, Okada, Yasunori, additional, Østergaard, Mikkel, additional, Otero, Miguel, additional, Palmer, Bradley M., additional, Panush, Richard S., additional, Peng, Stanford L., additional, Pillai, Shiv, additional, Pillinger, Michael H., additional, Plüddemann, Annette, additional, Polston, Gregory R., additional, Porcelli, Steven A., additional, Price, Mark D., additional, Reed, Ann M., additional, Reveille, John D., additional, Robinson, Angela B., additional, Robinson, Philip, additional, Robinson, William H., additional, Roosendaal, Goris, additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rosenberg, Andrew E., additional, Ruderman, Eric M., additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Sammaritano, Lisa R., additional, Samuels, Jonathan, additional, Sandborg, Christy I., additional, Sawalha, Amr H., additional, Saxena, Amit, additional, Schett, Georg, additional, Schutgens, Roger E.G., additional, Seldin, David C., additional, Shah, Binita, additional, Sikora, Keith A., additional, Simon, Anna, additional, Siraj, Dawd S., additional, Sorkin, Linda S., additional, St. Clair, E. William, additional, Stamp, Lisa K., additional, Stone, John H., additional, Suarez-Fueyo, Abel, additional, Svensson, Camilla I., additional, Sweiss, Nadera J., additional, Swigart, Carrie R., additional, Szekanecz, Zoltán, additional, Tait, Stephen, additional, Tanne, Antoine, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Theofilopoulos, Argyrios N., additional, Thornhill, Thomas S., additional, Torok, Kathryn S., additional, Toth, Michael J., additional, Tozman, Elaine C., additional, Trouw, Leendert A., additional, Tsokos, George C., additional, Tugwell, Peter, additional, Tutuncu, Zuhre, additional, Upadhyaya, Shivam, additional, Van, Annette H.M., additional, van der Linden, Sjef, additional, Van, Jos W.M., additional, Van, Jacob M., additional, Meter, Heather Van, additional, van Vollenhoven, Ronald F., additional, van Vulpen, Lize F.D., additional, Varga, John, additional, Vaseer, Samera, additional, Vasquez-Castellanos, Raul, additional, Veale, Douglas J., additional, Wakefield, Richard J., additional, Wallace, Mark S., additional, Wang, Ruoning, additional, Wang, Tingting, additional, Warshaw, David M., additional, Wedderburn, Lucy R., additional, Werth, Victoria P., additional, Wigley, Fredrick M., additional, Wofsy, David, additional, Wollheim, Frank A., additional, Wondimu, Elisabeth, additional, Wong, Cyrus, additional, Wortmann, Robert L., additional, Yelin, Edward, additional, Zayat, Ahmed, additional, Zou, Yong-Rui, additional, and Zurier, Robert B., additional

Published
2017
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43. A Previously Unrecognized Molecular Landscape of Lynch Syndrome in the Mexican Population

Author

Padua-Bracho, Alejandra, primary, Velázquez-Aragón, José A., additional, Fragoso-Ontiveros, Verónica, additional, Nuñez-Martínez, Paulina María, additional, Mejía Aguayo, María de la Luz, additional, Sánchez-Contreras, Yuliana, additional, Ramirez-Otero, Miguel Angel, additional, De la Fuente-Hernández, Marcela Angélica, additional, Vidal-Millán, Silvia, additional, Wegman-Ostrosky, Talia, additional, Pedroza-Torres, Abraham, additional, Arriaga-Canon, Cristian, additional, Herrera-Montalvo, Luis A., additional, and Alvarez-Gómez, Rosa Maria, additional

Published
2022
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44. Poster 203: Mechanical Loading Effects on OA Progression Following ACL Injury and Reconstruction in a Murine Model: Radiographic Assessment of Synovial Fibroblast Activity

Author

Eliasberg, Claire, primary, Chen, Tony, additional, Kelly, James, additional, Havasy, Janice, additional, Piacentini, Alexander, additional, Liu, Yulei, additional, Singh, Purva, additional, Morita, Wataru, additional, Caughey, Sarah, additional, Fung, Edward, additional, Otero, Miguel, additional, Babich, John, additional, Rodeo, Scott, additional, and Carballo, Camila, additional

Published
2022
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46. El simbolismo primorriverista y nacionalcatólico a través de las actas municipales. Breve caso de la provincia de Alicante

Author

Lillo Otero, Miguel and Lillo Otero, Miguel

Abstract

La acción de la Dictadura se ve reflejada tanto en el plano material como en el simbólico, especialmente relevante este último para poder construir todo un relato. Esta acción simbólica a su vez se viene ejercida, como delegada, por parte de las corporaciones locales. Por tanto, a través del estudio de las actas municipales podremos referenciar y encontrar toda esa panoplia de actos y posicionamientos simbólicos que permiten observar la acción simbólica del primorriverismo y del nacionalcatolicismo, que promueve, en el plano local. Uno de los puntos que podemos definir claramente como un eje simbólico son los cambios del callejero, en donde se evidencia de forma explícita la apuesta por la memoria publica y por la construcción de un ideario publico claramente orientado.

Published
2022

47. Adaptive immune responses in patients requiring revision after total knee arthroplasty.

Author

Jenkins, Daniel, Phalke, Swati, Bell, Richard, Lessard, Samantha, Gupta, Sanjay, Youssef, Mark, Tam, Kathleen, Nocon, Allina, Rivera‐Correa, Juan, Wright, Timothy, Sculco, Thomas, Otero, Miguel, Pernis, Alessandra B., and Sculco, Peter

Subjects
TOTAL knee replacement, MONONUCLEAR leukocytes, IMMUNE response, SYNOVIAL fluid, PHOSPHOLIPID antibodies
Abstract

Dissatisfaction occurs in nearly 20% of patients after total knee arthroplasty (TKA); however, there remains only limited understanding of the biologic mechanisms that may contribute to suboptimal postoperative outcomes requiring revision surgery. Expansion of effector T and B cells, could promote an abnormal healing response via local or peripheral immune system mechanisms and contribute to inferior outcomes necessitating revision TKA. In this pilot study, we hypothesized that patients suffering from complications of arthrofibrosis or instability may exhibit differences in adaptive immune function. Patients (n = 31) undergoing revision TKA for an indication of arthrofibrosis or instability were prospectively enrolled. Whole blood and synovial fluid (SF) from the operative knee were collected at time of surgery. Peripheral blood mononuclear cells were isolated and analyzed by flow cytometry. Serum and SF were assessed for immunoglobulin levels by Luminex and antiphospholipid antibodies by enzyme‐linked immunoassay. No significant differences were observed in peripheral blood T/B cell populations or serum immunoglobulins levels between groups. SF analysis demonstrated significant differences between the two groups, with higher levels of immunoglobulin G1 (IgG1) (p = 0.0184), IgG3 (p = 0.0084) and antiphosphatidyl serine IgG (p = 0.034) in arthrofibrosis relative to instability patients. Increased levels of both IgG subclasses and antiphospholipid antibodies in the SF suggest that intra‐articular T‐B cell interactions, potentially triggered by exposure to apoptotic components generated during post‐op healing, could be functioning as a source of immune complexes that fuel fibrous tissue growth in arthrofibrotic patients. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Application of machine learning in the prediction of FDM part distortion based on finite element simulation

Author

Cortés Otero, Miguel and Gao, Chao

Abstract

FDM er den mest utbredte teknologien av alle additive produksjonsteknikker i dag. De siste årene har mye blitt fornyet når det gjelder nye materialer for FDM-trykk og prosessforbedringer. Dette har gjort at FDM ikke bare brukes til rask prototyping som før, men funksjonelle strukturer kan produseres ved hjelp av denne produksjonsteknikken. Imidlertid mangler denne trykkteknikken fortsatt dimensjonsnøyaktigh et for spesifikke bruksområder som krever høy nøyaktighet. I dette arbeidet presenteres en tilnærming for hvordan man kan forbedre dimensjonsnøyaktigh eten til FDM-trykte deler. Først lages et numerisk simuleringsrammeverk for additive produksjonsteknikker basert på Abaqus software (v. 2019 Simulia, Dassault Systems). Deformasjonene til tre forskjellige geometrier oppnås ved hjelp av det numeriske simuleringsrammever ket og analyseres. I tillegg utføres en studie av broken av maskinlæringsteknikk er for å forutsi FDM-delforvrengninger. FDM is the most widespread technology of all the additive manufacturing techniques nowadays. In recent years, much has been innovated in terms of new materials and process improvements for FDM printing. This has meant that FDM is not only used for rapid prototyping as before, but functional structures can be manufactured using this manufacturing technique. However, this printing technique still lacks dimensional accuracy for specific applications that require high accuracy. In this work, an approach of how to improve the dimensional accuracy of FDM printed parts is presented. First, a numerical simulation framework for additive manufacturing techniques is created based on Abaqus software (v. 2019 Simulia, Dassault Systems). The deformations of three different geometries are obtained and analysed using the numerical simulation framework. In addition, a study of the application of machine learning techniques to predict FDM part distortions is carried out.

Published
2022

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