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2. Persistent urogenital sinus with recto-vaginal fistula: the new variant in which the anus is normally positioned and literature review

Author

Hikmet Zeytun, Ahmet Demez, and Bulent Hayri Ozokutan

Subjects
Cloaca, Urogenital sinus, Dysgenesis, Fistula, Hydrocolpos, Pediatrics, RJ1-570, Surgery, RD1-811
Abstract

Abstract Background Persistent urogenital sinus is a rare cloacal anomaly in which the urinary and genital tracts cannot be differentiated during embryonic development. However, the presence of concomitant recto-urogenital sinus or recto-vaginal fistula is much rarer. In the literature, only two cases with accompanying fistula have been presented so far. Case presentation We present the diagnosis and treatment management of a persistent urogenital sinus case with recto-vaginal fistula. We also aimed to reveal the difference between our patient, who is the 3rd case in the literature, and the other two and the described cloacal anomalies. By performing total urogenital sinus mobilization and fistula repair, the three systems were separated from each other, and both a functional and cosmetic appearance was obtained. Conclusion It should be kept in mind that there may be different variants other than the defined cloacal malformations. In patients with cloacal malformation, cystoscopy and rectoscopy should be performed to reveal the anatomy before reconstructive surgery in order to avoid any unexpected situation.

Published
2023
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3. Dual Bankacılık Sisteminin Performans Endeksinin Oluşturulması ve İncelenmesi: Türkiye İçin Karşılaştırmalı Panel Veri Analizi

Author

Selim DEMEZ, Murat USTAOĞLU, and Ahmet İNCEKARA

Subjects
Islamic Finance, conventional banks, performance index, İslami Finans, konvansiyonel bankalar, performans analizi, Economics as a science, HB71-74
Abstract

Bankalar temel finansal işlemlerin dışında pek çok farklı çeşidi olan finansal enstrümanlarda üretmekte, vadeli işlem piyasalarından-hisse senedi piyasalarına kadar uzanan oldukça geniş yelpazade faaliyet göstermektedirler. Küreselleşme trendinin avantajlarından fazlasıyla istifade eden ve giderek sofisteki hale gelen finans sektörünün lokomotifi, mevduat bankacılığı olarak da bilinen, konvansiyonel bankacılık sistemidir. Faiz tabanlı konvansiyonel sistemin küresel ekonomi üzerindeki hegomanyasını sona erdirebilecek bir alternatiften, en azından yakın gelecekte, söz etmek mümkün değildir. Öte yandan bir kaç on yıl önce islam ülkelerinde temelleri atılan ve faizsiz kar-zarar ortaklığı (PLS) prensibi üzerine inşa edilen İslami bankacılık alternatif olarak öne çıkmakta ve giderek artan oranda konvensiyonel bankalarla karşılaştırmalı analizlere konu olmaktadır. Farklı değişken ve veri setlerinin yardımıyla yapılan çalışmalar sonucu elde edilen bulgular ışığında alınan tedbirler, yakın gelecekteki resesyon ve krizlerin olumsuz etkilerini minimize etmeye yardımcı olur. Bu çalışmada Türkiye’de faaliyet gösteren üç İslami ve dokuz konvansiyonel bankanın, 2008 küresel finans krizi sonrası döneminde, 2010-2015 yılları arasındaki performasnlarını panel data modeli yardımıyla analiz edilmiştir. Analiz sonucunda konvansiyonel bankaların performaslarını banka büyüklüğü, reservler, reel efektif döviz kuru, reel faiz oranı değişkenlerinin etkilediği görülürken, İslami bankaları banka büyüklüğü, mevduat oranı, rezervler, pazar yoğunluğu, , reel efektif döviz kuru, reel faiz oranı değişkenlerinin daha fazla etkilediği sonucuna varılmıştır.

Published
2018

4. BİR TOPLUMSAL İKTİDAR ALANI OLARAK BEDEN VE 'YAŞLANAN BEDENİN' YENİDEN İNŞAASI

Author

Meral Timurturkan and Gönül Demez

Subjects
yaşlılık, tüketim toplumu, yaşlanan beden, aging, consumer society, aging body, Social Sciences, Social sciences (General), H1-99
Abstract

İnsanın yaşamının normal döngüleri arasında bulunan yaşlılık günümüzde bir sosyal sorun olarak tanımlanarak kaçınılması, dolayısıyla geciktirilmesi gereken bir durum olarak algılanmaktadır. Bu durum yaşlılığın toplumsal boyutuna dikkatleri çeker. Çünkü yaşlılığı tanımlayan ve toplumsal hiyerarşide dezavantajlı alanda konumlandıran söz konusu toplumdaki iktidar ilişkilerini belirleyen egemen değerlerdir. Bu anlamda beden politikaları ve bedenin bir tüketim alanı olarak tüketim toplumundaki konumu da önemli olmaktadır. Buradan hareket eden bu çalışma, günümüz tüketim toplumunda yaşlanma ve yaşlılığı aktif çalışma yaşamında yer alamaması nedeniyle önce dışarıda bırakan yönüyle yeni bir ayrım biçimi olarak ele almaktadır. Ardından yine tüketim ilişkileri içine bir tüketici olarak dahil edilen yaşlılık kavramı sorgulanmaktadır. Yani bu çalışma kısaca toplumsal iktidar ilişkileri içinde yaşlılığa yüklenen anlamlar ile sosyal alanda iktidar kaybı olarak tanımlanan yaşlılığa dair pratiklerin piyasa ekonomisi odaklı olarak tartışılmasına dayanmaktadır.

Published
2018
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5. Trattamento delle stenosi laringee e tracheali dell’adulto

Author

K Sandu, A Lagier, F Gorostidi, and P Demez

Subjects
03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, 030223 otorhinolaryngology
Abstract

Riassunto Le stenosi laringee e tracheali sono un restringimento patologico della pervieta delle vie aeree di uno o piu piani della laringe (sovraglottico, glottico o subglottico) e/o della trachea cervicale o toracica. Sono all’origine di una dispnea rumorosa (stridore) e/o di una disfonia. Lo scopo della gestione e quello di evitare una tracheotomia o di essere in grado di svezzare il paziente dalla sua cannula, se ha gia subito una tracheotomia durante il trattamento. La decannulazione e, quindi, il criterio di successo della gestione terapeutica. La gestione e spesso chirurgica, endoscopica (dilatazioni, incisioni della stenosi con laser e cricotomie endoscopiche) oppure esterna (cricotomie, laringotracheoplastiche con interposizione di innesti cartilaginei anteriori e/o posteriori, resezioni cricotracheali e resezioni tracheali). Vengono discussi i principi di queste diverse tecniche e il loro ruolo all’interno della gestione terapeutica. Le indicazioni terapeutiche devono tenere conto dello stato di salute del paziente, spesso associato a comorbilita piu o meno gravi che possono impedire una cicatrizzazione senza recidiva di stenosi. La prevenzione delle stenosi laringotracheali, quando e possibile, deve sempre essere considerata.

Published
2020

6. Tratamiento de las estenosis laríngeas y traqueales del adulto

Author

P Demez, A Lagier, F Gorostidi, and K Sandu

Subjects
03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, 030223 otorhinolaryngology
Abstract

Resumen Las estenosis laringeas y traqueales son un estrechamiento patologico de la via aerea de una o de varias regiones de la laringe (supraglotica, glotica o subglotica) y/o de la traquea cervical o toracica. Provocan una disnea ruidosa (estridor) y/o disfonia. El objetivo del tratamiento es evitar una traqueotomia o lograr que el paciente prescinda de su canula si ya se realizo una traqueotomia durante el tratamiento. En este caso, la descanulacion es el criterio de exito terapeutico. El tratamiento suele ser quirurgico, por via endoscopica (dilataciones, incisiones de la estenosis con laser, cricotomias endoscopicas) o externa (cricotomias, laringotraqueoplastias con interposicion de injertos cartilaginosos anterior y/o posterior, resecciones cricotraqueales, resecciones traqueales). En este articulo se describen los principios de estas diferentes tecnicas y su lugar en el tratamiento. Las indicaciones terapeuticas deben tener en cuenta las caracteristicas del paciente, asociadas a menudo a enfermedades concurrentes mas o menos graves que pueden impedir una cicatrizacion sin recidiva de la estenosis. La prevencion de las estenosis laringotraqueales se debe plantear siempre que sea posible.

Published
2020

7. Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases

Author

A. Varoquaux, L. Castillo, M. Tassart, R. Jankowski, Emmanuelle Uro-Coste, F. Massip, L. Brugel, S Testelin, René-Jean Bensadoun, Olivier Mauvais, C. Bach, P. Herman, Christian-Adrien Righini, Laurent Gilain, Xavier Dufour, T. Mom, L. Laccoureye, E. Baudin, Justin Michel, Ludovic Le Taillandier de Gabory, G. Moulin, D. de Raucourt, C. Ferron, Juliette Thariat, R. Breheret, J.-M. Badet, V. Darrouzet, Bruno Devauchelle, T. Radulesco, Bertrand Baujat, V. Strunski, G. Poissonnet, Thomas Radulesco, Jean-Claude Merol, Renaud Garrel, C. Borel, A. Cosmidis, Odile Casiraghi, Dominique Chevalier, E. Serrano, Caroline Even, J.-C. Merol, P. Demez, L. Geoffrois, N. Fakhry, J.-P. Lavieille, A. Banal, J. Lacau St Guily, S. Duflo, J.-P. Bessède, B. Baujat, Marie Christine Kaminsky, F. Chabolle, Sebastien Albert, Roch Giorgi, O. Sterkers, N. Sarroul, Vianney Bastit, D. Blanchard, P. Lang, E. de Monès, P. Breton, G. Dolivet, R. Garrel, Sébastien Vergez, B. Toussaint, Anne Sudaka, A. Giovanni, G. Noel, P. Hofman, A. Bozorg-Grayeli, O. Malard, M. Housset, E. Lartigau, P. Ceruse, Valérie Costes-Martineau, C. Bertolus, Cécile Badoual, G. Andry, T. Van den Abbeele, F. Kolb, S. Faivre, F. Floret, P. Dessi, M. Juliéron, Nicolas Fakhry, J. Michel, Louis Crampette, Francois Mouawad, O. Choussy, Philippe Schultz, S. Hans, Marine Lefevre, L. Gilain, Emile Reyt, Sylvain Morinière, Philippe Herman, G. Valette, Béatrix Barry, A. Timochenko, Gilles Poissonnet, Antoine Moya-Plana, F. Veillon, S. Vergez, A. Coste, Franck Jegoux, E. Cassagnau, Christine Bach, Y. Marie Robin, B. Guerrier, E. Uro Coste, X. Leroy, Valérie Costes, Olivier Malard, F. Rolland, F. Dubrulle, A.C. Baglin, L. de Gabory, B. Ruhin, A. Girod, G. Calais, Laurie Saloner Dahan, Emmanuel Babin, J.C. Chobaut, Michel Wassef, Benjamin Lallemant, Jean-Michel Prades, C.-A. Righini, Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Aix Marseille Université (AMU), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Biostatistique et technologies de l'information et de la communication (BioSTIC) - [Hôpital de la Timone - APHM] (BiosTIC ), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Toulouse [Toulouse], CHU Bordeaux [Bordeaux], CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Institut Universitaire de la Face et du Cou [Nice], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre hospitalier universitaire de Nantes (CHU Nantes), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Hôpital Foch [Suresnes], CHU Lille, Centre Hospitalier Universitaire de Reims (CHU Reims), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), CHU Clermont-Ferrand, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Universitaire [Grenoble] (CHU), Institut Gustave Roussy (IGR), Département de cancérologie cervico-faciale [Gustave Roussy] (CCF), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), REFCOR members: S Albert, G Andry, E Babin, C Bach, J-M Badet, C Badoual, A C Baglin, A Banal, B Barry, E Baudin, B Baujat, R J Bensadoun, C Bertolus, J-P Bessède, D Blanchard, C Borel, A Bozorg-Grayeli, R Breheret, P Breton, L Brugel, G Calais, O Casiraghi, E Cassagnau, L Castillo, P Ceruse, F Chabolle, D Chevalier, J C Chobaut, O Choussy, A Cosmidis, A Coste, V Costes, L Crampette, V Darrouzet, P Demez, P Dessi, B Devauchelle, G Dolivet, F Dubrulle, S Duflo, X Dufour, S Faivre, N Fakhry, C Ferron, F Floret, L de Gabory, R Garrel, L Geoffrois, L Gilain, A Giovanni, A Girod, B Guerrier, S Hans, P Herman, P Hofman, M Housset, R Jankowski, F Jegoux, M Juliéron, M-C Kaminsky, F Kolb, J Lacau St Guily, L Laccoureye, B Lallemant, P Lang, E Lartigau, J-P Lavieille, M Lefevre, X Leroy, O Malard, F Massip, O Mauvais, J-C Merol, J Michel, T Mom, S Morinière, E de Monès, G Moulin, G Noel, G Poissonnet, J-M Prades, T Radulesco, D de Raucourt, E Reyt, C Righini, Y Marie Robin, F Rolland, B Ruhin, N Sarroul, P Schultz, E Serrano, O Sterkers, V Strunski, A Sudaka, M Tassart, S Testelin, J Thariat, A Timochenko, B Toussaint, E Uro Coste, G Valette, T Van den Abbeele, A Varoquaux, F Veillon, S Vergez, M Wassef, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Equipe IFTIM [ImViA - EA7535], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Imagerie et Vision Artificielle [Dijon] (ImViA), Université de Bourgogne (UB)-Université de Bourgogne (UB), Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), dormoy, valerian, Pathogénèse et contrôle des infections chroniques (PCCI), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )

Subjects
medicine.medical_specialty, Multivariate analysis, [SDV]Life Sciences [q-bio], Salivary glands, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Mucoepidermoid carcinoma, Internal medicine, Diabetes mellitus, Medicine, Stage (cooking), Intermediate Grade, 030223 otorhinolaryngology, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, Cancer, [PHYS]Physics [physics], business.industry, General Medicine, medicine.disease, 3. Good health, Parotid gland, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Surgery, business
Abstract

International audience; Background: To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival.Patients and methods: Patients with MEC were prospectively included in the Réseau d'Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015.Results: A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis.Conclusion: Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.

Published
2020

8. Stenosi laringee dell’adulto

Author

K Sandu, P Demez, A Lagier, and F Gorostidi

Subjects
03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, media_common.quotation_subject, Art, 030223 otorhinolaryngology, Humanities, media_common
Abstract

Le stenosi laringee e tracheali sono un restringimento patologico della filiera aerea di uno o piu piani della laringe (sopraglottico, glottico o sottoglottico) e/o della trachea cervicale o toracica. Esse sono all’origine di una disfonia per le stenosi glottiche che coinvolgono la commissura anteriore o di una dispnea rumorosa (stridore) per altre localizzazioni. L’obiettivo della gestione, in quest’ultimo caso, e evitare una tracheotomia o poter svezzare il paziente dalla cannula, se e gia tracheotomizzato durante la gestione. La decannulazione e, allora, il criterio del successo del trattamento. Le eziologie della stenosi laringotracheali sono molteplici, il piu delle volte iatrogene, in particolare postintubazione orotracheale o posttracheotomia, ma anche le cause autoimmuni e idiopatiche sono molto rappresentate. La gestione e spesso chirurgica, per via endoscopica o esterna. Le diverse tecniche e il loro posto nella gestione non sono affrontati qui, in quanto sono oggetto di un articolo dedicato. Le indicazioni terapeutiche si basano su una valutazione precisa non solo della stenosi, ma anche delle comorbilita associate. La prevenzione delle stenosi laringotracheali, laddove possibile, deve essere sempre presa in considerazione.

Published
2019

9. Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France

Author

A. Moya-Plana, A. Aupérin, R. Obongo, A. Baglin, F.R. Ferrand, B. Baujat, N. Saroul, O. Casiraghi, S. Vergez, P. Herman, F. Janot, J. Thariat, B. Vérillaud, L. de Gabory, S. Albert, G. Andry, E. Babin, C. Bach, J.-M. Badet, C. Badoual, A.C. Baglin, A. Banal, B. Barry, E. Baudin, R.J. Bensadoun, C. Bertolus, J.-P. Bessède, D. Blanchard, C. Borel, A. Bozorg-Grayeli, R. Breheret, P. Breton, L. Brugel, G. Calais, E. Cassagnau, L. Castillo, P. Ceruse, F. Chabolle, D. Chevalier, J.C. Chobaut, O. Choussy, A. Cosmidis, A. Coste, V. Costes, L. Crampette, V. Darrouzet, P. Demez, P. Dessi, B. Devauchelle, L. Digue, G. Dolivet, F. Dubrulle, S. Duflo, X. Dufour, C. Even, S. Faivre, N. Fakhry, C. Ferron, F. Floret, R. Garrel, L. Geoffrois, L. Gilain, A. Giovanni, A. Girod, B. Guerrier, S. Hans, P. Hofman, M. Housset, R. Jankowski, F. Jegoux, M. Juliéron, M.-C. Kaminsky, F. Kolb, J. Lacau St Guily, L. Laccoureye, B. Lallemant, P. Lang, E. Lartigau, J.-P. Lavieille, M. Lefevre, X. Leroy, O. Malard, F. Massip, O. Mauvais, J.-C. Merol, J. Michel, T. Mom, S. Morinière, E. de Monès, G. Moulin, G. Noel, G. Poissonnet, J.-M. Prades, D. de Raucourt, E. Reyt, C. Righini, Y. Marie Robin, F. Rolland, B. Ruhin, N. Sarroul, P. Schultz, E. Serrano, O. Sterkers, V. Strunski, A. Sudaka, M. Tassart, S. Testelin, A. Timochenko, B. Toussaint, E. Uro Coste, G. Valette, T. Van den Abbeele, A. Varoquaux, F. Veillon, M. Wassef, Institut Gustave Roussy (IGR), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Département de cancérologie cervico-faciale [Gustave Roussy] (CCF), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Clermont-Ferrand, Laboratorium für Physikalische Chemie (ETH-LPC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), French Rare Head and Neck Cancer Expert Network (REFCOR), Service d'Oto-Rhino-Laryngologie (O.R.L.) et de Chirurgie Cervico-Faciale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), French Rare Head and Neck Cancer Expert Network. (REFCOR), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Service d'ORL et de Chirurgie Cervico-Faciale (PARIS - BICHAT - ORL et CCF), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Médecine nucléaire, Département d'imagerie médicale [Gustave Roussy], Service d’ORL et de chirurgie cervico-faciale [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Paul Strauss de Lutte contre le Cancer (Strasbourg), Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Chambre Régionale d'Agriculture des Pays de la Loire, Service de chirurgie, Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service d’Otorhinolaryngologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Service d'ORL, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Département de chirurgie maxillofaciale et stomatologie [CHU d'Amiens-Picardie], CHU Amiens-Picardie, Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Service de Radiologie (LILLE - Radio), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de médecine gériatrique, CHU de Saint-Etienne, Université Paris 13 (UP13), Hôpital Pellegrin, Service d'ORL et chirurgie cervico-faciale, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service d'ORL et Chirurgie Cervico-Facial, Hôpital de la Timone [CHU - APHM] (TIMONE), Fluides, automatique, systèmes thermiques (FAST), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Géomatériaux (DGCB-LGM), École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie des réseaux sensorimoteurs (NRS (U7060)), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Centre méditérannéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), University of St Andrews [Scotland], Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER, Centre hospitalier universitaire de Nantes (CHU Nantes), Statistique en grande dimension pour la génomique, Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Reims (CHU Reims), Institut d'Electronique du Solide et des Systèmes (InESS), Centre National de la Recherche Scientifique (CNRS), Service d'ORL et de Chirurgie Cervico-Faciale (TOURS - ORL et CCF), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Rennes (UNIV-RENNES), Service de chirurgie oncologique cervico-faciale [centre Antoine Lacassagne, Nice], Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA), Department of Otolaryngology and Head and Neck Surgery, University Hospital of Grenoble, BP 217, 38043, Grenoble Cedex 09, France, Université Joseph Fourier - Grenoble 1 (UJF), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), CRLCC René Gauducheau, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Réhabilitation Chirurgicale mini-Invasive et Robotisée de l'Audition, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de cristallographie et sciences des matériaux (CRISMAT), École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC), Department of Head and Neck Surgery, Hôpital Larrey [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Service d'oto-rhino-laryngologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Biomécanique et génie biomédical (BIM), Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors (REFCOR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Université de Lille-UNICANCER, Université de Rennes (UR), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Les Hôpitaux Universitaires de Strasbourg (HUS), Service Chirurgie maxillo-faciale et plastique de la face [CHU Toulouse], Pôle Céphalique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Tours-Centre National de la Recherche Scientifique (CNRS), and Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Oncology, Male, Cancer Research, Multivariate analysis, medicine.medical_treatment, 0302 clinical medicine, Paranasal Sinuses, Medicine, Prospective Studies, Stage (cooking), Head and neck, Lymph node, Melanoma, Aged, 80 and over, Mucosal melanoma, Middle Aged, Prognosis, Progression-Free Survival, 3. Good health, Tumor Burden, Survival Rate, medicine.anatomical_structure, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Female, Mouth Neoplasms, France, Algorithms, Paranasal Sinus Neoplasms, Adult, medicine.medical_specialty, Nose Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Young Adult, Internal medicine, Humans, Sinonasal, Aged, Neoplasm Staging, Radiotherapy, business.industry, Head and neck cancer, Mouth Mucosa, medicine.disease, Otorhinolaryngologic Surgical Procedures, Oral cavity, Radiation therapy, Nasal Mucosa, 030104 developmental biology, Oral Cavity Mucosal Melanoma, Radiotherapy, Adjuvant, business
Abstract

International audience; BACKGROUND:Head and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal (sinonasal mucosal melanoma [SNMM]) and oral cavity (oral cavity mucosal melanoma [OCMM]). Consensual therapeutic guidelines considering the primary tumour site and tumour-node-metastasis (TNM) stage are not well established.MATERIAL & METHODS:Patients with HNMM from the prospective national French Rare Head and Neck Cancer Expert Network database between 2000 and 2017 were included. Clinical characteristics, treatment modalities, outcomes and prognostic factors were analysed.RESULTS:In total, 314 patients were included. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 49.4% and 24.7%, respectively, in the surgery group; no long-term survivors were observed when surgery was not feasible. Moreover, even after surgery, a high recurrence rate was reported with a median PFS of 22 months. In multivariate analysis, Union for International Cancer Control (UICC) stage and tumour site correlated with PFS and OS. Postoperative radiotherapy (PORT) improved the PFS but not OS in patients with small (T3) SNMM and OCMM tumours. Nodal involvement was more frequent in patients with OCMM (p < 10-4), although, as in SNMM, it was not a significant prognostic predictor.CONCLUSION:Even early HNMM was associated with poor oncologic outcomes due to distant metastases despite surgical resection with clear margins. Lymph node metastases had no impact on the prognosis, suggesting treatment de-escalation in cervical node management. PORT might be useful for local control.

Published
2019

10. Direct and indirect injuries of the pharynx and larynx

Author

J, Berget, M, Tonglet, P, Ransy, A, Gillet, V, D'Orio, P, Moreau, A, Ghuysen, and P, Demez

Subjects
Dyspnea, Humans, Pharynx, Endoscopy, Wounds, Penetrating, Airway Management, Larynx, Wounds, Nonpenetrating, Physical Examination, Neck
Abstract

Direct and indirect injuries of the pharynx and larynx. The neck is characterized by a relatively complex anatomy and a very compact content. It therefore forms an extremely vulnerable part of the human body. Although uncommon, aero-digestive tract injuries caused by trauma present a challenging situation for both the emergency doctor and the head and neck surgeon. Clinical presentations may vary from severe acute distress with immediate life-threatening airway obstruction to apparently more reassuring situations. However, the latter turn out to be frequently misleading, since patients may deteriorate suddenly as the result of unrecognized injuries. In such cases, delayed diagnosis is often associated with increased morbidity and mortality. Due to its role in phonation, breathing and alimentation, injuries to the aero-digestive tract also expose the patient to severe later impairment and a poorer quality of life. Comprehensive airway control remains the highest and often most challenging priority for the emergency physician. Careful clinical examination combined with endoscopy and computed tomography imaging form the key elements in diagnosis and early recognition of patients who may require surgical management.

Published
2018

11. Laringiti croniche

Author

L. Plisson, P. Demez, C. Dolfus, E. Lechapt, M. Hitier, and E. Babin

Published
2014

12. Trattamento delle stenosi laringee e tracheali dell’adulto

Author

Lagier, A., Gorostidi, F., Demez, P., and Sandu, K.

Abstract

Le stenosi laringee e tracheali sono un restringimento patologico della pervietà delle vie aeree di uno o più piani della laringe (sovraglottico, glottico o subglottico) e/o della trachea cervicale o toracica. Sono all’origine di una dispnea rumorosa (stridore) e/o di una disfonia. Lo scopo della gestione è quello di evitare una tracheotomia o di essere in grado di svezzare il paziente dalla sua cannula, se ha già subito una tracheotomia durante il trattamento. La decannulazione è, quindi, il criterio di successo della gestione terapeutica. La gestione è spesso chirurgica, endoscopica (dilatazioni, incisioni della stenosi con laser e cricotomie endoscopiche) oppure esterna (cricotomie, laringotracheoplastiche con interposizione di innesti cartilaginei anteriori e/o posteriori, resezioni cricotracheali e resezioni tracheali). Vengono discussi i principi di queste diverse tecniche e il loro ruolo all’interno della gestione terapeutica. Le indicazioni terapeutiche devono tenere conto dello stato di salute del paziente, spesso associato a comorbilità più o meno gravi che possono impedire una cicatrizzazione senza recidiva di stenosi. La prevenzione delle stenosi laringotracheali, quando è possibile, deve sempre essere considerata.

Published
2020
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13. Tratamiento de las estenosis laríngeas y traqueales del adulto

Author

Lagier, A., Gorostidi, F., Demez, P., and Sandu, K.

Abstract

Las estenosis laríngeas y traqueales son un estrechamiento patológico de la vía aérea de una o de varias regiones de la laringe (supraglótica, glótica o subglótica) y/o de la tráquea cervical o torácica. Provocan una disnea ruidosa (estridor) y/o disfonía. El objetivo del tratamiento es evitar una traqueotomía o lograr que el paciente prescinda de su cánula si ya se realizó una traqueotomía durante el tratamiento. En este caso, la descanulación es el criterio de éxito terapéutico. El tratamiento suele ser quirúrgico, por vía endoscópica (dilataciones, incisiones de la estenosis con láser, cricotomías endoscópicas) o externa (cricotomías, laringotraqueoplastias con interposición de injertos cartilaginosos anterior y/o posterior, resecciones cricotraqueales, resecciones traqueales). En este artículo se describen los principios de estas diferentes técnicas y su lugar en el tratamiento. Las indicaciones terapéuticas deben tener en cuenta las características del paciente, asociadas a menudo a enfermedades concurrentes más o menos graves que pueden impedir una cicatrización sin recidiva de la estenosis. La prevención de las estenosis laringotraqueales se debe plantear siempre que sea posible.

Published
2020
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14. Stenosi laringee dell’adulto

Author

Lagier, A., Gorostidi, F., Demez, P., and Sandu, K.

Abstract

Le stenosi laringee e tracheali sono un restringimento patologico della filiera aerea di uno o più piani della laringe (sopraglottico, glottico o sottoglottico) e/o della trachea cervicale o toracica. Esse sono all’origine di una disfonia per le stenosi glottiche che coinvolgono la commissura anteriore o di una dispnea rumorosa (stridore) per altre localizzazioni. L’obiettivo della gestione, in quest’ultimo caso, è evitare una tracheotomia o poter svezzare il paziente dalla cannula, se è già tracheotomizzato durante la gestione. La decannulazione è, allora, il criterio del successo del trattamento. Le eziologie della stenosi laringotracheali sono molteplici, il più delle volte iatrogene, in particolare postintubazione orotracheale o posttracheotomia, ma anche le cause autoimmuni e idiopatiche sono molto rappresentate. La gestione è spesso chirurgica, per via endoscopica o esterna. Le diverse tecniche e il loro posto nella gestione non sono affrontati qui, in quanto sono oggetto di un articolo dedicato. Le indicazioni terapeutiche si basano su una valutazione precisa non solo della stenosi, ma anche delle comorbilità associate. La prevenzione delle stenosi laringotracheali, laddove possibile, deve essere sempre presa in considerazione.

Published
2019
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15. Facial pain from visceral origin

Author

P, Demez, Y, Goffart, and J, Daele

Subjects
Male, Lung Neoplasms, Facial Pain, Earache, Humans, Aged
Abstract

Unilateral facial pain in the trigeminal area is known to be caused by a cancer in the superior lobe of the lung.A 65 year old male, heavy smoker, presented a permanent otalgia and a mandibular pain on the left side. These symptoms could not be relieved by common analgesics. All explorations for common etiologies were negative. After an episode of dyspnea, a left lung cancer was discovered. Thanks to radiotherapy and chemotherapy, the patient's pain was improved.Referred facial pain is rare and can be explained by the invasion of the tenth nerve by an upper lobe lung tumor. In most cases, the patient presents a right otalgia and pain in the area of V3. The diagnosis can be delayed from 1 month to 4 years after the onset of the pain. Referred facial pain is improved by the treatment of the causal lung cancer.

Published
2005

16. [Image of the month. Lipoma of the trigeminal nerve]

Author

P, Demez, B, Otto, P, Hans, and J D, Born

Subjects
Trigeminal Nerve Diseases, Humans, Cranial Nerve Neoplasms, Female, Lipoma, Trigeminal Neuralgia, Magnetic Resonance Imaging, Aged
Published
2000

18. Treatment of pharyngeal carcinomas by laser endoscopic microsurgery

Author

P. Demez, P. Moreau, and O. Bouchain

Subjects
medicine.medical_specialty, Oncology, business.industry, law, medicine.medical_treatment, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, Radiology, Microsurgery, business, Laser, law.invention
Published
2007

19. Light and electron microscopic immunolocalization of bovine pregnancy-associated glycoprotein in the bovine placentome

Author

A P, Zoli, P, Demez, J F, Beckers, M, Reznik, and A, Beckers

Subjects
Microscopy, Electron, Pregnancy, Placenta, Animals, Pregnancy, Animal, Cattle, Female, Chorionic Villi, Pregnancy Proteins, Immunohistochemistry, Glycoproteins
Abstract

A bovine pregnancy-associated glycoprotein (bPAG) of 67 kDa has previously been isolated from bovine fetal cotyledons. The objective of this study was to determine the cytological localization of that protein in the placentomes and possibly the cells responsible for its production. Highly specific antisera raised against pure bPAG were used to demonstrate the cellular localization of the protein in bovine placentomes by light and electron microscopic techniques. Strong immunostaining was observed exclusively in the cytoplasm of large binucleate cells present predominantly in fetal cotyledonary tissue (villi). Some smaller weakly immunostained cells were also present in caruncular epithelium. By ultrastructural immunogold procedures, the protein was detected only within amorphous cytoplasmic granules. Granules of identical size, but weakly labeled, were found on the maternal side. All cells containing labeled granules were binucleate. These results suggest that bPAG is probably synthesized by trophoblast binucleate cells and stored in granules prior to delivery into the maternal circulation after cell migration.

Published
1992

21. Testing the Validity of Wagner's Law: 1998-2004, The Case of Turkey

Author

Bayrakdar, Seda, Demez, Selim, and Yapar, Mustafa

Abstract

The relationship between public expenditures and GDP is an important issue. The direction of causation of this relationship affects macroeconomic variables. According to Wagner's Law an increase on GDP increases the public expenditures. Unlike the Wagner's Law, Keynes argues that an increase on public expenditures provides growth of GDP. In this study, the direction of relationship between public expenditures and growth of GDP for Turkish economy has been examined. In order to reach an empirical conclusion, the validity of Wagner's Law for Turkey was tested by using econometric models.

Published
2015
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22. Relationship between Real Oil Price and Real Exchange Rate: The Case of Turkey

Author

Doğan, Seyhun, Ustaoğlu, Murat, and Demez, Selim

Abstract

For developing countries like Turkey which lack of sufficient amount of oil and energy resources, real exchange rate and real oil prices are important for sustainable economic growth rate. The academic accounts focusing on the fluctuation in both factors in the oil exporting and developed countries also show that real oil prices are influential in determining the real exchange rates. There are only a few works on the developing countries. In the non-oil exporting-developing countries, real oil price is affected by the fluctuations in the real exchange rate which require changes to the macro-economic policies. This paper investigates the long-run relationship between real oil prices and real exchange rates by using a monthly data from 02:2001 to 07:2011. In the work, cointegration with structural breaks tests by Perron veKejriwal (2009) are used.

Published
2012
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23. Validity of Fisher Effect for Turkish economy: Cointegration Analysis

Author

İncekara, Ahmet, Demez, Selim, and Ustaoğlu, Murat

Abstract

Fisher effect which can be defined as a positive relation between nominal interest rate and inflation rate without any impact upon real interest rates is something that holders of savings and investments, as well as implementers of monetary policy, pay attention to. In this study, the seasonal series between 1989:Q1 and 2011:Q4 are used to test the validity of Fisher Hypothesis for Turkish economy by Johansen cointegration analysis and VAR method. It is concluded that in the long term, Fisher impact is valid for Turkish economy.

Published
2012
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24. Exchange-Rate Volatility's Impact on Turkey's Exports: An Empirical Analyze for 1992-2010

Author

Demez, Selim and Ustaoğlu, Murat

Abstract

Turkey has gone a process of striking economic growth owing to policies of stability pursued in the aftermath of economic crises in 1990s and early 2000s. The Turkish national economy has maintained a 5 pct growth rate on average in the last decade by reliance on export-based development policies implemented since 1980s. The rise in consumption expenditures in domestic markets, as well as the constructions, which have limited impact upon the size of the foreign trade significantly influence the growth rate. The size of foreign trade has grown since the 2000s significantly and reached to 299 billion USD over this period. The increase in the size of foreign trade has positive impact upon exports; the amount of exports has dramatically increased from 25 billion USD to 113 billion USD in 2010 despite global economic crisis. On the other hand, despite the dramatic increase in the amount of exports, Turkey has also relied on imports; the rising amount of imports led to a problem of current account deficit in the economy. The exchange rate volatility is one of the factors that affect exports most. The exchange rate volatility and financial stability can affect positively or negatively the exports of the developing countries in the short or long terms. In this study, the monthly Currency sale rates (DS) and Export (X) series are considered to investigate whether the X and DS series were affected by each other in the turning points detected by Unit root test with one structural break (Zivot-Andrews) and Unit root test with two structural breaks (Lee-Strazicich). The test results reveal that exports are not affected by structural turnings in the sale of currencies; in other words, the results show that export is not sensitive to the structural breaks and changes in currency rates.

Published
2012
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25. Light and Electron Microscopic Immunolocalization of Bovine Pregnancy-Associated Glycoprotein in the Bovine Placentome1

Author

Zoli, Andre P., Demez, Pierre, Beckers, Jean-François, Reznik, Michel, and Beckers, Albert

Abstract

A bovine pregnancy-associated glycoprotein (bPAG) of 67 kDa has previously been isolated from bovine fetal cotyledons. The objective of this study was to determine the cytological localization of that protein in the placentomes and possibly the cells responsible for its production.Highly specific antisera raised against pure bPAG were used to demonstrate the cellular localization of the protein in bovine placentomes by light and electron microscopic techniques. Strong immunostaining was observed exclusively in the cytoplasm of large binucleate cells present predominantly in fetal cotyledonary tissue (villi). Some smaller weakly immunostained cells were also present in caruncular epithelium. By ultrastructural immunogold procedures, the protein was detected only within amorphous cytoplasmic granules. Granules of identical size, but weakly labeled, were found on the maternal side. All cells containing labeled granules were binucleate. These results suggest that bPAG is probably synthesized by trophoblast binucleate cells and stored in granules prior to delivery into the maternal circulation after cell migration.

Published
1992
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27. Long-term quality of life and psycho-social outcomes after oropharyngeal cancer surgery and radial forearm free-flap reconstruction: A GETTEC prospective multicentric study.

Author

Bozec A, Demez P, Gal J, Chamorey E, Louis MY, Blanchard D, De Raucourt D, Merol JC, Brenet E, Dassonville O, Poissonnet G, Santini J, Peyrade F, Benezery K, Lesnik M, Berta E, Ransy P, and Babin E

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Female, Follow-Up Studies, Humans, Male, Middle Aged, Oropharyngeal Neoplasms pathology, Oropharyngeal Neoplasms surgery, Prognosis, Prospective Studies, Surveys and Questionnaires, Survival Rate, Carcinoma, Squamous Cell psychology, Forearm surgery, Oropharyngeal Neoplasms psychology, Quality of Life, Plastic Surgery Procedures methods, Surgical Flaps
Abstract

Objective: To assess long-term quality of life (QoL) and psycho-social outcomes, and to determine their predictive factors after oropharyngeal cancer (OPC) surgery and radial forearm free-flap (RFFF) reconstruction., Methods: Patients who had undergone OPC surgery and RFFF reconstruction who were still alive and disease-free at least 1 year after surgery were enrolled in this prospective multicentric study. Patients completed the European Organization for Research and Treatment of Cancer (EORTC) Core (QLQ-C30) and Head and Neck Cancer (QLQ-H&N35) QoL questionnaires, the Voice Handicap Index (VHI-10) questionnaire and the Hospital Anxiety and Depression Scale (HADS). The level of dysphagia was evaluated using the Dysphagia Handicap Index (DHI) and the Dysphagia Outcomes and Severity Scale (DOSS). Predictive factors of these clinical outcomes were determined in univariate and multivariate analysis., Results: A total of 58 patients were included in this study. Long-term QoL and functioning scales scores were well-preserved (all superior to 70%). Main persistent symptoms were fatigue, reduced sexuality and oral function-related disorders (swallowing, teeth, salivary and mouth-opening problems). HADS anxiety and depression scores were 7.2 and 5.4, respectively. Twenty-one (36%) patients presented an anxiodepressive disorder (HADS global score ≥ 15). Among the 21 patients who were still working before surgery, 11 (52%) had returned to work at the time of our study. The HADS global score (p < 0.001) was the main predictor of QoL, VHI-10 and DOSS scores., Conclusions: Psychological distress is the main determinant of long-term QoL and is therefore of critical importance in the multidisciplinary management of OPC patients., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Published
2018
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28. Weekly cisplatin with radiotherapy for locally advanced head and neck squamous cell carcinoma.

Author

Sautois B, Schroeder H, Martin M, Piret P, Demez P, Bouchain O, Mutijima E, and Moreau P

Subjects
Adult, Aged, Combined Modality Therapy methods, Female, Humans, Male, Middle Aged, Radiotherapy Dosage, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell radiotherapy, Cisplatin administration & dosage, Head and Neck Neoplasms drug therapy, Head and Neck Neoplasms radiotherapy
Abstract

Purpose: Although commonly used for the treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) concomitant radio-chemotherapy (RT-CT) with weekly cisplatin has not been definitely studied. We conducted a single centre retrospective study with the aim to evaluate efficacy and acute toxicity of definitive concomitant RT-CT with 40 mg/m 2 weekly cisplatin in patients with locally advanced HNSCC with a particular emphasis on RT modality (conventional or accelerated) and dose of cisplatin delivered., Methods: One hundred and twelve consecutive patients were included. They were given cisplatin 40 mg/m 2 )week concomitantly with conventionally fractionated (CFRT) (N=33) or accelerated (ART) (N=79) RT., Results: RT was delivered according to the treatment plan in 104 patients and full dose was given to 107 patients. A median cumulative cisplatin dose of 240 mg/m 2 was administered to patients treated with CFRT and of 200 mg/m 2 to those treated with ART. Overall complete response rate was 81.3%. With a median follow up of 38.4 months, median overall survival (OS) was 75 months, not influenced by RT type or cisplatin dose received. The most clinically significant grade 3 or 4 acute toxicities were stomatitis (35.7%), neutropenia (25%), anemia (12.5%) and acute kidney injury (5.4%)., Conclusions: Our study shows that a median cumulative dose of 200 mg/m 2 cisplatin can be safely administered using a weekly regimen to patients treated with concomitant RT (CFRT or ART). Efficacy results and toxicity compare favorably with those described with triweekly cisplatin RT-CT, suggesting that a randomized comparison should be undertaken.

Published
2016

29. Direct and indirect injuries of the pharynx and larynx.

Author

Berget J, Tonglet M, Ransy P, Gillet A, D'Orio V, Moreau P, Ghuysen A, and Demez P

Subjects
Airway Management, Dyspnea etiology, Endoscopy, Humans, Larynx diagnostic imaging, Larynx surgery, Neck anatomy & histology, Pharynx diagnostic imaging, Pharynx surgery, Physical Examination, Wounds, Nonpenetrating complications, Wounds, Nonpenetrating surgery, Wounds, Penetrating complications, Wounds, Penetrating surgery, Larynx injuries, Pharynx injuries, Wounds, Nonpenetrating diagnosis, Wounds, Penetrating diagnosis
Abstract

Direct and indirect injuries of the pharynx and larynx. The neck is characterized by a relatively complex anatomy and a very compact content. It therefore forms an extremely vulnerable part of the human body. Although uncommon, aero-digestive tract injuries caused by trauma present a challenging situation for both the emergency doctor and the head and neck surgeon. Clinical presentations may vary from severe acute distress with immediate life-threatening airway obstruction to apparently more reassuring situations. However, the latter turn out to be frequently misleading, since patients may deteriorate suddenly as the result of unrecognized injuries. In such cases, delayed diagnosis is often associated with increased morbidity and mortality. Due to its role in phonation, breathing and alimentation, injuries to the aero-digestive tract also expose the patient to severe later impairment and a poorer quality of life. Comprehensive airway control remains the highest and often most challenging priority for the emergency physician. Careful clinical examination combined with endoscopy and computed tomography imaging form the key elements in diagnosis and early recognition of patients who may require surgical management.

Published
2016

30. [What is the standard treatment approach for a cervical lymph node metastasis from a squamous cell carcinoma of unknown origin?].

Author

Piret P, Werenne X, Sautois B, Demez P, and Coucke P

Subjects
Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell therapy, Combined Modality Therapy, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms therapy, Humans, Lymphatic Metastasis, Neoplasms, Unknown Primary diagnosis, Neoplasms, Unknown Primary therapy, Positron-Emission Tomography, Prognosis, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms pathology, Neoplasms, Unknown Primary pathology
Abstract

The diagnostic work-up of cervical lymph node metastases from an occult primary tumour in the head and neck region is well established. PET-scan, which was controversial, is nowadays an integral part of it. Common therapeutic strategies include neck dissection followed by extensive irradiation of pharyngeal mucosa and bilateral lymph node areas. Chemotherapy is often added to these treatment modalities, especially if negative prognostic factors are present on the pathological specimen. However, its therapeutic benefit is not yet proven. There are numerous phase II studies available in the literature, sometimes with controversial conclusions. Therefore, as long as there are no data issued from randomized controlled trials, the treatment decisions are copied from the ones which are used when the primary tumour is well identified in the head and neck area.

Published
2014

31. [Aero-digestive tract squamous intra-epithelial neoplasia].

Author

Duquenne S, Saussez S, Demez P, Thiry A, and Delvenne P

Subjects
Carcinoma in Situ classification, Carcinoma in Situ genetics, Carcinoma, Squamous Cell classification, Carcinoma, Squamous Cell genetics, Digestive System Neoplasms classification, Digestive System Neoplasms genetics, Epigenesis, Genetic genetics, Humans, Respiratory Tract Neoplasms classification, Respiratory Tract Neoplasms genetics, Risk Factors, Carcinoma in Situ pathology, Carcinoma, Squamous Cell pathology, Digestive System Neoplasms pathology, Respiratory Tract Neoplasms pathology
Abstract

Aero-digestive tract squamous intra-epithelial neoplasia is a disease whose genetic and epigenetic features lead to clinical signs and well codified histologic features. This publication aims to review the molecular alterations which have been identified in these lesions, to clarify the clinical manifestations and to discuss the proposed histological classification., (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)

Published
2013
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32. [Neoadjuvant chemotherapy in head and neck cancer].

Author

Martin M, Demez P, Moreau P, Devillers D, Piret P, and Sautois B

Subjects
Antineoplastic Agents therapeutic use, Humans, Head and Neck Neoplasms therapy, Neoadjuvant Therapy
Abstract

Head and neck cancer represent 5% of all cancer and is often diagnosed at advanced stage. Treatment requires a multidisciplinary approach and relies on surgery, radiotherapy and/or chemotherapy. In locally advanced disease, chemotherapy has been shown to improve survival, particularly when delivered concomitantly with radiotherapy (6.5% absolute benefit in overall survival. Although induction or neoadjuvant chemotherapy has been much studied, no clear benefit has been identified but for larynx preservation. New chemotherapy regimens with adjonction of taxanes have drawn attention again on induction chemotherapy. Several randomised controlled trials have demonstrated improved response rate, disease free survival, or overall survival when docetaxel is added to cisplatin and 5 FU as induction chemotherapy. A definitive proof of the benefit of the induction approach is still lacking. To date, induction chemotherapy can only be recommended with the aim of preserving laryngeal function. Ongoing trials are expected to validate or rule out the induction strategy as a standard approach in locally advanced head and neck cancer.

Published
2010

33. [Monoclonal antibodies for the treatment of head and neck cancer].

Author

Sautois B, Martin M, Demez P, Piret P, Devillers D, and Moreau P

Subjects
Antibodies, Monoclonal, Humanized, Cetuximab, ErbB Receptors antagonists & inhibitors, Humans, Antibodies, Monoclonal therapeutic use, Antineoplastic Agents therapeutic use, Head and Neck Neoplasms drug therapy
Abstract

Monoclonal antibodies are now part of the armamentarium available for the treatment of head and neck cancer. Cétuximab, a monoclonal antibody targeting EGFR, improves overall survival as compared with radiotherapy alone as radical treatment of locally advanced head and neck cancer. It is now reimbursed in Belgium after multidisciplinary discussion if cisplatin is contra-indicated. In the metastatic setting adding cétuximab to platinum based chemotherapy improves overall survival as compared with chemotherapy alone, a first-time event over a 30-year period, unfortunately not yet accessible to the Belgian patients. Other monoclonal antibodies targeting EGFR or VEGF are also currently under investigation while cétuximab is being explored in the induction, the maintenance or the post-operative radiotherapy settings.

Published
2009

34. [Head and neck tumors: standards of care and new approaches].

Author

Coucke PA, Piret P, Werenne X, Demez P, Sautois B, and Moreau P

Subjects
Combined Modality Therapy, Head and Neck Neoplasms mortality, Humans, Head and Neck Neoplasms therapy
Abstract

We intend to review the general value of radiotherapy in the management of head and neck cancer. Our aim is to define a treatment protocol which is evidence-based and therefore of use in daily clinical practice. There is general agreement on the efficacy of the concomitant schedules combining radiotherapy and chemotherapy, both in the adjuvant setting as well as in the exclusive non-surgical approach. This however does not preclude further research aiming at optimizing the therapeutic index. As far as neoadjuvant chemotherapy is concerned, applied prior to radical local treatment, there are no conclusive data available which allows us to implement this treatment option in routine clinical practice. This approach deserves further investigations and patients should be entered in well designed prospective randomized trials.

Published
2008

35. Facial pain from visceral origin.

Author

Demez P, Goffart Y, and Daele J

Subjects
Aged, Humans, Male, Earache etiology, Facial Pain etiology, Lung Neoplasms complications
Abstract

Introduction: Unilateral facial pain in the trigeminal area is known to be caused by a cancer in the superior lobe of the lung., Case Report: A 65 year old male, heavy smoker, presented a permanent otalgia and a mandibular pain on the left side. These symptoms could not be relieved by common analgesics. All explorations for common etiologies were negative. After an episode of dyspnea, a left lung cancer was discovered. Thanks to radiotherapy and chemotherapy, the patient's pain was improved., Conclusion: Referred facial pain is rare and can be explained by the invasion of the tenth nerve by an upper lobe lung tumor. In most cases, the patient presents a right otalgia and pain in the area of V3. The diagnosis can be delayed from 1 month to 4 years after the onset of the pain. Referred facial pain is improved by the treatment of the causal lung cancer.

Published
2004

36. [Image of the month. Lipoma of the trigeminal nerve].

Author

Demez P, Otto B, Hans P, and Born JD

Subjects
Aged, Cranial Nerve Neoplasms surgery, Female, Humans, Lipoma surgery, Magnetic Resonance Imaging, Trigeminal Nerve Diseases surgery, Trigeminal Neuralgia diagnosis, Trigeminal Neuralgia drug therapy, Cranial Nerve Neoplasms diagnosis, Lipoma diagnosis, Trigeminal Nerve Diseases diagnosis
Published
2000

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