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4 results on '"Panli Han"'

1. A pH‐responsive nanoparticle delivery system containing dihydralazine and doxorubicin‐based prodrug for enhancing antitumor efficacy

Author

Lianxue Zhang, Jianxiang Huang, Damiano Buratto, Panli Han, Zaixing Yang, and Ruhong Zhou

Subjects
antitumor, dihydralazine, drug delivery system, tumor stromal microenvironment, vasculature, Chemistry, QD1-999, Biology (General), QH301-705.5
Abstract

Abstract The efficacy of nanoparticle (NP)‐based drug delivery technology is hampered by aberrant tumor stromal microenvironments (TSMs) that hinder NP transportation. Therefore, the promotion of NP permeation into deep tumor sites via the regulation of tumor microenvironments is of critical importance. Herein, we propose a potential solution using a dihydralazine (HDZ)‐loaded nanoparticle drug delivery system containing a pH‐responsive, cyclic RGD peptide‐modified prodrug based on doxorubicin (cRGD‐Dex‐DOX). With a combined experimental and theoretical approach, we find that the designed NP system can recognize the acid tumor environments and precisely release the encapsulated HDZ into tumor tissues. HDZ can notably downregulate the expression levels of hypoxia‐inducible factor 1α (HIF1α), α‐smooth muscle actin, and fibronectin through the dilation of tumor blood vessels. These changes in the TSMs enhance the enrichment and penetration of NPs and also unexpectedly promote the infiltration of activated T cells into tumors, suggesting that such a system may offer an effective “multifunctional therapy” through both improving the chemotherapeutic effect and enhancing the immune response to tumors. In vivo experiments on 4T1 breast cancer bearing mice indeed validate that this therapy has the most outstanding antitumor effects over all the other tested control regimens, with the lowest side effects as well.

Published
2024
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2. A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ via enhancement of tumor hypoxia levels

Author

Panli Han, Lianxue Zhang, Yaqi Fu, Youyu Fu, Jianxiang Huang, Jinlin He, Peihong Ni, Taimoor Khan, Yang Jiao, Zaixing Yang, and Ruhong Zhou

Subjects
General Materials Science
Abstract

The selective anti-tumor activity and less toxic nature of hypoxia-activated prodrugs including tirapazamine (TPZ) are harbored by hypoxia levels in tumors, the inadequacy of which leads to failure in clinical trials.

Published
2023
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3. A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ

Author

Panli, Han, Lianxue, Zhang, Yaqi, Fu, Youyu, Fu, Jianxiang, Huang, Jinlin, He, Peihong, Ni, Taimoor, Khan, Yang, Jiao, Zaixing, Yang, and Ruhong, Zhou

Abstract

The selective anti-tumor activity and less toxic nature of hypoxia-activated prodrugs including tirapazamine (TPZ) are harbored by hypoxia levels in tumors, the inadequacy of which leads to failure in clinical trials. Thus, the development of effective clinical applications of TPZ requires advanced strategies to intensify hypoxia levels in tumors effectively and safely. In this study, we designed and fabricated a paclitaxel (PTX)-loaded dual-response delivery system with a low dose (

Published
2022

4. Protein corona reduced graphene oxide cytotoxicity by inhibiting endocytosis

Author

Panli Han, Xiuhua Yin, Guangxin Duan, Ling Wen, Ying Yang, and Xuejie Xie

Subjects
chemistry.chemical_classification, Reactive oxygen species, Cell cycle checkpoint, Chemistry, Graphene, media_common.quotation_subject, Protein Corona, Endocytosis, Surfaces, Coatings and Films, law.invention, Colloid and Surface Chemistry, law, Apoptosis, Materials Chemistry, Biophysics, Physical and Theoretical Chemistry, Internalization, Cytotoxicity, Biotechnology, media_common
Abstract

Exposure to graphene is increasing with the extensive application and production of graphene and its derivatives. Graphene may be exposed to a variety of biomicroenvironments, in which the concentrations of biomacromolecules vary. Thus, it is essential to study the toxic behaviors of graphene in different biomicroenvironments. In the present study, we investigated the toxic behaviors caused by graphene oxide (GO) in different biomicroenvironments and its potential mechanisms. Our results revealed that GO injured cells through reactive oxygen species (ROS) induction and induced apoptosis in protein-free microenvironment. However, GO-induced cytotoxicity was weakened remarkably in the presence of protein, which attributed to the reduction of GO internalization and ROS generation. GO induced cell cycle arrest in the G0/G1 phase when the protein concentration is low but had no remarkable cytotoxicity when the protein concentration was high. Our findings provide a basis for the prevention graphene toxicity.

Published
2021
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