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16 results on '"Passi, Samuel F."'

7. Age-Related Macular Degeneration: The Challenges

Author

Rakoczy, Elizabeth P., primary, Ronquillo, Cecinio C., additional, Passi, Samuel F., additional, Ambati, Balamurali K., additional, Nagiel, Aaron, additional, Lanza, Robert, additional, and Schwartz, Steven D., additional

Published
2014
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9. Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

Author

Chan, Aubrey C., Drakos, Stavros G., Ruiz, Oscar E., Smith, Alexandra C.H., Gibson, Christopher C., Ling, Jing, Passi, Samuel F., Stratman, Amber N., Sacharidou, Anastasia, Revelo, M. Patricia, Grossmann, Allie H., Diakos, Nikolaos A., Davis, George E., Metzstein, Mark M., Whitehead, Kevin J., and Li, Dean Y.

Subjects
Gene mutations -- Health aspects -- Research, Brain diseases -- Risk factors -- Genetic aspects -- Research -- Care and treatment, Health care industry
Abstract

Cerebral cavernous malformations (CCMs) are a common type of vascular malformation in the brain that are a major cause of hemorrhagic stroke. This condition has been independently linked to 3 [...]

Published
2011
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10. Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome

Author

Passi, Samuel F, Brooks, Cassandra C, Thompson, Atalie C, and Gupta, Preeya K

Subjects
modulation transfer function, dry eye syndrome, Clinical Ophthalmology, sense organs, objective scatter index, eye diseases, Original Research, neurostimulation
Abstract

Samuel F Passi,1,2 Cassandra C Brooks,1 Atalie C Thompson,1 Preeya K Gupta1 1Department of Ophthalmology, Duke University, Durham, NC, USA; 2Minnesota Eye Consultants, Bloomington, MN, USACorrespondence: Preeya K Gupta Email preeya.gupta@duke.eduPurpose: To evaluate the optical quality and tear film quality in patients with dry eye syndrome (DES) before and after using an intranasal neurostimulation device to stimulate tear production.Methods: Cross-sectional review of 33 eyes in 21 patients with DES who underwent optical quality and tear film analysis as part of their routine dry eye evaluation pre- and post-neurostimulation trial in office. Optical quality was assessed by measuring the objective scattering index (OSI) and modulation transfer function (MTF). The time to blink and mean tear film OSI were used to analyze the tear film.Results: Optical quality after the use of the intranasal neurostimulator improved with an average decrease (improvement) in OSI of 0.30± 0.68 (P=0.015) and an average increase (improvement) in MTF of 2.12± 9.2 (P=0.15). Pre-intranasal neurostimulation OSI had a positive correlation with age (Spearman’s rho 0.60, p < 0.001), while MTF had a negative correlation (Spearman’s rho − 0.38, p = 0.03). Pre-intranasal neurostimulation OSI had a negative correlation with MTF (Spearman’s rho − 0.85, p < 0.001) and a positive correlation with tear film mean OSI (Spearman’s rho 0.85, p < 0.001).Conclusion: The optical quality of patients with DES is improved with the use of intranasal neurostimulation for tear production, and there was a trend towards improved MTF though not statistically significant. Future studies are needed to follow patients longitudinally.Keywords: neurostimulation, objective scatter index, modulation transfer function, dry eye syndrome

Published
2020

13. Regional Structural Uniformity of Left Ventricular Remodeling in Patients with Advanced Non Ischemic Cardiomyopathy

Author

Passi, Samuel F., primary, Diakos, Nikos A., additional, Kfoury, Abdallah G., additional, Selzman, Craig H., additional, Yen, Chi-Gang, additional, Reid, Bruce B., additional, Wever-Pinzon, Omar, additional, Gilbert, Edward M., additional, Budge, Deborah, additional, Nativi-Nicolau, Jose, additional, Hammond, Elizabeth H., additional, High, Craig A., additional, Li, Dean Y., additional, Stehlik, Josef, additional, and Drakos, Stavros G., additional

Published
2013
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14. Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

Author

Chan, Aubrey C., Drakos, Stavros G., Ruiz, Oscar E., Smith, Alexandra C.H., Gibson, Christopher C., Ling, Jing, Passi, Samuel F., Stratman, Amber N., Sacharidou, Anastasia, Revelo, M. Patricia, Grossmann, Allie H., Diakos, Nikolaos A., Davis, George E., Metzstein, Mark M., Whitehead, Kevin J., and Li, Dean Y.

Subjects
Health care industry
Abstract

Original citation: J Clin Invest. 2011;121(5):1871-1881. doi:10.1172/JCI44393. Citation for this corrigendum: J Clin Invest. 2012;122(5):1948. doi:10.1172/JCI63474. The control data provided in Figure 7, E, F, and G, were inadvertently provided [...]

Published
2012

15. Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

Author

London, Nyall R., primary, Zhu, Weiquan, additional, Bozza, Fernando A., additional, Smith, Matthew C. P., additional, Greif, Daniel M., additional, Sorensen, Lise K., additional, Chen, Luming, additional, Kaminoh, Yuuki, additional, Chan, Aubrey C., additional, Passi, Samuel F., additional, Day, Craig W., additional, Barnard, Dale L., additional, Zimmerman, Guy A., additional, Krasnow, Mark A., additional, and Li, Dean Y., additional

Published
2010
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16. Artificial tears potpourri: a literature review.

Author

Moshirfar, Majid, Pierson, Kasey, Hanamaikai, Kamalani, Santiago-Caban, Luis, Muthappan, Valliammai, and Passi, Samuel F.

Subjects
DRY eye syndromes, TEARS (Body fluid), TREATMENT effectiveness, TREATMENT of eye diseases, ETIOLOGY of diseases
Abstract

Numerous brands and types of artificial tears are available on the market for the treatment of dysfunctional tear syndrome. Past literature has focused on comparing the components of these products on patient's clinical improvement. The wide array of products on the market presents challenges to both clinicians and patients when trying to choose between available tear replacement therapies. Different formulations affect patients based on etiology and severity of disease. In order to provide an unbiased comparison between available tear replacement therapies, we conducted a literature review of existing studies and National Institutes of Health clinical trials on commercially available, brand name artificial tears. Outcomes evaluated in each study, as well as the percent of patients showing clinical and symptomatic improvement, were analyzed. Fifty-one studies evaluating different brands of artificial tears, and their efficacy were identified. Out of the 51 studies, 18 were comparison studies testing brand name artificial tears directly against each other. Nearly all formulations of artificial tears provided significant benefit to patients with dysfunctional tear syndrome, but some proved superior to others. From the study data, a recommended treatment flowchart was derived. [ABSTRACT FROM AUTHOR]

Published
2014
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