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233 results on '"Patonay, Tamas"'

11. Synthesis of functionalized para- and meta-terphenyls based on site-selective Suzuki cross-coupling reactions of bis(triflates) of methyl 2,5-dihydroxybenzoate and methyl 2,4-dihydroxybenzoate

Author

Nawaz, Muhammad, Ullah, Ihsan, Abid, Obaid-ur-Rahman, Ali, Asad, Patonay, Tamas, Saghyan, Ashot S., Ghochikan, Tariel V., Villinger, Alexander, and Langer, Peter

Subjects
Structure-activity relationships (Biochemistry) -- Research, Chemistry
Abstract

The palladium(0)-catalyzed Suzuki cross-coupling reaction of the bis(triflates) of methyl 2,5-dihydroxybenzoate and methyl 2,4-dihydroxybenzoate afforded para- and meta-terphenyls, respectively. The reactions proceeded with very good site selectivity in favor of the sterically less hindered carbon atom. Key words: terphenyls, cross-coupling, palladium, site selectivity, Suzuki reaction. La reaction de couplage croise de Susuki des bis(triflates) de methyl 2,5-dihydroxybenzoate et de methyl 2, 4-dihydroxybenzoate catalysee au palladium(O) a donne les para-et meta-terphenyles, respectivement. Les reactions se sont deroulees avec une tres bonne selectivite de site en faveur de l'atome de carbone steriquement le moins encombre. [Traduit par la Redaction] Mots-cles: terphenyles, couplage croise, palladium, selectivite de site, reaction de Suzuki., Introduction Functionalized p-terphenyls occur in a great variety of pharmacologically relevant natural products. Examples include terphenyllin, (1) terprenin, (2) curtisian A, (3) leucomentin- (6,4) thelephorin A, (5) ganbajunin D, (6) [...]

Published
2013
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12. Chemo- and diastereoselectivity in the dimethyldioxirane oxidation of 2,3-dihydro-4H-1-benzothiopyran-4-ones and 4H-1-benzothiopyran-4-ones. Unusual reactivity of 4H-1-benzothiopyran-4-one 1-oxides

Author

Patonay, Tamas, Adam, Waldemar, Levai, Albert, Kover, Peter, Nemeth, Marta, Peters, Eva-Maria, and Peters, Karl

Subjects
Chemistry, Organic -- Research, Oxidation-reduction reaction -- Physiological aspects, Oxides -- Research, Oxygen -- Physiological aspects, Sulfones -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on hiochromanone- and thiochromone-type substrates' dioxirane oxidation. The chemoselectivity and diastereselectivity of oxygen transfer have been investigated.

Published
2001

13. Synthesis and cyclization of 1-(2-hydroxyphenyl)-2-propen-1-one epoxides: 3-hydroxychromanones and -flavanones versus 2-(1-hydroxyalkyl)-3-coumaranones

Author

Patonay, Tamas, Levai, Albert, Nemes, Csaba, Timar, Tibor, Toth, Gabor, and Adam, Waldemar

Subjects
Organic compounds -- Synthesis, Ring formation (Chemistry) -- Research, Epoxy compounds -- Research, Carbonyl compounds -- Research, Biological sciences, Chemistry
Abstract

The cyclization of 2'-hydroxychalcone epoxides was investigated. The results showed that both alpha and beta cyclizations of the epoxides to 2-(alpha-hydroxybenzyl)-3-coumaranone and to trans-3-hydroxyflavanone, occurred under basic conditions. Likewise, extension of the method to the 1-(2-hydroxyphenyl)-2-alken-1-one epoxides obtained via DMD oxidation showed that alpha cyclization takes place with beta-unsubstituted and -monoalkylated alpha,beta-enones.

Published
1996

15. Base-promoted reactions of alpha-azido ketones with aldehydes and ketones: a novel entry to alpha-azido-beta-hydroxy ketones and 2,5-dihydro-5-hydroxyoxazoles

Author

Patonay, Tamas and Hoffman, Robert V.

Subjects
Aldehydes -- Research, Ketones -- Research, Chemical reactions -- Observations, Biological sciences, Chemistry
Abstract

The base-promoted reactions of alpha-azido ketones with aldehydes and ketones create an efficient reaction process for synthesizing either alpha-azido-beta-hydroxy ketones or 2,5-dihydro-5-hydroxyoxazoles. An aldol reaction of an aldehyde and an enolate of the alpha-azidoketone produces alpha-azido-beta-hydroxy ketones. During the electrophilic trapping of an imino anion generated by loss of nitrogen from the alpha-azido ketone enolate, 2,5-dihydro-5-hydroxyoxazoles are prepared.

Published
1995

16. Modification of hydroxybenzopyranoids: facile deoxygenation of 2, 2-dimethyl-7-hydroxy-4-chromanones and a new approach to their novel mercapto analogs

Author

Sebok, Peter, Timar, Tibor, Eszenyi, Tibor, and Patonay, Tamas

Subjects
Organic compounds -- Synthesis, Organosulfur compounds -- Research, Hydrolysis -- Analysis, Biological sciences, Chemistry
Abstract

Existing deoxygenation method helps deoxygenate a series of substituted 2,2-dimethyl-7-hydroxy-4-chromanones through their sulfonate, isourea and thiocarbamate derivatives in excellent yields. These thiocarbamates undergo hydrolysis, generating novel 2, 2-dimethyl-7-mercapto-4-chromanones. Hydrolytic side reactions inhibit the efficiency of deoxygenation of various sulfonates. While the hydrolysis of thiocarbamate derivatives yields the corresponding 2, 2-dimethyl-5-hydroxy-4-chromanone, a similar synthesis is not possible from the isourea derivatives.

Published
1994

17. Dioxirane oxidation of 3-arylideneflavanones: diastereoselective formation of trans,trans spiroepoxides from the E isomers

Author

Nemes, Csaba, Levai, Albert, Patonay, Tamas, Toth, Gabor, Boros, Sandor, Halasz, Judit, Adam, Waldemar, and Golsch, Dieter

Subjects
Ethylene oxide -- Research, Oxo compounds -- Research, Oxidation-reduction reaction -- Analysis, Epoxy compounds -- Analysis, Biological sciences, Chemistry
Abstract

Dioxirane oxidation of (E)-3-arylideneflavanones and (Z)-3-arylideneflavanones with dimethyldioxirane yields the corresponding E isomeric trans,trans spiroepoxides, diastereoselectively. The dioxirane's steric interactions with the E isomers' axial aryl group allows exclusive yield of E isomeric epoxides. The reaction of E and Z isomers with methyl(trifluoromethyl)dioxirane yields E-isomeric epoxides and decomposition products due to O2-atom transfer and radical type oxidation.

Published
1994

30. ChemInform Abstract: Synthesis of Functionalized para- and meta-Terphenyls Based on Site-Selective Suzuki Cross-Coupling Reactions of Bis(triflates) of Methyl 2,5-Dihydroxybenzoate and Methyl 2,4-Dihydroxybenzoate.

Author

Nawaz, Muhammad, primary, Ullah, Ihsan, additional, Abid, Obaid-ur-Rahman, additional, Ali, Asad, additional, Patonay, Tamas, additional, Saghyan, Ashot S., additional, Ghochikan, Tariel V., additional, Villinger, Alexander, additional, and Langer, Peter, additional

Published
2014
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