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The paper presents the results of research on the application of ion-exchange processes for the extraction of iron (II) and copper (II) ions from liquid acid wastes of electroplating production. In the course of experimental studies, it was shown that with an increase in the concentration of sulfuric acid, the total exchangeable dynamic capacity (TEDC) of the cationite significantly decreases both during the sorption of iron ions and during the sorption of copper ions. At the same time, an increase in the iron (II) ions concentration leads to a significant increase in TEDC – even with a sulfuric acid concentration of 8–13 g/dm3, TEDC reached the level of 1.35 g-eq/dm3, which corresponds to the sorption level of neutral dilute solutions. However, it can be seen from the total concentration that the efficiency of sorption of metals from acidic solutions remains quite high and increases with the increase of the initial total content of sorbed ions. The main indicator used when choosing an ion exchange method is the possibility of effective regeneration of the cation exchange material. When using a 5% solution of sulfuric acid already at the specific consumption of the regeneration solution, it was possible to achieve a degree of regeneration at the level of 95–98%, and when using a 10% solution, the degree of regeneration reached 100%. According to the research results, a technological scheme for processing regeneration solutions by precipitation of metals from regeneration solutions into magnetites in a ferritizer reactor was proposed.

The purpose of this work is to assess the risks to the health of the population living in the zone of influence of emissions of pollutants into the atmospheric air from the operating enterprise for the production of carbon electrodes and to generalize the experience of applying the procedure for assessing risks and damage to the health of the population in the system of new monitoring and management mechanisms air quality. The risk assessment of the impact of planned activities on the health of the population from atmospheric air pollution was carried out based on the risk calculations of the devel-opment of non-carcinogenic and carcinogenic effects. During the assessment of the risk to public health from the emissions of the enterprise for the production of carbon electrodes, carbon monoxide was identified as one of the priority pollutants, to reduce the emissions of which it is proposed to use catalytic methods in the furnaces for firing and graphitizing carbon electrodes. Based on the results of the conducted research, it is proposed to introduce technologies that will allow to achieve the maximum permissible emissions of pollutants into the atmosphere during heat treatment.

Under the conditions of chronic obstructive pulmonary disease (COPD), chronic pancreatitis (CP) progresses with the development of exocrine pancreatic insufficiency (EPI), which occurs when the active area of the acinar epithelium decreases as a result of the inflammatory process and fibrosis of the organ. The objective of the study was to study the peculiarities of the processes of the pancreas tissue fibrosis in patients with chronic pancreatitis in case of comorbidity with chronic obstructive pulmonary disease. A prospective cohort study was conducted with the analysis of inpatients’ medical records of 305 patients. The first group of patients consisted of 96 people with an isolated course of CP, the second group consisted of 116 patients with CP with comorbid COPD, the third group consisted of 93 patients with isolated COPD. The comparison group consisted of 30 practically healthy persons. The study also used data from a clinical blood analysis, a biochemical study of the content of markers of the syndrome of deviation of the pancreas enzymes in the blood, the content of elastase-1 in feces, ultrasonographic examination of abdominal organs, changes in the carbohydrate-pro­tein components of the extracellular matrix, the state of collagenolytic activity of the blood plasma. In patients with CP in the exacerbation phase without comorbid pathology, as well as with comorbid COPD and isolated COPD, a significant activation of fibrosing reactions was established: activation of collagen synthesis was registered as an indicator of an increase in the content of protein-bound oxyproline (PBOP) in the blood: in patients of the 1st group – 1.7 times, patients of the 2nd group – 2.1 times and 3rd group – 2.3 times (p

This study investigates methods to improve the rooting efficiency of sweet and sour cherry clonal rootstocks. Propagation with softwood cuttings is one of the effective ways of speeding up the production of high-quality planting material. We evaluated the use of different types of biostimulants for rooting rate, quality, quantity of roots, and growth of softwood cuttings. The study involved propagation of the five most popular rootstocks in Ukraine: Krymsk® 5, Krymsk® 6, Krymsk® 7, Gisela 5, and Colt. Results indicated that softwood cuttings, particularly for Krymsk-type rootstocks, offer a cost-effective propagation method. Rooting efficiency varied from 53.6±5.1% to 65.1±4.4%, and stimulant Zircon at a concentration of 0.5 ml/L was the least effective. Among other stimulants, IBA at 50 mg/L (control) and Zircon at 0.1 ml/L showed the best results. Rootstock Krymsk® 7 had the highest percentage of rooting (90.7±1.3%) and the longest roots (10.3±0.2 cm), while Gisela 5 had the lowest values of the indices (41.5±1.5% rooting and 3.9±0.4 roots per plant). The control (Krymsk® 5) variant showed the highest shoot growth (12.1±0.8 cm). The results show that the rootstock genotype has a decisive influence on the process of rooting and plant growth, rather than the stimulants.

Стаття присвячена аналізу оригінальної концепції довірчої власності - вакфу, спеціального релігійного фонду, створення та функціонування якого регулюється системою норм ісламського права. Активи вакфу формуються завдяки добровільному і зазвичай безповоротному пожертвуванню та спрямовуються на благодійні цілі або цілі, які відповідають ісламському праву. Система вакфів є одним із наріжних каменів ісламської цивілізації. Вакфи як філантропічні установи традиційно відігравали ключову роль у розвитку освіти, науки, охорони здоров’я, юриспруденції. З економічної точки зору вакф можна розглядати як ощадно-інвестиційний механізм, де ресурси не споживаються, а інвестуються в певну діяльність, яка забезпечує дохід. У статті описано модель утворення та функціонування традиційного вакфу: засновник вакфу (вакіф) передає майно спеціальному управителю (мутаваллі) для використання з певною метою на користь визначених бенефіціарів. Проаналізовано основні типи вакфів – благодійний (створений з певною благодійною метою) і сімейний (створений для підтримки сім’ї), а також об’єднаний вакф, який поєднує елементи обох попередніх. Встановлено, що дійсний вакф повинен відповідати п’яти умовам. По-перше, активи, передані до вакфу, мають бути кількісно визначеною власністю, яку можна продати. По-друге, вакф має бути заснований для досягнення благочестивих цілей, що може включати благодійність та підтримку сім’ї. По-третє, активи, передані до вакфу, повинні бути певними та визначеними, що унеможливлює, наприклад, створення вакфу щодо майбутнього об’єкта. По-четверте, вакф повинен бути безумовним, безстроковим і невідчужуваним. По-п’яте, вакіф повинен мати повну правоздатність та дієздатність. У статті також аналізуються доктринальні обмеження для вакфів, зокрема принцип безстроковості існування вакфів та принцип невідчужуваності майна, переданого до вакфу. Сьогодні ці доктринальні обмеження можна обійти завдяки гнучкішому тлумаченню вимог до вакфів деякими школами ісламського права, а також модернізації вакфів шляхом запозичення концепцій з права довірчої власності (трастів).

The article discusses the issue of effective training for crime prevention and detection among Ukrainian police officers. Notably, it requires professional knowledge and skills to be developed at a certain level, which means the need for high professional development and a certain level of self-awareness. Thus, training, retraining, and morale of the future specialist are some of the determinatives for the successful completion of the missions that police encounter. Special features of the professional identity of the future police specialist have not been defined and structured yet. The purpose of this study is to highlight the empirical study on professional self-awareness findings, which cover its content and structure, as well as to analyse the authorial model of content and structural components of professional self-awareness among future police professionals that was developed for studies in higher educational institutions. The study analysed the problem of future police officers' professional identity and devotion to the organisation. The main research methods included the methods of S. Schwartz's theory of basic human values; methods of R. Cattell's 16 personality factor model; methods A. Rean and V. Yakunin's diagnostics of the motives of students' learning in modification of N. Badmaeva; methods of V. Stephenson's "Q-sorting" in diagnosing the main trends of behaviour in a real group and ideas about themselves; A. Zverkova and E. Eidman's test of volitional self-control; R. Schwarzer and M. Jerusalem's scales of general self-efficacy; methods of N. Hall's emotional intelligence diagnostics, analysis of the collected data. As a result, during the period of professional training in accordance with the programme methodology established by the authors, future police officers of the control sample developed such personal and social qualities as work capacity, proactivity, respect for social norms and adherence to them.

This paper sheds light on opinions of reasons of dropout of students enrolled at university as Olympiad winners. This phenomenon is considered using the case of a highly selective university, which has faced a significant increase in the share of enrolled by Olympiads for state-funded places in the past few years. The study is carried out using a qualitative methodology, based on interviews with the organizers of the Olympiad movement and students of the Department of Mathematics and the Department of Computer Science. The individual and institutional reasons for the expulsion of students-winners of the Olympiads are singled out and the recommendations are proposed to reduce the dropout rate.

У статті досліджується природа права людини на податки. Аналізуються особливості та перспективи нормативної фіксації права людини на податки у Конституції України та можливість закріплення конкретних юридичних гарантій суб’єктів даних правовідносин на рівні Основного Закону. Метою дослідження є комплексне дослідження права людини на податки, можливість його юридичної фіксації та аналіз механізмів захисту цього права. Матеріалами дослідження є: 1) нормативно-правове забезпечення щодо регулювання права на податок; 2) праці вітчизняних та зарубіжних авторів, що провадять свої науково-практичні дослідження у сфері податкового права. У процесі дослідження використано наступні методи: філософські, загальнонаукові та спеціальні методи наукового пізнання, зокрема синтезу, аналізу, індукції, дедукції, структурно-функціональний метод та інші. Охарактеризовано поняття та сутність права людини на податки, його значення та основну ідею. Розглянуто податок як явище подвійної природи, що полягає не лише в обов’язку платника податку, але водночас є і його правом як члена громадянського суспільства. Здійснено порівняльний аналіз розуміння правової категорії податку з точки зору як позитивістського, так і людиноцентристського підходу. Розкрито питання обміну між людьми публічними благами. Визначено взаємозв’язок права людини на податки з категорією перерозподільної справедливості. Наведено перелік найбільш поширених публічних потреб людини. Крім того, проаналізовано правову категорію суспільне багатство. Наголошено на важливості й необхідності сумлінної сплати податків в умовах воєнного стану. Окреслено особливості захисту права на податки крізь призму аналізу рішень ЄСПЛ, Суду ЄС, Конституційного Суду України та Верховного Суду. Проаналізовано засновані на позиціях людиноцентризму механізми захисту прав суб’єктів податкових правовідносин. Наголошено на перевагах такого підходу в розрізі дотримання балансу публічного та приватного інтересів платників податків та держави. На основі цих механізмів, окреслено можливість подолання проблеми ухилення від сплати податкових платежів.

In recent years, mean annual air temperature in Ukraine and the world continues to rise steadily. The transition of warm climate crops, including peach, from southern regions to cooler areas latitudes is observed. The article is devoted to the study of drought resistance of new scion-rootstock combinations of peach in modern agroclimatic conditions of the Northern Forest-Steppe zone of Ukraine. Water-physical properties, such as water-holding capacity, moisture deficit and water content in the leaf tissues, were investigated in laboratory conditions. As a result of the experiment on moisture loss resistance, it was established that the level of drought tolerance is high in all combinations. It was determined that ‘Liybymets Ⅱ’, ‘Knyazhe bahatstvo’ and ‘Redhaven’ cultivars are characterized by the lowest indices of water deficit, and ‘Knyazhegradskyi’ by the highest. The highest water content in the leaf tissues was noted in the scion-rootstock combinations ‘Liybymets Ⅱ’ on Pumiselect (76%), ‘Knyazhe bahatstvo’ and ‘Knyazhe zoloto’ on apricot seedlings (84–79%). The tissues of the ‘Redhaven’ cultivar grafted on apricot seedlings were the least hydrated (66%). According to the complex of the determined indicators, Druzhba, Krymsk® 1 and Krymsk® 86 rootstocks are characterized by the lowest adaptive capacity to drought compared to the rest of the rootstocks.

This article presents the results of testing the effect of virus infection on the frost resistance of sour cherry varieties of Ukrainian breeding. ‘Ksenia’ and ‘Boguslavka’ varieties were used. Damage to the tissues of buds and shoots at temperatures of 4 °C, –25 °С, –30 °С was compared on plants infected with viruses (PNRSV in the variety ‘Ksenia’, PDV in the variety ‘Boguslavka’) and healthy plants. The degree of frost damage was classified on a scale from zero (no damage) to five (100% tissue damage). In each variant, 10–34 buds and 3–14 shoots were tested. It was found that the PDV and PNRSV viruses have a negative effect on the frost resistance of bud tissues. At –25°С, the average degree of bud tissue damage reached 3.2 points in the variety ‘Ksenia’ (PNRSV) and 4.1 points in the variety ‘Boguslavka’ (PDV). At –30 °C, the degree of damage to the buds of both varieties was 4.2 points. The same temperatures had a less impact on the tissues of the shoots. The highest damage was recorded in cambium tissues of the infected ‘Boguslavka’ variety at –30 °С, and the lowest was in bark samples of the infected ‘Ksenia’ variety (0.8 points at –25 °С).

Tourism, as an important part of social progress, not only contributes to economic growth but also has the potential to catalyze changes in socio-cultural and ecological dimensions. The relevance of the topic of tourism as a tool for the local economic development of territorial communities of the Carpathian region of Ukraine is due to the following: tourism is a factor in economic growth, which contributes to the creation of new jobs, attracting investments and increasing the level of well-being of the population. Tourism affects the preservation and dissemination of cultural heritage, stimulates interest in preserving natural resources and ecosystems, and promotes understanding, tolerance, and environmental awareness. In challenging conditions such as martial law or other difficult situations, tourism can be a source of profit and a tool for the reconstruction and development of regions in need of support. The purpose of the article is to identify the trend of tourism development in the Carpathian region, its role and significance for local economic development, and on this basis to justify the advantages of their synergistic relationship. The research uses a set of scientific research methods of a general nature (analysis and synthesis, induction and deduction, abstraction, formalization) and a special one (content analysis, comparison, graphic), which made it possible to reveal meaningful interpretations of regularities regarding the understanding of the concepts of «local economic development» and «creative tourism» as well as characterize the synergistic relationship between them. It was established that the Carpathian region has significant tourism potential, and the dynamics of tax revenues from the tourism industry in the Lviv, Ivano- Frankivsk, Zakarpattia, and Chernivtsi regions show a positive result. The Ukrainian and world scientists` works were analyzed regarding the impact of tourism on the local economic development of territorial communities, as a result of which attention was focused on several advantages in the economy, socio-cultural sphere, and ecology.

Sweet cherry (Prunus avium L.) is an economically important and profitable stone fruit species grown in the temperate and subtropical climates, bearing fruits with unique flavour and nutritional benefits. There is also a long tradition of sweet cherry breeding in the Czech Republic. We report here the evaluation of economically important fruit and vegetative characters in 27 sweet cherry cultivars grown in the Research and Breeding Institute of Pomology (RBIP) in the genebank plantation. The cultivars were evaluated phenotypically using standard descriptors for sweet cherries. Established cultivars ‘Burlat’ (early ripening) and ‘Kordia’ (late ripening) were included in the study as commercial standards. The cultivar ‘Früheste der Mark’ was used as the earliest cultivar of the sweet cherry season. The results presented in this study demonstrate the high diversity of the analyzed sweet cherry germplasm. The cultivars ‘Horka’, ‘Justyna’, and ‘Sandra’ stood out in terms of fruit size and taste quality. The evaluated newly bred Czech sweet cherry cultivars are broadly described at the end of the presented paper.

Aim. The goal of work is to study the effects of calix[4]arenes C-715 and C-772 on Ca2+-transport, the electron transport chain activity, and the reactive oxygen species generation in the mitochondria of rat uterine smooth muscle. Methods. Measurement of changes in NADH autofluorescence, as well as the energy-dependent accumulation of Ca2+ and reactive oxygen species generation in the fraction of isolated mitochondria was carried out using the spectrofluorimetry method. The hydrodynamic diameter of mitochondria was measured using the laser correlation spectroscopy method. Results. It was found that calix[4]arenes C-715 and C-772 moderately inhibit both the NADH oxidation and the energy-dependent Ca2+ accumulation by isolated mitochondria. We also showed that the studied calix[4]arenes, depending on concentration and time, reduce the level of reactive oxygen species generation by mitochondria. Additionally, it was revealed that the studied compounds moderately increase mitochondria hydrodynamic diameter depending on concentration. Conclusions. Studied calix[4]arenes slow down the oxidation of NADH in isolated mitochondria, which represents an inhibitory effect on the electron transport chain functioning, in particular its complex I. Since this might lower the electrochemical potential of the inner mitochondrial membrane, we observed reduce of energy-dependent Ca2+ accumulation. Selected compounds decrease the level of reactive oxygen species generation by isolated mitochondria, which could be considered as protective effect on organelles. A moderate increase in mitochondria hydrodynamic diameter suggests that the studied compounds do not cause mitochondrial dysfunction. Researched calix[4]arenes can be used in experimental practice to influence the mitochondrial functional activity.

Introduction The aim of the study was to study the structural and functional state of bone tissue in men with ankylosing spondylitis (AS) and to assess its relationship with the course of the disease. Material and methods A study was conducted with the participation of 105 men with AS aged from 22 to 59 years (average age was 40.7 ±0.8 years) with a duration of the disease of 8.7 ±0.5 years and 29 persons of the control group. Disease activity and the degree of functional limitations were determined by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Activity Score correlated with C-reactive protein (ASDAS-CRP) and the Bath Ankylosing Spondylitis Functional Index (BASFI). Laboratory examination included determination of C-reactive protein (CRP). Bone mineral density (BMD) of the lumbar spine and femoral neck was determined by the method of dual-energy X-ray absorptiometry on the Hologic Discovery Wi device (S/N 87227). Results In men with AS, a decrease in BMD (according to the Z-score and T-score) was found in 41.9%, while the percentage of patients with osteoporosis at the level of the femoral neck and lower back was 16.7%. Development of osteoproliferative changes was observed in 42 (40%) patients. Bone mass loss was associated with high activity of the inflammatory process according to ASDAS, BASDAI ( r = –0.39, –0.65), and CRP ( r = –0.28, –0.38) and low functional capacity according to BASFI ( r = –0.27, –0.59), while syndesmophytosis had a reliable association with the age of the patients, the duration of the disease and low functional capacity. Low-energy fractures occurred in 11.4% of men with AS. The presence of fractures was associated with high disease activity (ASDAS, BASDAI, CRP) and was not related to the age of the patients or duration of the disease. Conclusions A decrease in BMD and the development of fractures were closely associated with high activity of the inflammatory process and low functional capacity, while syndesmophytosis was related to the age of patients and the duration of the disease.

Стаття присвячена удосконаленню стратегічного управління конкурентоспроможністю ТОВ «Сільпо-Фуд» в післявоєнний період на базі аналізу його рівня конкурентоспроможності за рахунок розробки комплексу оптимізаційних заходів. Під час написання статті було розглянуто теоретичні та методичні основи оцінки конкурентоспроможності підприємства. На основі теоретичного матеріалу було досліджено діяльність ТОВ «Сільпо-Фуд», проаналізовано економіко-господарську діяльність ТОВ «Сільпо-Фуд», а також запропоновано напрямки підвищення рівня конкурентоспроможності ТОВ «Сільпо-Фуд». В статті проведено аналіз конкурентного середовища ТОВ «Сільпо-Фуд», в ході якого визначено, що нестабільність економіки, зменшення платоспроможності населення, порушення логістичних ланцюгів, втрата торгових точок через значні руйнування, окупацію територій, удари по енергетичній інфраструктурі країни, небезпека для здоров’я та життя покупців і працівників – усі ці складнощі здійснюють негативний вплив на ринок і по сьогоднішній день. Проведено діагностику управління конкурентоспроможністю на ТОВ «Сільпо-Фуд». На підставі проведено аналізу, зазначимо, що основними складовими управління конкурентоспроможністю ТОВ «Сільпо-Фуд» є: асортиментна політика; політика в сфері якості; робота з постачальниками; система логістики; управління персоналом; цінова політика; сервісна політика; рекламна діяльність. Було визначено наступні ключові принципи оцінювання рівня конкурентоспроможності підприємства: комплексність, системність, об’єктивність, динамічність, безперервність та оптимальність. Проаналізовано основні економічні характеристика галузі роздрібної торгівлі. Для аналізу привабливості продуктового ритейлу використана модель п’яти сил Портера. Розглянуто форми та інтенсивність конкуренції між учасниками галузі. Так конкуренцію у вітчизняному продуктовому ритейлі можна охарактеризувати як інтенсивну. В роботі проведено аналіз сильних та слабких конкурентів за допомогою побудови карт стратегічних груп.

Carbon neutrality is necessary to address the global problem of climate change. The International Energy Agency has recognized coal as the largest source of anthropogenic carbon dioxide emissions. This article analyzes carbon dioxide emissions from coal and carbon dioxide emissions from energy for the major emitters of CO2 emissions. As more than half of the world's Carbon dioxide emissions from coal come from China, the authors have analyzed the extreme situation that could arise in the carbon reduction market if China were to postpone its commitments to reduce coal consumption. The article calculates the time frame required for other coal-consuming countries to phase out coal to compensate for China's annual coal consumption. It demonstrates that without China transitioning from coal consumption to zero-carbon energy sources, other countries will not be able to achieve carbon neutrality by 2050. This proves that for the first time in history, the achievement of the goal set by the global community depends on the actions of a single country. The article outlines the goals set by China in its Nationally Determined Contribution and other government documents to reduce greenhouse gas emissions and achieve carbon neutrality. It also presents China's efforts to implement renewable energy sources, nuclear reactors, and energy storage.

One of the most common eye diseases is a burn injury. Hence, one of the pressing challenges in the field of pharmacy today is the development of new ophthalmic medications, specifically eye drops. Researchers from the Department of Pharmaceutical, Organic, and Bioorganic Chemistry at Zaporizhzhia State Medical and Pharmaceutical University, led by Professor I. A. Mazur, have successfully synthesized a novel compound. This compound is a derivative of 1,2,4-triazole, specifically (S)-2,6-diaminohexanoic acid 3-methyl-1,2,4-triazolyl-5-thioacetate. Notably, this compound demonstrates anti-inflammatory, wound-healing, and reparative activities. The aim of the work is to develop a method of quantitative determination of the active substance in Angiolin eye drops by the method of high-performance liquid chromatography. Materials and methods. The research employed a liquid chromatograph equipped with a UV detector. A column Hypersil ODS C-18 measuring 250 by 4.6 millimeters with a particle size of 5 microns was used. Results. It was determined that the angiolin content in the 1 % eye drops in series 1 falls within the range of 0.985 to 1.010 grams. This indicates that, in terms of the active substance content, the studied series complies with the requirements of the State Pharmacopoeia of Ukraine. Conclusions. As a result of the conducted research, a method for quantitatively determining the active substance in Angiolin eye drops using high-performance liquid chromatography was developed.

Abstract: In the complex treatment of chronic heart failure (CHF) β-adrenoblockers (carvedilol, nebivolol, bisoprolol, metoprolol) are used, which due to their pharmacological properties increase the survival rate of patients, improve cardio- and haemodynamic parameters, metabolism. However, modern realities in medicine require creation of new more effective and safe β-adrenoblockers. In this regard, the potential drug Hypertirl is of interest. The aim was to evaluate the cardioprotective effect of 1-(b-phenylethyl)-4-amino-1,2,4-triazolium bromide (Hypertril) on cardiac electrical activity and autonomic regulation of heart rhythm in a model of CHF in comparison with β-adrenoblockers of different generations (Nebivolol, Carvedilol, Bisoprolol, Metoprolol). Materials and methods: Chronic heart failure was induced by 14-day administration of doxorubicin in a cumulative dose of 15 mg/kg to white mongrel rats weighing 190–220g (total 85). The investigated drugs were administered after doxorubicin course for 30 days: Hypertril at an experimentally substantiated dose of 3.5 mg/kg, Metoprolol succinate 15 mg/kg, Nebivolol 10 mg/kg, Carvedilol 50 mg/kg, Bisoprolol 10 mg/kg. At the end of drug administration under thiopental anaesthesia (40 mg/kg), electrocardiogram (ECG) and autonomic regulation of heart rhythm (ARHR) were analysed using a computer analyser CardioCom-2000plus (KAI-Medica, Ukraine). The results of the study were calculated using a standard statistical package “STATISTICA for Windows 6.0” (StatSoftInc., №AXXR712D833214FAN5), “SPSS 16.0” and “Microsoft Office Excell 2003”. Results and discussion: Hypertril administration resulted in a negative chronotropic effect, normalisation of atrial (P) and ventricular (R) spike amplitude, ST segment inversion below isoline, increased amplitude of ventricular myocardial repolarisation T. Myocardial repolarisation spike were observed, as well as normalised the duration of atrial (P) and ventricular depolarisation phase (QRS complex) to the intact value and restored the duration of electrical diastole (TR interval). Hypertril reduced systolic and diastolic myocardial dysfunction in animals with CHF. Hypertril restored autonomic mechanisms of heart rhythm regulation and balanced activity of sympathetic and parasympathetic parts of autonomic nervous system in the control of cardiac function. Conclusion: The obtained results demonstrated the undoubted advantage of the new original molecule (Hypertril) over basic β-adrenoblockers (Metoprolol, Nebivolol, Carvedilol and Bisoprolol) and experimentally justify further in-depth study to create on its basis a drug for the treatment of CHF.

The results of electrochemical processing of spent acidic, neutral, and alkaline sulfate-chloride-containing regenerative solutions in two- and three-chamber electrolyzers are presented. It has been determined that the highest current efficiency for the products of electrodialysis can be achieved in the presence of hardness ions when processing acidic sulfate-containing solutions using three-chamber electrolyzers. It has been established that during electrodialysis of alkaline solutions after regeneration of anionites containing chloride ions, accumulation of alkali occurs in the cathodic region, and in the anodic region, chloride ions accumulate due to diffusion through the anion exchange membrane during the first stage, followed by preferential oxidation of chloride ions with liberation of free chlorine during the second stage. It has been shown that electrodialysis can effectively solve the problem of comprehensive processing of neutral, alkaline, and acidic regenerative sulfate-chloride-containing solutions, with the production of alkali and acid at concentrations suitable for reuse in regeneration processes.

The article defines the dominant criteria for the functional symbiosis of macro-regional and local-regional systems with a large number of producers of tourism products. A macroeconomic model was developed for calculating the integrated index of international cooperation of the country in the European geoeconomic space of the tourism industry based on standardized variable indicators. A detailed analysis of the development of the tourism industry in Ukraine was carried out, with the determination of the scope of tourist flows in the pre-war period and during the war period. The forecast dynamics of the development of the potential of international cooperation of Ukraine in the geo-economic space of macro-regional systems of Europe are provided.

The article provides a comprehensive economic and legal analysis of the position of national minorities in the labour market. To do this, a comparative analysis of the socio-economic and legal status of national minorities is carried out and an analysis of the situation of national minorities in the labour market is conducted while taking into account real and declarative indicators of the level of employment, which were determined by the author's survey and field experiment. It has been proven that discrimination in the labour market is characteristic of certain, but not all, groups of national minorities, in particular, the Roma. It is believed that the efficiency of the labour market of national minorities also affects tax revenues and the distribution of social costs. Ensuring equal opportunities for these groups contributes to the creation of stable social conditions, reducing the costs of social assistance and increasing the efficiency of social capital. The study of the labour market of national minorities also takes into account the importance of socio-economic stability. The main causes of discrimination of representatives of ethno-national groups in the labour market are singled out, and economic and legal measures to stimulate inclusion in the labour market are defined. Through the author's survey and the field method of fictitious questionnaires, the discrimination of certain groups of national minorities in Ukraine, among them Moldovans and especially the Roma, was proven, and it was proved that the unemployment rate in the region provokes an almost proportional decrease in the number of responses from employers from representatives of national minorities. The field of employment was not a significant factor in indicating certain features of discrimination based on the field of the labour market.

Acoustic metamaterials and phononic crystals represent a promising platform for the development of noise-insulating systems characterized by a low weight and small thickness. Nevertheless, the operational spectral range of these structures is usually quite narrow, limiting their application as substitutions of conventional noise-insulating systems. In this work, the problem is tackled by demonstration of several ways for the improvement of noise-insulating properties of the periodic structures based on coupled Helmholtz resonators. It is shown that tuning of local coupling between the resonators leads to the formation of a broad stopband covering ∼3.5 octaves (200–2100 Hz) in the transmission spectra. This property is linked to band structures of the equivalent infinitely periodic systems and is discussed in terms of bandgap engineering. The local coupling strength is varied via several means, including introduction of chirped structures and lossy resonators with porous inserts. The stopband engineering procedure is supported by genetic algorithm optimization, and the numerical calculations are verified by experimental measurements.

Purpose: the purpose of the article is to conduct an analysis of the peculiarities of the restriction of land rights of foreign natural persons, stateless persons and foreign legal entities under the legislation of Ukraine, as well as to formulate on this basis the definition of the specified term for the improvement of land legal terminology. Method. The methodology includes a comprehensive analysis and generalization of the available scientific and theoretical material, as well as the formulation of relevant conclusions and recommendations. The following methods of scientific knowledge were used during the research: analysis and synthesis, systemic-structural, comparative-legal, and historical-legal methods. Results. In the process of research, the meaning of the term "limitation of rights to land" of foreign individuals and legal entities in Ukraine was determined, which consists in the establishment of certain prohibitions that define the limits of possible behavior and lead to a narrowing of the scope of the land powers of the specified subjects in the process of acquiring and exercising rights by them ownership of land plots and land use rights, which complicates or makes impossible the acquisition or realization of their land rights. The term "restriction of rights to land" should be distinguished from the term "burdening rights to land" of foreign individuals and legal entities in Ukraine, which consists in imposing additional obligations on foreign entities in the process of exercising their rights to land, which complicates their realization land rights. Originality. In the process of the analysis, it was proven that restrictions on the land rights of foreign natural persons, stateless persons and foreign legal entities are established in the same scope and order as for citizens of Ukraine and legal entities of Ukraine. In addition, additional restrictions on land rights of foreign subjects may be established by provisions of the Civil Code of Ukraine, other land laws for reasons of ensuring national security, preserving land as the main national wealth of Ukraine, ensuring priority access to land rights of citizens of Ukraine and legal entities of Ukraine. Practical significance. The results of the study can be used in the research field - for the further development of the problems of legislative regulation of restrictions on the rights to land of foreign natural persons, stateless persons and foreign legal entities under the legislation of Ukraine, as well as in the rule-making work - in the preparation of draft regulations , aimed at improving the legislative regulation of the legal status of foreign individuals, stateless persons and foreign legal entities as subjects of land relations.

Країни ЄС накопичили багатий досвід природокористування. Еволюція екологічної політики ЄС призвела до чіткого підходу до визначення та вирішення екологічних проблем. Застосування екологічних стандартів є запорукою сталого функціонування екосистем у розвинених країнах Європи. Практика показала, що бездумне копіювання досвіду інших країн, без урахування специфіки формування та розвитку екологічного простору України, не може підвищити ефективність використання її наявного потенціалу природних ресурсів і не може забезпечити сталий розвиток нашої території. Безперечно, досягнення високих екологічних стандартів ЄС має стати стратегічним завданням екологічної політики України найближчим часом, але водночас і непростим. Досягнення Європейського співтовариства у сфері охорони навколишнього середовища є результатом тривалого процесу не лише реформ на національному та регіональному рівнях, а й усвідомлення кожним громадянином важливості створення умов для гідного життя не тільки собі, а й майбутнім поколінням. Усі реформи, які здійснюються для впровадження екологічної складової Угоди про асоціацію, мають регіональний (субнаціональний) контекст. Україна обіцяла поступово наблизити своє законодавство до права ЄС, але не змогла цього зробити Впровадження та дотримання законодавства на регіональному рівні, швидше за все, залишиться файлом у шухляді. Органи місцевого самоврядування матимуть регуляторні повноваження після прийняття та прийняття відповідних актів у тій чи іншій сфері. Національна екологічна політика — це діяльність органів державної влади щодо забезпечення кожною конституційного права на безпечне для життя і здоров'я довкілля та відшкодування шкоди, завданої порушенням цього права. Однак підприємства та організації повинні її обов’язково враховувати прі здійсненні своєї діяльності, та навіть на основі її можуть розробити власну екологічну політику в межах власної системи екологічного менеджменту.

This article attempts to contribute to the debate on the reasons for the inability of the US and its allies to prevent Russia from destroying the Euro ‑Atlantic security architecture by a full ‑scale invasion of Ukraine, as well as to the discussion of scenarios to strengthen the Euro-Atlantic community in the frame of preparation for the new post-war political landscape and reality. Based on a critical analysis of existing research, it is argued that despite the diversity of views of scholars and the still unpredictable outcome of the war in Ukraine, today it is possible to formulate some theses on the main directions of the European order transformation. These include enhancing the unity of the collective West, awakening Europe in the security and defense dimensions, strengthening and expanding NATO, increasing the US presence in the European region and ‘the end of the history’ of Russia’s return to the League of Superpowers. At the same time, the following issues remain controversial: the relations between Russian aggression and the US ‑NATO strategy after the Cold War, the prospects of the United States maintaining the leading role in ensuring European security given the war ‑induced increase in Europe’s defence capabilities, and Ukraine’s future European and Euro ‑Atlantic integration.

Вступ. Зменшення мінеральної щільности кісткової тканини (МЩКТ) і виникнення остеопорозу є поши­реним і маловивченим ускладненням анкілозивного спондиліту (АС). Посилений кістковий обмін та висока активність запального процесу мають важливе значення у патофізіології асоційованого з АС остеопорозу, а маркери кісткового ремоделювання є цінними маркерами для виявлення втрати кісткової маси. Мета. З’ясувати особливості стану мінеральної щільности кісткової тканини у чоловіків, хворих на анкі­лозивний спондиліт, на основі визначення частоти й характеру порушень мінеральної щільности кісткової тканини, а також виявлення достовірних чинників порушень. Матеріали й методи. Дослідна група складалася з 83 чоловіків, хворих на АС, контрольна – із 29 здоро­вих осіб. Лабораторне обстеження включало визначення С-реактивного білка (СРБ), маркерів метаболізму кісткової тканини та вітаміну D. МЩКТ вимірювали за допомогою рентгенівської абсорбціометрії. Результати. Серед чоловіків, хворих на АС, остеопороз фіксували у 33,7 %, остеопенічний синдром – у 28,9 %, нормальні показники МЩКТ – у 37,4 %. Мала кісткова маса була тісно зв’язана із сумарними по­казниками активности запального процесу за Ankylosing Spondylitis Disease Activity Score, Bath Ankylosing Spondylitis Disease Activity Index та вмістом СРБ. У чоловіків, хворих на АС, пе-реважають процеси кісткової резорбції над процесами біосинтезу кісткової тканини, на що вказує збереже-на концентрація маркерів синтезу та зростання маркера кісткової резорбції в сироватці крови. Крім цього, втрата кісткової маси тісно зв’язана з дефіцитом вітаміну D. Висновки. У чоловіків, хворих на анкілозивний спондиліт, із високою частотою (62,6 %) виявлено змен­шення мінеральної щільности кісткової тканини, при цьому остеопороз трапляється у кожного третього. Втрата кісткової маси залежить від активности запального процесу, високого показника маркера резорбції кісткової тканини та дефіциту вітаміну D.

Creative industries contribute to the use of the cultural and resource potential of the region (cultural traditions, historical and architectural heritage) and their direction for local economic development. The purpose of the article is to identify the trends in the development of creative industries in Ukraine, their role and significance for the tourism industry, and on this basis to justify the advantages of their synergistic connection to the local economic development of the Mykolaiv region. The research uses a set of scientific research methods of a general (analysis and synthesis, induction and deduction, abstraction, formalization) and special (content analysis, comparison, graphic) nature, which made it possible to reveal meaningful interpretations of regularities regarding the interpretation of the concepts of "creative industries" and "creative tourism", as well as characterize the synergistic relationship between them. It was found that creative industries have a positive impact on the country's economy, in particular, the cultural sector accounts for 3.1% of the global gross domestic product, and cultural and creative industries provide almost 50 million jobs. It was established that Ukraine has a significant potential of creative industries, the value of which in the economy is constantly growing, so the export of creative industries accounts for 30% of the total. It has been established that Ukraine has a significant potential of creative industries, the value of which in the economy is constantly growing, so exports of creative industries account for 30% of the total. The scientific works of Ukrainian scientists, as well as scientists of other countries, on the influence of creative industries on the development of tourism were analyzed, as a result of which attention was focused on a number of advantages that can be combined into three groups: the tourism industry (a new unique tourist experience; expansion of the offer without any what additional investments; high-quality and sustainable tourism with high added value and purchasing power); community and population (diversification of the local economy;creative entrepreneurship; sustainable development of the territory; investment attractiveness; new forms of cooperation; improving the quality of life and well-being; social cohesion; community empowerment); the field of culture (positive influence on the development of cultural infrastructure; preservation and restoration of intangible cultural heritage; cooperation in the cultural sphere; formation of creative communities). It is the search for new and creative ways to develop the tourism sector (opening of domestic destinations, development of new routes and territory development projects) that will contribute to increasing the competitiveness of the tourism industry