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Your search keyword '"Peck, Cheryl L."' showing total 11 results
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11 results on '"Peck, Cheryl L."'

2. Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832

Author

Gopalsamuthiram, Vijayagopal, primary, Ho, Dang Binh, additional, Peck, Cheryl L., additional, Natarajan, Vasudevan, additional, Agrawal, Toolika, additional, Burns, Justina M., additional, Bachert, John, additional, Cook, Daniel W., additional, Stringham, Rodger W., additional, Nelson, Ryan, additional, Ahmad, Saeed, additional, Gupton, B. Frank, additional, Snead, David R., additional, McQuade, D. Tyler, additional, Vaidyanathan, Rajappa, additional, Donsbach, Kai, additional, and Sieber, Joshua D., additional

Published
2022
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3. An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines

Author

Derstine, Brenden P., primary, Tomlin, John W., additional, Peck, Cheryl L., additional, Dietz, Jule-Phillip, additional, Herrera, Brenden T., additional, Cardoso, Flavio S. P., additional, Paymode, Dinesh J., additional, Yue, Andrew C., additional, Arduengo, Anthony J., additional, Opatz, Till, additional, Snead, David R., additional, Stringham, Rodger W., additional, McQuade, D. Tyler, additional, and Gupton, B. Frank, additional

Published
2020
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5. Multi-photon patterning of photoactive o-nitrobenzyl ligands bound to gold surfaces

Author

Chemistry, Physics, Magill, Brenden A., Guo, Xi, Peck, Cheryl L., Reyes, Roberto L., See, Erich M., Santos, Webster L., Robinson, Hans D., Chemistry, Physics, Magill, Brenden A., Guo, Xi, Peck, Cheryl L., Reyes, Roberto L., See, Erich M., Santos, Webster L., and Robinson, Hans D.

Abstract

We quantitatively investigate lithographic patterning of a thiol-anchored self-assembled monolayer (SAM) of photocleavable o-nitrobenzyl ligands on gold through a multi-photon absorption process at 1.7 eV (730 nm wavelength). The photocleaving rate increases faster than the square of the incident light intensity, indicating a process more complex than simple two-photon absorption. We tentatively ascribe this observation to two-photon absorption that triggers the formation of a long-lived intermediate aci-nitro species whose decomposition yield is partially determined either by absorption of additional photons or by a local temperature that is elevated by the incident light. At the highest light intensities, thermal processes compete with photoactivation and lead to damage of the SAM. The threshold is high enough that this destructive process can largely be avoided, even while power densities are kept sufficiently large that complete photoactivation takes place on time scales of tens of seconds to a few minutes. This means that this type of ligand can be activated at visible and near infrared wavelengths where plasmonic resonances can easily be engineered in metal nanostructures, even though their single-photon reactivity at these wavelengths is negligible. This will allow selective functionalization of plasmon hotspots, which in addition to high resolution lithographic applications would be of benefit to applications such as Surface Enhanced Raman Spectroscopy and plasmonic photocatalysis as well as directed bottom-up nanoassembly.

Published
2019

11. Asymmetric Conjugate Addition of Alkylzirconocenes to Cyclopent-4-ene-1,3-dione Monoacetals.

Author

Peck, Cheryl L., Calderone, Joseph A., and Santos, Webster L.

Subjects
*COPPER catalysts, *WATER chemistry, *CHEMOSELECTIVITY, *UNSATURATED compounds, *CHEMICAL synthesis, *ESTERS
Abstract

Copper-catalyzed asymmetric conjugate additions are powerful reactions that allow the formation of single-enantiomer building blocks in a few steps. However, highly enantioselective conjugate addition to five-membered-ring substrates is more challenging and is often neglected. Here, we report catalytic asymmetric 1,4-addition of alkylzirconocenes, formed in situ from readily available alkenes, to cyclopent- 4-ene-1,3-dione monoacetals. Good to high enantioselectivities are observed and the procedure tolerates various functional groups. [ABSTRACT FROM AUTHOR]

Published
2015
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