106 results on '"Pegreffi, F."'
Search Results
2. Le protest d’anca non cementate: trattamente delle fratture di collo di femore nel paziente anziano osteoporotico
- Author
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Moroni, A., Pegreffi, F., Lio, V., Giannini, S., De Nicola, U., editor, and Marinoni, E. C.
- Published
- 2006
- Full Text
- View/download PDF
3. Measuring wrist and hand function: Common scales and checklists
- Author
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Hoang-Kim, A., Pegreffi, F., Moroni, A., and Ladd, A.
- Published
- 2011
- Full Text
- View/download PDF
4. REVERSE SHOULDER PROSTHESIS: THE SALVAGE OPTION AFTER PROXIMAL HUMERAL FRACTURES TREATMEN FAILURE
- Author
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Porcellini, G., Campi, F., Lollino, N., Paladini, P., and Pegreffi, F.
- Published
- 2010
5. Comparing Dynamic Hip Screw to External Fixation for Treatment of Osteoporotic Pertrochanteric Fractures: A Prospective Randomized Study
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Moroni, A., primary, Faldini, C., additional, Pegreffi, F., additional, Hoang-Kim, A., additional, Vannini, F., additional, and Giannini, S., additional
- Published
- 2005
- Full Text
- View/download PDF
6. Real Time Kinematic and Electromyographic Analysis: a Feasible Methodology for Assessing Comfort Perception
- Author
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Pegreffi, F., Muraccini, M., Berardi, A., Varini, A., Vergnano, A., Leali, F., and Mantovani, M.
- Published
- 2019
7. Automated ribotyping to distinguish the differentnonSau/nonSep staphylococcal emerging pathogens in orthopedic implant infections
- Author
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CAMPOCCIA, D., BALDASSARRI, L., AN, Y. H., KANG, Q. K., PIRINI, V., GAMBERINI, S., PEGREFFI, F., MONTANARO, L., and ARCIOLA, C. R.
- Published
- 2006
8. Prevalence and antibiotic resistance of 15 minor staphylococcal species colonizing orthopedic implants
- Author
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ARCIOLA, C. R., CAMPOCCIA, D., AN, Y. H., BALDASSARRI, L., PIRINI, V., DONATI, M. E., PEGREFFI, F., and MONTANARO, L.
- Published
- 2006
9. Comparing Dynamic Hip Screw to External Fixation for Treatment of Osteoporotic Pertrochanteric Fractures: A Prospective Randomized Study
- Author
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MORONI , ANTONIO, Faldini C., Pegreffi F., Hoang Kim A., Vannini F., Giannini S., Moroni, Antonio, Faldini, C., Pegreffi, F., Hoang Kim, A., Vannini, F., and Giannini, S.
- Published
- 2005
10. Prevalence of shoulder discomfort in paraplegic subjects
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Pellegrini, A., Pegreffi, F., Paolo Paladini, Verdano, M. A., Ceccarelli, F., and Porcellini, G.
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Adult ,Male ,Paraplegia ,Lumbar Vertebrae ,Age Factors ,Middle Aged ,Thoracic Vertebrae ,Cohort Studies ,Italy ,Wheelchairs ,Risk Factors ,Shoulder Pain ,Prevalence ,Humans ,Aged ,Female ,Spinal Cord Injuries - Abstract
The annual incidence of acute spinal cord injury, as reported in the National Spinal Cord Injury Statistical Center, was estimated to be approximately 40 cases per million, or approximately 11.000 new cases in the United States each year (1). In subjects with spinal cord injury, overstress of the upper extremities occurs not only during daily life activities, but also utilizing wheelchair. The aim of this study is to determine the prevalence of shoulder discomfort in subjects affected by paraplegia living in our country area and evaluate the associated risk factors negatively affecting the shoulder function.A computerized database search for paraplegic patients was performed at the Department of Orthopedic Surgery, Trauma Surgery and Rehabilitation Medicine. Among the 54 selected paraplegic patients, 47 accepted to participate at the study. Once the patients were contacted, the medical records were reviewed to obtain information regarding shoulder, elbow and spine region pain and discomfort.The 60% of all the patients who answered to the questionnaire complain shoulder pain, 90% bilaterally, and the 30% referred elbow pain, 20% bilaterally. 77% complains back pain, involving particularly lumbar region. Only 2% of this population undergoes a shoulder surgery treatment for cuff tear and shoulder disability.The present study is the first in our country that gives an overview of prevalence of upper limb discomfort in paraplegic patients. We have shown the interplay between shoulder elbow and spine with pain, age of patients and type of wheel chair utilized. The previous factors can be corrected and upper limb discomfort relieved.
- Published
- 2012
11. DHS vs. external fixation in patients with pertrochanteric fractures: a prospective clinical study
- Author
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Moroni, A., Faldini, C., Pegreffi, F., Frizziero, Antonio, Hoang Kim, A., and Giannini, S.
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fracture - Published
- 2005
12. Are all hip fractures in elderly patients osteoporotic?
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Hoang kim, A., Vannini, F., Frizziero, Antonio, Cadossi, M., Moroni, A., Pegreffi, F., Gnudi, S., A., HOANG KIM, F., Vannini, A., Frizziero, M., Cadossi, Moroni, Antonio, F., Pegreffi, S., Gnudi, A. Hoang Kim, F. Vannini, A. Frizziero, M. Cadossi, A. Moroni, F. Pegreffi, and S. Gnudi
- Published
- 2004
13. Innovative Methods of Rapid Bacterial Quantification and Applicability in Diagnostics and in Implant Materials Assessment
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Campoccia, D., primary, Speziale, P., additional, An, Y.H., additional, Del Pozo, J.L., additional, Ceresa, L., additional, Pegreffi, F., additional, Montanaro, L., additional, and Arciola, C.R., additional
- Published
- 2007
- Full Text
- View/download PDF
14. Une amélioration de la tenue de fiches revêtues d’hydroxyapatite constatée à l’occasion d’une competition vis plaque/fixateur pour fracture trochantérienne
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Moroni, A., primary, Faldini, C., additional, Pegreffi, F., additional, Hoang-Kim, A., additional, Vannini, F., additional, and Giannini, S., additional
- Published
- 2006
- Full Text
- View/download PDF
15. Automated Ribotyping to Distinguish the Different nonSau/ nonSep Staphylococcal Emerging Pathogens in Orthopedic Implant Infections
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Campoccia, D., primary, Baldassarri, L., additional, An, Y.H., additional, Kang, Q.K., additional, Pirini, V., additional, Gamberini, S., additional, Pegreffi, F., additional, Montanaro, L., additional, and Arciola, C.R., additional
- Published
- 2006
- Full Text
- View/download PDF
16. External Fixation of Pertrochanteric Fractures
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Moroni, A., primary, Faldini, C., additional, Pegreffi, F., additional, Cadossi, M., additional, Hoang-Kim, A., additional, and Giannini, S., additional
- Published
- 2005
- Full Text
- View/download PDF
17. Cast vs External Fixation: A Comparative Study in Elderly Osteoporotic Distal Radial Fracture Patients
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Moroni, A., primary, Vannini, F., additional, Faldini, C., additional, Pegreffi, F., additional, and Giannini, S., additional
- Published
- 2004
- Full Text
- View/download PDF
18. Biomechanical Analysis of Hydroxyapatite-Coated External Fixation Pins Removed from Osteoporotic Trochanteric Fracture Patients
- Author
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Pegreffi, F., primary, Romagnoli, M., additional, Moroni, A., additional, and Giannini, S., additional
- Published
- 2003
- Full Text
- View/download PDF
19. Hydroxyapatite-Coated Screws Prevent Lag Screw Cut-Out in Trochanteric Fractures Fixed with DHS: A Prospective Randomized Study
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Moroni, A., primary, Faldini, C., additional, Pegreffi, F., additional, and Giannini, S., additional
- Published
- 2003
- Full Text
- View/download PDF
20. The Effect of Hydroxyapatite on Bone Ingrowth into Porous-Coated Titanium Implants
- Author
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Moroni, A., primary, Faldini, C., additional, Pegreffi, F., additional, and Giannini, S., additional
- Published
- 2002
- Full Text
- View/download PDF
21. Panton-Valentine leukocidin gene detected in Staphylococcus aureus strain isolated from a knee arthroprosthesis infection.
- Author
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Montanaro L, Baldassarri L, Corazzari T, Creti R, Ravaioli S, Cangini I, Pirini V, Maso A, Donati ME, Pegreffi F, Visai L, Campoccia D, Speziale P, Arciola CR, Montanaro, Lucio, Baldassarri, Lucilla, Corazzari, Tolmino, Creti, Roberta, Ravaioli, Stefano, and Cangini, Ilaria
- Published
- 2009
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22. Fixation of HA-coated unicortical locking screws in a sheep gap model: a comparative biomechanical study.
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Moroni A, Pegreffi F, Hoang-Kim A, Tesei F, Giannini S, and Wippermann B
- Published
- 2008
- Full Text
- View/download PDF
23. Alendronate improves screw fixation in osteoporotic bone.
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Moroni A, Faldini C, Hoang-Kim A, Pegreffi F, Giannini S, Moroni, Antonio, Faldini, Cesare, Hoang-Kim, Amy, Pegreffi, Francesco, and Giannini, Sandro
- Abstract
Background: Animal studies have demonstrated the efficacy of the use of bisphosphonates to enhance screw fixation in bone. In this prospective, randomized study of pertrochanteric fractures treated with external fixation, we tested whether systemic administration of bisphosphonates would improve the fixation of hydroxyapatite-coated screws implanted in osteoporotic bone.Methods: Sixteen consecutive patients with a pertrochanteric fracture were selected. Inclusion criteria were female gender, an age of at least sixty-five years, and a bone mineral density T-score of less than -2.5 standard deviations. Exclusion criteria included bisphosphonate treatment during the two-year period prior to the fracture. Fractures were fixed with a pertrochanteric fixator and four hydroxyapatite-coated pins. Two pins were implanted in the femoral head (pin positions 1 and 2), and two were placed in the femoral diaphysis (pin positions 3 and 4). The patients were randomized either to therapy with alendronate for a three-month postoperative period (Group A) or to no therapy (Group B). The Group-A patients received an oral dose of 70 mg of alendronate per week. The fixators were removed after three months.Results: All of the fractures healed, and no loss of reduction, nonunion, or delayed union was observed. The combined mean extraction torque (and standard deviation) of the pins implanted at positions 1 and 2 (cancellous bone) was 2558 +/- 1103 N/mm in Group A and 1171 +/- 480 N/mm in Group B (p < 0.0005). The combined mean extraction torque of the pins implanted at positions 3 and 4 (cortical bone) was 4327 +/- 1720 N/mm in Group A and 4075 +/- 1022 N/mm in Group B.Conclusions: These data show that weekly systemic administration of alendronate improves pin fixation in cancellous bone in elderly female patients with osteoporosis. We observed a twofold increase in extraction torque with the pins implanted in cancellous bone. These results support the use of alendronate in the treatment of osteoporotic pertrochanteric fractures to improve screw fixation in the femoral head. [ABSTRACT FROM AUTHOR]- Published
- 2007
24. Automated ribotyping to distinguish the different non Sau/ non Sep staphylococcal emerging pathogens in orthopedic implant infections.
- Author
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Campoccia, D, Baldassarri, L, An, Y H, Kang, Q K, Pirini, V, Gamberini, S, Pegreffi, F, Montanaro, L, and Arciola, C R
- Published
- 2006
- Full Text
- View/download PDF
25. Dynamic hip screw compared with external fixation for treatment of osteoporotic pertrochanteric fractures. A prospective, randomized study.
- Author
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Moroni A, Faldini C, Pegreffi F, Hoang-Kim A, Vannini F, Giannini S, Moroni, Antonio, Faldini, Cesare, Pegreffi, Francesco, Hoang-Kim, Amy, Vannini, Francesca, and Giannini, Sandro
- Abstract
Background: Although the use of a sliding hip screw is considered to be the preferred treatment for pertrochanteric femoral fractures, we theorized that external fixation could produce clinical outcomes equal to, if not better than, the outcomes obtained with conventional treatment. Furthermore, because external fixation is minimally invasive, we expected a lower rate of morbidity and a reduced need for blood transfusions. Therefore, we compared the two treatments in a clinical trial of elderly patients with pertrochanteric fracture.Methods: Forty consecutive elderly female patients who had a pertrochanteric fracture were randomized to be treated with either fixation with a 135 degrees four-hole sliding hip screw (Group A) or an external fixation device with hydroxyapatite-coated pins (Group B). The inclusion criteria were female gender, an age of at least sixty-five years, an AO/OTA type-A1 or A2 fracture, and a bone mineral density T-score of less than -2.5. There were no differences in patient age, fracture type, bone mineral density, comorbidities, length of hospital stay, or quality of reduction between the two groups.Results: The average intraoperative time (and standard deviation) was 64 +/- 6 minutes in Group A and 34 +/- 5 minutes in Group B (p < 0.005). The average number of units of blood transfused postoperatively was 2.0 +/- 0.1 in Group A and none in Group B (p < 0.0001). Group B had less pain five days postoperatively (p < 0.05). Varus collapse of the fracture at six months averaged 6 degrees +/- 8 degrees in Group A and 2 degrees 1 degrees in Group B (p < 0.002). No pin-track infections occurred in Group B. The average Harris hip score at six months was 62 +/- 19 points in Group A and 63 +/- 17 points in Group B.Conclusions: This study showed that external fixation with hydroxyapatite-coated pins is an effective treatment for this fracture in this patient population. The operative time is brief, the blood loss is minimal, the fixation is adequate, and the reduction is maintained over time. [ABSTRACT FROM AUTHOR]- Published
- 2005
26. Osteoporotic pertrochanteric fractures can be successfully treated with external fixation.
- Author
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Moroni A, Faldini C, Pegreffi F, Hoang-Kim A, Giannini S, Moroni, Antonio, Faldini, Cesare, Pegreffi, Francesco, Hoang-Kim, Amy, and Giannini, Sandro
- Published
- 2005
27. Automated ribotyping to distinguish the different nonSau/nonSep staphylococcal emerging pathogens in orthopedic implant infections
- Author
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Davide Campoccia, Baldassarri, L., An, Y. H., Kang, Q. K., Pirini, V., Gamberini, S., Pegreffi, F., Montanaro, L., and Arciola, C. R.
28. Osteoporotic pertrochanteric fractures can be successfully treated with external fixation.
- Author
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Sarda PK, Moroni A, Faldini C, Pegreffi F, Koang-Kim A, and Sarda, Praveen K
- Published
- 2006
29. Measuring wrist and hand function: common scales and checklists
- Author
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Antonio Moroni, Amy L. Ladd, Francesco Pegreffi, Amy Hoang-Kim, Hoang Kim, A, Pegreffi, F, Moroni, Antonio, Ladd, A., Hoang-Kim A, Pegreffi F, Moroni A, and Ladd A
- Subjects
Male ,musculoskeletal diseases ,medicine.medical_specialty ,Psychometrics ,joint function ,Wrist ,Physical medicine and rehabilitation ,Surveys and Questionnaires ,Outcome Assessment, Health Care ,Dash ,medicine ,Humans ,Carpal tunnel ,Musculoskeletal Diseases ,Carpal tunnel syndrome ,General Environmental Science ,Hand injury ,business.industry ,CTQ tree ,Hand Injuries ,Construct validity ,Recovery of Function ,Wrist Injuries ,medicine.disease ,fracture healing ,medicine.anatomical_structure ,Quality of Life ,Physical therapy ,General Earth and Planetary Sciences ,Female ,business - Abstract
NTRODUCTION: A hand and wrist disorder affects a patient's overall well-being and health-status. One concept serves as the foundation for all further consideration: in order to have confidence in your results when assessing patients with wrist and hand limitations, the clinician and researcher must choose standardised patient-oriented instruments that address the primary aims of the study. In this paper, we assess the quality of reviews published on patient oriented instruments in current use for assessing function of the hand and wrist joint. We highlight features of commonly used scales that improve readers' confidence in the choice and application of these outcome instruments. METHODS: A literature search (1950-January 2010) was performed using the MESH terms: hand (strength, injuries, joints) and wrist (injuries, joint) combined with outcome and process assessment (questionnaires, outcome assessment, health status indicators, quality of life). Titles and abstracts (n=341) were screened by two reviewers independently. The GRADE approach was used to assess the quality of ten reviews and the inclusion of clinimetric properties were assessed using the COSMIN checklist. RESULTS: We included three systematic reviews rated moderate to high (2 hand injury instrument reviews and 1 wrist fracture outcome review). Recommendations of use and an overview are provided for the disability of the arm, shoulder and hand questionnaire (DASH), QuickDASH, the Michigan hand questionnaire (MHQ), the patient-rated wrist hand evaluation outcome questionnaire (PRWHE) and the carpal tunnel questionnaire (CTQ) scales with established measurement properties. CONCLUSIONS: The DASH, a region-specific 30-item questionnaire is the most widely tested instrument in patients with wrist and hand injuries. The MHQ can provide good value to patients with hand injuries. Although, the CTQ is the most sensitive to clinical change, the DASH and MHQ have shown to be sufficiently responsive to outcome studies of carpal tunnel syndrome. The PRWHE has a good construct validity and responsiveness, which is only slightly better than the DASH to assess patients with wrist injuries. As the quality of patient-oriented validation continues to increase then the instruments can be selected more carefully. We will then be able to see that the future orthopaedic care of patients with hand and wrist injuries may also improve. Introduction A hand and wrist disorder affects a patient's overall well-being and health-status. One concept serves as the foundation for all further consideration: in order to have confidence in your results when assessing patients with wrist and hand limitations, the clinician and researcher must choose standardised patient-oriented instruments that address the primary aims of the study. In this paper, we assess the quality of reviews published on patient oriented instruments in current use for assessing function of the hand and wrist joint. We highlight features of commonly used scales that improve readers’ confidence in the choice and application of these outcome instruments. Methods A literature search (1950–January 2010) was performed using the MESH terms: hand (strength, injuries, joints) and wrist (injuries, joint) combined with outcome and process assessment (questionnaires, outcome assessment, health status indicators, quality of life). Titles and abstracts (n = 341) were screened by two reviewers independently. The GRADE approach was used to assess the quality of ten reviews and the inclusion of clinimetric properties were assessed using the COSMIN checklist. Results We included three systematic reviews rated moderate to high (2 hand injury instrument reviews and 1 wrist fracture outcome review). Recommendations of use and an overview are provided for the disability of the arm, shoulder and hand questionnaire (DASH), QuickDASH, the Michigan hand questionnaire (MHQ), the patient-rated wrist hand evaluation outcome questionnaire (PRWHE) and the carpal tunnel questionnaire (CTQ) scales with established measurement properties. Conclusions The DASH, a region-specific 30-item questionnaire is the most widely tested instrument in patients with wrist and hand injuries. The MHQ can provide good value to patients with hand injuries. Although, the CTQ is the most sensitive to clinical change, the DASH and MHQ have shown to be sufficiently responsive to outcome studies of carpal tunnel syndrome. The PRWHE has a good construct validity and responsiveness, which is only slightly better than the DASH to assess patients with wrist injuries. As the quality of patient-oriented validation continues to increase then the instruments can be selected more carefully. We will then be able to see that the future orthopaedic care of patients with hand and wrist injuries may also improve.
- Published
- 2011
30. Alendronate improves screw fixation in osteoporotic bone
- Author
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Amy Hoang-Kim, Francesco Pegreffi, Sandro Giannini, Cesare Faldini, Antonio Moroni, A. Moroni, Faldini C, Hoang-Kim A, Pegreffi F, Giannini S., Moroni, Antonio, Faldini, C, Hoang Kim, A, Pegreffi, F, and Giannini, S.
- Subjects
medicine.medical_specialty ,Bone density ,medicine.medical_treatment ,Bone Screws ,Osteoporosis ,Dentistry ,Fracture Fixation, Internal ,Fixation (surgical) ,External fixation ,Bone Density ,Fracture fixation ,medicine ,Humans ,Femur ,Orthopedics and Sports Medicine ,Aged ,Aged, 80 and over ,Alendronate ,Bone Density Conservation Agents ,Hip Fractures ,business.industry ,Alendronic acid ,General Medicine ,medicine.disease ,Combined Modality Therapy ,Surgery ,medicine.anatomical_structure ,Female ,Cortical bone ,business ,medicine.drug - Abstract
Animal studies have demonstrated the efficacy of the use of bisphosphonates to enhance screw fixation in bone. In this prospective, randomized study of pertrochanteric fractures treated with external fixation, we tested whether systemic administration of bisphosphonates would improve the fixation of hydroxyapatite-coated screws implanted in osteoporotic bone.Sixteen consecutive patients with a pertrochanteric fracture were selected. Inclusion criteria were female gender, an age of at least sixty-five years, and a bone mineral density T-score of less than -2.5 standard deviations. Exclusion criteria included bisphosphonate treatment during the two-year period prior to the fracture. Fractures were fixed with a pertrochanteric fixator and four hydroxyapatite-coated pins. Two pins were implanted in the femoral head (pin positions 1 and 2), and two were placed in the femoral diaphysis (pin positions 3 and 4). The patients were randomized either to therapy with alendronate for a three-month postoperative period (Group A) or to no therapy (Group B). The Group-A patients received an oral dose of 70 mg of alendronate per week. The fixators were removed after three months.All of the fractures healed, and no loss of reduction, nonunion, or delayed union was observed. The combined mean extraction torque (and standard deviation) of the pins implanted at positions 1 and 2 (cancellous bone) was 2558 +/- 1103 N/mm in Group A and 1171 +/- 480 N/mm in Group B (p0.0005). The combined mean extraction torque of the pins implanted at positions 3 and 4 (cortical bone) was 4327 +/- 1720 N/mm in Group A and 4075 +/- 1022 N/mm in Group B.These data show that weekly systemic administration of alendronate improves pin fixation in cancellous bone in elderly female patients with osteoporosis. We observed a twofold increase in extraction torque with the pins implanted in cancellous bone. These results support the use of alendronate in the treatment of osteoporotic pertrochanteric fractures to improve screw fixation in the femoral head.
- Published
- 2007
31. Hydroxyapatite-coated external fixation pins
- Author
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Francesco Pegreffi, Valentino Lio, Antonio Moroni, Sandro Giannini, Matteo Cadossi, Amy Hoang-Kim, Moroni, Antonio, Pegreffi, F, Cadossi, M, Hoang Kim, A, Lio, V, Giannini, S., Moroni A., Pegreffi F., Cadossi M., Hoang-Kim A., Lio V., and Giannini S.
- Subjects
Insertion torque ,Materials science ,External Fixators ,medicine.medical_treatment ,Medial side ,Extraction (chemistry) ,Biomedical Engineering ,General Medicine ,Bone Nails ,urologic and male genital diseases ,Prosthesis Failure ,Clinical study ,Fixation (surgical) ,External fixation ,Durapatite ,Coated Materials, Biocompatible ,Fracture Fixation ,medicine ,Animals ,Humans ,Surgery ,Animal study ,Biomedical engineering - Abstract
The aim of this review is to report on studies of hydroxyapatite-coated external fixation pins as a solution to enhance pin fixation. In a highly loaded animal study, three tapered pin types were compared: Type A uncoated, Type B coated with hydroxyapatite and Type C coated with titanium. There was a 13-fold increase in the extraction torque of Type B pins compared with Type A, and a twofold increase compared with Type C pins. Extraction torque was significantly lower compared with the corresponding insertion torque in both Types A (p0.001) and C (p = 0.003). Conversely, with the hydroxyapatite-coated pins there was no difference between extraction and insertion torque. In a clinical study of 76 external fixation pins in 19 patients treated with hemicallotasis for osteoarthritis on the medial side of the knee, pin insertion and extraction torque forces were measured. The patients were randomized to be treated with either standard tapered pins or tapered pins coated with hydroxyapatite. Extraction torque of the hydroxyapatite-coated pins was higher than the extraction torque of the standard pins in both cancellous and cortical bone (p0.005). In a prospective, randomized clinical study of osteoporotic wrist fractures, extraction torque of the coated pins was higher than with standard pins (p0.0001). These studies demonstrate that with the use of hydroxyapatite-coated pins, no deterioration of pin fixation occurs, and that there is no significant pin loosening and infection, regardless of bone type and loading conditions.
- Published
- 2005
32. HA-coated screws decrease the incidence of fixation failure in osteoporotic trochanteric fractures
- Author
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Sandro Giannini, Francesco Pegreffi, Antonio Moroni, Cesare Faldini, MORONI A., FALDINI C, PEGREFFI F, GIANNINI S., Moroni, Antonio, Faldini, C, Pegreffi, F, and Giannini, S.
- Subjects
musculoskeletal diseases ,Radiography ,Osteoporosis ,Bone Screws ,Bone healing ,Statistics, Nonparametric ,Fixation (surgical) ,Fracture Fixation, Internal ,Postoperative Complications ,Coated Materials, Biocompatible ,Fracture fixation ,medicine ,Humans ,Orthopedics and Sports Medicine ,Femoral neck ,Aged ,Orthodontics ,Aged, 80 and over ,Fracture Healing ,Dynamic hip screw ,Analysis of Variance ,Chi-Square Distribution ,business.industry ,Hip Fractures ,General Medicine ,equipment and supplies ,musculoskeletal system ,medicine.disease ,surgical procedures, operative ,medicine.anatomical_structure ,Durapatite ,Treatment Outcome ,Harris Hip Score ,Surgery ,Female ,business - Abstract
This study was done to determine if elderly patients with trochanteric fractures and with osteoporosis could benefit from treatment with a dynamic hip screw fixed with HA-coated AO/ASIF screws. One hundred twenty patients with AO, A1, or A2 trochanteric fractures were selected. Patients were divided into two groups and randomized to receive a 135 degree-four-hole dynamic hip screw fixed with either standard lag and cortical AO/ASIF screws (Group A), or HA-coated lag and cortical AO/ASIF screws (Group B). Lag screw cutout occurred in four patients in Group A, but not in any patients in Group B. In Group A, the femoral neck shaft angle was 134 degrees +/- 5 degrees postoperatively and 127 degrees +/- 12 degrees at 6 months. In Group B, the femoral neck shaft angle was 134 degrees +/- 7 degrees postoperatively and 133 degrees +/- 7 degrees at 6 months. The Harris hip score at 6 months was 60 +/- 25 in Group A and 71 +/- 18 in Group B. The superior results of Group B can be attributed to the increased screw fixation provided by the HA-coated screws. We recommend lag screws coated with HA for dynamic hip screw fixation, especially in osteoporotic bone.
- Published
- 2004
33. Shoulder Function After Cardioverter-Defibrillator Implantation: 5-Year Follow-up
- Author
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Giuseppe Boriani, Matteo Ziacchi, Mauro Biffi, Giulia Massaro, Cristian Martignani, Giuseppe Porcellini, Francesco Pegreffi, Igor Diemberger, Andrea Mazzotti, Martignani C., Massaro G., Mazzotti A., Pegreffi F., Ziacchi M., Biffi M., Porcellini G., Boriani G., and Diemberger I.
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Time Factors ,5 year follow up ,Time Factor ,Prognosi ,030204 cardiovascular system & hematology ,Pain rating ,Follow-Up Studie ,Sudden cardiac death ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Retrospective Studie ,Surveys and Questionnaires ,Shoulder function ,Humans ,Surveys and Questionnaire ,Medicine ,Range of Motion, Articular ,Retrospective Studies ,Mild pain ,Shoulder Joint ,business.industry ,Arrhythmias, Cardiac ,Middle Aged ,Prognosis ,medicine.disease ,Defibrillators, Implantable ,Surgery ,Icd implantation ,Death, Sudden, Cardiac ,030228 respiratory system ,Quality of Life ,Female ,Constant score ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,Human - Abstract
Background Implantable cardioverter-defibrillator (ICD) represents the main tool for prevention of sudden cardiac death. Different kinds of postimplant complications have been described; however, little is known about shoulder functional impairment and its impact on quality of life. Methods Patients with standard indications for elective prepectoral subcutaneous ICD insertion were enrolled during a 1-year period. The impact of ICD implantation on shoulder motility, pain, general disability, and quality of life was evaluated prospectively at baseline, and after 2 weeks, 3 months, 1 year, and 5 years using the Constant score, the Numeric Pain Rating Scale, the Disabilities of the Arm, Shoulder, and Hand scale, and the Short Form-36 Health Survey questionnaire. Results A total of 50 patients underwent insertion of single, dual chamber, or biventricular ICDs. Two weeks after implantation, functional impairment and mild pain were observed in ipsilateral shoulder movements, with a reduction in the Short Form-36 Health Survey score. Shoulder functional impairment improved at the third-month evaluations, with almost normalization at 1-year and 5-year assessments, as well as pain and quality of life. Conclusions Prepectoral subcutaneous ICD implantation may be associated with ipsilateral shoulder functional impairment that regresses partially after 3 months and completely at 1-year and 5-year assessments. The less invasive implantation technique and the relatively small size of modern ICDs, independently from types and volumes, may be relevant to the degree of postimplantation shoulder functional impairment and recovery time. Shoulder function should be assessed at routine checks, especially soon after ICD implantation because of potential functional impairment and subsequent impact on quality of life.
- Published
- 2020
34. JOURNAL OF PURE POWER JOPP.
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Sato, K., Ferreira, S. L. A., Kimitake, S., Heise, G., Kay, A., Blazewich, A., Shinkle, J., Rønnestad, B., Tsong-Rong, J., Da Luz, C. R., Andreoli, A., Walters, P. H., McDowall, J. A, Mesagno, C., and Pegreffi, F.
- Subjects
- *
PHYSICAL fitness , *SQUAT (Weight lifting) , *BENCH press , *DEAD lift (Weight lifting) , *BONE density , *SKELETAL maturity , *PHYSIOLOGICAL aspects of aging - Abstract
The article offers information related to body strength. It states that squat is the best exercise to develop lower body and posterior core strength. It mentions that powerlifting contends maximal strength in bench press, deadlift, and squat. It adds that exercise is critically important for the bone health of women since the loss of bone strength can be their problem as they age.
- Published
- 2012
35. Implantation of cardioverter-defibrillator: Effects on shoulder function
- Author
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Giuseppe Boriani, Matteo Ziacchi, Angelo Branzi, Claudio Tentoni, Elia Foschi, Mauro Biffi, Giuseppe Porcellini, Cristian Martignani, Igor Diemberger, Francesco Grigioni, Andrea Mazzotti, Francesco Pegreffi, Guido Belli, Pasqualino Maietta Latessa, Diemberger I, Pegreffi F, Mazzotti A, Foschi E, Martignani C, Belli G, Biffi M, Ziacchi M, Branzi A, Grigioni F, Maietta Latessa P, Porcellini G, Tentoni C, and Boriani G.
- Subjects
Male ,Shoulder ,medicine.medical_specialty ,Implantable defibrillator ,Heart failure ,Shoulder impingement ,Shoulder pain ,Aged ,Defibrillators, Implantable ,Female ,Follow-Up Studies ,Health Surveys ,Humans ,Middle Aged ,Prospective Studies ,Surveys and Questionnaires ,Treatment Outcome ,Cardiology and Cardiovascular Medicine ,Quality of life ,Dash ,medicine ,Shoulder function ,Numeric Rating Scale ,shoulder function ,IMPLANTABLE CARDIOVERTER DEFIBRILLATOR ,Prospective cohort study ,business.industry ,medicine.disease ,Surgery ,Physical therapy ,Implant ,business - Abstract
BACKGROUND: Subcutaneous almost substituted subpectoral approach of implantable cardioverter-defibrillator (ICD) implantation as a less invasive surgical technique. However, the impact of this change in placement site on procedure-related shoulder impairment is poorly understood. METHODS: Candidates for ICD implantation were prospectively evaluated at baseline, 2-weeks and 3-months after the procedure. Assessment of shoulder function included: Constant Score, Numeric Rating Scale (NRS) for pain and the Disability of the Arm, Shoulder and Hand (DASH) scoring method. The Short Form-36 (SF-36) questionnaire was adopted for quality of life. RESULTS: Fifty consecutive patients were enrolled (21 single-chamber, 5 dual-chamber and 24 biventricular ICD). Significant changes in the short term were observed: physical component summary (regarding SF-36) decreased from 44.5±9.1 to 41.8±11.4 (p=0.016), patients with NRS >1 increased from 14% to 44% (p
- Published
- 2013
36. Innovative Methods of Rapid Bacterial Quantification and Applicability in Diagnostics and in Implant Materials Assessment
- Author
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Carla Renata Arciola, Pietro Speziale, Davide Campoccia, Francesco Pegreffi, Y. H. An, Lucio Montanaro, J.L. del Pozo, L. Ceresa, Campoccia D, Speziale P, An YH, Del Pozo JL, Ceresa L, Pegreffi F, Montanaro L, and Arciola CR
- Subjects
Microbiological Techniques ,Prosthesis-Related Infections ,Surface Properties ,Emerging technologies ,Computer science ,030232 urology & nephrology ,Biomedical Engineering ,Medicine (miscellaneous) ,Biocompatible Materials ,Bioengineering ,Nanotechnology ,Prosthesis Design ,01 natural sciences ,MICROBIOLOGICAL TESTING ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Long period ,Materials Testing ,Humans ,IMPLANT MATERIALS ,Tissue Engineering ,RAPID METHODS FOR BACTERIAL QUANTIFICATION ,010401 analytical chemistry ,Reproducibility of Results ,Prostheses and Implants ,General Medicine ,0104 chemical sciences ,Molecular Diagnostic Techniques ,Biochemical engineering - Abstract
In recent years, a variety of new technologies have been proposed that allow rapid qualitative and quantitative microbiological analyses. In this paper we discuss the urgent needs for reliable and rapid microbiological analytical techniques in different applicative fields involving the research, production and medical application of implant materials, and the potential benefits derived from the use of new methods for rapid bacterial quantification. Current compendial methods are easy to perform and have gained confidence over their long period of use, but the supplemental use of new technologies could represent real breakthroughs whenever sensitive and rapid responses are urgently required and not met by the tests currently in use. Overall, the new microbiological methods require critical evaluation depending on their specific type of application and they may still not be thought of as totally substitutive, but they certainly exhibit considerable potential for different areas of biomaterials, as well as for advanced therapy medicinal and tissue engineering treatments.
- Published
- 2007
37. Comparing Dynamic Hip Screw to External Fixation for Treatment of Osteoporotic Pertrochanteric Fractures: A Prospective Randomized Study
- Author
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Francesca Vannini, Cesare Faldini, Antonio Moroni, Sandro Giannini, Francesco Pegreffi, Amy Hoang-Kim, Moroni A., Faldini C., Pegreffi F., Hoang-Kim A., Vannini F., and Giannini S.
- Subjects
Trochanteric fractures ,medicine.medical_specialty ,Dynamic hip screw ,business.industry ,Mechanical Engineering ,medicine.medical_treatment ,Treatment options ,Surgery ,External fixation ,Fixation (surgical) ,Mechanics of Materials ,medicine ,General Materials Science ,Prospective randomized study ,In patient ,business ,Fracture type ,Biomedical engineering - Abstract
External fixation has proven to be a viable minimally invasive treatment option for elderly patients with trochanteric fractures. Postoperative complications has limited external fixation in relation to inadequate pin fixation. We compared Orthofix pertrochanteric fixator (OPF) with hydroxyapatite-coated pins to dynamic hip screw (DHS) with AO/ASIF stainless-steel screws in osteoporotic trochanteric fractures. Methods: Forty patients were divided into two groups and randomized for treatment with 135° 4-hole DHS (Group A) or OPF with four hydroxyapatite-coated pins (Group B). Inclusion criteria was: female, age ≥ 65 years, AO fracture type A1 or A2 and BMD lower than -2.5 T-score. All fixators were removed at 3 months. Results: There were no differences in patient age, fracture type, BMD, ASA, hospital stay and reduction quality. Average number of blood transfusions was 2.0 ± 0.1 in Group A, whereas there were none in Group B (p < 0.0001). Operative time was 64 ± 6 minutes in Group A and 34 ± 5 in Group B (p < 0.005). Post-operative femoral neck shaft angle was 134 ± 6° in Group A, and 132 ± 4° in Group B (ns). In Group A, fracture varization at 6 months was 6 ± 8°, in Group B 2 ± 1° (p = 0.002). Harris hip score was 62 ± 20 in Group A and 63 ± 17 in Group B. (n.s.) In Group B, no pin infection occurred. Pin fixation was maintained over time, as shown by no significant difference between pin extraction and corresponding insertion torque. Discussion and Conclusion: In external fixation with hydroxyapatite-coated pins there was no need for blood transfusions and fixation was superior, as confirmed by less varization at long-term.
- Published
- 2005
38. Muscle activation during push-up exercise under stable and instable conditions
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BELLI, GUIDO, CIACCI, SIMONE, PEGREFFI, FRANCESCO, FANTOZZI, SILVIA, Rudatis A., Belli G., Ciacci S., Rudatis A., Pegreffi F., and Fantozzi S.
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EMG, push-up, strength training - Published
- 2014
39. Biofilm extracellular-DNA in 55 Staphylococcus epidermidis clinical isolates from implant infections
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Francesco Pegreffi, Davide Campoccia, Claudio Poggio, Alessandra Maso, Tolmino Corazzari, Ilaria Cangini, Livia Visai, Valter Pirini, Lucio Montanaro, Stefano Ravaioli, Carla Renata Arciola, Ravaioli S, Campoccia D, Visai L, Pirini V, Cangini I, Corazzari T, Maso A, Poggio C, Pegreffi F, Montanaro L, and Arciola CR
- Subjects
DNA, Bacterial ,Prosthesis-Related Infections ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,Ribotyping ,Virulence factor ,Implant orthopedic infections ,EXTRACELLULAR DNA ,Microbiology ,Biomaterials ,Staphylococcus epidermidis ,Extracellular DNA ,Deoxyribonuclease I ,Humans ,Fluorometry ,Biofilm ,Exopopolysaccaride ,biology ,Polysaccharides, Bacterial ,Implant Infection ,General Medicine ,Staphylococcal Infections ,biology.organism_classification ,Extracellular dna ,Italy ,Biofilms ,IMPLANT ORTHOPEDIC INFECTIONS ,EXOPOPOLYSACCARIDE ,BIOFILM - Abstract
Biofilm formation is broadly recognized as an important virulence factor in many bacterial species implicated in implant-related opportunistic infections. In spite of a long history of research and many investigative efforts aimed at elucidating their chemical composition, structure, and function, the nature of bacterial biofilms still remains only partly revealed. Over the years, different extracellular polymeric substances (EPS) have been described that contribute functionally and structurally to the organization of biofilms. Recently extracellular DNA (eDNA) has emerged as a quantitatively conspicuous and potentially relevant structural component of microbial biofilms of many microbial species, Staphylococcus aureus and S. epidermidis among them. The present study aims at comparatively investigating the amount of eDNA present in the biofilm of 55 clinical isolates of S. epidermidis from postsurgical and biomaterial-related orthopedic infections. Quantification of eDNA was performed by a non-destructive method directly on bacterial biofilms formed under static conditions on the plastic surface of 96-well plates.
- Published
- 2011
40. Panton-Valentine leukocidin gene detected in Staphylococcus aureus strain isolated from a knee arthroprosthesis infection
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Tolmino Corazzari, Lucio Montanaro, Stefano Ravaioli, Pietro Speziale, Francesco Pegreffi, M. Elena Donati, Ilaria Cangini, Davide Campoccia, Valter Pirini, Carla Renata Arciola, Livia Visai, Roberta Creti, Lucilla Baldassarri, Alessandra Maso, Montanaro L, Baldassarri L, Corazzari T, Creti R, Ravaioli S, Cangini I, Pirini V, Maso A, Donati ME, Pegreffi F, Visai L, Campoccia D, Speziale P, and Arciola CR
- Subjects
Replacement ,adverse effects/instrumentation ,Antibiotics ,030232 urology & nephrology ,Leukocidin ,Medicine (miscellaneous) ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Adhesins ,Bacterial ,genetics, Arthroplasty ,Knee ,adverse effects/instrumentation, Bacterial Proteins ,genetics, Bacterial Toxins ,genetics, Carrier Proteins ,genetics, Exotoxins ,genetics, Gene Expression Regulation ,Bacterial, Genotype, Humans, Knee Prosthesis ,adverse effects, Leukocidins ,genetics, Methicillin Resistance ,genetics, Middle Aged, Phenotype, Prosthesis-Related Infections ,microbiology, Staphylococcus aureus ,genetics/isolation /&/ purification, Trans-Activators ,genetics ,ARTHROPROSTHESIS INFECTION ,0302 clinical medicine ,Leukocidins ,STAPHYLOCOCCUS AUREUS (CA-MRSA AND CA-MSSA) ,MECA GENE ,Arthroplasty, Replacement, Knee ,Strain (chemistry) ,AGR POLYMORPHISMS ,General Medicine ,genetics/isolation /&/ purification ,Middle Aged ,Phenotype ,Staphylococcus aureus ,Knee Prosthesis ,Prosthesis-Related Infections ,Genotype ,medicine.drug_class ,Bacterial Toxins ,Biomedical Engineering ,Exotoxins ,Bioengineering ,Biology ,Arthroplasty ,Microbiology ,PANTON-VALENTINE TOXIN ,Biomaterials ,03 medical and health sciences ,Bacterial Proteins ,medicine ,Humans ,Penicillin-Binding Proteins ,Adhesins, Bacterial ,Genotyping ,SCCmec ,microbiology ,Gene Expression Regulation, Bacterial ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,Virology ,Bacterial adhesin ,Gene Expression Regulation ,adverse effects ,Trans-Activators ,Methicillin Resistance ,Panton–Valentine leukocidin ,Carrier Proteins - Abstract
This report focuses on the molecular characterization of a Staphylococcus aureus strain isolated from a knee arthroprosthesis infection and recognized retrospectively as a carrier of the Panton-Valentine leukocidin gene. The stored microbiological isolate, which belonged to the strain collection of the Research Unit on Implant Infections of the Rizzoli Orthopaedic Institute, was retrieved for molecular analysis. Genotyping was carried out, revealing an interesting profile. In addition to the positivity for the Panton-Valentine toxin gene, the results indicated that the isolate belonged to the agr III group and was endowed with bbp and cna genes, both encoding for staphylococcal adhesins that bind bone proteins. The strain had the mecA gene for methicillin resistance, even though it was unable to resist any of the β-lactam or other antibiotics. Its gene configuration matched that of other community-acquired methicillin-resistant and methicillin-susceptible Staphylococcus aureus (CA-MRSA and CA-MSSA) strains which have recently been reported worldwide. As far as we know, this is the first report on a PVL-positive S. aureus strain associated with an orthopedic implant (knee arthroprosthesis) infection.
- Published
- 2009
41. Reperizzazione manuale della scapola per la determinazione dell’orientamento: proposta metodologica
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TENTONI, CLAUDIO, MAIETTA LATESSA, PASQUALINO, FOSCHI, ELIA, LA ROSA, GIOVANNI, PORCELLINI, GIUSEPPE, CORAZZA, IVAN, PEGREFFI, FRANCESCO, BELLI G., TENTONI C., MAIETTA LATESSA P., FOSCHI E., BELLI G., LA ROSA G., PORCELLINI G., CORAZZA I., and PEGREFFI F.
- Subjects
PUNTI DI REPERE ,SCAPOLA ,DISORDINI POSTURALI - Abstract
Scopo: Questo studio si propone di verificare l’esatta corrispondenza tra punti di repere cutanei ed ossei al fine di proporre una metodologia di reperizzazione manuale. Metodo: 30 soggetti sono stati selezionati casualmente tra un vasto gruppo di pazienti. Per ogni soggetto il chinesiologo individua manualmente il margine mediale della scapola ed evidenzia due punti ad esso corrispondenti. Il paziente viene posizionato dal tecnico radiologo per eseguire l’esame radiografico programmato per accertamenti clinici indipendenti da questo studio. Con apposito software (Autocad Light) è stato calcolato l’angolo formato dal margine mediale vero (MMv) e quello formato dal margine mediale reperizzato (MMr). Risultati: L’analisi statistica ha evidenziato una differenza non significativa (p>0,8) tra MMv ed MMr. Discussione: Il nostro studio propone una semplice metodologia della reperizzazione manuale. I dati ottenuti dimostrano che non esistono differenze significative fra i reperi cutanei e i reperi ossei. Conclusioni: la metodologia da noi proposta è risultata di facile applicabilità, assolutamente non invasiva e ripetibile. Parole chiave: scapola, punti di repere
- Published
- 2009
42. Fixation of HA-coated unicortical locking screws in a sheep gap model: a comparative biomechanical study
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Federico Tesei, Burkhardt Wippermann, Antonio Moroni, Amy Hoang-Kim, Sandro Giannini, Francesco Pegreffi, A. Moroni, Pegreffi F, Hoang-Kim A, Tesei F, Giannini S, and Wippermann B.
- Subjects
medicine.medical_specialty ,Bone Screws ,Fixation (surgical) ,Fracture Fixation, Internal ,Coated Materials, Biocompatible ,medicine ,Animals ,Orthopedics and Sports Medicine ,Orthodontics ,Fracture Healing ,Sheep ,Tibia ,business.industry ,Model study ,Biomechanics ,General Medicine ,Resection/osteotomy ,Surgery ,Biomechanical Phenomena ,Osteotomy ,Tibial Fractures ,Durapatite ,Models, Animal ,Equipment Failure ,business ,Bone Plates - Abstract
To evaluate whether fixing a locking compression plate (LCP) with hydroxyapatite (HA)-coated screws provides improved biomechanical fixation and healing compared with standard screws under loaded conditions.Ten sheep were randomly divided into 2 groups. A resection osteotomy of 8 mm was performed in the sheep's right tibiae. Five tibiae were fixed with a 9-hole LCP and 8 standard unicortical locking screws (Group Non-HA), and 5 tibiae were fixed with a 9-hole LCP and 8 HA-coated unicortical locking screws (Group HA). All screws were implanted at the same insertion torque of 4000 Nmm. Three months after surgery, all the sheep were euthanized. Bone segments after screw removal were randomly chosen from each group for histologic analysis (Group Non-HA=5, Group HA=5).Mean screw extraction torque was 438+/-288 Nmm in Group Non-HA (n=40) and 2317+/-657 Nmm in Group HA (n=40) (P0.0005). The tibial torque resistance of the resected tibiae was 24+/-8 Nm in Group Non-HA (n=5) and 31+/-3 in Group HA (n=5) (P=0.045). In Group Non-HA, histology showed bone resorption and fibrous tissue encapsulation in all the samples, but this was not found in any of the Group HA samples.This study shows that an LCP with HA-coated screws provides improved biomechanical fixation than an LCP with similar standard screws as shown by a 5-fold greater screw extraction torque (P0.0005). Furthermore, the higher tibial torque resistance is potentially beneficial for improved gap healing, as shown by higher tibial torque resistance.
- Published
- 2008
43. Automated ribotyping to distinguish the different non Sau/ non Sep staphylococcal emerging pathogens in orthopedic implant infections
- Author
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Q.K. Kang, S. Gamberini, Francesco Pegreffi, Davide Campoccia, Y. H. An, Carla Renata Arciola, Lucilla Baldassarri, Valter Pirini, Lucio Montanaro, Campoccia D., Baldassarri L., An Y.H., Kang Q.K., Pirini V., Gamberini S., Pegreffi F., Montanaro L., and Arciola C.R.
- Subjects
Staphylococcus ,030232 urology & nephrology ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,030204 cardiovascular system & hematology ,Biology ,medicine.disease_cause ,Staphylococcal infections ,Ribotyping ,Microbiology ,Biomaterials ,03 medical and health sciences ,Automation ,0302 clinical medicine ,fluids and secretions ,Species Specificity ,Staphylococcus epidermidis ,medicine ,Humans ,Orthopedic implant ,AUTOMATED RIBOTYPING ,STAPHYLOCOCCUS SPECIES ,IMPLANT INFECTIONS ,Orthopedic Equipment ,General Medicine ,Staphylococcal Infections ,biology.organism_classification ,medicine.disease ,equipment and supplies ,bacterial infections and mycoses ,OPPORTUNISTIC PATHOGENS ,Staphylococcus aureus ,Metabolic profile - Abstract
Several species belonging to Staphylococcus genus, other than Staphylococcus aureus and Staphylococcus epidermidis (nonSau/ nonSep species), exhibit increasing abilities as opportunistic pathogens in the colonisation of periprosthetic tissues. Consequently, the availability of means for accurate identification is crucial to assess the pathogenic characteristics and to clarify clinical relevance of the individual species. Here, 146 clinical staphylococcal isolates belonging to nonSau/ nonSep species from prosthesis-associated orthopedic infections were analyzed by conventional enzymatic galleries and by automated ribotyping. Twelve different species were recognised: S. capitis, S. caprae, S. cohnii, S. equorum, S. haemolyticus, S. hominis, S. lugdunensis, S. pasteuri, S. sciuri, S. simulans, S. warneri, S. xylosus. Ribotype identifications were compared with the phenotypes obtained by the Api 20 Staph system and/or ID 32 Staph system. ID 32 Staph profiles were more consistent with ribotyping results than Api Staph profiles. Across the different staphylococcal species investigated, correct identifications with Api Staph were 45%, while with ID 32 Staph they were 59%. It has, however, to be mentioned that ID 32 Staph was mostly applied to discriminate unmatched ribotyping and Api Staph identifications, thus to a subpopulation of strains with “atypical” metabolic profile. Automated ribotyping provided a correct identification for 91% of the isolates. These results confirm automated ribotyping as a convenient rapid technique, still subject to improvements, which will accurately and rapidly recognise the newly emerging staphylococcal pathogens in implant-related orthopedic infections.
- Published
- 2006
44. Cast vs external fixation: a comparative study in elderly osteoporotic distal radial fracture patients
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Cesare Faldini, Sandro Giannini, Francesca Vannini, Francesco Pegreffi, Antonio Moroni, MORONI A., VANNINI F, FALDINI C, PEGREFFI F, GIANNINI S., Moroni, Antonio, F., Vannini, C., Faldini, F., Pegreffi, and S., Giannini
- Subjects
medicine.medical_specialty ,Radiography ,medicine.medical_treatment ,Bone Screws ,Dentistry ,Bone Nails ,Group B ,law.invention ,03 medical and health sciences ,External fixation ,0302 clinical medicine ,Randomized controlled trial ,Fracture Fixation ,law ,Deformity ,Humans ,Medicine ,Aged ,Bone mineral ,business.industry ,Surgery ,Casts, Surgical ,Treatment Outcome ,030220 oncology & carcinogenesis ,Fracture (geology) ,Osteoporosis ,Female ,030211 gastroenterology & hepatology ,WRIST FRACTURE ,medicine.symptom ,Radius Fractures ,business - Abstract
Aim:This study compared fracture treatment with plaster cast vs external fixation.Methods:Forty elderly female osteoporotic wrist fracture patients were randomized to be treated with either plaster cast (Group A) or external fixation (Group B). Bone mineral density less than −2.5 T-score was among the inclusion criteria.Results:In Group A, four redisplacements occurred, whereas in Group B there were none (p = 0.005). Horesh score was higher in Group B (p < 0.006) than in Group A. Volar angle deformity (p < 0.0005) and radial angle deformity (p = 0.008) were lower in Group B.Conclusions:This study shows that external fixation improves stability in elderly osteoporotic wrist fracture patients.
- Published
- 2004
45. Characterization of 26 Staphylococcus warneri isolates from orthopedic infections
- Author
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Davide Campoccia, Livia Visai, Tolmino Corazzari, Pietro Speziale, Alessandra Maso, Carla Renata Arciola, Ilaria Cangini, Claudio Poggio, Stefano Ravaioli, Lucio Montanaro, Francesco Pegreffi, Valter Pirini, Campoccia D, Montanaro L, Visai L, Corazzari T, Poggio C, Pegreffi F, Maso A, Pirini V, Ravaioli S, Cangini I, Speziale P, and Arciola CR.
- Subjects
DNA, Bacterial ,Prosthesis-Related Infections ,STAPHYLOCOCCUS WARNERI ,Staphylococcus ,030232 urology & nephrology ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,Drug resistance ,030204 cardiovascular system & hematology ,Biology ,medicine.disease_cause ,Ribotyping ,Microbiology ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Antibiotic resistance ,Disk Diffusion Antimicrobial Tests ,Intensive care ,Drug Resistance, Bacterial ,ANTIBIOTIC RESISTANCE ,medicine ,Humans ,Surgical Wound Infection ,Orthopedic Procedures ,Antibacterial agent ,Virulence ,General Medicine ,biology.organism_classification ,Anti-Bacterial Agents ,ORTHOPEDIC IMPLANT INFECTIONS ,RNA, Ribosomal ,Staphylococcus warneri ,Coagulase - Abstract
Staphylococcus warneri is a coagulase negative Staphylococcus (CNS) commonly present in the flora of human epithelia and mucosal membranes. Over the last two decades, similarly to other CNS species, S. warneri has been reported as a new emerging pathogen, capable of causing serious infections usually in association with the presence of implant materials, but, at times, even in the absence of a foreign body and in patients considered immunocompetent. At present, there is still a lack of scientific data on the pathogenesis and epidemiology of this species. The present study investigated a collection of 26 clinical isolates derived from orthopedic infections, some associated with implant materials and others not. Automated ribotyping showed the existence of 5 distinct ribogroups. Except for the least numerous ribogroup consisting of a single isolate, all other ribogroups included at least one strain obtained from an infection not associated with implant materials, suggesting that putative virulence factors necessary for infections even in the absence of a foreign body could be transversal to most ribogroup categories. Orthopedic infections were found to involve S. warneri strains with low antibiotic resistance potential, differing in this respect from the strains isolated at neonatal intensive care units, where this species has been described to figure among the principal causative agents and exhibit an alarming profile of antibiotic resistance.
46. Prevalence and antibiotic resistance of 15 minor staphylococcal species colonizing orthopedic implants
- Author
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Valter Pirini, Lucio Montanaro, Davide Campoccia, Lucilla Baldassarri, Carla Renata Arciola, Y. H. An, M. E. Donati, Francesco Pegreffi, Arciola C.R., Campoccia D., An Y.H., Baldassarri L., Pirini V., Donati M.E., Pegreffi F., and Montanaro L.
- Subjects
Imipenem ,medicine.drug_class ,Antibiotics ,030232 urology & nephrology ,Biomedical Engineering ,Medicine (miscellaneous) ,Erythromycin ,Virulence ,Bioengineering ,ORTHOPEDIC IMPLANTS ,Drug resistance ,030204 cardiovascular system & hematology ,Biology ,medicine.disease_cause ,EMERGING PATHOGENS ,Microbiology ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Antibiotic resistance ,Species Specificity ,Drug Resistance, Multiple, Bacterial ,medicine ,Prevalence ,ANTIBIOTIC RESISTANCE ,Humans ,COAGULASE-NEGATIVE STAPHYLOCOCCI ,STAPHYLOCOCCUS ,General Medicine ,Prostheses and Implants ,Staphylococcal Infections ,Anti-Bacterial Agents ,Colonisation ,Orthopedics ,Staphylococcus ,medicine.drug - Abstract
Several species belonging to Staphylococcus genus (nonSau/nonSep species) exhibit increasing abilities as opportunistic pathogens in colonisation of periprosthesis tissues. Here we report on antibiotic resistance of 193 strains, belonging to nonSau/nonSep species, consecutively collected from orthopedic implant infections in a period of about 40 months. The 193 strains (representing 17% of all staphylococci isolated) were analysed for their antibiotic resistance to 16 different drugs. Five species turned out more prevalent, ranging from 1 to 5%: S. hominis (4.2%), S. haemolyticus (3.7%), S. capitis (2.7%), S. warneri (2.6%), and S. cohnii (1.6%). Among these, the prevalence of antibiotic resistance to penicillins was similar, ranging from 51% to 66%. Conversely, significant differences were observed for all the remaining antibiotics. For S. haemolyticus the resistances to oxacillin and imipenem, the four aminoglycosides and erythromycin were at least twice that of the other three species which were compared. S. warneri was on the contrary the species with the lowest occurrence of resistant strains. Ten species appeared only rarely at the infection sites: S. lugdunensis, S. caprae, S. equorum, S. intermedius, S. xylosus, S. simulans, S. saprophyticus, S. pasteuri, S. sciuri, and S. schleiferi. The behaviours of these species, often resistant to penicillins, were individually analysed. Differences in both the frequencies and the panels of antibiotic resistances observed among the nonSau/nonSep species: i) suggest that horizontal spreading of resistance factors, if acting, was not sufficient per se to level their bio-diversities; ii) highlight and confirm the worrisome appearance within the Staphylococcus genus of emerging “new pathogens”, not homogeneous for their virulence and antibiotic resistance prevalence, which deserve to be recognised and treated individually.
47. Sarcopenic obesity and health outcomes: An umbrella review of systematic reviews with meta-analysis.
- Author
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Veronese N, Ragusa FS, Pegreffi F, Dominguez LJ, Barbagallo M, Zanetti M, and Cereda E
- Subjects
- Humans, Systematic Reviews as Topic, Sarcopenia epidemiology, Obesity complications, Obesity epidemiology
- Abstract
Many studies support the idea that sarcopenic obesity (SO) could be considered a potential risk factor for negative health outcomes. These results have been inconsistent, and no umbrella reviews exist regarding this topic. Several databases until November 2023 were searched for systematic reviews with meta-analysis of observational studies (cross-sectional, case-control and prospective). For each association, random-effects summary effect sizes with correspondent 95% confidence intervals (CIs) were evaluated using the GRADE tool. Among the 213 papers initially screened, nine systematic reviews with meta-analysis were included, for a total of 384 710 participants. In cross-sectional and case-control studies, 30 different outcomes were analysed, and 18 were statistically significant. In any population addressed in cross-sectional and case-control studies, compared with non-SO, SO increased the prevalence of cognitive impairment (k = 3; odds ratio [OR] = 3.46; 95% CI: 2.24-5.32; high certainty of evidence), coronary artery disease (k = 2; OR = 2.48; 95% CI: 1.85-3.31) and dyslipidaemia (k = 3; OR = 2.50; 95% CI: 1.51-4.15). When compared with sarcopenia or obesity, the results were conflicting. In prospective studies, the association between SO-compared with non-SO-and other negative outcomes was supported by low/very low certainty of evidence and limited to a few conditions. Besides, no comparison with sarcopenia or obesity was provided. Finally, only a few studies have considered muscle function/physical performance in the diagnostic workup. SO could be considered a risk factor only for a few conditions, with the literature mainly based on cross-sectional and case-control studies. Future studies with clear definitions of SO are needed for quantifying the importance of SO-particularly when compared with the presence of only sarcopenia or obesity-and the weight of muscle function/physical performance in its definition., (© 2024 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
48. Periodontal Health and Its Relationship with Psychological Stress: A Cross-Sectional Study.
- Author
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Macrì M, D'Albis G, D'Albis V, Antonacci A, Abbinante A, Stefanelli R, Pegreffi F, and Festa F
- Abstract
Background : Studies suggest that chronic psychological stress can lead to oral health deterioration, alter the immune response, and possibly contribute to increased inflammation, which can impact the physiological healing of periodontal tissues. This cross-sectional study seeks to assess and improve clinical understanding regarding the relationship between perceived stress, mindfulness, and periodontal health. Methods : A total of 203 people were analyzed from December 2022 to June 2023. The Periodontal Screening and Recording (PSR) score and Gingival Bleeding Index (GBI), and Plaque Control Record (PCR) of every patient were registered. Subsequently, participants completed the Sheldon Cohen Perceived Stress Scale (PSS) and the Mindfulness Awareness Attention Scale (MAAS) questionnaires. The collected data underwent statistical analysis, encompassing the evaluation of correlations and dependencies. Applying Welch's t -test to assess the relationship between MAAS and the variable indicating the presence or absence of periodontitis, a noteworthy p -value of 0.004265 was obtained. Results : This underscores a significant distinction in MAAS scores between patients affected by periodontitis and those unaffected by the condition. Additionally, Pearson correlations were computed for GBI and perceived stress, PCR and perceived stress, PCR and MAAS. The resulting p -values of 2.2-16, 3.925-8, and 2.468-8, respectively, indicate a statistically significant correlation in each instance. Conclusions : These findings contribute valuable insights into the interconnectedness of these variables, emphasizing the significance of their associations in the study context. Despite the limitations, the findings of this study suggest a significant relationship between psychological stress, mindfulness, and periodontal tissue health. Clinical trials are necessary to incorporate the assessment of a patient's psychological status as a new valuable tool in the management of periodontal health.
- Published
- 2024
- Full Text
- View/download PDF
49. Sarcopenia in gynaecological cancers.
- Author
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Di Fiore R, Drago-Ferrante R, Suleiman S, Veronese N, Pegreffi F, and Calleja-Agius J
- Abstract
Gynaecological cancers (GCs) comprise a group of cancers that originate in the female reproductive organs. Each GC is unique, with different signs and symptoms, risk factors and therapeutic strategies. Worldwide, the majority of GCs are still associated with high mortality rates, especially ovarian, due to difficulty in early detection. Despite numerous studies on the underlying pathophysiology, research in the field of GCs poses unique scientific and technological challenges. These challenges require a concerted multi- and inter-disciplinary effort by the clinical, scientific and research communities to accelerate the advancement of prognostic, diagnostic, and therapeutic approaches. Sarcopenia is a multifactorial disease which leads to the systemic loss of skeletal muscle mass and function. It can be caused by malignancies, as well as due to malnutrition, physical inactivity, ageing and neuromuscular, inflammatory, and/or endocrine diseases. Anorexia and systemic inflammation can shift the metabolic balance of patients with cancer cachexia towards catabolism of skeletal muscle, and hence sarcopenia. Therefore, sarcopenia is considered as an indicator of poor general health status, as well as the possible indicator of advanced cancer. There is a growing body of evidence showing the prognostic significance of sarcopenia in various cancers, including GCs. This review will outline the clinical importance of sarcopenia in patients with GCs., Competing Interests: Declaration of competing interest None., (© 2024 Elsevier Ltd, BASO ∼ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.)
- Published
- 2024
- Full Text
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50. Sarcopenia increases mortality risk in liver transplantation: a systematic review and meta-analysis.
- Author
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Prokopidis K, Affronti M, Testa GD, Ungar A, Cereda E, Smith L, Pegreffi F, Barbagallo M, and Veronese N
- Subjects
- Humans, Risk Factors, Female, Middle Aged, Male, Risk Assessment, Liver Cirrhosis mortality, Liver Cirrhosis surgery, Liver Cirrhosis complications, Prognosis, Aged, Adult, Treatment Outcome, Sarcopenia mortality, Sarcopenia complications, Sarcopenia diagnosis, Liver Transplantation mortality, Liver Transplantation adverse effects
- Abstract
Introduction: Liver transplantation is an efficacious treatment option for those with liver cirrhosis. However, the prognostic role of sarcopenia in these patients is unknown. Given this background, we conducted a systematic review and meta-analysis of the impact of sarcopenia on mortality in patients listed, evaluated and undergoing liver transplantation., Evidence Acquisition: Several databases were searched from the inception to December 2022 for observational studies regarding sarcopenia in liver transplant and mortality. We calculated the risk of mortality in sarcopenia vs. no sarcopenia using the most adjusted estimate available and summarizing the data as risk ratios (RRs) with their 95% confidence intervals (CIs). A random-effect model was considered for all analyses., Evidence Synthesis: Among 1135 studies initially considered, 33 articles were included for a total of 12,137 patients (mean age: 55.3 years; 39.4% females). Over a median of 2.6 years and after adjusting for a median of 3 covariates, sarcopenia increased the risk of mortality approximately 2-fold (RR: 2.01; 95% CI: 1.70-2.36). After accounting for publication bias, the re-calculated RR was 1.75 (95% CI: 1.49-2.06). The quality of the studies was generally low, as determined by the Newcastle Ottawa Scale., Conclusions: Sarcopenia was significantly linked with an increased risk of mortality in patients listed, evaluated, and undergoing a liver transplantation, indicating the need of interventional studies in this special population with the main aim to reverse this potential reversible condition and decrease mortality risk.
- Published
- 2024
- Full Text
- View/download PDF
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