1. Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study
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Ary Serpa Neto, Carmen S V Barbas, Fabienne D Simonis, Antonio Artigas-Raventós, Jaume Canet, Rogier M Determann, James Anstey, Goran Hedenstierna, Sabrine N T Hemmes, Greet Hermans, Michael Hiesmayr, Markus W Hollmann, Samir Jaber, Ignacio Martin-Loeches, Gary H Mills, Rupert M Pearse, Christian Putensen, Werner Schmid, Paolo Severgnini, Roger Smith, Tanja A Treschan, Edda M Tschernko, Marcos F V Melo, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz, Adam Bell, Agreta Gecaj-Gashi, Ahmet Dilek, Ahmet Sukru Denker, Akut Aytulun, Peter Kienbaum, Alastair Rose, Alessandro Bacuzzi, Alexandre Biasi Cavalcanti, Alexandre Chan, Alexandre Molin, Alison Ghosh, Alistair Roy, Amanda Cowton, Amanda Skinner, Amanda Whileman, Amy McInerney, Ana Carolina Peçanha, Andrea Cortegiani, Andrej Sribar, Andrew Bentley, Andrew Corner, Angela Pinder, Anil Hormis, Anna Walker, Barry Dixon, Ben Creagh-Brown, Carlo Alberto Volta, Carlos Munhoz, Carly Brown, Carmen Scott, Caroline Wreybrown, Catherine Plowright, Charlotte Downes, Cheryl Padilla-Harris, Chloe Hughes, Christian Frey, Christian Schlegel, Christine Boyd, Christine Ryan, Christoph Muench, Christopher Smalley, Çiler Zincircioglu, Clair Harris, Claire Kaloo, Claire Matthews, Claire Miller, Claire Pegg, Clare Bullock, Clare Mellis, Claudio Piras, Colette Seasman, Cristina Santos, Daniel Beraldo, Daniel Collins, Daniel Hadfield, Daniel Hull, Daniel Prado, David Pogson, David Rogerson, David Shaw, Davide D'Antini, Dawn Trodd Denise Griffin, Debbie Weller, Deborah Smith, Deborah Wilson, Demet Aydin, Denise Donaldson, Donatella Mestria, Eduardo Di Lauro, Eliane Bernadete Caser, Elisa Seghelini, Emanuel Cirstea, Eoin Young, Erna Alberts, Evren Senturk, Farooq Brohi, Fatma Ulger, Feda Kahveci, Fernando José da Silva Ramos, Frank Van Haren, Güldem Turan, Gabriele Sales, Gayle Clifford, Gilda Cinnella, Giovana Colozza Mecatti, Giuseppe Melchionda, Gulay Eren, Hannah Crowther, Hazel Spencer, Heather Blaylock, Helen Green, Helen Robertson, Helen Rodgers, Helen Talbot, Helen Wong, Helena Barcraft-Barnes, Helga Ceunen, Henrik Reschreiter, Hulya Ulusoy, Huseyin Toman, Iain McCullagh, Ian White, Ingeborg Welters, Ingrid van den Hul, Isabela Ambrósio Gava, Isabelle Reed, Isil Kose, Israel Maia, James Limb, Jan Máca, Jane Adderly, Jane Hunt, Jane Martin, Jane Montgomery, Jane Snell, Jean Salgado, Jenny Ritzema, Jeremy Bewley, Joanne Howe, Johan Decruyenaere, Johanna Mouland, Johanna Stickley, Johannes Mellinghoff, John Criswell, John Knighton, Jonathan Cooper, Jonathan Harrison, Jonathan Paddle, Jose Augusto Santos Pellegrini, Joseph Needleman, Julian Giles, Julie Camsooksai, Julie Furneval, Julie Toms, Karen Burt, Karen Simeson, Karen Williams, Karl Blenk, Kate Turner, Katie Lynch, Katie Sweet, Keith Hugill, Kelly Matthews, Kessia Ruas, Kevin Clarkson, Kobus Preller, Kristen Joyce, Laura Ortiz-Ruiz, Laura Youds, Lee Tbaily, Lisa Barrell, Lisa Grimmer, Lokman Soyoral, Lorenzo Peluso, Lorna Murray, Lotta Niska, Louise Tonks, Lousie Fasting, Luc DeCrop, Luca Brazzi, Lucia Mirabella, Lucy Cooper, Luis Fernando Falcão, Lynn Everett, Malcolm Watters, Mandy Carnahan, Marc Bourgeois, Marcelo Luz Pereira Romano, Marco Botteri, Marcos F Vidal Melo, Maria Faulkner, Marijana Krkusek, Marina Bahl, Mark Holliday, Mark Kol, Mark Pulletz, Marta Kozlowski, Matea Bogdanovic Dvorscak, Matija Jurjevic, Matty Koopmans, Mauricio Morales, Maximilian Schaefer, Melinda Brazier, Meredith Harris, Michael Devile, Michael Kuiper, Michael Parris, Michael Sharman, Milan Kratochvil, Mohamed Ramali, Moreno Calcagnotto dos Santos, Natalie Bynorth, Natalie Wilson, Nathalie Anquez, Nathan Huneke, Nazim Dogan, Nenad Karanovic, Nicholas Tarmey, Nicolás Carreño, Nicola Fisher, Nicola Lamb, Nicola Venner, Nigel Hollister, Nur Akgun, Osman Ekinci, Owen Boyd, Pardeep Gill, Pasquale Raimondo, Pasquale Verrastro, Paul Pulak, Pauline Fitzell, Paulo Dark, Pedro Alzugaray, Perihan Ergin Özcan, Peter MacNaughton, Petr Stourac, Phil Hopkins, Pieter Roel Tuinman, Rachel Pearson, Rachel Walker, Rafaella Souza dos Santos, Raffaele Caione, Ramprasad Matsa, Rebecca Oliver, Reni Jacob, Richard Howard-Griffin, Robert BP de Wilde, Robert Plant, Robin Hollands, Rodrigo Biondi, Rola Jaafar, Rossana Avendaño, Ruth Salt, Ryan Humphries, Sérgio Felix Pinto, Sallyane Pearson, Sam Hendry, Sandeep Lakhani, Sarah Beavis, Sarah Moreton, Sarah Prudden, Sarah Thornthwaite, Savino Spadaro, Sedat Saylan, Shailaja Chenna, Shammer Gopal, Shanaz James, Sheeba Suresh, Sian Birch, Sonja Skilijic, Stefania Aguirre, Stella Metherell, Stephanie Bell, Stephanie Janes, Stephen Wright, Steve Rose, Steve Windebank, Sue Glenn, Susan Melbourne, Susan Tyson, Susannah Leaver, Tasmin Patel, Tatjana Simurina, Terri-Ann Sewell, Tiago Macruz, Tom Hatton, Tracey Evans, Ugur Goktas, Una Poultney, Unase Buyukkocak, Vanessa Linnett, Vanessa Oliveira, Vincenzo Russotto, Vlasta Klaric, Yavuz Orak, Zerrin Demirtürk, Neto, Ary Serpa, Barbas, Carmen S V, Simonis, Fabienne D, Artigas-Raventós, Antonio, Canet, Jaume, Determann, Rogier M, Anstey, Jame, Hedenstierna, Goran, Hemmes, Sabrine N T, Hermans, Greet, Hiesmayr, Michael, Hollmann, Markus W, Jaber, Samir, Martin-Loeches, Ignacio, Mills, Gary H, Pearse, Rupert M, Putensen, Christian, Schmid, Werner, Severgnini, Paolo, Smith, Roger, Treschan, Tanja A, Tschernko, Edda M, Melo, Marcos F V, Wrigge, Hermann, de Abreu, Marcelo Gama, Pelosi, Paolo, Schultz, Marcus J, Bell A, Gecaj-Gashi A, Dilek A, Denker AS, Aytulun A, Kienbaum P, Rose A, Bacuzzi A, Cavalcanti AB, Chan A, Molin A, Ghosh A, Roy A, Cowton A, Skinner A, Whileman A, McInerney A, Peçanha AC, Cortegiani A, Sribar A, Bentley A, Corner A, Pinder A, Hormis A, Walker A, Artigas-Raventós A, Neto AS, Dixon B, Creagh-Brown B, Volta CA, Munhoz C, Brown C, Barbas CSV, Scott C, Wreybrown C, Plowright C, Downes C, Padilla-Harris C, Hughes C, Frey C, Putensen C, Schlegel C, Boyd C, Ryan C, Muench C, Smalley C, Zincircioglu Ç, Harris C, Kaloo C, Matthews C, Miller C, Pegg C, Bullock C, Mellis C, Piras C, Seasman C, Santos C, Beraldo D, Collins D, Hadfield D, Hull D, Prado D, Pogson D, Rogerson D, Shaw D, D'Antini D, Griffin DTD, Weller D, Smith D, Wilson D, Aydin D, Donaldson D, Mestria D, Tschernko EM, Lauro ED, Caser EB, Seghelini E, Cirstea E, Young E, Alberts E, Senturk E, Simonis FD, Brohi F, Ulger F, Kahveci F, da Silva Ramos FJ, Van Haren F, Turan G, Sales G, Mills GH, Mills GH, Clifford G, Cinnella G, Mecatti GC, Melchionda G, Hedenstierna G, Hermans G, Hermans G, Eren G, Crowther H, Spencer H, Blaylock H, Green H, Robertson H, Rodgers H, Talbot H, Wong H, Barcraft-Barnes H, Ceunen H, Reschreiter H, Wrigge H, Wrigge H, Ulusoy H, Toman H, McCullagh I, White I, Martin-Loeches I, Welters I, van den Hul I, Gava IA, Reed I, Kose I, Maia I, Limb J, Máca J, Adderly J, Hunt J, Martin J, Montgomery J, Snell J, Canet J, Salgado J, Ritzema J, Bewley J, Howe J, Decruyenaere J, Mouland J, Stickley J, Mellinghoff J, Criswell J, Knighton J, Cooper J, Harrison J, Paddle J, Pellegrini JAS, Needleman J, Giles J, Camsooksai J, Furneval J, Toms J, Burt K, Simeson K, Williams K, Blenk K, Turner K, Lynch K, Sweet K, Hugill K, Matthews K, Ruas K, Clarkson K, Preller K, Joyce K, Ortiz-Ruiz L, Youds L, Tbaily L, Barrell L, Grimmer L, Soyoral L, Peluso L, Murray L, Niska L, Tonks L, Fasting L, DeCrop L, Brazzi L, Mirabella L, Cooper L, Falcão LF, Everett L, Watters M, Carnahan M, Bourgeois M, Abreu MG, Romano MLP, Botteri M, Melo MFV, Melo MFV, Schultz MJ, Schultz MJ, Faulkner M, Krkusek M, Bahl M, Holliday M, Kol M, Pulletz M, Hollmann MW, Kozlowski M, Dvorscak MB, Jurjevic M, Koopmans M, Morales M, Schaefer M, Brazier M, Harris M, Devile M, Hiesmayr M, Kuiper M, Parris M, Sharman M, Kratochvil M, Ramali M, Dos Santos MC, Bynorth N, Wilson N, Anquez N, Huneke N, Dogan N, Karanovic N, Tarmey N, Carreño N, Fisher N, Lamb N, Venner N, Hollister N, Akgun N, Ekinci O, Boyd O, Pelosi P, Pelosi P, Severgnini P, Severgnini P, Gill P, Raimondo P, Verrastro P, Pulak P, Fitzell P, Dark P, Alzugaray P, Özcan PE, MacNaughton P, Stourac P, Hopkins P, Tuinman PR, Pearson R, Walker R, Santos RSD, Caione R, Matsa R, Oliver R, Jacob R, Howard-Griffin R, Wilde RB, Plant R, Hollands R, Biondi R, Smith R, Smith R, Determann RM, Jaafar R, Avendaño R, Pearse RM, Salt R, Humphries R, Pinto SF, Hemmes SNT, Pearson S, Hendry S, Jaber S, Lakhani S, Beavis S, Moreton S, Prudden S, Thornthwaite S, Spadaro S, Saylan S, Chenna S, Gopal S, James S, Suresh S, Birch S, Skilijic S, Aguirre S, Metherell S, Bell S, Janes S, Wright S, Rose S, Windebank S, Glenn S, Melbourne S, Tyson S, Leaver S, Treschan TA, Treschan TA, Patel T, Simurina T, Sewell TA, Macruz T, Hatton T, Evans T, Goktas U, Poultney U, Buyukkocak U, Linnett V, Oliveira V, Russotto V, Klaric V, Schmid W, Orak Y, Demirtürk Z., Neto, A, Barbas, C, Simonis, F, Artigas-Raventos, A, Canet, J, Determann, R, Anstey, J, Hedenstierna, G, Hemmes, S, Hermans, G, Hiesmayr, M, Hollmann, M, Jaber, S, Martin-Loeches, I, Mills, G, Pearse, R, Putensen, C, Schmid, W, Severgnini, P, Smith, R, Treschan, T, Tschernko, E, Melo, M, Wrigge, H, de Abreu, M, Pelosi, P, Schultz, M, Russotto, V, Intensive Care Medicine, Other departments, and Anesthesiology
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Male ,Pediatrics ,ARDS ,medicine.medical_treatment ,law.invention ,Positive-Pressure Respiration ,0302 clinical medicine ,law ,Risk Factors ,Prevalence ,ventilator–induced lung injury ,Prospective Studies ,Hospital Mortality ,Prospective cohort study ,Tidal volume ,education.field_of_study ,Respiratory Distress Syndrome ,Acute respiratory distress syndrome ,tidal volume ,ARDS, critically ill, ventilation ,Middle Aged ,Intensive care unit ,Intensive Care Units ,Critical Illne ,Female ,Human ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Critical Illness ,Population ,Intensive Care Unit ,Lung injury ,mechanical ventilation ,NO ,03 medical and health sciences ,Intensive care ,medicine ,Acute respiratory distress syndrome, mechanical ventilation, ventilator–induced lung injury, tidal volume, positive end–expiratory pressure ,Humans ,MED/41 - ANESTESIOLOGIA ,education ,Aged ,Mechanical ventilation ,business.industry ,Risk Factor ,Respiratory Distress Syndrome, Adult ,030208 emergency & critical care medicine ,medicine.disease ,Respiration, Artificial ,Mechanical ventilation Acute respiratory failure Acute respiratory distress syndrome ,Prospective Studie ,030228 respiratory system ,Emergency medicine ,positive end–expiratory pressure ,business - Abstract
Background Scant information exists about the epidemiological characteristics and outcome of patients in the intensive care unit (ICU) at risk of acute respiratory distress syndrome (ARDS) and how ventilation is managed in these individuals. We aimed to establish the epidemiological characteristics of patients at risk of ARDS, describe ventilation management in this population, and assess outcomes compared with people at no risk of ARDS. Methods PRoVENT (PRactice of VENTilation in critically ill patients without ARDS at onset of ventilation) is an international, multicentre, prospective study undertaken at 119 ICUs in 16 countries worldwide. All patients aged 18 years or older who were receiving mechanical ventilation in participating ICUs during a 1-week period between January, 2014, and January, 2015, were enrolled into the study. The Lung Injury Prediction Score (LIPS) was used to stratify risk of ARDS, with a score of 4 or higher defining those at risk of ARDS. The primary outcome was the proportion of patients at risk of ARDS. Secondary outcomes included ventilatory management (including tidal volume [VT] expressed as mL/kg predicted bodyweight [PBW], and positive end-expiratory pressure [PEEP] expressed as cm H2O), development of pulmonary complications, and clinical outcomes. The PRoVENT study is registered at ClinicalTrials.gov, NCT01868321. The study has been completed. Findings Of 3023 patients screened for the study, 935 individuals fulfilled the inclusion criteria. Of these critically ill patients, 282 were at risk of ARDS (30%, 95% CI 27â33), representing 0·14 cases per ICU bed over a 1-week period. VTwas similar for patients at risk and not at risk of ARDS (median 7·6 mL/kg PBW [IQR 6·7â9·1] vs 7·9 mL/kg PBW [6·8â9·1]; p=0·346). PEEP was higher in patients at risk of ARDS compared with those not at risk (median 6·0 cm H2O [IQR 5·0â8·0] vs 5·0 cm H2O [5·0â7·0]; p
- Published
- 2016