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1. Pediatric Patients with Eosinophilic Esophagitis and Their Parents Identify Symptoms as the Most Important Treatment Outcome

Author

von Graffenried, Thea, primary, Safroneeva, Ekaterina, additional, Braegger, Christian, additional, Ezri, Jessica, additional, Garzoni, Luca, additional, Giroud Rivier, Alexa, additional, Greuter, Thomas, additional, Köhler, Henrik, additional, McLin, Valerie A., additional, Marx, George, additional, Müller, Pascal, additional, Petit, Laetitia Marie, additional, Schibli, Susanne, additional, Sokollik, Christiane, additional, Tempia-Caliera, Michela, additional, Zwahlen, Marcel, additional, Schoepfer, Alain M., additional, and Nydegger, Andreas, additional

Published
2024
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2. Impact of Overweight and Obesity on Disease Outcome in the Pediatric Swiss Inflammatory Bowel Disease Cohort

Author

von Graffenried, Thea, Schoepfer, Alain M., Rossel, Jean-Benoit, Greuter, Thomas, Safroneeva, Ekaterina, Godat, Sébastien, Henchoz, Sarah, Vavricka, Stephan R., Sokollik, Christiane, Spalinger, Johannes, Braegger, Christian P., Nydegger, Andreas, Abdelrahman, Karim, Ademi, Gentiana, Aepli, Patrick, Thomas, Amman, Anderegg, Claudia, Antonino, Anca-Teodora, Archanioti, Eva, Arrigoni, Eviano, de Jong, Diana Bakker, Balsiger, Bruno, Bastürk, Polat, Bauerfeind, Peter, Becocci, Andrea, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Boldanova, Tujana, Borovicka, Jan, Braegger, Christian P., Brand, Stephan, Brügger, Lukas, Brunner, Simon, Bühr, Patrick, Burnand, Bernard, Burk, Sabine, Burri, Emanuel, Buyse, Sophie, Cao, Dahlia-Thao, Carstens, Ove, Criblez, Dominique H., Cunningham, Sophie, D’Angelo, Fabrizia, de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Drerup, Susan, Egger, Mara, El-Wafa, Ali, Engelmann, Matthias, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Franc, Yannick, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Furlano, Raoul Ivano, Garzoni, Luca, Geyer, Martin, Girard, Laurent, Girardin, Marc, Golay, Delphine, Good, Ignaz, Bigler, Ulrike Graf, Gysi, Beat, Haarer, Johannes, Halama, Marcel, Haldemann, Janine, Heer, Pius, Heimgartner, Benjamin, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hirschi, Claudia, Hruz, Petr, Juillerat, Pascal, Khalid-de Bakker, Carolina, Kayser, Stephan, Keller, Céline, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger, Claudia, Künzler, Patrizia, Kusche, Rachel, Lehmann, Frank Serge, Macpherson, Andrew, Maillard, Michel H., Manz, Michael, Marot, Astrid, Meier, Rémy, Meyenberger, Christa, Meyer, Pamela, Michetti, Pierre, Misselwitz, Benjamin, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müllhaupt, Beat, Musso, Leilla, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Nydegger, Andreas, Obialo, Nicole, Ollo, Diana, Oropesa, Cassandra, Peter, Ulrich, Peternac, Daniel, Petit, Laetitia Marie, Pittet, Valérie, Pohl, Daniel, Porzner, Marc, Preissler, Claudia, Raschle, Nadia, Rentsch, Ronald, Restellini, Alexandre, Restellini, Sophie, Richterich, Jean-Pierre, Ris, Frederic, Risti, Branislav, Ritz, Marc Alain, Rogler, Gerhard, Röhrich, Nina, Rossel, Jean-Benoît, Rueger, Vanessa, Rusticeanu, Monica, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Schluckebier, Dominique, Schmid, Daniela, Schmid, Sybille, Schnegg, Jean-François, Schoepfer, Alain, Seematter, Vivianne, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Senning, Arne, Sokollik, Christiane, Sommer, Joachim, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Staub, Peter, Staudenmann, Dominic, Stenz, Volker, Steuerwald, Michael, Straumann, Alex, Stulz, Andreas, Sulz, Michael, Tatu, Aurora, Tempia-Caliera, Michela, Thorens, Joël, Truninger, Kaspar, Tutuian, Radu, Urfer, Patrick, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vouillamoz, Dominique, Vulliamy, Rachel, Wiesel, Paul, Wiest, Reiner, Wöhrle, Stefanie, Zamora, Samuel, Zander, Silvan, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2022
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3. Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals

Author

Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Keller, Céline, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, Meier, Rémy, Mendanova, Martina, Michetti, Pierre, Misselwitz, Benjamin, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli-Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Rueger, Vanessa, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Scharl, Sylvie, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Suter, Alexandra, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, Zimmermann, Dorothee, Pittet, Valérie E.H., and Simonson, Thomas

Published
2019
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6. Alternativen zu Säuglingsnahrungen auf Kuhmilchproteinbasis

Author

Greber-Platzer, Susanne, Gsöllpointner, Melanie, Haiden, Nadja, Hauer, Almuth Christine, Lanzersdorfer, Roland, Pietschnig, Beate, Schneider, Anna-Maria, Scholl-Bürgi, Sabine, Sperl, Wolfgang, Stenzel, Helga Christine, Weghuber, Daniel, Bührer, Christoph, Ensenauer, Regina, Jochum, Frank, Kalhoff, Hermann, Koletzko, Berthold; https://orcid.org/0000-0002-5345-7165, Lawrenz, Antje Burkhard, Mihatsch, Walter, Posovszky, Carsten; https://orcid.org/0000-0002-9487-8812, Rudloff, Silvia, Braegger, Christian, Fischer-Fumeaux, Céline J, Lauener, Roger; https://orcid.org/0000-0002-8412-606X, Petit, Laetitia-Marie, Greber-Platzer, Susanne, Gsöllpointner, Melanie, Haiden, Nadja, Hauer, Almuth Christine, Lanzersdorfer, Roland, Pietschnig, Beate, Schneider, Anna-Maria, Scholl-Bürgi, Sabine, Sperl, Wolfgang, Stenzel, Helga Christine, Weghuber, Daniel, Bührer, Christoph, Ensenauer, Regina, Jochum, Frank, Kalhoff, Hermann, Koletzko, Berthold; https://orcid.org/0000-0002-5345-7165, Lawrenz, Antje Burkhard, Mihatsch, Walter, Posovszky, Carsten; https://orcid.org/0000-0002-9487-8812, Rudloff, Silvia, Braegger, Christian, Fischer-Fumeaux, Céline J, Lauener, Roger; https://orcid.org/0000-0002-8412-606X, and Petit, Laetitia-Marie

Abstract

Die natürliche Ernährung eines gesunden Säuglings ist das Stillen. Ist Stillen oder die Fütterung von Muttermilch nicht möglich, kann Frauenmilch für die Ernährung des Säuglings erwogen werden, sofern diese aus einer qualifizierten Humanmilchbank stammt. Vom Kauf von Frauenmilch aus dem Internet wird wegen Risiken einer Infektionsübertragung und einer unzureichenden Milchqualität strikt abgeraten. Aufgrund der geringen Verfügbarkeit, der hohen Kosten sowie möglicher Nachteile der Ernährung mit Spendermilch im Vergleich zum Stillen sind industriell gefertigte Säuglingsnahrungen das Mittel der Wahl zur Ernährung des gesunden, reifgeborenen Säuglings, wenn Stillen nicht oder nur partiell möglich ist. Kuhmilchprotein ist die am häufigsten verwendete Eiweißkomponente. Die Nachfrage nach anderen auf Tiermilchen basierten sowie vegetarischen bzw. veganen Alternativen steigt. Im Folgenden werden verschiedene Alternativen bezüglich ihrer Eignung betrachtet. Säuglingsnahrungen auf Basis von Ziegenmilchprotein stellen für gesunde, reifgeborene Säuglinge eine zugelassene und geeignete Alternative zu kuhmilchproteinbasierten Säuglingsnahrungen dar. Für Säuglingsnahrungen aus anderen Tiermilchen (z. B. Kamel‑, Schaf‑, Pferde- oder Büffelmilch) sind keine belastbaren Daten zu Eignung und Sicherheit bekannt, und sie sind in der Europäischen Union nicht zugelassen. Säuglingsnahrungen auf der Grundlage von Sojaproteinisolaten sind in der Europäischen Union zugelassen. Sie werden für die allgemeine Verwendung im 1. Lebenshalbjahr durch die Ernährungskommission nicht empfohlen, insbesondere weil potenziell nachteilige Effekte von enthaltenen Isoflavonen nicht ausgeschlossen werden können. Ab der Geburt und in den ersten Lebensmonaten sollte die Gabe von Sojanahrungen auf Indikationen wie eine bestehende Galaktosämie, die sehr seltene kongenitale Laktoseintoleranz sowie bei familiärem Wunsch nach veganer Ernährungsweise und aus anderen weltanschaulichen Gründen begrenzt werden. Im 2. Le

Published
2023

7. The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

Author

Madanchi, Matiar, Fagagnini, Stefania, Fournier, Nicolas, Biedermann, Luc, Zeitz, Jonas, Battegay, Edouard, Zimmerli, Lukas, Vavricka, Stephan R, Rogler, Gerhard, Scharl, Michael, Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Belli, Dominique, Bengoa, José M, Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P, Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H, Saussure, Philippe de, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El-Wafa, Ali, Engelmann, Matthias, Ezri, Jessica, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot-Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Brondolo, Vera Kessler, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger-Grübel, Claudia, Kullak-Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H, Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger-Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli-Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean-Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean-Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean-François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian-Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann-Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Känel, Roland Von, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2018
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11. Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohnʼs disease

Author

Lang, B. M., Biedermann, L., van Haaften, W. T., de Vallière, C., Schuurmans, M., Begré, S., Zeitz, J., Scharl, M., Turina, M., Greuter, T., Schreiner, P., Heinrich, H., Kuntzen, T., Vavricka, S. R., Rogler, G., Beerenwinkel, N., Misselwitz, B., Anderegg, Claudia, Bauerfeind, Peter, Beglinger, Christoph, Begré, Stefan, Bengoa, José M., Biedermann, Luc, Bigler, Beat, Binek, Janek, Blattmann, Mirjam, Boehm, Stephan, Borovicka, Jan, Braegger, Christian P., Brunner, Nora, Bühr, Patrick, Burnand, Bernard, Burri, Emanuel, Buyse, Sophie, Cremer, Matthias, Criblez, Dominique H., de Saussure, Philippe, Degen, Lukas, Delarive, Joakim, Doerig, Christopher, Dora, Barbara, Dorta, Gian, Egger, Mara, Ehmann, Tobias, El‐Wafa, Ali, Engelmann, Matthias, Ezri, a, Felley, Christian, Fliegner, Markus, Fournier, Nicolas, Fraga, Montserrat, Frei, Pascal, Frei, Remus, Fried, Michael, Froehlich, Florian, Funk, Christian, Furlano, Raoul Ivano, Gallot‐Lavallée, Suzanne, Geyer, Martin, Girardin, Marc, Golay, Delphine, Grandinetti, Tanja, Gysi, Beat, Haack, Horst, Haarer, Johannes, Helbling, Beat, Hengstler, Peter, Herzog, Denise, Hess, Cyrill, Heyland, Klaas, Hinterleitner, Thomas, Hiroz, Philippe, Hirschi, Claudia, Hruz, Petr, Iwata, Rika, Jost, Res, Juillerat, Pascal, Kessler Brondolo, Vera, Knellwolf, Christina, Knoblauch, Christoph, Köhler, Henrik, Koller, Rebekka, Krieger‐Grübel, Claudia, Kullak‐Ublick, Gerd, Künzler, Patrizia, Landolt, Markus, Lange, Rupprecht, Lehmann, Frank Serge, Macpherson, Andrew, Maerten, Philippe, Maillard, Michel H., Manser, Christine, Manz, Michael, Marbet, Urs, Marx, George, Matter, Christoph, McLin, Valérie, Meier, Rémy, Mendanova, Martina, Meyenberger, Christa, Michetti, Pierre, Misselwitz, Benjamin, Moradpour, Darius, Morell, Bernhard, Mosler, Patrick, Mottet, Christian, Müller, Christoph, Müller, Pascal, Müllhaupt, Beat, Münger‐Beyeler, Claudia, Musso, Leilla, Nagy, Andreas, Neagu, Michaela, Nichita, Cristina, Niess, Jan, Noël, Natacha, Nydegger, Andreas, Obialo, Nicole, Oneta, Carl, Oropesa, Cassandra, Peter, Ueli, Peternac, Daniel, Petit, Laetitia Marie, Piccoli‐Gfeller, Franziska, Pilz, Julia Beatrice, Pittet, Valérie, Raschle, Nadia, Rentsch, Ronald, Restellini, Sophie, Richterich, Jean‐Pierre, Rihs, Sylvia, Ritz, Marc Alain, Roduit, Jocelyn, Rogler, Daniela, Rogler, Gerhard, Rossel, Jean‐Benoît, Sagmeister, Markus, Saner, Gaby, Sauter, Bernhard, Sawatzki, Mikael, Schäppi, Michela, Scharl, Michael, Schelling, Martin, Schibli, Susanne, Schlauri, Hugo, Uebelhart, Sybille Schmid, Schnegg, Jean‐François, Schoepfer, Alain, Seibold, Frank, Seirafi, Mariam, Semadeni, Gian‐Marco, Semela, David, Senning, Arne, Sidler, Marc, Sokollik, Christiane, Spalinger, Johannes, Spangenberger, Holger, Stadler, Philippe, Steuerwald, Michael, Straumann, Alex, Straumann‐Funk, Bigna, Sulz, Michael, Thorens, Joël, Tiedemann, Sarah, Tutuian, Radu, Vavricka, Stephan, Viani, Francesco, Vögtlin, Jürg, Von Känel, Roland, Vonlaufen, Alain, Vouillamoz, Dominique, Vulliamy, Rachel, Wermuth, Jürg, Werner, Helene, Wiesel, Paul, Wiest, Reiner, Wylie, Tina, Zeitz, Jonas, and Zimmermann, Dorothee

Published
2018
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15. Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications

Author

Herzog, Denise, Fournier, Nicolas, Buehr, Patrick, Rueger, Vanessa, Koller, Rebekka, Heyland, Klaas, Nydegger, Andreas, Spalinger, Johannes, Schibli, Susanne, Petit, Laetitia-Marie, Braegger, Christian P, Swiss IBD Cohort Study Group, University of Zurich, and Braegger, Christian P

Subjects
Male, Pediatrics, Time Factors, Cholangitis, Severity of Illness Index, Inflammatory bowel disease, Switzerland/epidemiology, 0302 clinical medicine, Crohn Disease, Risk Factors, Prevalence, Prospective Studies, Registries, Age of Onset, Child, 610 Medicine & health, Prospective cohort study, Stomatitis, Crohn Disease/diagnosis/epidemiology/therapy, ddc:618, Gastroenterology, Anemia, Colitis, Prognosis, Metabolic/epidemiology, Arthralgia, Ankylosing/epidemiology, 030220 oncology & carcinogenesis, Disease Progression, Female, Stomatitis, Aphthous, 030211 gastroenterology & hepatology, Sclerosing/epidemiology, Bone Diseases, Ulcerative/diagnosis/epidemiology/therapy, Switzerland, Adult, medicine.medical_specialty, Anemia/epidemiology, Adolescent, Cholangitis, Sclerosing, 03 medical and health sciences, Severity of illness, medicine, Humans, Spondylitis, Ankylosing, 2715 Gastroenterology, Spondylitis, Retrospective Studies, Aphthous/epidemiology, Hepatology, business.industry, Retrospective cohort study, medicine.disease, Arthralgia/epidemiology, Bone Diseases, Metabolic, 10036 Medical Clinic, Colitis, Ulcerative, 2721 Hepatology, Age of onset, business
Abstract

INTRODUCTION A small but increasing number of patients with inflammatory bowel disease are diagnosed during childhood or adolescence, and disease distribution and severity at onset vary according to the age at diagnosis. Clinical factors present at the time of diagnosis can be predictive of the disease course. AIM The aim of this study was to characterize disease behavior and the cumulative complications and extraintestinal manifestations 10 years after the diagnosis and to assess their association with age at diagnosis. PATIENTS AND METHODS Data of patients participating with the Swiss IBD cohort study registry, a disease duration of 10 years and a complete data set were analyzed. The outcome was defined as the cumulative change of disease behavior, the occurrence of extra-intestinal manifestations or complications, and the necessity for medical or surgical interventions. RESULTS A total of 481 patients with Crohn's disease (CD) and 386 patients with ulcerative colitis (UC), grouped according to disease onset before 10, 17, 40, or after 40 years of age, were analyzed. Despite differences in sex, initial disease location, and smoking habits, at 10 years after the diagnosis, no difference was found regarding disease behavior in CD or regarding progression of disease extension in UC. Similarly, no age-of-onset-dependent cumulative need for medical or surgical therapies was found. However, higher rates of anemia and lower rates of arthralgia and osteopenia were found in both pediatric-onset CD and UC, and a tendency toward higher rates of stomatitis in pediatric-onset CD, and of primary sclerosing cholangitis and ankylosing spondylitis in pediatric-onset UC. CONCLUSION After 10 years of disease evolution, age at disease onset is not anymore associated with disease behavior but only with a small difference in the occurrence of specific extraintestinal manifestations and complications.

Published
2018
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20. E-Learning Training to Improve Pediatric Parenteral Nutrition Practice: A Pilot Study in Two University Hospitals.

Author

Petit, Laetitia‐Marie, Le Pape, Pauline, Delestras, Stephanie, Nguyen, Christina, Marchand, Valerie, Belli, Dominique, Bonnabry, Pascal, Bajwa, Nadia, Fonzo‐Christe, Caroline, Petit, Laetitia-Marie, and Fonzo-Christe, Caroline

Subjects
CHILD nutrition, PARENTERAL feeding, UNIVERSITY hospitals, PILOT projects, CHILDREN'S hospitals, SHORT bowel syndrome, RESEARCH, ACADEMIC medical centers, COMPUTER assisted instruction, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, BLIND experiment
Abstract

Background: Education and training may improve the prescription of pediatric parenteral nutrition. The aim was to evaluate the impact of an e-learning method on parenteral nutrition prescription skills among pediatric residents in 2 pediatric hospitals.Methods: A randomized double-blind control study was conducted over a 9-month period among pediatric residents in HOSP1, Geneva, Switzerland, where physicians prescribe parenteral nutrition directly, and in HOSP2, Montreal, Canada, where physicians prescribe only occasionally because clinical pharmacists are devoted to this activity. The intervention consisted of an e-learning session about key issues of parenteral nutrition. Physician parenteral nutrition knowledge was evaluated with a standardized questionnaire based on clinical cases before and after the e-learning in the intervention groups; in the control groups, only the 2 tests were conducted. In HOSP1, participants also underwent iterative tests every 2 months to measure the retention of knowledge.Results: Sixty-five physicians participated. Initial knowledge scores were higher in HOSP1 (pretest scores 180 ± 29 vs 133 ± 24, p < 0.001). Overall, there was no significant difference in the impact of the e-learning intervention between the control and e-learning groups (p > 0.05). A significant knowledge improvement was observed in HOSP2 in the e-learning group (p = 0.033). Iterative tests in HOSP1 showed persistence of knowledge without significant differences between the groups. E-learning satisfaction among the participants was outstanding (100%).Conclusion: E-learning seems to be an effective method for teaching parenteral nutrition among pediatric residents and fellows at the beginning of the training. High satisfaction with this teaching method was observed in this study. [ABSTRACT FROM AUTHOR]

Published
2020
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23. Preformed and de novo DSA are associated with T‐cell–mediated rejection in pediatric liver transplant recipients requiring clinically indicated liver biopsy

Author

Schluckebier, Dominique, primary, Cousin, Vladimir L., additional, Petit, Laetitia‐Marie, additional, Belli, Dominique, additional, Wildhaber, Barbara, additional, Rougemont, Anne‐Laure, additional, Villard, Jean, additional, Ferrari‐Lacraz, Sylvie, additional, and McLin, Valérie A., additional

Published
2019
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24. Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals

Author

Pittet, Valérie E.H., primary, Maillard, Michel H., additional, Simonson, Thomas, additional, Fournier, Nicolas, additional, Rogler, Gerhard, additional, Michetti, Pierre, additional, Anderegg, Claudia, additional, Bauerfeind, Peter, additional, Beglinger, Christoph, additional, Begré, Stefan, additional, Belli, Dominique, additional, Bengoa, José M., additional, Biedermann, Luc, additional, Bigler, Beat, additional, Binek, Janek, additional, Blattmann, Mirjam, additional, Boehm, Stephan, additional, Borovicka, Jan, additional, Braegger, Christian P., additional, Brunner, Nora, additional, Bühr, Patrick, additional, Burnand, Bernard, additional, Burri, Emanuel, additional, Buyse, Sophie, additional, Cremer, Matthias, additional, Criblez, Dominique H., additional, de Saussure, Philippe, additional, Degen, Lukas, additional, Delarive, Joakim, additional, Doerig, Christopher, additional, Dora, Barbara, additional, Dorta, Gian, additional, Egger, Mara, additional, Ehmann, Tobias, additional, El-Wafa, Ali, additional, Engelmann, Matthias, additional, Ezri, Jessica, additional, Felley, Christian, additional, Fliegner, Markus, additional, Fraga, Montserrat, additional, Frei, Pascal, additional, Frei, Remus, additional, Fried, Michael, additional, Froehlich, Florian, additional, Funk, Christian, additional, Furlano, Raoul Ivano, additional, Gallot-Lavallée, Suzanne, additional, Geyer, Martin, additional, Girardin, Marc, additional, Golay, Delphine, additional, Grandinetti, Tanja, additional, Gysi, Beat, additional, Haack, Horst, additional, Haarer, Johannes, additional, Helbling, Beat, additional, Hengstler, Peter, additional, Herzog, Denise, additional, Hess, Cyrill, additional, Heyland, Klaas, additional, Hinterleitner, Thomas, additional, Hiroz, Philippe, additional, Hirschi, Claudia, additional, Hruz, Petr, additional, Iwata, Rika, additional, Jost, Res, additional, Juillerat, Pascal, additional, Keller, Céline, additional, Knellwolf, Christina, additional, Knoblauch, Christoph, additional, Köhler, Henrik, additional, Koller, Rebekka, additional, Krieger-Grübel, Claudia, additional, Kullak-Ublick, Gerd, additional, Künzler, Patrizia, additional, Landolt, Markus, additional, Lange, Rupprecht, additional, Lehmann, Frank Serge, additional, Macpherson, Andrew, additional, Maerten, Philippe, additional, Manser, Christine, additional, Manz, Michael, additional, Marbet, Urs, additional, Marx, George, additional, Matter, Christoph, additional, Meier, Rémy, additional, Mendanova, Martina, additional, Misselwitz, Benjamin, additional, Morell, Bernhard, additional, Mosler, Patrick, additional, Mottet, Christian, additional, Müller, Christoph, additional, Müller, Pascal, additional, Müllhaupt, Beat, additional, Münger-Beyeler, Claudia, additional, Musso, Leilla, additional, Nagy, Andreas, additional, Neagu, Michaela, additional, Nichita, Cristina, additional, Niess, Jan, additional, Nydegger, Andreas, additional, Obialo, Nicole, additional, Oneta, Carl, additional, Oropesa, Cassandra, additional, Peter, Ueli, additional, Peternac, Daniel, additional, Petit, Laetitia Marie, additional, Piccoli-Gfeller, Franziska, additional, Pilz, Julia Beatrice, additional, Pittet, Valérie, additional, Raschle, Nadia, additional, Rentsch, Ronald, additional, Restellini, Sophie, additional, Richterich, Jean-Pierre, additional, Rihs, Sylvia, additional, Ritz, Marc Alain, additional, Roduit, Jocelyn, additional, Rogler, Daniela, additional, Rossel, Jean-Benoît, additional, Rueger, Vanessa, additional, Saner, Gaby, additional, Sauter, Bernhard, additional, Sawatzki, Mikael, additional, Schäppi, Michela, additional, Scharl, Michael, additional, Scharl, Sylvie, additional, Schelling, Martin, additional, Schibli, Susanne, additional, Schlauri, Hugo, additional, Uebelhart, Sybille Schmid, additional, Schnegg, Jean-François, additional, Schoepfer, Alain, additional, Seibold, Frank, additional, Seirafi, Mariam, additional, Semadeni, Gian-Marco, additional, Semela, David, additional, Senning, Arne, additional, Sidler, Marc, additional, Sokollik, Christiane, additional, Spalinger, Johannes, additional, Spangenberger, Holger, additional, Stadler, Philippe, additional, Steuerwald, Michael, additional, Straumann, Alex, additional, Straumann-Funk, Bigna, additional, Sulz, Michael, additional, Suter, Alexandra, additional, Thorens, Joël, additional, Tiedemann, Sarah, additional, Tutuian, Radu, additional, Vavricka, Stephan, additional, Viani, Francesco, additional, Vögtlin, Jürg, additional, Von Känel, Roland, additional, Vonlaufen, Alain, additional, Vouillamoz, Dominique, additional, Vulliamy, Rachel, additional, Wermuth, Jürg, additional, Werner, Helene, additional, Wiesel, Paul, additional, Wiest, Reiner, additional, Wylie, Tina, additional, Zeitz, Jonas, additional, and Zimmermann, Dorothee, additional

Published
2019
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25. Food protein-induced enterocolitis syndrome – a review of the literature with focus on clinical management

Author

Michelet,Marine, Schluckebier,Dominique, Petit,Laetitia-Marie, and Caubet,Jean-Christoph

Subjects
Journal of Asthma and Allergy
Abstract

Marine Michelet,1,* Dominique Schluckebier,2,* Laetitia-Marie Petit,2 Jean-Christoph Caubet3 1Children Hospital, Pediatric Allergology Unit CHU Toulouse, Toulouse, France; 2Geneva University Hospitals, Pediatric Gastroenterology Unit, 3Geneva University Hospitals, Pediatric Allergology Unit, Geneva, Switzerland *These authors contributed equally to this work Abstract: Food protein-induced enterocolitis syndrome (FPIES) is a potentially severe presentation of non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) with heterogeneous clinical manifestations. Acute FPIES is typically characterized by profuse vomiting and lethargy, occurring classically 1–4 hours after ingestion of the offending food. When continuously exposed to the incriminated food, a chronic form has been described with persistent vomiting, diarrhea, and/or failure to thrive. Although affecting mainly infants, FPIES has also been described in adults. Although FPIES is actually one of the most actively studied non-IgE-GI-FAs, epidemiologic data are lacking, and estimation of the prevalence is based on a limited number of prospective studies. The exact pathomechanisms of FPIES remain not well defined, but recent data suggest involvement of neutrophils and mast cells, in addition to T cells. There is a wide range of food allergens that can cause FPIES with some geographical variations. The most frequently incriminated foods are cow milk, soy, and grains in Europe and USA. Furthermore, FPIES can be induced by foods usually considered as hypoallergenic, such as chicken, potatoes or rice. The diagnosis relies currently on typical clinical manifestations, resolving after the elimination of the offending food from the infant’s/child’s diet and/or an oral food challenge (OFC). The prognosis is usually favorable, with the vast majority of the case resolving before 5 years of age. Usually, assessment of tolerance acquisition by OFC is proposed every 12–18 months. Of note, a switch to an IgE-mediated FA is possible and has been suggested to be associated with a more severe phenotype. Avoiding the offending food requires education of the family of the affected child. A multidisciplinary approach including ideally allergists, gastroenterologists, dieticians, specialized nurses, and caregivers is often useful to optimize the management of these patients, that might be difficult. Keywords: FPIES, FPIES management, FPIES diagnosis, non-IgE-mediated gastrointestinal food allergy, cow milk

Published
2017

29. Antibody-mediated rejection in pediatric small bowel transplantation: Capillaritis is a major determinant of C4d positivity in intestinal transplant biopsies

Author

Rabant, Marion, primary, Racapé, Maud, additional, Petit, Laetitia-Marie, additional, Taupin, Jean Luc, additional, Aubert, Olivier, additional, Bruneau, Julie, additional, Barbet, Patrick, additional, Goulet, Olivier, additional, Chardot, Christophe, additional, Suberbielle, Caroline, additional, Lacaille, Florence, additional, Canioni, Danielle, additional, and Duong Van Huyen, Jean-Paul, additional

Published
2018
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30. Combined Pancreatic Islet-Lung-Liver Transplantation in a Pediatric Patient with Cystic Fibrosis-Related Diabetes

Author

Klee, Philippe, primary, Dirlewanger, Mirjam, additional, Lavallard, Vanessa, additional, McLin, Valerie A., additional, Mornand, Anne, additional, Pernin, Nadine, additional, Petit, Laetitia-Marie, additional, Soccal, Paola M., additional, Wildhaber, Barbara E., additional, Zumsteg, Urs, additional, Blouin, Jean-Louis, additional, Berney, Thierry, additional, and Schwitzgebel, Valerie M., additional

Published
2018
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31. Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease: Prevalence, Presentation, and Anti-TNF Treatment

Author

Greuter, Thomas, primary, Bertoldo, Fabio, additional, Rechner, Roman, additional, Straumann, Alex, additional, Biedermann, Luc, additional, Zeitz, Jonas, additional, Misselwitz, Benjamin, additional, Scharl, Michael, additional, Rogler, Gerhard, additional, Safroneeva, Ekaterina, additional, Ali, Raja A.R., additional, Braegger, Christian, additional, Heyland, Klaas, additional, Mueller, Pascal, additional, Nydegger, Andreas, additional, Petit, Laetitia-Marie, additional, Schibli, Susanne, additional, Furlano, Raoul I., additional, Spalinger, Johannes, additional, Schäppi, Michela, additional, Zamora, Samuel, additional, Froehlich, Florian, additional, Herzog, Denise, additional, Schoepfer, Alain M., additional, and Vavricka, Stephan R., additional

Published
2017
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33. Refinement of Histological Criteria of Acute Humoral Rejection in Small Bowel Transplantation.

Author

Rabant, Marion, primary, Racapé, Maud, additional, Aubert, Olivier, additional, Petit, Laetitia-Marie, additional, Bruneau, Julie, additional, Barbet, Patrick, additional, Goulet, Olivier, additional, Chardot, Christophe, additional, Taupin, Jean Luc, additional, Lacaille, Florence, additional, Canioni, Danielle, additional, and Van Huyen, Jean-Paul Duong, additional

Published
2017
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35. Prevalence and Predictive Factors of Histopathological Complications in Children with Esophageal Atresia.

Author

Petit, Laetitia-Marie, Righini-Grunder, Franziska, Ezri, Jessica, Jantchou, Prevost, Aspirot, Ann, Soglio, Dorothée Dal, and Faure, Christophe

Subjects
*H2 receptor antagonists, *EOSINOPHILIC esophagitis, *REGRESSION analysis, *CHI-squared test, *URETHROPLASTY, *TRACHEAL fistula, *DISEASE progression, *DIGESTIVE system endoscopic surgery, *SURGICAL complications, *PROTON pump inhibitors, *BARRETT'S esophagus, *LANSOPRAZOLE, *ESOPHAGUS diseases, *PROPORTIONAL hazards models, *LONGITUDINAL method, *DISEASE complications, ESOPHAGEAL atresia
Abstract

Objectives:  Endoscopic follow-up after esophageal atresia (EA) tracheoesophageal fistula (TEF) repair is recommended to detect esophageal histopathological complications. We investigated the prevalence of histopathologically proven esophageal complications (peptic esophagitis, gastric metaplasia, and eosinophilic esophagitis) and assessed the predictors of these complications in children with EA-TEF.Materials and Methods:  This is a prospective longitudinal cohort study performed between September 2005 and December 2014 comprising 77 children with EA-TEF followed-up until February 2017. Univariate analysis was performed using the Wilcoxon's rank-sum test for continuous variables and the Pearson's chi-square test for categorical variables. Multivariable analysis was performed using a Cox regression hazard model. The association between clinical factors and histopathologically proven complications was estimated using a Cox regression hazard model with time until the appearance of complications as the time scale.Results:  All 77 children received proton pump inhibitors (PPIs) (n = 73) or H2 receptor antagonists (H2RA). A total of 252 endoscopies were performed in 73 children (median 2.6/child, range: 1-29). Median age at study completion was 4.9 years (range: 2.3-11.5 years). Histopathologically proven complications occurred in 38 children (52%): peptic esophagitis (n = 32, 44%), eosinophilic esophagitis (n = 15, 21%), and gastric metaplasia (n = 9, 12%). A total of 82% patients were on PPI or H2RA at the time of diagnosis of histological complication. Multivariable Cox regression analysis showed that patients with recurrent anastomotic strictures (>3 dilations) had a higher risk of occurrence of histopathologically proven complications over time (hazard ratio: 3.11, 95% confidence interval [CI]: 1.53-6.34). On univariate analysis, the result of the first endoscopy was not associated with the occurrence of histopathologically proven complications (odds ratio: 0.8, 95% CI: 0.16-3.95).Conclusion:  Histopathologically proven complications with potential long-term consequences occurred in approximately 50% of children after EA-TEF repair. A history of recurrent anastomotic strictures is associated with the occurrence of these complications. The result of the first endoscopy does not predict the histopathological outcome. Children with EA-TEF warrant close and systematic long-term follow-up at specialized multidisciplinary clinics with endoscopic evaluation. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Extraintestinal manifestations of pediatric inflammatory bowel disease: prevalence, presentation and anti-TNF treatment

Author

Greuter, Thomas, Bertoldo, Fabio, Rechner, Roman, Straumann, Alex, Biedermann, Luc, Zeitz, Jonas, Misselwitz, Benjamin, Scharl, Michael, Rogler, Gerhard, Safroneeva, Ekaterina, Ali, Raja A R, Braegger, Christian, Heyland, Klaas, Mueller, Pascal, Nydegger, Andreas, Petit, Laetitia-Marie, Schibli, Susanne, Furlano, Raoul I, Spalinger, Johannes, Schäppi, Michela, Zamora, Samuel, Froehlich, Florian, Herzog, Denise, Schoepfer, Alain M, Vavricka, Stephan R, Swiss IBD Cohort Study Group, Greuter, Thomas, Bertoldo, Fabio, Rechner, Roman, Straumann, Alex, Biedermann, Luc, Zeitz, Jonas, Misselwitz, Benjamin, Scharl, Michael, Rogler, Gerhard, Safroneeva, Ekaterina, Ali, Raja A R, Braegger, Christian, Heyland, Klaas, Mueller, Pascal, Nydegger, Andreas, Petit, Laetitia-Marie, Schibli, Susanne, Furlano, Raoul I, Spalinger, Johannes, Schäppi, Michela, Zamora, Samuel, Froehlich, Florian, Herzog, Denise, Schoepfer, Alain M, Vavricka, Stephan R, and Swiss IBD Cohort Study Group

Abstract

BACKGROUND There is a paucity of data on extraintestinal manifestations (EIM) and their treatment in pediatric patients with inflammatory bowel disease (IBD). METHODS Since 2008, the Pediatric Swiss IBD Cohort Study has collected data on the pediatric IBD population in Switzerland. Data on 329 patients were analyzed retrospectively. RESULTS 55 patients (16.7%) suffered from 1-4 EIM (39 Crohn's disease, 12 ulcerative colitis and 4 IBD-Unclassified (IBD-U) patients). At IBD onset, presence of EIM was more frequent than in the adult population (8.5% vs. 5.0%, p = 0.014). EIM were more frequent in CD when compared to UC/IBD-U (22.5 vs. 10.3%, p = 0.003). The most prevalent EIM were peripheral arthritis (26/329, 7.9%) and aphthous stomatitis (24/329, 7.3%). 27.6% of all EIM appeared before IBD diagnosis. Median time between IBD diagnosis and occurrence of first EIM was 1 month (-37.5-149.0). 31 of the 55 patients (56.4%) were treated with one or more anti-TNF agents. IBD patients with EIM were more likely to be treated with anti-TNF compared to those without (56.4% vs. 35.0%, p = 0.003). Response rates to anti-TNF depended on underlying EIM and were best for peripheral arthritis (61.5%) and uveitis (66.7%). CONCLUSIONS In a cohort of pediatric IBD patients, EIM were frequently encountered. In up to 30%, EIM appeared before IBD diagnosis. Knowledge of these findings might translate into an increased awareness of underlying IBD, thereby decreasing diagnostic delay. Anti- TNF for the treatment of certain EIM is effective although a substantial proportion of new EIM might present despite ongoing anti-TNF therapy.

Published
2017

38. A new mutation in the C‐terminal end of <italic>TTC37</italic> leading to a mild form of syndromic diarrhea/tricho‐hepato‐enteric syndrome in seven patients from two families.

Author

Fabre, Alexandre, Petit, Laetitia‐Marie, Hansen, Lars F., Wewer, Anne V., Esteve, Clothilde, Chaix, Charlène, Bourgeois, Patrice, Badens, Catherine, and Paerregaard, Anders

Abstract

Syndromic diarrhea/tricho‐hepato‐enteric syndrome (SD/THE) is a rare congenital enteropathy with seven main clinical features: intractable diarrhea of infancy, hair abnormalities, intrauterine growth restriction (IUGR), facial dysmorphism, immune dysfunction, and liver and skin abnormalities. SD/THE is caused by mutations in TTC37 or SKIV2L, two genes encoding components of the human SKI complex. To date, approximately 50 SD/THE patients have been described with a wide spectrum of mutations, and only one recurrent mutation has been identified in independent families. We present a detailed description of seven patients of Turkish origin with the same new mutation in TTC37: c.4572 G>A p.(Trp1524X). All seven patients were homozygous for this mutation and presented the typical clinical features of SD/THE, but with a milder presentation than usual. All seven patients were alive at the last follow‐up. Four out of seven patients had no IUGR, and four patients never required parenteral nutrition. All patients presented a better growth rate than previously described in patients with SD/THE, with 4/7 above the 3rd percentile. The mutation is localized only forty amino acids from the end of TTC37, and as TTC37 is longer than the yeast SKI3, it is possible that a truncated protein is expressed and plays a reduced role in the SKI complex. [ABSTRACT FROM AUTHOR]

Published
2018
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40. Preformed and de novo DSA are associated with T‐cell–mediated rejection in pediatric liver transplant recipients requiring clinically indicated liver biopsy.

Author

Schluckebier, Dominique, Cousin, Vladimir L., Petit, Laetitia‐Marie, Belli, Dominique, Wildhaber, Barbara, Rougemont, Anne‐Laure, Villard, Jean, Ferrari‐Lacraz, Sylvie, and McLin, Valérie A.

Subjects
LIVER biopsy, LIVER transplantation
Abstract

Despite growing interest about the impact of donor‐specific HLA antibodies (DSA) in LT limited data are available for pediatric recipients. Our aim was to perform a retrospective single‐center chart review of children (0‐16 years) having undergone LT between January 1, 2005 and December 31, 2017, to characterize DSA, to identify factors associated with the development of de novo DSA, and to analyze potential associations with the diagnosis of TCMR. Information on patient‐ and donor‐characteristics and LB reports were analyzed retrospectively. Serum obtained before LT and at LB was analyzed for presence of recipient HLA antibody using Luminex® technology. MFI > 1000 was considered positive. In 63 pediatric LT recipients with a median follow‐up of 72 months, the overall prevalence of de novo DSA was 60.3%. Most were directed against class II antigens (33/38, 86.8%). Preformed DSA were present in 30% of patients. Twenty‐eight (28/63) patients (44.4%) presented at least one episode of TCMR, mostly (12/28, 43%) moderate (Banff 6‐7). De novo DSA were significantly more frequent in patients with TCMR than in patients without (75% vs 48.6%, P =.03), and patients with preformed and de novo DSA had a significantly higher rate of TCMR than patients without any DSA (66.7% vs 20%, P =.02). Neither preformed DSA nor de novo DSA were associated with frequency or severity of TCMR. Recipients with lower weight at LT developed de novo DSA more frequently (P =.04). De novo DSA were highly prevalent in pediatric LT recipients. Although associated with the development of TCMR, they did not appear to impact the frequency or severity of TCMR or graft survival. Instead, de novo DSA may suggest a state of insufficient IS. [ABSTRACT FROM AUTHOR]

Published
2020
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41. [Digestive and nutritional problems of children with cerebral palsy].

Author

Von Graffenried T, Gay G, Bianchi N, Nydegger A, and Petit LM

Subjects
Child, Gastrostomy adverse effects, Humans, Nutritional Status, Cerebral Palsy complications, Cerebral Palsy therapy, Deglutition Disorders etiology, Deglutition Disorders therapy, Malnutrition complications, Nutrition Disorders complications
Abstract

Digestive and nutritional problems of children with cerebral palsy put them at risk of malnutrition. Identification of these problems through measurements of weight, height, and body composition is essential. Feeding difficulties may be caused by a combination of oral and digestive problems, such as swallowing difficulties, gastroesophageal reflux, and constipation. If oral feeding is difficult or unsafe, a nasogastric tube or gastrostomy may be necessary. Once the feeding regimen has been established, energy needs must be assessed on an individual basis. This nutritional management involves a multidisciplinary team of health care professionals, the child, and the family., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.

Published
2022
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42. [Vegan diet in children : what potential deficits to monitor ?]

Author

Petit LM, Nydegger A, and Müller P

Subjects
Adult, Child, Diet, Female, Humans, Pregnancy, Diet, Vegan, Diet, Vegetarian
Abstract

The vegan diet, although beneficial for adults in the prevention of metabolic diseases, raises questions about its benefits for a growing child : adequate caloric and protein intake, quality of essential amino acids, presence of essential fatty acids, inhibition of absorption of trace elements (including iodine, iron and zinc) and supply of various vitamins. Whereas vegan food is vitamin B12 deprived, the biggest challenge remains the vitamin B12 substitution in pregnant women, breastfeeding mothers and children at any age. Specific management by pediatricians using dietetic support and blood analyzes are required for children under vegan diet with respect of moral and ethical values related to this lifestyle choice., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.

Published
2019

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