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Upotreba biljnih preparata kao što su etarska ulja, za različite indikacije u veterinarskoj medicini predstavlja veoma aktuelno i perspektivno polje. U tom kontekstu, najčešće se ispituju i dokazuju antibakterijsko, antifungalno i antiparazitsko, ali i mnoga druga lekovita dejstva ovih preparata. Zbog toga se etarska ulja sve više koriste za različite namene, kao što su prevencija dijareje prasadi ili tretiranje kokcidioze živine. Međutim, usled njihove nestabilne prirode i sklonosti ka isparavanju može doći do degradacije i delimične inaktivacije njihovih aktivnih sastojaka u organizmu, što dovodi do ograničene efikasnosti etarskih ulja nakon primene in vivo. Potencijalno rešenje za ovaj problem, mnogi istraživači vide u inovativnim tehnikama inkapsulacije. One predstavljaju postupak zaštite aktivnih komponenti, fizičkim ili hemijskim procesima, pri čemu se formira zaštitni omotač. Zbog toga su ove tehnike emulzifikacije i nanotehnologije našle primenu u različitim granama (industrija hrane, farmacija), a mogle bi biti veoma korisne i kada je u pitanju primena etarskih ulja. Naime, inkapsulacijom se smanjuje interakcija aktivnih supstanci sa različitim faktorima kao i brzina isparavanja, čime bi se mogla umanjiti inaktivacija sastojaka etarskih ulja, povećati bioraspoloživost, a samim tim i efikasnost. Ovo je posebno značajno za primenu protiv bakterija i endoparazita u gastrointestinalnom traktu. Primenom ovih tehnika se omogućava i kontrolisano oslobađanje aktivnih supstanci, što takođe može biti značajno prilikom pojedinih vidova primene kao što je antiektoparazitska. Na kraju, inkapsulacijom se povećava jednostavnost rukovanja aktivnim supstancama, ali i umanjuje neprijatan miris i ukus, što je veoma bitno prilikom primene etarskih ulja u hrani za životinje. Iz svega navedenog se može zaključiti da tehnike inkapsulacije imaju višestruki značaj kada je u pitanju primena etarskih ulja u veterinarskoj praksi, omogućavajući jednostavniju, praktičniju i efikasniju a, The use of herbal preparations such as essential oils for various indications in veterinary medicine presents a modern and promising field. Within that context, antibacterial, antifungal and antiparasitic, as well as many other medicinal effects of these substances are most often examined. For that reason, essential oils are increasingly used for different purposes, such as prevention of diarrhoea in piglets or coccidiosis treatment in poultry. However, their unstable and volatile nature may lead to degradation and partial deactivation of their active ingredients in the organism after some in vivo applications. As a potential solution for this problem, many researchers consider innovative encapsulation techniques. They represent the process of protecting the active components by physical or chemical processes, whereby a protective coating is formed. Therefore, these techniques such as emulsification or nanotechnology have found application in various branches (food industry, pharmacy) and could be very useful for the application of essential oils. Namely, encapsulation reduces the interaction of active substances with various factors as well as the rate of evaporation, which could reduce the deactivation of essential oil ingredients, increase bioavailability and thus efficiency (significant for use against the bacteria and endoparasites in the intestinal tract). The application of these techniques also enables the controlled release of active substances, which can also be important for some applications such as antiectoparasitic. Finally, encapsulation increases the ease of application and also reduces unpleasant smells and tastes, which is very important for the use of essential oils in animal feed. From all the above, it can be concluded that encapsulation techniques have multiple implications for the application of essential oils in veterinary practice with enabling simpler, more practical, efficient, and thus wider application of these natural products.

Previous experimental models on cows have examined the difference in the metabolic adaptation in cows after niacin administration, without identifying the most important mediators between niacin administration and its biological effects, namely active forms of niacin. All tissues in the body convert absorbed niacin into its main metabolically active form, the coenzyme nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). The aim of this study was to determine the influence of niacin administration in periparturient period on NAD, NADP and the NAD:NADP ratio and to determine relationship between these indicators of an active form of niacin with metabolic parameters in cow blood. The study included 90 healthy cows: 45 cows receiving niacin and 45 cows were negative control. The niacin group was treated with nicotinic acid for two weeks before, as well as two weeks after parturition. Nicotinic acid was applied per os with feed. In cows receiving niacin, there was a significantly higher concentration of NAD and NADP, but the NAD:NADP ratio did not differ compared with control. All three indicators were able to separate cows who received and who did not receive additional niacin. NAD and NADP are good indicators of the availability of niacin from additional sources. The NAD:NADP ratio is a good indicator of the biological effect of applied niacin on metabolites in cows due to its correlation with a number of metabolites: positive correlation with glucose, insulin, glucose to insulin ratio and the revised quantitative insulin sensitivity check index (RQUICKIBHB) of insulin resistance, triglycerides and cholesterol, and a negative correlation with nonesterified fatty acid (NEFA), beta hydroxybutyrate (BHB), gamma-glutamyltranspherase (GGT) and urea in cows receiving niacin. The same amount of added niacin in feed can produce different concentrations of NAD, NADP and NAD:NADP in the blood, and this was not related to their concentra

The development of anthelmintic resistance in sheep gastrointestinal nematodes (GINs) requires novel strategies for the sustainable control of these parasites. This study aimed to evaluate the anthelmintic efficacy of the Origanum vulgare (L.) essential oil (EO) against sheep GINs and to evaluate the possibility of its use in control practice. The in vitro egg hatch test was conducted at eight different concentrations (50, 12.5, 3.125, 0.781, 0.195, 0.049, 0.025, and 0.0125 mg/mL) of the tested EO. For the in vivo fecal egg count reduction test, the EO of O. vulgare was administrated orally at a mean single dose of 150 mg/kg to sheep from two farms in Southern Italy, whereby potential toxic effects to the hosts were also evaluated. In the egg hatch test, the inhibition of egg hatchability varied from 71.3% to 93.7%, depending on the concentration used. The high anthelmintic potential was confirmed in the fecal egg count reduction test with an average reduction of nematode eggs in feces of 43.2% and 60.1% on days 7 and 14 after treatment, respectively. In addition, no toxic effects were noticed during the clinical examination of sheep or by observing blood count and liver or kidney function test results. The obtained results suggest the strong activity of the O. vulgare EO against sheep GINs, probably due to a high percentage of carvacrol (76.21%), whereby it can be considered safe for sheep at the dose tested in vivo. Therefore, it is suitable for use in veterinary practice as a part of an integrated strategy for the control of sheep GINs.

Sepsis can be defined as a multisystem response of the organism on bacterial infection agents. The aim of this study is to provides an extensive analysis of associations between numerous routine biochemical and hematological markers in function of type of sepsis caused by experimental Gram-positive (G+, Staphylococcus aureus), Gram-negative (G-, Escherichia coli) and mixed (MIX) microorganism in laboratory rats model. In G- and G+ sepsis higher values of erythrocytes, total protein, albumin, creatinine, sodium and plasma osmolarity were noted and lower triglycerides values compared to MIX sepsis. Existence of statistically significant interaction between time and type of sepsis was showed that values of erythrocytes, neutrophiles, LUC, glucose, total protein, urea, Na, Cl, osmolarity and LDH were changed during time in function of sepsis type. Distinguish of animals with G+, G- or MIX sepsis is not possible because principal component analysis (PCA) demonstrated similar expression of blood hematological and metabolic parameters in animals regardless type of experimental sepsis (G+, G- or MIX), with minimal deviation of animal with MIX sepsis from animals with sepsis caused by pure culture (G+ or G-). Correlation coefficient analysis showed 507 significant correlations between routine blood parameters (207 in G-, 186 in G+ and 114 in MIX) and some of them are in function of type of sepsis. Distinguish of type of sepsis in function of blood parameters is not possible. After extraction of two components they load by blood parameters was similar in all type of sepsis (positive load with different type of white blood cells, PLT, glucose, amylase, Cl, urea and osmolarity, and negative load with albumin, total protein, cholesterol, creatinine and ALT). Although our results demonstrated difference in values and correlation coefficients for routine blood biochemistry and hematology parameters, multiparametric statistic showed they not be a useful tool for distinguishing type, Sepsa se može definisati kao multisistemski odgovor organizma na uzročnike bakterijske infekcije. Cilj ove studije je da pruži opsežnu analizu povezanosti brojnih rutinskih biohemijskih i hematoloških markera u funkciji tipa sepse izazvane eksperimentalnim Gram-pozitivnim (G+, Staphylococcus aureus), Gramnegativnim (G-, Escherichia coli) i mešani (MIX) mikroorganizam u modelu laboratorijskih pacova. U G- i G+ sepsi su zabeležene više vrednosti eritrocita, ukupnog proteina, albumina, kreatinina, natrijuma i osmolarnosti plazme i niže vrednosti triglicerida u odnosu na MIX sepsu. Utvrđeno je postojanje statistički značajne interakcije između vremena i tipa sepse da su se vrednosti eritrocita, neutrofila, LUC, glukoze, ukupnog proteina, uree, Na, Cl, osmolarnosti i LDH menjale tokom vremena u funkciji tipa sepse. Razlikovanje životinja sa G+, G- ili MIX sepsom nije moguće jer je analiza glavnih komponenti (PCA) pokazala sličnu ekspresiju hematoloških i metaboličkih parametara krvi kod životinja bez obzira na tip eksperimentalne sepse (G+, G- ili MIX), uz minimalno odstupanje od životinja sa MIX sepsom od životinja sa sepsom izazvanom čistom kulturom (G+ ili G-). Analiza koeficijenta korelacije pokazala je 507 značajnih korelacija između rutinskih parametara krvi (207 kod EC, 186 kod SA i 114 kod MIX sepse) i neke od njih su u funkciji tipa sepse. Nije moguće razlikovati vrstu sepse u funkciji parametara krvi. Nakon ekstrakcije dve komponente opterećenje po parametrima krvi bilo je slično kod svih vrsta sepse (pozitivno opterećenje različitim vrstama belih krvnih zrnaca, PLT, glukozom, amilazom, Cl, ureom i osmolarnošću, a negativno albuminom, ukupnim proteinom, holesterolom , kreatinin i ALT). Iako su naši rezultati pokazali razliku u vrednostima i koeficijentima korelacije za rutinske biohemijske i hematološke parametre krvi, multiparametarska statistika je pokazala da oni nisu korisno sredstvo za razlikovanje tipa sepse prema bakterijskom uzročniku.

Kontrola zdravlja vimena krava je bitan element u procesu proizvodnje zdravstveno bezbednog mleka, te se na farmama visokomlečnih krava, kroz program kontrole mastitisa, redovno sprovode mere otkrivanja i prevencije bolesti vimena. Klinički pregled vimena predstavlja osnovni metod koji pruţa korisne informacije o zdravstvenom statusu vimena krava, ali nailazi na poteškoće u otkrivanju patoloških promena unutar parenhima i papile vimena. U cilju otkrivanja promena u parenhimu vimena moţe se primeniti ultrazvučni pregled koji omogućava vizualizaciju strukturnih promena vimena nastalih kao posledica upalnih procesa i tako olakšava dijagnostiku oboljenja. Tokom poslednjih godina, javio se problem povećanja rezistencije bakterija na antimikrobne lekove, što oteţava lečenje bolesti, ali i ugroţava zdravlje ţivotinja i ljudi. Najčešći uzroci toga su nepravilna upotreba i eventualna zloupotreba antimikrobnih lekova. Mnoga istraţivanja vršena su u in vitro i in vivo uslovima na primeni laktoferina samog ili u kombinaciji sa antibioticima u terapiji i prevenciji mastitisa krava. Laktoferin, gvoţĎe vezujući antimikrobni glikoprotein koji se nalazi u mleku i drugim sekretima, predstavlja bitan deo sistema odbrane mlečne ţlezde. Cilj istraţivanja u okviru ove disertacije je procena dijagnostičke mogućnosti ultrazvučnog pregleda u detekciji subkliničkog mastitisa i poremećene sekrecije vimena, kao i razmatranje opravdanosti primene laktoferina u prevenciji i lečenju mastitisa. Kliničkim pregledom izvršena je procena opšteg zdravstvenog stanja krava, kao i ispitivanje mlečne ţlezde adspekcijom i palpacijom. Za otkrivanje poremećene sekrecije vimena i subkliničkih mastitisa korišćeni su brzi testovi, Kalifornija mastitis test i Draminski test, kao i ultrazvučni pregled mlečne ţlezde krava. OdreĎivanje broja somatskih ćelija u uzorcima mleka uraĎeno je metodom protočne citometrije. Za identifikaciju uzročnika mastitisa korišćene su klasične mikrobiološke metode. Krave sa pozitivnim, Control of udder health is an essential element in the process of safe milk production, thus, through the mastitis control program, dairy farms regularly conduct measures of detection and prevention of udder diseases. Clinical examination of the udder is a basic method that provides useful information about the health status of cow udders, but this method is limited in its ability to detect pathological changes in the udder parenchyma and teat. In order to detect changes in the parenchyma of the udder, an ultrasound can be applied which allows visualization of udder structural changes incurred as a result of inflammatory processes, thus facilitating diagnosis of diseases. Over the last few years, the problem of increasing resistance to antimicrobial drugs has appeared, making it difficult to treat disease and also threaten the health of animals and humans. The incorrect and widespread use of antimicrobial drugs are the most common cause of this. Many studies were conducted in vitro and in vivo conditions on the use of lactoferrin alone or in combination with antibiotics in the treatment and prevention of mastitis. Lactoferrin, an iron-binding antimicrobial glycoprotein which is found in milk and other secretions, represents an important part of the mammary gland defense system. The aim of the research within this thesis was to evaluate the diagnostic possibilities of udder ultrasonography in the detection of subclinical mastitis and udder secretion disorders, as well as considering the feasibility of lactoferrin application in the prevention and treatment of mastitis. The general condition of the animals was evaluated by clinical examination, as well as udder examination by adspection and palpation. The California mastitis test, Draminski test and ultrasound examination of the cow's mammary glands were used for detection of udder secretion disorders and subclinical mastitis. Somatic cell count in milk samples was determined by flow cytometry method. Classical microb

Kompjuterizovana tomografija (CT) je jedan od najznačajnijh dijagnostičkih modaliteta, čija upotreba raste iz decenije u deceniju. U ukupnom broju radioloških pregleda CT je zastupljena sa 5-10%, ali je njen doprinos ukupnoj dozi za populaciju veći od 50%. Osnovni pokazatelji kvaliteta slike i doza, kao i prateći radijacioni rizik zavise od primenjene radiografske tehnike odnosno CT pregleda. U smislu dobre radiološke prakse i u skladu sa osnovnim principima zaštite od zračenja, poželjna je primena najniže moguće doze za pacijenta uz održavanje kvaliteta slike i dijagnostičke informacije. Cilj istraživanja jeste definisanje optimalnog protokola pregleda višeslojnom CT za dijagnozu pojedinih regija tela, kao i da se utvrde doze i radijacioni rizik za pacijente pre i nakon optimizacije protokola. Analizom je obuhvaćeno ukupno 437 pacijenata, koji su podeljeni u grupe prema regijama tela koje su snimane: I–nekontrastni CT glave, II-CT glave sa i.v. kontrastom, III-CT grudnog koša, IV-CT abdomena i karlice i V-CT angio (CT angiografija aortoilijačnog segmenta i donjih ekstremiteta). Studija je izvedena u 2 faze: u I fazi je korišćen standardni protokol za regiju tela koja se snimala, a u II fazi CT pregledi su izvedeni po modifikovanom protokolu (promenom parametra vrednosti mAs), uz minimalne zahteve u pogledu kvaliteta slike.Na osnovu dozimetrijskih pokazatelja procenjena je efektivna doza i radijacioni rizik za pacijente u obe faze. U studiji su korišćene smernice iz Vodiča EUR 16262 EN, u kojima su definisani parametri za procenu kvaliteta slike da bi se analizirali različiti anatomski preseci određenih regija tela koji su se snimali. Kvalitet slike za svakog pacijenta je ocenjen pomoću trostepene skale vizualizacije za svaki parametar anatomske regije: 0-detalji su vidljivi, 1-detalji se prikazuju, 2-detalji se jasno prikazuju. Korišćena je subjektivna metoda gde su dva iskusna radiologa vršili interpretaciju slike. Konačna ocena kvaliteta slike svakog pregleda, Computed tomography (CT) is one of the most significant diagnostic methods whose application has been increasing from decade to decade. Among the total number of radiological examinations CT accounts for 5-10%, however, its contribution in the whole dosage for the population is greater than 50%. Main indicator of the quality of images and dosages as well as the accompanying irradiation risk depend on applied radiographic technique that is CT examination. In the sense of good radiological practice and in accordance with basic principles of protection from irradiation, the application of the lowest possible dosage for a patient together with preserving the quality of image and diagnostic information are mostly welcomed. The goal of the research is to define the optimum examination protocol by multislice CT in diagnostics of certain body regions as well as to determine dosages and irradiation risk for patients both before and after protocol optimization. The analysis has included 437 patients divided into groups according to body regions which have been scanned: I-unenhanced head CT, II contrast enhanced head CT, III–chest CT, IV–abdomen and pelvis CT and V–angio CT (CT angiography of aortoiliac segment and lower extremities). The study has been conducted in 2 phases: in the first phase standard protocol for the scanned body region has been applied, and in the second phase CT examinations have been carried out according to the modified protocol (by change of parameters of values mAs) with minimum requirements regarding the image quality. On the basis of dosimetric indicators the efficient dosage and irradiation risk for the patients in both phases have been assessed. In the study the guidelines form the Guide EUR 16262 EN have been observed where parameters for the assessment of image quality have been defined in order to analyze different anatomic cross sections of certain body regions. Image quality for each patient

Uvod: Termin - temporomandibularne disfunkcije (TMD) obuhvata veći broj oboljenja TMZ, mastikatorne muskulature i okolnih struktura. Epidemiološke studije pokazuju da 50-75% osoba u toku života ima neki znak poremećaja funkcije mastikatornog sistema. TMD se najčešće javljaju između 20-40 godine života. Najznačajniji znaci i simptomi TMD su bol u predelu maseteričnog mišića, TMZ, regiona temporalnog mišića, ograničeno otvaranje usta i zvučne pojave (kliktaji i krepitacije). Bol u predelu TMZ je najčešći razlog javljanja pacijenta lekaru. Cilj Utvrđivanje validnosti kliničkog nalaza TMD dobijenog korišćenjem RDC/TMD (engl. Research Diagnostic Criteria/ Temporomandibular Disorders) i nalaza na MR pregledu radi utvrđivanja prisustva disfunkcije u cilju blagovremenog i adekvatnog kliničkog zbrinjavanja. Istraživanje je sprovedeno kao prospektivna studija u Centru za Imidžing dijagnostiku, Institutu za Onkologiju Vojvodine u Sremskoj Kamenici, u periodu od januara 2011. do maja 2013. godine. Istraživanjem je obuhvaćeno 200 ispitanica (400TMZ) koje su došle na zakazani MR pregled endokranijuma nevezano za eventualnu patologiju TMZ tj. zbog neurološke simptomatologije. Ispitanicama je prvo snimljen MR endokranijuma zbog osnovnog oboljenja a zatim je pregled nastavljen snimanjem oba TMZ. Snimanje je izvedeno na aparatu Siemens (Erlangen, SR Nemačka) jačine magnetnog polja 3Tesla – Siemens AVANTO 3T, istog dana, nakon obavljenog kliničkog pregleda. Svakoj ispitanici urađen je parasagitalni (Slika 8) i koronalni presek TMZ kroz oba kondila sa sledećim parametrima snimanja: proton density sekvenca, vreme repeticije (TR) 1850 ms, vreme ehoa (TE) 15 ms, vidno polje (FOV) 13 cm, kao i matrica 128 x 256. Debljina preseka prilikom snimanja MR bila je manja od 2 mm. Prilikom snimanja svakoj ispitanici je bio stavljen osmokanalni zapreminski kalem (engl. head matrix coil) da bi signal u antero-posteriornom pravcu na dobijenim snimcima bio ujednačen. Ukupno vreme snimanja oba TMZ iznos, Introduction The term temporomandibular disorders (TMD) encompasses a large number of diseases of TMJ, masticatory musculature and surrounding structures. Epidemiological studies show that 50-75% of people have some type of impaired function of the masticatory system in the course of their lives. TMJ most commonly occurs between the ages of 20 to 40. The most important signs and symptoms of TMD are the pains in the area of masseter muscle; TMJ; temporal muscle; with limited mouth opening and sound phenomena (clicking and crepitus). Pain in the TMJ is the most common reason for a patient’s visit to a doctor. The aim To determine the validity of the clinical findings of TMD obtained by using RDC / TMD (Research Diagnostic Criteria / Temporomandibular Disorders) and MRI examination findings which could determine the presence of a disorder and therefore provide prompt and adequate clinical care. Materials and Methods The research was conducted as a prospective study at the Diagnostic Imaging Center, Oncology Institute of Vojvodina in Sremska Kamenica in the period from January 2011 to May 2013. The study included 200 subjects (400 TMJs) who came for a scheduled MRI of endocranium not related to potential TMJ pathology i.e. having neurological symptoms. Firstly, the subjects underwent the MRI of the endocranium due to their underlying diseases and then the examination continued with MRI of both TMJs. The imaging was performed using Siemens device (Erlangen, Germany) with the magnetic field strength 3Tesla - Siemens Avanto 3T the same day after their clinical examination. Each subject underwent a parasagital and coronal cross section of TMJ through both condyles with the following imaging parameters: proton density sequence, repetition time (TR) 1850 ms, echo time (TE) 15 ms, field of view (FOV) 13 cm and a matrix of 128 x 256. The section thickness during MRI was less than 2 mm. During imaging, 8-channel head matrix coil was placed on each subject so that the signa

Uvod: Hronični subduralni hematom (HSDH) je učestala i nezanemarljiva traumatska/netraumatska intrakranijalna lezija, naročito kod pacijenata starije životne dobi. Simptomi pacijenata sa HSDH su raznovrsni i često pogrešno protumačeni i lečeni. Zbog navedenih činjenica, HSDH predstavlja veliki izazov u dijagnostici i terapiji. Različiti autori ističu značaj radioloških parametara tokom dijagnostike ovog oboljenja i povezanost sa kliničkom slikom I neurološkim statusom pacijenta, pa je ovo istraživanje bilo usmereno u preciznoj evaluaciji pomenutih parametara, njihovoj prediktivnoj vrednosti i uticaju na prognozu ishoda lečenja. Cilj: Generalni cilj istraživanja je bio da se ispita učestalost pacijenata sa hroničnim subduralnim hematomom na teritoriji Vojvodine u periodu od tri godine; da se analizira starosna dob pacijenata, polna distribucija oboljenja, uticaj komorbiditeta ili faktora rizika na nastanak HSDH; prisustvo ili odsustvo traume koja je doprinela nastanku HSDH, vremenski interval od traume do pojave simpotoma ili znakova bolesti i da se omogući praćenje efekta terapije pacijenata sa ovim oboljenjem. Specifični ciljevi su obuhvatili: 1. Da se utvrde parametri kompjuterizovane tomografije koji imaju prediktivni značaj u pozitivnom ishodu lečenja pacijenata sa hroničnim subduralnim hematomom. 2. Da se utvrde klinički parametri koji imaju prediktivni značaj u pozitivnom ishodu lečenja pacijenata sa hroničnim subduralnim hematomom. 3. Da se dobije model sa najvećom specifičnošću i senzitivnošću za predikciju ishoda lečenja, kombinacijom kliničkih i parametrara kompjuterizovane tomografije kod pacijenata sa hroničnim subduralnim hematomom. Materijal i metode: Istraživanje je obavljeno kao prospektivna trogodišnja studija u periodu od aprila 2010. do aprila 2013. godine u Kliničkom Centru Vojvodine- Centru za radiologiju i Klinici za neurohirurgiju i obuvatila je 83 pacijenata sa dijagnozom hroničnog subduralnog hematoma. Svi ispitanici su dijagnostikovani upot, Introduction: Chronic subdural hematoma (CSDH) is common traumatic/no traumatic intracranial lesion, especially in older patients. Symptomatology of this disease is variable and often is misdiagnosed and treated with specially challenges in diagnostic and therapy. Different authors pointed on importance of radiological parameters during diagnostic of this disease and connections with clinic and neurological status in patients with chronic subdural hematoma (CSDH), so this thesis was directed to evaluate radiological and clinical parameters of CSDHs and to show their predictive values and their significance on patient’s outcome. Aim: General aim of this thesis was to examine frequency of patients with chronic subdural hematoma in Vojvodina, during the period of three years, to analyze the age of population with CSDHs, the gender distribution, an impact of comorbidity or risk factors for patients with CSDHs, the presence or absence of trauma which has contributed to CSDH, to determine time interval from trauma to appearance of symptoms and signs of disease, monitoring the effect of therapy. Specific aims were: 1. To determine clinical parameters with a positive predictive significance on patients outcome 2. To determine radiological parameters with a positive predictive significance on patients outcome 3. To determine optimal prognostic model with high specificity and sensitivity, using combination of radiological and clinical parameters for positive prediction outcome. Material and methods: The study was performed as three-year prospective study from April 2010 to April 2013 in Clinical Centre of Vojvodina, Centre for Radiology and Clinic of Neurosurgery and includes 83 patients with chronic subdural hematoma. All patients were diagnosed using computed tomography of the brain (CT scan) and all were treated in Clinic of Neurosurgery (KCV). Data sources included the medical records of each patient from the time of first hospitalization to period of their discharge and