19 results on '"Philipp, Rebecca"'
Search Results
2. Existential distress among family caregivers of patients with advanced cancer: A systematic review and meta‐analysis.
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Walbaum, Charlotte, Philipp, Rebecca, Oechsle, Karin, Ullrich, Anneke, and Vehling, Sigrun
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PSYCHOLOGICAL distress , *CANCER patients , *CAREGIVERS , *PATIENT-family relations , *PATIENTS' families , *LONELINESS , *QUALITY of life - Abstract
Objective: Caregiving for a loved one is challenging and requires significant resources. Existential distress in family caregivers may include hopelessness, demoralization, fear of death, pre‐loss grief, or a sense of not being emotionally prepared. The aim of this systematic review is to synthesize the quantitative literature on existential distress among family caregivers of patients with advanced cancer, focusing on its prevalence, association with mental disorders, as well as with sociodemographic, disease, and treatment‐related factors. Methods: We systematically searched electronic databases for quantitative studies of the above‐described existential distress concepts in family caregivers of patients with advanced cancer. Two independent reviewers extracted data and evaluated study quality. Data were analyzed using random‐effects meta‐analysis. Results: We retrieved 17.587 records, of which 31 studies fulfilled inclusion criteria. 63% of the studies (n = 20) provided sufficient data for meta‐analysis for 5558 patients. We found an overall pooled prevalence of 30.6% for existential distress, 95% CI [24.2–37.0]. For existential distress subconcepts, prevalence rates were 57.0%, 95% CI [37.8–76.2], for death anxiety, 13.9%, 95% CI [10.8–17.0], for demoralization, 24.0%, 95% CI [18.0–30.0], for pre‐loss grief, 18.4%, 95% CI [4.0–32.7], for hopelessness, 35.2%, 95% CI [28.2–42.2], for loneliness, and 35.6%, 95% CI [13.0–58.3], for emotional unpreparedness. Conclusions: Approximately one third of the respondents were affected by high levels of existential distress. The review provides evidence for further development of support services that can reduce existential distress, focused on death anxiety, and improve the quality of life for family caregivers of patients with advanced cancer. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Understanding avoidant attachment in a patient with terminal cancer: a psychoanalytic perspective.
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Philipp, Rebecca, Krüger, Alexander, Lindner, Reinhard, Mehnert-Theuerkauf, Anja, and Vehling, Sigrun
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CANCER patient psychology , *BRIEF psychotherapy , *AFFECT (Psychology) , *REPRESSION (Psychology) , *TERMINALLY ill , *DENIAL (Psychology) , *GUILT (Psychology) , *FEAR , *ATTACHMENT behavior , *RANDOMIZED controlled trials , *QUALITATIVE research , *PATIENTS' attitudes , *ATTITUDES toward illness , *SOCIAL isolation , *TREATMENT effectiveness , *CONTENT analysis , *SHAME , *AVOIDANT personality disorder , *DEPENDENCY (Psychology) , *PSYCHOLOGICAL distress , *ATTITUDES toward death - Abstract
Describing the course of a short-term supportive-expressive psychotherapy of a male patient with terminal cancer, this study aimed to illustrate the clinical presentation of avoidant attachment behavior and to identify potential challenges in treating these patients from a psychoanalytic perspective. We analyzed eight therapy sessions, recorded and transcribed as part of a randomized controlled trial, following the explication technique of qualitative content analysis. We analyzed a patient with high attachment avoidance as assessed by the Experiences in Close Relationships Scale measuring adult attachment. We found that 'attachment avoidance' subsumed different defense mechanisms, which helped the patient to reduce his fear associated with (1) feelings of dependency: denial, (2) overwhelming distress: isolation of affect, displacement, (3) feelings of guilt and shame: repression, (4) regulating his interpersonal relationships: projective identification. Adding psychoanalytic interpretations to the existing material helped to identify rigid defense mechanisms interfering with sharing his fears about death and dying. Still, the low intensity setting offered him a reliable and tolerable therapeutic relationship. Contributing to the understanding of the specific challenges in treating avoidant patients, our findings underline the importance and feasibility of establishing a holding environment and fostering a positive transference relationship to engage in a joint mourning process. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Psychometric properties of a patient‐reported outcome set in acute stroke patients.
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Philipp, Rebecca, Lebherz, Lisa, Thomalla, Götz, Härter, Martin, Appelbohm, Hannes, Frese, Marc, and Kriston, Levente
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PSYCHOMETRICS , *HEALTH outcome assessment , *PATIENT reported outcome measures , *STROKE patients , *SYMPTOMS - Abstract
Objectives: Impairments after stroke may affect multiple domains of health‐related quality of life (HRQoL). Patient‐reported outcome measures (PROMs) have proven valuable in measuring patients' well‐being. We examine the psychometric properties of a standard set of PROMs assessing global health, anxiety, and depression, and functioning in a German health care setting. Method: We included inpatients at the Department of Neurology at the University Medical Center Hamburg‐Eppendorf, diagnosed with stroke. Following the stroke‐specific standard set of the International Consortium for Health Outcome Measurement, we collected demographic and clinical information at baseline, and PROMs for global health (PROMIS‐10), three items for self‐reported functioning, anxiety, and depression (PHQ‐4) at 90 days follow‐up. We calculated confirmatory factor analyses to test factorial validity and correlation analyses to test construct validity. We further conducted item and reliability analyses. Results: In a sample of 487 patients (mean age, SD: 71.1, 12.6; 47% female) with mild and moderate symptoms, model fit for the PROMIS‐10 was acceptable for the two‐factor and single‐factor models. Factor loadings ranged from 0.52 to 0.94. The postulated single‐factor model for functioning was saturated with zero degrees of freedom. Factor loadings ranged from 0.90 to 0.96. For the PHQ‐4, the two‐factor model showed excellent model fit. Factor loadings ranged from 0.78 to 0.87. Internal consistency was acceptable to good. Construct validity was generally confirmed. Conclusions: The PROMIS‐10 is a valid and reliable instrument to measure HRQoL among German stroke patients. While the PHQ‐4 was confirmed as a screening measure for mental disorders, further research is needed on items assessing self‐reported functioning. Results are limited to patients showing minimal functional deficits. [ABSTRACT FROM AUTHOR]
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- 2021
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5. The role of attachment avoidance: A longitudinal mediation model predicting existential distress in patients with advanced cancer.
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Philipp, Rebecca, Mehnert‐Theuerkauf, Anja, Koranyi, Susan, Härter, Martin, and Vehling, Sigrun
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PSYCHOLOGICAL distress , *INTERPERSONAL relations , *AVOIDANCE (Psychology) , *PSYCHOLOGICAL factors , *CANCER patients - Abstract
Objective: Although a protective effect of reliable interpersonal relationships on existential distress has been established, evidence remains inconclusive for attachment insecurity as an underlying factor of persistent psychological distress. We tested a longitudinal model hypothesizing attachment avoidance as a mediator of high demoralization and anxiety over time. Methods: We studied 206 patients with advanced cancer (mean age = 59.6, 61% female) participating in an intervention trial. Patients completed self‐report measures for demoralization, anxiety, perceived relatedness, attachment insecurity, and death anxiety. Our mediated path model included perceived relatedness and death anxiety at baseline as predictors, attachment avoidance at baseline as mediator, and demoralization and anxiety at 6‐month follow‐up (N = 125) as outcomes. Results: Attachment avoidance partially mediated the relationship between death anxiety and demoralization (β = 0.07, 95% CI 0.02–0.12) and anxiety (β = 0.05, 95% CI 0.001–0.10). Findings for perceived relatedness were less conclusive. Its indirect effects through attachment avoidance were significant for both outcomes (demoralization: β = −0.07, 95% CI −0.13 to −0.02, anxiety: β = −0.05, 95% CI −0.11 to −0.003). Conclusions: Due to its trait‐like quality, attachment avoidance may play a less central role in explaining the course of existential distress over time than previous research indicated. Addressing change‐sensitive relational concerns in psychosocial interventions may be more effective to alleviate existential distress. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Perceived relatedness, death acceptance, and demoralization in patients with cancer.
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Philipp, Rebecca, Mehnert, Anja, Müller, Volkmar, Reck, Martin, and Vehling, Sigrun
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TUMOR classification , *CANCER patients , *MULTIPLE regression analysis , *POSTTRAUMATIC growth , *RELATIONSHIP quality , *PATIENT acceptance of health care , *PSYCHO-oncology , *MENTAL depression , *ADAPTABILITY (Personality) , *REGRESSION analysis , *PSYCHOMETRICS , *ATTITUDES toward death , *PSYCHOLOGICAL stress , *PSYCHOLOGICAL factors ,TUMORS & psychology - Abstract
Purpose: Close relationships can be strained by losses related to independence, autonomy, and separation after diagnosis of severe illness. The perceived quality of their close relationships affects individuals' psychological adaptation in this context. We explored the level of perceived relatedness and its impact on demoralization and death acceptance. We further examined a possible protective effect of perceived relatedness on the association between tumor stage and death acceptance.Methods: For this observational study, we consecutively recruited gynecology outpatients and general surgery inpatients at the University Cancer Center Hamburg-Eppendorf and oncological inpatients at the LungenClinic Grosshansdorf, Germany. At baseline, 307 patients (age M = 59.6, 69% female, 69% advanced cancer) participated. At 6- and 12-month (T3) follow-up, 213 and 153 patients responded, respectively. Patients completed self-report questionnaires including a modified version of the Posttraumatic Growth Inventory assessing perceived relatedness, the Life Attitude Profile-Revised assessing death acceptance, the Demoralization Scale, and the Memorial Symptom Assessment Scale assessing symptom burden. We calculated multiple linear regression analyses controlling for demographic and disease-related factors.Results: Participants reported a stronger perceived relatedness at baseline (M = 3.04, SE = 0.03, possible range 0-4) than at T3 (M = 2.93, SE = 0.04; p = 0.02). Perceived relatedness significantly predicted lower demoralization at T3 but did not moderate the relationship between tumor stage and demoralization. Apart from male gender, none of the predictor or moderator variables had a significant impact on death acceptance at T3.Conclusions: The strong impact of perceived relatedness on existential distress emphasizes the importance of strengthening interpersonal relationships within psychosocial interventions. [ABSTRACT FROM AUTHOR]- Published
- 2020
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7. Inter-professional teamwork and its association with patient safety in German hospitals—A cross sectional study.
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Dinius, Julia, Philipp, Rebecca, Ernstmann, Nicole, Heier, Lina, Göritz, Anja S., Pfisterer-Heise, Stefanie, Hammerschmidt, Judith, Bergelt, Corinna, Hammer, Antje, and Körner, Mirjam
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PATIENT safety , *HEALTH care teams , *STATISTICAL sampling , *INPATIENT care , *HOSPITALS , *FAILURE mode & effects analysis , *CAREGIVERS , *EMPLOYMENT forecasting - Abstract
Background: Inter-professional teamwork is a prominent factor in quality of care and may lead to improved patient safety. Although team members' points of view are highly relevant when trying to improve inpatient procedures, there is a lack of systematic assessment of their perceptions. Therefore, study aims were to explore inter-professional teamwork, safety-related behavior, and patient safety in German hospitals from team members' point of view. Furthermore, we wanted to examine the association between inter-professional teamwork and safety-related behavior as well as the association between inter-professional teamwork and patient safety. Methods: We used cross-sectional pre-intervention data of a multicenter longitudinal study (German KOMPAS project). We gathered descriptive statistics for sample characteristics and to describe the current state of inter-professional teamwork, safety-related behavior, and patient safety. We used one-way variance analyses to assess differences between groups, and linear regression analyses to examine the association between inter-professional teamwork and the outcomes safety-related behavior, and patient safety. Results: 326 inpatient care team members participated in the study. Participants perceived a moderate to high level of inter-professional teamwork, and a moderate level of patient safety. Moreover, they reached rather high values in safety-related behavior. Professional group, work experience, and period of employment had an impact on the perceptions of inter-professional teamwork, and patient safety. Higher inter-professional teamwork was associated with better patient safety. We did not find an association between inter-professional teamwork and safety-related behavior. Conclusions: Based on the association between inter-professional teamwork and patient safety, we recommend the implementation of team interventions. Because professional group, period of employment, and work experience had an impact on the perceptions of inter-professional teamwork and patient safety, we suggest future qualitative research to explore reasons for caregivers' critical evaluation. Moreover, we recommend longitudinal studies to reveal causal relationships, and subsequently to determine areas of improvement for a safer health care. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Spiritual well-being mediates the association between attachment insecurity and psychological distress in advanced cancer patients.
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Scheffold, Katharina, Philipp, Rebecca, Vehling, Sigrun, Koranyi, Susan, Engelmann, Dorit, Schulz-Kindermann, Frank, Härter, Martin, and Mehnert-Theuerkauf, Anja
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PSYCHOLOGICAL distress , *CANCER patients , *WELL-being , *ACADEMIC medical centers , *RANDOMIZED controlled trials - Abstract
Purpose: The diagnosis of a terminal disease bears existential challenges, which activate the attachment system. Attachment insecurity, as well as existential resources, such as spiritual well-being, influences patients' extent of psychological distress. Knowledge about the interrelation of these constructs is limited. Based on current research, we assume spiritual well-being to mediate the association of attachment insecurity and psychological distress.Methods: We obtained data from the baseline measurement of a randomized controlled trial in advanced cancer patients. Patients were sampled from the University Medical Centers of Hamburg and Leipzig, Germany. Main outcome measures included the Patient Health Questionnaire (PHQ-9), the Death and Dying Distress Scale (DADDS), the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp), and the Experience in Close Relationships Scale (ECR-M16) for assessing attachment insecurity. We tested the mediation hypothesis with two regression analyses using bootstrapping procedure.Results: A total of 190 patients were included. Spiritual well-being mediated the association of attachment insecurity and depression (R2 = 11%), as well as death anxiety (R2 = 15%), in fearful-avoidant attached patients. Neither dismissingly nor preoccupied attached patients differ in terms of spiritual well-being and psychological distress in comparison with secure attached patients.Conclusion: Spiritual well-being plays a relevant role in advanced cancer patient's mental health through mediating the association of attachment and psychological distress. Developing a better understanding of the interdependency of the constructs of spiritual well-being and attachment can help to develop individually tailored advanced cancer care programs and psychotherapeutic interventions.Trial Registration: NCT02051660. [ABSTRACT FROM AUTHOR]- Published
- 2019
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9. Characterizing death acceptance among patients with cancer.
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Philipp, Rebecca, Mehnert, Anja, Lo, Chris, Müller, Volkmar, Reck, Martin, and Vehling, Sigrun
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CANCER patients , *GENERAL Health Questionnaire , *GENERALIZED anxiety disorder , *PSYCHOLOGICAL distress , *ACCEPTANCE (Psychology) , *REGRESSION analysis - Abstract
Objective: Death acceptance may indicate positive adaptation in cancer patients. Little is known about what characterizes patients with different levels of death acceptance or its impact on psychological distress. We aimed to broaden the understanding of death acceptance by exploring associated demographic, medical, and psychological characteristics.Methods: At baseline, we studied 307 mixed cancer patients attending the University Cancer Center Hamburg and a specialized lung cancer center (age M = 59.6, 69% female, 69% advanced cancer). At 1-year follow-up, 153 patients participated. We assessed death acceptance using the validated Life Attitude Profile-Revised. Patients further completed the Memorial Symptom Assessment Scale, the Demoralization Scale, the Patient Health Questionnaire, and the Generalized Anxiety Disorder Questionnaire. Statistical analyses included multinomial and hierarchical regression analyses.Results: At baseline, mean death acceptance was 4.33 (standard deviation [SD] = 1.3, range 1-7). There was no change to follow-up (P = 0.26). When all variables were entered simultaneously, patients who experienced high death acceptance were more likely to be older (odds ratio [OR] = 1.04; 95% confidence interval [CI], 1.01-1.07), male (OR = 3.59; 95% CI, 1.35-9.56), widowed (OR = 3.24; 95% CI, 1.01-10.41), and diagnosed with stage IV (OR = 2.44; 95% CI, 1.27-4.71). They were less likely to be diagnosed with lung cancer (OR = 0.20; 95% CI, 0.07-0.58), and their death acceptance was lower with every month since diagnosis (OR = 0.99; 95% CI, 0.98-0.99). High death acceptance predicted lower demoralization and anxiety at follow-up but not depression.Conclusions: High death acceptance was adaptive. It predicted lower existential distress and anxiety after 1 year. Advanced cancer did not preclude death acceptance, supporting the exploration of death-related concerns in psychosocial interventions. [ABSTRACT FROM AUTHOR]- Published
- 2019
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10. Effectiveness of metacognitive interventions for mental disorders in adults—A systematic review and meta‐analysis (METACOG).
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Philipp, Rebecca, Kriston, Levente, Lanio, Jana, Kühne, Franziska, Härter, Martin, Moritz, Steffen, and Meister, Ramona
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MENTAL illness prevention , *MENTAL illness treatment , *BEHAVIOR therapy , *COGNITIVE therapy , *META-analysis , *PATIENT education , *PSYCHOTHERAPY , *PSYCHOTHERAPY patients , *SYSTEMATIC reviews , *PSYCHOSOCIAL factors , *SEVERITY of illness index , *PSYCHOEDUCATION , *ADULTS - Abstract
We evaluated the effectiveness and acceptability of metacognitive interventions for mental disorders. We searched electronic databases and included randomized and nonrandomized controlled trials comparing metacognitive interventions with other treatments in adults with mental disorders. Primary effectiveness and acceptability outcomes were symptom severity and dropout, respectively. We performed random‐effects meta‐analyses. We identified Metacognitive Training (MCTrain), Metacognitive Therapy (MCTherap), and Metacognition Reflection and Insight Therapy (MERIT). We included 49 trials with 2,609 patients. In patients with schizophrenia, MCTrain was more effective than a psychological treatment (cognitive remediation, SMD = −0.39). It bordered significance when compared with standard or other psychological treatments. In a post hoc analysis, across all studies, the pooled effect was significant (SMD = −0.31). MCTrain was more effective than standard treatment in patients with obsessive–compulsive disorder (SMD = −0.40). MCTherap was more effective than a waitlist in patients with depression (SMD = −2.80), posttraumatic stress disorder (SMD = −2.36), and psychological treatments (cognitive–behavioural) in patients with anxiety (SMD = −0.46). In patients with depression, MCTherap was not superior to psychological treatment (cognitive–behavioural). For MERIT, the database was too small to allow solid conclusions. Acceptability of metacognitive interventions among patients was high on average. Methodological quality was mostly unclear or moderate. Metacognitive interventions are likely to be effective in alleviating symptom severity in mental disorders. Although their add‐on value against existing psychological interventions awaits to be established, potential advantages are their low threshold and economy. [ABSTRACT FROM AUTHOR]
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- 2019
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11. Attachment Insecurity in Advanced Cancer Patients: Psychometric Properties of the German Version of the Brief Experiences in Close Relationships Scale (ECR-M16-G).
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Philipp, Rebecca, Vehling, Sigrun, Scheffold, Katharina, Grünke, Britta, Härter, Martin, Mehnert, Anja, Oechsle, Karin, Schulz-Kindermann, Frank, Lo, Christopher, Rebecca, Philipp, Sigrun, Vehling, Katharina, Scheffold, Britta, Grünke, Martin, Härter, Anja, Mehnert, Frank, Schulz-Kindermann, and Christopher, Lo
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MENTAL depression , *ONCOLOGY , *CANCER treatment , *CANCER patients , *INPATIENT care , *ANXIETY diagnosis , *DIAGNOSIS of mental depression , *TUMOR diagnosis , *ADAPTABILITY (Personality) , *COMPARATIVE studies , *FACTOR analysis , *INTERPERSONAL relations , *LEARNING , *NEUROPSYCHOLOGICAL tests , *RESEARCH methodology , *MEDICAL cooperation , *PSYCHOANALYTIC interpretation , *PSYCHOMETRICS , *RESEARCH , *SPIRITUALITY , *TRANSLATIONS , *TRUST , *EVALUATION research ,TUMORS & psychology - Abstract
Context: Attachment insecurity refers to difficulty in trusting and relying on others in times of need. Its underlying factors attachment anxiety and attachment avoidance have been empirically associated with impaired coping in advanced cancer and, therefore, should be considered in individually tailored medical and psychosocial treatment.Objectives: The objective of this study was to evaluate the psychometric properties of the German translation of the Brief Experiences in Close Relationships Scale (ECR-M16-G).Methods: We recruited 182 advanced cancer patients from outpatient psycho-oncology clinics of the University Medical Center Hamburg-Eppendorf and the University Medical Center Leipzig, local and external cancer care facilities. We performed confirmatory factor analysis to replicate the higher order factor structure reported in previous research. We conducted item and reliability analysis, also correlation analysis, to examine concurrent validity.Results: One hundred fifty-eight patients completed the ECR-M16-G (women 61%, mean age 57.9, SD = 11.1). We replicated the factor structure with the subscales Attachment Anxiety and Attachment Avoidance as second-order factors and Worrying about relationships, Frustration about unavailability, Discomfort with close others, and Turning away from others as first-order factors. An adjusted model that interchanged factor loadings of items 4 and 10 showed good fit (Comparative Fit Index = 0.94, Non-Normed Fit Index = 0.93, root mean square error of approximation = 0.05). Subscales showed acceptable to good internal consistency (anxiety α = .81 and avoidance α = .78). Attachment insecurity (mean = 3.1, SD = 1.0) was positively associated with depression, anxiety, demoralization (P < 0.001), and symptom burden (P = 0.02) and negatively associated with spiritual well-being (P < 0.001).Conclusion: The ECR-M16-G is a valid and reliable measure of attachment insecurity in patients with advanced cancer and can be recommended as a tool for clinical care and further research. [ABSTRACT FROM AUTHOR]- Published
- 2017
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12. Effectiveness of a training program for healthcare professionals on parental cancer: Results of a randomized controlled pilot‐study.
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Johannsen, Lene Marie, Frerichs, Wiebke, Philipp, Rebecca, Inhestern, Laura, and Bergelt, Corinna
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MEDICAL personnel , *COMMUNICATIVE competence , *CANCER patient care , *PSYCHOLOGISTS , *ONCOLOGY nursing - Abstract
Objective: Cancer patients parenting minor children face specific burden and supportive needs, which are often not adequately addressed by their healthcare professionals (HCPs), due to a lack of knowledge, self‐efficacy and competencies. Therefore, we developed a 3‐h intervention enhancing HCPs' competencies in caring for these patients. We pilot‐evaluated the intervention's feasibility and efficacy, assuming intervention group participants reveal higher improvements over time compared to non‐trained participants. Methods: We conducted a 3‐armed randomized controlled pilot‐trial (RCT), comparing face‐to‐face training (F2F), e‐Learning (EL), waitlist‐control group with three measurements (baseline, post‐training, 3‐month follow‐up). Primary outcome was the competency to approach child‐ and family‐related themes; secondary outcomes were knowledge, self‐efficacy in (specific) communication skills. Intervention effects were analyzed using linear mixed models. Results: Participants (n = 152) were mostly female (89%) and psychologists (38%; physicians 26%; nurses 18%). F2F and EL participants reported high training satisfaction. Analyses did not reveal any significant differences on the primary outcome between groups, but indicate positive intervention effects over time regarding secondary outcomes including knowledge and self‐efficacy in communication skills. Conclusions: This is the first pilot‐study evaluating a training for HCPs in oncology on parental cancer using a 3‐armed RCT. The 3‐h training program is a feasible approach and findings indicate to increase HCPs' knowledge and self‐efficacy in caring for cancer patients with minor children. Further research is needed to verify preliminary findings of this pilot study. The study was pre‐registered within the German Clinical Trial Register (DRKS‐00015794). [ABSTRACT FROM AUTHOR]
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- 2023
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13. Efficacy of a brief manualized intervention Managing Cancer and Living Meaningfully (CALM) adapted to German cancer care settings: study protocol for a randomized controlled trial.
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Scheffold, Katharina, Philipp, Rebecca, Engelmann, Dorit, Schulz-Kindermann, Frank, Rosenberger, Christina, Oechsle, Karin, Härter, Martin, Wegscheider, Karl, Lordick, Florian, Lo, Chris, Hales, Sarah, Rodin, Gary, and Mehnert, Anja
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CANCER patients , *GERMANS , *RANDOMIZED controlled trials , *RESEARCH protocols , *PSYCHO-oncology , *PSYCHOTHERAPY , *DISEASES - Abstract
Background: Although psycho-oncological interventions have been shown to significantly reduce symptoms of anxiety and depression and enhance quality of life, a substantial number of patients with advanced cancer do not receive psycho-oncological interventions tailored to their individual situation. Given the lack of reliable data on the efficacy of psycho-oncological interventions in palliative care settings, we aim to examine the efficacy of a brief, manualized individual psychotherapy for patients with advanced cancer: Managing Cancer and Living Meaningfully (CALM). CALM aims to reduce depression and death anxiety, to strengthen communication with health care providers, and to enhance hope and meaning in life. We adapted the intervention for German cancer care settings. Methods/Design: We use a single-blinded randomized-controlled trial design with two treatment conditions: intervention group (IG, CALM) and control group (CG). Patients in the CG receive a usual non-manualized supportive psycho-oncological intervention (SPI). Patients are randomized between the IG and CG and assessed at baseline (t0), after three (t1) and after 6 months (t2). We include patients with a malignant solid tumor who have tumor stages of III or IV (UICC classification). Patients who are included in the study are at least 18 years old, speak German fluently, score greater than or equal to nine on the PHQ-9 or/and greater than or equal to five on the Distress Thermometer. It is further necessary that there is no evidence of severe cognitive impairments. We measure depression, anxiety, distress, quality of life, demoralization, symptom distress, fatigue as well as spiritual well-being, posttraumatic growth and close relationship experiences using validated questionnaires. We hypothesize that patients in the IG will show a significantly lower level of depression 6 months after baseline compared to patients in the CG. We further hypothesize a significant reduction in anxiety and fatigue as well as significant improvements in psychological and spiritual well-being, meaning and post-traumatic growth in the IG compared to CG 6 months after baseline. Discussion: Our study will contribute important statistical evidence on whether CALM can reduce depression and existential distress in a German sample of advanced and highly distressed cancer patients. [ABSTRACT FROM AUTHOR]
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- 2015
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14. Efficacy of a brief manualized intervention Managing Cancer and Living Meaningfully (CALM) adapted to German cancer care settings: study protocol for a randomized controlled trial.
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Scheffold, Katharina, Philipp, Rebecca, Engelmann, Dorit, Schulz-Kindermann, Frank, Rosenberger, Christina, Oechsle, Karin, Härter, Martin, Wegscheider, Karl, Lordick, Florian, Lo, Chris, Hales, Sarah, Rodin, Gary, and Mehnert, Anja
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Background: Although psycho-oncological interventions have been shown to significantly reduce symptoms of anxiety and depression and enhance quality of life, a substantial number of patients with advanced cancer do not receive psycho-oncological interventions tailored to their individual situation. Given the lack of reliable data on the efficacy of psycho-oncological interventions in palliative care settings, we aim to examine the efficacy of a brief, manualized individual psychotherapy for patients with advanced cancer: Managing Cancer and Living Meaningfully (CALM). CALM aims to reduce depression and death anxiety, to strengthen communication with health care providers, and to enhance hope and meaning in life. We adapted the intervention for German cancer care settings. Methods/Design: We use a single-blinded randomized-controlled trial design with two treatment conditions: intervention group (IG, CALM) and control group (CG). Patients in the CG receive a usual non-manualized supportive psycho-oncological intervention (SPI). Patients are randomized between the IG and CG and assessed at baseline (t0), after three (t1) and after 6 months (t2). We include patients with a malignant solid tumor who have tumor stages of III or IV (UICC classification). Patients who are included in the study are at least 18 years old, speak German fluently, score greater than or equal to nine on the PHQ-9 or/and greater than or equal to five on the Distress Thermometer. It is further necessary that there is no evidence of severe cognitive impairments. We measure depression, anxiety, distress, quality of life, demoralization, symptom distress, fatigue as well as spiritual well-being, posttraumatic growth and close relationship experiences using validated questionnaires. We hypothesize that patients in the IG will show a significantly lower level of depression 6 months after baseline compared to patients in the CG. We further hypothesize a significant reduction in anxiety and fatigue as well as significant improvements in psychological and spiritual well-being, meaning and post-traumatic growth in the IG compared to CG 6 months after baseline. Discussion: Our study will contribute important statistical evidence on whether CALM can reduce depression and existential distress in a German sample of advanced and highly distressed cancer patients. [ABSTRACT FROM AUTHOR]
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- 2015
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15. Prevalence of mental disorders in patients with cancer compared to matched controls – secondary analysis of two nationally representative surveys.
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Vehling, Sigrun, Mehnert-Theuerkauf, Anja, Philipp, Rebecca, Härter, Martin, Kraywinkel, Klaus, Kuhnert, Ronny, and Koch, Uwe
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PSYCHIATRIC epidemiology , *CONFIDENCE intervals , *PHOBIAS , *POST-traumatic stress disorder , *CANCER patients , *COMPARATIVE studies , *DISEASE prevalence , *ODDS ratio , *SECONDARY analysis - Abstract
To compare prevalence rates of mental disorders in patients with cancer and general population controls. In two stratified nationally representative surveys, the 12-month prevalence of mental disorders was assessed in 2141 patients with cancer and 4883 general population controls by the standardized Composite International Diagnostic Interview (CIDI). We determined odds ratios (ORs) to compare the odds for mental disorders (combined and subtypes) in cancer patients with age- and gender-matched controls. The 12-month prevalences rate for any mental disorder was significantly higher in patients with cancer compared to controls (OR 1.28, 95% CI 1.14–1.45). Prevalence rates were at least two times higher for unipolar mood disorders (major depression: OR 2.07, 95% CI 1.71–2.51; dysthymia: OR 2.93, 95% CI 2.13–4.02) and mental disorders due to a general medical condition (OR 3.31, 95% CI 2.32–4.71). There was no significant elevation for anxiety disorders overall (OR 0.95, 95% CI 0.81–1.11). Mildly elevated prevalence rates emerged for post-traumatic stress disorder (OR 1.57, 95% CI 1.11–2.23) and social phobia (OR 1.57, 95% CI 1.07–2.31), while specific phobia (OR 0.82, 95% CI 0.67–1.00) and agoraphobia (OR 0.49, 95% CI 0.33–0.73) were significantly less frequent in cancer. While elevated depression rates reinforce the need for its systematic diagnosis and treatment, lower prevalences were unexpected given previous evidence. Whether realistic illness-related fears and worries contribute to lower occurrence of anxiety disorders with excessive fears in cancer may be of interest to future research. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Efficacy of the Managing Cancer and Living Meaningfully (CALM) individual psychotherapy for patients with advanced cancer: A single‐blind randomized controlled trial.
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Mehnert, Anja, Koranyi, Susan, Philipp, Rebecca, Scheffold, Katharina, Kriston, Levente, Lehmann‐Laue, Antje, Engelmann, Dorit, Vehling, Sigrun, Eisenecker, Christina, Oechsle, Karin, Schulz‐Kindermann, Frank, Rodin, Gary, and Härter, Martin
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PSYCHOTHERAPY patients , *RANDOMIZED controlled trials , *MENTAL depression , *PSYCHO-oncology , *GROUP psychotherapy , *CANCER patients , *BIBLIOTHERAPY - Abstract
Objective: We aimed to determine whether the Managing Cancer and Living Meaningfully (CALM) therapy is superior to a non‐manualized supportive psycho‐oncological counselling intervention (SPI). Methods: Adult patients with advanced cancer and ≥9 points on the PHQ‐9 and/or ≥5 points on the DT were randomized to CALM or SPI. We hypothesized that CALM patients would report significantly less depression (primary outcome) on the BDI‐II and the PHQ‐9 6 months after baseline compared to SPI patients. Results: From 329 eligible patients, 206 participated (61.2% female; age: M = 57.9 [SD = 11.7]; 84.5% UICC IV stage). Of them, 99 were assigned to CALM and 107 to SPI. Intention‐to‐treat analyses revealed significantly less depressive symptoms at 6 months than at baseline (P <.001 for BDI‐II and PHQ‐9), but participants in the CALM and SPI group did not differ in depression severity (BDI‐II: P =.62, PHQ‐9: P =.998). Group differences on secondary outcomes were statistically not significant either. Conclusions: CALM therapy was associated with reduction in depressive symptoms over time but this improvement was not statistically significant different than that obtained within SPI group. [ABSTRACT FROM AUTHOR]
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- 2020
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17. Measuring the Psychosocial Dimensions of Quality of Life in Patients With Advanced Cancer: Psychometrics of the German Quality of Life at the End of Life-Cancer-Psychosocial Questionnaire.
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Grünke, Britta, Philipp, Rebecca, Vehling, Sigrun, Scheffold, Katharina, Härter, Martin, Oechsle, Karin, Schulz-Kindermann, Frank, Mehnert, Anja, and Lo, Christopher
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CANCER invasiveness , *PSYCHOSOCIAL factors , *QUALITY of life , *TERMINAL care , *PSYCHOMETRICS , *PSYCHOLOGICAL well-being , *PSYCHOLOGY , *CANCER patient psychology , *FACTOR analysis , *QUESTIONNAIRES , *RESEARCH , *DESCRIPTIVE statistics ,RESEARCH evaluation - Abstract
Context: Quality of life (QoL) is a central focus of care in advanced cancer. Specialized instruments, such as the Quality of Life at the End of Life-Cancer (QUAL-EC), may be useful to assess psychosocial issues associated with QoL unique to this population.Objectives: To evaluate the measurement of the psychosocial dimensions of QoL using the German translation of the QUAL-EC-Psychosocial (QUAL-EC-P) questionnaire, including factor structure and psychometrics.Methods: About 183 patients with advanced cancer from the University Medical Center Hamburg-Eppendorf and University Medical Center Leipzig completed the QUAL-EC-P questionnaire. We conducted exploratory factor analysis as well as item and reliability analysis. We examined convergent validity with correlations between the scale and relevant psychological constructs.Results: The sample was 60% female with mean age of 57.7 (SD = 11.7). We extracted three factors accounting for 44% of the variance aligning with the structure of the instrument. The QUAL-EC-P questionnaire showed good to acceptable internal consistency for the QoL-psychosocial total score (α = 0.77), the Life completion subscale (α = 0.77), and the Relationship with health care provider subscale (α = 0.81). The Preparation for end of life subscale had adequate albeit low internal consistency (α = 0.64) because concerns about family were less associated with financial worry and fear of death than expected. The psychosocial dimensions of QoL correlated negatively with depression (r = -0.27, P ≤ 0.001), anxiety (r = -0.32, P ≤ 0.001), demoralization (r = -0.63, P ≤ 0.001), and attachment insecurity (r = -0.51, P ≤ 0.001) and positively with spiritual well-being (r = 0.63, P ≤ 0.001).Conclusion: The QUAL-EC-P questionnaire may be used to assess the psychosocial aspects of QoL and promote their clinical discussion in patients with advanced cancer. [ABSTRACT FROM AUTHOR]- Published
- 2018
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18. Efficacy of a brief manualized intervention Managing Cancer and Living Meaningfully (CALM) adapted to German cancer care settings: study protocol for a randomized controlled trial.
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Scheffold, Katharina, Philipp, Rebecca, Engelmann, Dorit, Schulz-Kindermann, Frank, Rosenberger, Christina, Oechsle, Karin, Härter, Martin, Wegscheider, Karl, Lordick, Florian, Lo, Chris, Hales, Sarah, Rodin, Gary, and Mehnert, Anja
- Abstract
Background: Although psycho-oncological interventions have been shown to significantly reduce symptoms of anxiety and depression and enhance quality of life, a substantial number of patients with advanced cancer do not receive psycho-oncological interventions tailored to their individual situation. Given the lack of reliable data on the efficacy of psycho-oncological interventions in palliative care settings, we aim to examine the efficacy of a brief, manualized individual psychotherapy for patients with advanced cancer: Managing Cancer and Living Meaningfully (CALM). CALM aims to reduce depression and death anxiety, to strengthen communication with health care providers, and to enhance hope and meaning in life. We adapted the intervention for German cancer care settings.Methods/design: We use a single-blinded randomized-controlled trial design with two treatment conditions: intervention group (IG, CALM) and control group (CG). Patients in the CG receive a usual non-manualized supportive psycho-oncological intervention (SPI). Patients are randomized between the IG and CG and assessed at baseline (t0), after three (t1) and after 6 months (t2). We include patients with a malignant solid tumor who have tumor stages of III or IV (UICC classification). Patients who are included in the study are at least 18 years old, speak German fluently, score greater than or equal to nine on the PHQ-9 or/and greater than or equal to five on the Distress Thermometer. It is further necessary that there is no evidence of severe cognitive impairments. We measure depression, anxiety, distress, quality of life, demoralization, symptom distress, fatigue as well as spiritual well-being, posttraumatic growth and close relationship experiences using validated questionnaires. We hypothesize that patients in the IG will show a significantly lower level of depression 6 months after baseline compared to patients in the CG. We further hypothesize a significant reduction in anxiety and fatigue as well as significant improvements in psychological and spiritual well-being, meaning and post-traumatic growth in the IG compared to CG 6 months after baseline.Discussion: Our study will contribute important statistical evidence on whether CALM can reduce depression and existential distress in a German sample of advanced and highly distressed cancer patients.Trial Registration: ClinicalTrials.gov NCT02051660. [ABSTRACT FROM AUTHOR]- Published
- 2015
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19. Perceived doctor-patient relationship and its association with demoralization in patients with advanced cancer.
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Quintero Garzón, Leonhard, Koranyi, Susan, Engelmann, Dorit, Philipp, Rebecca, Scheffold, Katharina, Schulz-Kindermann, Frank, Härter, Martin, and Mehnert, Anja
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PHYSICIAN-patient relations , *HOPELESSNESS theory of depression , *BECK Depression Inventory , *REGRESSION analysis , *HELPLESSNESS (Psychology) - Abstract
Background: Advanced diseases pose a great burden on patients and go hand in hand with existential concerns. Demoralization is considered as a syndrome of existential distress with a perceived inability to cope with loss of meaning in life and feelings of helplessness and hopelessness. Professional health care providers play an important role in providing support for patients and unfavorable conversational styles in their relationship can increase patient's distress. In this study, we examine the association between the patient's perceived relationship to health care providers and demoralization.Methods: We used baseline data of a randomized control trial intervention study for advanced cancer patients (UICC-Stage ≥ III; PHQ ≥ 9 and/or Distress-Thermometer ≥5). We used a subscale of the QUAL-EC-P for assessing doctor-patient relationship, Beck Depression Inventory-II for depressive symptoms, a modified version of the MSAS as physiological symptom checklist, and the Demoralization Scale to assess demoralization. A hierarchical regression analysis was calculated.Results: In our sample of 187 patients with stage III or IV cancer (62% women), demoralization was present in 53.4% (16% moderate demoralization; 37.4% high demoralization) of the patients. Relationship to health care provider was an independent predictor (β = -.33, t(186) = -6.70, P < .001) of demoralization.Conclusions: Our findings underline the importance of the physician-patient relationship in the context of coping with existential challenges in advanced cancer patients. Trainings on how to communicate and build a sustainable relationship with patients and their specific needs may increase the buffering effect of social support by the physicians on patient's existential distress. [ABSTRACT FROM AUTHOR]- Published
- 2018
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