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1. A PAPR correction scheme for LoRa self‐jamming waveforms

Author

Clément Demeslay, Roland Gautier, Philippe Rostaing, Angela Digulescu, Cristina Despina‐Stoian, and Gilles Burel

Subjects
internet of things, jamming, power amplifiers, software radio, waveform analysis, Telecommunication, TK5101-6720
Abstract

Abstract A LoRa self‐jamming scheme that enables secure and covert communications by adding jamming symbols when transmitting is proposed. The scheme has been validated in simulations. The work is continued by evaluating the scheme on real‐world software defined radio (SDR) equipment. Experiments immediately showed that a demodulation is impossible as the received signal is highly distorted. This comes from the fact that adding symbols at transmission actually generates high peak‐to‐average power ratio (PAPR) preventing proper waveform generation by the equipment's hardware. This paper presents a PAPR correction scheme that modifies the waveform. The properties of this modified waveform are analysed and the performances are assessed in simulations with realistic time and frequency synchronization assumption. For the ideal 0 dB PAPR corrected output, the SER performances are close to that of a legacy LoRa communication, while preserving the physical layer security capabilities of the self‐jamming scheme. It is finally shown that our PAPR correction scheme effectively recovers the self‐jamming properties on SDR devices.

Published
2024
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2. Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses

Author

Stephanie A Maynard, Philippe Rostaing, Natascha Schaefer, Olivier Gemin, Adrien Candat, Andréa Dumoulin, Carmen Villmann, Antoine Triller, and Christian G Specht

Subjects
single molecule localization microscopy, correlative light and electron microscopy, electron microscopy, hyperekplexia, oscillator mouse model, glycine receptor, Medicine, Science, Biology (General), QH301-705.5
Abstract

Precise quantitative information about the molecular architecture of synapses is essential to understanding the functional specificity and downstream signaling processes at specific populations of synapses. Glycine receptors (GlyRs) are the primary fast inhibitory neurotransmitter receptors in the spinal cord and brainstem. These inhibitory glycinergic networks crucially regulate motor and sensory processes. Thus far, the nanoscale organization of GlyRs underlying the different network specificities has not been defined. Here, we have quantitatively characterized the molecular arrangement and ultra-structure of glycinergic synapses in spinal cord tissue using quantitative super-resolution correlative light and electron microscopy. We show that endogenous GlyRs exhibit equal receptor-scaffold occupancy and constant packing densities of about 2000 GlyRs µm-2 at synapses across the spinal cord and throughout adulthood, even though ventral horn synapses have twice the total copy numbers, larger postsynaptic domains, and more convoluted morphologies than dorsal horn synapses. We demonstrate that this stereotypic molecular arrangement is maintained at glycinergic synapses in the oscillator mouse model of the neuromotor disease hyperekplexia despite a decrease in synapse size, indicating that the molecular organization of GlyRs is preserved in this hypomorph. We thus conclude that the morphology and size of inhibitory postsynaptic specializations rather than differences in GlyR packing determine the postsynaptic strength of glycinergic neurotransmission in motor and sensory spinal cord networks.

Published
2021
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3. Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors

Author

Olivier Mercey, Adel Al Jord, Philippe Rostaing, Alexia Mahuzier, Aurélien Fortoul, Amélie-Rose Boudjema, Marion Faucourt, Nathalie Spassky, and Alice Meunier

Subjects
Medicine, Science
Abstract

Abstract Reproductive and respiratory organs, along with brain ventricles, are lined by multiciliated epithelial cells (MCC) that generate cilia-powered fluid flows. MCC hijack the centrosome duplication pathway to form hundreds of centrioles and nucleate motile cilia. In these cells, the large majority of procentrioles are formed associated with partially characterized organelles called deuterosomes. We recently challenged the paradigm that deuterosomes and procentrioles are formed de novo by providing data, in brain MCC, suggesting that they are nucleated from the pre-existing centrosomal younger centriole. However, the origin of deuterosomes and procentrioles is still under debate. Here, we further question centrosome importance for deuterosome and centriole amplification. First, we provide additional data confirming that centriole amplification occurs sequentially from the centrosomal region, and that the first procentriole-loaded deuterosomes are associated with the daughter centriole or in the centrosomal centriole vicinity. Then, to further test the requirement of the centrosome in deuterosome and centriole formation, we depleted centrosomal centrioles using a Plk4 inhibitor. We reveal unexpected limited consequences in deuterosome/centriole number in absence of centrosomal centrioles. Notably, in absence of the daughter centriole only, deuterosomes are not seen associated with the mother centriole. In absence of both centrosomal centrioles, procentrioles are still amplified sequentially and with no apparent structural defects. They seem to arise from a focal region, characterized by microtubule convergence and pericentriolar material (PCM) assembly. The relevance of deuterosome association with the daughter centriole as well as the role of the PCM in the focal and sequential genesis of centrioles in absence of centrosomal centrioles are discussed.

Published
2019
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4. A Novel Scheme for Discrete and Secure LoRa Communications

Author

Clément Demeslay, Roland Gautier, Philippe Rostaing, Gilles Burel, and Anthony Fiche

Subjects
self-jamming waveforms, synchronization scheme, cross-correlation receiver, LoRa enhanced transceiver, LoRa discrete communications, LoRa privacy, Chemical technology, TP1-1185
Abstract

In this paper, we present a new LoRa transceiver scheme to ensure discrete communications secure from potential eavesdroppers by leveraging a simple and elegant spread spectrum philosophy. The scheme modifies both preamble and payload waveforms by adapting a current state-of-the-art LoRa synchronization front-end. This scheme can also be seen as a self-jamming approach. Furthermore, we introduce a new payload demodulation method that avoids the adverse effects of the traditional cross-correlation solution that would otherwise be used. Our simulation results show that the self-jamming scheme exhibits very good symbol error rate (SER) performance with a loss of just 0.5 dB for a frequency spread factor of up to 10.

Published
2022
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5. Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy.

Author

Olivier Gemin, Pablo Serna, Joseph Zamith, Nora Assendorp, Matteo Fossati, Philippe Rostaing, Antoine Triller, and Cécile Charrier

Subjects
Biology (General), QH301-705.5
Abstract

Pyramidal neurons (PNs) are covered by thousands of dendritic spines receiving excitatory synaptic inputs. The ultrastructure of dendritic spines shapes signal compartmentalization, but ultrastructural diversity is rarely taken into account in computational models of synaptic integration. Here, we developed a 3D correlative light-electron microscopy (3D-CLEM) approach allowing the analysis of specific populations of synapses in genetically defined neuronal types in intact brain circuits. We used it to reconstruct segments of basal dendrites of layer 2/3 PNs of adult mouse somatosensory cortex and quantify spine ultrastructural diversity. We found that 10% of spines were dually innervated and 38% of inhibitory synapses localized to spines. Using our morphometric data to constrain a model of synaptic signal compartmentalization, we assessed the impact of spinous versus dendritic shaft inhibition. Our results indicate that spinous inhibition is locally more efficient than shaft inhibition and that it can decouple voltage and calcium signaling, potentially impacting synaptic plasticity.

Published
2021
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6. Microglia Modulate Wiring of the Embryonic Forebrain

Author

Paola Squarzoni, Guillaume Oller, Guillaume Hoeffel, Lorena Pont-Lezica, Philippe Rostaing, Donovan Low, Alain Bessis, Florent Ginhoux, and Sonia Garel

Subjects
Biology (General), QH301-705.5
Abstract

Dysfunction of microglia, the tissue macrophages of the brain, has been associated with the etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to regulate neurogenesis and synaptic maturation at perinatal and postnatal stages. However, microglia invade the brain during mid-embryogenesis and thus could play an earlier prenatal role. Here, we show that embryonic microglia, which display a transiently uneven distribution, regulate the wiring of forebrain circuits. Using multiple mouse models, including cell-depletion approaches and cx3cr1−/−, CR3−/−, and DAP12−/− mutants, we find that perturbing microglial activity affects the outgrowth of dopaminergic axons in the forebrain and the laminar positioning of subsets of neocortical interneurons. Since defects in both dopamine innervation and cortical networks have been linked to neuropsychiatric diseases, our study provides insights into how microglial dysfunction can impact forebrain connectivity and reveals roles for immune cells during normal assembly of brain circuits.

Published
2014
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7. Power Allocation Optimization: Linear Precoding Adapted to NB-LDPC Coded MIMO Transmission

Author

Tarek Chehade, Ludovic Collin, Philippe Rostaing, Emanuel Radoi, and Oussama Bazzi

Subjects
Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Cellular telephone services industry. Wireless telephone industry, HE9713-9715
Abstract

In multiple-input multiple-output (MIMO) transmission systems, the channel state information (CSI) at the transmitter can be used to add linear precoding to the transmitted signals in order to improve the performance and the reliability of the transmission system. This paper investigates how to properly join precoded closed-loop MIMO systems and nonbinary low density parity check (NB-LDPC). The q elements in the Galois field, GF(q), are directly mapped to q transmit symbol vectors. This allows NB-LDPC codes to perfectly fit with a MIMO precoding scheme, unlike binary LDPC codes. The new transmission model is detailed and studied for several linear precoders and various designed LDPC codes. We show that NB-LDPC codes are particularly well suited to be jointly used with precoding schemes based on the maximization of the minimum Euclidean distance (max-dmin) criterion. These results are theoretically supported by extrinsic information transfer (EXIT) analysis and are confirmed by numerical simulations.

Published
2015
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9. Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions.

Author

Jessica Arama, Anne-Cécile Boulay, Christophe Bosc, Christian Delphin, Damarys Loew, Philippe Rostaing, Edwige Amigou, Pascal Ezan, Laure Wingertsmann, Laurent Guillaud, Annie Andrieux, Christian Giaume, and Martine Cohen-Salmon

Subjects
Medicine, Science
Abstract

The BCH (BNIP2 and Cdc42GAP Homology) domain-containing protein Bmcc1/Prune2 is highly enriched in the brain and is involved in the regulation of cytoskeleton dynamics and cell survival. However, the molecular mechanisms accounting for these functions are poorly defined. Here, we have identified Bmcc1s, a novel isoform of Bmcc1 predominantly expressed in the mouse brain. In primary cultures of astrocytes and neurons, Bmcc1s localized on intermediate filaments and microtubules and interacted directly with MAP6/STOP, a microtubule-binding protein responsible for microtubule cold stability. Bmcc1s overexpression inhibited MAP6-induced microtubule cold stability by displacing MAP6 away from microtubules. It also resulted in the formation of membrane protrusions for which MAP6 was a necessary cofactor of Bmcc1s. This study identifies Bmcc1s as a new MAP6 interacting protein able to modulate MAP6-induced microtubule cold stability. Moreover, it illustrates a novel mechanism by which Bmcc1 regulates cell morphology.

Published
2012
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37. Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors

Author

Marion Faucourt, Olivier Mercey, Alexia Mahuzier, Alice Meunier, Aurélien Fortoul, Amelie-Rose Boudjema, Nathalie Spassky, Adel Al Jord, Philippe Rostaing, Virologie et Immunologie Moléculaire, Faculté des Sciences Pharmaceutiques, Institut National de la Recherche Agronomique (INRA)-Université Francois Rabelais [Tours], Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Regionalisation du cerveau des vertébrés - Organogenèse précoce chez la souris et maladies génétiques associées, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Centriole, sports, [SDV]Life Sciences [q-bio], Science, Fluorescent Antibody Technique, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Biology, Cellular imaging, Article, 03 medical and health sciences, Procentriole, 0302 clinical medicine, Microtubule, Humans, Cilia, 030304 developmental biology, Pericentriolar material, Centrioles, Centrosome, Organelles, 0303 health sciences, Cilium, Cell Cycle, Brain, Epithelial Cells, Cell biology, Molecular Imaging, sports.league, Deuterosome, Motile cilium, Medicine, 030217 neurology & neurosurgery, Biomarkers
Abstract

International audience; Reproductive and respiratory organs, along with brain ventricles, are lined by multiciliated epithelial cells (MCC) that generate cilia-powered fluid flows. MCC hijack the centrosome duplication pathway to form hundreds of centrioles and nucleate motile cilia. In these cells, the large majority of procentrioles are formed associated with partially characterized organelles called deuterosomes. We recently challenged the paradigm that deuterosomes and procentrioles are formed de novo by providing data, in brain MCC, suggesting that they are nucleated from the pre-existing centrosomal younger centriole. However, the origin of deuterosomes and procentrioles is still under debate. Here, we further question centrosome importance for deuterosome and centriole amplification. First, we provide additional data confirming that centriole amplification occurs sequentially from the centrosomal region, and that the first procentriole-loaded deuterosomes are associated with the daughter centriole or in the centrosomal centriole vicinity. Then, to further test the requirement of the centrosome in deuterosome and centriole formation, we depleted centrosomal centrioles using a Plk4 inhibitor. We reveal unexpected limited consequences in deuterosome/centriole number in absence of centrosomal centrioles. Notably, in absence of the daughter centriole only, deuterosomes are not seen associated with the mother centriole. In absence of both centrosomal centrioles, procentrioles are still amplified sequentially and with no apparent structural defects. They seem to arise from a focal region, characterized by microtubule convergence and pericentriolar material (PCM) assembly. The relevance of deuterosome association with the daughter centriole as well as the role of the PCM in the focal and sequential genesis of centrioles in absence of centrosomal centrioles are discussed.

Published
2019
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40. NMDARs in granule cells contribute to parallel fiber–Purkinje cell synaptic plasticity and motor learning

Author

Caroline Mailhes-Hamon, Antoine Triller, Guy Bouvier, Martijn Schonewille, Annick Ayon, Chris I. De Zeeuw, Alexandra B. Nelson, Philippe Rostaing, Allison E. Girasole, Mariano Casado, and Neurosciences

Subjects
Cerebellum, Multidisciplinary, cerebellum, Chemistry, Purkinje cell, Parallel fiber, Biological Sciences, pre-NMDARs, Synapse, medicine.anatomical_structure, nervous system, Purkinje cells, nitric oxide, Postsynaptic potential, Synaptic plasticity, medicine, NMDA receptor, Motor learning, motor learning, Neuroscience
Abstract

Significance Learning depends on synaptic plasticity. The signaling mechanisms that control induction of plasticity determine the learning rules at the specific synapse involved. Moreover, the relationship between the activity patterns of synaptic inputs and the type, direction, and level of plasticity induced may evolve during development. Here, we establish a key link between receptor activation presynaptic to cerebellar Purkinje cells, downstream signaling mechanisms, and the ability of adult animals to learn a cerebellar motor task., Long-term synaptic plasticity is believed to be the cellular substrate of learning and memory. Synaptic plasticity rules are defined by the specific complement of receptors at the synapse and the associated downstream signaling mechanisms. In young rodents, at the cerebellar synapse between granule cells (GC) and Purkinje cells (PC), bidirectional plasticity is shaped by the balance between transcellular nitric oxide (NO) driven by presynaptic N-methyl-D-aspartate receptor (NMDAR) activation and postsynaptic calcium dynamics. However, the role and the location of NMDAR activation in these pathways is still debated in mature animals. Here, we show in adult rodents that NMDARs are present and functional in presynaptic terminals where their activation triggers NO signaling. In addition, we find that selective genetic deletion of presynaptic, but not postsynaptic, NMDARs prevents synaptic plasticity at parallel fiber-PC (PF-PC) synapses. Consistent with this finding, the selective deletion of GC NMDARs affects adaptation of the vestibulo-ocular reflex. Thus, NMDARs presynaptic to PCs are required for bidirectional synaptic plasticity and cerebellar motor learning.

Published
2021
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41. Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses

Author

Philippe Rostaing, Andréa Dumoulin, Olivier Gemin, Antoine Triller, Carmen Villmann, Christian G. Specht, Stephanie A Maynard, Natascha Schaefer, and Adrien Candat

Subjects
Mouse, QH301-705.5, Science, Neurotransmission, Biology, Inhibitory postsynaptic potential, Synapse, Mice, Receptors, Glycine, Postsynaptic potential, medicine, Animals, correlative light and electron microscopy, Hyperekplexia, Biology (General), Glycine receptor, oscillator mouse model, electron microscopy, Molecular Structure, spinal cord, Spinal cord, medicine.anatomical_structure, hyperekplexia, Synapses, Medicine, Brainstem, single molecule localization microscopy, glycine receptor, medicine.symptom, Neuroscience, Research Article
Abstract

Precise quantitative information about the molecular architecture of synapses is essential to understanding the functional specificity and downstream signaling processes at specific populations of synapses. Glycine receptors (GlyRs) are the primary fast inhibitory neurotransmitter receptors in the spinal cord and brainstem. These inhibitory glycinergic networks crucially regulate motor and sensory processes. Thus far the nanoscale organization of GlyRs underlying the different network specificities has not been defined. Here, we have quantitatively characterized the molecular arrangement and ultra-structure of glycinergic synapses in spinal cord tissue using quantitative super-resolution correlative light and electron microscopy (SR-CLEM). We show that endogenous GlyRs exhibit equal receptor-scaffold occupancy and constant packing densities of about 2000 GlyRs μm-2 at synapses across the spinal cord and throughout adulthood, even though ventral horn synapses have twice the total copy numbers, larger postsynaptic domains and more convoluted morphologies than dorsal horn synapses. We demonstrate that this stereotypic molecular arrangement is maintained at glycinergic synapses in the oscillator mouse model of the neuromotor disease hyperekplexia despite a decrease in synapse size, indicating that the molecular organization of GlyRs is preserved in this hypomorph. We thus conclude that the morphology and size of inhibitory postsynaptic specializations rather than differences in GlyR packing determine the postsynaptic strength of glycinergic neurotransmission in motor and sensory spinal cord networks.

Published
2021
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42. NMDARs in Granule Cells contribute to parallel fiber - Purkinje cell synaptic plasticity and motor learning

Author

Guy Bouvier, Antoine Triller, Philippe Rostaing, Martijn Schonewille, Alexandra B. Nelson, Annick Ayon, Caroline Mailhes-Hamon, Allison E. Girasole, Mariano Casado, and Chris I. De Zeeuw

Subjects
Synapse, medicine.anatomical_structure, nervous system, Postsynaptic potential, Synaptic plasticity, Purkinje cell, medicine, NMDA receptor, Parallel fiber, Biology, Motor learning, Receptor, Neuroscience
Abstract

Long-term synaptic plasticity is believed to be the cellular substrate of learning and memory. Synaptic plasticity rules are defined by the specific complement of receptors at the synapse and the associated downstream signaling mechanisms. In young rodents, at the cerebellar synapse between granule cells (GC) and Purkinje cells (PC), bidirectional plasticity is shaped by the balance between transcellular nitric oxide (NO) driven by presynaptic NMDA receptor (NMDAR) activation and postsynaptic calcium dynamics. However, the role and the location of NMDAR activation in these pathways is still debated in mature animals. Here, we show in adult rodents that NMDARs are present and functional in presynaptic terminals where their activation triggers nitric oxide signaling. In addition, we find that selective genetic deletion of presynaptic, but not postsynaptic, NMDARs prevents synaptic plasticity at parallel fiber-Purkinje cell (PF-PC) synapses. Consistent with this finding, the selective deletion of GCs NMDARs affects adaptation of the vestibulo-ocular reflex. Thus, NMDARs presynaptic to PCs are required for bidirectional synaptic plasticity and cerebellar motor learning.Significance StatementLearning depends on synaptic plasticity. The signaling mechanisms that control induction of plasticity determine the learning rules at the specific synapse involved. Moreover, the relationship between the activity patterns of synaptic inputs and the type, direction, and level of plasticity induced may evolve during development. Here, we establish a key link between NMDA receptor activation presynaptic to cerebellar Purkinje cells, downstream signaling mechanisms, and the ability of adult animals to learn a cerebellar motor task.

Published
2021
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43. Morphologically constrained modeling of spinous inhibition in the somato-sensory cortex

Author

Olivier Gemin, Matteo Fossati, Pablo Serna, Nora Assendorp, Antoine Triller, Cécile Charrier, and Philippe Rostaing

Subjects
medicine.anatomical_structure, Dendritic spine, Synaptic plasticity, Excitatory postsynaptic potential, medicine, Ultrastructure, Sensory cortex, Compartmentalization (psychology), Biology, Somatosensory system, Neuroscience, Calcium signaling
Abstract

Pyramidal neurons are covered by thousands of dendritic spines receiving excitatory synaptic inputs. The ultrastructure of dendritic spines shapes signal compartmentalization but ultrastructural diversity is rarely taken into account in computational models of synaptic integration. Here, we developed a 3D correlative light-electron microscopy (3D-CLEM) approach allowing the analysis of specific populations of synapses in genetically defined neuronal types in intact brain circuits. We used it to reconstruct segments of basal dendrites of layer 2/3 pyramidal neurons of adult mouse somatosensory cortex and quantify spine ultrastructural diversity. We found that 10% of spines were dually-innervated and 38% of inhibitory synapses localized to spines. Using our morphometric data to constrain a model of synaptic signal compartmentalization, we assessed the impact of spinous versus dendritic shaft inhibition. Our results indicate that spinous inhibition is locally more efficient than shaft inhibition and that it can decouple voltage and calcium signaling, potentially impacting synaptic plasticity.

Published
2020
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44. NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning

Author

M. (martijn) Schonewille, Allison E. Girasole, Philippe Rostaing, Caroline Mailhes-Hamon, Annick Ayon, Alexandra B. Nelson, Antoine Triller, Mariano Casado, C.I. (Chris) de Zeeuw, Guy Bouvier, M. (martijn) Schonewille, Allison E. Girasole, Philippe Rostaing, Caroline Mailhes-Hamon, Annick Ayon, Alexandra B. Nelson, Antoine Triller, Mariano Casado, C.I. (Chris) de Zeeuw, and Guy Bouvier

Abstract

Long-term synaptic plasticity is believed to be the cellular substrate of learning and memory. Synaptic plasticity rules are defined by the specific complement of receptors at the synapse and the associated downstream signaling mechanisms. In young rodents, at the cerebellar synapse between granule cells (GC) and Purkinje cells (PC), bidirectional plasticity is shaped by the balance between transcellular nitric oxide (NO) driven by presynaptic N-methyl-D-aspartate receptor (NMDAR) activation and postsynaptic calcium dynamics. However, the role and the location of NMDAR activation in these pathways is still debated in mature animals. Here, we show in adult rodents that NMDARs are present and functional in presynaptic terminals where their activation triggers NO signaling. In addition, we find that selective genetic deletion of presynaptic, but not postsynaptic, NMDARs prevents synaptic plasticity at parallel fiber-PC (PF-PC) synapses. Consistent with this finding, the selective deletion of GC NMDARs affects adaptation of the vestibulo-ocular reflex. Thus, NMDARs presynaptic to PCs are required for bidirectional synaptic plasticity and cerebellar motor learning.

Published
2021
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45. Massive centriole production can occur in the absence of deuterosomes in multiciliated cells

Author

Olivier Mercey, Alice Meunier, Eva J. Brotslaw, Michelle S. Levine, Andrew J. Holland, Brian J. Mitchell, Nathalie Spassky, Philippe Rostaing, Abhijay Kumar, Gina M. LoMastro, Valerie Gomez, Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), The Open University [Milton Keynes] (OU), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Virologie et Immunologie Moléculaire, Faculté des Sciences Pharmaceutiques, Institut National de la Recherche Agronomique (INRA)-Université Francois Rabelais [Tours], and École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Centriole, [SDV]Life Sciences [q-bio], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Biology, Article, 03 medical and health sciences, Mice, Xenopus laevis, 0302 clinical medicine, Organelle, Basal body, Animals, Humans, Cilia, Multiciliogenesis, Process (anatomy), Cells, Cultured, 030304 developmental biology, Centrioles, 0303 health sciences, Extramural, Cell Biology, Cell biology, Mice, Inbred C57BL, HEK293 Cells, 030220 oncology & carcinogenesis, Motile cilium
Abstract

International audience; Multiciliated cells (MCCs) amplify large numbers of centrioles that convert into basal bodies, which are required for producing multiple motile cilia. Most centrioles amplified by MCCs grow on the surface of organelles called deuterosomes, whereas a smaller number grow through the centriolar pathway in association with the two parent centrioles. Here, we show that MCCs lacking deuterosomes amplify the correct number of centrioles with normal step-wise kinetics. This is achieved through a massive production of centrioles on the surface and in the vicinity of parent centrioles. Therefore, deuterosomes may have evolved to relieve, rather than supplement, the centriolar pathway during multiciliogenesis. Remarkably, MCCs lacking parent centrioles and deuterosomes also amplify the appropriate number of centrioles inside a cloud of pericentriolar and fibrogranular material. These data show that the centriole number is set independently of their nucleation platforms and suggest that massive centriole production in MCCs is a robust process that can self-organize.

Published
2019
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46. Optimization of linear MIMO precoding assuming MMSE-based turbo equalization

Author

Philippe Rostaing, Nhat-Quang Nhan, L. Collin, Karine Amis, Emanuel Radoi, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Département Signal et Communications (IMT Atlantique - SC), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Lab-STICC_UBO_CACS_COM, Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université de Brest (UBO)-Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), Institut Mines-Télécom [Paris] (IMT)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-Institut Mines-Télécom [Paris] (IMT)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance ( Lab-STICC ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Département Signal et Communications ( SC ), IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -Université Bretagne Loire ( UBL ) -IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ) -École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -Université Bretagne Loire ( UBL ) -IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -Université Bretagne Loire ( UBL ) -IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)

Subjects
Computer science, MIMO, Equalization (audio), Data_CODINGANDINFORMATIONTHEORY, 02 engineering and technology, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, Precoding, [ INFO.INFO-IT ] Computer Science [cs]/Information Theory [cs.IT], 0203 mechanical engineering, Artificial Intelligence, 0202 electrical engineering, electronic engineering, information engineering, Forward error correction, Electrical and Electronic Engineering, ComputingMilieux_MISCELLANEOUS, Computer Science::Information Theory, Minimum mean square error, Applied Mathematics, 020206 networking & telecommunications, 020302 automobile design & engineering, Computational Theory and Mathematics, Single antenna interference cancellation, Channel state information, [INFO.INFO-IT]Computer Science [cs]/Information Theory [cs.IT], Signal Processing, Computer Vision and Pattern Recognition, Statistics, Probability and Uncertainty, Algorithm, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Decoding methods
Abstract

In this paper, we focus on the optimization of a linear multiple-input multiple-output (MIMO) precoder assuming an outer forward error correction code and an iterative minimum mean square error (MMSE)-based interference cancellation (turbo equalization) at the receiver side. Given perfect channel state information at both sides of the communication, we propose a novel precoder that is specifically designed to use with turbo equalization. In contrast to the conventional precoders that maximize the mutual information (MI) between finite alphabet input and the corresponding output over the precoded MIMO channel, the proposed precoder aims to maximize the MI between the finite alphabet input and the corresponding output of the equalizer. The precoder is targeted for applications that require low complexity, where forward error correction (FEC) codes with low-complex encoding and decoding structures are used. Simulation results show the error-rate performance gain of the resulting precoder compared to two other reference precoders presented in the literature, which are derived from the maximization of the precoded MIMO channel MI.

Published
2018
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47. Ultrastructure and Membrane Traffic During Cell Division in the Marine Pennate Diatom Phaeodactylum tricornutum

Author

Anton Montsant, Atsuko Tanaka, Chris Bowler, Benjamin Mathieu, Alessandra De Martino, Philippe Rostaing, Alberto Amato, and Leila Tirichine

Subjects
0106 biological sciences, Cell division, contractile ring, cytokinesis, macromolecular substances, 01 natural sciences, Microbiology, 03 medical and health sciences, symbols.namesake, Microscopy, Electron, Transmission, Sec4, Cleavage furrow, Phaeodactylum tricornutum, Actin, 030304 developmental biology, Diatoms, Original Paper, 0303 health sciences, Organisms, Genetically Modified, biology, Algal Proteins, Cell Membrane, fungi, Diatom, Cell cycle, Golgi apparatus, biology.organism_classification, Cell biology, Vesicular transport protein, Protein Transport, symbols, Syntaxin, actin, Cytokinesis, 010606 plant biology & botany
Abstract

The marine pennate diatom Phaeodactylum tricornutum has become a model for diatom biology, due to its ease of culture and accessibility to reverse genetics approaches. While several features underlying the molecular mechanisms of cell division have been described, morphological analyses are less advanced than they are in other diatoms. We therefore examined cell ultrastructure changes prior to and during cytokinesis. Following chloroplast division, cleavage furrows are formed at both longitudinal ends of the cell and are accompanied by significant vesicle transport. Although neither spindle nor microtubules were observed, the nucleus appeared to be split by the furrow after duplication of the Golgi apparatus. Finally, centripetal cytokinesis was completed by fusion of the furrows. Additionally, F-actin formed a ring structure and its diameter became smaller, accompanying the ingrowing furrows. To further analyse vesicular transport during cytokinesis, we generated transgenic cells expressing yellow fluorescent protein (YFP) fusions with putative diatom orthologs of small GTPase Sec4 and t-SNARE protein SyntaxinA. Time-lapse observations revealed that SyntaxinA-YFP localization expands from both cell tips toward the center, whereas Sec4-YFP was found in the Golgi and subsequently relocalizes to the future division plane. This work provides fundamental new information about cell replication processes in P. tricornutum.

Published
2015
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48. Precoded MIMO Systems with Non-Binary LDPC Codes and Many-to-One Mapping

Author

Philippe Rostaing, Yahong Rosa Zheng, Emanuel Radoi, Nhat-Quang Nhan, Karine Amis, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Département Signal et Communications (IMT Atlantique - SC), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Lab-STICC_UBO_CACS_COM, Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université de Brest (UBO)-Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), Institut Mines-Télécom [Paris] (IMT)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-Institut Mines-Télécom [Paris] (IMT)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Missouri University of Science and Technology (Missouri S&T), and University of Missouri System

Subjects
Computer Networks and Communications, Computer science, 05 social sciences, MIMO, Aerospace Engineering, 050801 communication & media studies, 020206 networking & telecommunications, Data_CODINGANDINFORMATIONTHEORY, 02 engineering and technology, Precoding, 0508 media and communications, Modulation, [INFO.INFO-IT]Computer Science [cs]/Information Theory [cs.IT], Automotive Engineering, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering, Low-density parity-check code, Encoder, Algorithm, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Quadrature amplitude modulation, ComputingMilieux_MISCELLANEOUS, Computer Science::Information Theory, Parity bit
Abstract

A precoding design is proposed for multiple-input multiple-output (MIMO) systems utilizing nonbinary low-density parity check (NB-LDPC) codes and many-to-one mapping. When a high-order modulation scheme is used, many-to-one mapping converts a group of low-order Galois field (GF) coded symbols into one modulated MIMO symbol vector. In contrast, one-to-one mapping maps a high-order modulation symbol directly from one high-order GF coded symbol. With the help of an interleaver between the NB-LDPC encoder and the GF to MIMO symbol mapper, the many-to-one mapping enables turbo receiver and reduces the computational complexity by more than 95%. The proposed MIMO precoders enhance the error-rate performance of the many-to-one NB-LDPC MIMO system, especially in terms of reducing the error floor and improving the waterfall region. The proposed precoder design modifies the approach that suboptimally maximizes the minimal Euclidean distance between the received MIMO symbols. Simulation results show that the proposed precoders enhance the robustness of the precoder design and reduce the inner and outer iterations of the turbo receiver.

Published
2017
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49. Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin

Author

I. Lorena Arancibia-Carcamo, Andrew F. MacAskill, Alison E. Twelvetrees, Frédéric Saudou, Josef T. Kittler, Zhen Yan, Michael J. Lumb, Antoine Triller, Eunice Y. Yuen, Philippe Rostaing, and Sandrine Humbert

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Patch-Clamp Techniques, Huntingtin, Neuroscience(all), HUMDISEASE, Kinesins, Nerve Tissue Proteins, Biology, Neurotransmission, Inhibitory postsynaptic potential, Synaptic Transmission, Article, MOLNEURO, Rats, Sprague-Dawley, mental disorders, Animals, Humans, Protein Isoforms, Nuclear protein, Cells, Cultured, Neurons, Huntingtin Protein, GABAA receptor, General Neuroscience, Cell Membrane, Nuclear Proteins, Receptors, GABA-A, Rats, nervous system diseases, Cell biology, Huntington Disease, nervous system, Synapses, Axoplasmic transport, NMDA receptor, Kinesin, CELLBIO, Peptides, Neuroscience
Abstract

Summary The density of GABA A receptors (GABA A Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington's disease, which is caused by a polyglutamine repeat in the protein huntingtin. However, the machinery that delivers GABA A Rs to synapses is unknown. We demonstrate that GABA A Rs are trafficked to synapses by the kinesin family motor protein 5 (KIF5). We identify the adaptor linking the receptors to KIF5 as the huntingtin-associated protein 1 (HAP1). Disrupting the HAP1-KIF5 complex decreases synaptic GABA A R number and reduces the amplitude of inhibitory postsynaptic currents. When huntingtin is mutated, as in Huntington's disease, GABA A R transport and inhibitory synaptic currents are reduced. Thus, HAP1-KIF5-dependent GABA A R trafficking is a fundamental mechanism controlling the strength of synaptic inhibition in the brain. Its disruption by mutant huntingtin may explain some of the defects in brain information processing occurring in Huntington's disease and provides a molecular target for therapeutic approaches.

Published
2010
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50. Association and Joint Optimization of max-dmin Precoder with MIMO Turbo Equalization

Author

Ludovic Collin, Karine Amis, Philippe Rostaing, Nhat-Quang Nhan, Emanuel Radoi, Lab-STICC_TB_CACS_COM, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance ( Lab-STICC ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Département Signal et Communications ( SC ), Université européenne de Bretagne ( UEB ) -Télécom Bretagne-Institut Mines-Télécom [Paris], Département Electronique - UFR Sciences et Techniques - Université de Brest, Université de Brest ( UBO ), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Département Signal et Communications (SC), Université européenne de Bretagne - European University of Brittany (UEB)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT), and Université de Brest (UBO)

Subjects
Minimum mean square error, biology, Computer science, Turbo, Transmitter, MIMO, Concatenation, 05 social sciences, Equalization (audio), 020302 automobile design & engineering, 050801 communication & media studies, 020206 networking & telecommunications, 02 engineering and technology, Data_CODINGANDINFORMATIONTHEORY, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, biology.organism_classification, 0508 media and communications, 0203 mechanical engineering, Control theory, 0202 electrical engineering, electronic engineering, information engineering, Forward error correction, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Decoding methods, Computer Science::Information Theory
Abstract

International audience; In this paper, we investigate the concatenation of the multiple input multiple output (MIMO) max-dmin linear precoder with an outer forward error correction (FEC) code at the transmitter. At the receiver side, the turbo equalization is taken into account, which iteratively exchanges the extrinsic information between a minimum mean square error interference canceller (MMSE IC) and a FEC decoder. The analysis done by extrinsic information transfer (EXIT) chart shows that a higher mutual information (MI) at the convergence state of the turbo equalization is observed thanks to the linear precoder. In addition, we exploit this property to propose a new precoder named max-dmin-mod. Numerical simulations are in accordance with the theoretical analysis, which exhibits a significant improvement of the error-rate of the turbo equalization as well as a significant gain of max-dmin-mod compared to original max-dmin precoder.

Published
2015
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