1. Metabolism and antioxidation regulation of total flavanones from Sedum sarmentosum Bunge against high-fat diet-induced fatty liver disease in Nile tilapia (Oreochromis niloticus)
- Author
-
Kai Yu, Xiuyun Huang, Zhanyang Tang, Cuiqin Mo, Kai Huang, Linxing Pang, and Linlin Sun
- Subjects
Fish Proteins ,medicine.medical_specialty ,Normal diet ,Physiology ,Aquatic Science ,Biology ,Diet, High-Fat ,Biochemistry ,Antioxidants ,Sedum ,Fish Diseases ,03 medical and health sciences ,Nile tilapia ,Internal medicine ,medicine ,Animals ,Phospholipid metabolic process ,PPAR alpha ,Triglycerides ,Glutathione Transferase ,030304 developmental biology ,0303 health sciences ,Fatty liver ,Lipid metabolism ,Cichlids ,04 agricultural and veterinary sciences ,General Medicine ,Lipid Metabolism ,medicine.disease ,biology.organism_classification ,Fatty Liver ,PPAR gamma ,Oreochromis ,Cholesterol ,Endocrinology ,Liver ,Biosynthetic process ,Flavanones ,Hepatocytes ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,lipids (amino acids, peptides, and proteins) ,Liver function - Abstract
Diet-induced fatty liver is a considerable threaten to fish aquaculture due to the popularity of the high-fat diet (HFD) feeding. Our study aims to investigate the effects of flavanones from Sedum sarmentosum Bunge (FSSB) on the liver function to identify a potential treatment for HFD-induced fatty liver disease. Physiological and pathological indicators were tested in the liver of Nile tilapia (Oreochromis niloticus) and results showed parameters including lipid metabolites, redox parameters, and inflammatory factors could be adequately restored to normal level by addition of 150 mg/kg FSSB to HFD. Proteomics analysis was performed in liver tissues from tilapia with normal diet (ND), HFD, and HFD+FSSB. Totally, 51 upregulated proteins and 77 downregulated proteins were identified in HFD groups and 67 proteins of them were restored after treated with FSSB. Bioinformatics analysis showed that differentially expressed proteins (DEPs) in HFD+FSSB150 group compared with HFD group are mainly enriched in acety-CoA metabolic process, adenosine-triphosphate (ATP) biosynthetic process, lipid metabolic process, and phospholipid metabolic process. The dysregulated proteins were involved in peroxidosome proliferators-activated receptor (PPAR) signaling pathway, fat digestion and absorption, and immune system. The quantitative real-time PCR (qRT-PCR) assay further revealed that the expression of GST, PPARα, PPARγ, and multiple-inflammatory cytokines could be also reversed in HFD group under the treatment of 150 mg/kg FSSB. Our findings demonstrated FSSB is efficient for the treatment of fatty liver disease through regulation of lipid metabolism and antioxidation in Nile tilapia, providing a new treatment of non-alcoholic fatty liver disease (NAFLD) in fish aquaculture.
- Published
- 2021