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3. Nettle, a Long-Known Fiber Plant with New Perspectives

Author

Viotti, C., Albrecht, K., Amaducci, Stefano, Bardos, P., Bertheau, C., Blaudez, D., Bothe, L., Cazaux, D., Ferrarini, Andrea, Govilas, J., Gusovius, H. -J., Jeannin, T., Luhr, C., Mussig, J., Pilla, Marcello, Placet, V., Puschenreiter, M., Tognacchini, A., Yung, L., Chalot, M., Amaducci S. (ORCID:0000-0002-6184-9257), Ferrarini A. (ORCID:0000-0001-9390-7004), Pilla M., Viotti, C., Albrecht, K., Amaducci, Stefano, Bardos, P., Bertheau, C., Blaudez, D., Bothe, L., Cazaux, D., Ferrarini, Andrea, Govilas, J., Gusovius, H. -J., Jeannin, T., Luhr, C., Mussig, J., Pilla, Marcello, Placet, V., Puschenreiter, M., Tognacchini, A., Yung, L., Chalot, M., Amaducci S. (ORCID:0000-0002-6184-9257), Ferrarini A. (ORCID:0000-0001-9390-7004), and Pilla M.

Abstract

The stinging nettle Urtica dioica L. is a perennial crop with low fertilizer and pesticide requirements, well adapted to a wide range of environmental conditions. It has been successfully grown in most European climatic zones while also promoting local flora and fauna diversity. The cultivation of nettle could help meet the strong increase in demand for raw materials based on plant fibers as a substitute for artificial fibers in sectors as diverse as the textile and automotive industries. In the present review, we present a historical perspective of selection, harvest, and fiber processing features where the state of the art of nettle varietal selection is detailed. A synthesis of the general knowledge about its biology, adaptability, and genetics constituents, highlighting gaps in our current knowledge on interactions with other organisms, is provided. We further addressed cultivation and processing features, putting a special emphasis on harvesting systems and fiber extraction processes to improve fiber yield and quality. Various uses in industrial processes and notably for the restoration of marginal lands and avenues of future research on this high-value multi-use plant for the global fiber market are described.

Published
2022

4. Impact of chronic exposure to 5-alpha reductase inhibitors on the risk of hospitalization for COVID-19: A case-control study in male population from two COVID-19 regional centers of Lombardy, Italy

Author

Lazzeri, M., Duga, S., Azzolini, E., Fasulo, V., Buffi, N., Saita, A., Lughezzani, G., Paraboschi, E. M., Hurle, R., Nobili, A., Cecconi, M., Guazzoni, G., Casale, P., Asselta, R., Accornero, S., Aghemo, A., Alfarone, L., Ali, H., Aloise, M., Angelini, C., Arcari, I., Arosio, P., Baccarin, A., Badalamenti, S., Baggio, S., Balzarini, L., Barbagallo, M., Barberi, C., Barbic, F., Barbieri, V., Barbone, A., Basciu, A., Benvenuti, C., Bianchi, I., Bocciolone, M., Bonifacio, C., Borea, F., Borroni, M., Bresciani, G., Brunetta, E., Bulletti, C., Cadonati, C., Calabro', L., Calatroni, M., Caltagirone, G., Calvetta, A. A., Cannata, F., Canziani, L., Capogreco, A., Capretti, G. L., Carlani, E., Carrone, F., Casana, M., Castelli, A., Ceribelli, A., Ceriotti, C., Ciccarelli, M. C., Cimino, M., Citterio, G., Ciuffini, L., Colaizzi, C., Colapiet-Ro, F., Costa, G., Cozzi, O., Craviotto, V., Crespi, C., Crippa, M., D'Antuono, F., D'Orazio, F., Da Rio, L., Dal Farra, S., D'Antonio, F., De Ambroggi, G., De Donato, M., De Lucia, F., De Nittis, P., De Santis, M., Delle Rose, G., Desai, A., Di Pilla, M., Dipaola, F., Dipasquale, A., Droandi, G., Altieri, V., Fazio, R., Fedeli, C., Ferrante, G., Ferrara, E. C., Ferrari, M. C., Ferri, S., Folci, M., Foresti, S., Franchi, E., Fraolini, E., Furfaro, F., Galimberti, P., Galtieri, A., Gavazzi, F., and Generali, E.

Subjects
Male, SARS-CoV-2, Urology, COVID-19, Middle Aged, 5-alpha reductase inhibitors, Androgens, Sex, Hospitalization, Nephrology, Case-Control Studies, Humans, Female, Aged
Abstract

There are sex differences in vulnerability to Coronavirus disease 2019 (COVID-19). The coronavirus S protein mediates viral entry into target cells employing the host cellular serine protease TMPRSS2 for S-protein priming. The TMPRSS2 gene expression is responsive to androgen stimulation and it could partially explain sex differences. We hypothesized that men chronically exposed to 5-alpha reductase inhibitors (5ARIs) for benign prostate hyperplasia (BPH) have a lower risk of hospitalization for COVID-19.This is a population-based case-control study on consecutive patients positive for SARS-CoV-2 virus who required hospitalization for COVID-19 (cases), age-matched to beneficiaries of the Lombardy Regional Health Service (controls). Data were collected by two high-volume COVID-19 regional centers of Lombardy (Italy). The primary outcome was to compare the prevalence of patients chronically exposed to 5ARIs, who required hospitalization for COVID-19, with the one of controls.Overall, 943 males were enrolled; 45 (4.77%) were exposed to 5ARI. COVID-19 patients aged55 years under 5ARI treatment were significantly less than expected on the basis of the prevalence of 5ARI treatment among age-matched controls (5.57 vs. 8.14%; P=0.0083, 95% CI: 0.75-3.97%). This disproportion was higher for men aged65 (7.14 vs. 12.31%; P=0.0001, 95% CI: 2.83-6.97%). Eighteen 5ARIs-patients died; the mean age of men who died was higher than those who did not: 75.98±9.29 vs. 64.78±13.57 (P0.001). Cox-regression and multivariable models did not show correlation between 5ARIs exposure and protection against intensive care unit admission/death.Men exposed to 5ARIs might be less vulnerable to severe COVID-19, supporting its use in disease prophylaxis.

Published
2022

10. Association Between Lifestyle and Systemic Arterial Hypertension in Young Adults: A National, Survey-Based, Cross-Sectional Study

Author

Bruno, R, Pucci, G, Rosticci, M, Guarino, L, Guglielmo, C, Rosei, C, Monticone, S, Giavarini, A, Lonati, C, Torlasco, C, Fedecostante, M, Manzi, M, Pezzutto, F, Di Pilla, M, Artom, N, Battistoni, A, Pignatelli, G, Sanga, V, Pengo, M, Bruno RM, Pucci G, Rosticci M, Guarino L, Guglielmo C, Rosei CA, Monticone S, Giavarini A, Lonati C, Torlasco C, Fedecostante M, Manzi MV, Pezzutto F, Di Pilla M, Artom N, Battistoni A, Pignatelli G, Sanga V, Pengo M, Bruno, R, Pucci, G, Rosticci, M, Guarino, L, Guglielmo, C, Rosei, C, Monticone, S, Giavarini, A, Lonati, C, Torlasco, C, Fedecostante, M, Manzi, M, Pezzutto, F, Di Pilla, M, Artom, N, Battistoni, A, Pignatelli, G, Sanga, V, Pengo, M, Bruno RM, Pucci G, Rosticci M, Guarino L, Guglielmo C, Rosei CA, Monticone S, Giavarini A, Lonati C, Torlasco C, Fedecostante M, Manzi MV, Pezzutto F, Di Pilla M, Artom N, Battistoni A, Pignatelli G, Sanga V, and Pengo M

Abstract

Introduction: The prevalence of systemic arterial hypertension in young adults is increasing worldwide in association with modifiable risk factors. Aim: To assess the prevalence of high blood pressure (BP) in young adults participating to a screening campaign during the World Hypertension Day (17/05/2014), and to determine the possible association with lifestyle factors. Methods: 493 individuals aged 18–35 years were selected in 13 Italian cities. All participants underwent BP measurement together with the administration of a questionnaire exploring: medical and drug history; traditional cardiovascular risk factors and diseases; dietary pattern; salt intake; sleep habits; mood disorders. Results: High BP (≥140/90 mmHg) was found in 54 individuals, with a prevalence of 11 % and awareness of 28 %. Those with high BP values were more frequently men, reported a higher BMI and a greater use of corticosteroids and non-steroidal anti-inflammatory drugs, and had a lower anxiety score. Concerning dietary habits, they were more likely to eat cheese/cold cuts ≥3 times/week, to have their meals out ≥1/day and to eat in fast foods ≥1/week. In the multiple logistic regression analysis, male sex [OR 3.19, 95 % CI (1.33–7.63)], BMI [OR 1.14 95 % CI (1.04–1.25)], eating in fast foods [OR 3.10 95 % CI (1.21–7.95)], and anxiety [OR 0.85 95 % CI (0.75–0.97)], were independently associated with high BP. Conclusions: High BP values were found in 11 % young adults. Male sex, adiposity and alimentary habits were the main determinants of high BP values, indicating that young men are a suitable target for healthy lifestyle interventions.

Published
2016

13. IMPACT OF SEASONALITY AND AIR POLLUTANTS ON WAVE REFLECTION IN HYPERTENSIVE PATIENTS

Author

Di Pilla, M., Bruno, R.M., Ghiadoni, L., Stea, F., Massetti, L., Bertolozzi, I., Taddei, S., and Modesti, P.A.

Subjects
hypertension, air pollution
Abstract

Objective: Important climate-related variations of clinic and ambulatory blood pressure (BP) have been repeatedly reported. However, the influence of seasonality and other environmental factors such as air pollutants and outdoor temperature on wave reflection, a parameter associated with increased risk of cardiovascular events, has never been investigated. The aim of the present study was to examine in a cross-sectional survey whether acute variations in these environmental factors may affect wave reflection, measured as augmentation pressure (AP) and augmentation index normalized at a heart rate of 75bpm (AIx75).

Published
2016
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16. [PP.19.25] INCREASED CENTRAL PRESSURE AUGMENTATION IS ASSOCIATED WITH REDUCED SLEEP DURATION IN INDIVIDUALS EXPOSED TO AIRCRAFT NOISE POLLUTION

Author

Bruno, R., primary, Faraguna, U., additional, Di Pilla, M., additional, Di Galante, M., additional, Banfi, T., additional, Gemignani, A., additional, Fidecaro, F., additional, Licitra, G., additional, Bonanni, E., additional, Berrettini, S., additional, Vigotti, M.A., additional, Taddei, S., additional, and Ghiadoni, L., additional

Published
2017
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23. [OP.5B.08] IMPACT OF SEASONALITY AND AIR POLLUTANTS ON CAROTID-FEMORAL PULSE WAVE VELOCITY IN HYPERTENSIVE PATIENTS

Author

Lorenzo Ghiadoni, Di Pilla M, Francesco Stea, Luciano Massetti, Rosa-Maria Bruno, Pietro Amedeo Modesti, Stefano Taddei, and Iacopo Bertolozzi

Subjects
Physiology, business.industry, pulse wave velocity, air pollution, 030204 cardiovascular system & hematology, Seasonality, medicine.disease, Atmospheric sciences, 03 medical and health sciences, 0302 clinical medicine, Air pollutants, Internal Medicine, Medicine, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Pulse wave velocity
Published
2016
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26. Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir

Author

Monini, P, Sgadari, C, Grosso, M, Bellino, S, Di Biagio, A, Toschi, E, Bacigalupo, I, Sabbatucci, M, Cencioni, G, Salvi, E, Leone, P, Ensoli, B, Barillari, G, Moracci, G, Carratelli, L, Gatti, G, Brambilla, L, Brambati, M, Ferrucci, S, De Pita, O, Pilla, M, Di Carlo, A, Giuliani, M, Cottoni, F, Cuccuru, M, Calvieri, S, Clerico, R, Potenza, C, Tirelli, U, Simonelli, C, Martellotta, F, Strumia, R, Borghi, A, Del Giacco, S, Moi, L, Piludu, G, Sirianni, M, Campagna, M, Sarmati, L, Andreoni, M, Bianchini, G, Sheldon, J, Milzer, J, and Schulz, T

Subjects
Aged, Aged, 80 and over, Antibodies, Viral, Antineoplastic Agents, Biomarkers, Tumor, HIV Protease Inhibitors, HIV Seronegativity, Herpesvirus 8, Human, Humans, Indinavir, Middle Aged, Sarcoma, Kaposi, Treatment Outcome, Settore MED/09 - Medicina Interna, Settore MED/17 - Malattie Infettive, Immunology, Kaposi, Biology, Virus, Antibodies, Acquired immunodeficiency syndrome (AIDS), medicine, 80 and over, Immunology and Allergy, HIV Protease Inhibitor, Protease inhibitor (pharmacology), Viral, Herpesvirus 8, Kaposi's sarcoma, Tumor, virus diseases, Sarcoma, Settore MED/07 - Microbiologia e Microbiologia Clinica, medicine.disease, biology.organism_classification, Infectious Diseases, Lentivirus, Biomarkers, medicine.drug, Human
Abstract

HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.

Published
2009

27. ATTUALITA' IN TEMA DI ORTICARIA DA FREDDO

Author

Canci, C., Pilla, M. A., Viviano, M. T., Finaldi, C., Faiola, R., Curatolo, Pietro, Tammaro, Antonella, Giustini, S., and Panasiti, Giuseppe

Published
1999

48. Gate-recessed integrated E/D GaN HEMT technology with fT/fmax >300 GHz.

Author

Schuette, M. L., Ketterson, A., Bo Song, Beam, E., Tso-Min Chou, Pilla, M., Hua-Quen Tserng, Xiang Gao, Shiping Guo, Fay, P. J., Xing, H. G., and Saunier, P.

Subjects
MODULATION-doped field-effect transistors, BREAKDOWN voltage, ALUMINUM nitride, GALLIUM nitride, OHMIC contacts
Abstract

We report 1000-transistor-level monolithic circuit integration of sub-30-nm gate-recessed E/D GaN high-electron-mobility transistors with fT and fmax above 300 GHz. Simultaneous fT/fmax of 348/340 and 302/301 GHz for E- and D-mode devices, respectively, was measured, representing a 58% increase in fT compared with our previous report, due to improved management of RC parasitic delay. Three-terminal E- and D-mode breakdown voltage of 10.7 and 11.8 V, respectively, is limited by gate-drain breakdown. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Increased prevalence of diabetes mellitus in bullous pemphigoid patients during the last decade.

Author

Fania, L., Di Zenzo, G., Didona, B., Pilla, M. A., Sobrino, L., Panebianco, A., Mazzanti, C., and Abeni, D.

Subjects
BULLOUS pemphigoid, AUTOANTIBODIES, COLLAGEN, DIABETES, CD26 antigen
Abstract

The article talks about bullous pemphigoid (BP) is a major autoimmune blistering skin disorder. It is mentioned that in BP majority of the autoantibodies (autoAbs) target the juxtamembranous extracellular NC16A domain of hemidesmosomal collagen XVII (COL17). The article discusses the connection between between BP and diabetes mellitus (DM) and how Dipeptidyl peptidase (DPP)-IV inhibitors causes BP.

Published
2018
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