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1. Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk

Author

Berciano José, Valdivieso Fernando, Frank-García Ana, Dobato José L, Calero Miguel, Pozueta Ana, Rodríguez-Rodríguez Eloy, Sánchez-Juan Pascual, Mateo Ignacio, Vázquez-Higuera José L, Bullido Maria J, and Combarros Onofre

Subjects
Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases. Methods In a group of 729 Spanish late-onset Alzheimer's disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau protein phosphatase-2A (PP2A) pathway, to address hypotheses of genetic variation that might influence AD risk. Results There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele. Conclusion Our negative findings in the Spanish population argue against the hypothesis that genetic variation in the tau protein phosphatase-2A (PP2A) pathway is causally related to AD risk

Published
2011
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2. Detection of early Alzheimer's disease in MCI patients by the combination of MMSE and an episodic memory test

Author

Berciano José, González-Perez Soraya, Sánchez-Juan Pascual, Mateo Ignacio, Vazquez-Higuera José, Rodríguez-Rodríguez Eloy, Pozueta Ana, and Combarros Onofre

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Mild cognitive impairment (MCI) is a heterogeneous clinical entity that comprises the prodromal phase of Alzheimer's disease (Pr-AD). New biomarkers are useful in detecting Pr-AD, but they are not universally available. We aimed to investigate baseline clinical and neuropsychological variables that might predict progression from MCI to AD dementia. Methods All patients underwent a complete clinical and neuropsychological evaluation at baseline and every 6 months during a two-year follow-up period, with 54 out of 109 MCI patients progressing to dementia (50 of them progressed to AD dementia), and 55 remaining as stable MCI (S-MCI). Results A combination of MMSE and California Verbal Learning Test Long Delayed Total Recall (CVLT-LDTR) constituted the best predictive model: subjects scoring above 26/30 on MMSE and 4/16 on CVLT-LDTR had a negative predictive value of 93.93% at 2 years, whereas those subjects scoring below both of these cut-off scores had a positive predictive value of 80.95%. Conclusions Pr-AD might be distinguished from S-MCI at baseline using the combination of MMSE and CVLT-LDTR. These two neuropsychological predictors are relatively brief and may be readily completed in non-specialist clinical settings.

Published
2011
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3. Caspase-1 genetic variation is not associated with Alzheimer's disease risk

Author

Berciano José, Valdivieso Fernando, Frank Ana, Martínez-García Ana, Pozueta Ana, Mateo Ignacio, Sánchez-Juan Pascual, Rodríguez-Rodríguez Eloy, Vázquez-Higuera José, Bullido María J, and Combarros Onofre

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Interleukin (IL)-1β is a potent proinflammatory cytokine markedly overexpressed in the brains of patients with Alzheimer's disease (AD), and also involved in development of atherosclerosis and coronary artery disease. Caspase-1 (CASP1), formerly called IL-1β converting enzyme (ICE), mediates the cleavage of the inactive precursor of IL-1β into the biologically active form. CASP1 genetic variation (G+7/in6A, rs501192) has been associated with susceptibility to myocardial infarction and cardiovascular death risk. We examined the contribution of this gene to the susceptibility for AD. Methods We examined genetic variations of CASP1 by genotyping haplotype tagging SNPs (htSNPs) (rs501192, rs556205 and rs530537) in a group of 628 Spanish AD cases and 722 controls. Results There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele. Conclusion Our negative findings in the Spanish population argue against the hypothesis that CASP1 genetic variations are causally related to AD risk.

Published
2010
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4. DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort

Author

Berciano José, Valdivieso Fernando, Sastre Isabel, Frank Ana, Pozueta Ana, Mateo Ignacio, Rodríguez-Rodríguez Eloy, Sánchez-Juan Pascual, Vázquez-Higuera José, Bullido María J, and Combarros Onofre

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background As dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for AD. Methods We examined genetic variations of DYRK1A by genotyping haplotype tagging SNPs (htSNPs) (rs11701483, rs2835740, rs1137600, rs2835761, rs2835762, rs2154545 and rs8132976) in a group of 634 Spanish AD cases and 733 controls. Results There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by APOE ε4 allele. Conclusion Our negative findings in the Spanish population argue against the hypothesis that DYRK1A genetic variations are causally related to AD risk. Still, additional studies using different sets of patients and control subjects deserve further attention, since supporting evidence for association between DYRK1A gene and AD risk in the Japanese population exists.

Published
2009
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5. Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

Author

Jansen, Iris E., van der Lee, Sven J., Gomez-Fonseca, Duber, de Rojas, Itziar, Dalmasso, Maria Carolina, Grenier-Boley, Benjamin, Zettergren, Anna, Mishra, Aniket, Ali, Muhammad, Andrade, Victor, Bellenguez, Céline, Kleineidam, Luca, Küçükali, Fahri, Sung, Yun Ju, Tesí, Niccolo, Vromen, Ellen M., Wightman, Douglas P., Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Amouyel, Philippe, Athanasiu, Lavinia, Bahrami, Shahram, Bailly, Henri, Belbin, Olivia, Bergh, Sverre, Bertram, Lars, Biessels, Geert Jan, Blennow, Kaj, Blesa, Rafael, Boada, Mercè, Boland, Anne, Buerger, Katharina, Carracedo, Ángel, Cervera-Carles, Laura, Chene, Geneviève, Claassen, Jurgen A. H. R., Debette, Stephanie, Deleuze, Jean-Francois, de Deyn, Peter Paul, Diehl-Schmid, Janine, Djurovic, Srdjan, Dols-Icardo, Oriol, Dufouil, Carole, Duron, Emmanuelle, Düzel, Emrah, Fladby, Tormod, Fortea, Juan, Frölich, Lutz, García-González, Pablo, Garcia-Martinez, Maria, Giegling, Ina, Goldhardt, Oliver, Gobom, Johan, Grimmer, Timo, Haapasalo, Annakaisa, Hampel, Harald, Hanon, Olivier, Hausner, Lucrezia, Heilmann-Heimbach, Stefanie, Helisalmi, Seppo, Heneka, Michael T., Hernández, Isabel, Herukka, Sanna-Kaisa, Holstege, Henne, Jarholm, Jonas, Kern, Silke, Knapskog, Anne-Brita, Koivisto, Anne M., Kornhuber, Johannes, Kuulasmaa, Teemu, Lage, Carmen, Laske, Christoph, Leinonen, Ville, Lewczuk, Piotr, Lleó, Alberto, de Munain, Adolfo López, Lopez-Garcia, Sara, Maier, Wolfgang, Marquié, Marta, Mol, Merel O., Montrreal, Laura, Moreno, Fermin, Moreno-Grau, Sonia, Nicolas, Gael, Nöthen, Markus M., Orellana, Adelina, Pålhaugen, Lene, Papma, Janne M., Pasquier, Florence, Perneczky, Robert, Peters, Oliver, Pijnenburg, Yolande A. L., Popp, Julius, Posthuma, Danielle, Pozueta, Ana, Priller, Josef, Puerta, Raquel, Quintela, Inés, Ramakers, Inez, Rodriguez-Rodriguez, Eloy, Rujescu, Dan, Saltvedt, Ingvild, Sanchez-Juan, Pascual, Scheltens, Philip, Scherbaum, Norbert, Schmid, Matthias, Schneider, Anja, Selbæk, Geir, Selnes, Per, Shadrin, Alexey, Skoog, Ingmar, Soininen, Hilkka, Tárraga, Lluís, Teipel, Stefan, Tijms, Betty, Tsolaki, Magda, Van Broeckhoven, Christine, Van Dongen, Jasper, van Swieten, John C., Vandenberghe, Rik, Vidal, Jean-Sébastien, Visser, Pieter J., Vogelgsang, Jonathan, Waern, Margda, Wagner, Michael, Wiltfang, Jens, Wittens, Mandy M. J., Zetterberg, Henrik, Zulaica, Miren, van Duijn, Cornelia M., Bjerke, Maria, Engelborghs, Sebastiaan, Jessen, Frank, Teunissen, Charlotte E., Pastor, Pau, Hiltunen, Mikko, Ingelsson, Martin, Andreassen, Ole A., Clarimón, Jordi, Sleegers, Kristel, Ruiz, Agustín, Ramirez, Alfredo, Cruchaga, Carlos, Lambert, Jean-Charles, and van der Flier, Wiesje

Published
2022
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7. The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals

Author

López-de-Eguileta, Alicia, López-García, Sara, Lage, Carmen, Pozueta, Ana, García-Martínez, María, Kazimierczak, Martha, Bravo, María, Irure, Juan, López-Hoyos, Marcos, Muñoz-Cacho, Pedro, Rodríguez-Perez, Noelia, Tordesillas-Gutiérrez, Diana, Goikoetxea, Alexander, Nebot, Claudia, Rodríguez-Rodríguez, Eloy, Casado, Alfonso, and Sánchez-Juan, Pascual

Published
2022
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8. Where Should I Draw the Line: PET-Driven, Data-Driven, or Manufacturer Cut-Off?

Author

Sánchez-Soblechero, Antonio, primary, López-García, Sara, additional, Lage, Carmen, additional, Fernández-Matarrubia, Marta, additional, Irure, Juan, additional, López-Hoyos, Marcos, additional, Jiménez-Bonilla, Julio, additional, Quirce, Remedios, additional, de Arcocha-Torres, María, additional, Cuenca-Vera, Oriana, additional, Martín-Arroyo, Juan, additional, Martínez-Dubarbie, Francisco, additional, Pozueta, Ana, additional, García-Martínez, María, additional, Infante, Jon, additional, Sánchez-Juan, Pascual, additional, and Rodríguez-Rodríguez, Eloy, additional

Published
2024
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9. A snake that bites its own tail. Acquisition and loss of concepts in children and semantic dementia patients through the analysis of drawings

Author

Pozueta, Ana, Lage, Carmen, García-Martínez, María, Kazimierczak, Martha, Bravo, María, López-García, Sara, Fernández-Rodríguez, Andrea, Riancho, Javier, González-Suárez, Andrea, Vázquez-Higuera, José Luis, Cano-Abascal, Ángel, Martínez-Dubarbie, Francisco, de Arcocha-Torres, María, Jiménez-Bonilla, Julio, Banzo, Ignacio, Rodríguez-Rodríguez, Eloy, and Sánchez-Juan, Pascual

Published
2020
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12. Cortical microstructural changes along the Alzheimer's disease continuum

Author

Montal, Victor, Vilaplana, Eduard, Alcolea, Daniel, Pegueroles, Jordi, Pasternak, Ofer, González-Ortiz, Sofia, Clarimón, Jordi, Carmona-Iragui, María, Illán-Gala, Ignacio, Morenas-Rodríguez, Estrella, Ribosa-Nogué, Roser, Sala, Isabel, Sánchez-Saudinós, María-Belén, García-Sebastian, Maite, Villanúa, Jorge, Izagirre, Andrea, Estanga, Ainara, Ecay-Torres, Mirian, Iriondo, Ane, Clerigue, Montserrat, Tainta, Mikel, Pozueta, Ana, González, Andrea, Martínez-Heras, Eloy, Llufriu, Sara, Blesa, Rafael, Sanchez-Juan, Pascual, Martínez-Lage, Pablo, Lleó, Alberto, and Fortea, Juan

Published
2018
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13. Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

Author

Alcolea, Daniel, Vilaplana, Eduard, Pegueroles, Jordi, Montal, Victor, Sánchez-Juan, Pascual, González-Suárez, Andrea, Pozueta, Ana, Rodríguez-Rodríguez, Eloy, Bartrés-Faz, David, Vidal-Piñeiro, Dídac, González-Ortiz, Sofía, Medrano, Santiago, Carmona-Iragui, María, Sánchez-Saudinós, M<ce:sup loc='post">a</ce:sup>Belén, Sala, Isabel, Anton-Aguirre, Sofía, Sampedro, Frederic, Morenas-Rodríguez, Estrella, Clarimón, Jordi, Blesa, Rafael, Lleó, Alberto, and Fortea, Juan

Published
2015
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15. Clinical utility of plasma biomarkers to identify preclinical Alzheimer’s disease in the community

Author

Lage‐Martinez, Carmen, primary, López‐García, Sara, additional, Martínez, María García, additional, Martínez‐Dubarbie, Francisco, additional, Pozueta, Ana, additional, Arroyo, Juan Martin, additional, Pardo, Andrea Corrales, additional, Irure‐Ventura, Juan, additional, Rodríguez, Eloy Rodríguez, additional, and Sanchez‐Juan, Pascual, additional

Published
2022
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17. ”This looks like a movie”: a case report of post-surgical amnesia

Author

Pozueta, Ana, primary, García-Martínez, María, additional, Bravo, María, additional, Lage, Carmen, additional, López-García, Sara, additional, Martínez-Dubarbie, Francisco, additional, Corrales-Pardo, Andrea, additional, Sedano-Tous, María José, additional, Sánchez-Juan, Pascual, additional, and Rodríguez-Rodríguez, Eloy, additional

Published
2022
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18. Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

Author

Jansen, Ris E., van der Lee, Sven J., Gomez-Fonseca, Duber, de Rojas, Itziar, Dalmasso, Maria Carolina, Grenier-Boley, Benjamin, Zettergren, Anna, Mishra, Aniket, Ali, Muhammad, Andrade, Victor, Bellenguez, Celine, Kleineidam, Luca, Kucukali, Fahri, Sung, Yun Ju, Tesi, Niccolo, Vromen, Ellen M., Wightman, Douglas P., Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Amouyel, Philippe, Athanasiu, Lavinia, Bahrami, Shahram, Bailly, Henri, Belbin, Olivia, Bergh, Sverre, Bertram, Lars, Biessels, Geert Jan, Blennow, Kaj, Blesa, Rafael, Boada, Merce, Boland, Anne, Buerger, Katharina, Carracedo, Angel, Cervera-Carles, Laura, Chene, Genevieve, Claassen, Jurgen A. H. R., Debette, Stephanie, Deleuze, Jean-Francois, de Deyn, Peter Paul, Diehl-Schmid, Janine, Djurovic, Srdjan, Dols-Icardo, Oriol, Dufouil, Carole, Duron, Emmanuelle, Duezel, Emrah, Fladby, Tormod, Fortea, Juan, Froelich, Lutz, Garcia-Gonzalez, Pablo, Garcia-Martinez, Maria, Giegling, Ina, Goldhardt, Oliver, Gobom, Johan, Grimmer, Timo, Haapasalo, Annakaisa, Hampel, Harald, Hanon, Olivier, Hausner, Lucrezia, Heilmann-Heimbach, Stefanie, Helisalmi, Seppo, Heneka, Michael T., Hernandez, Isabel, Herukka, Sanna-Kaisa, Holstege, Henne, Jarholm, Jonas, Kern, Silke, Knapskog, Anne-Brita, Koivisto, Anne M., Kornhuber, Johannes, Kuulasmaa, Teemu, Lage, Carmen, Laske, Christoph, Leinonen, Ville, Lewczuk, Piotr, Lleo, Alberto, de Munain, Adolfo Lopez, Lopez-Garcia, Sara, Maier, Wolfgang, Marquie, Marta, Mol, Merel O., Montrreal, Laura, Moreno, Fermin, Moreno-Grau, Sonia, Nicolas, Gael, Nothen, Markus M., Orellana, Adelina, Palhaugen, Lene, Papma, Janne M., Pasquier, Florence, Perneczky, Robert, Peters, Oliver, Pijnenburg, Yolande A. L., Popp, Julius, Posthuma, Danielle, Pozueta, Ana, Priller, Josef, Puerta, Raquel, Quintela, Ines, Ramakers, Inez, Rodriguez-Rodriguez, Eloy, Rujescu, Dan, Saltvedt, Ingvild, Sanchez-Juan, Pascual, Scheltens, Philip, Scherbaum, Norbert, Schmid, Matthias, Schneider, Anja, Selbaek, Geir, Selnes, Per, Shadrin, Alexey, Skoog, Ingmar, Soininen, Hilkka, Tarraga, Lluis, Teipel, Stefan, Tijms, Betty, Tsolaki, Magda, Van Broeckhoven, Christine, Van Dongen, Jasper, van Swieten, John C., Vandenberghe, Rik, Vidal, Jean-Sebastien, Visser, Pieter J., Vogelgsang, Jonathan, Waern, Margda, Wagner, Michael, Wiltfang, Jens, Wittens, Mandy M. J., Zetterberg, Henrik, Zulaica, Miren, van Duijn, Cornelia M., Bjerke, Maria, Engelborghs, Sebastiaan, Jessen, Frank, Teunissen, Charlotte E., Pastor, Pau, Hiltunen, Mikko, Ingelsson, Martin, Andreassen, Ole A., Clarimon, Jordi, Sleegers, Kristel, Ruiz, Agustin, Ramirez, Alfredo, Cruchaga, Carlos, Lambert, Jean-Charles, van der Flier, Wiesje, Jansen, Ris E., van der Lee, Sven J., Gomez-Fonseca, Duber, de Rojas, Itziar, Dalmasso, Maria Carolina, Grenier-Boley, Benjamin, Zettergren, Anna, Mishra, Aniket, Ali, Muhammad, Andrade, Victor, Bellenguez, Celine, Kleineidam, Luca, Kucukali, Fahri, Sung, Yun Ju, Tesi, Niccolo, Vromen, Ellen M., Wightman, Douglas P., Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Amouyel, Philippe, Athanasiu, Lavinia, Bahrami, Shahram, Bailly, Henri, Belbin, Olivia, Bergh, Sverre, Bertram, Lars, Biessels, Geert Jan, Blennow, Kaj, Blesa, Rafael, Boada, Merce, Boland, Anne, Buerger, Katharina, Carracedo, Angel, Cervera-Carles, Laura, Chene, Genevieve, Claassen, Jurgen A. H. R., Debette, Stephanie, Deleuze, Jean-Francois, de Deyn, Peter Paul, Diehl-Schmid, Janine, Djurovic, Srdjan, Dols-Icardo, Oriol, Dufouil, Carole, Duron, Emmanuelle, Duezel, Emrah, Fladby, Tormod, Fortea, Juan, Froelich, Lutz, Garcia-Gonzalez, Pablo, Garcia-Martinez, Maria, Giegling, Ina, Goldhardt, Oliver, Gobom, Johan, Grimmer, Timo, Haapasalo, Annakaisa, Hampel, Harald, Hanon, Olivier, Hausner, Lucrezia, Heilmann-Heimbach, Stefanie, Helisalmi, Seppo, Heneka, Michael T., Hernandez, Isabel, Herukka, Sanna-Kaisa, Holstege, Henne, Jarholm, Jonas, Kern, Silke, Knapskog, Anne-Brita, Koivisto, Anne M., Kornhuber, Johannes, Kuulasmaa, Teemu, Lage, Carmen, Laske, Christoph, Leinonen, Ville, Lewczuk, Piotr, Lleo, Alberto, de Munain, Adolfo Lopez, Lopez-Garcia, Sara, Maier, Wolfgang, Marquie, Marta, Mol, Merel O., Montrreal, Laura, Moreno, Fermin, Moreno-Grau, Sonia, Nicolas, Gael, Nothen, Markus M., Orellana, Adelina, Palhaugen, Lene, Papma, Janne M., Pasquier, Florence, Perneczky, Robert, Peters, Oliver, Pijnenburg, Yolande A. L., Popp, Julius, Posthuma, Danielle, Pozueta, Ana, Priller, Josef, Puerta, Raquel, Quintela, Ines, Ramakers, Inez, Rodriguez-Rodriguez, Eloy, Rujescu, Dan, Saltvedt, Ingvild, Sanchez-Juan, Pascual, Scheltens, Philip, Scherbaum, Norbert, Schmid, Matthias, Schneider, Anja, Selbaek, Geir, Selnes, Per, Shadrin, Alexey, Skoog, Ingmar, Soininen, Hilkka, Tarraga, Lluis, Teipel, Stefan, Tijms, Betty, Tsolaki, Magda, Van Broeckhoven, Christine, Van Dongen, Jasper, van Swieten, John C., Vandenberghe, Rik, Vidal, Jean-Sebastien, Visser, Pieter J., Vogelgsang, Jonathan, Waern, Margda, Wagner, Michael, Wiltfang, Jens, Wittens, Mandy M. J., Zetterberg, Henrik, Zulaica, Miren, van Duijn, Cornelia M., Bjerke, Maria, Engelborghs, Sebastiaan, Jessen, Frank, Teunissen, Charlotte E., Pastor, Pau, Hiltunen, Mikko, Ingelsson, Martin, Andreassen, Ole A., Clarimon, Jordi, Sleegers, Kristel, Ruiz, Agustin, Ramirez, Alfredo, Cruchaga, Carlos, Lambert, Jean-Charles, and van der Flier, Wiesje

Abstract

Amyloid-beta 42 (A beta 42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for A beta 42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple A beta 42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.

Published
2022

20. Additional file 1 of The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals

Author

López-de-Eguileta, Alicia, López-García, Sara, Lage, Carmen, Pozueta, Ana, García-Martínez, María, Kazimierczak, Martha, Bravo, María, Irure, Juan, López-Hoyos, Marcos, Muñoz-Cacho, Pedro, Rodríguez-Perez, Noelia, Tordesillas-Gutiérrez, Diana, Goikoetxea, Alexander, Nebot, Claudia, Rodríguez-Rodríguez, Eloy, Casado, Alfonso, and Sánchez-Juan, Pascual

Abstract

Additional file 1. Ophthalmological variables analysis as possible confounders. Potential confounders were evaluated by comparing ophthalmological variables (like IOP, pachymetry, AL and refractive error) in individuals with positive versus negative AD biomarkers. These variables did not show significant associations with CSF AD biomarkers.

Published
2022
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22. Environmental Exposure to Manganese and Motor Function in Adults

Author

Ruiz Azcona, Laura, primary, Markiv, Bohdana, additional, Expósito, Andrea, additional, Fernández Olmo, Ignacio, additional, González Aramburu, Isabel, additional, Pozueta, Ana, additional, Sierra Peña, María, additional, García Martínez, María, additional, and Santibáñez, Miguel, additional

Published
2021
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23. Sleep Time Estimated by an Actigraphy Watch Correlates With CSF Tau in Cognitively Unimpaired Elders: The Modulatory Role of APOE

Author

López-García, Sara, primary, Lage, Carmen, additional, Pozueta, Ana, additional, García-Martínez, María, additional, Kazimierczak, Martha, additional, Fernández-Rodríguez, Andrea, additional, Bravo, María, additional, Reyes-González, Luis, additional, Irure, Juan, additional, López-Hoyos, Marcos, additional, Rodríguez-Rodríguez, Eloy, additional, and Sánchez-Juan, Pascual, additional

Published
2021
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24. Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia

Author

Lage, Carmen, López-García, Sara, Bejanin, Alexandre, Kazimierczak, Martha, Aracil-Bolaños, Ignacio, Calvo-Córdoba, Alberto, Pozueta, Ana, García-Martínez, María, Fernández-Rodríguez, Andrea, Bravo-González, María, Jiménez-Bonilla, Julio, Banzo, Ignacio, Irure-Ventura, Juan, Pegueroles, Jordi, Illán-Gala, Ignacio, Fortea, Juan, Rodríguez-Rodríguez, Eloy, Lleó, Alberto, García-Cena, Cecilia E., Sánchez-Juan, Pascual, Universitat Autònoma de Barcelona, Lage, Carmen, López-García, Sara, Bejanin, Alexandre, Kazimierczak, Martha, Aracil-Bolaños, Ignacio, Calvo-Córdoba, Alberto, Pozueta, Ana, García-Martínez, María, Fernández-Rodríguez, Andrea, Bravo-González, María, Jiménez-Bonilla, Julio, Banzo, Ignacio, Irure-Ventura, Juan, Pegueroles, Jordi, Illán-Gala, Ignacio, Fortea, Juan, Rodríguez-Rodríguez, Eloy, Lleó, Alberto, García-Cena, Cecilia E., Sánchez-Juan, Pascual, and Universitat Autònoma de Barcelona

Abstract

Oculomotor behavior can provide insight into the integrity of widespread cortical networks, which may contribute to the differential diagnosis between Alzheimer's disease and frontotemporal dementia. Three groups of patients with Alzheimer's disease, behavioral variant of frontotemporal dementia (bvFTD) and semantic variant of primary progressive aphasia (svPPA) and a sample of cognitively unimpaired elders underwent an eye-tracking evaluation. All participants in the discovery sample, including controls, had a biomarker-supported diagnosis. Oculomotor correlates of neuropsychology and brain metabolism evaluated with 18F-FDG PET were explored. Machine-learning classification algorithms were trained for the differentiation between Alzheimer's disease, bvFTD and controls. A total of 93 subjects (33 Alzheimer's disease, 24 bvFTD, seven svPPA, and 29 controls) were included in the study. Alzheimer's disease was the most impaired group in all tests and displayed specific abnormalities in some visually-guided saccade parameters, as pursuit error and horizontal prosaccade latency, which are theoretically closely linked to posterior brain regions. BvFTD patients showed deficits especially in the most cognitively demanding tasks, the antisaccade and memory saccade tests, which require a fine control from frontal lobe regions. SvPPA patients performed similarly to controls in most parameters except for a lower number of correct memory saccades. Pursuit error was significantly correlated with cognitive measures of constructional praxis and executive function and metabolism in right posterior middle temporal gyrus. The classification algorithms yielded an area under the curve of 97.5% for the differentiation of Alzheimer's disease vs. controls, 96.7% for bvFTD vs. controls, and 92.5% for Alzheimer's disease vs. bvFTD. In conclusion, patients with Alzheimer's disease, bvFTD and svPPA exhibit differentiating oculomotor patterns which reflect the characteristic neuroanatomical dis

Published
2021

25. Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia

Author

Lage, Carmen, primary, López-García, Sara, additional, Bejanin, Alexandre, additional, Kazimierczak, Martha, additional, Aracil-Bolaños, Ignacio, additional, Calvo-Córdoba, Alberto, additional, Pozueta, Ana, additional, García-Martínez, María, additional, Fernández-Rodríguez, Andrea, additional, Bravo-González, María, additional, Jiménez-Bonilla, Julio, additional, Banzo, Ignacio, additional, Irure-Ventura, Juan, additional, Pegueroles, Jordi, additional, Illán-Gala, Ignacio, additional, Fortea, Juan, additional, Rodríguez-Rodríguez, Eloy, additional, Lleó-Bisa, Alberto, additional, García-Cena, Cecilia E., additional, and Sánchez-Juan, Pascual, additional

Published
2021
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26. Major Surgery Affects Memory in Individuals with Cerebral Amyloid-β Pathology

Author

Lage, Carmen, primary, González-Suárez, Andrea, additional, Alcalde-Hierro, María Puerto, additional, Sampedro-González, María Isabel, additional, Villanueva-Eguaras, María Ángeles, additional, Sánchez-Crespo, Manuel Rubén, additional, Widmann, Catherine, additional, Brosseron, Frederic, additional, Pozueta, Ana, additional, López-García, Sara, additional, García-Martínez, María, additional, Kazimierczak, Martha, additional, Bravo-González, María, additional, Fernández-Rodríguez, Andrea, additional, Drake-Pérez, Marta, additional, Irure-Ventura, Juan, additional, López-Hoyos, Marcos, additional, Rodríguez-Rodríguez, Eloy, additional, Heneka, Michael T., additional, and Sánchez-Juan, Pascual, additional

Published
2021
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27. Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study)

Author

Cieuta-Walti, Cécile, Cuenca-Royo, Aida, Langohr, Klaus, Rakic, Claire, López-Vílchez, MaÁngeles, Lirio, Julián, González-Lamuño Leguina, Domingo, González, Teresa Bermejo, García, Jordi García, Roure, Maria Rimblas, Aldea-Perona, Ana, Forcano, Laura, Gomis-Gonzalez, Maria, Cés, Sebastià Videla, Lacaille, Florence, Ravel, Aimé, Mircher, Clotilde, Walti, Hervé, Janel, Nathalie, Dairou, Julien, Lévy, Marilyne, Durand, Sophie, Dierssen, Mara, Sacco, Silvia, Fornell, Rafael de la Torre, Guerrico, Ion Álvarez, Goday, Albert, Llop, Cristina, Mateus, Julián, Matilla, Iris, Esther, Menoyo, Hernández-Ligero, Lorena, Pérez, Marta, Pizarro, Neus, Principe, Alessandro, Cortesi, Anna, Gomez, Alba, Paredes, Noelia, Gomez, Cristina, Graell, Montserrat, López, Pilar, Lozano, Rosario, Medrano, Constancio, Andrade-Navarro, Maria Teresa, Daza, Gema, Garcia, Sandra, Gayán, Ma Luisa, Guerra-Colorado, Cristina, Luna, Beatriz, Maya, Enriqueta, Millan, Delia, Reina, Macarena, Amigo, María Teresa, Fernández, José Luís, García-Martínez, María, Pérez-Poyato, María del Socorro, Pozueta, Ana, Tato, Emma, Viadero, María Teresa, Akkaya, Magnolia, Falquero, Ségolène, Gambarini, Alicia, Akkaya, Magnolia, Falquero, Ségolène, and Gambarini, Alicia

Abstract

Although some caregivers are using epigallocatechin gallate (EGCG) off label in hopes of improving cognition in young adults with Down syndrome (DS), nothing is known about its safety, tolerability, and efficacy in the DS pediatric population. We aimed to evaluate safety and tolerability of a dietary supplement containing EGCG and if EGCG improves cognitive and functional performance.

Published
2022
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28. Evaluation of choroidal thickness in prodromal Alzheimer’s disease defined by amyloid PET

Author

López-de-Eguileta, Alicia, primary, Lage, Carmen, additional, López-García, Sara, additional, Pozueta, Ana, additional, García-Martínez, María, additional, Kazimierczak, Martha, additional, Bravo, María, additional, de Arcocha-Torres, María, additional, Banzo, Ignacio, additional, Jimenez-Bonilla, Julio, additional, Cerveró, Andrea, additional, Goikoetxea, Alexander, additional, Rodríguez-Rodríguez, Eloy, additional, Sánchez-Juan, Pascual, additional, and Casado, Alfonso, additional

Published
2020
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30. Cognitive and Behavioral Profiles of Left and Right Semantic Dementia: Differential Diagnosis with Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease

Author

Pozueta, Ana, primary, Lage, Carmen, additional, García-Martínez, María, additional, Kazimierczak, Martha, additional, Bravo, María, additional, López-García, Sara, additional, Riancho, Javier, additional, González-Suarez, Andrea, additional, Vázquez-Higuera, José Luis, additional, de Arcocha-Torres, María, additional, Banzo, Ignacio, additional, Jiménez-Bonilla, Julio, additional, Berciano, José, additional, Rodríguez-Rodríguez, Eloy, additional, and Sánchez-Juan, Pascual, additional

Published
2019
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31. A Brief Drawing Task for the Differential Diagnosis of Semantic Dementia

Author

Pozueta, Ana, primary, Lage, Carmen, additional, Martínez, María García, additional, Kazimierczak, Martha, additional, Bravo, María, additional, López-García, Sara, additional, Riancho, Javier, additional, González-Suarez, Andrea, additional, Vázquez-Higuera, José Luis, additional, de Arcocha-Torres, María, additional, Banzo, Ignacio, additional, Bonilla, Julio Jimenez, additional, Berciano, José, additional, Rodríguez-Rodríguez, Eloy, additional, and Sánchez-Juan, Pascual, additional

Published
2019
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34. Utility of Amyloid and FDG-PET in Clinical Practice: Differences Between Secondary and Tertiary Care Memory Units

Author

Lage, Carmen, primary, Suarez, Andrea Gonzalez, additional, Pozueta, Ana, additional, Riancho, Javier, additional, Kazimierczak, Martha, additional, Bravo, Maria, additional, Jimenez Bonilla, Julio, additional, de Arcocha Torres, Marıa, additional, Quirce, Remedios, additional, Banzo, Ignacio, additional, Vazquez-Higuera, Jose Luis, additional, Rabinovici, Gil D., additional, Rodriguez-Rodriguez, Eloy, additional, and Sánchez-Juan, Pascual, additional

Published
2018
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35. Heterogeneous Catalytic and Photocatalytic Nitrate Abatement in Drinking Water Using Agpt and Pdsn Supported on Titania Nanocatalysts. Éliminitation du Nitrate dans l'eau Potable par Catalyse Hétèrogène et Photocatalyse au Moyen de Nanocatalyseurs AgPt et

Author

Antolín Pozueta, Ana María, Departament d'Enginyeria Química, Universitat Rovira i Virgili., Contreras Iglesias, Sandra, Medina Cabello, Francisco, Tichit, Didier, and Universitat Rovira i Virgili. Departament d'Enginyeria Química

Subjects
Catàlisi/Fotocatàlisi, Ciències, Drinking water, Denitration, Catalysis/Photocatalysis, Aigüa potable, Desnitració, Desnitración
Abstract

La desnitració d’aigües a gas N2 i H2O usant processos catalítics i foto-catalítics, ha estat investigat en presencia/absència de hidrogen com a gas reductor. Els catalitzadors utilitzats van ser: catalitzadors mono-metàl•lics (Ag/P25, Pt/P25); una barreja física dels catalitzadors mono-metàl•lics (Ag/P25 + Pt/P25); i catalitzadors bimetàl•lics (Ag-Pt(Pt-Ag)/P25 i Pd-Sn/P25). Aquests catalitzadors van ser suportats en Titania P25 amb l’objectiu de demostrar la seva versatilitat en els dos processos (catalític y foto-catalític) per a complir la normativa de la Unió Europea (UE) per a compostos de nitrogen en aigua potable (50 mg/L NO3-, 0.5 mg/L NO2-, 0.3 mg/L NH4+). L’efecte de la quantitat de metall (Ag,Pt), el precursor de Pt (H2PtCl6∙6H2O; K2PtCl6), l’ordre d’impregnació (Ag-Pt,Pt-Ag), i la morfologia (Pd-Sn nano-partícules esfèriques (NPs) i nano-bastons (NRs)) van ser examinades mitjançant diverses tècniques de caracterització (DRX, Fisisorció de N2, MET, DRUV-Vis, XPS, H2-TPR y Quimisorció de H2). Es va aconseguir una bona selectivitat per a N2 (76%) en el procés catalític, utilitzant la mescla de Ag(2)/P25 + Pt(4)/P25(H), però tot i això, es va obtenir també un 13% de NO2-. Els catalitzadors bimetàl•lics van mostrar versatilitat, sent actius en els dos processos. La selectivitat a N2 va ser major amb els NRs (51%) que amb les NPs esfèriques (32%). El Pt(4)-Ag(2)/P25(K) presenta la major selectivitat al N2 (80%). Més estudis són necessaris per a poder reduir els rendiments de NO2- i NH4+., La desnitración de las aguas para la obtención de N2 y H2O ha sido investigada mediante procesos catalíticos y fotocatalíticos, en presencia y ausencia de hidrógeno, el cual se ha usado como agente reductor. Los catalizadores que se utilizaron son: catalizadores monometálicos (Ag/P25, Pt/P25); una mezcla física de los catalizadores monometálicos anteriores (Ag/P25 + Pt/P25); y catalizadores bimetálicos (Ag-Pt (Pt-Ag)/P25 and Pd-Sn/P25). Los catalizadores se soportaron sobre la Titania P25 con el objetivo de probar su posible efectividad en los dos procesos (catalítico y fotocatalítico), para cumplir con la normativa de la Union Europea (UE) sobre compuestos nitrogenados en aguas potables (50 mg/L NO3-, 0.5 mg/L NO2-, 0.3 mg/L NH4+). El efecto de la carga metálica (Ag, Pt), el precursor de Pt (H2PtCl6∙6H2O o K2PtCl6), el orden de impregnación (Ag-Pt, Pt-Ag), y la morfología (Pd-Sn NPs esféricas and nanobastones (NRs)) han sido examinados utilizando varias técnicas de caracterización (DRX, Fisisorción de N2, MET, DRUV-Vis, XPS, H2-TPR y Quimisorción de H2). Se obtuvo una buena selectividad a N2 (76%) en condiciones catalíticas con la mezcla física Ag(2)/P25+Pt(4)/P25(H), pero con un rendimiento a NO2- del ca. 13%. Los catalizadores bimetálicos se mostraron activos en los dos procesos. La selectividad a N2 fue mayor con los NRs (51%) que con las NPs esféricas (32%). El catalizador Pt(4)-Ag(2)/P25(K) presenta la selectividad más alta a N2 (80%). Más estudios necesitan realizarse para disminuir las concentraciones de NO2- and NH4+., Denitration of water towards N2 gas and H2O has been investigated by catalytic and photocatalytic processes in presence/absence of hydrogen as reducing agent. The catalysts used were: monometallic catalysts (Ag/P25, Pt/P25); physical mixture of both monometallics (Ag/P25 + Pt/P25); and bimetallic catalysts (Ag-Pt(Pt-Ag)/P25 and Pd-Sn/P25). These catalysts were supported on Titania P25 with the aim of testing their versatility in both catalytic and photocatalytic processes to accomplish the EU Normative for N-compounds in drinking water (50 mg/L NO3-, 0.5 mg/L NO2-, 0.3 mg/L NH4+). The effect of the metal loading (Ag,Pt), Pt precursor (H2PtCl6∙6H2O; K2PtCl6), impregnation order (Ag-Pt,Pt-Ag), and morphology (Pd-Sn spherical NPs and nanorods (NRs)) were examined through various characterization techniques(XRD, N2- physisorption, TEM, DRUV-Vis, XPS, H2-TPR y H2- Chimisorption). Good N2 selectivity (76%) in the catalytic process was achieved with the Ag(2)/P25+Pt(4)/P25(H) mixture but with ca. 13% NO2- yield. Bimetallic catalysts show versatility being active in both processes. The selectivity to nitrogen for NRs was higher (51%) than that for spherical NPs (32%). Pt(4)-Ag(2)/P25(K) presented the highest selectivity to N2 (80%). Further studies are still needed to decrease NO2- and NH4+ yields.

Published
2016

36. Cortical microstructural changes along the Alzheimer's disease continuum

Author

Montal, Victor, primary, Vilaplana, Eduard, additional, Alcolea, Daniel, additional, Pegueroles, Jordi, additional, Pasternak, Ofer, additional, González‐Ortiz, Sofia, additional, Clarimón, Jordi, additional, Carmona‐Iragui, María, additional, Illán‐Gala, Ignacio, additional, Morenas‐Rodríguez, Estrella, additional, Ribosa‐Nogué, Roser, additional, Sala, Isabel, additional, Sánchez‐Saudinós, María‐Belén, additional, García‐Sebastian, Maite, additional, Villanúa, Jorge, additional, Izagirre, Andrea, additional, Estanga, Ainara, additional, Ecay‐Torres, Mirian, additional, Iriondo, Ane, additional, Clerigue, Montserrat, additional, Tainta, Mikel, additional, Pozueta, Ana, additional, González, Andrea, additional, Martínez‐Heras, Eloy, additional, Llufriu, Sara, additional, Blesa, Rafael, additional, Sanchez‐Juan, Pascual, additional, Martínez‐Lage, Pablo, additional, Lleó, Alberto, additional, and Fortea, Juan, additional

Published
2017
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38. MicroRNA Profile in Patients with Alzheimer’s Disease: Analysis of miR-9-5p and miR-598 in Raw and Exosome Enriched Cerebrospinal Fluid Samples

Author

Riancho, Javier, primary, Vázquez-Higuera, José Luis, additional, Pozueta, Ana, additional, Lage, Carmen, additional, Kazimierczak, Martha, additional, Bravo, María, additional, Calero, Miguel, additional, Gonalezález, Andrea, additional, Rodríguez, Eloy, additional, Lleó, Alberto, additional, and Sánchez-Juan, Pascual, additional

Published
2017
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39. MAPT H1 haplotype is associated with late-onset Alzheimer's disease risk in APOE ε 4 noncarriers: Results from the dementia genetics Spanish consortium

Author

Pastor, Pau, Moreno, Fermín, Antonell, Anna, Elcoroaristizabal, Xabier, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, Belbin, Olivia, Alcolea, Daniel, Carmona-Iragui, María, Sánchez-Saudinós, M Belén, Sala, Isabel, Anton-Aguirre, Sofía, Coto, Eliecer, Morenas, Estrella, Ribosa, Roser, Colom-Cadena, Martí, Cervera, Laura, Muñoz, Laia, Dols-Icardo, Oriol, Clarimón, Jordi, Ortega-Cubero, Sara, Hernandez, Isabel, Tárraga, Lluís, Boada, Mercè, Kulisevsky, Jaime, Vázquez-Higuera, José Luis, Infante, Jon, Rábano, Alberto, Fernández-Blázquez, Miguel Ángel, Valentí, Meritxell, Indakoetxea, Begoña, Barandiarán, Myriam, Gorostidi, Ana, Frank-García, Ana, Sastre, Isabel, Lorenzo, Elena, Ruiz, Agustín, Pastor, María A, Lennarz, Martina, Maier, Wolfgang, Rámirez, Alfredo, Serrano-Ríos, Manuel, Lee, Suzee E, Sánchez-Juan, Pascual, Consortium, Dementia Genetic Spanish, Combarros, Onofre, Lorenzo-Betancor, Oswaldo, Pastor, Maria A, Hernández, Isabel, Lafuente, Asunción, Rosende-Roca, Maitée, Mauleón, Ana, Vargas, Liliana, Rodríguez, Octavio, Calero, Miguel, Abdelnour, Carla, Alegret, Montserrat, Espinosa, Ana, Ortega, Gemma, Sanabria, Ángela, Ibarria, Marta, Diego, Susana, Canyabate, Pilar, Moreno, Mariola, Buendía, Mar, López de Munain, Adolfo, Pancho, Ana, Palacio, María Eugenia, Ruiz, Susana, Tantinya, Natalia, Tarragona, Marina, Morera, América, Guitart, Marina, Sotolongo Grau, Oscar, Martín, Elvira, Fernández, Victòria, Bullido, Maria J, Sánchez-Valle, Raquel, Molinuevo, José Luis, Lladó, Albert, Rami, Lorena, Alvarez, Victoria, de Pancorbo, Marian M, Pozueta, Ana, González Suarez, Andrea, Carro, Eva, Rodriguez-Rodriguez, Eloy, Mateo, Ignacio, Berciano, José, Bullido, María J, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Universidad Pública de Navarra, Universidad del País Vasco, Universidad Autónoma de Madrid, Fundació ACE. Institut Català de Neurociències Aplicades, University of Bonn, University of California, Universitat de Barcelona, Universitat Autònoma de Barcelona, and Universitat Oberta de Catalunya (UOC)

Subjects
Gerontology, Male, associació genètica, genetic association, Apolipoprotein E4, A152T, enfermedad de Alzheimer, genetics [Alzheimer Disease], frontotemporal dementia, MAPT, Alzheimer, Enfermedad de, genetics [Genetic Predisposition to Disease], genetics [Frontotemporal Dementia], genetics [Apolipoprotein E4], Aged, 80 and over, General Neuroscience, General Medicine, demencia frontotemporal, Middle Aged, Alzheimer's disease, Psychiatry and Mental health, Clinical Psychology, demència frontotemporal, genetics [Polymorphism, Single Nucleotide], Christian ministry, Female, Alzheimer’s disease, Frontotemporal dementia, Late onset, MAPT protein, human, tau Proteins, Polymorphism, Single Nucleotide, asociación genética, Alzheimer Disease, malaltia d'Alzheimer, mental disorders, medicine, Dementia, Humans, Genetic Predisposition to Disease, ddc:610, Genetic association, Aged, business.industry, Haplotype, medicine.disease, nervous system diseases, H1H2, genetics [tau Proteins], Alzheimer, Malaltia d', Logistic Models, Haplotypes, Spain, Disease risk, Geriatrics and Gerontology, business
Abstract

The MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 Parkinson's disease (PD), 84 progressive supranuclear palsy (PSP), and 5,950 healthy controls). Additionally, we included 101 individuals from 21 families with genetic FTD. MAPT p.A152T was borderline significantly associated with FTD [odds ratio (OR)=2.03; p=0.063], but not with AD. MAPT H1 haplotype was associated with AD risk (OR=1.12; p=0.0005). Stratification analysis showed that this association was mainly driven by APOE ε4 noncarriers (OR=1.14; p=0.0025). MAPT H1 was also associated with risk for PD (OR=1.30; p=0.0003) and PSP (OR=3.18; p=8.59 × 10-8) but not FTD. Our results suggest that the MAPT H1 haplotype increases the risk of PD, PSP, and non-APOE ε4 AD., Spanish Ministry of Science and Innovation SAF 2006-10126 (2006–2009) and SAF2010-22329-C02-01 (2011–2013) to P.P and by the UTE project FIMA to P.P. Grants from the Ministry of Science (SAF2010-15558) and CIBERNED. Agust´ın Ruiz is supported by grant PI13/02434 (Acción Estratégica en Salud. Instituto de Salud Carlos III. Ministerio de Economía y Competitividad, Spain). Grant: Consolider (CSD2010-00045).

Published
2015
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42. Size and aspect ratio control of Pd2Sn nanorods and their water denitration properties

Author

Catàlisi heterogènia, Departament d'Enginyeria Química, Universitat Rovira i Virgili, ANTOLÍN POZUETA, ANA MARIA, ZhiShan Luo, Maria Ibáñez, Aziz Genc, Alexey Shavel, CONTRERAS IGLESIAS, SANDRA, MEDINA CABELLO, FRANCISCO, Jordi Arbiol, Andreu Cabot, Catàlisi heterogènia, Departament d'Enginyeria Química, Universitat Rovira i Virgili, ANTOLÍN POZUETA, ANA MARIA, ZhiShan Luo, Maria Ibáñez, Aziz Genc, Alexey Shavel, CONTRERAS IGLESIAS, SANDRA, MEDINA CABELLO, FRANCISCO, Jordi Arbiol, and Andreu Cabot

Abstract

Monodisperse Pd2Sn nanorods with tuned size and aspect ratio were prepared by co-reduction of metal salts in the presence of trioctylphosphine, amine, and chloride ions. Asymmetric Pd2Sn nanostructures were achieved by the selective desorption of a surfactant mediated by chlorine ions. A preliminary evaluation of the geometry influence on catalytic properties evidenced Pd2Sn nanorods to have improved catalytic performance. In view of these results, Pd2Sn nanorods were also evaluated for water denitration. © 2015 American Chemical Society.

Published
2015

44. Genetic variation in the tau kinases pathway may contribute to the risk of Alzheimer´s disease

Author

Vázquez Higuera, José Luis, Mateo Fernández, José Ignacio, Sánchez-Juan, Pascual, Rodríguez Rodríguez, Eloy Manuel, Pozueta, Ana, Calero Lara, Miguel, Dobato Ayuso, José Luis, Frank García, Ana, Valdivieso Amate, Fernando, Berciano, José Ángel, Bullido, María Jesús, Combarros Pascual, Onofre, and Universidad de Cantabria

Subjects
Kinases, Alzheimer's disease, Tau, Phosphorylation, Polymorphism
Abstract

Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in Alzheimer´s disease (AD) brain is the result of upregulation of tau kinases. In a group of 729 Spanish late-onset AD patients and 670 healthy controls, we examined variations into a set of 20 candidate genes of kinases involved in tau phosphorylation at AD-related sites (PRKACB; CAMK2A; MARK1, 2, 3 and 4; CSNK1D; CDC2; RPS6KB1 and 2; p38α and β; IB1; JNK1, 2 and 3; MEK1 and 2; ERK1 and 2), to address hypotheses of genetic variation that might influence AD risk. There was an increased frequency of RPS6KB2 (intron 2, rs917570) minor allele in patients (50%) versus controls (39%) (OR = 1.52; 95% CI 1.30-1.77; p = 1.24×10−5 Bonferroni corrected), and the CDC2 AGC haplotype derived from SNPs in introns 3 (rs2448347), 5 (rs2456772), and 7 (rs1871447) showed a protective effect against AD in APOE ε4 allele noncarriers (permutation p = 1.0×10-4) with a frequency of 9% in cases and 15% in controls. Common genetic variation in the tau kinases pathway does underlie individual differences in susceptibility to AD.

Published
2011

45. Caspase-1 genetic variation is not associated with Alzheimer's disease risk

Author

Vázquez-Higuera, José Luis, Rodríguez-Rodríguez, Eloy, Sánchez-Juan, Pascual, Mateo, Ignacio, Pozueta, Ana, Martínez-García, Ana, Frank, Ana, Valdivieso Amate, Fernando, Berciano, José, Bullido, María Jesús, Combarros, Onofre, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), and Universidad de Cantabria

Subjects
Male, lcsh:Internal medicine, lcsh:QH426-470, Genotype, Apolipoprotein E4, Interleukin-1beta, Single-nucleotide polymorphism, Disease, Biology, Polymorphism, Single Nucleotide, Sex Factors, Alzheimer Disease, Risk Factors, Genetic variation, medicine, Genetics, Humans, Genetics(clinical), Allele, lcsh:RC31-1245, Genotyping, Genetics (clinical), Aged, Aged, 80 and over, Haplotype, Caspase 1, Age Factors, Genetic Variation, Middle Aged, medicine.disease, lcsh:Genetics, Haplotypes, Immunology, Female, Alzheimer's disease, Research Article
Abstract

4 pages, 2 tables., [Background] Interleukin (IL)-1β is a potent proinflammatory cytokine markedly overexpressed in the brains of patients with Alzheimer's disease (AD), and also involved in development of atherosclerosis and coronary artery disease. Caspase-1 (CASP1), formerly called IL-1β converting enzyme (ICE), mediates the cleavage of the inactive precursor of IL-1β into the biologically active form. CASP1 genetic variation (G+7/in6A, rs501192) has been associated with susceptibility to myocardial infarction and cardiovascular death risk. We examined the contribution of this gene to the susceptibility for AD., [Methods] We examined genetic variations of CASP1 by genotyping haplotype tagging SNPs (htSNPs) (rs501192, rs556205 and rs530537) in a group of 628 Spanish AD cases and 722 controls., [Results] There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele., [Conclusion] Our negative findings in the Spanish population argue against the hypothesis that CASP1 genetic variations are causally related to AD risk., This study was supported by grants from FIS (PI080139) and CIBERNED (CB06/07/ 0037).

Published
2010

46. MicroRNA Profile in Patients with Alzheimer's Disease: Analysis of miR-9-5p and miR-598 in Raw and Exosome Enriched Cerebrospinal Fluid Samples.

Author

Rianchoa, Javier, Vázquez-Higueraa, José Luis, Pozuetaa, Ana, Lage, Carmen, Kazimierczak, Martha, Bravo, María, Calero, Miguel, González, Andrea, Rodríguez, Eloy, Lleó, Alberto, Sánchez-Juan, Pascual, Riancho, Javier, Vázquez-Higuera, José Luis, Pozueta, Ana, and Gonalezález, Andrea

Subjects
MICRORNA, ALZHEIMER'S disease, CEREBROSPINAL fluid, NEURODEGENERATION, EXOSOMES, LONGITUDINAL method, NERVE tissue proteins, RNA
Abstract

Background: MicroRNAs have been postulated as potential biomarkers for Alzheimer's disease (AD). Exosomes are nanovesicles which transport microRNAs, proteins, and other cargos. It has been hypothesized that the exosome traffic might be increased in neurodegenerative disorders.Objective: i) To assess the cerebrospinal fluid (CSF) microRNA profile in a group of AD patients and control subjects and to validate a group of microRNAs previously reported by other authors. ii) To compare microRNA levels in whole CSF and in the exosome-enriched fraction in AD patients.Methods: A panel of 760 microRNAs was analyzed in the CSF of 10 AD patients and 10 healthy subjects. Among microRNAs differently expressed, we selected those that had been previously reported by other authors. Candidates were validated in a larger group by individual qPCR assays. MicroRNA expression was also evaluated in exosome-enriched CSF samples of patients with AD and controls.Results: Fifteen microRNAs were differently expressed in AD. MiR-9-5p, miR-134, and miR-598 were selected as candidates for further analysis. MiR-9-5p and miR-598 were detected in 50 and 75% of control CSF samples, respectively, while they were not detected in any AD CSF samples. We observed an opposite pattern when we evaluated the microRNA expression in the exosome-enriched CSF AD samples. No pattern variations were noted among healthy subjects.Conclusion: These data propose miR-9-5p and miR-598 as potential biomarkers for AD. Further studies in plasma and other body fluids will confirm their potential role as easily accessible biomarkers. In addition, our data suggest that exosome trafficking is different between AD and control subjects raising the need to take this phenomenon into consideration in future studies of AD biomarkers. [ABSTRACT FROM AUTHOR]

Published
2017
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47. Screening for progranulin mutations by serum protein dosage in common neurodegenerative disorders

Author

Rodríguez-Rodríguez, Eloy, primary, Vázquez-Higuera, José Luis, additional, Sánchez-Juan, Pascual, additional, González-Aramburu, Isabel, additional, Pozueta, Ana, additional, Mateo, Ignacio, additional, Calero, Miguel, additional, Dobato, José Luis, additional, Infante, Jon, additional, Berciano, José, additional, and Combarros, Onofre, additional

Published
2013
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48. Genetic Variation in the Tau Kinases Pathway May Modify the Risk and Age at Onset of Alzheimer's Disease

Author

Vázquez-Higuera, José Luis, primary, Mateo, Ignacio, additional, Sánchez-Juan, Pascual, additional, Rodríguez-Rodríguez, Eloy, additional, Pozueta, Ana, additional, Calero, Miguel, additional, Dobato, José Luis, additional, Frank-García, Ana, additional, Valdivieso, Fernando, additional, Berciano, José, additional, Bullido, Maria J., additional, and Combarros, Onofre, additional

Published
2011
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49. Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk

Author

Vázquez-Higuera, José L, primary, Mateo, Ignacio, additional, Sánchez-Juan, Pascual, additional, Rodríguez-Rodríguez, Eloy, additional, Pozueta, Ana, additional, Calero, Miguel, additional, Dobato, José L, additional, Frank-García, Ana, additional, Valdivieso, Fernando, additional, Berciano, José, additional, Bullido, Maria J, additional, and Combarros, Onofre, additional

Published
2011
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