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Mastery learning -- the process by which students must demonstrate proficiency with a single topic before moving on -- is well recognized as one of the best ways to learn, yet many teachers struggle or remain unsure about how to implement it into a classroom setting. This study leverages two field experiments to test the efficacy of a program designed to encourage greater mastery learning through technology and proactive continuous teacher support. Focusing on elementary and middle school mathematics, teachers receive weekly coaching in how to use Computer Assisted Learning (CAL) for students to follow a customized roadmap of incremental progress. Results indicate significant intent-to-treat effects on math performance of 0.12-0.22 standard deviations. Further analysis shows that these gains are concentrated among students in classrooms with at least an average of 35 minutes of practice per week. Teachers able to achieve high-dosage practice have a high degree of initial buy-in, a clear implementation strategy for when practice occurs, and a willingness to closely monitor progress and follow-up with struggling students. [The Wilson Sheehan Lab for Economic Opportunities (LEO) at Notre Dame provided additional support for this research.]

Recent research across mathematical problem solving, proof assistant programming and multimodal jailbreaking documents a striking finding: when (multimodal) language model tackle a suite of tasks with multiple attempts per task -- succeeding if any attempt is correct -- then the negative log of the average success rate scales a power law in the number of attempts. In this work, we identify an apparent puzzle: a simple mathematical calculation predicts that on each problem, the failure rate should fall exponentially with the number of attempts. We confirm this prediction empirically, raising a question: from where does aggregate polynomial scaling emerge? We then answer this question by demonstrating per-problem exponential scaling can be made consistent with aggregate polynomial scaling if the distribution of single-attempt success probabilities is heavy tailed such that a small fraction of tasks with extremely low success probabilities collectively warp the aggregate success trend into a power law - even as each problem scales exponentially on its own. We further demonstrate that this distributional perspective explains previously observed deviations from power law scaling, and provides a simple method for forecasting the power law exponent with an order of magnitude lower relative error, or equivalently, ${\sim}2-4$ orders of magnitude less inference compute. Overall, our work contributes to a better understanding of how neural language model performance improves with scaling inference compute and the development of scaling-predictable evaluations of (multimodal) language models.

As bound stellar systems orbit within a galaxy, stars may be tidally stripped to form streams of stars that nearly follow the orbit of their progenitor system. Stellar streams provide one of the most promising avenues for constraining the global mass distribution of the Milky Way and the nature of dark matter (DM). The stream stars' kinematic "track" enables inferring large-scale properties of the DM distribution, while density variations and anomalies provide information about local DM clumps (e.g., from DM subhalos). Using precise astrometric data from the Gaia Mission, which enables clean selections of Milky Way stream stars, we now know of a few streams with perturbations and density anomalies. A full accounting of the density tracks and substructures within all >100 Milky Way stellar streams will therefore enable powerful new constraints on DM. However, methods for discovering and characterizing membership of streams are heterogeneous and often highly customized to individual streams. Here we present a new, flexible framework for modeling stellar stream density and membership. Our framework allows us to include off-track or non-Gaussian components to the stream density, meaning we can capture anomalous features (such as the GD-1 steam's spur). We test our model on GD-1, where we characterize previously-known features and provide the largest catalog of probable member stars to date (1689 stars). Our framework (built on JAX and numpyro) provides a path toward uniform analysis of all Milky Way streams, enabling tight constraints on the Galactic mass distribution and its dark matter., Comment: Submitted to ApJ. Comments welcome. Model framework repository at https://github.com/stellarstreams/stream-membership and GD-1-specific application repository at https://github.com/ktavangar/gd1-dr3. Membership probability table will become public upon acceptance. Please contact the authors if you would like access to the membership probability table before then

We present an analysis of millimeter CO observations to search and quantify signatures of molecular gas outflows. We exploit the large sample of $0.5 < z < 2.6$ galaxies observed as part of the PHIBSS1/2 surveys with the IRAM Plateau de Bure interferometer, focusing on the 154 typical massive star-forming galaxies with CO detections (mainly CO(3-2), but including also CO(2-1) and CO(6-5)) at signal-to-noise (SNR) > 1.5 and available properties (stellar mass, star formation rate, size) from ancillary data. None of the individual spectra exhibit a compelling signature of CO outflow emission even at high SNR > 7. To search for fainter outflow signatures, we carry out an analysis of stacked spectra, including the full sample, as well as subsets, split in terms of stellar mass, redshift, inclination, offset in star formation rate (SFR) from the main sequence, and AGN activity. None of the physically motivated subsamples show any outflow signature. We report a tentative detection in a subset statistically designed to maximize outflow signatures. We derive upper limits on molecular gas outflow rate and mass loading factors $\eta$ based on our results and find $\eta \leq$ 2.2-35.4, depending on the subsample. Much deeper CO data and observations of alternative tracers are needed to decisively constrain the importance of cold molecular gas component of outflows relative to other gas phases., Comment: 19 pages, 8 figures. Submitted to ApJ

Cancers are characterized by remarkable heterogeneity and diverse prognosis. Accurate cancer classification is essential for patient stratification and clinical decision-making. Although digital pathology has been advancing cancer diagnosis and prognosis, the paradigm in cancer pathology has shifted from purely relying on histology features to incorporating molecular markers. There is an urgent need for digital pathology methods to meet the needs of the new paradigm. We introduce a novel digital pathology approach to jointly predict molecular markers and histology features and model their interactions for cancer classification. Firstly, to mitigate the challenge of cross-magnification information propagation, we propose a multi-scale disentangling module, enabling the extraction of multi-scale features from high-magnification (cellular-level) to low-magnification (tissue-level) whole slide images. Further, based on the multi-scale features, we propose an attention-based hierarchical multi-task multi-instance learning framework to simultaneously predict histology and molecular markers. Moreover, we propose a co-occurrence probability-based label correlation graph network to model the co-occurrence of molecular markers. Lastly, we design a cross-modal interaction module with the dynamic confidence constrain loss and a cross-modal gradient modulation strategy, to model the interactions of histology and molecular markers. Our experiments demonstrate that our method outperforms other state-of-the-art methods in classifying glioma, histology features and molecular markers. Our method promises to promote precise oncology with the potential to advance biomedical research and clinical applications. The code is available at https://github.com/LHY1007/M3C2, Comment: accepted by Medical Image Analysis

JWST observations have uncovered a new population of red, compact objects at high redshifts dubbed 'Little Red Dots' (LRDs), which typically show broad emission lines and are thought to be dusty Active Galactic Nuclei (AGN). Some of their other features, however, challenge the AGN explanation, such as prominent Balmer breaks and extremely faint or even missing metal high-ionization lines, X-ray, or radio emission, including in deep stacks. Time variability is a unique test of AGN activity. Here, we exploit the $z=7.045$ multiply-imaged LRD A2744-QSO1, which offers a unique test of variability due to lensing-induced time delays between the three images spanning 22 yr (2.7 yr in the rest-frame), to investigate its photometric and spectroscopic variability. We find the equivalent widths (EWs) of the broad H$\alpha$ and H$\beta$ lines, which are independent of magnification and other systematics, to exhibit significant variations, up to $18\pm3$ % for H$\alpha$ and up to $22\pm8$ % in H$\beta$, on a timescale of 875 d (2.4 yr) in the rest-frame. This suggests that A2744-QSO1 is indeed an AGN. We find no significant photometric variability beyond the limiting systematic uncertainties, so it currently cannot be determined whether the EW variations are due to line-flux or continuum variability. These results are consistent with a typical damped random walk (DRW) variability model for an AGN like A2744-QSO1 ($M_{\mathrm{BH}}=4\times10^7 \mathrm{M}_{\odot}$) given the sparse sampling of the light-curve with the available data. Our results therefore support the AGN interpretation of this LRD, and highlight the need for further photometric and spectroscopic monitoring in order to build a detailed and reliable light-curve., Comment: Submitted to A&A. v2 updated to match the submitted version

We present a modular DNA origami design approach to address the challenges of assembling geometrically complex nanoscale structures, including those with nonuniform Gaussian curvature. This approach features a core structure that completely conserves the scaffold routing across different designs and preserves more than 70% of the DNA staples between designs, dramatically reducing both cost and effort, while enabling precise and independent programming of subunit interactions and binding angles through adjustable overhang lengths and sequences. Using cryogenic electron microscopy, gel electrophoresis, and coarse-grained molecular dynamics simulations, we validate a set of robust design rules. We demonstrate the method's utility by assembling a variety of self-limiting structures, including anisotropic shells with controlled inter-subunit interactions and curvature, and a toroid with globally varying curvature. Our strategy is both cost-effective and versatile, providing a promising and efficient solution for the synthetic fabrication of complex nanostructures., Comment: Main text 9 pages, 4 figures, SI 33 pages, 25 figures and 3 tables

Compound identification and structure annotation from mass spectra is a well-established task widely applied in drug detection, criminal forensics, small molecule biomarker discovery and chemical engineering. We propose SpecTUS: Spectral Translator for Unknown Structures, a deep neural model that addresses the task of structural annotation of small molecules from low-resolution gas chromatography electron ionization mass spectra (GC-EI-MS). Our model analyzes the spectra in \textit{de novo} manner -- a direct translation from the spectra into 2D-structural representation. Our approach is particularly useful for analyzing compounds unavailable in spectral libraries. In a rigorous evaluation of our model on the novel structure annotation task across different libraries, we outperformed standard database search techniques by a wide margin. On a held-out testing set, including \numprint{28267} spectra from the NIST database, we show that our model's single suggestion perfectly reconstructs 43\% of the subset's compounds. This single suggestion is strictly better than the candidate of the database hybrid search (common method among practitioners) in 76\% of cases. In a~still affordable scenario of~10 suggestions, perfect reconstruction is achieved in 65\%, and 84\% are better than the hybrid search.

Dynamic microsimulation has long been recognized as a powerful tool for policy analysis, but in fact most major health policy simulations lack path dependency, a critical feature for evaluating policies that depend on accumulated outcomes such as retirement savings, wealth, or debt. We propose LHIEM (the Longitudinal Health, Income and Employment Model), a path-dependent discrete-time microsimulation that predicts annual health care expenditures, family income, and health status for the U.S. population over a multi-year period. LHIEM advances the population from year to year as a Markov chain with modules capturing the particular dynamics of each predictive attribute. LHIEM was designed to assess a health care financing proposal that would allow individuals to borrow from the U.S. government to cover health care costs, requiring careful tracking of medical expenditures and medical debt over time. However, LHIEM is flexible enough to be used for a range of modeling needs related to predicting health care spending and income over time. In this paper, we present the details of the model and all dynamic modules, and include a case study to demonstrate how LHIEM can be used to evaluate proposed policy changes., Comment: To appear in Journal of Artificial Societies and Social Simulation, 2025

The large volume of spectroscopic data available now and from near-future surveys will enable high-dimensional measurements of stellar parameters and properties. Current methods for determining stellar labels from spectra use physics-driven models, which are computationally expensive and have limitations in their accuracy due to simplifications. While machine learning methods provide efficient paths toward emulating physics-based pipelines, they often do not properly account for uncertainties and have complex model structure, both of which can lead to biases and inaccurate label inference. Here we present $Lux$: a data-driven framework for modeling stellar spectra and labels that addresses prior limitations. $Lux$ is a generative, multi-output, latent variable model framework built on JAX for computational efficiency and flexibility. As a generative model, $Lux$ properly accounts for uncertainties and missing data in the input stellar labels and spectral data and can either be used in probabilistic or discriminative settings. Here, we present several examples of how $Lux$ can successfully emulate methods for precise stellar label determinations for stars ranging in stellar type and signal-to-noise from the $APOGEE$ surveys. We also show how a simple $Lux$ model is successful at performing label transfer between the $APOGEE$ and $GALAH$ surveys. $Lux$ is a powerful new framework for the analysis of large-scale spectroscopic survey data. Its ability to handle uncertainties while maintaining high precision makes it particularly valuable for stellar survey label inference and cross-survey analysis, and the flexible model structure allows for easy extension to other data types., Comment: 30 pages, 19 figures, 1 Table. Thoughts and comments welcome!

The electric dipole moments~(EDM) of fundamental particles inherently violate parity~(P) and time-reversal~(T) symmetries. By virtue of the CPT theorem in quantum field theory, the latter also implies the violation of the combined charge-conjugation and parity~(CP) symmetry. We aim to measure the EDM of the muon using the frozen-spin technique within a compact storage trap. This method exploits the high effective electric field, \$E \approx 165\$ MV/m, experienced in the rest frame of the muon with a momentum of about 23 MeV/c when it passes through a solenoidal magnetic field of \$|\vec{B}|=2.5\$ T. In this paper, we outline the fundamental considerations for a muon EDM search and present a conceptual design for a demonstration experiment to be conducted at secondary muon beamlines of the Paul Scherrer Institute in Switzerland. In Phase~I, with an anticipated data acquisition period of 200 days, the expected sensitivity to a muon EDM is 4E-21 ecm. In a subsequent phase, Phase~II, we propose to improve the sensitivity to 6E-23 ecm using a dedicated instrument installed on a different beamline that produces muons of momentum 125 MeV/c}., Comment: 34 pages, submitted to EPJC

In this article we study the existence of solutions to a fourth-order nonlinear PDE related to crystal surface growth. The key difficulty in the equations comes from the mobility matrix, which depends on the gradient of the solution. When the mobility matrix is the identity matrix there are now many existence results, however when it is allowed to depend on the solution we lose crucial estimates in the time direction. In this work we are able to prove the global existence of weak solutions despite this lack of estimates in the time direction.

We note that Weihrauch problems can be regarded as containers over the category of projective represented spaces and that Weihrauch reductions correspond exactly to container morphisms. We also show that Bauer's extended Weihrauch degrees and the posetal reflection of containers over partition assemblies are equivalent. Using this characterization, we show how a number of operators over Weihrauch degrees, such as the composition product, also arise naturally from the abstract theory of polynomial functors., Comment: 25 pages

Hydrodynamical simulations of protoplanetary disk dynamics are useful tools for understanding the formation of planetary systems, including our own. Approximations are necessary to make these simulations computationally tractable. A common assumption when simulating dust fluids is that of a constant Stokes number, a dimensionless number that characterizes the interaction between a particle and the surrounding gas. Constant Stokes number is not a good approximation in regions of the disk where the gas density changes significantly, such as near a planet-induced gap. In this paper, we relax the assumption of constant Stokes number in the popular FARGO3D code using semi-analytic equations for the drag force on dust particles, which enables an assumption of constant particle size instead. We explore the effect this change has on disk morphology and particle fluxes across the gap for both outward- and inward-drifting particles. The assumption of constant particle size, rather than constant Stokes number, is shown to make a significant difference in some cases, emphasizing the importance of the more accurate treatment., Comment: Accepted version with minor author edits; published in ApJ

Inclusive electron scattering cross sections off a hydrogen target at a beam energy of 10.6 GeV have been measured with data collected from the CLAS12 spectrometer at Jefferson Laboratory. These first absolute cross sections from CLAS12 cover a wide kinematic area in invariant mass W of the final state hadrons from the pion threshold up to 2.5 GeV for each bin in virtual photon four-momentum transfer squared $Q^2$ from 2.55 to 10.4~GeV$^2$ owing to the large scattering angle acceptance of the CLAS12 detector. Comparison of the cross sections with the resonant contributions computed from the CLAS results on the nucleon resonance electroexcitation amplitudes has demonstrated a promising opportunity to extend the information on their $Q^2$ evolution up to 10 GeV$^2$. Together these results from CLAS and CLAS12 offer good prospects for probing the nucleon parton distributions at large fractional parton momenta $x$ for $W$ < 2.5 GeV, while covering the range of distances where the transition from the strongly coupled to the perturbative regimes is expected.

Self-supervised deep learning has accelerated 2D natural image analysis but remains difficult to translate into 3D MRI, where data are scarce and pre-trained 2D backbones cannot capture volumetric context. We present a sequence-invariant self-supervised framework leveraging quantitative MRI (qMRI). By simulating multiple MRI contrasts from a single 3D qMRI scan and enforcing consistent representations across these contrasts, we learn anatomy-centric rather than sequence-specific features. This yields a robust 3D encoder that performs strongly across varied tasks and protocols. Experiments on healthy brain segmentation (IXI), stroke lesion segmentation (ARC), and MRI denoising show significant gains over baseline SSL approaches, especially in low-data settings (up to +8.3% Dice, +4.2 dB PSNR). Our model also generalises effectively to unseen sites, demonstrating potential for more scalable and clinically reliable volumetric analysis. All code and trained models are publicly available.

Globular clusters (GCs) are some of the oldest bound structures in the Universe, holding clues to the earliest epochs of star formation and galaxy assembly. However, accurate age measurements of ancient clusters are challenging due to the age-metallicity degeneracy. Here, we report the discovery of 42 compact stellar systems within the 'Relic', a massive, quiescent galaxy at $z=2.53$. The Relic resides in an over-density behind the Abell 2744 cluster, with a prominent tidal tail extending towards two low-mass companions. Using deep data from the UNCOVER/MegaScience JWST Surveys, we find that clusters formed in age intervals ranging from 8 Myr up to $\sim2$ Gyr, suggesting a rich formation history starting at $z\sim10$. While the cluster-based star formation history is broadly consistent with the high past star formation rates derived from the diffuse host galaxy light, one potential discrepancy is a tentative $\sim2-3\times$ higher rate in the cluster population for the past Gyr. Taken together with the spatial distribution and low inferred metallicities of these young-to-intermediate age clusters, we may be seeing direct evidence for the accretion of star clusters in addition to their early in-situ formation. The cluster masses are high, $\sim10^6-10^7~M_{\odot}$, which may explain why we are able to detect them around this likely post-merger galaxy. Overall, the Relic clusters are consistent with being precursors of the most massive present-day GCs. This unique laboratory enables the first connection between long-lived, high-redshift clusters and local stellar populations, offering insights into the early stages of GC evolution and the broader processes of galaxy assembly., Comment: 19 pages, 7 figures, submitted to Astrophysical Journal on January 9, 2025 (comments welcome!)

We present the results of combined hydrodynamic and particle tracking post-processing modeling to study the transport of small dust in a protoplanetary disk containing an embedded embryo in 3D. We use a suite of FARGO3D hydrodynamic simulations of disks containing a planetary embryo varying in mass up to 300 $M_\oplus$ on a fixed orbit in both high and low viscosity disks. We then simulate solid particles through the disk as a post-processing step using a Monte Carlo integration, allowing us to track the trajectories of individual particles as they travel throughout the disk. We find that gas advection onto the planet can carry small, well-coupled solids across the gap opened in the disk by the embedded planet for planetary masses above the pebble isolation mass. This mixing between the inner and outer disk can occur in both directions, with solids in the inner disk mixing to the outer disk as well. Additionally, in low viscosity disks, multiple pile-ups in the outer disk may preserve isotopic heterogeneities, possibly providing an outermost tertiary isotopic reservoir. Throughout Jupiter's growth, the extent of mixing between isotopic reservoirs varied depending on dust size, gas turbulence, and the Jovian embryo mass., Comment: 21 pages, 13 figures, accepted for publication in ApJ

We introduce a two-fluid mobility model incorporating fundamental aspects of electron-hole (e-h) scattering such as momentum conservation for simulating laser-driven semiconductor switches (LDSSs). Compared to previous works that use Matthiessen's rule, the two-fluid mobility model predicts distinct AC responses of e-h plasmas in semiconductors. Based on the two-fluid mobility model, we develop a theory with very few adjustable parameters for simulating the switching performance of LDSSs based on high-purity indirect-gap semiconductors such as silicon (Si). As a prototypical application, we successfully reproduce experimentally measured reflectance at around 320 GHz in a laser-driven Si switch. By injecting e-h plasmas with densities up to $10^{20}\,\rm cm^{-3}$, we reveal the importance of carrier-screening effects in e-h scattering and Auger recombination for carrier densities above the critical carrier density for exciton-plasma Mott transition. Our results also suggest a way to characterize the intrinsic momentum-relaxation mechanism, e-h scattering, and the intrinsic e-h recombination mechanism in indirect-gap semiconductors, Auger recombination. We reassess the ambipolar Auger coefficient of high-purity Si with high injection levels of e-h plasmas up to $10^{20}\,\rm cm^{-3}$ and find a minimal value of $1.8\times10^{-41}\,{\rm cm^6/ns}$. The value is more than one order of magnitude smaller than the ambipolar Auger coefficient widely used for simulating LDSSs, $3.8\times10^{-40}\,{\rm cm^6/ns}$, which was deduced from minority-carrier lifetime in highly doped silicon more than four decades ago.

The James Webb Space Telescope (JWST) is unveiling the rest-frame near-IR structure of galaxies. We measure the evolution with redshift of the rest-frame optical and near-IR S\'ersic index ($n$), and examine the dependence on stellar mass and star-formation activity across the redshift range $0.5\leq z\leq2.5$. We infer rest-frame near-IR S\'ersic profiles for $\approx 15.000$ galaxies in publicly available NIRCam imaging mosaics from the COSMOS-Web and PRIMER surveys. We augment these with rest-frame optical S\'ersic indices, previously measured from HST imaging mosaics. The median S\'ersic index evolves slowly or not at all with redshift, except for very high-mass galaxies ($M_\star > 10^{11}~{\text{M}}_\odot$), which show an increase from $n\approx 2.5$ to $n\approx 4$ at $z<1$. High-mass galaxies have higher $n$ than lower-mass galaxies ($M_\star=10^{9.5}~{\text{M}}_\odot$) at all redshifts, with a stronger dependence in the rest-frame near-IR than in the rest-frame optical at $z>1$. This wavelength dependence is caused by star-forming galaxies that have lower optical than near-IR $n$ at z>1 (but not at z<1). Both at optical and near-IR wavelengths, star-forming galaxies have lower $n$ than quiescent galaxies, fortifying the connection between star-formation activity and radial stellar mass distribution. At $z>1$ the median near-IR $n$ varies strongly with star formation activity, but not with stellar mass. The scatter in near-IR $n$ is higher in the green valley (0.25 dex) than on the star-forming sequence and among quiescent galaxies (0.18 dex) -- this trend is not seen in the optical because dust and young stars contribute to the variety in optical light profiles. Our newly measured rest-frame near-IR radial light profiles motivate future comparisons with radial stellar mass profiles of simulated galaxies as a stringent constraint on processes that govern galaxy formation., Comment: Accepted for publication on A&A

DarkSide-20k is a novel liquid argon dark matter detector currently under construction at the Laboratori Nazionali del Gran Sasso (LNGS) of the Istituto Nazionale di Fisica Nucleare (INFN) that will push the sensitivity for Weakly Interacting Massive Particle (WIMP) detection into the neutrino fog. The core of the apparatus is a dual-phase Time Projection Chamber (TPC), filled with \SI{50} {tonnes} of low radioactivity underground argon (UAr) acting as the WIMP target. NUV-HD-Cryo Silicon Photomultipliers (SiPM)s designed by Fondazione Bruno Kessler (FBK) (Povo, Trento, Italy) were selected as the photon sensors covering two $10.5~\text{m}^2$ Optical Planes, one at each end of the TPC, and a total of $5~\text{m}^2$ photosensitive surface for the liquid argon veto detectors. This paper describes the Quality Assurance and Quality Control (QA/QC) plan and procedures accompanying the production of FBK~NUV-HD-Cryo SiPM wafers manufactured by LFoundry s.r.l. (Avezzano, AQ, Italy). SiPM characteristics are measured at 77~K at the wafer level with a custom-designed probe station. As of May~2024, 603 of the 1400 production wafers (43\% of the total) for DarkSide-20k were tested, including wafers from all 57 production Lots. The wafer yield is $93.6\pm2.5$\%, which exceeds the 80\% specification defined in the original DarkSide-20k production plan.

To meet its commitments under the Paris Agreement and reduce its dependency on energy imports, the pace, and scale of renewable energy deployment across Europe must increase dramatically over the next decade. Such a steep change in the net-zero transition will inevitably necessitate trade-offs with other societal priorities. Here we investigate a case study focused on the opposition towards onshore wind and the compromises that may need to be made to deliver its plans for deep electrification. Using an electricity system model, we explore the implications of key social and environmental dimensions shaping the future deployment of onshore wind on the costs and design of electricity systems for Norway in 2030. We find that under restrictions that allow for almost no additional onshore wind, demand can not be met and load has to be shed. Yet, when reducing the restrictions on onshore wind or allowing for in-country transmission expansion, feasible system designs at a small fraction of that cost can be found. To meet the net-zero targets, compromises will need to be made on either wind power deployment, transmission expansion, non-electrification of industry or demand reduction.

To optimize interventions for improving wellness, it is essential to understand habits, which wearable devices can measure with greater precision. Using high temporal resolution biometric data taken from the Oura Gen3 ring, we examine daily and weekly sleep and activity patterns of a cohort of young adults (N=582) in their first semester of college. A high compliance rate is observed for both daily and nightly wear, with slight dips in wear compliance observed shortly after waking up and also in the evening. Most students have a late-night chronotype with a median midpoint of sleep at 5AM, with males and those with mental health impairment having more delayed sleep periods. Social jetlag, or the difference in sleep times between free days and school days, is prevalent in our sample. While sleep periods generally shift earlier on weekdays and later on weekends, sleep duration on both weekdays and weekends is shorter than during prolonged school breaks, suggesting chronic sleep debt when school is in session. Synchronized spikes in activity consistent with class schedules are also observed, suggesting that walking in between classes is a widespread behavior in our sample that substantially contributes to physical activity. Lower active calorie expenditure is associated with weekends and a delayed but longer sleep period the night before, suggesting that for our cohort, active calorie expenditure is affected less by deviations from natural circadian rhythms and more by the timing associated with activities. Our study shows that regular sleep and activity routines may be inferred from consumer wearable devices if high temporal resolution and long data collection periods are available.

Stellar streams from disrupted globular clusters are dynamically cold structures that are sensitive to perturbations from dark matter subhalos, allowing them in principle to trace the dark matter substructure in the Milky Way. We model, within the context of $\Lambda$CDM, the likelihood of dark matter subhalos to produce a significant feature in a GD-1-like stream and analyze the properties of such subhalos. We generate a large number of realizations of the subhalo population within a Milky Way mass host halo, accounting for tidal stripping and dynamical friction, using the semi-analytic code SatGen. The subhalo distributions are combined with a GD-1-like stream model, and the impact of subhalos that pass close to the stream are modeled with Gala. We find that subhalos with masses in the range $5\times 10^6 M_{\odot} - 10^8 M_{\odot}$ at the time of the stream-subhalo encounter, corresponding to masses of about $4 \times 10^7 M_{\odot} - 8 \times 10^8 M_{\odot}$ at the time of infall, are the likeliest to produce gaps in a GD-1-like stream. We find that gaps occur on average $\sim$1.8 times per realization of the host system. These gaps have typical widths of $\sim(7 - 27)$ deg and fractional underdensities of $\sim (10 - 30)\%$, with larger gaps being caused by more-massive subhalos. The stream-subhalo encounters responsible for these have impact parameters $(0.1 - 1.5)$ kpc and relative velocities $\sim(170 - 410)$ km/s. For a larger host-halo mass, the number of subhalos increases, as do their typical velocities, inducing a corresponding increase in the number of significant stream-subhalo encounters., Comment: 20 pages, 10 figures

Functional gradients have recently experienced an explosion in activity due to advances in manufacturing, where compositions can now be spatially varied on-the-fly during fabrication. In addition, modern computational thermodynamics has reached sufficient maturity -- with respect to property databases and the availability of commercial software -- that gradients can be designed with specific sets of properties. Despite these successes, there are practical limitations on the calculation speeds of these thermodynamic tools that make it intractable to model every element in an alloy. As a result, most path planning is carried out via surrogate models on simplified systems (e.g., approximating Inconel 718 as Ni$_{59}$Cr$_{23}$Fe$_{18}$ instead of Ni$_{53}$Cr$_{23}$Fe$_{18}$Nb$_{3}$Mo$_{2}$Ti$_{1}$). In this work, we demonstrate that this limitation can be overcome using a combination of on-the-fly sampling and a conjectured corollary of the lever rule for transformations of isothermal paths in arbitrary compositional dimensions. We quantitatively benchmark the effectiveness of this new method and find that it can be as much as 106 times more efficient than surrogate modeling., Comment: 25 pages, 7 figures, 3 supplementary figures, 1 table

We present phi-4, a 14-billion parameter language model developed with a training recipe that is centrally focused on data quality. Unlike most language models, where pre-training is based primarily on organic data sources such as web content or code, phi-4 strategically incorporates synthetic data throughout the training process. While previous models in the Phi family largely distill the capabilities of a teacher model (specifically GPT-4), phi-4 substantially surpasses its teacher model on STEM-focused QA capabilities, giving evidence that our data-generation and post-training techniques go beyond distillation. Despite minimal changes to the phi-3 architecture, phi-4 achieves strong performance relative to its size -- especially on reasoning-focused benchmarks -- due to improved data, training curriculum, and innovations in the post-training scheme.

We study the rest-frame optical and ultraviolet morphology of galaxies in the first billion years of the Universe. Using JWST data from the UNCOVER and MegaScience surveys targeting the lensing cluster Abell 2744 we present multi-band morphological measurements for a sample of 995 galaxies selected using 20-band NIRCam photometry and 35 using NIRSpec Prism spectroscopy over the redshift range of $4

The Breakthrough Listen program is, to date, the most extensive search for technological life beyond Earth. As part of this goal, over the past nine years it has surveyed thousands of nearby stars, close to 100 nearby galaxies, and a variety of exotic and solar system objects with telescopes around the world, including the Robert C. Byrd Green Bank Telescope (GBT) in West Virginia. The goal is to find evidence of technosignatures of other civilizations, such as narrowband Doppler drifting radio signals. Despite the GBT's location in a radio-quiet zone, the primary challenge of this search continues to be the high quantities of human-generated radio-frequency interference (RFI), and the ability to pick out genuinely promising candidates from it. Here we present a novel search method aimed at finding these `needle-in-a-haystack' type signals, applied to 9,684 observation cadences of 3,077 stars (each observed with one or more of the L, S, C, and X band receivers) from the GBT archive. We implement a low-complexity statistical process to vet out RFI and highlight signals that, upon visual inspection, appear more promising than those from previous analyses. Our work returns candidate signals found previously using both traditional and machine learning algorithms, as well as many promising ones not previously identified. This analysis represents the largest dataset searched for technosignatures to date, and highlights the efficacy that traditional (non-machine-learning) algorithms continue to have in these types of technosignature searches. We find that less than 1% of stars host transmitters brighter than 0.3 Arecibo radar equivalents broadcasting in our direction over the frequency band covered., Comment: 24 pages, 17 figures. Submitted to Astronomy & Astrophysics

We present a detailed exploration of the most optically-luminous Little Red Dot ($L_{H\alpha}=10^{44}$erg/s, $L_V=10^{45}$erg/s, F444W=22AB) found to date. Located in the Abell 2744 field, source A744-45924 was observed by NIRSpec/PRISM with ultradeep spectroscopy reaching SNR$\sim$100pix$^{-1}$, high-resolution 3-4 micron NIRCam/Grism spectroscopy, and NIRCam Medium Band imaging. The NIRCam spectra reveal high rest-frame EW $W_{H\alpha,0,broad}>800$\r{A}, broad H$\alpha$ emission (FWHM$\sim$4500 km/s), on top of narrow, complex absorption. NIRSpec data show exceptionally strong rest-frame UV to NIR Fe II emission ($W_{FeII-UV,0}\sim$340\r{A}), N IV]$\lambda\lambda$1483,1486 and N III]$\lambda$1750, and broad NIR O I $\lambda$8446 emission. The spectra unambiguously demonstrate a broad-line region associated with an inferred $M_{BH}\sim10^9M_\odot$ supermassive black hole embedded in dense gas, which might explain a non-detection in ultradeep Chandra X-ray data (>$10\times$ underluminous relative to broad $L_{H\alpha}$). Strong UV Nitrogen lines suggest supersolar N/O ratios due to rapid star formation or intense radiation near the AGN. The continuum shows a clear Balmer break at rest-frame 3650\r{A}, which cannot be accounted for by an AGN power-law alone. A stellar population model produces an excellent fit with a reddened Balmer break and implying a massive ($M_*\sim8\times10^{10}M_\odot$), old $\sim$500 Myr, compact stellar core, among the densest stellar systems known ($\rho\sim3\times10^6M_\odot$/pc$^2$ for $R_{e,opt}=70\pm10$ pc), and AGN emission with extreme intrinsic EW $W_{H\alpha,0}\gg$1000\r{A}. However, although high $M_*$ and $M_{BH}$ are supported by evidence of an overdensity containing 40 galaxies at $z=4.41-4.51$, deep high-resolution spectroscopy is required to confirm stellar absorption and rule out that dense gas around the AGN causes the Balmer break instead., Comment: 28 pages,10 figures, submitted to ApJ

We introduce Best-of-N (BoN) Jailbreaking, a simple black-box algorithm that jailbreaks frontier AI systems across modalities. BoN Jailbreaking works by repeatedly sampling variations of a prompt with a combination of augmentations - such as random shuffling or capitalization for textual prompts - until a harmful response is elicited. We find that BoN Jailbreaking achieves high attack success rates (ASRs) on closed-source language models, such as 89% on GPT-4o and 78% on Claude 3.5 Sonnet when sampling 10,000 augmented prompts. Further, it is similarly effective at circumventing state-of-the-art open-source defenses like circuit breakers. BoN also seamlessly extends to other modalities: it jailbreaks vision language models (VLMs) such as GPT-4o and audio language models (ALMs) like Gemini 1.5 Pro, using modality-specific augmentations. BoN reliably improves when we sample more augmented prompts. Across all modalities, ASR, as a function of the number of samples (N), empirically follows power-law-like behavior for many orders of magnitude. BoN Jailbreaking can also be composed with other black-box algorithms for even more effective attacks - combining BoN with an optimized prefix attack achieves up to a 35% increase in ASR. Overall, our work indicates that, despite their capability, language models are sensitive to seemingly innocuous changes to inputs, which attackers can exploit across modalities.

Segmenting stroke lesions in Magnetic Resonance Imaging (MRI) is challenging due to diverse clinical imaging domains, with existing models struggling to generalise across different MRI acquisition parameters and sequences. In this work, we propose two novel physics-constrained approaches using synthetic quantitative MRI (qMRI) images to enhance the robustness and generalisability of segmentation models. We trained a qMRI estimation model to predict qMRI maps from MPRAGE images, which were used to simulate diverse MRI sequences for segmentation training. A second approach built upon prior work in synthetic data for stroke lesion segmentation, generating qMRI maps from a dataset of tissue labels. The proposed approaches improved over the baseline nnUNet on a variety of out-of-distribution datasets, with the second approach outperforming the prior synthetic data method.

In the last decade, we have been able to probe further down the galaxy luminosity function than ever before and expand into the regime of ultra-faint dwarfs (UFDs), which are some of the best probes we have of small-scale cosmology and galaxy formation. Digital sky surveys have enabled the discovery and study of these incredibly low-mass, highly dark-matter dominated systems around the Local Group, but it is critical that we expand the satellite census further out to understand if Milky Way and M31 satellites are representative of dwarf populations in the local Universe. Using data from HST/ACS, we present updated characterization of four satellite systems in the M81 group. These systems - D1005+68, D1006+69, DWJ0954+6821, and D1009+68 - were previously discovered using ground-based Subaru HSC data as overdensities in M81's halo and are now confirmed with HST/ACS by this work. These are all faint (M_V >= -7.9) and consistent with old (~13 Gyr), metal-poor ([M/H] < -1.5) populations. Each system possesses relatively unusual features - including one of the most concentrated satellite galaxies with a Sersic index of n ~ 5, one of the most elliptical galaxies outside the Local Group with an e ~ 0.6, and one of the most compact galaxies for its magnitude. Two of the satellites have very low surface brightness, lower than most known galaxies in this absolute magnitude range. This work previews the scientific promise of the upcoming Rubin Observatory and Roman Telescope for illuminating the diversity of UFDs in the Local Volume and beyond., Comment: 24 pages, 12 figures, 1 appendix, accepted to ApJ

Personalized image generation has emerged from the recent advancements in generative models. However, these generated personalized images often suffer from localized artifacts such as incorrect logos, reducing fidelity and fine-grained identity details of the generated results. Furthermore, there is little prior work tackling this problem. To help improve these identity details in the personalized image generation, we introduce a new task: reference-guided artifacts refinement. We present Refine-by-Align, a first-of-its-kind model that employs a diffusion-based framework to address this challenge. Our model consists of two stages: Alignment Stage and Refinement Stage, which share weights of a unified neural network model. Given a generated image, a masked artifact region, and a reference image, the alignment stage identifies and extracts the corresponding regional features in the reference, which are then used by the refinement stage to fix the artifacts. Our model-agnostic pipeline requires no test-time tuning or optimization. It automatically enhances image fidelity and reference identity in the generated image, generalizing well to existing models on various tasks including but not limited to customization, generative compositing, view synthesis, and virtual try-on. Extensive experiments and comparisons demonstrate that our pipeline greatly pushes the boundary of fine details in the image synthesis models.

Observational studies are identifying stars thought to be remnants from the earliest stages of the hierarchical mass assembly of the Milky Way, referred to as the proto-Galaxy. We use red giant stars with kinematics and [$\alpha$/M] and [M/H] estimates from Gaia DR3 data to investigate the relationship between azimuthal velocity and metallicity, aiming to understand the transition from a chaotic proto-Galaxy to a well-ordered, rotating (old) disc-like population. To analyse the structure of the data in [M/H]-v$_\phi$ space for both high- and low-$\alpha$ samples with carefully defined $\alpha$-separation, we develop a model with two Gaussian components in v$_\phi$: one representing a disc-like population and the other a halo-like population. This model is designed to capture the conditional distribution P(v$_\phi$ $\mid$ [M/H]) with a 2-component Gaussian Mixture Model with fixed azimuthal velocities means and standard deviations. To quantify the spin-up of the high-$\alpha$ disc population, we extend this two-component model by allowing the mean velocity and velocity dispersion to vary between the spline knots across the metallicity range used. We also compare our findings with existing literature using traditional Gaussian Mixture Modelling in bins of [M/H] and investigate using orbital circularity instead of azimuthal velocity. Our findings show that the metal-poor high-$\alpha$ disc gradually spins up across [M/H] $\sim$ -1.7 to -1.0, while the low-$\alpha$ sample exhibits a sharp transition at [M/H] $\sim$ -1.0. This latter result is due to the accreted debris dominating the metal-poor end, underscoring the critical role of [$\alpha$/M] selection in studying the (old) disc evolution of the Milky Way. These results indicate that the proto-Galaxy underwent a slow, monotonic spin-up phase rather than a rapid, dramatic spin-up at [M/H] $\sim$ -1.0, as previously inferred., Comment: Submitted to A&A. 19 pages + 11 figures, 6 pages + 5 figures in appendix. Comments are very welcome!

Interactions and reconnections of vortices are fundamental in many areas of physics, including classical and quantum fluids where they are central to understanding phenomena such as turbulence. In three-dimensional (3D) superfluids, quantum vortices are one-dimensional (1D) filaments that can intersect, reconnect, and recoil with irreversible dynamics described by near-universal scaling laws. We explore quantum-vortex reconnections in a four-dimensional (4D) superfluid, where a vortex is a two-dimensional (2D) surface. Using real-time numerical simulations, we find much richer behaviour than in 3D, including stable intersecting vortex surfaces which do not reconnect, and unusual vortex reconnections which occur without significant energy dissipation, suggesting quasi-reversible dynamics. Our work raises many interesting questions about vortex physics in extra-dimensional systems, and may be extended in the future to more realistic experimental settings where the fourth dimension is simulated with techniques such as synthetic dimensions., Comment: 8 pages, 4 figures

Spatially-resolved emission line kinematics are invaluable to investigating fundamental galaxy properties and have become increasingly accessible for galaxies at $z\gtrsim0.5$ through sensitive near-infrared imaging spectroscopy and millimeter interferometry. Kinematic modeling is at the core of the analysis and interpretation of such data sets, which at high-z present challenges due to lower signal-to-noise ratio (S/N) and resolution compared to data of local galaxies. We present and test the 3D fitting functionality of DysmalPy, examining how well it recovers intrinsic disk rotation velocity and velocity dispersion, using a large suite of axisymmetric models, covering a range of galaxy properties and observational parameters typical of $z\sim1$-$3$ star-forming galaxies. We also compare DysmalPy's recovery performance to that of two other commonly used codes, GalPak3D and 3DBarolo, which we use in turn to create additional sets of models to benchmark DysmalPy. Over the ranges of S/N, resolution, mass, and velocity dispersion explored, the rotation velocity is accurately recovered by all tools. The velocity dispersion is recovered well at high S/N, but the impact of methodology differences is more apparent. In particular, template differences for parametric tools and S/N sensitivity for the non-parametric tool can lead to differences up to a factor of 2. Our tests highlight and the importance of deep, high-resolution data and the need for careful consideration of: (1) the choice of priors (parametric approaches), (2) the masking (all approaches) and, more generally, evaluating the suitability of each approach to the specific data at hand. This paper accompanies the public release of DysmalPy., Comment: 38 pages, 21 figures, accepted for publication in ApJ

Among the most puzzling early discoveries of JWST are "Little Red Dots" -- compact red sources that host broad Balmer emission lines and, in many cases, exhibit a "V shaped" change in slope in the rest-optical. The physical properties of Little Red Dots currently have order-of-magnitude uncertainties, because models to explain the continuum of these sources differ immensely. Here, we leverage the complete selection of red sources in the RUBIES program, supplemented with public PRISM spectra, to study the origin of this "V shape". By fitting a broken power law with a flexible inflection point, we find that a large fraction (20/44, nearly all spatially unresolved) of extremely red H$\alpha$ emitters at $2

Powered ankle-foot prostheses can often reduce the energy cost of walking by assisting with push-off. However, focus on providing mechanical work may lead to ignoring or exacerbating common issues with chronic pain, irritation, pressure ulcer development, and eventual osteoarthritis in persons with amputation. This paper presents the design and validation of a novel transtibial prosthesis informed by predictive biomechanical simulations of gait which minimize a combination of user effort and interaction loading from the prosthesis socket. From these findings, the device was designed with a non-biomimetic anterior-posterior translation degree of freedom with a 10 cm range of motion which is primarily position-controlled to change the alignment of the prosthetic foot with the residual limb. The system is both mobile and tethered, with the batteries, actuators, and majority of electronics located in a small backpack. Mechanical loads are transmitted through cables to the prosthesis, minimizing the distal mass carriage required. We measured torque and force sensing accuracy, open loop actuator performance, closed loop torque and position control bandwidth, and torque and position tracking error during walking. The system is capable of producing up to 160 N-m of plantarflexion torque and 394 N of AP translation force with a closed loop control bandwidth of about 7 Hz in both degrees of freedom. Torque tracking during walking was accurate within about 10 N-m but position tracking was substantially affected by phase lag, possibly due to cable slack in the bidirectional mechanism. The prototype was capable of replicating our simulated prosthesis dynamics during gait and offers useful insights into the advantages and the practical considerations of using predictive biomechanical simulation as a design tool for wearable robots., Comment: 9 pages, 8 figures, 1 table

Understanding the nature of dark matter in the Universe is an important goal of modern cosmology. A key method for probing this distribution is via weak gravitational lensing mass-mapping - a challenging ill-posed inverse problem where one infers the convergence field from observed shear measurements. Upcoming stage IV surveys, such as those made by the Vera C. Rubin Observatory and Euclid satellite, will provide a greater quantity and precision of data for lensing analyses, necessitating high-fidelity mass-mapping methods that are computationally efficient and that also provide uncertainties for integration into downstream cosmological analyses. In this work we introduce MMGAN, a novel mass-mapping method based on a regularised conditional generative adversarial network (GAN) framework, which generates approximate posterior samples of the convergence field given shear data. We adopt Wasserstein GANs to improve training stability and apply regularisation techniques to overcome mode collapse, issues that otherwise are particularly acute for conditional GANs. We train and validate our model on a mock COSMOS-style dataset before applying it to true COSMOS survey data. Our approach significantly outperforms the Kaiser-Squires technique and achieves similar reconstruction fidelity as alternative state-of-the-art deep learning approaches. Notably, while alternative approaches for generating samples from a learned posterior are slow (e.g. requiring $\sim$10 GPU minutes per posterior sample), MMGAN can produce a high-quality convergence sample in less than a second.

The Emory Knee Radiograph (MRKR) dataset is a large, demographically diverse collection of 503,261 knee radiographs from 83,011 patients, 40% of which are African American. This dataset provides imaging data in DICOM format along with detailed clinical information, including patient-reported pain scores, diagnostic codes, and procedural codes, which are not commonly available in similar datasets. The MRKR dataset also features imaging metadata such as image laterality, view type, and presence of hardware, enhancing its value for research and model development. MRKR addresses significant gaps in existing datasets by offering a more representative sample for studying osteoarthritis and related outcomes, particularly among minority populations, thereby providing a valuable resource for clinicians and researchers., Comment: 16 pages

We present the results of Phase I of an ongoing review of Monte Carlo tools relevant for low-energy hadronic cross sections. This includes a detailed comparison of Monte Carlo codes for electron-positron scattering into a muon pair, pion pair, and electron pair, for scan and radiative-return experiments. After discussing the various approaches that are used and effects that are included, we show differential cross sections obtained with AfkQed, BabaYaga@NLO, KKMC, MCGPJ, McMule, Phokhara, and Sherpa, for scenarios that are inspired by experiments providing input for the dispersive evaluation of the hadronic vacuum polarisation., Comment: RadioMonteCarLow 2 Working Group report Phase I, 67 pages, 34 figures; references added and other minor modifications