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The Markov chain Monte Carlo (MCMC) method is widely used in various fields as a powerful numerical integration technique for systems with many degrees of freedom. In MCMC methods, probabilistic state transitions can be considered as a random walk in state space, and random walks allow for sampling from complex distributions. However, paradoxically, it is necessary to carefully suppress the randomness of the random walk to improve computational efficiency. By breaking detailed balance, we can create a probability flow in the state space and perform more efficient sampling along this flow. Motivated by this idea, practical and efficient nonreversible MCMC methods have been developed over the past ten years. In particular, the lifting technique, which introduces probability flows in an extended state space, has been applied to various systems and has proven more efficient than conventional reversible updates. We review and discuss several practical approaches to implementing nonreversible MCMC methods, including the shift method in the cumulative distribution and the directed-worm algorithm. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to investigate the effect of agility ladder training combined with plyometric or multidirection speed drills, on performance in young female volleyball players. Methods: Seventy-six young female volleyball players were randomly distributed into 3 maturity-matched groups: (1) the agility ladder + plyometric drills group, (2) the agility ladder + multidirection speed drills group, and (3) the control group. Both experimental groups followed a 6-week training program, twice weekly, in addition to the regular volleyball training sessions, while the control group participated only in the regular volleyball training sessions. Assessments pretraining and posttraining included countermovement jump, 20-m sprint, and agility T test. Results: Both experimental groups improved T-test performance (P <.005) but only agility ladder + multidirection speed drills group outperformed the control group (P <.05). Conclusions: Agility ladder training programs combined with either plyometric or speed drills can improve change of direction performance in young female volleyball players but only the combination of agility ladder with multidirection speed drills is more effective than volleyball training per se. The small effectiveness of these protocols may be attributed to the short training period, or to the fact that training elements were combined in a single session. This hypothesis remains to be further investigated. [ABSTRACT FROM AUTHOR]

In the study of stochastic systems, the committor function describes the probability that a system starting from an initial configuration x will reach a set B before a set A. This paper introduces an efficient and interpretable algorithm for approximating the committor, called the "fast committor machine" (FCM). The FCM uses simulated trajectory data to build a kernel-based model of the committor. The kernel function is constructed to emphasize low-dimensional subspaces that optimally describe the A to B transitions. The coefficients in the kernel model are determined using randomized linear algebra, leading to a runtime that scales linearly with the number of data points. In numerical experiments involving a triple-well potential and alanine dipeptide, the FCM yields higher accuracy and trains more quickly than a neural network with the same number of parameters. The FCM is also more interpretable than the neural net. [ABSTRACT FROM AUTHOR]

Global diabatic potential energy surfaces (PESs) of CH2+ are constructed using the neural network method with a specific function based on 18 213 ab initio points. The multi-reference configuration interaction method with the aug-cc-pVQZ basis set is adopted to perform the ab initio calculations. The topographical properties of the diabatic PESs are examined in detail. In general, the diabatic PESs provide an accurate quasi-diabatic representation. To validate the diabatic PESs, the dynamics studies of the C+(2P1/2, 3/2) + H2 (v0 = 0, j0 = 0) → H + CH+(X1Σ+) reaction are performed using the time-dependent wave packet method. The reaction probabilities, integral cross sections, differential cross sections, and rate constants are calculated and compared with the experimental and theoretical results. Non-adiabatic dynamics results are in good agreement with experimental data. In addition, the non-adiabatic effect in the C+(2P1/2, 3/2) + H2 reaction is significant due to the non-adiabatic results being obviously larger than adiabatic values. The reasonable non-adiabatic dynamics results indicate that present diabatic PESs can be recommended for any type of dynamics study. [ABSTRACT FROM AUTHOR]

Global diabatic potential energy surfaces (PESs) of CH2+ are constructed using the neural network method with a specific function based on 18 213 ab initio points. The multi-reference configuration interaction method with the aug-cc-pVQZ basis set is adopted to perform the ab initio calculations. The topographical properties of the diabatic PESs are examined in detail. In general, the diabatic PESs provide an accurate quasi-diabatic representation. To validate the diabatic PESs, the dynamics studies of the C+(2P1/2, 3/2) + H2 (v0 = 0, j0 = 0) → H + CH+(X1Σ+) reaction are performed using the time-dependent wave packet method. The reaction probabilities, integral cross sections, differential cross sections, and rate constants are calculated and compared with the experimental and theoretical results. Non-adiabatic dynamics results are in good agreement with experimental data. In addition, the non-adiabatic effect in the C+(2P1/2, 3/2) + H2 reaction is significant due to the non-adiabatic results being obviously larger than adiabatic values. The reasonable non-adiabatic dynamics results indicate that present diabatic PESs can be recommended for any type of dynamics study. [ABSTRACT FROM AUTHOR]

While the linear Pearson correlation coefficient represents a well-established normalized measure to quantify the inter-relation of two stochastic variables X and Y, it fails for multidimensional variables, such as Cartesian coordinates. Avoiding any assumption about the underlying data, the mutual information I(X, Y) does account for multidimensional correlations. However, unlike the normalized Pearson correlation, it has no upper bound (I ∈ [0, ∞)), i.e., it is not clear if say, I = 0.4 corresponds to a low or a high correlation. Moreover, the mutual information (MI) involves the estimation of high-dimensional probability densities (e.g., six-dimensional for Cartesian coordinates), which requires a k nearest-neighbor algorithm, such as the estimator by Kraskov et al. [Phys. Rev. E 69, 066138 (2004)]. As existing methods to normalize the MI cannot be used in connection with this estimator, a new approach is presented, which uses an entropy estimation method that is invariant under variable transformations. The algorithm is numerically efficient and does not require more effort than the calculation of the (un-normalized) MI. After validating the method by applying it to various toy models, the normalized MI between the Cα-coordinates of T4 lysozyme is considered and compared to a correlation analysis of inter-residue contacts. [ABSTRACT FROM AUTHOR]

We introduce a general definition of a quantum committor in order to clarify reaction mechanisms and facilitate control in processes where coherent effects are important. With a quantum committor, we generalize the notion of a transition state to quantum superpositions and quantify the effect of interference on the progress of the reaction. The formalism is applicable to any linear quantum master equation supporting metastability for which absorbing boundary conditions designating the reactant and product states can be applied. We use this formalism to determine the dependence of the quantum transition state on coherences in a polaritonic system and optimize the initialization state of a conical intersection model to control reactive outcomes, achieving yields of the desired state approaching 100%. In addition to providing a practical tool, the quantum committor provides a conceptual framework for understanding reactions in cases when classical intuitions fail. [ABSTRACT FROM AUTHOR]

We propose a theoretical approach to estimate the permeability coefficients of substrates (permeants) for crossing membranes from donor (D) phase to acceptor (A) phase by means of molecular dynamics (MD) simulation. A fundamental aspect of our approach involves reformulating the returning probability (RP) theory, a rigorous bimolecular reaction theory, to describe permeation phenomena. This reformulation relies on the parallelism between permeation and bimolecular reaction processes. In the present method, the permeability coefficient is represented in terms of the thermodynamic and kinetic quantities for the reactive (R) phase that exists within the inner region of a membrane. One can evaluate these quantities using multiple MD trajectories starting from phase R. We apply the RP theory to the permeation of ethanol and methylamine at different concentrations (infinitely dilute and 1 mol % conditions of permeants). Under the 1 mol% condition, the present method yields a larger permeability coefficient for ethanol (0.12 ± 0.01 cm s−1) than for methylamine (0.069 ± 0.006 cm s−1), while the values of the permeability coefficient are satisfactorily close to those obtained from the brute-force MD simulations (0.18 ± 0.03 and 0.052 ± 0.005 cm s−1 for ethanol and methylamine, respectively). Moreover, upon analyzing the thermodynamic and kinetic contributions to the permeability, we clarify that a higher concentration dependency of permeability for ethanol, as compared to methylamine, arises from the sensitive nature of ethanol's free-energy barrier within the inner region of the membrane against ethanol concentration. [ABSTRACT FROM AUTHOR]

Purpose: To assess the survival of double-crown-retained implant-and-tooth-supported removable partial dentures (DCR-ITSRPDs), evaluate abutment survival, and identify first aftercare measures. Materials and Methods: The influence of various factors on the survival of the DCR-ITSRPDs and the abutments were observed in this retrospective and clinical follow-up study using the Kaplan-Meier estimate. In addition, the first-required aftercare measure for each prosthesis was evaluated. Results: In total, 47 DCR-ITSRPDs were investigated (mean observation: 4.3 ± 3.8 years; max: 14.3 years), 3 of which (6.4%) had to be replaced. The survival probability for DCR-ITSRPDs was 100% at 5 years and 75% at 10 years. A total of 297 abutments (120 natural teeth and 177 dental implants) were observed, 22 of which (7.4%; 6 teeth and 16 implants) failed. The survival probability for teeth was 90.2% at the 5- and 10-year mark; for dental implants, it was 90.4% at 5 years and 76.3% at 10 years. Conclusions: DCR-ITSRPDs are a successful and durable treatment option for patients with substantially reduced residual dentitions. Both prostheses and abutments show good survival times after 5 and 10 years in function. The patient-associated factors tested showed no influence on the survival of DCR-ITSRPDs and abutments. Peri-implant infection was the decisive factor for abutment loss; therefore, regular dental prophylaxis and examinations are of major importance. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to compare the maximum and rapid force production of Spanish football players and explore the differences between age group and level of competition. Methods: A cross-sectional study was developed to evaluate the peak force (PF), relative PF, and rate of force development over 250 ms (RFD0−250) during the isometric midthigh pull between groups of football players based on age group (senior vs junior) and level of competition (national vs regional). Using a portable isometric rig, 111 football players performed 2 isometric midthigh-pull trials on a force plate. Two-way analysis of variance with Bonferroni post hoc correction was applied, and statistical significance was set at P ≤.05. The PF, relative PF, and RFD0−250 0, 25, 50, 75, and 100 percentiles were also calculated and descriptively reported, separated by age group and level of competition. Results: The analysis of variance revealed a significant main effect of the level of competition for the PF (P <.001), relative PF (P =.003), and RFD0−250 (P <.001). There was a significant main effect of age group for the PF (P <.001). There was a significant interaction effect of the age group × level of competition for relative PF (P =.014). National players were stronger than regional players on the PF and RFD0−250 (P <.001). Senior players were stronger than junior players for the PF (P <.001). Conclusions: Maximum and rapid force production are crucial for Spanish football players as they progress in both level of competition and age group. Practitioners should encourage young football players to prioritize strength development to improve their athletic performance. [ABSTRACT FROM AUTHOR]

Several types of dynamics at stationarity can be described in terms of a Markov jump process among a finite number N of representative sites. Before dealing with the dynamical aspects, one basic problem consists in expressing the a priori steady-state occupation probabilities of the sites. In particular, one wishes to go beyond the mere black-box computational tools and find expressions in which the jump rate constants appear explicitly, therefore allowing for a potential design/control of the network. For strongly connected networks admitting a unique stationary state with all sites populated, here we express the occupation probabilities in terms of a formula that involves powers of the transition rate matrix up to order N − 1. We also provide an expression of the derivatives with respect to the jump rate constants, possibly useful in sensitivity analysis frameworks. Although we refer to dynamics in (bio)chemical networks at thermal equilibrium or under nonequilibrium steady-state conditions, the results are valid for any Markov jump process under the same assumptions. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to investigate the peak performance characteristics of the world top-8 swimmers and the key factors involved in the journey toward achieving better peak performance. Methods: The results of the world top-8 swimmers from 2001 to 2022 were collected from the World Aquatics performance database. Progression to peak performance was tracked with individual quadratic trajectories (1191 cases). Utilizing k-means clustering to group competitive feature variables, this study investigated key developmental factors through a binary logistic regression model, using the odds ratio (OR) to represent whether a factor was favorable (OR > 1) or unfavorable (OR < 1). Results: Significant differences (P <.001) in the peak age between men (23.54/3.80) and women (22.31/4.60) were noticed, while no significant differences (P >.05) in the peak-performance window for both sexes appeared. Peak performance occurred at later ages for the sprint for both sexes, and women had a longer duration in peak-performance window for sprint (P <.05). Peak-performance occurred at later ages for the breaststroke and butterfly for both sexes (P <.05). Binary logistic regression revealed that high first-participation performance (OR = 1.502), high major-competition performance (OR = 4.165), early first-major-competition age (OR = 1.441), participation frequency above 4 times/year in both phase 2 (4.3–8.0 times/y, OR = 3.940; 8.1–20.0 times/y, OR = 5.122) and phase 3 (4.1–7.5 times/y: OR = 5.548; 7.7–15.0 times/y: OR = 7.526), and a career length of 10 years or more (10–15 y, OR = 2.102; 16–31 y, OR = 3.480) were favorable factors for achieving better peak performance. Conclusions: Peak performance characteristics varied across sex, swimming stroke, and race distance in the world top-8 swimmers. Meanwhile, the research indicated that certain specific developmental factors were key conditions for the world top-8 swimmers to achieve better peak performance in the future. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to cross-validate a recently proposed equation for the prediction of maximal oxygen uptake ( V ˙ O 2 max) in cycling exercise by using the average power output normalized by the body mass from a 5-minute time trial (RPO5-min) as the independent variable. Further, the study aimed to update the predictive equation using Bayesian informative prior distributions and meta-analysis. Methods: On different days, 49 male cyclists performed an incremental graded exercise test until exhaustion and a 5-minute time trial on a stationary cycle ergometer. We compared the actual V ˙ O 2 max with the predicted value obtained from the RPO5-min, using a modified Bayesian Bland–Altman agreement analysis. In addition, this study updated the data on the linear regression between V ˙ O 2 max and RPO5-min, by incorporating information from a previous study as a Bayesian informative prior distribution or via meta-analysis. Results: On average, the predicted V ˙ O 2 max using RPO5-min underestimated the actual V ˙ O 2 max by −6.6 mL·kg–1·min–1 (95% credible interval, −8.6 to −4.7 mL·kg–1·min–1). The lower and upper 95% limits of agreement were −17.2 (−22.7 to −12.3) and 3.8 (−1.0 to 9.5) mL·kg–1·min–1, respectively. When the current study's data were analyzed using the previously published data as a Bayesian informative prior distribution, the accuracy of predicting sample means was found to be better when compared with the data combined via meta-analyses. Conclusions: The proposed equation presented systematic bias in our sample, in which the prediction underestimated the actual V ˙ O 2 max. We provide an updated equation using the previous one as the prior distribution, which could be generalized to a greater audience of cyclists. [ABSTRACT FROM AUTHOR]

This study focuses on the stochastic modelling and analysis of a serial production network consisting of two manufacturing stations operating under a make-to-stock inventory policy. The outcome is a single type of product and every manufacturing station includes a machine and an output buffer. Both machines are gradually deteriorating during their operation. Deterioration results in a reduced production rate. Continuous-time Markov chain was used to model all the possible states the network transits over time due to the occurrence of certain events, such as client arrival, deterioration failure, production or repair completion. The structure of the Markov chain was thoroughly studied providing useful information, supporting the effort of numerical solving to determine the steady-state probabilities enabling the calculation of useful performance metrics like equipment availability, down time, idle time, utilisation and average inventory. Through a series of numerical experiments, the behaviour of the serial production network was examined while alternating its parameters. Interesting conclusions emerged regarding the factors affecting the operation of such production systems subjected to gradual deterioration. [ABSTRACT FROM AUTHOR]

Purpose: This study analyzed the sequences of actions in professional men and women padel players to identify common game patterns. Methods: The sample comprised 17,557 stroke-by-stroke actions (N = 1640 rallies) of the championship World Padel Tour. Multistep Markov chains were used to calculate the conditional probabilities of occurrence of actions during the rally. Results: Results revealed that men's and women's padel is mainly defined by 36 patterns constituting 55% and 63% of all actions in the game, respectively, with the 10 most common sequences accounting for 42% to 45% of the game. There were recurrent technical–tactical actions with specific offensive and defensive functions that were constantly reiterated during the rallies. In men, the use of smash, volley, bandeja, direct, back wall, back-wall lobs, and direct lobs followed a foreseeable pattern up to 8 lags, whereas women described predictable interactions for volley, bandeja, direct, lobs, and direct lobs up to 5 lags and for smash and back wall up to 4 lags. Conclusions: The ability of padel players to recall these patterns and enhance their anticipation skills may potentially improve their performance. These findings contribute to a better knowledge of professional padel game dynamics while providing coaches and players with useful information to optimize training and decision-making strategies. [ABSTRACT FROM AUTHOR]

The paper presents an analytical model for travel time evaluation in double-deep, triple-deep, quadruple-deep and fivefold-deep tier-captive shuttle-based storage and retrieval system (SBS/RS). Under the assumption of the deepest location rule for the storage process and the nearest neighbour rule for the retrieval process, the expressions for single-command and dual-command cycle times of the shuttle vehicle and elevator are developed, from which the SBS/RS performance can be estimated. The model based on the probability theory enables the evaluation of all individual times that make up the cycle times and assessment of the average number of totes relocated during a retrieval process. Special attention is devoted to the modelling of the relocation of totes which block access to the requested tote during the retrieval process. The validity of the analytical model is examined via the developed simulation model. The given case study shows that the proposed analytical travel time model results match the results of the simulation model. The presented modelling strategy could be applied to bigger system racking depths following the same modelling logic. [ABSTRACT FROM AUTHOR]

We spell out the paradigm of exact conditioning as an intuitive and powerful way of conditioning on observations in probabilistic programs. This is contrasted with likelihood-based scoring known from languages such as Stan. We study exact conditioning in the cases of discrete and Gaussian probability, presenting prototypical languages for each case and giving semantics to them. We make use of categorical probability (namely Markov and CD categories) to give a general account of exact conditioning, which avoids limits and measure theory, instead focusing on restructuring dataflow and program equations. The correspondence between such categories and a class of programming languages is made precise by defining the internal language of a CD category. [ABSTRACT FROM AUTHOR]

Purpose: As a multidisciplined combat sport, relationships between external and internal training loads and intensities of mixed martial arts (MMA) have not been described. The aim of this study was to determine the external loads and intensities of MMA training categories and their relationship to internal loads and intensities. Methods: Twenty MMA athletes (age = 23.3 [5.3] y, mass = 72.1 [7.2] kg, stature = 171.5 [8.4] cm) were observed for 2 consecutive weeks. Internal load and intensity (session rating of perceived exertion [sRPE]) were calculated using the Foster RPE for the session overall (sRPE-training load [TL]) and segmented RPE (segRPE-TL) for each training category: warm-up, striking drills, wrestling drills, Brazilian jiujitsu (BJJ) drills, striking sparring, wrestling sparring, BJJ sparring, and MMA sparring. External load and intensity were measured via Catapult OptimEye S5 for the full duration of each session using accumulated Playerload (PLdACC) and PLdACC per minute (PLdACC·min−1). Differences in loads between categories and days were assessed via Bayesian analysis of variance (BF10 ≥ 3). Predictive relationships between internal and external variables were calculated using Bayesian regression. Results: Session overall sRPE-TL = 448.6 (191.1) arbitrary units (AU); PLdACC = 310.6 (112) AU. Category segRPE-TL range = 33.8 (22.6) AU (warm-up) to 122.8 (54.6) AU (BJJ drills). Category PLdACC range = 44 (36.3) AU (warm-up) to 125 (58.8) AU (MMA sparring). Neither sRPE-TL nor PLdACC changed between days. PLdACC was different between categories. Evidence for regressions was strong-decisive except for BJJ drills (BF10 = 7, moderate). R2 range =.50 to.77, except for warm-up (R2 =.17), BJJ drills (R2 =.27), BJJ sparring (R2 =.49), and session overall (R2 =.13). Conclusions: While MMA training categories may be differentiated in terms of external load, overall session external load does not change within or between weeks. Resultant regression equations may be used to appropriately plan MMA technical/tactical training loads. [ABSTRACT FROM AUTHOR]

In response to a financial crisis, many organizations adjust their pay systems to reduce labor costs. In this research, we focus on the use of delayed pay (the postponement of employees' contractual compensation) and examine its effect on employee voluntary turnover outcomes. In a field study (Study 1) with data collected from the executive managers of 129 Chinese hotels experiencing a financial crisis caused by coronavirus disease 2019 (COVID‐19), we find a positive relationship between delayed pay and the voluntary turnover rate at the organizational level. In addition, this relationship becomes weaker when delayed pay consists of a larger proportion of pay‐for‐performance (PFP). We then conduct an experiment (Study 2) to extend our theoretical framework to the individual level, establish causality, and examine the underlying mechanism. The results show that the perceived negative instrumentality of stay (i.e., expected economic losses associated with staying in an organization) explains why individuals intend to leave organizations adopting delayed base pay but not delayed PFP. We further replicate these findings in a critical incident technique study (Study 3). We also discuss the theoretical and practical implications of these findings. [ABSTRACT FROM AUTHOR]

The probability of inserting, without overlap, a hard spherical particle of diameter σ in a hard-sphere fluid of diameter σ0 and packing fraction η determines its excess chemical potential at infinite dilution, μex(σ, η). In our previous work [R. L. Davidchack and B. B. Laird, J. Chem. Phys. 157, 074701 (2022)], we used Widom's particle insertion method within molecular dynamics simulations to obtain high precision results for μex(σ, η) with σ/σ0 ≤ 4 and η ≤ 0.5. In the current work, we investigate the behavior of this quantity at small σ. In particular, using the inclusion-exclusion principle, we relate the insertion probability to the hard-sphere fluid distribution functions and thus derive the higher-order terms in the Taylor expansion of μex(σ, η) at σ = 0. We also use direct evaluation of the excluded volume for pairs and triplets of hard spheres to obtain simulation results for μex(σ, η) at σ/σ0 ≤ 0.2247 that are of much higher precision than those obtained earlier with Widom's method. These results allow us to improve the quality of the small-σ correction in the empirical expression for μex(σ, η) presented in our previous work. [ABSTRACT FROM AUTHOR]

The three body fragmentation of methane dication has been studied using the technique of cold target recoil ion momentum spectroscopy. The process is initiated by impact of energetic Ar9+ ions on neutral methane and the data is subsequently collected in coincidence with Ar8+ projectile. By analysing the dissociation channels leading to (H + H+ + CH 2 + ) and (H + H 2 + + CH+) fragments, it is concluded that these fragments are formed in a sequential manner via formation of molecular intermediates CH 3 + and CH 2 + respectively. It is shown that these molecular intermediates carry a few eVs as their internal energies, part of which is released when they emit an H-atom with the open possibility that the final detected fragments may still be internally excited. This was accomplished by analysing the two-steps of the sequential process in their own native frames. For a molecular system having three-dimensional structure, our results prove to be an ideal example to highlight the importance of using native frames for correct interpretation of the obtained results. Our results indicate that the dissociation of methane dication can be a major source of production of H-atoms in addition to H+ fragments with the probability of the two being of similar order. [ABSTRACT FROM AUTHOR]

In this paper, we examine a supply chain consisting of a supplier with capital constraint and multiple retailers with no working capital. The retailers can get either trade credit from the supplier or loan from banks. All the retailers are differentiated by their credit scores, which measure the possibility that they default. We show that when the retailer's default probability is high compared with the marginal cost, the retailer cannot get financial support. If the retailers only get money from banks, the more reliable a retailer is, the higher the wholesale price the supplier may charge him. We also find out that the supplier has the motivation to provide trade credit even when the retailers can get money from banks. And no matter where the retailers get money from, when the initial capital is a little insufficient, the supplier will reduce the quantity of the products provided to all retailers. As the initial capital becomes less, the supplier will cut off all the supply to the lowest-score retailer first no matter whether the supplier undertakes the default risk or not. In other words, when the retailers are heterogeneous, for supplier, it is not always the more retailers, the better. [ABSTRACT FROM AUTHOR]

The returning probability (RP) theory, a rigorous diffusion-influenced reaction theory, enables us to analyze the binding process systematically in terms of thermodynamics and kinetics using molecular dynamics (MD) simulations. Recently, the theory was extended to atomistically describe binding processes by adopting the host–guest interaction energy as the reaction coordinate. The binding rate constants can be estimated by computing the thermodynamic and kinetic properties of the reactive state existing in the binding processes. Here, we propose a methodology based on the RP theory in conjunction with the energy representation theory of solution, applicable to complex binding phenomena, such as protein–ligand binding. The derived scheme of calculating the equilibrium constant between the reactive and dissociate states, required in the RP theory, can be used for arbitrary types of reactive states. We apply the present method to the bindings of small fragment molecules [4-hydroxy-2-butanone (BUT) and methyl methylthiomethyl sulphoxide (DSS)] to FK506 binding protein (FKBP) in an aqueous solution. Estimated binding rate constants are consistent with those obtained from long-timescale MD simulations. Furthermore, by decomposing the rate constants to the thermodynamic and kinetic contributions, we clarify that the higher thermodynamic stability of the reactive state for DSS causes the faster binding kinetics compared with BUT. [ABSTRACT FROM AUTHOR]

Ultrafast spectroscopy is a powerful technique that utilizes short pulses on the femtosecond time scale to generate and probe coherent responses in molecular systems. While the specific ultrafast methodologies vary, the most common data analysis tools rely on discrete Fourier transformation for recovering coherences that report on electronic or vibrational states and multi-exponential fitting for probing population dynamics, such as excited-state relaxation. These analysis tools are widely used due to their perceived reliability in estimating frequencies and decay rates. Here, we demonstrate that such "black box" methods for parameter estimation often lead to inaccurate results even in the absence of noise. To address this issue, we propose an alternative approach based on Bayes probability theory that simultaneously accounts for both population and coherence contributions to the signal. This Bayesian inference method offers accurate parameter estimations across a broad range of experimental conditions, including scenarios with high noise and data truncation. In contrast to traditional methods, Bayesian inference incorporates prior information about the measured signal and noise, leading to improved accuracy. Moreover, it provides estimator error bounds, enabling a systematic statistical framework for interpreting confidence in the results. By employing Bayesian inference, all parameters of a realistic model system may be accurately recovered, even in extremely challenging scenarios where Fourier and multi-exponential fitting methods fail. This approach offers a more reliable and comprehensive analysis tool for time-resolved coherent spectroscopy, enhancing our understanding of molecular systems and enabling a better interpretation of experimental data. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to determine the effects of a field-based priming session on perceptual, physiological, and performance responses in female rugby sevens athletes. Methods: Thirteen highly trained female rugby sevens players (age: 20.7 [2.0] y; height: 169.3 [4.8] cm; weight: 68.8 [7.9] kg) completed either a 20-minute field-based priming session or a control condition. Perceptual, physiological, and performance variables were collected at baseline (PRE) and 5 (POST5), 30 (POST30), and 120 minutes (POST120) postintervention. Data were analyzed using Bayesian mixed effects models. Results: The priming protocol had a larger increase in mental readiness (maximum a posteriori [MAP] = 20, 95% high-density intervals [HDI] = −4 to 42, probability of direction [PD]% = 95, % in region of practical equivalence [ROPE] = 9.7), physical readiness (MAP = 20.1, 95% HDI = −4.6 to 42.1, PD% = 93, % in ROPE = 10.6), and testosterone (MAP = 14.9, 95% HDI = 0.5 to 27.7, PD% = 98, % in ROPE = 5.6) than the control POST30. Cognitive performance decreased POST120 in the priming condition for congruent (MAP = 0.02, 95% HDI = −0.06 to 0.00, PD% = 95, % in ROPE = 6.4) and incongruent tasks (MAP = 0.00, 95% HDI = −0.07 to 0.00, PD% = 98, % in ROPE = 3.2) when compared with the control. Conclusions: Perceptual and physiological markers improved POST30 in the priming condition. Findings indicate that perceptual and physiological responses to priming were not coupled with performance improvements. Priming was not accompanied by perceptual, physiological, or performance improvements at POST120. [ABSTRACT FROM AUTHOR]

Summary: In this paper, we investigate the performance of a rate‐splitting multiple access (RSMA)‐based intelligent reflecting surface (IRS)‐assisted uplink hybrid satellite‐terrestrial network. We consider three different scenarios based on the channel phase knowledge at the IRS, namely, the ideal, partial, and blind cases. In the ideal case, the IRS has full knowledge of both the user‐to‐IRS and IRS‐to‐satellite channel phase information. In the partial case, the IRS has only the user‐to‐IRS channel phase information. Last, in the blind case, the IRS has no any knowledge of the phase information. We assume that the user‐to‐IRS channel follows Rician fading, and the IRS‐to‐satellite channel follows the shadowed Rician fading. The closed‐form tight outage probability expressions for all three scenarios are derived. The accuracy of the derivations is confirmed by simulation results. In addition, it is shown that the performance of the RSMA‐based system is superior to those of the conventional non‐orthogonal and orthogonal multiple access‐based systems with a small number of reflecting elements at high target rates. [ABSTRACT FROM AUTHOR]

Background: Happiness is crucial for human wellbeing. Nursing students encounter distinct challenges such as stress, burnout, and emotional exhaustion, which can negatively impact their mental health. Cultural and societal factors also influence happiness. Objective: This study conducted a comparative analysis of Big Five personality traits and emotional regulation (ER) as predictors of happiness among nursing students in Saudi Arabia and Jordan. Methods: This cross‐sectional study included 739 nursing students from Jordan and Saudi Arabia who were selected using a multistage sampling technique. The instruments utilized in this study were the short version of the Big Five Inventory for assessing personality, Oxford Happiness Inventory for measuring happiness levels, and Emotional Regulation Questionnaire for evaluating ER. To identify the predictors of student happiness, stepwise regression analysis was conducted, and cross‐country comparisons were made using a "pool analysis" method. Results: The findings indicated that 62.1% of the participants reported moderate levels of happiness, whereas 36.0% reported high levels. There were significant differences in happiness levels between Jordan and Saudi Arabia (p = 0.003), with Jordanian students reporting lower happiness levels. In Saudi Arabia, there were significant variations based on age (p = 0.049) and academic year (p = 0.013). Multiple regression analysis revealed that higher agreeableness, extraversion, and conscientiousness were positively associated with happiness while openness had a weak association. Conversely, higher Neuroticism, being in Jordan, and being male were negatively associated with happiness. Nominal regression analysis indicated that extraversion and agreeableness are significant predictors of higher levels of happiness, whereas neuroticism is associated with lower levels of happiness. Furthermore, males and non‐Saudis were more likely to report lower levels of happiness. Conclusion: This study revealed notable determinants of happiness among nursing students in Saudi Arabia and Jordan. ER, Big Five personality traits, and demographic factors play influential roles. Overall, the robust regression model emphasized the dependability of these findings, providing valuable insights for nursing education and interventions aimed at improving student wellbeing. From a practical standpoint, these findings can guide the development of personalized mental health support programs and interventions designed to enhance the happiness and wellbeing of nursing students. [ABSTRACT FROM AUTHOR]

Recent studies have focused on identifying the optimal seismic and energy upgrading interventions, among different alternatives, for poorly performing existing buildings. Most of such studies use detailed methodologies to assess the seismic and energy performance of buildings, which are time and computationally demanding, making it nearly unfeasible for practitioners and decision-makers to use them, rendering practice-oriented approaches extremely needed. To overcome the current limitations of more research-oriented methods, this study employs different available simplified approaches, namely SPO2FRAG, cloud-based capacity spectrum method and the Italian seismic risk classification guidelines (Sismabonus), to estimate some of the variables considered when using a multi-criteria decision-making (MCDM) framework to select the optimal combined retrofitting strategy, among a set of different options. To this end, a case-study school building was selected and four seismic retrofitting solutions, combined with three energy-based interventions, were identified. The performance of the building, in its as-built and retrofitted conditions, was analysed considering both simplified and detailed approaches for the estimation of two of the seismic-related variables, namely annual probability of failure and expected annual losses. Such simplified and refined estimates were used as MCDM input, comparing the ranking of retrofitting combined alternatives obtained in both cases, demonstrating the suitability of the proposed simplified methodology for engineering practice. [ABSTRACT FROM AUTHOR]

In this article, the complete convergence for the partial sum of the moving average process { X n = ∑ i = − ∞ ∞ a i Y i + n , n ≥ 1 } is established under some mild conditions, where { Y i , − ∞ < i < ∞ } is a sequence of extended negatively dependent and identically distributed random variables that is stochastically dominated by a random variable Y under a sub-linear expectation (Ω , H , E ̂) , and { a i , − ∞ < i < ∞ } is an absolutely summable sequence of real numbers. These conclusions promote and improve the corresponding results of moving the average process under extended negatively dependent random variables from the traditional probability space to the sub-linear expectation space. [ABSTRACT FROM AUTHOR]

In this article, we utilize the contrast function of the integrated diffusion process to derive parameter contrast estimators for the Cox-Ingersoll-Ross integrated diffusion process and discuss the asymptotic properties of the estimators using the mixing properties of the process. We first give the tail probability exponential inequality of the mixing long-span high-frequency data. Then, applying this inequality, we prove the strong consistency of the contrast estimators for the drift parameters and diffusion parameter of the CIR integrated diffusion process. In order to obtain these asymptotic properties, we require relatively low order r of the negative power moment E | X t − 1 | r of the diffusion process. In the existing literature, r > 9 is required in order to obtain weak consistency of the estimators. However, in our theorems, only r > 2 is required for the strong consistency of the diffusion parameter estimator, while r > 4 for the strong consistency of the drift parameter estimators. In the simulation analysis, we use the Euler discretization algorithm and the Milstein discretization algorithm, and the results show that the optimal sampling interval is around n − 1 / 3 . We use the daily log price data of the CSI 300 Index to estimate the CIR integrated diffusion model and construct a Bootstrap prediction model for the log price. The results show that the model has a good predictive performance. [ABSTRACT FROM AUTHOR]

General biased data frequently arises in various observational studies, either naturally or by design. The data is not representative of the target population, highlighting the importance of developing methods that address general biased data. This article primarily focuses on the estimation of treatment effects with general biased data. By employing the inverse probability weighting technique, a unified semiparametric estimating equation is constructed to derive an unbiased estimator. The large sample properties of the resulting estimator are established under some mild regularity conditions. Simulation studies and applications to the Oscar data and the heart transplant survival data are presented. [ABSTRACT FROM AUTHOR]

This article discusses random hypergraphs with varying hyperedge sizes, admitting large hyperedges with size tending to infinity, and heavy-tailed limiting hyperedge size distributions. The main result describes a threshold for the random hypergraph to be connected with high probability, and shows that the average hyperedge size suffices to characterise connectivity under mild regularity assumptions. Especially, the connectivity threshold is in most cases insensitive to the shape and higher moments of the hyperedge size distribution. Similar results are also provided for related random intersection graph models. [ABSTRACT FROM AUTHOR]

In opportunistic network, the regular connectivity of nodes and their individual conditions significantly influence message transmission. To address this, we propose an improved spray and wait routing algorithm based on stable transmission capacity evaluation of nodes (referred to as STCESW), which is derived from traditional Prophet and spray and wait algorithms but surpasses them. STCESW incorporates network models that consider node connection stability and transmission capacity, aiming to enhance the update and punishment formulas for node delivery probability. Furthermore, it combines the residual message buffer size of nodes with the angle between motion directions of nodes to determine more efficient and extensive message spraying in the network. The simulation results clearly indicate that STCESW significantly outperforms the other three enhanced algorithms in both SPMBM and RWP. It demonstrates its robust performance in terms of delivery probability, showing an increase ranging from 2% to 87% across diverse node buffer sizes or simulation time intervals. Additionally, it compromises slightly on delivery latency while maintaining relatively stable message latency and buffer time. [ABSTRACT FROM AUTHOR]

Simple graphical displays such as icon arrays and tree diagrams have been proposed for communicating health risks and supporting informed decisions. The UK’s National Health Service (NHS) uses tree diagrams to communicate the chances of different cervical cancer screening results, but their effectiveness has not been compared to icon arrays. We conducted a well-powered longitudinal experiment involving 3,100 UK women eligible for cervical screening (25–64 years) to examine the effectiveness of icon arrays to communicate possible cervical screening results, relative to the UK NHS’s tree diagram and to a numerical-only format. We also examined whether the presence (vs. absence) of explanatory text referring to different types of results (i.e. distinguishing between HPV positive results with vs. without abnormal cervical cells) moderated effects of presentation format. Presentation format did not affect verbatim or gist knowledge of probabilities at initial assessment (i.e. immediately after participants viewed the displays), but icon arrays were associated with better gist knowledge of absolute magnitudes than tree diagrams and numerical-only formats at 1-month follow-up. Participants exposed to icon arrays also perceived lower likelihood of adverse screening results and reported stronger screening intentions at initial assessment. For displays without explanatory text, icon arrays were also associated with more positive user evaluations and less negative affective reactions than tree diagrams at initial assessment. Overall, our findings suggest that icon arrays support enduring knowledge of approximate magnitudes of probabilities and are better suited than tree diagrams for communicating possible screening results. [ABSTRACT FROM AUTHOR]

Differential evolution (DE) has attracted widespread attention due to its outstanding optimization performance and ease of operation, but it cannot avoid the dilemmas of premature convergence or stagnation when faced with complex optimization problems. To reduce the probability of such difficulties for DE, we sort out the factors that influence the balance between global exploration and local exploitation in the DE algorithm, and we design a novel DE variant (abbreviated as PISRDE) by integrating the corresponding influence factors through a periodic intervention mechanism and a systematic regulation mechanism. The periodic intervention mechanism divides the optimization operations of PISRDE into routine operation and intervention operation, and it balances global exploration and local exploitation at the macro level by executing the two operations alternately. The systematic regulation mechanism treats the involved optimization strategies and parameter settings as an organic system for targeted design, to balance global exploration and local exploitation at the meso or micro level. To evaluate and verify the optimization performance of PISRDE, we employ seven DE variants with excellent optimization performance to conduct comparison experiments on the IEEE CEC 2014 and IEEE CEC 2017 benchmarks. The comparison results indicate that PISRDE outperforms all competitors overall, and its relative advantage is even more significant when dealing with high-dimensional and complex optimization problems. Schematic design philosophy of PISRDE [ABSTRACT FROM AUTHOR]

We propose the linearly adaptive cross entropy loss function. This is a novel measure derived from the information theory. In comparison to the standard cross entropy loss function, the proposed one has an additional term that depends on the predicted probability of the true class. This feature serves to enhance the optimization process in classification tasks involving one-hot encoded class labels. The proposed one has been evaluated on a ResNet-based model using the CIFAR-100 dataset. Preliminary results show that the proposed one consistently outperforms the standard cross entropy loss function in terms of classification accuracy. Moreover, the proposed one maintains simplicity, achieving practically the same efficiency to the traditional cross entropy loss. These findings suggest that our approach could broaden the scope for future research into loss function design. [ABSTRACT FROM AUTHOR]

We examine the gender gap in faculty promotion at the University of Geneva. After building a new measure of research quality that has no gender bias (i.e. men and women have, on average, the same level of research quality after we control for disciplines), we find that conditional on research quality, discipline and place where the PhD was obtained, women are 11 percent less likely to get promoted. The gender gap is almost three times larger for promotion from assistant to associate professor, suggesting that the mechanism at play is stronger for junior faculty. The gender gap is explained by the fact that an equal increase in research quality leads to a smaller increase in women's probability of promotion. [ABSTRACT FROM AUTHOR]

This paper studies the bounded confidence model on growing fully-mixed populations. In this model, in addition to the usual opinion clusters, significant secondary clusters of smaller size appear systematically, while those secondary clusters appear erratically and include much fewer agents when the population is fixed. Through simulations, we derive the bifurcation diagram of the growing population model and compare it to the diagram obtained with an evolving probability density instead of agents, and with their equivalent having a fixed population. Our tests, when changing the usual bounded confidence function into a smooth bounded confidence function, suggest that these secondary clusters are mainly generated by a different mechanism when the population is growing than when it is fixed. [ABSTRACT FROM AUTHOR]

In this work, we study conditional monotone cumulants and additive convolution in the shuffle-algebraic approach to non-commutative probability. We describe c-monotone cumulants as an infinitesimal character and identify the c-monotone additive convolution as an associative operation in the set of pairs of characters in the dual of a double tensor Hopf algebra. In this algebraic framework, we understand previous results on c-monotone cumulants and prove a combinatorial formula that relates c-free and c-monotone cumulants. We also identify the notion of t-Boolean cumulants in the shuffle-algebraic approach and introduce the corresponding notion of t-monotone cumulants as a particular case of c-monotone cumulants. [ABSTRACT FROM AUTHOR]

How many copies of a fixed odd cycle, C2 m + 1 ${C}_{2m+1}$, can a planar graph contain? We answer this question asymptotically for m ∈{2 , 3 , 4 } $m\in \{2,3,4\}$ and prove a bound which is tight up to a factor of 3/2 for all other values of m $m$. This extends the prior results of Cox and Martin and of Lv, Győri, He, Salia, Tompkins, and Zhu on the analogous question for even cycles. Our bounds result from a reduction to the following maximum likelihood question: which probability mass μ $\mu $ on the edges of some clique maximizes the probability that m $m$ edges sampled independently from μ $\mu $ form either a cycle or a path? [ABSTRACT FROM AUTHOR]

Resurgence is a transient recovery of a previously extinguished target response following a worsening of reinforcement conditions for an alternative response. Laboratory studies with nonhuman animals typically assess resurgence in free‐operant situations where subjects can freely emit responses. The purpose of the current study was to investigate whether resurgence would be observed in a discrete‐trial procedure where only a single response could occur in each trial, using rats as subjects. The experiment consisted of three phases, and each session ended after 200 trials. All trials began with the insertion of target and alternative levers and ended once a response was emitted. In Phase 1, both target and alternative responses were reinforced with a probability of .25. In Phase 2, the target response was extinguished while still reinforcing the alternative response with a probability of .25. Finally, resurgence was tested by placing the alternative response on extinction. All rats showed robust resurgence in this highly constrained discrete‐trial situation. We also found that the latencies of resurged target responses differed from those in Phase 1. Overall, the present discrete‐trial procedure could produce reliable resurgence as with typical free‐operant procedures and has several potential benefits for studying resurgence. [ABSTRACT FROM AUTHOR]

Binary logistic regression is one of the most widely used statistical tools. The method uses odds, log odds, and odds ratios, which are difficult to understand and interpret. Understanding of logistic regression tends to fall down in one of three ways: (1) Many students and researchers come to believe that an odds ratio translates directly into relative probabilities. (2) Alternatively, they learn that coefficients tell us whether the variables make the outcome more or less likely, without knowing how to interpret changes in the odds. (3) They may be instructed in how to calculate predicted probabilities, but the additional steps are too complicated for them to follow. Our key aim is to highlight and correct the common mistake of confusing differences in odds with relative risks. Simply reporting the odds ratio is unhelpful, however, so we describe an easy method of estimating probabilities for both binary and continuous variables. [ABSTRACT FROM AUTHOR]

Dose–response relationships are important in assessing the efficacy and potency of compounds, which can usually be characterized by a 4-parameter logistic (4-PL) model estimating EC50, slope factor, lower asymptote, and upper asymptote. EC50, the concentration of a compound that induces a response halfway between the baseline and maximum, is a key quantity to evaluate compound potency. For multi-donor dose–response data, it is often of interest to estimate the overall EC50 (i.e. the average EC50 of the population of donors) and its 95% confidence interval (CI). A few multi-donor EC50 estimation methods have been proposed in the literature. Jiang and Kopp-Schneider (2014) systematically compared the meta-analysis approach and the nonlinear mixed-effects approach and concluded that the meta-analysis approach is simple and robust to summarize EC50 estimates from multiple experiments, especially suited in the case of a small number of experiments, while the nonlinear mixed-effects approach has the issue of convergence failures probably due to overparameterization. In this article, we propose a modification of the nonlinear mixed-effects approach by using the stochastic approximation expectation-maximization (SAEM) algorithm to estimate model parameters and using multiple starting points to search for globally optimal values, which can substantially alleviate the issue of convergence failures even for small number of donors (e.g. n = 3), and achieve a smaller absolute median bias and better coverage probability of 95% confidence interval than the meta-analysis approach when the number of donors is not too small (e.g. n ≥ 7). [ABSTRACT FROM AUTHOR]

This study explores the impact of the Domestic Violence Disclosure Scheme (DVDS) on repeat victimisation among applicants. By analysing all ‘Right to Ask’ applications to Avon & Somerset Constabulary in 2021, the study investigates the extent of prior domestic abuse victimisation and the influence of disclosure decisions on subsequent reports. The findings reveal that 80% of applicants had prior victimisation records, and disclosures were made in 53% of the cases. The probability of subsequent abuse reports increased significantly for those with prior victimisation when disclosures were made, highlighting the need for robust support mechanisms post-disclosure. The study complements debate around the theoretical tension between empowerment and responsibilisation within DVDS and calls for enhanced support systems and rigorous outcome evaluations. These results suggest that while DVDS aims to protect victims, its effectiveness in reducing victimisation requires further empirical validation and comprehensive support strategies. [ABSTRACT FROM AUTHOR]

Summary: The future wireless communication networks (beyond 5G) are intended to provide seamless connectivity, higher data rates, and lower latency. The intelligent reflecting surface (IRS) promises extended network coverage. The non‐orthogonal multiple access (NOMA) technique provides higher spectral efficiency and supports a larger number of users. In general, the cell‐edge users far from the base station are affected by severe fading, which may result in an outage. To overcome this issue, we propose an IRS‐aided device‐to‐device (D2D)‐enabled two cells coordinated NOMA system in which a common cell‐edge user acts as D2D receiver. The cell‐edge user receives the signals from near users, IRSs, and both base stations to achieve better diversity. We analyze the outage probability of cell‐edge user, while all the fading channels are assumed Nakagami‐ m and obtain a closed‐form expression at higher signal‐to‐noise ratios. We develop an algorithm to find the ergodic capacity of the cell‐edge user. We validate the mathematical expressions with simulation results and see a substantial improvement in outage performance over the existing systems. [ABSTRACT FROM AUTHOR]

Background: In recent years, limited studies have evaluated the development of cultural awareness, sensitivity, skills, communication and competence among nursing students using different models and curricula. Objectives: This study aimed to evaluate the effectiveness of a new internationally developed curriculum for transcultural nursing education. Methods: This mixed methods study was conducted on nursing students (n = 83) who attended a transcultural nursing course from 2021 to 2022 during the fall semester. A paired samples test was used to compare total scores, and the related-samples Wilcoxon signed-rank test was used to compare subscale scores. Results: The vast majority (94.0%) of the participants mentioned Islam as their religion. Turkish was the mother tongue of 91.6% of them, while 10.8% were able to speak English and 6.0% were able to speak Kurdish fluently. The mean score for the achievement of cultural competence subdimension posttest was significantly greater (p < 0.001). Posttest mean scores for challenges and barriers in providing culturally competent care subdimensions were significantly lower (p = 0.003). The mean score on the culturally sensitive communication subdimension pretest was 21.00 ± 4.76, and the mean score on the posttest increased to 23.02 ± 6.05, which was a statistically significantly greater difference (p = 0.024). According to the qualitative results of our study, five main themes were analyzed: transcultural nursing as an opportunity, transcultural nursing as a didactic process, transcultural nursing as a professional field, transcultural care as a safe environment, and transcultural care as an obligation. Conclusions: In this study, after a semester of continuing education, nursing students developed respect for cultural diversity, cultural competence, and culturally sensitive communication. [ABSTRACT FROM AUTHOR]

Background: Osteoporosis is a common condition that increases the risk of fracture and mortality. In Taiwan, clinical guidelines recommend pharmaceutical therapy for patients with a T-score of ≤ − 2.5; however, Taiwan's National Health Insurance (NHI) only covers these medications for those with a history of fragility fractures. This gap in coverage necessitates a discussion of out-of-pocket treatment options. To address this, we provided an integrated care program with patient education and shared decision-making by nurse case managers specializing in osteoporosis. We evaluated whether education by nurse case managers influences patients with a T-score ≤ − 2.5, who are not covered by the NHI, to choose out-of-pocket pharmaceutical therapy. Methods: We retrospectively reviewed medical records of patients who underwent bone density scanning at our hospital between January 2014 and December 2021. We identified 4,462 patients with a T-score of ≤ − 2.5 who were ineligible for NHI-covered anti-osteoporotic therapy and analyzed trends in out-of-pocket medication use. Since the integrated care program began in 2018, we evaluated whether education by nurse case managers between 2018 and 2021 influenced patients' decisions to pay out-of-pocket for therapy. After the implementation of the integrated care program, we identified 2,910 patients with a T-score ≤ -2.5 who were ineligible for NHI-covered anti-osteoporotic therapy. Of these, 640 opted for out-of-pocket treatment, while 2,270 chose conservative care. After a 1:1 propensity score match based on age and sex, logistic regression was used to analyze the impact of nurse case manager education on these decisions. Results: Between 2014 and 2021, 888 of the 4,462 patients chose out-of-pocket pharmaceutical therapy. Before the implementation of the integrated care program and patient education by nurse case managers (2014–2017), 16% of the patients opted to pay out-of-pocket for anti-osteoporotic therapy. After the program was implemented (2018–2021), the rate increased significantly to 22% (P < 0.001). A multivariate logistic regression model showed that a history of osteoarthritis (adjusted odds ratio = 1.576; P = 0.009) and education provided by the nurse case managers (adjusted odds ratio = 5.044; P < 0.001) were significantly associated with choosing out-of-pocket therapy. Conclusions: Education from nurse case managers significantly increased the likelihood of patients choosing out-of-pocket anti-osteoporotic therapy in our hospital, thereby bridging the gap between clinical guidelines and NHI reimbursement criteria. [ABSTRACT FROM AUTHOR]