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The origin of cancers is associated with etiology as well as therapeutics. Several studies reveal that malignancies in children can originate in utero. However, a diagnostic approach to distinguish between cancers initiated pre- or postnatally is absent. Here we identified a transcriptional factor FEV (fifth Ewing variant) that was expressed in fetal hematopoietic cells and became silent after birth. We characterized that FEV was essential for the self-renewal of hematopoietic stem cells (HSCs). We next found that FEV was expressed in most infant leukemia samples, but seldom in adult samples, in accord with the known prenatal origins of the former. We further determined the majority of pediatric acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML) were FEV positive. Moreover, FEV knockdown markedly impaired the leukemia-propagating ability of leukemic stem cells. We therefore identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin. It may also provide a tractable therapeutic target.

The production of non-phi K+K- pairs by protons of 2.83 GeV kinetic energy on C, Cu, Ag, and Au targets has been investigated using the COSY-ANKE magnetic spectrometer. The K- momentum dependence of the differential cross section has been measured at small angles over the 0.2--0.9 GeV/c range. The comparison of the data with detailed model calculations indicates an attractive K- -nucleus potential of about -60 MeV at normal nuclear matter density at a mean momentum of 0.5 GeV/c. However, this approach has difficulty in reproducing the smallness of the observed cross sections at low K- momenta., Comment: 7 pages, 5 figures, 1 table

The first measurement of the three-body photodisintegration of polarized $^{3}\mathrm{He}$ using a circularly polarized photon beam has been performed at incident energies of 12.8 and 14.7 MeV. This measurement was carried out at the high-intensity $\ensuremath{\gamma}$-ray source located at Triangle Universities Nuclear Laboratory. A high-pressure $^{3}\mathrm{He}$ target, polarized via spin exchange optical pumping with alkali metals, was used in the experiment. The spin-dependent double- and single-differential cross sections from $\stackrel{P\vec}{{}^{3}\text{He}}(\stackrel{P\vec}{\ensuremath{\gamma}},n)pp$ for laboratory angles varying from ${30}^{\ensuremath{\circ}}$ to ${165}^{\ensuremath{\circ}}$ are presented and compared with state-of-the-art three-body calculations. The data reveal the importance of including the Coulomb interaction between protons in the three-body calculations.

The transverse spin correlations ${A}_{x,x}$ and ${A}_{y,y}$ have been measured in the $\stackrel{P\vec}{d}\stackrel{P\vec}{p}\ensuremath{\rightarrow}{p}_{\text{spec}}{{pp}}_{s}{\ensuremath{\pi}}^{\ensuremath{-}}$ reaction at COSY-ANKE at 353 MeV per nucleon. Here ${{pp}}_{s}$ denotes a proton-proton pair with low excitation energy, which is dominantly in the ${}^{1}{S}_{0}$ state. By measuring three protons in the final state it was possible to extract events where there was a spectator proton ${p}_{\text{spec}}$ so that the reaction could be interpreted in terms of quasifree $\stackrel{P\vec}{n}\phantom{\rule{0.16em}{0ex}}\stackrel{P\vec}{p}\ensuremath{\rightarrow}{{pp}}_{s}{\ensuremath{\pi}}^{\ensuremath{-}}$. The proton and neutron analyzing powers in this reaction were also deduced from this data set by averaging over the polarizations of the deuteron beam and hydrogen target, respectively. The values of ${A}_{y}$ were shown to be consistent with a refined analysis of our earlier results obtained with a polarized proton incident on a deuterium target. Taking these data in combination with our previous measurements of the differential cross sections and analyzing powers in the $\stackrel{P\vec}{p}p\ensuremath{\rightarrow}{{pp}}_{s\phantom{\rule{0.16em}{0ex}}}{\ensuremath{\pi}}^{0}$ reaction, a more robust partial wave decomposition was achieved. Three different acceptable solutions were found, and the only way of resolving this ambiguity without further theoretical input would be through a measurement of the mixed spin-correlation parameter ${A}_{x,z}$.

The $pp\ensuremath{\rightarrow}pp{K}^{+}{K}^{\ensuremath{-}}$ reaction was measured below the $\ensuremath{\phi}$ threshold at a beam energy of 2.568 GeV using the COSY-ANKE magnetic spectrometer. By assuming that the four-body phase space is distorted only by the product of two-body final-state interactions, fits to a variety of one-dimensional distributions permit the evaluation of differential and total cross sections. The shapes of the distributions in the $Kp$ and $Kpp$ invariant masses are reproduced only if the ${K}^{\ensuremath{-}}p$ interaction is even stronger than that found at higher energy. The cusp effect in the ${K}^{+}{K}^{\ensuremath{-}}$ distribution at the ${K}^{0}{\overline{K}}^{0}$ threshold is much more clear and some evidence is also found for coupling between the ${K}^{\ensuremath{-}}p$ and ${\overline{K}}^{0}n$ channels. However, the energy dependence of the total cross section cannot be reproduced by considering only a simple product of such pairwise final-state interactions.

The first measurement of the three-body photodisintegration of longitudinally polarized $^{3}\mathrm{He}$ with a circularly polarized $\ensuremath{\gamma}$-ray beam was carried out at the High Intensity $\ensuremath{\gamma}$-ray Source facility located at Triangle Universities Nuclear Laboratory. The spin-dependent double-differential cross sections and the contributions from the three-body photodisintegration to the $^{3}\mathrm{He}$ Gerasimov-Drell-Hearn integrand are presented and compared with state-of-the-art three-body calculations at the incident photon energies of 12.8 and 14.7 MeV. The data reveal the importance of including the Coulomb interaction between protons in three-body calculations.

The first measurement of the three-body photodisintegration of longitudinally polarized (3)He with a circularly polarized γ-ray beam was carried out at the High Intensity γ-ray Source facility located at Triangle Universities Nuclear Laboratory. The spin-dependent double-differential cross sections and the contributions from the three-body photodisintegration to the (3)He Gerasimov-Drell-Hearn integrand are presented and compared with state-of-the-art three-body calculations at the incident photon energies of 12.8 and 14.7 MeV. The data reveal the importance of including the Coulomb interaction between protons in three-body calculations.

The production of phi mesons in proton collisions with C, Cu, Ag, and Au targets has been studied via the phi -> K+K- decay at an incident beam energy of 2.83 GeV using the ANKE detector system at COSY. For the first time, the momentum dependence of the nuclear transparency ratio, the in-medium phi width, and the differential cross section for phi meson production at forward angles have been determined for these targets over the momentum range of 0.6 - 1.6 GeV/c. There are indications of a significant momentum dependence in the value of the extracted phi width, which corresponds to an effective phi-N absorption cross section in the range of 14 - 21 mb., 9 pages, 5 figures

We present a summary of a recent workshop held at Duke University on Partonic Transverse Momentum in Hadrons: Quark Spin-Orbit Correlations and Quark-Gluon Interactions. The transverse momentum dependent parton distribution functions (TMDs), parton-to-hadron fragmentation functions, and multi-parton correlation functions, were discussed extensively at the Duke workshop. In this paper, we summarize first the theoretical issues concerning the study of partonic structure of hadrons at a future electron-ion collider (EIC) with emphasis on the TMDs. We then present simulation results on experimental studies of TMDs through measurements of single spin asymmetries (SSA) from semi-inclusive deep-inelastic scattering (SIDIS) processes with an EIC, and discuss the requirement of the detector for SIDIS measurements. The dynamics of parton correlations in the nucleon is further explored via a study of SSA in D (`D) production at large transverse momenta with the aim of accessing the unexplored tri-gluon correlation functions. The workshop participants identified the SSA measurements in SIDIS as a golden program to study TMDs in both the sea and valence quark regions and to study the role of gluons, with the Sivers asymmetry measurements as examples. Such measurements will lead to major advancement in our understanding of TMDs in the valence quark region, and more importantly also allow for the investigation of TMDs in the sea quark region along with a study of their evolution., Comment: 44 pages 23 figures, summary of Duke EIC workshop on TMDs accepted by EPJA

From our measured value of the stimulated emission cross section for 4F3/2–4I13/2 transition of Nd3+ ion in YAlO3 crystal as well as the results of continuous wave (cw) and pulsed 1341.4 nm Nd:YAP lasers, it can be seen that Nd:YAP is an excellent 1300 nm laser crystal. In our laboratory cw output power of 195.8 W at 1341.4 nm with an overall efficiency of 1.43% and pulsed output energy of 5.1 J at 1341.4 nm with an overall efficiency of 2.02% have been achieved by using this kind of crystal.

The possibility of simultaneous multiple wavelength lasing in various neodymium host crystals such as Nd:YAG, Nd:YLF, Nd:BEL, and Nd:YAP has been analyzed by the ‘‘oscillation condition.’’ It is shown that this kind of laser can be realized in all the described crystals in pulsed state, but only achieved in the Nd:YAP crystal in continuous‐wave state. On the basis of the analyzed results, we have achieved cw simultaneous multiple wavelength lasing in Nd:YAP crystal for the first time at both 1.0795 and 1.3414 μm.