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Fecal microbiota transplantation (FMT) is revolutionizing the treatment of gastrointestinal disorders by leveraging the gut microbiome in innovative ways. This systematic review evaluates the clinical effectiveness and safety of FMT across various medical conditions, offering insights into its therapeutic potential and limitations. A comprehensive search of PubMed, Web of Science, Scopus, Embase, and ClinicalTrials.gov from January 2000 to December 2023 identified 97 relevant studies on FMT's efficacy, safety, and microbiome changes after eliminating duplicates. FMT has demonstrated high success rates, particularly in treating recurrent and refractory Clostridium difficile infections (CDI), with up to 90% effectiveness, establishing it as a primary treatment for antibiotic-resistant cases. FMT’s applications are expanding to inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, as well as metabolic disorders and neuropsychiatric conditions. Remission rates for IBD range from 37-45%, with outcomes influenced by donor characteristics, stool preparation, and disease subtype. with mild, self-limiting side effects such as transient diarrhea and abdominal cramping. However, rare serious adverse events underscore the need for rigorous donor screening and standardized preparation protocols to mitigate risks. FMT’s ability to restore healthy gut flora highlights its promise in both gastrointestinal and systemic disease management. However, further research is essential to establish optimized procedures, standardized guidelines, and long-term safety data to facilitate its integration into mainstream medical practice.

Green-synthesised silver nanoparticles (AgNP) used to treat antibiotic-resistant bacteria. This article addresses the synthesis and characterization of silver nanoparticles (AgNP) based on Acacia nilotica plant extract, as well as their antibacterial efficacy against human illnesses. The information of homogeneous, spherical shaped AgNP with an average size of 23.65 nm was confirmed by XRD, SEM, EDAX, TEM, UV-Vis spectroscopy, and FTIR analysis. The effectiveness of the produced AgNP against various bacteria was tested using MIC and zone of inhibition experiments, showing impressive inhibitory effects. These findings imply that the environmentally friendly production method and potent antibacterial properties of the biosynthesized AgNP hold promise for upcoming bio-related uses.