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The objective of this paper was to examine the adsorption of the antibiotic ciprofloxacin (CIP) in a calcined Verde-lodo (CVL) clay-packed fixed-bed system. The characterization study of the fresh and contaminated clay indicated filling of the clay pores by the CIP (pore volume decreased from 65.4 to 31.1 cm³ g–¹) and did not evidence significant changes in the clay texture. The fixed-bed system reached a breakthrough adsorption capacity of 0.038 mmol g–¹ (12.6 mg g–¹) and a mass transfer zone of 4.29 cm. Five mathematical models were fitted to the breakthrough curves, and the dual-site diffusion displayed the best fit to the experimental data (R² > 0.98). The adsorption performance of CIP was compared to that of the antibiotic ofloxacin, reported in the literature, in which density functional theory (DFT) computations were performed to clarify the particularities of the adsorption of both compounds onto CVL clay.

This study investigated the feasibility of H2 production by acid corrosion, employing a by-product from the fertilizer industry (Hexafluorsilic acid - H2SiF6) and waste iron sources. Different masses of metal from three different sources: iron powder (waste from metal workshops), steel wool and rebar (construction waste), were reacted with various proportions of H2SiF6 with HCl. The influence of the variables was evaluated by factorial design, verifying greater production of H2 for materials with higher contact areas. The lowest production was observed for construction industry waste (rebar) probably due to the presence of protective films and lower contact area. The gas produced was analyzed by gas chromatography and was found to consist only of H2 (up to 99%) and air. The results indicate a promising application of H2SiF6, which is generated in large quantities during phosphate fertilizer production and has few commercial applications. The method proposed is promising, it does not emit toxic or polluting gases, contributing to the sustainable generation of H2.

Orientadores: Paulo Kharmandayan, Alfio José Tincani Dissertação (mestrado profissional) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas Resumo: Introdução: A técnica cirúrgica microvascular para realização de retalhos microcirúrgicos foi sendo aprimorada nos últimos 30 anos, com taxas de sucesso reportadas entre 94% a 99%. A despeito dessa evolução, complicações vasculares (tromboses venosa, arterial e hematomas) nos pedículos dos retalhos microcirúrgicos podem levar à isquemia e congestão. Sinais de má perfusão tecidual, quando identificados precocemente, possibilitam intervenção imediata, elevando as taxas de sobrevivência do retalho. A partir da década de 1980, as tentativas de padronizar uma técnica ideal de monitoramento objetivando minimizar as perdas aumentaram. O modelo ideal seria não invasivo, confiável, objetivo, reprodutível por qualquer indivíduo treinado, com monitoramento contínuo para todos os tipos de retalho e economicamente viável. O modelo preconizado nos dias de hoje ainda consiste na observação clínica: avaliação da cor do tecido, temperatura do retalho, sangramento dérmico (pin prick test) e enchimento capilar, apesar de serem baseados em variáveis subjetivas e dependentes de avaliação pessoal. Métodos auxiliares vêm ganhando espaço visando serem mais objetivos (ex.: clearence de hidrogênio, ultrassom Doppler portátil, ultrassom Doppler implantável, temperatura por infravermelho, avaliação da oxigenação tecidual, microdiálise, angiografia com verde de indocianina). Todavia ainda não há consenso sobre um monitoramento de retalhos microcirúrgicos que seja tão sensível, específico e que promova uma reintervenção cirúrgica mais eficaz que o monitoramento clínico. Objetivo:?Criação e elaboração de estudo piloto de um protocolo de monitoramento pós-operatório dos pacientes candidatos à reconstrução microcirúrgica do Hospital de Clínicas da UNICAMP, adequado ao Serviço, visando minimizar a taxa de perda destes retalhos. Método:?Revisão de dados da literatura sobre monitoramento pós-operatório de retalhos microcirúrgicos para criação de um protocolo adequado ao Serviço utilizando a observação clínica acrescida de dois métodos auxiliares de interpretação mais objetiva: o ultrassom Doppler portátil e o termômetro infravermelho. Elaboração de estudo piloto sequencialmente. Resultados:?Após revisão de dados da literatura (PubMed e LILACS) com os termos "FREE FLAPS and MONITORING" foram identificados 188 artigos, dos quais 4 revisões sistemáticas e 20 estudos prospectivos. Tomando como base os 24 artigos (revisões sistemáticas e estudos prospectivos), foi criado um protocolo de monitoramento para o Serviço, que consistiu em: 1) avaliação do estado hemodinâmico do paciente anteriormente ao monitoramento propriamente dito; 2) realização do monitoramento do retalho por meio da observação clínica, ultrassom Doppler portátil e termômetro infravermelho; 3) registro fotográfico do padrão de perfusão do retalho. No estudo piloto foram acompanhados três pacientes (setembro a dezembro de 2019), com reintervenção precoce em um caso e salvamento do retalho. Conclusão: A criação do protocolo institucional de monitoramento pós-operatório dos retalhos microcirúrgicos utilizando a associação da observação clínica e de dois métodos auxiliares de interpretação (ultrassom Doppler portátil e termômetro infravermelho) adequou-se às características deste Serviço e foi reprodutível pelos residentes treinados após estudo piloto. É necessária a aplicação do protocolo para um maior número de pacientes Abstract: Introduction: The microvascular surgical technique for performing microsurgical flaps has improved over the last 30 years, with reported success rates ranging from 94% to 99%. Despite this evolution, vascular complications (venous, arterial thrombosis and hematomas) in the microsurgical flap pedicles may lead to ischemia and congestion. Signs of poor tissue perfusion, when identified early, allow immediate intervention for flap salvage attempt, increasing flap survival rates. Starting in the 1980¿s, attempts to standardize an ideal monitoring technique to minimize flap losses have increased. The ideal model would be non-invasive, reliable, objective, reproducible, with continuous monitoring for all types of flaps and economically feasible. The gold-standard method until today consists of clinical observation: evaluation of tissue color, flap temperature, dermal bleeding (pin prick test) and capillary filling, despite being based on subjective variables and dependent on personal evaluation. New auxiliary methods can provide more objective readings (eg. hydrogen clearance, portable Doppler ultrasound, implantable Doppler ultrasound, infrared temperature, assessment of tissue oxygenation, microdialysis, indocyanine green angiography). However, there is still no consensus on which objective microsurgical flap monitoring method is as sensitive and specific as clinical monitoring. Objective: Creation and design of a postoperative free flap monitoring protocol for patients who will undergo microsurgical flap reconstruction at UNICAMP (Hospital de Clínicas da UNICAMP), suitable to the Plastic Surgery Service, aiming to minimize free flap complications. Method: Review of literature on postoperative monitoring methods with development of a free flap monitoring protocol suitable to the UNICAMP Plastic Surgery Service based on clinical observation associated to two auxiliary objective reading methods: the portable Doppler ultrasound and the infrared thermometer. Results: The review of literature (PubMed and LILACS) with the terms "FREE FLAPS and MONITORING" retrieved 188 articles, with 4 systematic reviews and 20 prospective studies. Based on the 24 later articles, a monitoring protocol was created, which consisted of: 1) assessment of the patient's hemodynamic status prior to the monitoring itself; 2) flap monitoring through clinical observation, portable Doppler ultrasound and infrared thermometer; 3) photographic record of the flap perfusion pattern. Three patients were included in the initial study (September to December 2019), one of them required early take back for flap salvage. Conclusion: The creation of an institutional protocol for postoperative free flap monitoring using a combination of clinical observation and two auxiliary objective interpretation methods (portable Doppler ultrasound and infrared thermometer) was suitable to the characteristics of the Service and was reproducible by trained residents after an initial study. A larger number of patients is necessary for further assessment of the efficacy of the proposed protocol Mestrado Eficácia e Efetividade de Testes Diagnósticos e Protocolos de Tratamento em Saúde Mestra em Ciências

The present paper presents the study of (1) the optimization of electrochemical-free chlorine production using an experimental design approach, and (2) the application of the optimum conditions obtained for the application in photo-assisted electrochemical degradation of simulated textile effluent. In the experimental design the influence of inter-electrode gap, pH, NaCl concentration and current was considered. It was observed that the four variables studied are significant for the process, with NaCl concentration and current being the most significant variables for free chlorine production. The maximum free chlorine production was obtained at a current of 2.33 A and NaCl concentrations in 0.96 mol dm−3. The application of the optimized conditions with simultaneous UV irradiation resulted in up to 83.1% Total Organic Carbon removal and 100% of colour removal over 180 min of electrolysis. The results indicate that a systematic (statistical) approach to the electrochemical treatment of pollutants c...

O aumento crescente no consumo de antibioticos e a presenca destes em efluentes e um problema emergente, de forma que metodos alternativos de remocao devem ser estudados. Dessa forma, neste projeto realizou-se testes de afinidade adsortiva com diferentes antibioticos, utilizando diversas argilas, para, posteriormente, determinar a intensidade dos efeitos gerados por cada variavel avaliada no processo. O antibitotico ofloxacino com a argila verde-lodo calcinada apresentou maior remocao (98,87%) dos ensaios realizados.

The need for efficient extraction of plant constituents with a high yield and purity and limitations to conventional extraction techniques that are limited by mass transfer, has resulted in the development of new extraction processes. Sonochemistry involves cavitation induced by pressure fluctuations generated by ultrasound waves in a liquid medium. Ultrasound can be effectively used to increase the yield and the mass transfer rate in solid-liquid extraction processes. The present work employed a factorial design 33 and a central composite design (PCC) for the extraction of Schinus Terebinthifolius. It is possible to verify an optimum point for the extraction (35.24%) for a mass of 13.49 g and an extraction time of 2 h, at 60 ºC. La necesidad de una extracción efectiva de plantas con alto rendimiento y pureza, además del hecho de que las técnicas de extracción convencionales están limitadas por la resistencia a la transferencia de masa, ha resultado en el desarrollo de nuevos procesos de extracción. La ecoquímica implica la cavitación inducida por las fluctuaciones de presión generadas por las ondas de ultrasonido en un medio líquido. El ultrasonido se puede usar efectivamente para aumentar el rendimiento y la tasa de transferencia de masa, en los procesos de extracción sólido-líquido. El presente trabajo empleó un diseño factorial 33 y un diseño compuesto central (PCC) para la extracción de Schinus terebinthifolius. Es posible verificar un punto óptimo para la extracción (35.24%) con una masa de 13.49 gy un tiempo de extracción de 2 h, a 60 ºC. A necessidade de extração eficaz de plantas com alto rendimento e pureza, além do fato das técnicas convencionais de extração serem limitadas pela resistência de transferência de massa resultou no desenvolvimento de novos processos de extração. A Sonoquímica, envolve a cavitação induzida pelas flutuações de pressão geradas pelas ondas de ultrassom em um meio líquido. O ultrassom pode ser eficazmente utilizado para aumentar o rendimento e a taxa de transferência de massa, em processos de extração sólido-líquido. O presente trabalho empregou um planejamento fatorial 33 e um planejamento composto central (PCC) para a extração de Schinus terebinthifolius. Sendo possível verificar um ponto ótimo para a extração (35,24%) com a massa de 13,49 g e tempo de extração de 2 h, à 60 ºC.

Ciprofloxacin (CIP) is the most prescribed antibiotic worldwide and is considered an emerging contaminant. The adsorption of ciprofloxacin onto calcined Verde-lodo (CVL) bentonite clay in a static system was evaluated in this study. CVL clay was characterized by Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Thermogravimetric Analysis, and Zeta analyzer before and after application to examine the adsorption mechanism. Statistical techniques of experimental design were used to determine the best conditions to maximize the adsorption capacity of CIP. Static system tests were performed to evaluate the kinetics, isotherm, and thermodynamics of adsorption. The system reached a maximum Langmuir removal capacity (25 °C) of 114.4 mg g−1 and CVL clay displayed considerable reuse capacity with heat treatment at 500 °C. The ability for regeneration and high removal capacity of CVL provides a promising strategy to mitigate emerging contaminants present in wastewater.

Due to the increasing consumption of antibiotic agents and the fact that conventional effluent treatment methods are inefficient in removing these compounds, new and more effective treatment processes need to be investigated and improved. This work evaluated the adsorption of the emerging contaminant ofloxacin (OFL, antibiotic) in static and dynamic systems using calcined Verde-lodo (CVL) bentonite clay. The use of CVL bentonite clay for this purpose has not been investigated, furthermore, there are no reported studies regarding OFL adsorption in a fixed bed system. The molecular structure of ofloxacin was obtained by molecular simulation showing a stable and minimum local energy structure. The characterization study before and after the adsorption process indicated the presence of OFL in the CVL clay. The analyzes indicated that the CVL clay exhibits a lamellar structure with some roughness, with pores of 80,000 nm larger than macropores (>50 nm). In addition, the thermogravimetric analysis indicated that the clay is thermally stabile up to 1000 °C. External mass transfer resistance and pseudo-second-order models best described the kinetic data. The Dubinin-Radushkevick model was best adjusted to the equilibrium assays, indicating heterogeneous adsorbent surface. The system reached a maximum Langmuir adsorption capacity (55 °C) of 0.445 mmol g−1 (160.81 mg g−1). Fixed bed assays indicated the occurrence of multilayer adsorption. Under operating conditions of 0.4 mL min−1 and 0.05 mmol L−1, the system operated for 140 h with practically 100% removal until the breakthrough time was achieved. The clay showed high reuse capacity, with removal efficiency >93% after 3 cycles.

The present work had as its objective, the evaluation of the combination of electrochemical, photochemical and sonrochemical techniques (sono-electrochemical photoassisted) applied to degradation of cytarabine (chemotherapeutic drug) in a simulated urine that continues with creatinine and laboratory research. The paper involved laboratory research with both a qualitative and quantitative approach. A continuous-flow filter-press electrochemical reactor was employed using Dimensionally Stable Anode (DSA® - Ti/Ru0.3Ti0.7O2) as the electrode material. A 23 factorial design was used to optimize the degradation of organic compounds contained in artificial urine (creatinine and urea) together with cytarabine, varying applied current, retention time and flow rate, the response variable was total organic carbon (TOC) removal. Additionally, UHPLC analyses demonstrated the removal of ancitabine (precursor of cytarabine), corroborating with the data obtained by the from the experimental design. The use of artificial urine as an electronic support interferes with the electrochemical process, taking TOC to high levels. However, it was observed that there was significant removal of the organic load present in the effluent solution, even when a more complex degradation matrix is used (artificial urine). El objetivo del presente fue evaluar la combinación de técnicas electroquímicas, fotoquímicas y sonoquímicas (foto-asistidas del sueño-electroquímicas) aplicadas a la degradación de citarabina (fármaco quimioterapéutico) en orina simulada que contiene creatinina y urea, a través de investigaciones de laboratorio cualitativas y cuantitativas. Se empleó un reactor electroquímico de filtro-prensa de flujo continuo utilizando Ánodo Dimensionalmente Estable (DSA® - Ti / Ru0.3Ti0.7O2) como material del electrodo. El diseño factorial 23 se utilizó para optimizar mejores degradaciones de compuestos orgánicos contenidos en orina artificial (creatinina y urea) junto con citarabina, corriente eléctrica variable, tiempo de retención y velocidad de flujo, la respuesta variable fue el carbono orgánico total (TOC). Además, los análisis de UHPLC demostraron la eliminación de ancitabina (precursor de citarabina), corroborando con los datos obtenidos por el diseño experimental. El uso de orina artificial como soporte electrónico interfiere con el proceso electroquímico, llevando el TOC a niveles altos. Sin embargo, se observó que hubo una eliminación significativa de la carga orgánica presente en la solución del efluente, incluso cuando se usa una matriz de degradación más compleja (orina artificial). O presente trabalho teve como objetivo a avaliação da combinação de técnicas eletroquímicas, fotoquímicas e sonroquímicas (sono-eletroquímica fotoassistida) aplicadas à degradação da citarabina (droga quimioterapêutica) na urina simulada que continha creatinina e uréia, através de uma pesquisa laboratorial quali e quantitativa. Um reator eletroquímico de filtro prensa de fluxo contínuo foi empregado usando o ânodo dimensionalmente estável (DSA® - Ti / Ru0.3Ti0.7O2) como material do eletrodo. O delineamento fatorial 23 foi utilizado para otimizar melhores degradações dos compostos orgânicos contidos na urina artificial (creatinina e uréia) juntamente com a citarabina, variando a corrente elétrica, o tempo de retenção e a vazão; a resposta variável foi o carbono orgânico total (TOC). Além disso, as análises UHPLC demonstraram a remoção da ancitabina (precursora da citarabina), corroborando com os dados obtidos pelo delineamento experimental. O uso da urina artificial como suporte eletrônico interfere no processo eletroquímico, levando o TOC a níveis elevados. No entanto, observou-se que houve remoção significativa da carga orgânica presente na solução de efluente, mesmo quando é utilizada uma matriz de degradação mais complexa (urina artificial).

The aim of the present study was to investigate the electrochemical formation of free chlorine species (HOCl/ClO−) and their subsequent use for the degradation of the pesticide atrazine. Initially, the process of electrochemical-free chlorine production was investigated using a bench-scale electrochemical flow-cell. The most significant variables (electrolyte concentration ([NaCl]) and inter-electrode gap) of the process were obtained using a 23 factorial design and the optimum process conditions (1.73 mol L−1 and 0.56 cm) were determined by a central composite design. Following optimization of free chlorine production, three degradation techniques were investigated, individually and in combination, for atrazine degradation: electrochemical, photochemical and sonochemical. The method using the techniques in combination was denominated sono-photo-assisted electrochemical degradation. Constant current assays were performed and the sono-photo-assisted electrochemical process promoted more efficient r...

The influence of chloride ion concentration during the photo-assisted electrochemical degradation of simulated textile effluent, using a commercial Ti/Ru0.3Ti0.7O2 anode, was evaluated. Initially, the effect of applied current and supporting electrolyte concentration on the conversion of chloride ions to form reactive chlorine species in 90 min of experiment was analyzed in order to determine the maximum production of reactive chlorine species. The optimum conditions encountered (1.5 A and 0.3 mol dm(-3) NaCl) were subsequently employed for the degradation of simulated textile effluent. The efficiency of the process was determined through the analysis of chemical oxygen demand (COD), total organic carbon (TOC), of the presence of organochlorine products and phytotoxicity. Photo-assisted electrochemical degradation was more efficient for COD and TOC removal than the electrochemical technique alone. With simultaneous UV irradiation, a reduced quantity of reactive chlorine was produced, indicating that photolysis of the chlorine species led to the formation of hydroxyl radicals. This fact turns a simple electrochemical process into an advanced oxidation process.

OBJECTIVE: Mechanical ventilation is frequently necessary, in which case the use of an endotracheal tube is mandatory. The tube has an inflatable balloon in its distal extremity, whose aim is, among other functions, an efficient arterialization. However, serious injuries in the place of contact of the balloon with the trachea can be frequent. Some studies point out that balloons with permanent pressure may reduce this complication. Nevertheless, air scape, expressed by the inspiratory (IV) and expiratory volume (EV) variation (Δ IV-EV), may occur, possibly leading to hypoxemia. Thus, the goal of this study was to verify the efficiency of a modified endotracheal tube on arterializations compared to the traditional endotracheal tube. METHODS: The modified endotracheal tube presents intermittent insufflation, with three drillings in the internal region of the cuff, allowing for insufflation in the inspiratory phase of the mechanical ventilation. Three animals were used for the control group, with a cuff pressure of 30 cmH2O, and seven pigs had the modified endotracheal tube. Each animal was kept under mechanical ventilation (FIO2=0.21) for 6 hours. Arterial and venous gases were measured every three hours (T0; T3; T6). RESULTS: The gases confirmed the lack of hypoxia between the Groups, with a difference in the ΔIV-EV at T0 (P=0.0486). CONCLUSIONS: In this study, the lack of hypoxia showed the efficiency of the modified endotracheal tube. However, new studies are necessary, particularly in diseased lungs, in order to evaluate the real efficiency of the mentioned device on the pulmonary gas exchange.

Tradicionalmente, em muitos departamentos sao organizados nucleos de discussao denominados Clubes de Revista sobre tematicas envolvendo artigos e descobertas dentro da comunidade cientifica. Nesses nucleos, os envolvidos sao familiarizados com artigos cientificos, possuem um prazo para estuda-los, para depois apresenta-los e discuti-los. Os artigos pre-selecionados sao, em sua maioria, recentes e nao relacionados. Neste trabalho, a participacao no Clube de Revista da UFTM – conhecido como BBS – colaborou de forma notoria na construcao do conhecimento, foi um grande incentivador a maior procura por iniciacao cientifica e os alunos participantes estavam muito mais preparados para o desenvolvimento de projetos quando comparados aos demais alunos que nao haviam participado. Ainda quanto a Iniciacao Cientifica, o BBS promoveu uma maior interacao tanto entre orientador e orientado, como entre os alunos participantes, incrementando o conhecimento cientifico atualizado, na fundamentacao dos artigos cientificos utilizados, alem de possibilitar o treino dos participantes nas diferentes formas de explorar figuras, tabelas, graficos.

Introduction: The inflation pressure of the endotracheal tube cuff can cause ischemia of the tracheal mucosa at high pressures; thus, it can cause important tracheal morbidity and tracheal microaspiration of the oropharyngeal secretion, or it can even cause pneumonia associated with mechanical ventilation if the pressure of the cuff is insufficient. Objective: In order to investigate the effectiveness of the RUSCH® 7.5 mm endotracheal tube cuff, this study was designed to investigate the physical and mechanical aspects of the cuff in contact with the trachea. Methods: For this end, we developed an in vitro experimental model to assess the flow of dye (methylene blue) by the inflated cuff on the wall of the artificial material. We also designed an in vivo study with 12 Large White pigs under endotracheal intubation. We instilled the same dye in the oral cavity of the animals, and we analyzed the presence or not of leakage in the trachea after the region of the cuff after their deaths (animal sacrifice). All cuffs were inflated at the pressure of 30 cmH2O. Results: We observed the passage of fluids through the cuff in all in vitro and in vivo experimental models. Conclusion: We conclude that, as well as several other cuff models in the literature, the RUSCH® 7.5 mm tube cuffs are also not able to completely seal the trachea and thus prevent aspiration of oropharyngeal secretions. Other prevention measures should be taken. Introdução: A pressão de insuflação do balonete (cuff) do tubo endotraqueal tanto pode causar isquemia de mucosa traqueal em pressões elevadas, e assim ocasionar morbidade traqueal importante, quanto pode causar microaspiração traqueal de secreção de orofaringe ou, ainda, ocasionar pneumonia associada à ventilação mecânica, caso a pressão do balonete seja insuficiente. Objetivo: A fim de investigar a eficácia do balonete do tubo endotraqueal RUSCH® 7,5mm, este estudo foi desenhado para investigar aspectos físicos e mecânicos do balonete em contato com a traqueia. Métodos: Para isto, foi desenvolvido modelo experimental in vitro para avaliar o escoamento de corante (azul de metileno) pelo balonete insuflado na parede de material artificial. Também foi desenhado estudo in vivo com 12 porcos da raça Large-White sob intubação endotraqueal. Foi instilado o mesmo corante na cavidade oral do animal e após óbito (sacrifício do animal) foi analisada a presença ou não de vazamento deste na traqueia pós-região do balonete. Todos os balonetes foram insuflados na pressão de 30 cmH2O. Resultados: Houve passagem de fluidos pelo balonete em todos os modelos experimentais in vitro e in vivo. Conclusão: Podemos concluir que, assim como diversos outros modelos de balonetes na literatura, balonetes do tubo RUSCH® 7,5mm também não são capazes de vedar completamente a traqueia e com isso prevenir aspiração de secreções orofaríngeas. Outras medidas para a prevenção devem ser tomadas.

Contamination of water by toxic and/or recalcitrant species has great environmental impacts. In this context, Advanced Oxidation Processes (AOPs) - technologies that principally use the hydroxyl radical (HO●) for oxidation - have emerged as promising alternatives in treating urban and industrial wastewaters. This study reviewed the literature on POAs and presented data regarding the efficiency of these processes in pollutant degradation, comparing the theoretical reasoning and its industrial applications. The fundamentals and major applications of AOPs (chemical, photochemical, electrochemical, sonochemical and ozone-based processes), as well as their advantages and disadvantages, are described in this review. AOPs have been considered an effective alternative from a technical, economic and environmental viewpoint for the degradation of pollutants in effluents and industrial wastewater, despite having limitations such as high cost of available energy sources, development of new low-cost catalytic materials and construction of full-scale reactors. It is greatly important to the industrial application of AOPs to optimize the effectiveness of these factors.

CONTEXT: Lymphedema consists of extracellular fluid retention caused by lymphatic obstruction. In chronic forms, fat and fibrous tissue accumulation is observed. Genital lymphedema is a rare condition in developed countries and may have primary or acquired etiology. It generally leads to urinary, sexual and social impairment. Clinical treatment usually has low effectiveness, and surgical resection is frequently indicated. CASE REPORT: We report a case of a male-to-female transgender patient who was referred for treatment of chronic genital lymphedema. She had a history of pelvic radiotherapy to treat anal cancer and of liquid silicone injections to the buttock and thigh regions for esthetic purposes. Radiological examinations showed signs both of tissue infiltration by liquid silicone and of granulomas, lymphadenopathy and lymphedema. Surgical treatment was performed on the area affected, in which lymphedematous tissue was excised from the scrotum while preserving the penis and testicles, with satisfactory results. Histopathological examination showed alterations compatible with tissue infiltration by exogenous material, along with chronic lymphedema. CONCLUSION: Genital lymphedema may be caused by an association of lesions due to liquid silicone injections and radiotherapy in the pelvic region. Cancer treatment decisions for patients who previously underwent liquid silicone injection should take this information into account, since it may represent a risk factor for radiotherapy complications.