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1. Organspende und Explantation

Author

Biel, Torsten, Gehmlich, Karsten, Wilkosch, Karoline, Barreiros, Ana Paula, Rahmel, Axel, Logemann, Frank, Koppert, Wolfgang, editor, Eiß, Markus, editor, Nitschmann, Sirka, editor, Rabenbauer, Stefan, editor, and Liehn, Margret, editor

Published
2024
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3. Organspende und Transplantation

Author

Biel, Torsten, Gehmlich, Karsten, Wilkosch, Karoline, Barreiros, Ana Paula, Rahmel, Axel, Liehn, Margret, editor, Richter, Heike, editor, and Kasakov, Leonid, editor

Published
2023
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8. A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program

Author

Tieken, I., Haasnoot, G., van Meel, M., Rump, L.C., Rosenkranz, A., Horn, S., Margreiter, R., Schneeberger, S., Oberbauer, R., Pohanka, E., Függer, F., Mühlbacher, F., Berlakovich, G., Meurisse, M., Weekers, L., Ysebaert, D., Wissing, K.M., Mikhalski, D., Mourad, M., van Biesen, W., Kuypers, D., Floege, J., Anthuber, M., Viebahn, R., Schenker, P., Budde, K., Pratschke, J., Zidek, W., Melchior, S., Woitas, R., Strassburg, C.H., Hugo, C., Wirth, M., Schiffer, M., Kribben, A., Pisarski, P., Fichtner-Feigl, S., Haubitz, M., Weimer, R., Weithofer, P., Fornara, P., Fisher, L., Sester, U., Zeier, M., Kliem, V., Klempnauer, l, Grimm, M.O., Kunzendorf, U., Stippel, D., Arns, W., Mönch, C., Nitschke, M., Bartels, M., Krämer, B., Kruger, B., Heemann, U., Werner, J., Hoyer, J., Wolters, H.H., Suwelack, B., Lutz, J., Banas, B., Hakenberg, O., Olbricht, C.J., Kalus, M., Schwenger, V., Nadalin, S., Schröppel, B., Lopau, K., Seelen, M.A.J., Berger, S.P., de Fijter, J.W., van der Linden, S.J., Christiaans, M.H.L., van de Wetering, J., van Zuilen, A.D., Bemelman, F., Nurmohamed, A., Hilbrands, L., de Fijter, Johan, Dreyer, Geertje, Mallat, Marko, Budde, Klemens, Pratschke, Johann, Klempnauer, Jürgen, Zeier, Martin, Arns, Wolfgang, Hugo, Christian, Rump, Lars-Christian, Hauser, Ingeborg, Schenker, Peter, Schiffer, Mario, Grimm, Marc-Oliver, Kliem, Volker, Olbricht, Christoph J., Pisarski, Przemyslaw, Banas, Bernhard, Suwelack, Barbara, Hakenberg, Oliver, Berlakovich, Gabriela, Schneeberger, Stefan, van de Wetering, Jacqueline, Berger, Stefan, Bemelman, Frederike, Kuypers, Dirk, Heidt, Sebastiaan, Rahmel, Axel, Claas, Frans, Peeters, Patrick, Oberbauer, Rainer, Heemann, Uwe, and Krämer, Bernhard K.

Published
2023
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9. Supplemented ERA-EDTA Registry data evaluated the frequency of dialysis, kidney transplantation, and comprehensive conservative management for patients with kidney failure in Europe

Author

Stel, Vianda S., de Jong, Rianne W., Kramer, Anneke, Andrusev, Anton M., Baltar, José M., Barbullushi, Myftar, Bell, Samira, Castro de la Nuez, Pablo, Cernevskis, Harijs, Couchoud, Cécile, De Meester, Johan, Eriksen, Bjørn O., Gârneaţă, Liliana, Golan, Eliezer, Helve, Jaakko, Hemmelder, Marc H., Hommel, Kristine, Ioannou, Kyriakos, Jarraya, Faiçal, Kantaria, Nino, Kerschbaum, Julia, Komissarov, Kirill S., Magaz, Ángela, Mercadal, Lucile, Ots-Rosenberg, Mai, Pálsson, Runólfur, Rahmel, Axel, Rydell, Helena, Savino, Manuela, Seyahi, Nurhan, Slon Roblero, Maria F., Stojceva-Taneva, Olivera, van der Tol, Arjan, Vazelov, Evgueniy S., Ziginskiene, Edita, Zurriaga, Óscar, Vanholder, Raymond C., Massy, Ziad A., and Jager, Kitty J.

Published
2021
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11. Donor heart and lung procurement: A consensus statement

Author

Copeland, Hannah, Hayanga, J.W. Awori, Neyrinck, Arne, MacDonald, Peter, Dellgren, Goran, Bertolotti, Alejandro, Khuu, Tam, Burrows, Fay, Copeland, Jack G., Gooch, Danyel, Hackmann, Amy, Hormuth, David, Kirk, Christa, Linacre, Virginia, Lyster, Haifa, Marasco, Silvana, McGiffin, David, Nair, Priya, Rahmel, Axel, Sasevich, Michael, Schweiger, Martin, Siddique, Aleem, Snyder, Timothy J., Stansfield, William, Tsui, Steven, Orr, Yishay, Uber, Patricia, Venkateswaran, Rajimyer, Kukreja, Jasleen, and Mulligan, Michael

Published
2020
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13. Kidney Transplantation after Rescue Allocation - the Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Muehlfeld, Anja, Antonia, Bouts, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Huüser, Norbert, and Heemann, Uwe

Published
2021
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15. Approaching the Families of Potential Deceased Organ Donors: An Overview of Regulations and Practices in Council of Europe Member States

Author

Mihály, Sándor, primary, Smudla, Anikó, additional, Dominguez-Gil, Beatriz, additional, Pérez, Alicia, additional, Procaccio, Francesco, additional, Cozzi, Emanuele, additional, López Fraga, Marta, additional, Avsec, Danica, additional, Rahmel, Axel, additional, Forsythe, John, additional, Immer, Franz, additional, Jushinskis, Janis, additional, and Manara, Alex, additional

Published
2023
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17. A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program

Author

de Fijter, Johan, primary, Dreyer, Geertje, additional, Mallat, Marko, additional, Budde, Klemens, additional, Pratschke, Johann, additional, Klempnauer, Jürgen, additional, Zeier, Martin, additional, Arns, Wolfgang, additional, Hugo, Christian, additional, Rump, Lars-Christian, additional, Hauser, Ingeborg, additional, Schenker, Peter, additional, Schiffer, Mario, additional, Grimm, Marc-Oliver, additional, Kliem, Volker, additional, Olbricht, Christoph J., additional, Pisarski, Przemyslaw, additional, Banas, Bernhard, additional, Suwelack, Barbara, additional, Hakenberg, Oliver, additional, Berlakovich, Gabriela, additional, Schneeberger, Stefan, additional, van de Wetering, Jacqueline, additional, Berger, Stefan, additional, Bemelman, Frederike, additional, Kuypers, Dirk, additional, Heidt, Sebastiaan, additional, Rahmel, Axel, additional, Claas, Frans, additional, Peeters, Patrick, additional, Oberbauer, Rainer, additional, Heemann, Uwe, additional, Krämer, Bernhard K., additional, Tieken, I., additional, Haasnoot, G., additional, van Meel, M., additional, Rump, L.C., additional, Rosenkranz, A., additional, Horn, S., additional, Margreiter, R., additional, Schneeberger, S., additional, Oberbauer, R., additional, Pohanka, E., additional, Függer, F., additional, Mühlbacher, F., additional, Berlakovich, G., additional, Meurisse, M., additional, Weekers, L., additional, Ysebaert, D., additional, Wissing, K.M., additional, Mikhalski, D., additional, Mourad, M., additional, van Biesen, W., additional, Kuypers, D., additional, Floege, J., additional, Anthuber, M., additional, Viebahn, R., additional, Schenker, P., additional, Budde, K., additional, Pratschke, J., additional, Zidek, W., additional, Melchior, S., additional, Woitas, R., additional, Strassburg, C.H., additional, Hugo, C., additional, Wirth, M., additional, Schiffer, M., additional, Kribben, A., additional, Pisarski, P., additional, Fichtner-Feigl, S., additional, Haubitz, M., additional, Weimer, R., additional, Weithofer, P., additional, Fornara, P., additional, Fisher, L., additional, Sester, U., additional, Zeier, M., additional, Kliem, V., additional, Klempnauer, l, additional, Grimm, M.O., additional, Kunzendorf, U., additional, Stippel, D., additional, Arns, W., additional, Mönch, C., additional, Nitschke, M., additional, Bartels, M., additional, Krämer, B., additional, Kruger, B., additional, Heemann, U., additional, Werner, J., additional, Hoyer, J., additional, Wolters, H.H., additional, Suwelack, B., additional, Lutz, J., additional, Banas, B., additional, Hakenberg, O., additional, Olbricht, C.J., additional, Kalus, M., additional, Schwenger, V., additional, Nadalin, S., additional, Schröppel, B., additional, Lopau, K., additional, Seelen, M.A.J., additional, Berger, S.P., additional, de Fijter, J.W., additional, van der Linden, S.J., additional, Christiaans, M.H.L., additional, van de Wetering, J., additional, van Zuilen, A.D., additional, Bemelman, F., additional, Nurmohamed, A., additional, and Hilbrands, L., additional

Published
2023
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22. Kidney Transplantation after Rescue Allocation - The Eurotransplant Experience

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Mühlfeld, Anja, Bouts, Antonia, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Hüser, Norbert, Heemann, Uwe, Huüser, Norbert, Surgery, Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Paediatric Nephrology, ARD - Amsterdam Reproduction and Development, Interne Geneeskunde, MUMC+: MA Nefrologie (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, Pediatrics, Basic (bio-) Medical Sciences, and Diabetes Pathology & Therapy

Subjects
Waiting time, kidney, PREDICTOR, medicine.medical_specialty, Tissue and Organ Procurement, Eurotransplant, medicine.medical_treatment, Medizin, Outcome analysis, deceased donor renal transplantation, COLD ISCHEMIA TIME, surgery, All institutes and research themes of the Radboud University Medical Center, Internal medicine, DIALYSIS, Medicine and Health Sciences, Humans, Medicine, standard allocation, FRAILTY, Kidney transplantation, Dialysis, Retrospective Studies, RISK, GRAFT FAILURE, Transplantation, Deceased donor, rescue allocation, business.industry, MORTALITY, Incidence (epidemiology), Graft Survival, algorithms Eurotransplant kidney allocation system, ASSOCIATION, medicine.disease, Kidney Transplantation, Tissue Donors, Confidence interval, Eurotransplant senior program, RECIPIENTS, Treatment Outcome, SURVIVAL, Human medicine, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business
Abstract

BACKGROUND: At Eurotransplant (ET), kidneys are transferred to "rescue allocation" (RA), whenever the standard allocation (SA) algorithms Eurotransplant Kidney Allocation System (ETKAS) and Eurotransplant Senior Program (ESP) fail. We analyzed the outcome of RA. METHODS: Retrospective patient clinical and demographic characteristics association analyses were performed with graft outcomes for 2422 recipients of a deceased donor renal transplantation (DDRT) after RA versus 25 481 after SA from 71 centers across all ET countries from 2006 to 2018. RESULTS: Numbers of DDRTs after RA increased over the time, especially in Germany. RA played a minor role in ESP versus ETKAS (2.7% versus 10.4%). RA recipients and donors were older compared with SA recipients and donors, cold ischemia times were longer, waiting times were shorter, and the incidence of primary nonfunction was comparable. Among ETKAS recipients, HLA matching was more favorable in SA (mean 3.7 versus 2.5). In multivariate modeling, the incidence of graft loss in ETKAS recipients was reduced in RA compared with SA (subdistribution hazard ratio, 0.80; 95% confidence interval [0.70-0.91], P

Published
2022

23. Trends in kidney transplantation rate across Europe:a study from the ERA Registry

Author

Boenink, Rianne, Kramer, Anneke, Tuinhout, Rosalie E., Savoye, Emilie, Åsberg, Anders, Idrizi, Alma, Kerschbaum, Julia, Ziedina, Ieva, Ziginskiene, Edita, Farrugia, Emanuel, Garneata, Liliana, Zakharova, Elena V., Bell, Samira, Arnol, Miha, Segelmark, Mårten, Ioannou, Kyriakos, Hommel, Kristine, Rosenberg-Ots, Mai, Vazelov, Evgueniy, Helve, Jaakko, Mihály, Sándor, Pálsson, Runólfur, Nordio, Maurizio, Gjorgjievski, Nikola, De Vries, Aiko P. J., Seyahi, Nurhan, Magadi, Winnie A., Resić, Halima, Kalachyk, Aleh, Rahmel, Axel O., Galvão, Ana A., Naumovic, Radomir, Lundgren, Torbjörn, Arici, Mustafa, de Meester, Johan M., Ortiz, Alberto, Jager, Kitty J., Stel, Vianda S., Boenink, Rianne, Kramer, Anneke, Tuinhout, Rosalie E., Savoye, Emilie, Åsberg, Anders, Idrizi, Alma, Kerschbaum, Julia, Ziedina, Ieva, Ziginskiene, Edita, Farrugia, Emanuel, Garneata, Liliana, Zakharova, Elena V., Bell, Samira, Arnol, Miha, Segelmark, Mårten, Ioannou, Kyriakos, Hommel, Kristine, Rosenberg-Ots, Mai, Vazelov, Evgueniy, Helve, Jaakko, Mihály, Sándor, Pálsson, Runólfur, Nordio, Maurizio, Gjorgjievski, Nikola, De Vries, Aiko P. J., Seyahi, Nurhan, Magadi, Winnie A., Resić, Halima, Kalachyk, Aleh, Rahmel, Axel O., Galvão, Ana A., Naumovic, Radomir, Lundgren, Torbjörn, Arici, Mustafa, de Meester, Johan M., Ortiz, Alberto, Jager, Kitty J., and Stel, Vianda S.

Abstract

Background. The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. Methods. The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. Results. The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East-West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.). Conclusions. The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries.

Published
2023

24. A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program

Author

de Fijter, Johan, Dreyer, Geertje, Mallat, Marko, Budde, Klemens, Pratschke, Johann, Klempnauer, Jürgen, Zeier, Martin, Arns, Wolfgang, Hugo, Christian, Rump, L. C., Hauser, Ingeborg, Schenker, Peter, Schiffer, Mario, Grimm, Marc Oliver, Kliem, Volker, Olbricht, Christoph J., Pisarski, Przemyslaw, Banas, Bernhard, Suwelack, Barbara, Hakenberg, Oliver, Berlakovich, G., Schneeberger, S., van de Wetering, Jacqueline, Berger, S. P., Bemelman, Frederike, Kuypers, Dirk, Heidt, Sebastiaan, Rahmel, Axel, Claas, Frans, Peeters, Patrick, Oberbauer, R., Heemann, Uwe, Krämer, Bernhard, Tieken, I., Haasnoot, G., Bartels, M., Lutz, J., van der Linden, S. J., de Fijter, Johan, Dreyer, Geertje, Mallat, Marko, Budde, Klemens, Pratschke, Johann, Klempnauer, Jürgen, Zeier, Martin, Arns, Wolfgang, Hugo, Christian, Rump, L. C., Hauser, Ingeborg, Schenker, Peter, Schiffer, Mario, Grimm, Marc Oliver, Kliem, Volker, Olbricht, Christoph J., Pisarski, Przemyslaw, Banas, Bernhard, Suwelack, Barbara, Hakenberg, Oliver, Berlakovich, G., Schneeberger, S., van de Wetering, Jacqueline, Berger, S. P., Bemelman, Frederike, Kuypers, Dirk, Heidt, Sebastiaan, Rahmel, Axel, Claas, Frans, Peeters, Patrick, Oberbauer, R., Heemann, Uwe, Krämer, Bernhard, Tieken, I., Haasnoot, G., Bartels, M., Lutz, J., and van der Linden, S. J.

Abstract

The Eurotransplant Senior Program (ESP) has expedited the chance for elderly patients with kidney failure to receive a timely transplant. This current study evaluated survival parameters of kidneys donated after brain death with or without matching for HLA-DR antigens. This cohort study evaluated the period within ESP with paired allocation of 675 kidneys from donors 65 years and older to transplant candidates 65 years and older, the first kidney to 341 patients within the Eurotransplant Senior DR-compatible Program and 334 contralateral kidneys without (ESP) HLA-DR antigen matching. We used Kaplan-Meier estimates and competing risk analysis to assess all cause mortality and kidney graft failure, respectively. The log-rank test and Cox proportional hazards regression were used for comparisons. Within ESP, matching for HLA-DR antigens was associated with a significantly lower five-year risk of mortality (hazard ratio 0.71; 95% confidence interval 0.53-0.95) and significantly lower cause-specific hazards for kidney graft failure and return to dialysis at one year (0.55; 0.35-0.87) and five years (0.73; 0.53-0.99) post-transplant. Allocation based on HLA-DR matching resulted in longer cold ischemia (mean difference 1.00 hours; 95% confidence interval: 0.32-1.68) and kidney offers with a significantly shorter median dialysis vintage of 2.4 versus 4.1 yrs. in ESP without matching. Thus, our allocation based on HLA-DR matching improved five-year patient and kidney allograft survival. Hence, our paired allocation study suggests a superior outcome of HLA-DR matching in the context of old-for-old kidney transplantation.

Published
2023

25. Trends in kidney transplantation rate across Europe: study from the ERA Registry

Author

Boenink, Rianne, primary, Kramer, Anneke, additional, Tuinhout, Rosalie E, additional, Savoye, Emilie, additional, Åsberg, Anders, additional, Idrizi, Alma, additional, Kerschbaum, Julia, additional, Ziedina, Ieva, additional, Ziginskiene, Edita, additional, Farrugia, Emanuel, additional, Garneata, Liliana, additional, Zakharova, Elena V, additional, Bell, Samira, additional, Arnol, Miha, additional, Segelmark, Mårten, additional, Ioannou, Kyriakos, additional, Hommel, Kristine, additional, Rosenberg-Ots, Mai, additional, Vazelov, Evgueniy, additional, Helve, Jaakko, additional, Mihály, Sándor, additional, Pálsson, Runólfur, additional, Nordio, Maurizio, additional, Gjorgjievski, Nikola, additional, de Vries, Aiko P J, additional, Seyahi, Nurhan, additional, Magadi, Winnie A, additional, Resić, Halima, additional, Kalachyk, Aleh, additional, Rahmel, Axel O, additional, Galvão, Ana A, additional, Naumovic, Radomir, additional, Lundgren, Torbjörn, additional, Arici, Mustafa, additional, de Meester, Johan M, additional, Ortiz, Alberto, additional, Jager, Kitty J, additional, and Stel, Vianda S, additional

Published
2023
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26. The Reality of Inadequate Patient Care and the Need for a Global Action Framework in Organ Donation and Transplantation

Author

Domínguez-Gil, Beatriz, primary, Ascher, Nancy L., additional, Fadhil, Riadh A.S., additional, Muller, Elmi, additional, Cantarovich, Marcelo, additional, Ahn, Curie, additional, Berenguer, Marina, additional, Bušić, Mirela, additional, Egawa, Hiroto, additional, Gondolesi, Gabriel E., additional, Haberal, Mehmet, additional, Harris, David, additional, Hirose, Ryutaro, additional, Ilbawi, André, additional, Jha, Vivekanand, additional, López-Fraga, Marta, additional, Andrés Madera, Sergio, additional, Najafizadeh, Katayoun, additional, O’Connell, Philip J., additional, Rahmel, Axel, additional, Shaheen, Faissal A.M., additional, Twahir, Ahmed, additional, Van Assche, Kristof, additional, Wang, Haibo, additional, Haraldsson, Boerje, additional, Chatzixiros, Efstratios, additional, and Delmonico, Francis L., additional

Published
2022
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36. Kidney Transplantation After Rescue Allocation-the Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Muehlfeld, Anja, Bouts, Antonia, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, Laszlo, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Fuegger, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krueger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Hueser, Norbert, Heemann, Uwe, Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Muehlfeld, Anja, Bouts, Antonia, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, Laszlo, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Fuegger, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krueger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Hueser, Norbert, and Heemann, Uwe

Abstract

Background. At Eurotransplant (ET), kidneys are transferred to rescue allocation (RA), whenever the standard allocation (SA) algorithms Eurotransplant Kidney Allocation System (ETKAS) and Eurotransplant Senior Program (ESP) fail. We analyzed the outcome of RA. Methods. Retrospective patient clinical and demographic characteristics association analyses were performed with graft outcomes for 2422 recipients of a deceased donor renal transplantation (DDRT) after RA versus 25 481 after SA from 71 centers across all ET countries from 2006 to 2018. Results. Numbers of DDRTs after RA increased over the time, especially in Germany. RA played a minor role in ESP versus ETKAS (2.7% versus 10.4%). RA recipients and donors were older compared with SA recipients and donors, cold ischemia times were longer, waiting times were shorter, and the incidence of primary nonfunction was comparable. Among ETKAS recipients, HLA matching was more favorable in SA (mean 3.7 versus 2.5). In multivariate modeling, the incidence of graft loss in ETKAS recipients was reduced in RA compared with SA (subdistribution hazard ratio, 0.80; 95% confidence interval [0.70-0.91], P < 0.001), whereas other outcomes (mortality, death with functioning graft (DwFG)) were not significantly different. None of the 3 outcomes were significantly different when comparing RA with SA within the ESP program. Conclusions. Facing increased waiting times and mortality on dialysis due to donor shortage, this study reveals encouragingly positive DDRT outcomes following RA. This supports the extension of RA to more patients and as an alternative tool to enable transplantation in patients in countries with prohibitively long waiting times or at risk of deterioration.

Published
2022

37. Kidney Transplantation after Rescue Allocation - The Eurotransplant Experience:A Retrospective Multicenter Outcome Analysis

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, Van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Mühlfeld, Anja, Bouts, Antonia, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, Van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, Van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Huser, Norbert, Heemann, Uwe, Assfalg, Volker, Miller, Gregor, Stocker, Felix, Van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Mühlfeld, Anja, Bouts, Antonia, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, Van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, Van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Huser, Norbert, and Heemann, Uwe

Abstract

Background. At Eurotransplant (ET), kidneys are transferred to "rescue allocation" (RA), whenever the standard allocation (SA) algorithms Eurotransplant Kidney Allocation System (ETKAS) and Eurotransplant Senior Program (ESP) fail. We analyzed the outcome of RA. Methods. Retrospective patient clinical and demographic characteristics association analyses were performed with graft outcomes for 2422 recipients of a deceased donor renal transplantation (DDRT) after RA versus 25 481 after SA from 71 centers across all ET countries from 2006 to 2018. Results. Numbers of DDRTs after RA increased over the time, especially in Germany. RA played a minor role in ESP versus ETKAS (2.7% versus 10.4%). RA recipients and donors were older compared with SA recipients and donors, cold ischemia times were longer, waiting times were shorter, and the incidence of primary nonfunction was comparable. Among ETKAS recipients, HLA matching was more favorable in SA (mean 3.7 versus 2.5). In multivariate modeling, the incidence of graft loss in ETKAS recipients was reduced in RA compared with SA (subdistribution hazard ratio, 0.80; 95% confidence interval [0.70-0.91], P < 0.001), whereas other outcomes (mortality, death with functioning graft (DwFG)) were not significantly different. None of the 3 outcomes were significantly different when comparing RA with SA within the ESP program. Conclusions. Facing increased waiting times and mortality on dialysis due to donor shortage, this study reveals encouragingly positive DDRT outcomes following RA. This supports the extension of RA to more patients and as an alternative tool to enable transplantation in patients in countries with prohibitively long waiting times or at risk of deterioration.

Published
2022

38. Kidney Transplantation after Rescue Allocation - the Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis

Author

MS Nefrologie, Circulatory Health, Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Muehlfeld, Anja, Antonia, Bouts, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R, Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Huüser, Norbert, Heemann, Uwe, MS Nefrologie, Circulatory Health, Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Muehlfeld, Anja, Antonia, Bouts, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R, Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Huüser, Norbert, and Heemann, Uwe

Published
2022

41. Postmortale Organspende bei seltenen Erkrankungen - Kasuistiken und Algorithmus

Author

Doede, Thorsten, Fischer-Fröhlich, Carl-Ludwig, Bösebeck, Detlef, and Rahmel, Axel

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Die Mehrzahl der Organspender weisen SHT oder kardiovaskuläre Grunderkrankungen auf. Zuweilen liegt aber auch “seltene Erkrankungen” vor oder sind zumindest Komorbidität. Dieses soll kasuistisch dargestellt werden inkl. der grundsätzlichen Algorithmen. Methods:[zum vollständigen Text gelangen Sie über die oben angegebene URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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43. Effects of donor pretreatment with Dopamine on graft function after kidney transplant

Author

Schnuelle, Peter, Gottmann, Uwe, Hoeger, Simone, Boesebeck, Detlef, Lauchart, Werner, Weiss, Christel, Fischereder, Michael, Jauch, Karl-Walter, Heemann, Uwe, Zeier, Martin, Hugo, Christian, Pisarski, Przemyslaw, Kramer, Bernhard K., Lopau, Kai, Rahmel, Axel, Benck, Urs, Birck, Rainer, and Yard, Benito Antonio

Subjects
Company business management, Hemodialysis -- Usage, Organ donors -- Health aspects, Dopamine -- Health aspects, Dopamine -- Usage, Kidneys -- Transplantation, Kidneys -- Management
Abstract

The study aims to evaluate the efficacy of pretreatment of brain-dead donors with Dopamine on graft function after kidney transplant. The results indicate that such pretreatment is effective in reducing the need for dialysis after kidney transplantation.

Published
2009

44. Machine perfusion or cold storage in deceased-donor kidney transplantation

Author

Moers, Cyril, Smits, Jacqueline M., Maathuis, Mark-Hugo J., Treckmann, Jurgen, van Gelder, Frank, Napieralski, Bogdan P., van der Heide, Jaap J. Homan, Van Kasterop-Kutz, Margitta, Squifflet, Jean-Paul, van Heurn, Ernest, Kirste, Gunter R., Rahmel, Axel, Leuvenink, Henri G.D., Paul, Andreas, Pirenne, Jacques, and Ploeg, Rutger J.

Subjects
Homografts -- Usage, Homografts -- Health aspects, Preservation of organs, tissues, etc. -- Methods, Kidneys -- Transplantation, Kidneys -- Health aspects
Abstract

A study was conducted to evaluate whether hypothermic machine perfusion or cold storage of kidney allografts from deceased donors helps reduce risk of delayed graft function and increases graft survival after kidney transplantation. Results confirmed that hypothermic machine perfusion reduces risk and affords a better rate of survival for transplantation patients in the first year after transplantation.

Published
2009

47. Repeated kidney re-transplantation-the Eurotransplant experience: a retrospective multicenter outcome analysis

Author

Assfalg, Volker, Selig, Katharina, Tolksdorf, Johanna, van Meel, Marieke, de Vries, Erwin, Ramsoebhag, Anne-Marie, Rahmel, Axel, Renders, Lutz, Novotny, Alexander, Matevossian, Edouard, Schneeberger, Stefan, Rosenkranz, Alexander R., Berlakovich, Gabriela, Ysebaert, Dirk, Knops, Noel, Kuypers, Dirk, Weekers, Laurent, Muehlfeld, Anja, Rump, Lars-Christian, Hauser, Ingeborg, Pisarski, Przemyslaw, Weimer, Rolf, Fornara, Paolo, Fischer, Lutz, Kliem, Volker, Sester, Urban, Stippel, Dirk, Arns, Wolfgang, Hau, Hans-Michael, Nitschke, Martin, Hoyer, Joachim, Thorban, Stefan, Weinmann-Menke, Julia, Heller, Katharina, Banas, Bernhard, Schwenger, Vedat, Nadalin, Silvio, Lopau, Kai, Hueser, Norbert, Heemann, Uwe, Assfalg, Volker, Selig, Katharina, Tolksdorf, Johanna, van Meel, Marieke, de Vries, Erwin, Ramsoebhag, Anne-Marie, Rahmel, Axel, Renders, Lutz, Novotny, Alexander, Matevossian, Edouard, Schneeberger, Stefan, Rosenkranz, Alexander R., Berlakovich, Gabriela, Ysebaert, Dirk, Knops, Noel, Kuypers, Dirk, Weekers, Laurent, Muehlfeld, Anja, Rump, Lars-Christian, Hauser, Ingeborg, Pisarski, Przemyslaw, Weimer, Rolf, Fornara, Paolo, Fischer, Lutz, Kliem, Volker, Sester, Urban, Stippel, Dirk, Arns, Wolfgang, Hau, Hans-Michael, Nitschke, Martin, Hoyer, Joachim, Thorban, Stefan, Weinmann-Menke, Julia, Heller, Katharina, Banas, Bernhard, Schwenger, Vedat, Nadalin, Silvio, Lopau, Kai, Hueser, Norbert, and Heemann, Uwe

Abstract

In Eurotransplant kidney allocation system (ETKAS), candidates can be considered unlimitedly for repeated re-transplantation. Data on outcome and benefit are indeterminate. We performed a retrospective 15-year patient and graft outcome data analysis from 1464 recipients of a third or fourth or higher sequential deceased donor renal transplantation (DDRT) from 42 transplant centers. Repeated re-DDRT recipients were younger (mean 43.0 vs. 50.2 years) compared to first DDRT recipients. They received grafts with more favorable HLA matches (89.0% vs. 84.5%) but thereby no statistically significant improvement of patient and graft outcome was found as comparatively demonstrated in 1st DDRT. In the multivariate modeling accounting for confounding factors, mortality and graft loss after 3rd and >= 4th DDRT (P < 0.001 each) and death with functioning graft (DwFG) after 3rd DDRT (P = 0.001) were higher as compared to 1st DDRT. The incidence of primary nonfunction (PNF) was also significantly higher in re-DDRT (12.7%) than in 1st DDRT (7.1%; P < 0.001). Facing organ shortage, increasing waiting time, and considerable mortality on dialysis, we question the current policy of repeated re-DDRT. The data from this survey propose better HLA matching in first DDRT and second DDRT and careful selection of candidates, especially for >= 4th DDRT.

Published
2020

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