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1. First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis

Author

Kasenda, B., Ferreri, A. J. M., Marturano, E., Forst, D., Bromberg, J., Ghesquieres, H., Ferlay, C., Blay, J. Y., Hoang-Xuan, K., Pulczynski, E. J., Fosså, A., Okoshi, Y., Chiba, S., Fritsch, K., Omuro, A., OʼNeill, B. P., Bairey, O., Schandelmaier, S., Gloy, V., Bhatnagar, N., Haug, S., Rahner, S., Batchelor, T. T., Illerhaus, G., and Briel, M.

Published
2015
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4. Offen chirurgisch organerhaltende Nierentumorexzision in regionaler Ischämie – erste Erfahrungen mit der Anwendung einer neuartigen Klemme

Author

Rahner, S, Simon, J, and Groh, R

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Techniken zum Ausklemmen des tumortragenden Parenchymanteils stellen eine attraktive Option bei der organerhaltenden Nierentumorexzision dar. In dieser Arbeit untersuchten wir eine speziell für diesen Einsatz entwickelte Klemme (Klemme n. Simon, EF 0173, Aesculap AG, Tuttlingen, Deutschland)[zum vollständigen Text gelangen Sie über die oben angegebene URL], 59. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V. - Urologie im Südwesten: Innovation aus Tradition

Published
2018
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6. First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis

Author

Kasenda, B., Ferreri, A. J. M., Marturano, E., Forst, D., Bromberg, J., Ghesquieres, H., Ferlay, C., Blay, J. Y., Hoang-Xuan, K., Pulczynski, E. J., Fosså, A., Okoshi, Y., Chiba, S., Fritsch, K., Omuro, A., O'Neill, B. P., Bairey, O., Schandelmaier, S., Gloy, V., Bhatnagar, N., Haug, S., Rahner, S., Batchelor, T. T., Illerhaus, G., Briel, M., Kasenda, B., Ferreri, A. J. M., Marturano, E., Forst, D., Bromberg, J., Ghesquieres, H., Ferlay, C., Blay, J. Y., Hoang-Xuan, K., Pulczynski, E. J., Fosså, A., Okoshi, Y., Chiba, S., Fritsch, K., Omuro, A., O'Neill, B. P., Bairey, O., Schandelmaier, S., Gloy, V., Bhatnagar, N., Haug, S., Rahner, S., Batchelor, T. T., Illerhaus, G., and Briel, M.

Abstract

Evidence for prognosis and treatment of elderly patient with primary central nervous system is limited. High-dose methotrexate should be applied whenever possible, especially combination with oral alkylating agents is a promising approach. Further combinations with other intravenous drugs do not seem to improve outcome. More prospective trials designed for elderly PCNSL patients are warranted

Published
2017

7. First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)-a systematic review and individual patient data meta-analysis

Author

Kasenda, B. (Benjamin), Ferreri, A.J.M. (Andrés J.M.), Marturano, E., Forst, D., Bromberg, J.E.C. (Jacoline), Ghesquieres, H., Ferlay, C., Blay, J.Y. (Jean Yves), Hoang-Xuan, K. (Khê), Pulczynski, E.J., Fosså, A., Okoshi, Y., Chiba, S. (Shigeru), Fritsch, K. (Kristina), Omuro, A., O'Neill, B.P., Bairey, O., Schandelmaier, S., Gloy, V., Bhatnagar, N., Haug, S., Rahner, S., Batchelor, T.T. (Tracy), Illerhaus, G. (Gerald), Brie, M., Kasenda, B. (Benjamin), Ferreri, A.J.M. (Andrés J.M.), Marturano, E., Forst, D., Bromberg, J.E.C. (Jacoline), Ghesquieres, H., Ferlay, C., Blay, J.Y. (Jean Yves), Hoang-Xuan, K. (Khê), Pulczynski, E.J., Fosså, A., Okoshi, Y., Chiba, S. (Shigeru), Fritsch, K. (Kristina), Omuro, A., O'Neill, B.P., Bairey, O., Schandelmaier, S., Gloy, V., Bhatnagar, N., Haug, S., Rahner, S., Batchelor, T.T. (Tracy), Illerhaus, G. (Gerald), and Brie, M.

Abstract

Background: To investigate prognosis and effects of first-line therapy in elderly primary central nervous system lymphoma (PCNSL) patients. Patients and methods: A systematic review of studies about first-line therapy in immunocompetent patients ≥60 years with PCNSL until 2014 and a meta-analysis of individual patient data from eligible studies and international collaborators were carried out. Results: We identified 20 eligible studies; from 13

Published
2015
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10. Hydrothermal alteration and precipitation processes on Methana peninsula, Greece.

Author

Rahders E., The fourth biennial SGA meeting Turku, Finland 11-Aug-9713-Aug-97, Halbach M., Halbach P., Rahner S., Varnavas S.P., Rahders E., The fourth biennial SGA meeting Turku, Finland 11-Aug-9713-Aug-97, Halbach M., Halbach P., Rahner S., and Varnavas S.P.

Abstract

Two different hydrothermal mineralisation types (carbonate precipitation and alunitisation) were studied from the Methana peninsula, which is on the western end of the Hellenic volcanic arc. These sub-recent to recent hydrothermal activities were mostly related to NW-SW striking normal faults. Low temperature solutions have altered dacitic-rhyodacitic volcanic rocks in vein type calcite mineralisations or in larger zones containing amorphous silica, alunogen, kaolinite, gypsum, anhydrite and sulphur. With the exception of Fe, Mn, Zn and Ni, other base metals are not enriched. Apart from tectonics, the major controlling factor for these two alteration types was the mixing of hydrothermal with seawater., Two different hydrothermal mineralisation types (carbonate precipitation and alunitisation) were studied from the Methana peninsula, which is on the western end of the Hellenic volcanic arc. These sub-recent to recent hydrothermal activities were mostly related to NW-SW striking normal faults. Low temperature solutions have altered dacitic-rhyodacitic volcanic rocks in vein type calcite mineralisations or in larger zones containing amorphous silica, alunogen, kaolinite, gypsum, anhydrite and sulphur. With the exception of Fe, Mn, Zn and Ni, other base metals are not enriched. Apart from tectonics, the major controlling factor for these two alteration types was the mixing of hydrothermal with seawater.

Published
1997

15. Scavenging effects of Fe-hydroxide coated sand in phreatic aquifers.

Author

Rahner S., Amiel A.J., Magaritz M., Rahner S., Amiel A.J., and Magaritz M.

Abstract

Sand grains coated with Fe-hydroxide were compared with uncoated sand grains as an adsorbant filtration media for the treatment of metal-bearing waters. Coated and uncoated sand grains were placed into dialysis cells of a multilayer sampler and then placed into a research well. After two months of exposure, the samples were retrieved and analysed for Cr, Pb, Ni, Cd, Mn and Co concentrations. Transmitted light and scanning electron light microscopy showed that the coating prevailed in the field and was not removed. Only Cr showed significant enrichment on the coated material compared to the uncoated material, indicating that the exposure of the Fe-coated surface to groundwater was sufficient for preferential scavenging of Cr from the water. The eight-fold enrichment of Cr may be related to its oxidation state of +3, thereby readily permitting substitution into the Fe3+ position in the coating material. The rest of the studied metals were only slightly enriched in the coated grain., Sand grains coated with Fe-hydroxide were compared with uncoated sand grains as an adsorbant filtration media for the treatment of metal-bearing waters. Coated and uncoated sand grains were placed into dialysis cells of a multilayer sampler and then placed into a research well. After two months of exposure, the samples were retrieved and analysed for Cr, Pb, Ni, Cd, Mn and Co concentrations. Transmitted light and scanning electron light microscopy showed that the coating prevailed in the field and was not removed. Only Cr showed significant enrichment on the coated material compared to the uncoated material, indicating that the exposure of the Fe-coated surface to groundwater was sufficient for preferential scavenging of Cr from the water. The eight-fold enrichment of Cr may be related to its oxidation state of +3, thereby readily permitting substitution into the Fe3+ position in the coating material. The rest of the studied metals were only slightly enriched in the coated grain.

16. First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis

Author

Kasenda, B., Ferreri, A. J. M., Marturano, E., Forst, D., Bromberg, J., Ghesquieres, H., Ferlay, C., Blay, J. Y., Hoang-Xuan, K., Pulczynski, E. J., Fosså, A., Okoshi, Y., Chiba, S., Fritsch, K., Omuro, A., O'Neill, B. P., Bairey, O., Schandelmaier, S., Gloy, V., Bhatnagar, N., Haug, S., Rahner, S., Batchelor, T. T., Illerhaus, G., Briel, M., Kasenda, B., Ferreri, A. J. M., Marturano, E., Forst, D., Bromberg, J., Ghesquieres, H., Ferlay, C., Blay, J. Y., Hoang-Xuan, K., Pulczynski, E. J., Fosså, A., Okoshi, Y., Chiba, S., Fritsch, K., Omuro, A., O'Neill, B. P., Bairey, O., Schandelmaier, S., Gloy, V., Bhatnagar, N., Haug, S., Rahner, S., Batchelor, T. T., Illerhaus, G., and Briel, M.

Abstract

Evidence for prognosis and treatment of elderly patient with primary central nervous system is limited. High-dose methotrexate should be applied whenever possible, especially combination with oral alkylating agents is a promising approach. Further combinations with other intravenous drugs do not seem to improve outcome. More prospective trials designed for elderly PCNSL patients are warranted

17. Fibroblast growth factor signaling pathway in endothelial cells is activated by BMPER to promote angiogenesis.

Author

Esser JS, Rahner S, Deckler M, Bode C, Patterson C, and Moser M

Subjects
Animals, Apoptosis, Carrier Proteins genetics, Carrier Proteins pharmacology, Cells, Cultured, Dose-Response Relationship, Drug, Endothelial Cells drug effects, Female, Fibroblast Growth Factor 2 genetics, Fibroblast Growth Factor 2 pharmacology, Human Umbilical Vein Endothelial Cells metabolism, Humans, Mice, Inbred C57BL, Mice, Knockout, Phosphorylation, Protein Array Analysis, Proteomics methods, RNA Interference, Receptor, Fibroblast Growth Factor, Type 1 genetics, Receptor, Fibroblast Growth Factor, Type 1 metabolism, Recombinant Proteins pharmacology, Signal Transduction, Thrombospondin 1 metabolism, Tissue Culture Techniques, Transfection, Carrier Proteins metabolism, Endothelial Cells metabolism, Fibroblast Growth Factor 2 metabolism, Neovascularization, Physiologic drug effects
Abstract

Objective: Previously, we have identified bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER) to increase the angiogenic activity of endothelial cells in a concentration-dependent manner. In this project, we now investigate how BMPER acts in concert with key molecules of angiogenesis to promote blood vessel formation., Approach and Results: To assess the effect of BMPER on angiogenesis-related signaling pathways, we performed an angiogenesis antibody array with BMPER-stimulated endothelial cells. We detected increased basic fibroblast growth factor (bFGF/FGF-2) expression after BMPER stimulation and decreased expression of thrombospondin-1. Additionally, FGF receptor-1 expression, phosphorylation, FGF signaling pathway activity, and cell survival were increased. Consistently, silencing of BMPER by small interfering RNA decreased bFGF and FGF receptor-1 expression and increased thrombospondin-1 expression and cell apoptosis. Next, we investigated the interaction of BMPER and the FGF signaling pathway in endothelial cell function. BMPER stimulation increased endothelial cell angiogenic activity in migration, Matrigel, and spheroid assays. To block FGF signaling, an anti-bFGF antibody was used, which effectively inhibited the proangiogenic BMPER effect. Accordingly, BMPER-silenced endothelial cells under bFGF stimulation showed decreased angiogenic activity compared with bFGF control. We confirmed these findings in vivo by subcutaneous Matrigel injections with and without bFGF in C57BL/6_Bmper(+/-) mice. Aortic ring assays of C57BL/6_Bmper(+/-) mice confirmed a specific effect for bFGF but not for vascular endothelial growth factor., Conclusions: Taken together, the proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis., (© 2014 American Heart Association, Inc.)

Published
2015
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18. Expression of CD44, ICAM-1 and N-CAM in colorectal cancer. Correlation with the tumor stage and the phenotypical characteristics of tumor-infiltrating lymphocytes.

Author

Wimmenauer S, Keller H, Rückauer KD, Rahner S, Wolff-Vorbeck G, Kirste G, von Kleist S, and Farthman EH

Subjects
Adenocarcinoma immunology, Adenocarcinoma pathology, Adult, Aged, Colorectal Neoplasms immunology, Colorectal Neoplasms pathology, Female, Humans, Immunoenzyme Techniques, Immunophenotyping, Lymphocytes, Tumor-Infiltrating pathology, Male, Middle Aged, Neoplasm Metastasis, Adenocarcinoma metabolism, Colorectal Neoplasms metabolism, Hyaluronan Receptors metabolism, Intercellular Adhesion Molecule-1 metabolism, Neural Cell Adhesion Molecules metabolism
Abstract

The cellular adhesion molecules (CAMs) CD44s, CD44v6, CD44v10, ICAM-1 and N-CAM were immunohistologically detected in colorectal cancers using the APAAP method. The expression of CD44s and CD44v6 was associated with the presence of lymph node metastases in the examined tumors. The pattern of ICAM-1 expression was inversely related to that of CD44, i.e. lower numbers of ICAM-1 positive cells were observed in metastasizing tumors. An intense focal staining of N-CAM was observed in the majority of the metastasizing tumors. The expression of CD44v, ICAM-1 or N-CAM on tumor cells did not correlate with the density of the tumor-infiltrating lymphocytes (TIL) within the tumors. The flowcytometric analysis of TIL showed a significant accumulation of CD25+ and HLA-DR+ cells and a reduced number of CD45RA+ cells as compared to autologous peripheral blood lymphocytes (PBL) or intraepithelial lymphocytes of the colon mucosa (IEL). These phenotypic characteristics of TIL did not correlate with the CAMexpression on tumor cells.

Published
1997

19. Phenotypical and functional differences of tumor-infiltrating lymphocytes from human colorectal cancers induced by costimulation with rIL-2 and rIL-4 in vitro.

Author

Keller H, Wimmenauer S, Rahner S, Von Kleist S, and Farthmann EH

Subjects
Adult, Aged, Cell Division, Female, Humans, Lymphocyte Subsets cytology, Lymphocyte Subsets drug effects, Lymphocyte Subsets physiology, Lymphocytes, Tumor-Infiltrating cytology, Lymphocytes, Tumor-Infiltrating physiology, Male, Middle Aged, Phenotype, Recombinant Proteins pharmacology, T-Lymphocytes, Cytotoxic physiology, Colorectal Neoplasms immunology, Interleukin-2 pharmacology, Interleukin-4 pharmacology, Lymphocytes, Tumor-Infiltrating drug effects
Abstract

The influence of recombinant human interleukin-4 (rIL-4) on the proliferation and cytotoxic activity of tumor-infiltrating lymphocytes (TIL) from human colorectal cancers was investigated TIL and peripheral blood lymphocytes (PBL) were cultured for 3-5 weeks. Under simultaneous stimulation with rIL-2 and rIL-4 the proliferation of TIL was less pronounced compared to stimulation with rIL-2 alone. In rIL-2 expanded TIL an outgrowth of CD56+ cells was observed. Concordantly, the expression of CD3+ cells was low. The number of CD56+ cells could be reduced significantly in TIL and PBL by stimulation with rIL-2 and rIL-4 simultaneously while the number of CD3+ cells increased. In TIL and PBL co-stimulation with rIL2 and rIL-4 resulted in higher CD4/CD8 ratios as compared to expansion with rIL-2 alone. In a 72 hour cytotoxicity assay the rIL-2/rIL-4 expanded TIL and PBL showed a lower lytic activity against autologous tumor targets in comparison to the rIL-2 expanded lymphocytes. In contrast, the cytotoxic activity of rIL-2/rIL-4 cultured TIL against allogeneic tumor cells was higher than in rIL-2 stimulated TIL.

Published
1996

20. Phenotypical and functional characteristics of tumor-infiltrating lymphocytes from colon carcinomas stimulated with rIL-2 and rIL-4 in vitro: comparison with lymphocytes of the normal colon mucosa and the peripheral blood.

Author

Wimmenauer S, Keller H, Rahner S, Kirste G, von Bergwelt-Baildon M, Meyer A, Von Kleist S, and Farthmann EH

Subjects
Adult, Aged, Aged, 80 and over, Cytotoxicity, Immunologic, Female, Humans, Immunophenotyping, Intestinal Mucosa immunology, Male, Middle Aged, Recombinant Proteins pharmacology, Colon immunology, Colonic Neoplasms immunology, Interleukin-2 pharmacology, Interleukin-4 pharmacology, Lymphocyte Activation drug effects, Lymphocytes, Tumor-Infiltrating immunology
Abstract

The phenotypical composition of tumor-infiltrating lymphocytes (TIL) from colorectal carcinomas was compared with that of intraepithelial lymphocytes of the autologous normal colon mucosa (IEL) and autologous peripheral blood lymphocytes (PBL). The CD4+/CD8+ ratios of the freshly isolated TIL, IEL and PBL were comparable and always > 1. CD25+, HLA-DR+ and CD56+ cells accumulated significantly in the TIL, while CD45RA+ cells were less frequent compared to the autologous IEL and PBL. CD29+ memory-cells were found with the highest frequency in the TIL. Stimulation with rIL-2 in vitro induced an outgrowth of CD56+ cells in the TIL. Concordantly the expression of CD3+ and the alpha/beta T-cell receptor was low. In a standard 51Cr-release assay these phenotypically LAK-cells representing effectors displayed an unspecific lytic activity against the autologous tumor as well as against allogeneic K562 and Daudi targets. The number of CD56+ cells could be reduced in TIL and PBL by simultaneous stimulation with rIL-2 and rIL-4, while the number of CD3+ cells increased.

Published
1994

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