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33 results on '"Rasinger, Josef D."'

3. Crude oil exposure of early life stages of Atlantic haddock suggests threshold levels for developmental toxicity as low as 0.1 μg total polyaromatic hydrocarbon (TPAH)/L

Author

Sørhus, Elin, Sørensen, Lisbet, Grøsvik, Bjørn Einar, Le Goff, Jérémie, Incardona, John P., Linbo, Tiffany L., Baldwin, David H., Karlsen, Ørjan, Nordtug, Trond, Hansen, Bjørn Henrik, Thorsen, Anders, Donald, Carey E., van der Meeren, Terje, Robson, William, Rowland, Steven J., Rasinger, Josef D., Vikebø, Frode B., and Meier, Sonnich

Published
2023
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13. Comparing novel shotgun DNA sequencing and state-of-the-art proteomics approaches for authentication of fish species in mixed samples

Author

Varunjikar, Madhushri S., primary, Moreno-Ibarguen, Carlos, additional, Andrade-Martinez, Juan S., additional, Tung, Hui-Shan, additional, Belghit, Ikram, additional, Palmblad, Magnus, additional, Olsvik, Pål A., additional, Reyes, Alejandro, additional, Rasinger, Josef D., additional, and Lie, Kai K., additional

Published
2022
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20. Factors influencing risk assessments of brominated flame-retardants:evidence based on seafood from the North East Atlantic Ocean

Author

Nostbakken, Ole Jakob, Duinker, Arne, Rasinger, Josef D., Nilsen, Bente M., Sanden, Monica, Frantzen, Sylvia, Hove, Helge T., Lundebye, Anne-Katrine, Berntssen, Marc H. G., Hannisdal, Rita, Madsen, Lise, Maage, Amund, Nostbakken, Ole Jakob, Duinker, Arne, Rasinger, Josef D., Nilsen, Bente M., Sanden, Monica, Frantzen, Sylvia, Hove, Helge T., Lundebye, Anne-Katrine, Berntssen, Marc H. G., Hannisdal, Rita, Madsen, Lise, and Maage, Amund

Published
2018

21. A study of selenoproteins in atlantic salmon (Salmo salar) using hyphenated mass spectrometry and bioinformatics

Author

Sele, Veronika, Perez, Magali, Raab, Andrea, Mariotti, Marco, Krupp, Eva, Feldmann, Joerg, Sloth, Jens Jørgen, Ørnsrud, Robin, Berntssen, Marc H. G., Rasinger, Josef D., Sele, Veronika, Perez, Magali, Raab, Andrea, Mariotti, Marco, Krupp, Eva, Feldmann, Joerg, Sloth, Jens Jørgen, Ørnsrud, Robin, Berntssen, Marc H. G., and Rasinger, Josef D.

Abstract

Selenium (Se) is an essential micronutrient for vertebrates and fish. Se is central to the function of selenoproteins, which play key roles in many biological functions including redox signaling, antioxidant defense, hormone metabolism, and immune responses. The number and expression levels of selenoproteins vary between different animal species with teleost fish featuring a much higher number of selenoproteins compared to vertebrates. While selenoproteomes have been well described for many species, a comprehensive analysis of selenoproteins in Atlantic salmon (Salmo salar) has yet to be performed. With recent advances in bioinformatics it has become possible to predict selenoproteins using computational tools; however, these in silico predictions description require validation through analytical data. In the present study we applied gel electrophoresis with subsequent use of laser ablation coupled to inductively coupled plasma mass spectrometry (LA-ICP-MS), and tryptic digestion with subsequent analysis with high performance liquid chromatography (HPLC) coupled to both ICPMS and high-resolution tandem electrospray mass spectrometry (HR-ESI-MS) for the analysis of selenooproteins. Furthermore, we set out to combine theoretical selenoprotein predictions with hyphenated analytical techniques to characterize the selenoproteome of salmon liver tissue. The results and challenges related to the analytical work will be presented and the presentation will show how bioinformatics data can be combined with analytical data to study selenoproteomes in fish.

Published
2018

22. Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean

Author

Nøstbakken, Ole Jakob, primary, Duinker, Arne, additional, Rasinger, Josef D., additional, Nilsen, Bente M., additional, Sanden, Monica, additional, Frantzen, Sylvia, additional, Hove, Helge T., additional, Lundebye, Anne-Katrine, additional, Berntssen, Marc H.G., additional, Hannisdal, Rita, additional, Madsen, Lise, additional, and Maage, Amund, additional

Published
2018
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25. Lower levels of Persistent Organic Pollutants, metals and the marine omega 3-fatty acid DHA in farmed compared to wild Atlantic salmon ( Salmo salar )

Author

Lundebye, Anne-Katrine, primary, Lock, Erik-Jan, additional, Rasinger, Josef D., additional, Nøstbakken, Ole Jakob, additional, Hannisdal, Rita, additional, Karlsbakk, Egil, additional, Wennevik, Vidar, additional, Madhun, Abdullah S., additional, Madsen, Lise, additional, Graff, Ingvild Eide, additional, and Ørnsrud, Robin, additional

Published
2017
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27. The effect of dietary lipid composition on the intestinal uptake and tissue distribution of benzo[ a ]pyrene and phenanthrene in Atlantic salmon ( Salmo salar )

Author

de Gelder, Stefan, primary, Bakke, Marit J., additional, Vos, Joëlle, additional, Rasinger, Josef D., additional, Ingebrigtsen, Kristian, additional, Grung, Merete, additional, Ruus, Anders, additional, Flik, Gert, additional, Klaren, Peter H.M., additional, and Berntssen, Marc H.G., additional

Published
2016
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29. Identification and evaluation of potentially mutagenic and carcinogenic food contaminants.

Author

German Federal Institute for Risk Assessment (BfR), Department Food Safety, Berlin, Germany, Rasinger, Josef D., Frenzel, Falko, Braeuning, Albert, and Lampen, Alfonso

Subjects
MUTAGENS, CARCINOGENS, FOOD contamination, FOOD toxicology, METABOLITES
Abstract

Abstract: Heat processing of food gives rise to a plethora of chemical compounds whose toxicological effects are largely unknown. Due to a general lack of experimental toxicological data, assessing the risks associated with the consumption of these substances remains a challenge. Computer models that allow for an in silico prediction of physicochemical and toxicological characteristics, may be able to fill current data gaps and facilitate the risk assessment of toxicologically uncharacterised chemicals, their transformation products and their biological metabolites. The overall aims of the present project were for the fellow: (i) to get acquainted with the application of computational toxicological analyses tools in risk assessment based on results and experiences from previous research performed at the German Federal Institute for Risk Assessment (BfR); and (ii) to apply the newly gained skills on historic and novel data using updated and additional in silico tools. The project contributed to the continuous further education of the fellow in the use of computational toxicology tools, corroborated findings related to the safety of heat‐induced contaminants and laid the foundations for future collaborations between the fellow's home institution, the Institute of Marine Research (IMR) in Norway, and the BfR in Germany. [ABSTRACT FROM AUTHOR]

Published
2018
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32. A study of selenoproteins in atlantic salmon (Salmo salar) using hyphenated mass spectrometry and bioinformatics

Author

Veronika Sele, Magali Perez, Andrea Raab, Marco Mariotti, Eva Krupp, Joerg Feldmann, Jens Jørgen Sloth, Robin Ørnsrud, Berntssen, Marc H. G., and Rasinger, Josef D.

Subjects
integumentary system
Abstract

Selenium (Se) is an essential micronutrient for vertebrates and fish. Se is central to the function of selenoproteins, which play key roles in many biological functions including redox signaling, antioxidant defense, hormone metabolism, and immune responses. The number and expression levels of selenoproteins vary between different animal species with teleost fish featuring a much higher number of selenoproteins compared to vertebrates. While selenoproteomes have been well described for many species, a comprehensive analysis of selenoproteins in Atlantic salmon (Salmo salar) has yet to be performed. With recent advances in bioinformatics it has become possible to predict selenoproteins using computational tools; however, these in silico predictions description require validation through analytical data. In the present study we applied gel electrophoresis with subsequent use of laser ablation coupled to inductively coupled plasma mass spectrometry (LA-ICP-MS), and tryptic digestion with subsequent analysis with high performance liquid chromatography (HPLC) coupled to both ICPMS and high-resolution tandem electrospray mass spectrometry (HR-ESI-MS) for the analysis ofselenooproteins. Furthermore, we set out to combine theoretical selenoprotein predictions with hyphenated analytical techniques to characterize the selenoproteome of salmon liver tissue. The results and challenges related to the analytical work will be presented and the presentation will show how bioinformatics data can be combined with analytical data to study selenoproteomes in fish.

33. Identification and evaluation of potentially mutagenic and carcinogenic food contaminants.

Author

Rasinger JD, Frenzel F, Braeuning A, and Lampen A

Abstract

Heat processing of food gives rise to a plethora of chemical compounds whose toxicological effects are largely unknown. Due to a general lack of experimental toxicological data, assessing the risks associated with the consumption of these substances remains a challenge. Computer models that allow for an in silico prediction of physicochemical and toxicological characteristics, may be able to fill current data gaps and facilitate the risk assessment of toxicologically uncharacterised chemicals, their transformation products and their biological metabolites. The overall aims of the present project were for the fellow: (i) to get acquainted with the application of computational toxicological analyses tools in risk assessment based on results and experiences from previous research performed at the German Federal Institute for Risk Assessment (BfR); and (ii) to apply the newly gained skills on historic and novel data using updated and additional in silico tools. The project contributed to the continuous further education of the fellow in the use of computational toxicology tools, corroborated findings related to the safety of heat-induced contaminants and laid the foundations for future collaborations between the fellow's home institution, the Institute of Marine Research (IMR) in Norway, and the BfR in Germany., (© 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.)

Published
2018
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