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The article published in the British Journal of Dermatology explores the development of melanoma from pre-existing naevi in individuals with a germline CDKN2A pathogenic variant. The study found that 78% of melanomas in carriers of this variant originated from pre-existing naevi, with total-body photography being a useful tool for surveillance. The findings suggest the importance of routine monitoring and early detection in individuals with a CDKN2A pathogenic variant to prevent melanoma development. The study acknowledges limitations in sample size and patient demographics, emphasizing the need for further research in this area. [Extracted from the article]

A 24-year-old male patient was seen with generalized itch and papules located at the hands. Staining of a papule with a purple medical skin marker, followed by wiping of the ink with an alcohol-gauze revealed an ink-filled burrow. These findings are consistent with a positive burrow ink test, and a clinical diagnosis of scabies was made.