206 results on '"Reik, Andreas"'
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2. Epigenetic control of multiple genes with a lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays
3. Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays
4. Enhancing gene editing specificity by attenuating DNA cleavage kinetics
5. NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease
6. Off-the-shelf, steroid-resistant, IL13Rα2-specific CAR T cells for treatment of glioblastoma
7. A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR
8. Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
9. Isogenic human cell lines for drug discovery: regulation of target gene expression by engineered zinc-finger protein transcription factors
10. Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus
11. Zinc Finger Nuclease-Mediated Disruption of the BCL11A Erythroid Enhancer Results in Enriched Biallelic Editing, Increased Fetal Hemoglobin, and Reduced Sickling in Erythroid Cells Derived from Sickle Cell Disease Patients
12. Analyzing Hormone Regulation of Transcription by Genomic Footprinting
13. Ex Vivo Gene-Edited Cell Therapy for Sickle Cell Disease: Disruption of the BCL11A Erythroid Enhancer with Zinc Finger Nucleases Increases Fetal Hemoglobin in Plerixafor Mobilized Human CD34+ Cells
14. Hormonal and liver-specific control of expression of the tyrosine aminotransferase gene
15. Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major
16. Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy
17. Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity
18. A Potential Therapy for Beta-Thalassemia (ST-400) and Sickle Cell Disease (BIVV003)
19. Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34 + Hematopoietic Stem and Progenitor Cells
20. 641. Highly Efficient, ZFN-Driven Knockout of Surface Expression of the T-Cell Receptor and HLA Class I Proteins in Human T-Cells for Enhancing Allogeneic Adoptive Cell Therapies
21. 752. Single Chain TCR Gene Editing in Adoptive Cell Therapy for Multiple Myeloma
22. Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease
23. Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application
24. Genome Editing of the Bcl11A Erythroid Specific Enhancer in Bone Marrow Derived Hematopoietic Stem and Progenitor Cells for the Treatment of Sickle Cell Disease
25. Clinical-Scale Genome Editing of the Human BCL11A Erythroid Enhancer for Treatment of the Hemoglobinopathies
26. Clonal Analysis of Human Bone Marrow CD34+ Cells Edited By BCL11A-Targeting Zinc Finger Nucleases Reveals Clinically Relevant Levels of Fetal Globin Expression in Edited Erythroid Progeny
27. 185 - A Potential Therapy for Beta-Thalassemia (ST-400) and Sickle Cell Disease (BIVV003)
28. A Potential Therapy for Beta-Thalassemia (ST-400) and Sickle Cell Disease (BIVV003)
29. Identifying mechanisms that limit efficient site-specific gene modification by homology-directed repair in hematopoietic stem cells
30. Functional footprinting of regulatory DNA
31. Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma
32. A novel in vivo chemoselection strategy for genetically modified hematopoietic stem cells
33. 77. Clinical Scale Zinc Finger Nuclease (ZFN)-Driven Gene-Editing of PD-1 in Tumor Infiltrating Lymphocytes (TIL) for the Potential Treatment of Metastatic Melanoma
34. 115. Correction of the Sickle-Cell Disease Mutation in Human Hematopoietic Stem/Progenitor Cells
35. 209. TCR Gene Editing in a Single Step of T Cell Activation To Redirect T Cell Specificity and Prevent GvHD
36. 54. Genome Editing of Primary Human CD34+ Hematopoietic Stem Cells Enables a Safe Harbor Targeted Gene Addition Therapeutic Strategy for Chronic Granulomatous Disease
37. 53. From GWAS To the Clinic: Genome-Editing the Human BCL11A Erythroid Enhancer for Fetal Globin Elevation in the Hemoglobinopathies
38. 239. Preclinical Studies for the First Hematopoietic Stem Cell (HSC) Gene Editing Trial: Phase 1 Study of Beta-Thalassemia With Autologous Transplantation of Zinc Finger Nuclease-Treated HSC To Upregulate Fetal Hemoglobin
39. Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells
40. NY-ESO-1 Single Edited T Cells to Treat Multiple Myeloma without Inducing GvHD
41. Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma
42. Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping
43. ZFN-Driven Gene Editing Prevents HLA-A Expression On Hematopoietic Stem Cells -Improving The Chance Of Finding An HLA-Matched Donor
44. Autologous Hematopoietic Stem/Progenitor Cell (HSPC) Therapy For Monogenic Blood Disorders: Scalable, cGMP-Compliant Process For Generating Highly Efficient Genome Edited HSPC
45. Zinc Finger Nucleases Targeting The β-Globin Locus Drive Efficient Correction Of The Sickle Mutation In CD34+ Cells
46. TCR Gene Editing Achieved In a Single Round Of T Cell Activation Is Sufficient To Redirect T Cell Specificity and Prevent GvHD
47. Targeted Gene Modification In Hematopoietic Stem Cells: A Potential Treatment For Thalassemia and Sickle Cell Anemia
48. Toward eliminating HLA class I expression to generate universal cells from allogeneic donors
49. Controlling long-range genomic interactions to reprogram the β-globin locus
50. Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease.
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