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2. Novel Benchmark Values for Redo Liver Transplantation

Author

Fariba Abbassi, Daniel Gero, Xavier Muller, Alba Bueno, Wojciech Figiel, Fabien Robin, Sophie Laroche, Benjamin Picard, Sadhana Shankar, Tommy Ivanics, Marjolein van Reeven, Otto B. van Leeuwen, Hillary J. Braun, Diethard Monbaliu, Antoine Breton, Neeta Vachharajani, Eliano Bonaccorsi Riani, Greg Nowak, Robert R. McMillan, Samir Abu-Gazala, Amit Nair, Rocio Bruballa, Flavio Paterno, Deborah Weppler Sears, Antonio D. Pinna, James V. Guarrera, Eduardo de Santibañes, Martin de Santibañes, Roberto Hernandez-Alejandro, Kim Olthoff, R Mark Ghobrial, Bo-Göran Ericzon, Olga Ciccarelli, William C. Chapman, Jean-Yves Mabrut, Jacques Pirenne, Beat Müllhaupt, Nancy L. Ascher, Robert J. Porte, Vincent E. de Meijer, Wojciech G. Polak, Gonzalo Sapisochin, Magdy Attia, Olivier Soubrane, Emmanuel Weiss, René A. Adam, Daniel Cherqui, Karim Boudjema, Krzysztof Zieniewicz, Wayel Jassem, Philipp Dutkowski, Pierre-Alain Clavien, Surgery, Faculteit Medische Wetenschappen/UMCG, Groningen Institute for Organ Transplantation (GIOT), UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, and UCL - (SLuc) Service de chirurgie et transplantation abdominale

Subjects
End Stage Liver Disease, retransplantation, Benchmarking, Tissue and Organ Procurement, Treatment Outcome, benchmark, Graft Survival, Humans, Surgery, redo liver transplantation, Liver Transplantation, Retrospective Studies
Abstract

Objective In the era of organ shortage, redo liver transplantation (reLT) is frequently discussed in terms of expected poor outcome, high cost and therefore wasteful resources. However, there is a lack of benchmark data to reliably assess outcomes after reLT. The aim of this study was to define the ideal reLT case, and to establish clinically relevant benchmark values for best achievable outcome in reLT. Methods We collected data on reLT between January 2010 and December 2018 from 22 high volume transplant centers on three continents. Benchmark cases were defined as recipients with model of end-stage liver disease score Results Out of 1110 reLT 413 (37.2%) qualified as benchmark cases. Benchmark values included: Length of intensive care unit and hospital stay: =3a complications and the CCI at 1 year: Conclusion ReLT remains associated with high morbidity and mortality. The availability of benchmark values for outcome parameters of reLT may serve for comparison in any future analyses of individuals, patient groups, or centers, but also in the evaluation of new therapeutic strategies and principles.

Published
2022
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