11 results on '"Renate C. Heine-Bröring"'
Search Results
2. Dietary supplement use and colorectal cancer risk: A systematic review and meta-analyses of prospective cohort studies
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Anne Claire B. van Orten-Luiten, Jacoba M S Renkema, Lea Kragt, Ettje F. Tigchelaar, Renate C. Heine-Bröring, Teresa Norat, Doris S. M. Chan, Renate M. Winkels, and Ellen Kampman
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Vitamin ,Cancer Research ,medicine.medical_specialty ,business.industry ,Colorectal cancer ,Confounding ,medicine.disease ,Surgery ,chemistry.chemical_compound ,Systematic review ,Oncology ,chemistry ,Internal medicine ,Meta-analysis ,Vitamin D and neurology ,Medicine ,business ,Multivitamin ,Prospective cohort study - Abstract
Use of dietary supplements is rising in countries where colorectal cancer is prevalent. We conducted a systematic literature review and meta-analyses of prospective cohort studies on dietary supplement use and colorectal cancer risk. We identified relevant studies in Medline, Embase and Cochrane up to January 2013. Original and peer-reviewed papers on dietary supplement use and colorectal cancer, colon cancer, or rectal cancer incidence were included. "Use-no use"(U-NU), "highest-lowest"(H-L) and "dose-response"(DR) meta-analyses were performed. Random-effects models were used to estimate summary estimates. In total, 24 papers were included in the meta-analyses. We observed inverse associations for colorectal cancer risk and multivitamin (U-NU: RR = 0.92; 95% CI: 0.87,0.97) and calcium supplements (U-NU: RR = 0.86; 95% CI: 0.79,0.95; H-L: RR = 0.80; 95% CI: 0.70,0.92; DR: for an increase of 100 mg/day, RR = 0.96; 95% CI: 0.94,0.99). Inconsistent associations were found for colon cancer risk and supplemental vitamin A and vitamin C, and for colorectal cancer risk and supplemental vitamin D, vitamin E, garlic and folic acid. Meta-analyses of observational studies suggest a beneficial role for multivitamins and calcium supplements on colorectal cancer risk, while the association with other supplements and colorectal cancer risk is inconsistent. Residual confounding of lifestyle factors might be present. Before recommendations can be made, an extensive assessment of dietary supplement use and a better understanding of underlying mechanisms is needed.
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- 2014
3. Dietary supplement use and colorectal cancer risk: a systematic review and meta-analyses of prospective cohort studies
- Author
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Renate C, Heine-Bröring, Renate M, Winkels, Jacoba M S, Renkema, Lea, Kragt, Anne-Claire B, van Orten-Luiten, Ettje F, Tigchelaar, Doris S M, Chan, Teresa, Norat, and Ellen, Kampman
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Adult ,Aged, 80 and over ,Male ,Vitamins ,Middle Aged ,Calcium, Dietary ,Young Adult ,Databases as Topic ,Risk Factors ,Dietary Supplements ,Humans ,Female ,Prospective Studies ,Colorectal Neoplasms ,Aged - Abstract
Use of dietary supplements is rising in countries where colorectal cancer is prevalent. We conducted a systematic literature review and meta-analyses of prospective cohort studies on dietary supplement use and colorectal cancer risk. We identified relevant studies in Medline, Embase and Cochrane up to January 2013. Original and peer-reviewed papers on dietary supplement use and colorectal cancer, colon cancer, or rectal cancer incidence were included. "Use-no use"(U-NU), "highest-lowest"(H-L) and "dose-response"(DR) meta-analyses were performed. Random-effects models were used to estimate summary estimates. In total, 24 papers were included in the meta-analyses. We observed inverse associations for colorectal cancer risk and multivitamin (U-NU: RR = 0.92; 95% CI: 0.87,0.97) and calcium supplements (U-NU: RR = 0.86; 95% CI: 0.79,0.95; H-L: RR = 0.80; 95% CI: 0.70,0.92; DR: for an increase of 100 mg/day, RR = 0.96; 95% CI: 0.94,0.99). Inconsistent associations were found for colon cancer risk and supplemental vitamin A and vitamin C, and for colorectal cancer risk and supplemental vitamin D, vitamin E, garlic and folic acid. Meta-analyses of observational studies suggest a beneficial role for multivitamins and calcium supplements on colorectal cancer risk, while the association with other supplements and colorectal cancer risk is inconsistent. Residual confounding of lifestyle factors might be present. Before recommendations can be made, an extensive assessment of dietary supplement use and a better understanding of underlying mechanisms is needed.
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- 2014
4. The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life
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Moniek van Zutphen, Fränzel J.B. Van Duijnhoven, Renate C. Heine-Bröring, Dieuwertje E. Kok, Renate M. Winkels, Ellen Kampman, and Suzanne A. van Harten-Gerritsen
- Subjects
Oncology ,Male ,Cancer Research ,Nutrition and Disease ,Survival ,Colorectal cancer ,short questionnaire ,body-mass index ,adipose-tissue ,Body composition ,Cohort Studies ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,Study Protocol ,Quality of life ,Risk Factors ,Recurrence ,Voeding en Ziekte ,treatment-related toxicity ,Longitudinal Studies ,Prospective Studies ,Rectal cancer ,Prospective cohort study ,Netherlands ,Cohort ,health ,visceral obesity ,Dietary supplements ,Colon cancer ,Observational Studies as Topic ,Female ,enhancing physical-activity ,Colorectal Neoplasms ,Cohort study ,medicine.medical_specialty ,rectal-cancer ,Internal medicine ,Genetics ,medicine ,Humans ,skeletal-muscle ,Life Style ,Survival analysis ,VLAG ,clinical-trials ,Nutrition ,business.industry ,medicine.disease ,Survival Analysis ,Cancer registry ,Diet ,Quality of life (max 10) ,Nutrition Assessment ,Physical therapy ,Quality of Life ,Neoplasm Recurrence, Local ,business ,Body mass index - Abstract
Contains fulltext : 136946.pdf (Publisher’s version ) (Open Access) BACKGROUND: There is clear evidence that nutrition and lifestyle can modify colorectal cancer risk. However, it is not clear if those factors can affect colorectal cancer treatment, recurrence, survival and quality of life. This paper describes the background and design of the "COlorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life" - COLON - study. The main aim of this study is to assess associations of diet and other lifestyle factors, with colorectal cancer recurrence, survival and quality of life. We extensively investigate diet and lifestyle of colorectal cancer patients at diagnosis and during the following years; this design paper focusses on the initial exposures of interest: diet and dietary supplement use, body composition, nutrient status (e.g. vitamin D), and composition of the gut microbiota. METHODS/DESIGN: The COLON study is a multi-centre prospective cohort study among at least 1,000 incident colorectal cancer patients recruited from 11 hospitals in the Netherlands. Patients with colorectal cancer are invited upon diagnosis. Upon recruitment, after 6 months, 2 years and 5 years, patients fill out food-frequency questionnaires; questionnaires about dietary supplement use, physical activity, weight, height, and quality of life; and donate blood samples. Diagnostic CT-scans are collected to assess cross-sectional areas of skeletal muscle, subcutaneous fat, visceral fat and intermuscular fat, and to assess muscle attenuation. Blood samples are biobanked to facilitate future analyse of biomarkers, nutrients, DNA etc. Analysis of serum 25-hydroxy vitamin D levels, and analysis of metabolomic profiles are scheduled. A subgroup of patients with colon cancer is asked to provide faecal samples before and at several time points after colon resection to study changes in gut microbiota during treatment. For all patients, information on vital status is retrieved by linkage with national registries. Information on clinical characteristics is gathered from linkage with the Netherlands Cancer Registry and with hospital databases. Hazards ratios will be calculated for dietary and lifestyle factors at diagnosis in relation to recurrence and survival. Repeated measures analyses will be performed to assess changes over time in dietary and other factors in relation to recurrence and survival.
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- 2014
5. Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study
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Renate M. Winkels, Ellen Kampman, Akke Botma, Audrey Y. Jung, Fränzel J.B. Van Duijnhoven, Hans F. A. Vasen, Jan H. Kleibeuker, Fokko M. Nagengast, and Renate C. Heine-Bröring
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medicine.medical_specialty ,Multidisciplinary ,business.industry ,Science ,Dietary supplement ,lcsh:R ,Correction ,lcsh:Medicine ,Colorectal adenoma ,medicine.disease ,Lynch syndrome ,Annotation ,Internal medicine ,medicine ,Medicine ,lcsh:Q ,business ,lcsh:Science ,Cohort study - Published
- 2014
6. Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study
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Audrey Y. Jung, J.L. Harryvan, Fränzel J.B. Van Duijnhoven, Renate M. Winkels, Jan H. Kleibeuker, Ellen Kampman, Renate C. Heine-Bröring, Hans F. A. Vasen, Fokko M. Nagengast, Akke Botma, Health Sciences, Prevention and Public Health, EMGO+ - Lifestyle, Overweight and Diabetes, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
- Subjects
Male ,Cancer Research ,Folate ,Nutrition and Disease ,Riboflavin ,body-mass index ,Gene mutation ,Gastroenterology ,Cohort Studies ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,chemistry.chemical_compound ,Methionine ,Risk Factors ,Surveys and Questionnaires ,Voeding en Ziekte ,Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] ,Prospective Studies ,Prospective cohort study ,Netherlands ,biology ,plasma folate ,Middle Aged ,Lynch syndrome ,folic-acid supplementation ,Oncology ,Vitamin B Complex ,Female ,Colorectal adenoma ,Adult ,medicine.medical_specialty ,food-frequency questionnaire ,Genotype ,B vitamins ,OS&DAEB ,White People ,folate intake ,biomarker-based validity ,SDG 17 - Partnerships for the Goals ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Vitamin B12 ,mismatch-repair genes ,nonpolyposis colon-cancer ,Methylenetetrahydrofolate Reductase (NADPH2) ,Proportional Hazards Models ,VLAG ,Global Nutrition ,Wereldvoeding ,business.industry ,cigarette-smoking ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Colorectal cancer ,methylenetetrahydrofolate reductase ,Diet ,Endocrinology ,chemistry ,Case-Control Studies ,Methylenetetrahydrofolate reductase ,biology.protein ,business - Abstract
Contains fulltext : 137784.pdf (Publisher’s version ) (Closed access) PURPOSE: Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high lifetime risk of developing neoplasms. The role of MTHFR C677T genotype in modifying these relationships in LS individuals is also unclear. We investigated associations between dietary intakes of folate, vitamins B2, B6, B12, and methionine and CRT development in a prospective cohort study of 470 mismatch repair gene mutation carriers. METHODS: Dietary intakes were assessed by food frequency questionnaire. Cox regression models with robust sandwich covariance estimation, adjusted for age, sex, physical activity, number of colonoscopies during person-time, NSAID use, and mutual vitamins were used to calculate hazard ratios (HRs) and 95 % confidence intervals (95 % CIs). Analyses were also stratified by MTHFR C677T genotype. RESULTS: During a median person-time of 28.0 months, 131 persons developed a CRT. Fifty-one of these persons developed an incident colorectal adenoma, while there were four persons who developed an incident colorectal carcinoma. Compared to the lowest tertile of intake, adjusted HRs (95 % CIs) for CRT development in the highest tertile were 1.06 (0.59-1.91) for folate, 0.77 (0.39-1.51) for vitamin B2, 0.98 (0.59-1.62) for vitamin B6, 1.24 (0.77-2.00) for vitamin B12, and 1.36 (0.83-2.20) for methionine. Low vitamin B2 and low methionine intake were statistically significantly associated with an increased risk of CRT in MTHFR 677TT individuals compared to a combined reference of persons with low intake and CC genotype. CONCLUSIONS: There was no suggestion that intake of any dietary B vitamin or methionine was associated with CRT development among those with LS.
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- 2014
7. Dietary supplement use is not associated with recurrence of colorectal adenomas: a prospective cohort study
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Fokko M. Nagengast, Renate C. Heine-Bröring, Adriaan C.I.T.L. Tan, Peter J. Wahab, Renate M. Winkels, Ellen Kampman, Ben J.M. Witteman, Akke Botma, Health Sciences, Prevention and Public Health, and EMGO+ - Lifestyle, Overweight and Diabetes
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Male ,Cancer Research ,Nutrition and Disease ,endocrine system diseases ,food frequency questionnaire ,Colonoscopy ,cancer risk ,Gastroenterology ,clinical-trial ,Cohort Studies ,Voeding en Ziekte ,Medicine ,folic-acid ,Prospective Studies ,Prospective cohort study ,Early Detection of Cancer ,medicine.diagnostic_test ,Hazard ratio ,Middle Aged ,health interview survey ,Oncology ,Population study ,Female ,Colorectal Neoplasms ,Cohort study ,Adenoma ,medicine.medical_specialty ,antioxidant vitamins ,life-style ,vitamin-d ,united-states ,Colorectal adenoma ,SDG 3 - Good Health and Well-being ,Translational research [ONCOL 3] ,Internal medicine ,Humans ,Proportional Hazards Models ,Molecular epidemiology Aetiology, screening and detection [NCEBP 1] ,VLAG ,business.industry ,Proportional hazards model ,Feeding Behavior ,medicine.disease ,relative validity ,digestive system diseases ,Diet ,Surgery ,stomatognathic diseases ,Dietary Supplements ,Neoplasm Recurrence, Local ,business - Abstract
Diet and lifestyle influence colorectal adenoma recurrence. The role of dietary supplement use in colorectal adenoma recurrence remains controversial. In this prospective cohort study, we examined the association between dietary supplement use, total colorectal adenoma recurrence and advanced adenoma recurrence. Colorectal adenoma cases (n = 565) from a former case-control study, recruited between 1995 and 2002, were prospectively followed until 2008. Adenomas with a diameter of ≥1 cm and/or (tubulo)villous histology and/or with high grade dysplasia and/or ≥3 adenomas detected at the same colonic examination were considered advanced adenomas. Hazard ratios (HRs) and 95% confidence intervals (CIs) for dietary supplement users (use of any supplement during the past year) compared to nonusers and colorectal adenoma recurrence were calculated using stratified Cox proportional hazard models for counting processes and were adjusted for age, sex, educational level and number of colonoscopies during follow-up. Robust sandwich covariance estimation was used to adjust for the within subject correlation. A number of 165 out of 565 adenoma patients had at least one colorectal adenoma recurrence during a median person-time of 5.4 years and of these, 37 patients had at least one advanced adenoma. One-third of the total study population (n = 203) used a dietary supplement. Compared to no use, dietary supplement use was neither statistically significantly associated with total colorectal adenoma recurrence (HR = 1.03; 95% CI 0.79-1.34) nor with recurrent advanced adenomas (HR = 1.59; 95% CI 0.88-2.87). This prospective cohort study did not suggest an association between dietary supplement use and colorectal adenoma recurrence. What's new? People take vitamins and other dietary supplements for many reasons, but could your supplements be harmful? Heine-Bröring et al. investigated the effects of dietary supplements on colorectal adenomas, to better advise those at risk. Colorectal cancer is one of the most common types of cancer in the Western world, and one red flag for clinicians is the presence of colorectal adenomas. Patients who develop these asymptomatic growths have an increased risk of colorectal cancer. As more and more people have begun taking multivitamin supplements, it is important to know how to advise patients with recurrent colorectal adenomas regarding dietary supplements. The researchers conducted a cohort study, including 203 dietary supplement users and 362 nonusers, and looked at the relative frequency of colorectal adenomas in each group. Their results showed that taking dietary supplements such as vitamin C, calcium, or multivitamins did not reduce or increase a person's risk of colorectal adenoma recurrence. Use of B-vitamin supplements, however, were associated with an increase in total recurrent colorectal adenomas, but not with recurrent adenomas that showed advanced pathology. © 2012 UICC.
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- 2013
8. Diet and colorectal cancer risk and survival
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F. J. B. van Duijnhoven, Renate M. Winkels, Ellen Kampman, Renate C. Heine-Bröring, Health Sciences, Prevention and Public Health, and EMGO+ - Lifestyle, Overweight and Diabetes
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Oncology ,medicine.medical_specialty ,Nutrition and Disease ,Colorectal cancer ,business.industry ,Gastroenterology ,Cancer ,Overweight ,medicine.disease ,Lifestyle factors ,Fruits and vegetables ,Internal medicine ,Voeding en Ziekte ,medicine ,Life Science ,Processed meat ,Dietary fiber ,medicine.symptom ,business ,VLAG - Abstract
SUMMARY Unhealthy dietary and other lifestyle factors account for 20–45% of all colorectal cancer cases. Being overweight or obese, having a high intake of red and processed meat and alcohol increase the risk of colorectal cancer, while a high intake of dairy products, fruits and vegetables, foods containing dietary fiber and being physically active lower the risk of colorectal cancer. There are only a limited number of studies available on diet and outcomes in colorectal cancer survivors. Most of these studies are retrospective in nature, and are small in size, which makes it difficult to draw conclusions. However, the available studies to date putatively suggest that lifestyle factors lowering the risk of colorectal cancer are also beneficial for cancer survivors.
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- 2013
9. Intake of fish and marine n-3 fatty acids in relation to coronary calcification: the Rotterdam Study
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Albert Hofman, Jacqueline C.M. Witteman, Johanna M. Geleijnse, Rozemarijn Vliegenthart Proenca, Matthijs Oudkerk, Ingeborg A. Brouwer, Renate C. Heine-Bröring, Frank J. A. van Rooij, Epidemiology, Nutrition and Health, and EMGO+ - Lifestyle, Overweight and Diabetes
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Male ,Nutrition and Disease ,computed-tomography ,cardiovascular-disease ,Medicine (miscellaneous) ,Physiology ,Coronary Disease ,Severity of Illness Index ,SUPPLEMENTATION ,risk prediction ,Rotterdam Study ,Crustacea ,Voeding en Ziekte ,Netherlands ,education.field_of_study ,Nutrition and Dietetics ,Smoking ,Fishes ,Calcinosis ,Middle Aged ,Eicosapentaenoic acid ,Eicosapentaenoic Acid ,Docosahexaenoic acid ,CARDIOVASCULAR-DISEASE ,controlled-trial ,Hypertension ,Educational Status ,Female ,Dietary Proteins ,medicine.symptom ,metaanalysis ,medicine.medical_specialty ,Alcohol Drinking ,Docosahexaenoic Acids ,Population ,Hypercholesterolemia ,HEART-DISEASE ,CONTROLLED-TRIAL ,Asymptomatic ,SDG 3 - Good Health and Well-being ,Internal medicine ,Fatty Acids, Omega-3 ,medicine ,Animals ,Humans ,COMPUTED-TOMOGRAPHY ,SDG 14 - Life Below Water ,education ,omega-3-fatty-acids ,Exercise ,artery calcium score ,Unsaturated fatty acid ,Triglycerides ,METAANALYSIS ,Aged ,VLAG ,Global Nutrition ,Wereldvoeding ,RISK PREDICTION ,business.industry ,Cholesterol, HDL ,medicine.disease ,heart-disease ,Diet ,ARTERY CALCIUM SCORE ,Endocrinology ,Socioeconomic Factors ,ATHEROSCLEROSIS ,supplementation ,atherosclerosis ,business ,Body mass index ,Calcification ,OMEGA-3-FATTY-ACIDS - Abstract
Background: Epidemiologic and experimental data suggest a cardioprotective effect of n23 (omega-3) fatty acids from fish [eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA)]. Objective: The objective was to examine the association of fish and EPA plus DHA intakes with coronary calcification in a general older population. Design: Diet was assessed between 1990 and 1993 by using a semiquantitative 170-item food-frequency questionnaire. Coronary calcification was assessed ≈7 y later by electron-beam computed tomography in 1570 asymptomatic cardiac subjects with complete dietary data (44% men, mean age of 64 y). Calcium scores according to Agatston's method were divided into ≤10 (no/minimal coronary calcification), 11-400 (mild/moderate calcification), and >400 (severe calcification). Prevalence ratios (PRs) for mild/moderate and severe calcification were obtained in categories of fish and EPA plus DHA intake. PRs were adjusted for age, sex, body mass index, diabetes mellitus, socioeconomic status, smoking, alcohol intake, physical activity, and dietary factors. Results: Subjects with a fish intake >19 g/d had a significantly lower prevalence of mild/moderate calcification (PR: 0.87; 95% CI: 0.78, 0.98; full model) than did subjects who consumed no fish. Subjects with a high fish intake also had a lower prevalence of severe calcifi-cation (PR: 0.88; 95% CI: 0.74, 1.04), which was borderline statistically significant. EPA plus DHA intake showed no significant associations (PR: 0.93 and 0.97, respectively; P > 0.05). Conclusions: We found a weak inverse association between fish intake and coronary calcification. If confirmed in other population-based studies, more research is warranted to determine which components in fish can inhibit vascular calcification. © 2010 American Society for Nutrition.
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- 2010
10. Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study
- Author
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Audrey Y. Jung, Renate C. Heine-Bröring, Renate M. Winkels, Ellen Kampman, Hans F. A. Vasen, Fokko M. Nagengast, Jan H. Kleibeuker, Fränzel J.B. Van Duijnhoven, Akke Botma, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Health Sciences, Prevention and Public Health, and EMGO+ - Lifestyle, Overweight and Diabetes
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Male ,validity ,Pathology ,Nutrition and Disease ,Epidemiology ,lcsh:Medicine ,population ,Gene mutation ,DNA Mismatch Repair ,prevention ,Voeding en Ziekte ,Gastrointestinal Cancers ,Medicine ,Clinical Epidemiology ,Prospective Studies ,lcsh:Science ,Prospective cohort study ,Epidemiological Methods ,education.field_of_study ,Multidisciplinary ,vitamin ,Colonoscopy ,Vitamins ,families ,Middle Aged ,Lynch syndrome ,Population study ,Female ,Colorectal Neoplasms ,Multivitamin ,Cancer Epidemiology ,metaanalysis ,Research Article ,Cohort study ,Adenoma ,Adult ,Colon Anatomy and Development ,medicine.medical_specialty ,Clinical Research Design ,Colon ,Population ,Gastroenterology and Hepatology ,Colorectal adenoma ,Translational research [ONCOL 3] ,Internal medicine ,cancer ,Humans ,gene ,education ,omega-3-fatty-acids ,Molecular epidemiology Aetiology, screening and detection [NCEBP 1] ,VLAG ,Nutrition ,business.industry ,questionnaire ,lcsh:R ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Dietary Supplements ,Mutation ,lcsh:Q ,business - Abstract
Contains fulltext : 118282.pdf (Publisher’s version ) (Open Access) BACKGROUND AND AIMS: Individuals with Lynch syndrome have a high lifetime risk of developing colorectal tumors. In this prospective cohort study of individuals with Lynch syndrome, we examined associations between use of dietary supplements and occurrence of colorectal adenomas. MATERIALS AND METHODS: Using data of 470 individuals with Lynch syndrome in a prospective cohort study, associations between dietary supplement use and colorectal adenoma risk were evaluated by calculating hazard ratios (HR) and 95% confidence intervals (CI) using cox regression models adjusted for age, sex, and number of colonoscopies during person time. Robust sandwich covariance estimation was used to account for dependency within families. RESULTS: Of the 470 mismatch repair gene mutation carriers, 122 (26.0%) developed a colorectal adenoma during an overall median person time of 39.1 months. 40% of the study population used a dietary supplement. Use of any dietary supplement was not statistically significantly associated with colorectal adenoma risk (HR = 1.18; 95%CI 0.80-1.73). Multivitamin supplement use (HR = 1.15; 95%CI 0.72-1.84), vitamin C supplement use (HR = 1.57; 95%CI 0.93-2.63), calcium supplement use (HR = 0.69; 95%CI 0.25-1.92), and supplements containing fish oil (HR = 1.60; 95%CI 0.79-3.23) were also not associated with occurrence of colorectal adenomas. CONCLUSION: This prospective cohort study does not show inverse associations between dietary supplement use and occurrence of colorectal adenomas among individuals with Lynch syndrome. Further research is warranted to determine whether or not dietary supplement use is associated to colorectal adenoma and colorectal cancer risk in MMR gene mutation carriers.
- Published
- 2013
11. Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study.
- Author
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Renate C Heine-Bröring, Renate M Winkels, Akke Botma, Fränzel J B van Duijnhoven, Audrey Y Jung, Jan H Kleibeuker, Fokko M Nagengast, Hans F A Vasen, and Ellen Kampman
- Subjects
Medicine ,Science - Abstract
Individuals with Lynch syndrome have a high lifetime risk of developing colorectal tumors. In this prospective cohort study of individuals with Lynch syndrome, we examined associations between use of dietary supplements and occurrence of colorectal adenomas.Using data of 470 individuals with Lynch syndrome in a prospective cohort study, associations between dietary supplement use and colorectal adenoma risk were evaluated by calculating hazard ratios (HR) and 95% confidence intervals (CI) using cox regression models adjusted for age, sex, and number of colonoscopies during person time. Robust sandwich covariance estimation was used to account for dependency within families.Of the 470 mismatch repair gene mutation carriers, 122 (26.0%) developed a colorectal adenoma during an overall median person time of 39.1 months. 40% of the study population used a dietary supplement. Use of any dietary supplement was not statistically significantly associated with colorectal adenoma risk (HR = 1.18; 95%CI 0.80-1.73). Multivitamin supplement use (HR = 1.15; 95%CI 0.72-1.84), vitamin C supplement use (HR = 1.57; 95%CI 0.93-2.63), calcium supplement use (HR = 0.69; 95%CI 0.25-1.92), and supplements containing fish oil (HR = 1.60; 95%CI 0.79-3.23) were also not associated with occurrence of colorectal adenomas.This prospective cohort study does not show inverse associations between dietary supplement use and occurrence of colorectal adenomas among individuals with Lynch syndrome. Further research is warranted to determine whether or not dietary supplement use is associated to colorectal adenoma and colorectal cancer risk in MMR gene mutation carriers.
- Published
- 2013
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