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A study conducted by Seoul National University College of Medicine compared the resumption of ovulation in women with polycystic ovary syndrome (PCOS) after stopping oral contraceptives (OCPs) or cyclic medroxyprogesterone acetate (MPA). The research found that the odds of ovulation resumption were similar for women who used MPA and OCPs, with 18.4% of MPA users and 24.3% of OCP users experiencing ovulation after stopping the medication. The study suggests that cyclic MPA could be a viable alternative to OCPs for women with PCOS who cannot take OCPs or choose not to. [Extracted from the article]

A clinical trial, NCT06679491, is investigating the impact of menstrual cycle-based resistance training on neuromuscular function in female athletes. The study aims to determine if adjusting training intensity according to menstrual phases improves knee extensor strength and other neuromuscular abilities. Participants will undergo 2 weekly resistance training sessions over 13 weeks, with intensity adjustments based on menstrual phase, and complete periodic neuromuscular assessments across three menstrual phases. The trial involves natural menstrual cycle groups and an oral contraceptive control group to assess the influence of menstrual phase-specific training on neuromuscular adaptations. [Extracted from the article]

The clinical trial NCT06679543 aims to investigate the effects of partial sleep deprivation on cardiac output during cycling exercise in young healthy adults, with a focus on potential sex differences. Participants will undergo testing after a night of normal sleep and partial sleep deprivation, keeping a diary of their sleep and food intake. The study will assess hemodynamic parameters and plasma volume during exercise to determine the impact of sleep deprivation on cardiovascular function. [Extracted from the article]

A recent study conducted in Sao Paulo, Brazil, examined the relationship between hemoglobin concentration, oral contraceptive use, food insecurity, and dietary iron availability in women aged 20-44. The study found that women with higher dietary iron availability and those using oral contraceptives were less likely to have low hemoglobin concentrations, while those experiencing food insecurity were more likely to have low hemoglobin levels. The research, which was peer-reviewed, sheds light on the complex interplay between these factors in socially vulnerable areas of northeastern Brazil. [Extracted from the article]

Femasys Inc. has been issued a patent for methods and devices for controlled delivery, specifically focusing on occluding conduits in humans or animals. The patent details a contraceptive device that can deliver occlusive materials to fallopian tubes without the need for removal or repositioning. The device aims to enhance fertility, treat tubal disorders, infections, and cancer near the fallopian tubes. The patent emphasizes the importance of designing medical devices that control how they are used to ensure better medical outcomes. [Extracted from the article]

The article discusses a clinical trial, NCT06666036, focused on increasing first-time mothers' use of postpartum family planning and improving postnatal care in Bangladesh. The trial aims to strengthen existing health systems and community-level efforts to enhance uptake of family planning and postnatal care among first-time mothers. The study will evaluate the impact of these interventions through a cluster randomized control trial, with a focus on adolescent and young first-time mothers in Bangladesh. The trial is ongoing and aims to contribute to scalable and effective approaches for improving maternal and neonatal outcomes in the region. [Extracted from the article]

Researchers at the University of Western Ontario conducted a study on the effects of current oral contraceptive use on depression in women. The study found that implicit measures of depressive affect were more pronounced during active hormone intake, especially in women who reported high levels of depressive affect. However, self-perceptions indicated that negative symptoms were perceived to be greater during the 'off' phase of the contraceptive cycle. The findings suggest a potential link between oral contraceptive usage and depressive mood effects, emphasizing the importance of including implicit measures in mood assessment. [Extracted from the article]

A study conducted at the University of Auckland examined the impact of the oral contraceptive pill (OCP) on the postprandial glycaemic response to an oral glucose bolus in healthy young women. The research found that in androgenic pill users, postprandial glucose and insulin responses were significantly higher during the active phase of OCP usage compared to the inactive phase. This suggests a potential acute negative effect of the combined OCP on glucose homeostasis, particularly in users of formulations containing androgenic progestogens. Further investigation into the cumulative effects of prolonged OCP use on metabolic risk is warranted. [Extracted from the article]

A recent study conducted by researchers at the Medical University of Warsaw in Poland focused on the side effects, concerns, and discontinuation patterns of oral contraceptive pills (OCPs) among Polish women. The study found that 79% of OCP users experienced adverse effects, with decreased libido and weight gain being the most common reasons for discontinuation. The research highlighted the importance of healthcare professionals providing comprehensive counseling to address concerns and improve compliance among young women using OCPs. [Extracted from the article]

The University of Texas School of Public Health conducted a study comparing the use of contraception by Title X clients and clients of other providers from 2015 to 2019. The research found that Title X clients were more likely to use long-acting reversible contraceptives and hormonal methods other than oral contraceptives. The study highlights the importance of ongoing research to monitor changes in contraceptive use patterns over time. [Extracted from the article]

The article explores the gynaecological health patterns and motherhood experiences of female professional football players through an online questionnaire. Findings show that cycle irregularities and menstrual symptoms are common among participants, with a majority using hormonal contraceptives, particularly oral contraceptive pills. While body satisfaction scores were normal, there was a higher-than-expected drive for thinness score, and the rate of motherhood among professional football players was low. The study highlights the unique health challenges faced by female athletes in elite sports. [Extracted from the article]

A recent study conducted by the Centre of Postgraduate Medical Education in Warsaw, Poland, focused on the impact of gut microbiota and oral contraceptive use in women with Polycystic Ovary Syndrome (PCOS). The study aimed to evaluate changes in gut microbiota before and after treatment with oral contraceptives in women with PCOS. The research concluded that oral contraceptive treatment did not significantly affect the gut microbiota in patients with PCOS in a short observation period. Well-designed randomized controlled studies with unified sample sizes are needed to further explore this topic. [Extracted from the article]

A recent study conducted by researchers from NHS Grampian in Aberdeen, United Kingdom, focused on preventing the recurrence of endometriosis-related pain through long-acting progestogen therapy. The study compared the effectiveness of long-acting progestogen therapy with the combined oral contraceptive pill in reducing pain and improving quality of life for women with endometriosis. While both treatments showed improvement in pain scores, there was no significant difference between the two groups. The study suggested that long-acting reversible contraceptives may be preferable for some women due to lower rates of repeat surgery. [Extracted from the article]

A recent report from the Health Sciences Institute discusses the relationship between oxidative stress and polycystic ovary syndrome (PCOS). PCOS is a hormonal disorder associated with metabolic risks. The report highlights the need for further study on the impact of combined oral contraceptives (COCs) on oxidative stress in women with PCOS. The study found that women with PCOS who used COCs had reduced levels of oxidative stress markers compared to those who did not use COCs. These findings provide new insights into the pathophysiology of PCOS in the Chilean population. [Extracted from the article]

A recent study conducted by researchers at the AJ Institute of Medical Sciences and Research Centre in Karnataka, India, explores the impact of combined oral contraceptives (COCs) on menstrual migraines (MM). The review found inconsistent results, with some studies suggesting that COCs can worsen migraine symptoms, while others indicate a decrease in frequency and severity, particularly with continuous use. The researchers emphasize the importance of choosing contraceptives that are suitable for individual patients, taking into account the potential for increased migraine frequency or the onset of migraines with aura. They recommend further studies to establish clear clinical guidelines and the development of personalized treatment plans that balance migraine management with overall health risks. [Extracted from the article]

A recent meta-analysis examined the Congruency Hypothesis, which suggests that women who change their hormonal contraceptive use after meeting their partner will have lower sexual satisfaction compared to women who do not change their oral contraceptive use. The analysis found that for studies using between-subjects designs, there was no statistically significant correlation between congruency and sexual satisfaction. However, for studies using within-subjects designs, there was a statistically significant correlation, although weak, in favor of the Congruency Hypothesis. Overall, the results suggest that changing oral contraceptive use is unlikely to have a substantial effect on women's sexual satisfaction with their partner. Further research, ideally in the form of randomized controlled trials, is needed to provide a definitive answer. [Extracted from the article]

A recent study conducted by researchers at San Diego State University explored the potential benefits of consuming prunes in mitigating the adverse effects of oral contraceptives (OCs) on bone health in young adult women. The study involved 90 women who were randomly assigned to different groups, including a control group not using OCs, an OC group not consuming prunes, and an OC group consuming 50g of prunes daily. The researchers found that consuming prunes tended to have a potential protective effect on trabecular density of the distal tibia and ultradistal radius, while OC use had minor negative effects on bone. The study suggests that prunes could be a safe and inexpensive solution to prevent bone loss associated with OC use. [Extracted from the article]

A study published in Current Developments in Nutrition suggests that eating a serving of prunes daily for a year may help reduce the risk of bone loss associated with oral contraception use in women aged 18 to 25. The study found that bone mineral density at the ultradistal radius increased significantly among women taking oral contraceptives and consuming 50 grams of prunes daily. The exact reasons for this effect are not fully understood, but it is believed that prunes inhibit bone resorption by reducing the activity of osteoclasts. Prunes are nutrient-rich and contain minerals, vitamin K, phenolic compounds, and fiber that are important for bone health. This study expands upon previous research on prunes' effects on bone health, which primarily focused on postmenopausal women. [Extracted from the article]

This document provides information about a clinical trial conducted by Peking University Cancer Hospital & Institute in China. The trial aims to evaluate the effectiveness of Liangxue ointment, a traditional Chinese medicine, in treating hand-foot syndrome (HFS) associated with VEGFR-TKI drugs in patients with malignant tumors. The trial involves applying the ointment twice a day for 14 days, with two courses of treatment. The study is currently recruiting participants, and the completion date is projected to be March 25, 2025. The eligibility criteria for participants are outlined, and the trial is open to both men and women. The document also includes administrative information such as the NCT number and the plan for sharing data. [Extracted from the article]

A study conducted by the Medical University of Innsbruck in Austria examined the effects of oral contraception on lipid profiles in adolescents. The study found that adolescent females who used oral contraceptives had higher levels of total cholesterol, low-density lipoprotein-cholesterol, and triglycerides compared to non-users. These changes in lipid levels are important to consider, especially for adolescents with other risk factors for cardiovascular disease. The study highlights the need for further research on the effects of oral contraception on lipid profiles in adolescents. [Extracted from the article]

This article discusses the gynecological health patterns and motherhood experiences of female professional football players. The study found that cycle irregularities and menstrual symptoms were common among the participants, with 30% experiencing irregularities and 74% experiencing symptoms. Half of the participants used contraceptives, with the majority preferring hormonal contraceptives such as oral contraceptive pills and implants. The study also found that the rate of motherhood among female professional football players was low, and participants had a higher-than-expected drive for thinness. Overall, the findings suggest that gynecological health and reproductive choices among female professional football players may be influenced by their athletic careers. [Extracted from the article]

A recent study conducted by McMaster University in Toronto, Canada, examined the influence of natural menstrual (NAT) and oral contraceptive pill (OCP) cycles on vascular outcomes in premenopausal females. The study found that NAT and OCP phases had minimal influence on vascular function and associated cellular regulation, with the exception of a small effect on brachial artery endothelial function. The researchers concluded that the differences in baseline artery diameter may partially explain this effect. Overall, the study suggests that menstrual and oral contraceptive pill cycles have minimal impact on cardiovascular outcomes in premenopausal females. [Extracted from the article]

A preprint abstract from biorxiv.org discusses a study that investigated the effects of oral contraceptive use on the proteome profiles of African American women with untreated high blood pressure. The study analyzed the levels of 2,941 serum proteins in 51 pre-menopausal women, 13 of whom were oral contraceptive users and 38 were non-users. The results showed that oral contraceptive use was associated with alterations in the plasma proteome, with 31 proteins showing decreased levels and 13 proteins showing increased levels in users. Pathway and gene ontology analyses revealed potential links to cardiovascular disease. This study provides new insights into the proteomic landscape associated with oral contraceptive use among African American women with uncontrolled hypertension. [Extracted from the article]

A recent study conducted at the National University of Singapore Hospital explored the relationship between reproductive factors and the risk of physical frailty among Chinese women living in Singapore. The study found that younger ages at menarche (onset of menstruation) and menopause were associated with a higher likelihood of physical frailty in later life. However, factors such as duration of reproductive period, number of children, and use of oral contraceptives or hormone replacement therapy were not significantly associated with the risk of physical frailty. This population-based cohort study provides valuable insights into the impact of reproductive factors on women's health in Singapore. [Extracted from the article]

A recent report from the Quebec University Hospital Research Center discusses the medical management of endometriosis. The researchers highlight the importance of managing painful symptoms through hormonal and nonhormonal treatments. They summarize recent evidence on various medical management options, including the efficacy of different medications in relieving pain associated with endometriosis. The report suggests that suppressive treatment, such as the combined oral contraceptive pill and progestogens, can be offered to symptomatic women who are not seeking immediate fertility. It also mentions the increasing use of complementary and alternative medicines in managing endometriosis. [Extracted from the article]

A study conducted at the Federal University Santa Catarina in Florianopolis, Brazil, aimed to investigate the effects of oral contraceptive pill intake and menstrual phase on strength, muscle soreness, and recovery after an exercise protocol in trained women. The study involved 26 women, divided into two groups: contraceptive users and non-users. The results showed that perceptual responses to exercise differed between the menstrual and non-menstrual phase, but did not depend on oral contraceptive use. This research provides new insights into the relationship between female contraceptive agents and muscular performance in trained women. [Extracted from the article]

A clinical trial, NCT06546397, is currently recruiting participants to study the effects of combined estrogen and progesterone therapy on endometrial repair and ovarian function recovery after induced abortion. The trial aims to address potential risks associated with repeated induced abortions, such as uterine damage and infertility. The study will evaluate the thickness of the endometrium, cycle normalization rate, duration of vaginal bleeding after surgery, and menstrual flow volume as primary and secondary outcome measures. The study is being conducted in China and is expected to be completed by December 2025. [Extracted from the article]

A study conducted by researchers at the Polytechnic University of Madrid explored how fluctuations in sex hormones may affect bone metabolism in response to running. The study analyzed the concentrations of certain hormones and bone markers in eumenorrheic females and oral contraceptive users during different phases of their menstrual cycle. The findings showed that sex hormone concentrations have an impact on bone metabolism during exercise, with higher post-exercise bone marker concentrations observed in all menstrual cycle phases compared to the active pill-taking phase of the oral contraceptive cycle. This research highlights the importance of studying exercising females with different hormonal profiles to better understand the effects on bone health. [Extracted from the article]

A research study conducted by the Berlin Center for Epidemiology and Health Research (ZEG) compared the safety and effectiveness of two types of female contraceptive agents, NOMAC-E2 and levonorgestrel-containing COCs (COCLNG), in women over the age of 40. The study, which included participants from Europe, Australia, and Latin America, found that NOMAC-E2 did not increase the risk of venous thromboembolism (VTE) compared to COCLNG. Additionally, unintended pregnancy rates were similar between the two groups, and there were no significant differences in mood and weight changes. The researchers concluded that NOMAC-E2 can be considered a valid alternative to COCLNG for perimenopausal women. [Extracted from the article]

A new study conducted by the Berlin Center for Epidemiology and Health Research (ZEG) has found that NOMAC-E2, a type of female contraceptive agent, is more effective at preventing unintended pregnancies in women under 25 compared to levonorgestrel-containing combined oral contraceptives (COCLNG). The study, which followed over 12,000 NOMAC-E2 users and 17,000 COCLNG users, found that the risk of unintended pregnancy was significantly lower in the NOMAC-E2 group. Additionally, the study found no significant differences in acne, mood, and weight changes between the two groups. This research provides valuable insights into contraceptive options for young women. [Extracted from the article]

A report from the University of Pavia in Italy discusses the underutilization of oral contraceptives by Italian women compared to other European women. The researchers highlight the mandatory medical prescription as a significant barrier to accessing oral contraceptives in Italy. They suggest reclassifying oral contraceptives and expanding pharmacy services to increase the use of safe and effective contraceptive methods. The report emphasizes the potential benefits of streamlining access to oral contraception, including improved emotional well-being for women and potential cost savings for the healthcare system. [Extracted from the article]

A study conducted by researchers at the Kirk Kerkorian School of Medicine at UNLV analyzed 1,000 TikTok videos related to oral contraceptives. The study found that the majority of videos contained low-quality and unreliable information, with non-healthcare providers being the main creators. Healthcare professionals who did create videos with reliable information received less engagement than non-healthcare professionals. The study suggests that healthcare providers should be aware of the prevalence of poor-quality information on social media when counseling patients about reproductive health. [Extracted from the article]

A recent study conducted by the University of Chicago Medicine explores the management of amenorrhea (absence of menstruation) in pre-menopausal women with hematologic cancer. The study highlights the additional challenges faced by these women due to menstrual bleeding and cytopenias associated with the disease and its treatment. The researchers conducted a thorough literature review and combined it with clinical expertise to propose a systematic approach for menses prophylaxis and suppression. The study recommends the use of GnRH agonists as the preferred therapy for achieving menses control and amenorrhea, with the addition of oral contraceptives or estrogen therapy as secondary agents. The protocol aims to provide standardization among clinicians and adaptability for patient-specific needs. [Extracted from the article]

A study conducted by researchers at Delta State University investigated the potential of the alkaloid extract of Moringa oleifera leaf (AML) as a tocolytic agent, which is a substance that prevents preterm births by reducing or stopping uterine contractions. The study utilized both in vitro and in silico methods to analyze the effects of AML. The results showed that AML and its active fraction, chloroform fraction of AML (CAML), significantly inhibited spontaneous contractions and had compounds that could interact with receptors and proteins associated with uterine contractions. This suggests that AML and CAML have the potential to be effective tocolytic agents. [Extracted from the article]

This document provides information about a clinical trial investigating the use of Interferon gamma-1b (IFN-g) and Donor Leukocyte Infusion (DLI) as a treatment for relapsed Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) after an allogeneic stem cell transplant (alloSCT). The trial aims to determine the efficacy of this treatment and explore its potential use in other contexts, such as relapsed disease after haploidentical alloSCT and prevention of relapse in patients who can only tolerate reduced-intensity conditioning regimens. The trial is not yet recruiting participants and is expected to be completed by August 2027. The study is being conducted in the United States and is sponsored by the University of Pittsburgh. [Extracted from the article]

A clinical trial, NCT06509503, is currently recruiting participants in Egypt to study the impact of combined oral contraceptive pills (COCs) on migraines. The trial aims to understand how hormonal contraceptive use affects individuals with migraines. The study will involve two groups, one using COCs and the other using non-hormonal contraception, and will evaluate the number of migraine days, reduction in headache frequency, safety of treatment, and other features of migraines. The trial will last for three months and aims to include 400 female migraine patients aged 18-55 years. [Extracted from the article]

A recent review article from Wollongong Hospital in Australia explores the potential interaction between sugammadex, a drug used in anesthesia, and hormonal contraceptives. The review examines recent clinical data and concludes that the interaction between sugammadex and estrogen and progesterone concentrations may not be clinically significant and may even provide some protection against ovulation. However, there is a lack of strong clinical evidence to support or refute claims of a significant impact of sugammadex on contraceptive efficacy. The research suggests that there is no basis for concern regarding the impact of sugammadex on contraception in the perioperative setting. [Extracted from the article]

A study conducted at Sana'a University in Yemen examined the effects of oral contraceptive (OC) use and khat chewing on telomerase levels and tumor suppressor genes in breast cancer patients and normal volunteers. The study involved 140 Yemeni women aged 25-40, including 60 newly diagnosed breast cancer patients and 80 control subjects. The results showed that breast cancer patients had significantly higher levels of telomerase, p53, and p21 compared to the control group. The use of OCs increased telomerase in the control group but had no effect in breast cancer patients, while khat chewing increased p53 in both groups and p21 in breast cancer patients. The combined use of OCs and khat chewing increased telomerase and p53 in the control group and increased p53 and p21 in breast cancer patients. Telomerase was identified as a risk factor for breast cancer, while khat chewing was found to be protective. The study suggests that the combined use of OCs and khat chewing reduces the risk factor of telomerase. [Extracted from the article]

A recent report from the Razi Clinical Research Development Unit discusses the case of a 41-year-old woman with a giant pedunculated hepatic hemangioma, a rare type of benign liver tumor. The woman had been taking oral contraceptives for 10 years and presented with symptoms such as discomfort in the upper quadrant and early satiety. Imaging revealed a solid mass in the liver, and due to the risk of complications, surgical excision was performed. The report emphasizes the importance of imaging to diagnose these tumors and the need for surgery to prevent acute problems like torsion and rupture. [Extracted from the article]

A new report from Hubei University of Medicine in China explores the association between oral contraceptives and cervical cancer. The study, which used data from the National Health and Nutrition Examination Survey, found that contraceptive use was positively associated with an increased risk of cervical cancer. The research also identified specific factors, such as age, BMI, smoking status, and number of sexual partners, that may contribute to the development of cervical cancer. These findings suggest a need for further investigation into the potential risks of oral contraceptives in relation to cervical cancer. [Extracted from the article]

A study conducted by Fudan University in Shanghai, China analyzed the use of tocolytic agents in preterm labor from 2016 to 2021. Tocolytic agents are used to prolong gestational age and prevent immediate preterm birth. The study found that the total number of tocolytic prescriptions and the total cost of tocolytic agents increased over the six-year duration of the study. The top three tocolytic agents used were magnesium sulfate, ritodrine, and nifedipine. The study also identified inappropriate prescriptions and the need for efforts to ensure the safety and appropriateness of maternal medication. [Extracted from the article]

A recent study conducted by Ibis Reproductive Health explored the interest in over-the-counter progestin-only pills among transgender, nonbinary, and gender-expansive individuals in the United States. The study found that 45% of the participants were interested in accessing these contraceptive pills without a prescription. Factors such as age, insurance status, current use of oral contraceptives, education level, sterilization, and use of testosterone for gender affirmation influenced the level of interest. The availability of over-the-counter progestin-only pills has the potential to improve contraceptive access for this population. [Extracted from the article]

A study conducted by researchers from the University of North Carolina examined the association between combined oral contraceptive use and the risk of developing uterine fibroids in African-American women. The study followed fibroid-free participants and used ultrasound imaging to distinguish between incident and prevalent fibroids. The findings showed an inverse association between ever use of combined oral contraceptives and cumulative fibroid incidence. However, no consistent patterns were observed for the duration of or years since last combined oral contraceptive use. This research provides valuable insights into the relationship between contraception and uterine fibroids in African-American women. [Extracted from the article]

A recent study conducted by researchers at the Pennington Biomedical Research Center in Baton Rouge, Louisiana, examined the effects of different forms of hormonal contraception on fatigue and recovery during exercise. The study involved 60 healthy, active women who were either using oral contraceptives, hormonal intrauterine devices, or had regular menstrual cycles. The researchers found that hormonal contraception and hormone phases had minimal impact on fatigue and recovery. However, they noted that elite female athletes may benefit from understanding how different types of hormonal contraception can slightly affect performance and recovery throughout the menstrual cycle. [Extracted from the article]

A preprint abstract from Women's Health Weekly discusses the potential effects of long-term combined oral contraceptive (COC) use on verbal and spatial performance. The study found that there were no significant differences in mental rotation, navigation, or verbal fluency performance between the active pill intake phase and the pill pause phase in long-term COC users. However, androgenic COC-users demonstrated faster navigation speed and higher orientation accuracy compared to anti-androgenic COC-users and non-users. The duration of COC use was associated with better orientation accuracy and decreased phonemic switching production. The study suggests that long-term COC use may have organizational effects on spatial and verbal processing. Please note that this preprint has not been peer-reviewed. [Extracted from the article]

A study conducted by researchers at King's College London aimed to understand the interaction between oral contraceptive use and rheumatoid arthritis (RA) in relation to the risk of venous thromboembolism (VTE). The study analyzed data from a large population-based sample of female adults in the United Kingdom. The results showed that women with RA had a higher risk of VTE compared to unaffected controls, regardless of their use of oral contraceptives or hormone replacement therapy. The study suggests that routine VTE risk assessments should be conducted for all females with RA. [Extracted from the article]