1. The Prognostic Value of G1 Cyclins, p21 and Rb Protein in Patients With Colon Cancer.
- Author
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Palaiologos P, Chrysikos D, Theocharis S, and Kouraklis G
- Subjects
- Adult, Aged, Aged, 80 and over, Colonic Neoplasms chemistry, Colonic Neoplasms mortality, Colonic Neoplasms pathology, Cyclin D1 analysis, Cyclin E analysis, Cyclin-Dependent Kinase Inhibitor p21 analysis, Female, Follow-Up Studies, Humans, Ki-67 Antigen analysis, Ki-67 Antigen metabolism, Male, Middle Aged, Oncogene Proteins analysis, Prognosis, Retinoblastoma Protein analysis, Survival Rate, Colonic Neoplasms metabolism, Cyclin D1 metabolism, Cyclin E metabolism, Cyclin-Dependent Kinase Inhibitor p21 metabolism, G1 Phase, Neoplasm Proteins metabolism, Oncogene Proteins metabolism, Retinoblastoma Protein metabolism
- Abstract
Background/aim: Cyclins D1 and E play different roles in the cell cycle. Cyclin E promotes chromosome instability, whereas cyclin D1 regulates apoptosis of cells. This study evaluated the prognostic significance of G1 cyclins, p21 and pRb in tumor proliferation., Patients and Methods: A total of 102 patients with colon cancer were operated on and staged according to TNM. Follow-up was 2 to 68 months (mean 38.3±16.7 months). Expression of cyclin E and D1 were evaluated using immunohistochemistry., Results: Levels of cyclin E expression were correlated with cyclin D1 expression (p=0.038), p21 expression (p=0.047), and pRb expression (p=0.004). The 5-year survival rate along with prognosis of patients with advanced stage (III, IV) colon cancer and cyclin D1 positive tumors, were significantly worse (p=0.009). Statistically significant association was observed between tumor proliferative capacity Ki-67, cyclin D1 (p=0.009), pRb (p=0.031) and p21 (p=0.050)., Conclusion: Cyclin D1 is highly expressed in advanced stage colon cancer patients, implying a potential prognostic value., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2019
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