1,435 results on '"Ritchie, C"'
Search Results
2. Using a Claims-Based Frailty Index to Investigate Frailty, Survival, and Healthcare Expenditures among Older Adults Hospitalized for COVID-19 at an Academic Medical Center
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Keeney, Tamra, Flom, M., Ding, J., Sy, M., Leung, K., Kim, D. H., Orav, J., Vogeli, C., and Ritchie, C. S.
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- 2023
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3. Screening over Speech in Unselected Populations for Clinical Trials in AD (PROSPECT-AD): Study Design and Protocol
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König, Alexandra, Linz, N., Baykara, E., Tröger, J., Ritchie, C., Saunders, S., Teipel, S., Köhler, S., Sánchez-Benavides, G., Grau-Rivera, O., Gispert, J. D., Palmqvist, S., Tideman, P., and Hansson, O.
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- 2023
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4. Geriatric Conditions and Health Care Utilization Among Older Adults Living in Subsidized Housing
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Kler, SE, Jeon, S, Patel, K, Ritchie, C, Harrison, K, Thomas, K, and Brown, R
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Medical and Health Sciences ,Geriatrics - Published
- 2019
5. PAIN AND EMERGENCY DEPARTMENT USE IN THE LAST MONTH OF LIFE BY OLDER ADULTS WITH DEMENTIA
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Hunt, L, Ritchie, C, Patel, K, Stephens, C, Cataldo, J, and Smith, A
- Published
- 2018
6. Impact of clinical symptoms and diagnosis: the electronic Person-Specific Outcome Measure (ePSOM) development programme
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Saunders, S., Sheehan, S., Muniz-Terrera, G., Luz, S., and Ritchie, C. W.
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- 2022
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7. SIMULATED ABDOMINAL WALL — A VALUABLE EDUCATIONAL TOOL FOR ABDOMINAL WALL RECONSTRUCTION AND SMALL BITE CLOSURE TECHNIQUES
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Smith, O, primary, Ritchie, C, additional, Aylward, K, additional, Green, S, additional, Chitsabesan, P, additional, and Chintapatla, S, additional
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- 2024
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8. A UK-Wide Study Employing Natural Language Processing to Determine What Matters to People about Brain Health to Improve Drug Development: The Electronic Person-Specific Outcome Measure (ePSOM) Programme
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Saunders, Stina, Muniz-Terrera, G., Sheehan, S., Ritchie, C. W., and Luz, S.
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- 2021
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9. Abstract No. 388 Technical and Clinical Outcomes of Inferior Vena Cava and Iliofemoral Venous Reconstruction Using Covered Stents
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Overfield, C., primary, Arora, M., additional, Lewis, A., additional, Toskich, B., additional, Frey, G., additional, Ritchie, C., additional, and Devcic, Z., additional
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- 2024
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10. GWAS for executive function and processing speed suggests involvement of the CADM2 gene
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Ibrahim-Verbaas, CA, Bressler, J, Debette, S, Schuur, M, Smith, AV, Bis, JC, Davies, G, Trompet, S, Smith, JA, Wolf, C, Chibnik, LB, Liu, Y, Vitart, V, Kirin, M, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffmann, P, Karjalainen, J, Lahti, J, Llewellyn, DJ, Schmidt, CO, Mather, KA, Chouraki, V, Sun, Q, Resnick, SM, Rose, LM, Oldmeadow, C, Stewart, M, Smith, BH, Gudnason, V, Yang, Q, Mirza, SS, Jukema, JW, deJager, PL, Harris, TB, Liewald, DC, Amin, N, Coker, LH, Stegle, O, Lopez, OL, Schmidt, R, Teumer, A, Ford, I, Karbalai, N, Becker, JT, Jonsdottir, MK, Au, R, Fehrmann, RSN, Herms, S, Nalls, M, Zhao, W, Turner, ST, Yaffe, K, Lohman, K, van Swieten, JC, Kardia, SLR, Knopman, DS, Meeks, WM, Heiss, G, Holliday, EG, Schofield, PW, Tanaka, T, Stott, DJ, Wang, J, Ridker, P, Gow, AJ, Pattie, A, Starr, JM, Hocking, LJ, Armstrong, NJ, McLachlan, S, Shulman, JM, Pilling, LC, Eiriksdottir, G, Scott, RJ, Kochan, NA, Palotie, A, Hsieh, Y-C, Eriksson, JG, Penman, A, Gottesman, RF, Oostra, BA, Yu, L, DeStefano, AL, Beiser, A, Garcia, M, Rotter, JI, Nöthen, MM, Hofman, A, Slagboom, PE, Westendorp, RGJ, Buckley, BM, Wolf, PA, Uitterlinden, AG, Psaty, BM, Grabe, HJ, Bandinelli, S, and Chasman, DI
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Biological Psychology ,Clinical and Health Psychology ,Psychology ,Genetics ,Basic Behavioral and Social Science ,Aging ,Human Genome ,Brain Disorders ,Behavioral and Social Science ,Mental Health ,Neurosciences ,Aged ,Aged ,80 and over ,Cell Adhesion Molecules ,Cognition ,Cohort Studies ,Executive Function ,Female ,Genetic Association Studies ,Genetic Variation ,Genome-Wide Association Study ,Genomics ,Humans ,Introns ,Male ,Middle Aged ,Neuropsychological Tests ,Polymorphism ,Single Nucleotide ,White People ,gamma-Aminobutyric Acid ,Generation Scotland ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10(-9) after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10(-4)). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10(-15)), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10(-11)) and neuron cell-cell adhesion (P-value=1.48 × 10(-13)). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.
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- 2016
11. Exploratory Learning through Critical Inquiry: Survey of Critical Inquiry Programs at Mid-Sized U.S. Universities
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Foote, Stephanie M., Harrison, David S., Ritchie, C. Michael, and Dyer, Andrew
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Many alternatives exist for setting the delivery, content, direction, tone, and priorities for a Critical Inquiry/Thinking general education program. Review of our university's overall general education program indicated the need, and overwhelming faculty approval, for a program to improve critical thinking skills, to specifically include exploratory learning and improved cognitive abilities. As we moved ahead we formed a Critical Inquiry Committee for in depth, and participative planning. One of the preliminary, investigative steps was to survey peer institution critical inquiry programs. The results of the study are reported below, along with our steps in developing our first year, one credit, general education critical inquiry program. Our paper includes details of our faculty development program and the results of our pilot program implementation. Our full program is scheduled for implementation during fall 2012. (Contains 1 figure and 6 tables.) [For the complete proceedings, "Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Cognition and Exploratory Learning in Digital Age (CELDA) (Madrid, Spain, October 19-21, 2012)," see ED542606.]
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- 2012
12. Self-Administered Cognitive Testing by Older Adults At-Risk for Cognitive Decline
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Tsoy, Elena, Possin, K. L., Thompson, N., Patel, K., Garrigues, S. K., Maravilla, I., Erlhoff, S. J., and Ritchie, C. S.
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- 2020
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13. Differences in composition of symptom clusters between older and younger oncology patients
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Yates, P, Miaskowski, C, Cataldo, JK, Paul, SM, Cooper, BA, Alexander, K, Aouizerat, B, Dunn, L, Ritchie, C, McCarthy, A, and Skerman, H
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Medical and Health Sciences ,Anesthesiology - Abstract
Context Older oncology patients have unique needs associated with the many physical, psychological, and social changes associated with the aging process. The mechanisms underpinning and the impact of these changes are not well understood. Identification of clusters of symptoms is one approach that has been used to elicit hypotheses about the biological and/or psychological basis for variations in symptom experiences. Objectives The purposes of this study were to identify and compare symptom clusters in younger (
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- 2015
14. Structural brain imaging correlates of general intelligence in UK Biobank
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Cox, S.R., Ritchie, S.J., Fawns-Ritchie, C., Tucker-Drob, E.M., and Deary, I.J.
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- 2019
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15. MSR71 Projecting the Potential Impact of Disease Modifying Therapy on the Future Health and Social Costs of Alzheimer’s Disease
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Trepel, D., primary, Edwards, S., additional, Ritchie, C., additional, Hahn-Pedersen, J.H., additional, Kettle, J., additional, Chan, M.S., additional, Bray, B.D., additional, Clark, A., additional, Ivkovic, M., additional, Wichmann, C.A., additional, and Evans, L.M., additional
- Published
- 2023
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16. Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers
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Audrain, C., Auffret, A., Bakardjian, H., Baldacci, F., Batrancourt, B., Benakki, I., Benali, H., Bertin, H., Bertrand, A., Boukadida, L., Cacciamani, F., Causse, V., Cavedo, E., Cherif Touil, S., Chiesa, P.A., Colliot, O., Dalla Barba, G., Depaulis, M., Dos Santos, A., Dubois, B., Dubois, M., Epelbaum, S., Fontaine, B., Francisque, H., Gagliardi, G., Genin, A., Genthon, R., Glasman, P., Gombert, F., Habert, M.O., Hampel, H., Hewa, H., Houot, M., Jungalee, N., Kas, A., Kilani, M., La Corte, V., Le Roy, F., Lehericy, S., Letondor, C., Levy, M., Lista, S., Lowrey, M., Ly, J., Makiese, O., Masetti, I., Mendes, A., Metzinger, C., Michon, A., Mochel, F., Nait Arab, R., Nyasse, F., Perrin, C., Poirier, F., Poisson, C., Potier, M.C., Ratovohery, S., Revillon, M., Rojkova, K., Santos-Andrade, K., Schindler, R., Servera, M.C., Seux, L., Simon, V., Skovronsky, D., Thiebaut, M., Uspenskaya, O., Vlaincu, M., Aguilar, L.F., Babiloni, C., Benda, N., Black, K.L., Bokde, A.L.W., Bonuccelli, U., Broich, K., Bun, R.S., Cacciola, F., Castrillo, J., Ceravolo, R., Coman, C.M., Corvol, J.C., Cuello, A.C., Cummings, J.L., Depypere, H., Duggento, A., Durrleman, S., Escott-Price, V., Federoff, H., Ferretti, M.T., Fiandaca, M., Frank, R.A., Garaci, F., George, N., Giorgi, F.S., Graziani, M., Haberkamp, M., Herholz, K., Karran, E., Kim, S.H., Koronyo, Y., Koronyo-Hamaoui, M., Lamari, F., Langevin, T., Lehéricy, S., Lorenceau, J., Mapstone, M., Neri, C., Nisticò, R., Nyasse-Messene, F., O'Bryant, S.E., Perry, G., Ritchie, C., Rossi, S., Santarnecchi, E., Schneider, L.S., Sporns, O., Toschi, N., Verdooner, S.R., Vergallo, A., Villain, N., Welikovitch, L., Woodcock, J., Younesi, E., Vergallo, Andrea, Bun, René-Sosata, Toschi, Nicola, Baldacci, Filippo, Zetterberg, Henrik, Blennow, Kaj, Cavedo, Enrica, Lamari, Foudil, Habert, Marie-Odile, Dubois, Bruno, Floris, Roberto, Garaci, Francesco, Lista, Simone, and Hampel, Harald
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- 2018
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17. Differences in the symptom experience of older versus younger oncology outpatients: A cross-sectional study
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Cataldo, Janine, Cataldo, JK, Paul, S, Cooper, B, Skerman, H, Alexander, K, Aouizerat, B, Blackman, V, Merriman, J, Dunn, L, and Ritchie, C
- Abstract
Background: Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may be that older patients received subs
- Published
- 2013
18. Differences in the symptom experience of older versus younger oncology outpatients: A cross-sectional study
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Cataldo, JK, Paul, S, Cooper, B, Skerman, H, Alexander, K, Aouizerat, B, Blackman, V, Merriman, J, Dunn, L, Ritchie, C, Yates, P, and Miaskowski, C
- Abstract
Background: Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may be that older patients received substandard treatment because of concerns about adverse effects. Given the paucity of research on the multiple dimensions of the symptom experience in older oncology patients, the purpose of this study was to evaluate for differences in ratings of symptom occurrence, severity, frequency, and distress between younger (< 60 years) and older ( ≥ 60 years) adults undergoing cancer treatment. We hypothesized that older patients would have significantly lower ratings on four symptom dimensions.Methods: Data from two studies in the United States and one study in Australia were combined to conduct this analysis. All three studies used the MSAS to evaluate the occurrence, severity, frequency, and distress of 32 symptoms.Results: Data from 593 oncology outpatients receiving active treatment for their cancer (i.e., 44.4% were < 60 years and 55.6% were ≥ 60 years of age) were evaluated. Of the 32 MSAS symptoms, after controlling for significant covariates, older patients reported significantly lower occurrence rates for 15 (46.9%) symptoms, lower severity ratings for 6 (18.9%) symptoms, lower frequency ratings for 4 (12.5%) symptoms, and lower distress ratings for 14 (43.8%) symptoms.Conclusions: This study is the first to evaluate for differences in multiple dimensions of symptom experience in older oncology patients. For almost 50% of the MSAS symptoms, older patients reported significantly lower occurrence rates. While fewer age-related differences were found in ratings of symptom severity, frequency, and distress, a similar pattern was found across all three dimensions. Future research needs to focus on a detailed evaluation of patient and clinical characteristics (i.e., type and dose of treatment) that explain the differences in symptom experience identified in this study. © 2013 Cataldo et al.; licensee BioMed Central Ltd.
- Published
- 2013
19. The development and evaluation of the Derivative Model approach to improving ICT usability
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Macefield, Ritchie C. P.
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005.3 - Abstract
A novel approach to improving the usability of contemporary pervasive ICT systems, through the provision of an accurate conceptual model, was developed. The approach was then investigated through a 'proof of concept' study to evaluate whether rt was viable and would improve the usability of a system. Much of this work is related to that published in Macefield (2005a, 2005b, 2007b). The approach considered is termed the Derivative Model approach because the conceptual model provided to the user is derived from the conceptual model used by the designers of the system, and as a result is an accurate explanation of the system's conceptual model. This approach offers users both an Interface View and a Structural View of the system. The Interface View is designed to engender better functional mental models in the user. The Structural View is designed to engender better structural mental models in the user.
- Published
- 2007
20. Structural and spectroscopic studies on solid-state emissive organic fluorophores
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McDonald, P., primary, Xu, J., additional, Jones, I., additional, Moggach, S. A., additional, and Ritchie, C., additional
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- 2023
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21. Structural and spectroscopic studies of photo-switchable molecular capsule
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Choudhari, M., primary and Ritchie, C., additional
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- 2023
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22. Photochromic molecular assemblies of polyoxometallates and diarylethenes
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Choudhari, M., primary, Xu, J., additional, McKay, A., additional, Guerrin, C., additional, Forsyth, C., additional, Ma, H. Z., additional, Goerigk, L., additional, O'Hair, R. A. J., additional, Bonnefont, A., additional, Ruhlmann, L., additional, Aloise, S., additional, and Ritchie, C., additional
- Published
- 2023
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23. Involving research participants in a pan-European research initiative: the EPAD participant panel experience
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Gregory, S., Bunnik, E. M., Callado, A. B., Carrie, I., De Boer, C., Duffus, J., Fauria, K., Forster, S., Gove, D., Knezevic, I., Laquidain, A., Pennetier, D., Saunders, S., Sparks, S., Rice, J., Ritchie, C. W., and Milne, R.
- Published
- 2020
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24. Residential and Recreational Acquisition of Possible Estuary-Associated Syndrome: A New Approach to Successful Diagnosis and Treatment
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Shoemaker, Ritchie C.
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- 2001
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25. Possible Estuary-Associated Symdrome: Symptoms, Vision, and Treatment
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Shoemaker, Ritchie C. and Hudnell, H. Kenneth
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- 2001
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26. Moldy Buildings, CIRS, Sick People, and Damaged Brains: 25 Years of Research Brought Us to the Cure Word, Part 5
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Shoemaker, Ritchie C., Lark, David, and Ryan, James C.
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Brain ,Brain damage ,Radiation (Physics) ,CAT scans ,Smallpox ,Diagnostic imaging ,Health - Abstract
Transcriptomics In the annals of medical history, there are advances that have changed both the art and science of the practice of medicine. A few we learned about in high [...]
- Published
- 2019
27. Moldy Buildings, CIRS, Sick People, and Damaged Brains: 25 Years of Research Brought Us to the Cure Word, Part 4
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Shoemaker, Ritchie C., Lark, David, and Ryan, James C.
- Subjects
Brain ,Melanocyte stimulating hormone ,Bile acids ,Brain damage ,Antibiotics ,Antibodies ,Hormones ,Deoxycholic acid ,Vasopressins ,Pituitary hormones ,Gluten ,Microbial drug resistance ,Health ,Welchol (Medication) - Abstract
The Treatment Steps Removal from exposure is the first step in treatment. This is followed by use of bile acid sequestrants, including cholestyramine or Welchol. Removal of biofilm-forming MARCoNS (multiple [...]
- Published
- 2019
28. Moldy Buildings, CIRS, Sick People, and Damaged Brains: 25 Years of Research Brought Us to the Cure Word, Part 3
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Shoemaker, Ritchie C., Lark, David, and Ryan, James C.
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Brain ,Methicillin ,Brain damage ,Genes ,Inflammation ,Proteomics ,Health - Abstract
CIRS Diagnosis When we think of chronic inflammatory response syndrome (CIRS) in 2019, our initial case definition has been expanded to include not only 1. abnormal proteomics; 2. abnormal regulation [...]
- Published
- 2019
29. Physical, Psychological, Social, and Existential Symptoms in Older Homeless-Experienced Adults: An Observational Study of the Hope Home Cohort
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Patanwala, M., Tieu, L., Ponath, C., Guzman, D., Ritchie, C. S., and Kushel, Margot
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- 2018
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30. A first update on mapping the human genetic architecture of COVID-19
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COVID-19 Host Genetics Initiative, Pathak, GA, Karjalainen, J, Stevens, C, Neale, BM, Daly, M, Ganna, A, Andrews, SJ, Kanai, M, Cordioli, M, Polimanti, R, Harerimana, N, Pirinen, M, Liao, RG, Chwialkowska, K, Trankiem, A, Balaconis, MK, Nguyen, H, Solomonson, M, Veerapen, K, Wolford, B, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Niemi, MEK, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Azarzar, S, Gofflot, S, Claassen, S, Malaise, O, Huynen, P, Meuris, C, Thys, M, Jacques, J, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Frenckell, CV, Belhaj, Y, Lambermont, B, Nakanishi, T, Morrison, DR, Mooser, V, Richards, JB, Butler-Laporte, G, Forgetta, V, Li, R, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chassé, M, Kaufmann, DE, Lathrop, GM, Adra, D, Hayward, C, Glessner, JT, Shaw, DM, Campbell, A, Morris, M, Hakonarson, H, Porteous, DJ, Below, J, Richmond, A, Chang, X, Polikowski, H, Lauren, PE, Chen, H-H, Wanying, Z, Fawns-Ritchie, C, North, K, McCormick, JB, Glessner, JR, Gignoux, CR, Wicks, SJ, Crooks, K, Barnes, KC, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Timmers, PRHJ, Wilson, JF, Tenesa, A, Kerr, SM, D’Mellow, K, Shahin, D, El-Sherbiny, YM, von Hohenstaufen, KA, Sobh, A, Eltoukhy, MM, Nkambul, L, Elhadidy, TA, Abd Elghafar, MS, El-Jawhari, JJ, Mohamed, AAS, Elnagdy, MH, Samir, A, Abdel-Aziz, M, Khafaga, WT, El-Lawaty, WM, Torky, MS, El-shanshory, MR, Yassen, AM, Hegazy, MAF, Okasha, K, Eid, MA, Moahmed, HS, Medina-Gomez, C, Ikram, MA, Uitterlinden, AG, Mägi, R, Milani, L, Metspalu, A, Laisk, T, Läll, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Batini, C, Tobin, MD, Venn, LD, Lee, PH, Shrine, N, Williams, AT, Guyatt, AL, John, C, Packer, RJ, Ali, A, Free, RC, Wang, X, Wain, LV, Hollox, EJ, Bee, CE, Adams, EL, Palotie, A, Ripatti, S, Ruotsalainen, S, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Kaunisto, M, Rivolta, C, Bochud, P-Y, Bibert, S, Boillat, N, Nussle, SG, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Friolet, R, Vollenweider, P, Pagani, JL, Oddo, M, zu Bentrup, FM, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, RM, Lannepoudenx, Y, Portopena, L, Bochud, PY, Desgranges, F, Filippidis, P, Guéry, B, Haefliger, D, Kampouri, EE, Manuel, O, Munting, A, Papadimitriou-Olivgeris, M, Regina, J, Rochat-Stettler, L, Suttels, V, Tadini, E, Tschopp, J, Van Singer, M, Viala, B, Boillat-Blanco, N, Brahier, T, Hügli, O, Meuwly, JY, Pantet, O, Gonseth Nussle, S, Bochud, M, D’Acremont, V, Estoppey Younes, S, Albrich, WC, Cerny, A, O’Mahony, L, von Mering, C, Frischknecht, M, Kleger, G-R., Filipovic, M, Kahlert, CR, Wozniak, H, Negro, TR, Pugin, J, Bouras, K, Knapp, C, Egger, T, Perret, A, Montillier, P, di Bartolomeo, C, Barda, B, de Cid, R, Carreras, A, Moreno, V, Kogevinas, M, Galván-Femenía, I, Blay, N, Farré, X, Sumoy, L, Cortés, B, Mercader, JM, Guindo-Martinez, M, Torrents, D, Garcia-Aymerich, J, Castaño-Vinyals, G, Dobaño, C, Gori, M, Renieri, A, Mari, F, Mondelli, MU, Castelli, F, Vaghi, M, Rusconi, S, Montagnani, F, Bargagli, E, Franchi, F, Mazzei, MA, Cantarini, L, Tacconi, D, Feri, M, Scala, R, Spargi, G, Nencioni, C, Bandini, M, Caldarelli, GP, Canaccini, A, Ognibene, A, D’Arminio Monforte, A, Girardis, M, Antinori, A, Francisci, D, 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Giuseppe, Castori, Marco, Aucella, Filippo, Biagio, Antonio Di, Masucci, Luca, Valente, Serafina, Mandalà, Marco, Zucchi, Patrizia, Giannattasio, Ferdinando, Coviello, Domenico A., Mussini, Cristina, Tavecchia, Luisa, Crotti, Lia, Rizzi, Marco, Rovere, Maria Teresa La, Sarzi-Braga, Simona, Bussotti, Maurizio, Ravaglia, Sabrina, Artuso, Rosangela, Perrella, Antonio, Romani, Davide, Bergomi, Paola, Catena, Emanuele, Vincenti, Antonella, Ferri, Claudio, Grassi, Davide, Pessina, Gloria, Tumbarello, Mario, Pietro, Massimo Di, Sabrina, Ravaglia, Luchi, Sauro, Furini, Simone, Dei, Simona, Benetti, Elisa, Picchiotti, Nicola, Sanarico, Maurizio, Ceri, Stefano, Pinoli, Pietro, Raimondi, Francesco, Biscarini, Filippo, Stella, Alessandra, Zguro, Kristina, Capitani, Katia, Tanfoni, Marco, Fallerini, Chiara, Daga, Sergio, Baldassarri, Margherita, Fava, Francesca, Frullanti, Elisa, Valentino, Floriana, Doddato, Gabriella, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Mencarelli, Maria Antonietta, Rizzo, Caterina Lo, Pinto, Anna Maria, Beligni, Giada, Tommasi, Andrea, Sarno, Laura Di, Palmieri, Maria, Carriero, Miriam Lucia, Alaverdian, Diana, Busani, Stefano, Bruno, Raffaele, Vecchia, Marco, Belli, Mary Ann, Mantovani, Stefania, Ludovisi, Serena, Quiros-Roldan, Eugenia, Antoni, Melania Degli, Zanella, Isabella, Siano, Matteo, Emiliozzi, Arianna, Fabbiani, Massimiliano, Rossetti, Barbara, Bergantini, Laura, D’Alessandro, Miriana, Cameli, Paolo, Bennett, David, Anedda, Federico, Marcantonio, Simona, Scolletta, Sabino, Guerrini, Susanna, Conticini, Edoardo, Frediani, Bruno, Spertilli, Chiara, Donati, Alice, Guidelli, Luca, Corridi, Marta, Croci, Leonardo, Piacentini, Paolo, Desanctis, Elena, Cappelli, Silvia, Verzuri, Agnese, Anemoli, Valentina, Pancrazzi, Alessandro, Lorubbio, Maria, Miraglia, Federica Gaia, Venturelli, Sophie, Cossarizza, Andrea, Vergori, Alessandra, Gabrieli, Arianna, Riva, Agostino, Paciosi, Francesco, 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Trivedi, Bhavi, Wright, John, Finer, Sarah, Akhtar, Shaheen, Anwar, Mohammad, Arciero, Elena, Ashraf, Samina, Breen, Gerome, Chung, Raymond, Curtis, Charles J., Chowdhury, Maharun, Colligan, Grainne, Deloukas, Pano, Durham, Ceri, Griffiths, Chri, Hurles, Matt, Hussain, Shapna, Islam, Kamrul, Khan, Ahsan, Khan, Amara, Lavery, Cath, Lee, Sang Hyuck, Lerner, Robin, MacArthur, Daniel, MacLaughlin, Bev, Martin, Hilary, Miah, Shefa, Newman, Bill, Safa, Nishat, Tahmasebi, Farah, Griffiths, Christopher J., Smith, Albert V., Boughton, Andrew P., Li, Kevin W., LeFaive, Jonathon, Annis, Aubrey, Niavarani, Ahmadreza, Aliannejad, Rasoul, Sharififard, Bahareh, Amirsavadkouhi, Ali, Naderpour, Zeinab, Tadi, Hengameh Ansari, Aleagha, Afshar Etemadi, Ahmadi, Saeideh, Moghaddam, Seyed Behrooz Mohseni, Adamsara, Alireza, Saeedi, Morteza, Abdollahi, Hamed, Hosseini, Abdolmajid, Chariyavilaskul, Pajaree, Jantarabenjakul, Watsamon, Hirankarn, Nattiya, Chamnanphon, Monpat, Suttichet, Thitima B., Shotelersuk, Vorasuk, Pongpanich, Monnat, Phokaew, Chureerat, Chetruengchai, Wanna, Putchareon, Opa, Torvorapanit, Pattama, Puthanakit, Thanyawee, Suchartlikitwong, Pintip, Nilaratanakul, Voraphoj, Sodsai, Pimpayao, Brumpton, Ben M., Hveem, Kristian, Willer, Cristen, Zhou, Wei, Rogne, Tormod, Solligard, Erik, Åsvold, Bjørn Olav, Franke, Lude, Boezen, Marike, Deelen, Patrick, Claringbould, Annique, Lopera, Esteban, Warmerdam, Robert, Vonk, Judith. M., van Blokland, Irene, Lanting, Pauline, Ori, Anil P. S., Feng, Yen-Chen Anne, Mercader, Josep, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Green, Robert C., Perez, Emma F., Zöllner, Sebastian, Wang, Jiongming, Beck, Andrew, Sloofman, Laura G., Ascolillo, Steven, Sebra, Robert P., Collins, Brett L., Levy, Te, Buxbaum, Joseph D., Sealfon, Stuart C., Jordan, Daniel M., Thompson, Ryan C., Gettler, Kyle, Chaudhary, Kumardeep, Belbin, Gillian M., Preuss, Michael, Hoggart, Clive, Choi, Sam, Underwood, Slayton J., Salib, Irene, Britvan, Bari, Keller, Katherine, Tang, Lara, Peruggia, Michael, Hiester, Liam L., Niblo, Kristi, Aksentijevich, Alexandra, Labkowsky, Alexander, Karp, Avromie, Zlatopolsky, Menachem, Zyndorf, Marissa, Charney, Alexander W., Beckmann, Noam D., Schadt, Eric E., Abul-Husn, Noura S., Cho, Judy H., Itan, Yuval, Kenny, Eimear E., Loos, Ruth J. F., Nadkarni, Girish N., Do, Ron, O’Reilly, Paul, Huckins, Laura M., Ferreira, Manuel A. R., Abecasis, Goncalo R., Leader, Joseph B., Cantor, Michael N., Justice, Anne E., Carey, Dave J., Chittoor, Geetha, Josyula, Navya Shilpa, Kosmicki, Jack A., Horowitz, Julie E., Baras, Ari, Gass, Matthew C., Yadav, Ashish, Mirshahi, Tooraj, Hottenga, Jouke Jan, Bartels, Meike, de geus, Eco E. J. C., Nivard, Michel M. G., Verma, Anurag, Ritchie, Marylyn D., Rader, Daniel, Li, Binglan, Verma, Shefali S., Lucas, Anastasia, Bradford, Yuki, Abedalthagafi, Malak, Alaamery, Manal, Alshareef, Abdulraheem, Sawaji, Mona, Massadeh, Salam, AlMalik, Abdulaziz, Alqahtani, Saleh, Baraka, Dona, Harthi, Fawz Al, Alsolm, Ebtehal, Safieh, Leen Abu, Alowayn, Albandary M., Alqubaishi, Fatimah, Mutairi, Amal Al, Mangul, Serghei, Almutairi, Mansour, Aljawini, Nora, Albesher, Nour, Arabi, Yaseen M., Mahmoud, Ebrahim S., Khattab, Amin K., Halawani, Roaa T., Alahmadey, Ziab Z., Albakri, Jehad K., Felemban, Walaa A., Suliman, Bandar A., Hasanato, Rana, Al-Awdah, Laila, Alghamdi, Jahad, AlZahrani, Deema, AlJohani, Sameera, Al-Afghani, Hani, AlDhawi, Nouf, AlBardis, Hadeel, Alkwai, Sarah, Alswailm, Moneera, Almalki, Faisal, Albeladi, Maha, Almohammed, Iman, Barhoush, Eman, Albader, Anoud, Alotaibi, Sara, Alghamdi, Bader, Jung, Junghyun, fawzy, Mohammad S., Alrashed, May, Zeberg, Hugo, Nkambul, Lindo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklo, Tardif, Nicola, Rooyackers, Olav, Grip, Jonathan, Maricic, Tomislav, Helgeland, Øyvind, Magnus, Per, Trogstad, Lill-Iren S., Lee, Yunsung, Harris, Jennifer R., Mangino, Massimo, Spector, Tim D., Emma, Duncan, Moutsianas, Louka, Caulfield, Mark J., Scott, Richard H., Kousathanas, Athanasio, Pasko, Dorota, Walker, Susan, Stuckey, Alex, Odhams, Christopher A., Rhodes, Daniel, Fowler, Tom, Rendon, Augusto, Chan, Georgia, Arumugam, Prabhu, Karczewski, Konrad J., Martin, Alicia R., Wilson, Daniel J., Spencer, Chris C. A., Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikola, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline I., King, Daniel, Seed, Cotton, Daly, Mark J., Finucane, Hilary, Bryant, Sam, Satterstrom, F. Kyle, Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicola, Koelling, Nil, Armstrong, Jacob, Rudkin, Justine K., Callier, Shawneequa, Cusick, Caroline, Soranzo, Nicole, Zhao, Jing Hua, Danesh, John, Angelantonio, Emanuele Di, Butterworth, Adam S., Sun, Yan V., Huffman, Jennifer E., Cho, Kelly, O’Donnell, Christopher J., Tsao, Phil, Gaziano, J. Michael, Peloso, Gina, Ho, Yuk-Lam, Smieszek, Sandra P., Polymeropoulos, Christo, Polymeropoulos, Vasilio, Polymeropoulos, Mihael H., Przychodzen, Bartlomiej P., Fernandez-Cadenas, Israel, Planas, Anna M., Perez-Tur, Jordi, Llucià-Carol, Laia, Cullell, Natalia, Muiño, Elena, Cárcel-Márquez, Jara, DeDiego, Marta L., Iglesias, Lara Lloret, Soriano, Alex, Rico, Veronica, Agüero, Daiana, Bedini, Josep L., Lozano, Francisco, Domingo, Carlo, Robles, Veronica, Ruiz-Jaén, Francisca, Márquez, Leonardo, Gomez, Juan, Coto, Eliecer, Albaiceta, Guillermo M., García-Clemente, Marta, Dalmau, David, Arranz, Maria J., Dietl, Beatriz, Serra-Llovich, Alex, Soler, Pere, Colobrán, Roger, Martín-Nalda, Andrea, Martínez, Alba Parra, Bernardo, David, Rojo, Silvia, Fiz-López, Aida, Arribas, Elisa, de la Cal-Sabater, Paloma, Segura, Tomá, González-Villa, Esther, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Jiménez-Xarrié, Elena, de Felipe Mimbrera, Alicia, Masjuan, Jaime, García-Madrona, Sebastian, Domínguez-Mayoral, Anna, Villalonga, Joan Montaner, Menéndez-Valladares, Paloma, Chasman, Daniel I., Sesso, Howard D., Manson, JoAnn E., Buring, Julie E., Ridker, Paul M., Franco, Giulianini, Davis, Lea, Lee, Sulggi, Priest, Jame, Sankaran, Vijay G., van Heel, David, Biesecker, Le, Kerchberger, V. Eric, Baillie, J. Kenneth, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Biological Psychology, APH - Mental Health, AMS - Sports, AMS - Ageing & Vitality, APH - Methodology, Mccurdy, Shannon, Mccormick, Joseph B., Macarthur, Daniel, Maclaughlin, Bev, Lefaive, Jonathon, Almalik, Abdulaziz, Alzahrani, Deema, Aljohani, Sameera, Aldhawi, Nouf, Albardis, Hadeel, Fawzy, Mohammad S., Dediego, Marta L., Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), University of Zurich, COVID-19 Host Genetics Initiative, Barcelona Supercomputing Center, COVID-19 Genetics Initiative, including authors, Institute for Molecular Medicine Finland, and Data Science Genetic Epidemiology Lab
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Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC] ,Quantitative Trait Loci ,MUC5B PROMOTER POLYMORPHISM ,Genome-wide association studies ,COVID-19 (Malaltia) ,UFSP13-7 Evolution in Action: From Genomes to Ecosystems ,COVID-19 (Disease) ,Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA ,SDG 3 - Good Health and Well-being ,Humans ,genetics ,Genetic variation ,Genomes ,Medicinsk genetik ,1000 Multidisciplinary ,Multidisciplinary ,Chromosome Mapping ,COVID-19 ,Human Genetics ,10124 Institute of Molecular Life Sciences ,covid-19 ,3121 General medicine, internal medicine and other clinical medicine ,570 Life sciences ,biology ,Medical Genetics - Abstract
Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-x The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity. Here we present meta-analyses bringing together 60 studies from 25 countries (Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals); (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals); and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1. We found a total of 23 genome-wide significant loci (P
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31. Whole-genome sequencing reveals host factors underlying critical COVID-19
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P., Vitart V., Yang J., Bretherick A. D., Hendry S. C., Law A., and Baillie J. K.
- Abstract
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease.
- Published
- 2022
32. Ciguatera: A Treating Physician's Perspective on a Global Illness
- Author
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Shoemaker, Ritchie C., primary and Ryan, James C., additional
- Published
- 2018
- Full Text
- View/download PDF
33. Inflammatory Responses Acquired Following Environmental Exposures Are Involved in Pathogenesis of Musculoskeletal Pain
- Author
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Shoemaker, Ritchie C., primary and Ryan, James C., additional
- Published
- 2018
- Full Text
- View/download PDF
34. Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study.
- Author
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Shannon, OM, Ranson, JM, Gregory, S, Macpherson, H, Milte, C, Lentjes, M, Mulligan, A, McEvoy, C, Griffiths, A, Matu, J, Hill, TR, Adamson, A, Siervo, M, Minihane, AM, Muniz-Tererra, G, Ritchie, C, Mathers, JC, Llewellyn, DJ, Stevenson, E, Shannon, OM, Ranson, JM, Gregory, S, Macpherson, H, Milte, C, Lentjes, M, Mulligan, A, McEvoy, C, Griffiths, A, Matu, J, Hill, TR, Adamson, A, Siervo, M, Minihane, AM, Muniz-Tererra, G, Ritchie, C, Mathers, JC, Llewellyn, DJ, and Stevenson, E
- Abstract
BACKGROUND: The identification of effective dementia prevention strategies is a major public health priority, due to the enormous and growing societal cost of this condition. Consumption of a Mediterranean diet (MedDiet) has been proposed to reduce dementia risk. However, current evidence is inconclusive and is typically derived from small cohorts with limited dementia cases. Additionally, few studies have explored the interaction between diet and genetic risk of dementia. METHODS: We used Cox proportional hazard regression models to explore the associations between MedDiet adherence, defined using two different scores (Mediterranean Diet Adherence Screener [MEDAS] continuous and Mediterranean diet Pyramid [PYRAMID] scores), and incident all-cause dementia risk in 60,298 participants from UK Biobank, followed for an average 9.1 years. The interaction between diet and polygenic risk for dementia was also tested. RESULTS: Higher MedDiet adherence was associated with lower dementia risk (MEDAS continuous: HR = 0.77, 95% CI = 0.65-0.91; PYRAMID: HR = 0.86, 95% CI = 0.73-1.02 for highest versus lowest tertiles). There was no significant interaction between MedDiet adherence defined by the MEDAS continuous and PYRAMID scores and polygenic risk for dementia. CONCLUSIONS: Higher adherence to a MedDiet was associated with lower dementia risk, independent of genetic risk, underlining the importance of diet in dementia prevention interventions.
- Published
- 2023
35. Abstract No. 82 Lung Shunt Fraction in 90Y Radiation Segmentectomy: Is Technetium-99m Macroaggregated Albumin (99mTc-MAA) Scan Necessary?
- Author
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Montazeri, A., primary, De La Garza Ramos, C., additional, Paz-Fumagalli, R., additional, Lewis, A., additional, Devcic, Z., additional, Frey, G., additional, Ritchie, C., additional, McKinney, J., additional, and Toskich, B., additional
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- 2023
- Full Text
- View/download PDF
36. Structural brain abnormalities in patients with inflammatory illness acquired following exposure to water-damaged buildings: A volumetric MRI study using NeuroQuant®
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Shoemaker, Ritchie C., House, Dennis, and Ryan, James C.
- Published
- 2014
- Full Text
- View/download PDF
37. Visual Contrast Sensitivity: Response
- Author
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Hudnell, H. Kenneth and Shoemaker, Ritchie C.
- Published
- 2002
38. PCR294 Assessment of Health State Utilities Associated With Being a Caregiver for a Person With Alzheimer's Disease With Mild Cognitive Impairment or Dementia
- Author
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Matza, L.S., Howell, T.A., Belger, M., Ritchie, C., Delio, P.R., Johnston, J.A., and Tockhorn-Heidenreich, A.
- Published
- 2024
- Full Text
- View/download PDF
39. Moldy Buildings, CIRS, Sick People, and Damaged Brains: 25 Years of Research Brought Us to the Cure Word, Part 2
- Author
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Shoemaker, Ritchie C., Lark, David, and Ryan, James C.
- Subjects
Brain ,Brain damage ,Water ,Editors ,Health - Abstract
Editor's Note: Exposure to mold in water-damaged buildings causes a frustrating number of puzzling symptoms and eventually leads to chronic inflammatory response syndrome (CIRS), as explained in the first article of this five-part series, published in the July 2019 issue. In Part 2, the authors explain the importance of maintaining the building envelope in order to prevent health-damaging mold from infesting buildings. This is the first step in prevention... and in healing., How Does Water Get Inside? ROOFS: Have you ever put on a new roof or watched someone else do the work? How many thousand nails are required to shingle a [...]
- Published
- 2019
40. Moldy Buildings, CIRS, Sick People, and Damaged Brains, Part 1: Living in a Water-Damaged Building
- Author
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Shoemaker, Ritchie C., Lark, David, and Ryan, James C.
- Subjects
Brain damage ,Bacteria ,Education ,Leases ,Health - Abstract
Imagine being trapped by your home, workplace or school. You can see the mold, smell the bacteria. You are living in a microbial dungeon. Deep down, you know the building [...]
- Published
- 2019
41. Whole genome sequencing reveals host factors underlying critical Covid-19
- Author
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Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., Zechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Mcauley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J., Baillie, J. K., Begg, C., Ling, L., Pereira, A. C., Aravindan, L., Armstrong, R., Biggs, H., Boz, C., Brown, A., Clark, R., Coutts, A., Coyle, J., Cullum, L., Das, S., Day, N., Donnelly, L., Duncan, E., Finernan, P., Fourman, M. H., Furlong, A., Furniss, J., Gallagher, B., Gilchrist, T., Golightly, A., Hafezi, K., Hamilton, D., Hendry, R., Law, D., Law, R., Law, S., Lidstone-Scott, R., Macgillivray, L., Maclean, A., Mal, H., Mccafferty, S., Mcmaster, E., Meikle, J., Moore, S. C., Murphy, S., Hellen, M., Zheng, C., Chen, J., Paterson, T., Schon, K., Stenhouse, A., Das, M., Swets, M., Szoor-McElhinney, H., Taneski, F., Turtle, L., Wackett, T., Ward, M., Weaver, J., Wrobel, N., Arbane, G., Bociek, A., Campos, S., Grau, N., Jones, T. 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S., Templeton, M., Meredith, M., Morris, L., Ryan, L., Clark, A., Sampson, J., Peters, C., Dent, M., Langley, M., Ashraf, Sana, Wei, S., Andrew, A., Bashyal, A., Davidson, N., Hutton, P., Mckechnie, S., Wilson, J., Baptista, D., Crowe, R., Fernandes, R., Herdman-Grant, R., Joseph, A., O'Connor, D., Allen, M., Loveridge, A., Mckenley, I., Morino, E., Naranjo, A., Simms, R., Sollesta, K., Swain, A., Venkatesh, H., Khera, J., Fox, J., Andrew, G., Barclay, L., Callaghan, M., Campbell, R., Clark, S., Hope, D., Marshall, L., Mcculloch, C., Briton, K., Singleton, J., Birch, S., Brimfield, L., Daly, Z., Pogson, D., Rose, S., Nown, A., Battle, C., Brinkworth, E., Harford, R., Murphy, C., Newey, L., Rees, T., Williams, M., Arnold, S., Polgarova, P., Stroud, K., Meaney, E., Jones, M., Ng, A., Agrawal, S., Pathan, N., White, D., Daubney, E., Elston, K., Grauslyte, L., Hussain, M., Phull, M., Pogreban, T., Rosaroso, L., Salciute, E., Franke, G., Wong, J., George, A., de Gordoa, L. 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K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Bochud, P, Rivolta, C, Bibert, S, Quinodoz, M, Kamdar, D, Boillat, N, Nussle, S, Albrich, W, Suh, N, Neofytos, D, Erard, V, Voide, C, de Cid, R, Galvan-Femenia, I, Blay, N, Carreras, A, Cortes, B, Farre, X, Sumoy, L, Moreno, V, Mercader, J, Guindo-Martinez, M, Torrents, D, Kogevinas, M, Garcia-Aymerich, J, Castano-Vinyals, G, Dobano, C, Renieri, A, Mari, F, Fallerini, C, Daga, S, Benetti, E, Baldassarri, M, Fava, F, Frullanti, E, Valentino, F, Doddato, G, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Mencarelli, M, Rizzo, C, Pinto, A, Beligni, G, Tommasi, A, Di Sarno, L, Palmieri, M, Carriero, M, Alaverdian, D, Busani, S, Bruno, R, Vecchia, M, Belli, M, Picchiotti, N, Sanarico, M, Gori, M, Furini, S, Mantovani, S, Ludovisi, S, Mondelli, M, Castelli, F, Quiros-Roldan, E, Antoni, M, Zanella, I, Vaghi, M, Rusconi, S, Siano, M, Montagnani, F, Emiliozzi, A, Fabbiani, M, Rossetti, B, Bargagli, E, Bergantini, L, D'Alessandro, M, Cameli, P, Bennett, D, Anedda, F, Marcantonio, S, Scolletta, S, Franchi, F, Mazzei, M, Guerrini, S, Conticini, E, Cantarini, L, Frediani, B, Tacconi, D, Spertilli, C, Feri, M, Donati, A, Scala, R, Guidelli, L, Spargi, G, Corridi, M, Nencioni, C, Croci, L, Bandini, M, Caldarelli, G, Piacentini, P, Desanctis, E, Cappelli, S, Canaccini, A, Verzuri, A, Anemoli, V, Ognibene, A, Pancrazzi, A, Lorubbio, M, D'Arminio Monforte, A, Miraglia, F, Girardis, M, Venturelli, S, Cossarizza, A, Antinori, A, Vergori, A, Gabrieli, A, Riva, A, Francisci, D, Schiaroli, E, Paciosi, F, Scotton, P, Andretta, F, Panese, S, Scaggiante, R, Gatti, F, Parisi, S, Baratti, S, Della Monica, M, Piscopo, C, Capasso, M, Russo, R, Andolfo, I, Iolascon, A, Fiorentino, G, Carella, M, Castori, M, Merla, G, Squeo, G, Aucella, F, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Di Biagio, A, Sanguinetti, M, Masucci, L, Valente, S, Mandala, M, Giorli, A, Salerni, L, Zucchi, P, Parravicini, P, Menatti, E, Trotta, T, Giannattasio, F, Coiro, G, Lena, F, Coviello, D, Mussini, C, Martinelli, E, Mancarella, S, Tavecchia, L, Crotti, L, Gabbi, C, Rizzi, M, Maggiolo, F, Ripamonti, D, Bachetti, T, La Rovere, M, Sarzi-Braga, S, Bussotti, M, Ceri, S, Pinoli, P, Raimondi, F, Biscarini, F, Stella, A, Zguro, K, Capitani, K, Suardi, C, Dei, S, Parati, G, Ravaglia, S, Artuso, R, Botta, G, Di Domenico, P, Rancan, I, Perrella, A, Bianchi, F, Romani, D, Bergomi, P, Catena, E, Colombo, R, Tanfoni, M, Vincenti, A, Ferri, C, Grassi, D, Pessina, G, Tumbarello, M, Di Pietro, M, Sabrina, R, Luchi, S, Barbieri, C, Acquilini, D, Andreucci, E, Segala, F, Tiseo, G, Falcone, M, Lista, M, Poscente, M, De Vivo, O, Petrocelli, P, Guarnaccia, A, Baroni, S, Smith, A, Boughton, A, Li, K, Lefaive, J, Annis, A, Chittoor, G, Josyula, N, Leader, J, Carey, D, Gass, M, Cantor, M, Yadav, A, van Heel, D, Hunt, K, Mason, D, Huang, Q, Finer, S, Trivedi, B, Griffiths, C, Martin, H, Wright, J, Trembath, R, Soranzo, N, Zhao, J, Butterworth, A, Danesh, J, Di Angelantonio, E, Franke, L, Boezen, M, Deelen, P, Claringbould, A, Lopera, E, Warmerdam, R, Vonk, J, van Blokland, I, Lanting, P, Ori, A, Zollner, S, Wang, J, Beck, A, Peloso, G, Ho, Y, Sun, Y, Huffman, J, O'Donnell, C, Cho, K, Tsao, P, Gaziano, J, Nivard, M, de Geus, E, Bartels, M, Jan Hottenga, J, Weiss, S, Karlson, E, Smoller, J, Green, R, Feng, Y, Murphy, S, Meigs, J, Woolley, A, Perez, E, Li, B, Verma, S, Lucas, A, Bradford, Y, Zeberg, H, Frithiof, R, Hultstrom, M, Lipcsey, M, Tardif, N, Rooyackers, O, Grip, J, Maricic, T, Karczewski, K, Atkinson, E, Tsuo, K, Baya, N, Turley, P, Gupta, R, Callier, S, Walters, R, Palmer, D, Sarma, G, Cheng, N, Lu, W, Bryant, S, Churchhouse, C, Cusick, C, Goldstein, J, King, D, Seed, C, Finucane, H, Martin, A, Satterstrom, F, Wilson, D, Armstrong, J, Rudkin, J, Band, G, Earle, S, Lin, S, Arning, N, Crook, D, Wyllie, D, O'Connell, A, Spencer, C, Koelling, N, Caulfield, M, Scott, R, Moutsianas, L, Pasko, D, Ball, C, Hong, E, Rand, K, Girshick, A, Guturu, H, Baltzell, A, Roberts, G, Park, D, Coignet, M, Mccurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Sloofman, L, Charney, A, Beckmann, N, Schadt, E, Jordan, D, Thompson, R, Gettler, K, Abul-Husn, N, Ascolillo, S, Buxbaum, J, Chaudhary, K, Cho, J, Itan, Y, Kenny, E, Belbin, G, Sealfon, S, Sebra, R, Salib, I, Collins, B, Levy, T, Britvan, B, Keller, K, Tang, L, Peruggia, M, Hiester, L, Niblo, K, Aksentijevich, A, Labkowsky, A, Karp, A, Zlatopolsky, M, Preuss, M, Loos, R, Nadkarni, G, Do, R, Hoggart, C, Choi, S, Underwood, S, O'Reilly, P, Huckins, L, Zyndorf, M, Daly, M, Neale, B, Ganna, A, Fawkes, A, Murphy, L, Rowan, K, Ponting, C, Vitart, V, Yang, J, Bretherick, A, Hendry, S, Law, A, Baillie, J, Kousathanas, Athanasios [0000-0001-6265-6521], Pairo-Castineira, Erola [0000-0002-2423-3090], Rawlik, Konrad [0000-0002-0010-370X], Walker, Susan [0000-0002-5016-6426], Malinauskas, Tomas [0000-0002-4847-5529], Wu, Yang [0000-0002-0128-7280], Shen, Xia [0000-0003-4390-1979], Elliott, Katherine S [0000-0002-8125-797X], Keating, Sean [0000-0001-8552-5604], Wang, Bo [0000-0002-1580-797X], Klaric, Lucija [0000-0003-3105-8929], Parkinson, Nick [0000-0001-6336-5654], Nichol, Alistair [0000-0002-4689-1238], Semple, Malcolm G [0000-0001-9700-0418], Salehi, Shahla [0000-0002-5058-7706], Knight, Julian [0000-0002-0377-5536], Elgar, Greg [0000-0001-7323-1596], Patch, Christine [0000-0002-4191-0663], Baras, Aris [0000-0002-6830-3396], Abecasis, Goncalo R [0000-0003-1509-1825], Ferreira, Manuel AR [0000-0001-9059-1825], Rader, Daniel J [0000-0002-9245-9876], Ritchie, Marylyn D [0000-0002-1208-1720], Shankar-Hari, Manu [0000-0002-5338-2538], Summers, Charlotte [0000-0002-7269-2873], Hinds, Charles [0000-0001-5094-8324], McAuley, Danny [0000-0002-3283-1947], Montgomery, Hugh [0000-0001-8797-5019], Elliott, Paul [0000-0002-7511-5684], Tenesa, Albert [0000-0003-4884-4475], Murphy, Lee [0000-0001-6467-7449], Rowan, Kathy [0000-0001-8217-5602], Ponting, Chris P [0000-0003-0202-7816], Vitart, Veronique [0000-0002-4991-3797], Wilson, James F [0000-0001-5751-9178], Yang, Jian [0000-0003-2001-2474], Bretherick, Andrew D [0000-0001-9258-3140], Hendry, Sara Clohisey [0000-0001-7489-9846], Moutsianas, Loukas [0000-0001-5453-345X], Law, Andy [0000-0003-1868-2364], Caulfield, Mark J [0000-0001-9295-3594], Baillie, J Kenneth [0000-0001-5258-793X], Apollo - University of Cambridge Repository, National Institute for Health Research, UKRI MRC COVID-19 Rapid Response Call, UK Research and Innovation, Internal Medicine, Epidemiology, Center of Experimental and Molecular Medicine, AII - Infectious diseases, Amsterdam Neuroscience - Neuroinfection & -inflammation, Neurology, Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), APH - Methodology, APH - Mental Health, Biological Psychology, AMS - Ageing & Vitality, AMS - Sports, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Department of Health & Social Care (UK), Medical Research Council (UK), Roslin Institute, Pérez-Tur, Jordi, Institute for Molecular Medicine Finland, Doctoral Programme in Population Health, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, Department of Public Health, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Faculty Common Matters (Faculty of Social Sciences), Data Science Genetic Epidemiology Lab, CAMM - Research Program for Clinical and Molecular Metabolism, investigators, GenOMICC, investigators, 23andMe, and Initiative, COVID-19 Human Genetics
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Genome-wide association studies ,PATHWAY ,Fucosyltransferase ,Lectins ,Receptors ,Genetics research ,TOOL ,Phospholipid Transfer Proteins ,Genome ,Multidisciplinary ,C-Type ,ATP-Binding Cassette Transporters ,Cell Adhesion Molecules ,Critical Care ,E-Selectin ,Factor VIII ,Fucosyltransferases ,Genome-Wide Association Study ,Humans ,Interleukin-10 Receptor beta Subunit ,Lectins, C-Type ,Mucin-1 ,Nerve Tissue Proteins ,Receptors, Cell Surface ,Repressor Proteins ,SARS-CoV-2 ,COVID-19 ,Critical Illness ,Genome, Human ,Host-Pathogen Interactions ,Whole Genome Sequencing ,1184 Genetics, developmental biology, physiology ,ASSOCIATION ,GenOMICC investigators ,COVID-19/genetics ,Host-Pathogen Interactions/genetics ,Multidisciplinary Sciences ,Host-Pathogen Interaction ,Cell Surface ,Science & Technology - Other Topics ,Infectious diseases ,Critical Illne ,Human ,Respiratory distress syndrome ,General Science & Technology ,ATP-Binding Cassette Transporter ,DENDRITIC CELLS ,23andMe investigators ,Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA ,Phospholipid Transfer Protein ,SDG 3 - Good Health and Well-being ,LINKAGE ,Science & Technology ,SARS-CoV-2/pathogenicity ,Repressor Protein ,SIGNAL ,ONTOLOGY ,COVID-19 Human Genetics Initiative ,Critical Illness/mortality ,Cell Adhesion Molecule ,Nerve Tissue Protein ,Genome, Human/genetics - Abstract
34 páginas, 3 figuras, 1 tabla., Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease., GenOMICC was funded by the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council (MRC), UKRI, Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (J.K.B., 223164/Z/21/Z) a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_ PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. WGS was performed by Illumina Article at Illumina Laboratory Services and was overseen by Genomics England. We would like to thank all at Genomics England who have contributed to the sequencing, clinical and genomic data analysis. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant ref. MC_PC_20029). A.D.B. would like to acknowledge funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z) and the Edinburgh Clinical Academic Track (ECAT) programme. We thank the research participants and employees of 23andMe for making this work possible. Genomics England and the 100,000 Genomes Project were funded by the National Institute for Health Research, the Wellcome Trust, the MRC, Cancer Research UK, the DHSC and NHS England. We are grateful for the support from S. Hill and the team in NHS England and the 13 Genomic Medicine Centres that delivered the 100,000 Genomes Project, which provided most of the control genome sequences for this study. We thank the participants in the 100,000 Genomes Project, who made this study possible, and the Genomics England Participant Panel for their strategic advice, involvement and engagement. We acknowledge NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre, who provided life-course longitudinal clinical data on the participants. This work forms part of the portfolio of research of the National Institute for Health Research Barts Biomedical Research Centre. Mark Caulfield is an NIHR Senior Investigator. This study owes a great deal to the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. Additional replication was conducted using the UK Biobank Resource (project 26041). The Penn Medicine BioBank is funded by a gift from the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health under CTSA award number UL1TR001878; and the Perelman School of Medicine at the University of Pennsylvania. We thank the AncestryDNA customers who voluntarily contributed information in the COVID-19 survey. HRS (dbGaP accession: phs000428.v1.p1): HRS was supported by the National Institute on Aging (NIA U01AG009740). The genotyping was funded separately by the National Institute on Aging (RC2 AG036495, RC4 AG039029). Genotyping was conducted by the NIH Center for Inherited Disease Research (CIDR) at Johns Hopkins University. Genotyping quality control and final preparation of the data were performed by the Genetics Coordinating Center at the University of Washington. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by the NCI, NHGRI, NHLBI, NIDA, NIMH and NINDS. The data used for the analyses described in this manuscript were obtained from the GTEx Portal on 22 August 2021 (GTEx Analysis Release v.8 (dbGaP Accession phs000424.v8.p2). We thank the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available at https://www.covid19hg.org/acknowledgements. The views expressed are those of the authors and not necessarily those of the DHSC, NHS, Department for International Development (DID), NIHR, MRC, Wellcome Trust or Public Health England.
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- 2022
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42. Comprehensive geriatric assessment in the emergency department
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Ellis G, Marshall T, and Ritchie C
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Geriatric ,Frailty ,Emergency Department ,Assessment ,Geriatrics ,RC952-954.6 - Abstract
Graham Ellis,1 Trudi Marshall,2 Claire Ritchie2 1Medicine for the Elderly, Monklands Hospital, Airdrie, Scotland, UK; 2Kirklands Hospital, Bothwell, Scotland, UK Abstract: Changing global demography is resulting in older people presenting to emergency departments (EDs) in greater numbers than ever before. They present with greater urgency and are more likely to be admitted to hospital or re-attend and utilize greater resources. They experience longer waits for care and are less likely to be satisfied with their experiences. Not only that, but older people suffer poorer health outcomes after ED attendance, with higher mortality rates and greater dependence in activities of daily living or rates of admission to nursing homes. Older people’s assessment and management in the ED can be complex, time consuming, and require specialist skills. The interplay of multiple comorbidities and functional decline result in the complex state of frailty that can predispose to poor health outcomes and greater care needs. Older people with frailty may present to services in an atypical fashion requiring detailed, multidimensional, and increasingly multidisciplinary care to provide the correct diagnosis and management as well as appropriate placement for ongoing care or admission avoidance. Specific challenges such as delirium, functional decline, or carer strain need to be screened for and managed appropriately. Identifying patients with specific frailty syndromes can be critical to identifying those at highest risk of poor outcomes and most likely to benefit from further specialist interventions. Models of care are evolving that aim to deliver multidimensional assessment and management by multidisciplinary specialist care teams (comprehensive geriatric assessment). Increasingly, these models are demonstrating improved outcomes, including admission avoidance or reduced death and dependence. Delivering this in the ED is an evolving area of practice that adapts the principles of geriatric medicine for the urgent-care environment. Keywords: ED, frailty, models of care
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- 2014
43. Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility
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van Blokland, I, Lanting, P, Ori, A, Vonk, J, Warmerdam, R, Herkert, J, Boulogne, F, Claringbould, A, Lopera-Maya, E, Bartels, M, Hottenga, J, Ganna, A, Karjalainen, J, Hayward, C, Fawns-Ritchie, C, Campbell, A, Porteous, D, Cirulli, E, Barrett, K, Riffle, S, Bolze, A, White, S, Tanudjaja, F, Wang, X, Ramirez, J, Lim, Y, Lu, J, Washington, N, de Geus, E, Deelen, P, Boezen, H, Franke, L, Mierau, J, Dekens, J, Nolte, I, Dijkema, M, Wiersma, H, Jankipersadsing, S, Cho, J, Loos, R, Moscati, A, Chang, Y, Choe, P, Chung, J, Ham, S, Joo, E, Jung, J, Kang, C, Kim, H, Kim, E, Lee, H, Park, S, Park, K, Park, J, Ryu, S, Song, K, Paik, N, Albillos, A, Asselta, R, Bujanda, L, Buti, M, Duga, S, Fernandez, J, Gomez, M, Invernizzi, P, Prati, D, Banales, J, Folseraas, T, Franke, A, Hov, J, Karlsen, T, Valenti, L, Degenhardt, F, Ellighaus, D, Eythorsson, E, Haraldsson, A, Helgason, D, Holm, H, Ingvarsson, R, Jonsdottir, I, Norddahl, G, Palsson, R, Saemundsdottir, J, Stefansson, K, Thorsteinsdottir, U, Gudbjartsson, D, Jonsson, H, Melsted, P, Sulem, P, Sveinbjornsson, G, Alarcon-Riquelme, M, Bernardo, D, Rello, S, Martinez-Bueno, M, Amtrano, S, Bruttini, M, Floriana, V, Giliberti, A, Benetti, E, Fallerini, C, Furini, S, Pinto, A, Baldassarri, M, Fava, F, Mari, F, Renieri, A, Croci, S, Tita, R, Frullanti, E, Altshul, D, Huang, Q, Hunt, K, Martin, H, Mason, D, Trembath, R, Trivedi, B, Wright, J, Finer, S, Griffiths, C, van Heel, D, Jannes, C, Krieger, J, Pereira, A, Marques, E, Dalton, K, Deboever, C, Jimenez-Morales, D, Palomera, A, Pinsky, B, Smith, E, Szalma, S, Tralau-Stewart, C, Wong, E, Gorzynski, J, de Jong, H, Amar, D, Delaneau, O, Hughes, C, Ioannidis, A, Raja, A, Rubinacci, S, Tanigawa, Y, Ashley, E, Bustamante, C, Parikh, V, Rivas, M, Wheeler, M, Busson, A, Goffard, J, Migeotte, I, Peyrassol, X, Smits, G, Vandernoot, I, Wilkin, F, Bouysran, Y, Pichon, B, Tiembe, N, Green, R, Karlson, B, Meigs, J, Mercader, J, Murphy, S, Perez, E, Slaugenhaupt, S, Smoller, J, Weiss, S, Woolley, A, Feng, Y, Nivard, M, Brusco, A, Bulik, C, Franchimont, D, Landen, M, Louis, E, Pedersen, N, Rahmouni, S, Striano, P, Vermeire, S, Zara, F, Al-Muftah, W, Badji, R, Ismail, S, Al-Sarraj, Y, Mbarek, H, Arumugam, P, Caulfield, M, Need, A, Oscroft, T, Rendon, A, Scott, R, Chan, G, Kousathanas, A, Moutsianas, L, Odhams, C, Pasko, D, Rhodes, D, Stuckey, A, Atkinson, E, Baya, N, Butler-Laporte, G, Finucane, H, Forgetta, V, Kanai, M, Karczewski, K, Koelling, N, Martin, A, Nakanishi, T, Palmer, D, Richards, J, Spencer, C, Turley, P, Walters, R, Wilson, D, Armstrong, J, O'Connell, A, Wyllie, D, Bryant, S, Churchhouse, C, Di Angelantonio, E, Chapman, M, Danesh, J, Ouwehand, W, Roberts, D, Watkins, N, Butterworth, A, Zhao, J, Biesecker, L, Davis, L, Kerchberger, E, Lee, S, Priest, J, Richards, B, Sankaran, V, Chwialkowska, K, Francescatto, M, Stevens, C, Trankiem, A, Balaconis, K, Liao, R, Daly, M, Neale, B, Bernasconi, A, Ceri, S, Cordioli, M, Niemi, M, Zhou, W, Nguyen, H, Solomonson, M, Gopalan, S, Hou, K, Jansen, P, de Leeuw, C, Lu, Z, Mancuso, N, Marouli, E, Papadopoulou, A, Pasaniuc, B, Pathak, G, Polimanti, R, Posthuma, D, Savage, J, Uffelmann, E, Visscher, P, Wendt, F, Wray, N, Yengo, L, van Blokland I. V., Lanting P., Ori A. P. S., Vonk J. M., Warmerdam R. C. A., Herkert J. C., Boulogne F., Claringbould A., Lopera-Maya E. A., Bartels M., Hottenga J. -J., Ganna A., Karjalainen J., Hayward C., Fawns-Ritchie C., Campbell A., Porteous D., Cirulli E. T., Barrett K. M. S., Riffle S., Bolze A., White S., Tanudjaja F., Wang X., Ramirez J. M., Lim Y. W., Lu J. T., Washington N. L., de Geus E. J. C., Deelen P., Boezen H. M., Franke L. H., Mierau J. O., Dekens J., Nolte I., Dijkema M. X. L., Wiersma H. H., Jankipersadsing S. A., Cho J. H., Loos R. J. F., Moscati A., Chang Y., Choe P. G., Chung J., Ham S., Joo E. -J., Jung J., Kang C. K., Kim H. -L., Kim H. B., Kim E. S., Lee H. -J., Park S., Park K. -U., Park J. S., Ryu S., Song K. -H., Kim H. -N., Paik N. -J., Albillos A., Asselta R., Bujanda L., Buti M., Duga S., Fernandez J., Gomez M. R., Invernizzi P., Prati D., Banales J. M., Folseraas T., Franke A., Hov J. R., Karlsen T. H., Valenti L., Degenhardt F., Ellighaus D., Eythorsson E. S., Haraldsson A., Helgason D., Holm H., Ingvarsson R. F., Jonsdottir I., Norddahl G. L., Palsson R., Saemundsdottir J., Stefansson K., Thorsteinsdottir U., Gudbjartsson D. F., Jonsson H., Melsted P., Sulem P., Sveinbjornsson G., Alarcon-Riquelme M. E., Bernardo D., Rello S. R., Martinez-Bueno M., Amtrano S., Bruttini M., Floriana V., Giliberti A. R., Benetti E., Fallerini C., Furini S., Pinto A. M., Baldassarri M., Fava F., Mari F., Renieri A., Croci S., Tita R., Frullanti E., Altshul D., Huang Q., Hunt K. A., Martin H. C., Mason D., Trembath R. C., Trivedi B., Wright J., Finer S., Griffiths C., van Heel D. A., Jannes C. E., Krieger J. E., Pereira A. C., Marques E., Dalton K., DeBoever C., Jimenez-Morales D., Palomera A. C., Pinsky B., Smith E., Szalma S., Tralau-Stewart C., Wong E., Gorzynski J., de Jong H., Amar D., Delaneau O., Hughes C., Ioannidis A., Raja A., Rubinacci S., Tanigawa Y., Ashley E., Bustamante C., Parikh V., Rivas M., Wheeler M., Busson A., Goffard J. -C., Migeotte I., Peyrassol X., Smits G., Vandernoot I., Wilkin F., Bouysran Y., Pichon B., Tiembe N., Green R., Karlson B., Meigs J., Mercader J., Murphy S., Perez E., Slaugenhaupt S., Smoller J., Weiss S., Woolley A., Feng Y. -C. A., Nivard M. G., Brusco A., Bulik C. M., Franchimont D., Landen M., Louis E., Pedersen N., Rahmouni S., Striano P., Vermeire S., Zara F., Al-Muftah W., Badji R., Ismail S., Al-Sarraj Y., Mbarek H., Arumugam P., Caulfield M., Need A. C., Oscroft T., Rendon A., Scott R. H., Chan G., Kousathanas A., Moutsianas L., Odhams C. A., Pasko D., Rhodes D., Stuckey A., Atkinson E. G., Baya N., Butler-Laporte G., Finucane H., Forgetta V., Kanai M., Karczewski K. J., Koelling N., Martin A. R., Nakanishi T., Palmer D. S., Richards J. B., Spencer C. C. A., Turley P., Walters R. K., Wilson D. J., Armstrong J., O'Connell A. M., Wyllie D. H., Bryant S., Churchhouse C., Di Angelantonio E., Chapman M., Danesh J., Ouwehand W., Roberts D., Watkins N., Butterworth A., Zhao J. H., Biesecker L., Davis L., van Heel D., Kerchberger E., Lee S., Priest J., Richards B., Sankaran V., Chwialkowska K., Francescatto M., Stevens C., Trankiem A., Balaconis K., Liao R., Daly M., Neale B., Bernasconi A., Ceri S., Cordioli M., Niemi M., Zhou W., Nguyen H., Solomonson M., Gopalan S., Hou K., Jansen P., de Leeuw C., Lu Z., Mancuso N., Marouli E., Papadopoulou A., Pasaniuc B., Pathak G., Polimanti R., Posthuma D., Savage J., Uffelmann E., Visscher P., Wendt F. R., Wray N., Yengo L., van Blokland, I, Lanting, P, Ori, A, Vonk, J, Warmerdam, R, Herkert, J, Boulogne, F, Claringbould, A, Lopera-Maya, E, Bartels, M, Hottenga, J, Ganna, A, Karjalainen, J, Hayward, C, Fawns-Ritchie, C, Campbell, A, Porteous, D, Cirulli, E, Barrett, K, Riffle, S, Bolze, A, White, S, Tanudjaja, F, Wang, X, Ramirez, J, Lim, Y, Lu, J, Washington, N, de Geus, E, Deelen, P, Boezen, H, Franke, L, Mierau, J, Dekens, J, Nolte, I, Dijkema, M, Wiersma, H, Jankipersadsing, S, Cho, J, Loos, R, Moscati, A, Chang, Y, Choe, P, Chung, J, Ham, S, Joo, E, Jung, J, Kang, C, Kim, H, Kim, E, Lee, H, Park, S, Park, K, Park, J, Ryu, S, Song, K, Paik, N, Albillos, A, Asselta, R, Bujanda, L, Buti, M, Duga, S, Fernandez, J, Gomez, M, Invernizzi, P, Prati, D, Banales, J, Folseraas, T, Franke, A, Hov, J, Karlsen, T, Valenti, L, Degenhardt, F, Ellighaus, D, Eythorsson, E, Haraldsson, A, Helgason, D, Holm, H, Ingvarsson, R, Jonsdottir, I, Norddahl, G, Palsson, R, Saemundsdottir, J, Stefansson, K, Thorsteinsdottir, U, Gudbjartsson, D, Jonsson, H, Melsted, P, Sulem, P, Sveinbjornsson, G, Alarcon-Riquelme, M, Bernardo, D, Rello, S, Martinez-Bueno, M, Amtrano, S, Bruttini, M, Floriana, V, Giliberti, A, Benetti, E, Fallerini, C, Furini, S, Pinto, A, Baldassarri, M, Fava, F, Mari, F, Renieri, A, Croci, S, Tita, R, Frullanti, E, Altshul, D, Huang, Q, Hunt, K, Martin, H, Mason, D, Trembath, R, Trivedi, B, Wright, J, Finer, S, Griffiths, C, van Heel, D, Jannes, C, Krieger, J, Pereira, A, Marques, E, Dalton, K, Deboever, C, Jimenez-Morales, D, Palomera, A, Pinsky, B, Smith, E, Szalma, S, Tralau-Stewart, C, Wong, E, Gorzynski, J, de Jong, H, Amar, D, Delaneau, O, Hughes, C, Ioannidis, A, Raja, A, Rubinacci, S, Tanigawa, Y, Ashley, E, Bustamante, C, Parikh, V, Rivas, M, Wheeler, M, Busson, A, Goffard, J, Migeotte, I, Peyrassol, X, Smits, G, Vandernoot, I, Wilkin, F, Bouysran, Y, Pichon, B, Tiembe, N, Green, R, Karlson, B, Meigs, J, Mercader, J, Murphy, S, Perez, E, Slaugenhaupt, S, Smoller, J, Weiss, S, Woolley, A, Feng, Y, Nivard, M, Brusco, A, Bulik, C, Franchimont, D, Landen, M, Louis, E, Pedersen, N, Rahmouni, S, Striano, P, Vermeire, S, Zara, F, Al-Muftah, W, Badji, R, Ismail, S, Al-Sarraj, Y, Mbarek, H, Arumugam, P, Caulfield, M, Need, A, Oscroft, T, Rendon, A, Scott, R, Chan, G, Kousathanas, A, Moutsianas, L, Odhams, C, Pasko, D, Rhodes, D, Stuckey, A, Atkinson, E, Baya, N, Butler-Laporte, G, Finucane, H, Forgetta, V, Kanai, M, Karczewski, K, Koelling, N, Martin, A, Nakanishi, T, Palmer, D, Richards, J, Spencer, C, Turley, P, Walters, R, Wilson, D, Armstrong, J, O'Connell, A, Wyllie, D, Bryant, S, Churchhouse, C, Di Angelantonio, E, Chapman, M, Danesh, J, Ouwehand, W, Roberts, D, Watkins, N, Butterworth, A, Zhao, J, Biesecker, L, Davis, L, Kerchberger, E, Lee, S, Priest, J, Richards, B, Sankaran, V, Chwialkowska, K, Francescatto, M, Stevens, C, Trankiem, A, Balaconis, K, Liao, R, Daly, M, Neale, B, Bernasconi, A, Ceri, S, Cordioli, M, Niemi, M, Zhou, W, Nguyen, H, Solomonson, M, Gopalan, S, Hou, K, Jansen, P, de Leeuw, C, Lu, Z, Mancuso, N, Marouli, E, Papadopoulou, A, Pasaniuc, B, Pathak, G, Polimanti, R, Posthuma, D, Savage, J, Uffelmann, E, Visscher, P, Wendt, F, Wray, N, Yengo, L, van Blokland I. V., Lanting P., Ori A. P. S., Vonk J. M., Warmerdam R. C. A., Herkert J. C., Boulogne F., Claringbould A., Lopera-Maya E. A., Bartels M., Hottenga J. -J., Ganna A., Karjalainen J., Hayward C., Fawns-Ritchie C., Campbell A., Porteous D., Cirulli E. T., Barrett K. M. S., Riffle S., Bolze A., White S., Tanudjaja F., Wang X., Ramirez J. M., Lim Y. W., Lu J. T., Washington N. L., de Geus E. J. C., Deelen P., Boezen H. M., Franke L. H., Mierau J. O., Dekens J., Nolte I., Dijkema M. X. L., Wiersma H. H., Jankipersadsing S. A., Cho J. H., Loos R. J. F., Moscati A., Chang Y., Choe P. G., Chung J., Ham S., Joo E. -J., Jung J., Kang C. K., Kim H. -L., Kim H. B., Kim E. S., Lee H. -J., Park S., Park K. -U., Park J. S., Ryu S., Song K. -H., Kim H. -N., Paik N. -J., Albillos A., Asselta R., Bujanda L., Buti M., Duga S., Fernandez J., Gomez M. R., Invernizzi P., Prati D., Banales J. M., Folseraas T., Franke A., Hov J. R., Karlsen T. H., Valenti L., Degenhardt F., Ellighaus D., Eythorsson E. S., Haraldsson A., Helgason D., Holm H., Ingvarsson R. F., Jonsdottir I., Norddahl G. L., Palsson R., Saemundsdottir J., Stefansson K., Thorsteinsdottir U., Gudbjartsson D. F., Jonsson H., Melsted P., Sulem P., Sveinbjornsson G., Alarcon-Riquelme M. E., Bernardo D., Rello S. R., Martinez-Bueno M., Amtrano S., Bruttini M., Floriana V., Giliberti A. R., Benetti E., Fallerini C., Furini S., Pinto A. M., Baldassarri M., Fava F., Mari F., Renieri A., Croci S., Tita R., Frullanti E., Altshul D., Huang Q., Hunt K. A., Martin H. C., Mason D., Trembath R. C., Trivedi B., Wright J., Finer S., Griffiths C., van Heel D. A., Jannes C. E., Krieger J. E., Pereira A. C., Marques E., Dalton K., DeBoever C., Jimenez-Morales D., Palomera A. C., Pinsky B., Smith E., Szalma S., Tralau-Stewart C., Wong E., Gorzynski J., de Jong H., Amar D., Delaneau O., Hughes C., Ioannidis A., Raja A., Rubinacci S., Tanigawa Y., Ashley E., Bustamante C., Parikh V., Rivas M., Wheeler M., Busson A., Goffard J. -C., Migeotte I., Peyrassol X., Smits G., Vandernoot I., Wilkin F., Bouysran Y., Pichon B., Tiembe N., Green R., Karlson B., Meigs J., Mercader J., Murphy S., Perez E., Slaugenhaupt S., Smoller J., Weiss S., Woolley A., Feng Y. -C. A., Nivard M. G., Brusco A., Bulik C. M., Franchimont D., Landen M., Louis E., Pedersen N., Rahmouni S., Striano P., Vermeire S., Zara F., Al-Muftah W., Badji R., Ismail S., Al-Sarraj Y., Mbarek H., Arumugam P., Caulfield M., Need A. C., Oscroft T., Rendon A., Scott R. H., Chan G., Kousathanas A., Moutsianas L., Odhams C. A., Pasko D., Rhodes D., Stuckey A., Atkinson E. G., Baya N., Butler-Laporte G., Finucane H., Forgetta V., Kanai M., Karczewski K. J., Koelling N., Martin A. R., Nakanishi T., Palmer D. S., Richards J. B., Spencer C. C. A., Turley P., Walters R. K., Wilson D. J., Armstrong J., O'Connell A. M., Wyllie D. H., Bryant S., Churchhouse C., Di Angelantonio E., Chapman M., Danesh J., Ouwehand W., Roberts D., Watkins N., Butterworth A., Zhao J. H., Biesecker L., Davis L., van Heel D., Kerchberger E., Lee S., Priest J., Richards B., Sankaran V., Chwialkowska K., Francescatto M., Stevens C., Trankiem A., Balaconis K., Liao R., Daly M., Neale B., Bernasconi A., Ceri S., Cordioli M., Niemi M., Zhou W., Nguyen H., Solomonson M., Gopalan S., Hou K., Jansen P., de Leeuw C., Lu Z., Mancuso N., Marouli E., Papadopoulou A., Pasaniuc B., Pathak G., Polimanti R., Posthuma D., Savage J., Uffelmann E., Visscher P., Wendt F. R., Wray N., and Yengo L.
- Abstract
Epidemiological and genetic studies on COVID-19 are currently hindered by inconsistent and limited testing policies to confirm SARS-CoV-2 infection. Recently, it was shown that it is possible to predict COVID-19 cases using cross-sectional self-reported disease-related symptoms. Here, we demonstrate that this COVID-19 prediction model has reasonable and consistent performance across multiple independent cohorts and that our attempt to improve upon this model did not result in improved predictions. Using the existing COVID- 19 prediction model, we then conducted a GWAS on the predicted phenotype using a total of 1,865 predicted cases and 29,174 controls. While we did not find any common, largeeffect variants that reached genome-wide significance, we do observe suggestive genetic associations at two SNPs (rs11844522, p = 1.9x10-7; rs5798227, p = 2.2x10-7). Explorative analyses furthermore suggest that genetic variants associated with other viral infectious diseases do not overlap with COVID-19 susceptibility and that severity of COVID-19 may have a different genetic architecture compared to COVID-19 susceptibility. This study represents a first effort that uses a symptom-based predicted phenotype as a proxy for COVID-19 in our pursuit of understanding the genetic susceptibility of the disease. We conclude that the inclusion of symptom-based predicted cases could be a useful strategy in a scenario of limited testing, either during the current COVID-19 pandemic or any future viral outbreak.
- Published
- 2021
44. Physicians’ perspectives on the clinical decision-making process in older adults with solid tumors and early signs of cognitive impairment or dementia
- Author
-
Gilissen, J., primary, Decoster, L., additional, Griffiths, A.W., additional, Ritchie, C., additional, and Van den Block, L., additional
- Published
- 2022
- Full Text
- View/download PDF
45. Interprofessional collaborative practice across Australasia: An emergent and effective community of practice
- Author
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Ritchie, C, Gum, L, Brewer, M, Sheehan, D, Burley, M, Saunders-Battersby, S, Evans, S, and Tucker, L
- Published
- 2013
46. 1365P Does cancer care differ for older adults with lung cancer living with and without Alzheimer disease and related dementias (ADRD)?
- Author
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Coombs, L.A., Miller, A., Keeney, T., Gilissen, J., Ritchie, C., and McCarthy, E.P.
- Published
- 2024
- Full Text
- View/download PDF
47. The Role of Organic Polyelectrolytes in High Rate Alternatives to Primary Separation
- Author
-
Becker, N. S. C., Booker, N. A., Davey, A., Gray, S. R., Jago, R., Ritchie, C., Hahn, Hermann H., editor, Hoffmann, Erhard, editor, and Ødegaard, Hallvard, editor
- Published
- 2000
- Full Text
- View/download PDF
48. Abstract No. 375 Percutaneous transesophageal gastrostomy (PTEG): a multiinstitutional review and largest reported case series in the United States
- Author
-
Rotellini-Coltvet, L., primary, Marino, J., additional, Saini, G., additional, Khurana, A., additional, Clinkenbeard, A., additional, Wallace, A., additional, Narayanan, H., additional, Kriegshauser, J., additional, Ritchie, C., additional, and Oklu, R., additional
- Published
- 2022
- Full Text
- View/download PDF
49. Abstract No. 197 Predictors of complete pathologic necrosis in hepatocellular carcinoma treated with yttrium-90 radiation segmentectomy prior to liver transplantation: an explant analysis of 75 tumors
- Author
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Montazeri, S., primary, De la Garza-Ramos, C., additional, Lewis, A., additional, Lewis, J., additional, LeGout, J., additional, Sella, D., additional, Paz-Fumagalli, R., additional, Devcic, Z., additional, Ritchie, C., additional, Frey, G., additional, Vidal, L., additional, McKinney, J., additional, and Toskich, B., additional
- Published
- 2022
- Full Text
- View/download PDF
50. Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors
- Author
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Ritchie, K, Carrière, I, Ritchie, C W, Berr, C, Artero, S, and Ancelin, M-L
- Published
- 2010
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