8 results on '"Rochette V"'
Search Results
2. ATHLETE??S HEART
- Author
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Scharhag, J, primary, Urhausen, A, additional, Schneider, G, additional, Rochette, V, additional, Kramann, B, additional, and Kindermann, W, additional
- Published
- 2002
- Full Text
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3. Athlete's heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging.
- Author
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Scharhag J, Schneider G, Urhausen A, Rochette V, Kramann B, Kindermann W, Scharhag, Jürgen, Schneider, Günther, Urhausen, Axel, Rochette, Veneta, Kramann, Bernhard, and Kindermann, Wilfried
- Abstract
Objectives: Athlete's heart represents a structural and functional adaptation to regular endurance exercise.Background: While left ventricular (LV) hypertrophy of the athlete's heart has been examined in many studies, the extent of right ventricular (RV) hypertrophy is still uncertain because of its complex shape and trabecular structure. To examine RV hypertrophy, we used magnetic resonance imaging (MRI) and hypothesized that athlete's heart is characterized by similar LV and RV hypertrophy.Methods: The LV and RV mass, volume, and function in 21 male endurance athletes (A) (27 +/- 4 years; 70 +/- 8 kg; 178 +/- 7 cm; maximal oxygen uptake [VO(2)max]: 68 +/- 5 ml/min per kg) and 21 pair-matched untrained control subjects (C) (26 +/- 3 years; 71 +/- 9 kg; 178 +/- 6 cm; VO(2)max: 42 +/- 6 ml/min per kg) were analyzed by MRI (Magnetom Vision 1.5T, Siemens, Erlangen, Germany).Results: Left ventricular masses: (A: 200 +/- 20 g; C: 148 +/- 17 g) and RV masses (A: 77 +/- 10 g; C: 56 +/- 8 g) differed significantly between the groups (p < 0.001). The LV and RV end-diastolic volumes (EDV) (LV-EDV 167 +/- 28 ml [A]; 125 +/- 16 ml [C]; RV-EDV 160 +/- 26 ml [A]; 128 +/- 10 ml [C]), and stroke volumes (SV) (LV-SV: 99 +/- 18 ml [A], 74 +/- 11 ml [C]; RV-SV: 102 +/- 18 ml [A], 79 +/- 8 ml [C]) were significantly different between the athletes and control subjects (p < 0.001), whereas ejection fractions (EF) (LV-EF: 59 +/- 3% [A]; 59 +/- 6% [C]; RV-EF: 63 +/- 3% [A], 62 +/- 3% [C]) and LV-to-RV ratios were similar for both groups (LV-to-RV mass: 2.6 +/- 0.2 [A], 2.6 +/- 0.3 [C]; LV-to-RV EDV: 1.05 +/- 0.14 [A], 0.99 +/- 0.14 [C]; LV-to-RV SV: 0.98 +/- 0.17 [A], 0.95 +/- 0.17 [C]; LV-to-RV EF: 0.93 +/- 0.07 [A], 0.96 +/- 0.10 [C]).Conclusions: Regular and extensive endurance training results in similar changes in LV and RV mass, volume, and function in endurance athletes. This leads to the conclusion that the athlete's heart is a balanced enlarged heart. [ABSTRACT FROM AUTHOR]- Published
- 2002
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4. Microbial contamination and isolator gloves: if it all came down to the size of a hole?
- Author
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Filaire E, Rochette V, Pierre E, Arethuse F, Champagnat P, Coppens P, Gohier E, Mounier C, Toussaint A, Triquet J, and Poinsot C
- Abstract
Isolators play a critical role in protecting both the product and the environment, as well as the personnel involved in pharmaceutical manufacturing, analytical procedures and sterility testing. Gloves attached to the windows and doors of the isolator are designed to facilitate intervention, testing and safety. However, due to their inherent characteristics and vulnerability to puncture or loss of integrity, they are recognised as a significant potential source of contamination. In addition to the possible pathways of contamination transfer, the size of glove holes plays a critical role in determining the risk of contamination. In this study, chlorosulphonated polyethylene (CSM) gloves were exposed to an aerosol containing Bacillus subtilis or Staphylococcus aureus. This assessment aimed to ascertain the integrity of the gloves' seal. It was postulated that, below a certain aperture size, gloves used in isolator systems could establish an effective seal, even if the external surface of the gloves exhibited modifications. Calibrated holes of different diameters (0.3, 0.5, 1, 1.5 mm) were created using a femtosecond laser drilling technology. The holes were located on the tip of the middle finger. Based on the context of our study, passage of micro-organisms through glove holes of a certain size does occur. Under the experimental conditions chosen, the cut-off for passage was determined to be a 0.5 mm hole, regardless of the micro-organism evaluated. Although this study has some limitations, including the lack of a panel of micro-organisms evaluated and the investigation of a single glove type called CSM, the high level of "worst case" challenge conditions provides compelling data to support our results. It would now be interesting to carry out studies at different production sites to assess their risk of contamination and relate this to their glove failure., (Copyright © 2024, Parenteral Drug Association.)
- Published
- 2024
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5. Prophylactic Antibiotics Delivered Via the Respiratory Tract to Reduce Ventilator-Associated Pneumonia: A Systematic Review, Network Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials.
- Author
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Li J, Lyu S, Luo J, Liu P, Albuainain FA, Alamoudi OA, Rochette V, and Ehrmann S
- Subjects
- Humans, Administration, Inhalation, Network Meta-Analysis, Randomized Controlled Trials as Topic, Respiration, Artificial adverse effects, Anti-Bacterial Agents administration & dosage, Antibiotic Prophylaxis methods, Pneumonia, Ventilator-Associated epidemiology, Pneumonia, Ventilator-Associated prevention & control
- Abstract
Objectives: To assess the effects of antibiotics delivered via the respiratory tract in preventing ventilator-associated pneumonia (VAP)., Data Sources: We searched PubMed, Scopus, the Cochrane Library, and ClinicalTrials.gov for studies published in English up to October 25, 2023., Study Selection: Adult patients with mechanical ventilation of over 48 h and receiving inhaled or instilled antibiotics (with control group) to prevent VAP were included., Data Extraction: Two independent groups screened studies, extracted the data, and assessed the risk of bias. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to assess the certainty/quality of the evidence. Results of a random-effects model were reported for overall and predefined subgroup meta-analyses. The analysis was primarily conducted on randomized controlled trials, and observational studies were used for sensitivity analyses., Data Synthesis: Seven RCTs with 1445 patients were included, of which six involving 1283 patients used nebulizers to deliver antibiotics. No obvious risk of bias was found among the included RCTs for the primary outcome. Compared with control group, prophylactic antibiotics delivery via the respiratory tract significantly reduced the risk of VAP (risk ratio [RR], 0.69 [95% CI, 0.53-0.89]), particularly in subgroups where aminoglycosides (RR, 0.67 [0.47-0.97]) or nebulization (RR, 0.64 [0.49-0.83]) were used as opposed to other antibiotics (ceftazidime and colistin) or intratracheal instillation. No significant differences were observed in mortality, mechanical ventilation duration, ICU and hospital length of stay, duration of systemic antibiotics, need for tracheostomy, and adverse events between the two groups. Results were confirmed in sensitivity analyses., Conclusions: In adult patients with mechanical ventilation for over 48 h, prophylactic antibiotics delivered via the respiratory tract reduced the risk of VAP, particularly for those treated with nebulized aminoglycosides., Competing Interests: Dr. Li’s institution received funding from the Rice Foundation, the American Association for Respiratory Care, Aerogen Ltd, and Fisher & Paykel Healthcare Ltd; she received speaker fees from Fisher & Paykel Healthcare Ltd, the American Association for Respiratory Care, Aerogen Ltd, Heyer Ltd, and Vincent Ltd. Dr. Ehrmann’s institution received funding from Aerogen Ltd, Fisher & Paykel Healthcare and Open AI; he received consultancies from Aerogen Ltd, travel reimbursements from Aerogen Ltd, and Fisher & Paykel Healthcare Ltd. The remaining authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2024 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.)
- Published
- 2024
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6. Focus on Bioburden Culture Media and Medical Devices.
- Author
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Filaire E, Rochette V, Jarousse E, and Poinsot C
- Subjects
- Humans, Bacteria, Patient Safety, Culture Media, Sterilization methods, Microbiological Techniques
- Abstract
Medical devices are a vital part of the global health care system that can have a far-reaching impact on patient treatment. Therefore, they must be sterile to ensure patient safety. The prevalent microorganism's type on a medical device, also known as "bioburden", is a useful indicator of a potential contamination source. Indeed, bioburden is a potential risk to the patient not only because the sterilization process might not be completely effective, but also post-processing because of the possible presence of residual materials. Although bioburden may be confidently killed by destructive sterilization processes, its proliferation before sterilization should be avoided. For the bioburden determination, the culture media and incubation conditions must be carefully selected. The culture medium is of fundamental importance for most microbiological tests: to obtain pure cultures, to grow and count microbial cells, and to cultivate and select microorganisms. A culture medium is essentially composed of basic elements (water, nutrients) to which must be added different growth factors that will be specific to each bacterium and necessary for their growth. Without high-quality media, the possibility of achieving accurate, reproducible, and repeatable microbiological test results is reduced. In ISO 11737-1:2018 "Sterilization of Health Care Products-Microbiological Methods-Part 1: Determination of a Population of Microorganisms on Products", methods for the determination and microbial characterization of bioburden are proposed. However, few guidelines are given as to culture media other than examples and incubation times. Several studies show that other culture media can also be effective, such as Plate Count Agar (PCA). The purpose of this review was to focus on parameters that can have an impact on the bioburden evaluation, specifically the culture medium type for the microorganisms' detection on medical devices. Experimentations conducted in our laboratories showed that PCA appeared to be a medium of primary importance for the detection of bioburden on medical devices; this medium also respects the 3Rs rule., (© PDA, Inc. 2023.)
- Published
- 2023
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7. Anti-Biofilm Activity of a Low Weight Proteinaceous Molecule from the Marine Bacterium Pseudoalteromonas sp. IIIA004 against Marine Bacteria and Human Pathogen Biofilms.
- Author
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Doghri I, Portier E, Desriac F, Zhao JM, Bazire A, Dufour A, Rochette V, Sablé S, and Lanneluc I
- Abstract
Pseudoalteromonas bacteria are known as potential bioactive metabolite producers. Because of the need to obtain natural molecules inhibiting the bacterial biofilms, we investigated the biofilm inhibitory activity of the marine bacterium Pseudoalteromonas sp. IIIA004 against the pioneer surface colonizer Roseovarius sp. VA014. The anti-biofilm activity from the culture supernatant of Pseudoalteromonas sp. IIIA004 (SN
IIIA004 ) was characterized in microtiter plates (static conditions/polystyrene surface) and in flow cell chambers (dynamic conditions/glass surface). The Pseudoalteromonas exoproducts exhibited an inhibition of Roseovarius sp. VA014 biofilm formation as well as a strong biofilm dispersion, without affecting the bacterial growth. Microbial adhesion to solvent assays showed that SNIIIA004 did not change the broad hydrophilic and acid character of the Roseovarius strain surface. Bioassay-guided purification using solid-phase extraction and C18 reverse-phase-high-performance liquid chromatography (RP-HPLC) was performed from SNIIIA004 to isolate the proteinaceous active compound against the biofilm formation. This new anti-biofilm low weight molecule (< 3kDa), named P004 , presented a wide spectrum of action on various bacterial biofilms, with 71% of sensitive strains including marine bacteria and human pathogens. Pseudoalteromonas sp. IIIA004 is a promising source of natural anti-biofilm compounds that combine several activities.- Published
- 2020
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8. [Left ventricular mass in endurance-athletes with athlete's heart and untrained subjects--comparison between different echocardiographic methods and MRI].
- Author
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Scharhag J, Urhausen A, Schneider G, Rochette V, Kramann B, and Kindermann W
- Subjects
- Adult, Heart Ventricles pathology, Heart Ventricles physiopathology, Humans, Hypertrophy, Left Ventricular physiopathology, Male, Mathematical Computing, Reference Values, Reproducibility of Results, Cardiac Volume physiology, Echocardiography, Hypertrophy, Left Ventricular diagnosis, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Physical Endurance physiology, Sports physiology
- Abstract
Unlabelled: The echocardiographic determination of left ventricular mass (LVM) and volume is of importance for the interpretation of cardiac adaptations and risk-stratification. In pathologically hypertrophied hearts, conventional one- and two-dimensional echocardiographic methods tend to overestimate LVM. For the athlete's heart, a comparison between different echocardiographic methods and magnetic resonance imaging (MRI) has not been performed so far. 23 healthy male endurance-athletes (28+/-4 yr) with athlete's heart (A) and 26 healthy untrained males (U; 26+/-4 yr) were examined by MRI and the following echocardiographic methods: ASE-Cube (ASE), Devereux (DEV), Troy (TRO), Teichholz (TEI), Reichek (REI) and Dickhuth (DIC). Indexed LVM were: MRI: 107+/-6 g/m(2) (A), 79+/-7 g/m(2) (U); ASE: 170+/-20 g/m(2) (A), 119+/-14 g/m(2) (U); DEV: 134+/-16 g/m(2) (A), 95+/-11 g/m(2) (U); TRO: 134+/-16 g/m(2) (A), 92+/-12 g/m(2) (U); TEI: 115+/-10 g/m(2) (A), 91+/-8 g/m(2) (U); REI: 114+/-14 g/m(2) (A), 89+/-11 g/m(2) (U); DIC: 110+/-14 g/m(2) (A); 80+/-9 g/m(2) (U). In A and U, LVM is significantly overestimated by ASE, DEV, TRO, TEI, and REI compared to MRI (p<0.05), but not by DIC. Although coefficients of correlation were similar, only DIC revealed acceptable limits of agreement (ASE: +20 to +172 g; DEV: -13 to +93 g; TRO: -18 to +92 g; TEI: -17 to +53 g; REI: -25 to +57 g; DIC: -37 to +45 g). Depending on the used method, LVM upper limits range between 93 (MRT) and 146 g/m(2) (ASE) in U, and 119 (MRT) and 209 g/m(2) (ASE) in A., Conclusion: Compared to MRI, DIC is the most accurate conventional echocardiographic method to determine LVM in U and A. For a correct interpretation of LVM, differences of the echocardiographic methods have to be considered.
- Published
- 2003
- Full Text
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